Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DAGKc	SPHK1 DGKQ	1.59e-03	14	80	2	SM00046
Domain	Diacylglycerol_kinase_cat_dom	SPHK1 DGKQ	1.83e-03	15	80	2	IPR001206
Domain	DAGK_cat	SPHK1 DGKQ	1.83e-03	15	80	2	PF00781
Domain	DAGK	SPHK1 DGKQ	1.83e-03	15	80	2	PS50146
Domain	Laminin_N	NTNG2 LAMA5	2.09e-03	16	80	2	IPR008211
Domain	LAMININ_NTER	NTNG2 LAMA5	2.09e-03	16	80	2	PS51117
Domain	Laminin_N	NTNG2 LAMA5	2.09e-03	16	80	2	PF00055
Domain	LamNT	NTNG2 LAMA5	2.09e-03	16	80	2	SM00136
Domain	NAD/diacylglycerol_kinase	SPHK1 DGKQ	2.36e-03	17	80	2	IPR016064
Domain	zf-DHHC	ZDHHC18 ZDHHC9	4.32e-03	23	80	2	PF01529
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP3 PITPNM2 EPPK1 SETD1B LRRC24 SH3TC1 SPHK1 NBEAL2 NISCH KBTBD11 LAMA5 DGKQ TWNK MMP14 ARHGAP33 TRAK1	1.38e-08	1105	87	16	35748872
Pubmed	The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein.	C1QBP MMP14	6.19e-06	2	87	2	12220632
Pubmed	The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR.	C1QBP MMP14	6.19e-06	2	87	2	11773076
Pubmed	Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin-malin complex.	PPP1R3D EPM2A	6.19e-06	2	87	2	23624058
Pubmed	Ppp1r3d deficiency preferentially inhibits neuronal and cardiac Lafora body formation in a mouse model of the fatal epilepsy Lafora disease.	PPP1R3D EPM2A	1.85e-05	3	87	2	32892347
Pubmed	Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma.	EPO EPX	1.85e-05	3	87	2	27587397
Pubmed	Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration.	LAMA5 MMP14	3.70e-05	4	87	2	15967115
Pubmed	A novel EPM2A mutation yields a slow progression form of Lafora disease.	PPP1R3D EPM2A	3.70e-05	4	87	2	30041081
Pubmed	SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis.	TACO1 C1QBP ECHS1 SPG21	6.05e-05	84	87	4	36575184
Pubmed	S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary.	ZDHHC18 ZDHHC9	6.16e-05	5	87	2	27481942
Pubmed	Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2.	EPO EPX	9.22e-05	6	87	2	10770291
Pubmed	Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells.	AMH GLI2	9.22e-05	6	87	2	21209421
Pubmed	Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation.	ZDHHC18 ZDHHC9	9.22e-05	6	87	2	38182928
Pubmed	TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice.	SIRPA EPX	1.29e-04	7	87	2	38689088
Pubmed	Mouse minipuberty coincides with gonocyte transformation into spermatogonial stem cells: a model for human minipuberty.	AMH MMP14	1.72e-04	8	87	2	28531375
Pubmed	Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN).	EPO ZAN	1.72e-04	8	87	2	9126492
Pubmed	Characterization of a 190-kilobase pair domain of human type I hair keratin genes.	KRT38 KRT37	2.20e-04	9	87	2	9756910
Pubmed	Human hair keratins.	KRT38 KRT37	2.20e-04	9	87	2	7686952
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	EPO BMP1 CD1D IL15RA SSC4D GDF7 SPHK1 LY9 EPX	2.22e-04	824	87	9	20237496
Pubmed	Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development.	SPHK1 NBEAL2	2.75e-04	10	87	2	25908104
Pubmed	The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.	KRT38 KRT37	2.75e-04	10	87	2	10391933
Pubmed	Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung.	GLI2 LAMA5	3.35e-04	11	87	2	12051813
Pubmed	TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog.	EPO ZAN	3.35e-04	11	87	2	10575226
Pubmed	The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.	KRT38 KRT37	4.02e-04	12	87	2	15617563
Pubmed	Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.	EPO ZAN	4.74e-04	13	87	2	11239002
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	LAMA5 MMP14	5.52e-04	14	87	2	20858856
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	GLI2 LAMA5	5.52e-04	14	87	2	19783738
Pubmed	Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.	EPO ZAN	5.52e-04	14	87	2	9799793
Pubmed	Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor.	AMH GLI2	6.36e-04	15	87	2	25609427
Pubmed	Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system.	ZDHHC18 ZDHHC9	7.26e-04	16	87	2	23034182
Pubmed	Chromosomal mapping of Adam9, Adam15 and Adam21.	ADRB3 LY9	9.22e-04	18	87	2	10842103
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	DGKQ CCDC120 OLFM2 KRT38 KRT37 ARHGAP33 SPG21	1.04e-03	630	87	7	36949045
Pubmed	Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.	ZDHHC18 ZDHHC9	1.14e-03	20	87	2	16647879
Pubmed	Temporomandibular joint formation requires two distinct hedgehog-dependent steps.	GDF7 GLI2	1.26e-03	21	87	2	19815519
Pubmed	Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.	EPO GP1BB	1.38e-03	22	87	2	22387002
Pubmed	Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice.	AMH GLI2	1.38e-03	22	87	2	25224227
Pubmed	GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.	AMH GLI2	1.65e-03	24	87	2	32497091
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SETD1B EXOC7 TRAK1	2.29e-03	104	87	3	10470851
Pubmed	Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.	GDF7 GLI2	2.40e-03	29	87	2	21209331
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	EPPK1 CYP2F1 SPHK1 FER1L4 CCDC120	1.66e-05	162	87	5	aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TACO1 CD1D THEM4 EPX CAPN15	1.76e-05	164	87	5	b175258fb0885afd84d4a414c0ae441f880e8469
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TACO1 CD1D THEM4 EPX CAPN15	1.76e-05	164	87	5	875d922eec7e3df0998ddf0c8c4dee2dcd5b23ca
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TACO1 CD1D THEM4 EPX CAPN15	1.76e-05	164	87	5	8bcfc93220d7c99dddb32b7fa7fb9aec2a1c63fa
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3D HIVEP3 NTNG2 LY9 MMP14	2.21e-05	172	87	5	3f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3D NTNG2 SIRPA LY9 MMP14	2.53e-05	177	87	5	14fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	EPO SH3TC1 SPHK1 KBTBD11 SIRPA	2.67e-05	179	87	5	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	EPO SH3TC1 SPHK1 KBTBD11 SIRPA	2.67e-05	179	87	5	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ZDHHC18 NTNG2 THSD7A R3HDM4 NBEAL2	3.05e-05	184	87	5	7ecdf2645e9378cf2f5ce4557f2cf100e6f184ba
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP3 PITPNM2 ADRB3 LAMA5 CCDC120	3.13e-05	185	87	5	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	HIVEP3 SH3TC1 NIT1 UBASH3A DDB2	3.30e-05	187	87	5	816d37a70f7ec382a268fe828b3dfe737a36a4bf
Disease	Encephalopathy, Subacute Necrotizing, Infantile	TACO1 ECHS1	2.58e-04	9	80	2	C0751267
Disease	Encephalopathy, Subacute Necrotizing, Juvenile	TACO1 ECHS1	2.58e-04	9	80	2	C0751268
Disease	Leigh Disease	TACO1 NDUFAF6 ECHS1	2.86e-04	47	80	3	C0023264
Disease	ischemia (implicated_via_orthology)	SCNN1D MMP14	9.61e-04	17	80	2	DOID:326 (implicated_via_orthology)
Disease	schizophrenia, inflammatory bowel disease	EPO EPX	1.08e-03	18	80	2	EFO_0003767, MONDO_0005090
Disease	polymyositis	THSD7A DGKQ	1.34e-03	20	80	2	EFO_0003063
Disease	mean platelet volume	PITPNM2 EPO EPM2A SETD1B ZAN PCDHGC4 SIRPA EPX GP1BB	1.75e-03	1020	80	9	EFO_0004584
Disease	congestive heart failure (is_implicated_in)	EPO NISCH	2.44e-03	27	80	2	DOID:6000 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TAICALPGPLALRPA	ZNF385C	371	Q66K41
CALPGRPGLTLLCRP	EPM2A	196	B3EWF7
LVLLLCAPLPPGARA	EPHA1	11	P21709
LLQPAPRLCTRPFGL	C1QBP	31	Q07021
PCLALPVGLALGPTR	ARID3C	296	A6NKF2
LGPCGLRLVGARPLL	HSD3B7	276	Q9H2F3
RCRQGATRLPLPPLL	ASB16	426	Q96NS5
PCPRLLPGSPTVRHL	CD300LD-AS1	206	Q96MU5
SLVLPPACVRLLPGG	DGKQ	241	P52824
GVPACGRRPARLLPL	ADRB3	271	P13945
PLRGRFCGSKLPEPI	BMP1	391	P13497
RPPRCLLLPLLTLGT	MMP14	6	P50281
GTPGGRRLLPLPSCL	R3HDM4	16	Q96D70
VPPPLLLLLCSGLAG	OLFM2	6	O95897
GLGNLPRPFQLCLRP	CYP2F1	476	P24903
HLPSVCGERLRGPLP	NPIPB12	656	F8W0I5
CGGPRRLSLPRIPPE	CAPN15	166	O75808
REPGLRPRILLCAPP	ATOH8	146	Q96SQ7
PGPRALGCLVLLEPL	DCHS1	2546	Q96JQ0
LLLRPPATRGITCPP	IL15RA	21	Q13261
RVGSTPLGRPSLCLP	KRT37	56	O76014
RVGSTPLGRPSLCLP	KRT38	56	O76015
SGRLSLPPNVCPVLR	FER1L4	921	A9Z1Z3
RGAPRLPPVCGDFLL	CCDC120	431	Q96HB5
LRCVAPPALRGRLLP	GP1BB	116	P13224
VLLSCVRGPLRPPVR	ECHS1	6	P30084
LLLGLFRPPPALCAR	PCSK1N	21	Q9UHG2
EPLLPGARVGPLLAC	EPX	621	P11678
GPLRLGIPGLCCRRP	NDUFAF6	11	Q330K2
VPPAGPGLCLLRFLA	PLK5	246	Q496M5
CGALRLRVVPLGIPP	LRRC24	36	Q50LG9
HLPSVCGERLRGPLP	NPIPB5	861	A8MRT5
LGVIPCVGRPTRPCR	GOLGA2P5	76	Q9HBQ8
GPLPPCADRRGLRLQ	GLI2	996	P10070
APLLARLLALCPGGP	AMH	401	P03971
RRPLEVLLGCPVPLG	NLRP5	646	P59047
LTLPRGTTCLPPALL	TWNK	281	Q96RR1
LCVRGPRGPAPLLLV	LAMA5	11	O15230
LRPRARPGSLCPQAL	PCDHGC4	566	Q9Y5F7
LRAPSTCPLLQGGPL	PAQR6	321	Q6TCH4
SALGRLAIRLVPCPP	PITPNM2	466	Q9BZ72
GLAGPQILPPCRSIV	DDB2	56	Q92466
HLPSVCGERLRGPLP	NPIPB4	866	C9JG80
LIPLEGLLPCTPRGG	EXOC7	296	Q9UPT5
LLQLLPPGLLPGCAI	SRD5A3	31	Q9H8P0
PAGRCLLPRPKSLAG	ARHGAP33	521	O14559
RGPSPGPGRLLLVCH	CD1D	211	P15813
LGLPVLGAPPRLICD	EPO	21	P01588
RRCPGLLKPHPSRGL	MAP3K12	466	Q12852
LGEPVTLPLALPACR	LY9	261	Q9HBG7
LLPLSGRRIPPLNLG	MAN1A2	6	O60476
LLPLVTLCDGNPRRP	SCNN1D	291	P51172
TRPPHRFLSLLCPGL	NIT1	6	Q86X76
PRRLLAPCLPARAAG	PRR18	171	Q8N4B5
PGAAPRPATLLGCLL	NTNG2	506	Q96CW9
CPLLTGGRPLPTLEV	SFSWAP	721	Q12872
LERVPRGRPCLVPGK	RMI2	86	Q96E14
MGPGPRLLLPLVLCV	PPIC	1	P45877
AGPRRGVLQLLPLPL	THSD7A	16	Q9UPZ6
CLLARGPGVRAAPPR	TACO1	16	Q9BSH4
LSRPSCLPLPELGLV	TAF2	981	Q6P1X5
LVRPGSLPLLPDRVC	NBEAL2	1166	Q6ZNJ1
LPLGRLHALCPGCPL	PRORY	121	Q9H606
PPRAFCLLLRAVAGP	GDF7	226	Q7Z4P5
CLLLRAVAGPVPSPL	GDF7	231	Q7Z4P5
TGGLVCPARRLRLPL	EPPK1	401	P58107
PAPGRLGPLLCLLLA	SIRPA	6	P78324
LNVRRVNLPPLPLCG	SH3TC1	1311	Q8TE82
GPLLLPVCPLPTGRR	SETD1B	1441	Q9UPS6
DAGPRSIRCPLIFLP	SPG21	36	Q9NZD8
LGGPSRPRPLMLCGL	SPATA25	116	Q9BR10
LRLPGGPTGLQPFRC	KBTBD11	541	O94819
CAARLLRQRLPGPPD	PDXP	91	Q96GD0
TLGPAPALCVRTPLR	LINC00612	31	Q8N6U2
PRGLVPEGLPLRCPT	TRAK1	886	Q9UPV9
VLCGPLPPSVLDRRG	ZDHHC9	286	Q9Y397
CRQLGCGLALPVPRP	SSC4D	96	Q8WTU2
ALCSGLPLRPLPENR	UROC1	6	Q96N76
TLGALCLPPVGRRLP	THEM4	11	Q5T1C6
PGCCRGPLRPKTLLL	NISCH	1361	Q9Y2I1
HLTRAPCPLIPIGGI	HIVEP3	2186	Q5T1R4
APSGCDPRLRPIILR	PPP1R3D	56	O95685
LLSLVRGLLPCLPPG	SEMA5B	36	Q9P283
GPRGVLPRPCRVLVL	SPHK1	6	Q9NYA1
LPRPCRVLVLLNPRG	SPHK1	11	Q9NYA1
AGPRKLLVPGLPCLV	WWC2-AS2	41	Q96NR7
AVLCGPLPPSLIDRR	ZDHHC18	341	Q9NUE0
TLDSCTRPLLGLPPR	UBASH3A	591	P57075
TLPSILCQPGRPRGL	ZAN	2611	Q9Y493
RLLRVGGACPTPLPV	nan	21	Q6ZSA8