Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone binding

PRMT6 PYGO2 RCC1 CHD7 TSPYL4 L3MBTL3

5.64e-05265516GO:0042393
GeneOntologyMolecularFunctiontransmembrane transporter binding

AKAP6 FGF12 NOS1 ITPR1 KCNH5

7.63e-05172515GO:0044325
GeneOntologyMolecularFunctionchromatin binding

PRMT6 PYGO2 TOX APEX1 RCC1 POU4F1 CHD7 TSPYL4 L3MBTL3

9.36e-05739519GO:0003682
Pubmed

PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.

PRMT6 RCC1

2.19e-06252233539787
Pubmed

Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction.

EPHB2 RGS3

3.28e-05652211301003
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

BYSL APEX1 RCC1 CHD7 IK L3MBTL3 SF1 SRSF12

8.04e-0595452836373674
Pubmed

Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons.

EPHB2 POU4F1

9.79e-051052211493560
Pubmed

Minor spliceosome components are predominantly localized in the nucleus.

RNPC3 SF1

9.79e-051052218559850
Pubmed

Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism.

EPHB2 RGS3

1.20e-041152219515977
Pubmed

Ipsilateral and Contralateral Retinal Ganglion Cells Express Distinct Genes during Decussation at the Optic Chiasm.

POU4F1 FGF12

3.30e-041852227957530
Pubmed

Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina.

POU4F1 NOS1

4.09e-042052216026391
Pubmed

Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.

POU4F1 SF1

4.52e-042152223300469
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

TOX LTN1 TSPYL4

4.74e-041015239872452
Pubmed

m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina.

APEX1 POU4F1

4.97e-042252236459087
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

PRMT6 RCC1 SF1 SRSF12

5.22e-0424852427926873
Pubmed

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.

EPHB2 COL4A1

5.44e-042352226027930
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

RNPC3 SRPK1 IK SRSF12

5.46e-0425152431076518
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

RNPC3 L3MBTL3 TMEM132B

5.61e-0410752311347906
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

ARMCX4 MYO18B

5.93e-042452232212159
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

RNPC3 LTN1 BYSL SRPK1 IK SRSF12

6.64e-0471352629802200
Pubmed

Spatiotemporal structure of cell fate decisions in murine neural crest.

COL4A1 POU4F1

6.96e-042652231171666
Pubmed

Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.

NOS1 SF1

6.96e-042652228684471
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

EPHB2 RAB3GAP1 PYGO2 TATDN2 SRPK1 RCC1 ENSA

7.78e-04102152726760575
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

STK36 RAB3GAP1 RNPC3 LTN1 ZKSCAN5

8.42e-0449352515368895
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

APEX1 CHD7 IK SF1

8.55e-0428352430585729
Pubmed

Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.

APEX1 ITPR1

8.67e-042952232123907
Pubmed

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.

TOX CHD7

8.67e-042952223396134
Pubmed

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.

COL4A1 FGF12

9.29e-043052220083228
Pubmed

miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.

PCLO FGF12

9.92e-043152237816598
Pubmed

Interaction proteomics of the HMGA chromatin architectural factors.

APEX1 RCC1

1.06e-033252218850631
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RNPC3 APEX1 RCC1 CHD7 IK ZC3H6 SF1

1.09e-03108252738697112
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

PRMT6 KDM5C

1.12e-033352226864203
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

AVEN TATDN2 CHD7 KCNH5

1.24e-0331352420800603
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PCLO RGS3

1.96e-0336332823
GeneFamilyPDZ domain containing

PCLO NOS1 RGS3

2.64e-031523331220
GeneFamilyCollagens

COL4A1 COL26A1

3.18e-0346332490
CoexpressionWELCSH_BRCA1_TARGETS_DN

KDM5C BYSL APEX1 SRPK1 RCC1

8.90e-06141525M2428
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#3_top-relative-expression-ranked_1000

PRMT6 STK36 COL26A1 BYSL NUBP1 CHD7 SF1

3.48e-05376527gudmap_developingKidney_e11.5_metaneph mesench_1000_k3
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOX FGF12 TMEM132B GPR179 ITPR1

2.75e-06189525fcc3713e8200d51074f709f3360fb36efb0a639f
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 BYSL NOS1 SRSF12

2.29e-051425245690eee2ce1ecd02e34eac4193578bd13c4228b9
ToppCellVE-Treg-naive_CD4|VE / Condition, Cell_class and T cell subcluster

PNMA5 RNPC3 SRPK1 ARMCX4

3.31e-051565246501baf73616e702946de9fb13d267e30a68888b
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PYGO2 TOX ZKSCAN5 SRSF12

3.65e-0516052455f599df6e3b7a5a505df4b094c834281311d94a
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PYGO2 TOX ZKSCAN5 SRSF12

3.65e-05160524296e53e1e0786346d38db2d4188b9a1c0430627b
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGF12 TMEM132B GPR179 ITPR1

5.77e-051805248bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCellCV-Healthy-7|CV / Virus stimulation, Condition and Cluster

RNPC3 ARMCX4 TSPYL4 NLRP6

6.29e-051845240e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCellCV-Healthy-7|Healthy / Virus stimulation, Condition and Cluster

RNPC3 ARMCX4 TSPYL4 NLRP6

6.42e-051855241979d189c204f4c2893e3170a514ee7d5523406c
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AKAP6 FGF12 MYO18B RGS3

6.83e-051885246d249fe92d51a19da19ec14bb2262d394255d577
ToppCellCOVID-19-Heart|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 COL4A1 FGF12 MYO18B

7.12e-05190524918ad5037881212008f9f69d5df5da91fd01422c
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

AKAP6 FGF12 MYO18B RGS3

7.27e-051915245d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 PCLO CHD7 NOS1

7.41e-05192524fe9297cb65234d9f511bab1a5dbf2679d5a4cd15
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOX FGF12 GPR179 ITPR1

7.56e-051935246995ee29bf403a71247de92a37dfd851be5acf2e
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOX FGF12 GPR179 ITPR1

7.56e-051935247fcfb0f76789fa8d8caa18304cb43c8fd899a81b
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AKAP6 FGF12 MYO18B RGS3

7.72e-0519452489812fb164065041357bb37a3c2d87028ec3de4e
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

AKAP6 FGF12 MYO18B RGS3

7.72e-05194524c3535f7cc0076653c72db582047cff053c322397
ToppCellprimary_visual_cortex-Neuronal|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCLO FGF12 TSPYL4 ENSA

8.03e-051965248efc2b3a95f57c31be203ac781b2098d4909297f
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCLO FGF12 TMEM132B ITPR1

8.35e-05198524c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCLO FGF12 TMEM132B ITPR1

8.35e-051985244ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 PCLO CHD7 NOS1

8.51e-0519952447466253069d4b1b8f13ce3210f434e60753b38a
Diseasemelanoma

APEX1 TSPYL4 TMEM132B SF1

8.28e-04248504C0025202
DiseaseDevelopmental delay (disorder)

COL4A1 KDM5C

1.80e-0337502C0424605
Diseasediabetic nephropathy

COL4A1 PDILT ITPR1

2.12e-03150503EFO_0000401

Protein segments in the cluster

PeptideGeneStartEntry
MQPEGAEKGKSFKQR

AQP9

1

O43315
QKPGGSDFLMKRLQK

ENSA

46

O43768
PGGISGNKLKLMLQK

ECRG4

26

Q9H1Z8
AKRQEKKGMEPLQGH

CREBRF

271

Q8IUR6
NQKGQEIKPGSMGKG

ACSM4

381

P0C7M7
MPKRGKKGAVAEDGD

APEX1

1

P27695
RVPVVNKRNGKKMGG

CHD7

2646

Q9P2D1
KVRGNVNTMPKEGAG

ARMCX4

491

Q5H9R4
MKGQKGDQGEKGQIG

COL4A1

946

P02462
GQLGLGENVMERKKP

RCC1

46

P18754
ESGKKGGPKEMANLR

RAB3GAP1

601

Q15042
MPGGGDTENGKKLKI

RGS3

286

P49796
KNGFKVGMKLEGVDP

L3MBTL3

261

Q96JM7
MGGKNKQRTKGNLRP

LTN1

1

O94822
GPKKNGMIKQFLRDV

NUBP1

146

P53384
REKMNKPELFNGGEK

POU4F1

341

Q01851
PRGGESQKDKEKMPG

GPR179

1611

Q6PRD1
PISKMAKGEENKGNN

ITPR1

906

Q14643
DGTVEMRGKDKKQQP

IHO1

431

Q8IYA8
KVNSPIRMKNGNGKG

KCNH5

796

Q8NCM2
GMGKKKTDPGRGREI

EPHB2

1021

P29323
PRIGKMGQNGQEPVK

PCLO

4976

Q9Y6V0
RKKQVGPEMGGEQLG

MIGA2

71

Q7L4E1
NKPKDQMGGHELRKN

PLEKHM3

471

Q6ZWE6
RGVKGGAPAKAEMKD

NOS1

221

P29475
QGKAGLQMKSPEKKR

PYGO2

31

Q9BRQ0
PKRTDDGKGLGMQLK

AVEN

216

Q9NQS1
MSQPKKRKLESGGGG

PRMT6

1

Q96LA8
MPKFKAARGVGGQEK

BYSL

1

Q13895
ANLKMKRGGAQPDGV

COL26A1

406

Q96A83
QGPAGIGKTMAAKKI

NLRP6

201

P59044
ELGKAVEIMGKGKNG

PDILT

81

Q8N807
GLNKEGQIMKGNRVK

FGF12

176

P61328
IQGILGKSMPKRKGE

TATDN2

191

Q93075
QSPMEGKNKLLKSGG

TMEM132B

851

Q14DG7
LSQKVRPGDNEMKKG

TDRD15

1486

B5MCY1
EMEKESGPGQKRPNK

SRPK1

291

Q96SB4
AQGDRKTPGQMKSKE

SRSF12

86

Q8WXF0
MKPQNILLAKGGGIK

STK36

126

Q9NRP7
FKNDLKGNGGKRQMV

AKAP6

401

Q13023
KGNGGKRQMVDLKPE

AKAP6

406

Q13023
AVMKNKEKPSGRGRG

PNMA5

336

Q96PV4
KESGKKQRMKGVQQG

ZC3H6

191

P61129
KEGRMKGQAFIGLPN

RNPC3

461

Q96LT9
AGGLGSQMIPGKKAK

TSPYL4

136

Q9UJ04
YSKMDQGNKKGPLGR

IK

466

Q13123
MAPKGKVGTRGKKQI

TMEM208

1

Q9BTX3
KKEKMGQPQGKSGNA

MYO18B

391

Q8IUG5
KIGIGPQRGKLLEKM

ZNF543

136

Q08ER8
KINGGEKRPASDMGK

TOX

231

O94900
GKVGRKDGQMLPGED

SF1

186

Q15637
FQGKLDRKQGIPMKE

ZKSCAN5

506

Q9Y2L8
GKDMPKVQGLLENGD

KDM5C

1341

P41229