| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | [heparan sulfate]-glucosamine N-sulfotransferase activity | 7.32e-13 | 4 | 20 | 4 | GO:0015016 | |
| GeneOntologyMolecularFunction | N-acetylglucosamine deacetylase activity | 7.32e-13 | 4 | 20 | 4 | GO:0050119 | |
| GeneOntologyMolecularFunction | heparan sulfate N-deacetylase activity | 8.59e-10 | 3 | 20 | 3 | GO:0102140 | |
| GeneOntologyMolecularFunction | heparan sulfate sulfotransferase activity | 9.92e-10 | 15 | 20 | 4 | GO:0034483 | |
| GeneOntologyMolecularFunction | deacetylase activity | 6.53e-08 | 40 | 20 | 4 | GO:0019213 | |
| GeneOntologyMolecularFunction | sulfotransferase activity | 2.41e-07 | 55 | 20 | 4 | GO:0008146 | |
| GeneOntologyMolecularFunction | transferase activity, transferring sulphur-containing groups | 8.05e-07 | 74 | 20 | 4 | GO:0016782 | |
| GeneOntologyMolecularFunction | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 1.16e-06 | 81 | 20 | 4 | GO:0016811 | |
| GeneOntologyMolecularFunction | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | 1.21e-05 | 146 | 20 | 4 | GO:0016810 | |
| GeneOntologyMolecularFunction | carboxylic ester hydrolase activity | 1.62e-05 | 157 | 20 | 4 | GO:0052689 | |
| GeneOntologyMolecularFunction | hydrolase activity, acting on ester bonds | 9.95e-04 | 807 | 20 | 5 | GO:0016788 | |
| GeneOntologyMolecularFunction | microtubule motor activity | 2.21e-03 | 70 | 20 | 2 | GO:0003777 | |
| GeneOntologyMolecularFunction | cytoskeletal motor activity | 6.14e-03 | 118 | 20 | 2 | GO:0003774 | |
| GeneOntologyBiologicalProcess | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process | 4.49e-11 | 8 | 20 | 4 | GO:0015014 | |
| GeneOntologyBiologicalProcess | heparin biosynthetic process | 2.11e-10 | 11 | 20 | 4 | GO:0030210 | |
| GeneOntologyBiologicalProcess | heparin metabolic process | 1.52e-09 | 17 | 20 | 4 | GO:0030202 | |
| GeneOntologyBiologicalProcess | proteoglycan metabolic process | 3.04e-08 | 97 | 20 | 5 | GO:0006029 | |
| GeneOntologyBiologicalProcess | heparan sulfate proteoglycan biosynthetic process | 3.30e-08 | 35 | 20 | 4 | GO:0015012 | |
| GeneOntologyBiologicalProcess | proteoglycan biosynthetic process | 5.66e-07 | 70 | 20 | 4 | GO:0030166 | |
| GeneOntologyBiologicalProcess | polysaccharide biosynthetic process | 7.88e-07 | 76 | 20 | 4 | GO:0000271 | |
| GeneOntologyBiologicalProcess | glycosaminoglycan biosynthetic process | 7.88e-07 | 76 | 20 | 4 | GO:0006024 | |
| GeneOntologyBiologicalProcess | aminoglycan biosynthetic process | 9.70e-07 | 80 | 20 | 4 | GO:0006023 | |
| GeneOntologyBiologicalProcess | mucopolysaccharide metabolic process | 2.37e-06 | 100 | 20 | 4 | GO:1903510 | |
| GeneOntologyBiologicalProcess | glycoprotein metabolic process | 2.40e-06 | 430 | 20 | 6 | GO:0009100 | |
| GeneOntologyBiologicalProcess | glycosaminoglycan metabolic process | 5.08e-06 | 121 | 20 | 4 | GO:0030203 | |
| GeneOntologyBiologicalProcess | polysaccharide metabolic process | 5.96e-06 | 126 | 20 | 4 | GO:0005976 | |
| GeneOntologyBiologicalProcess | aminoglycan metabolic process | 7.17e-06 | 132 | 20 | 4 | GO:0006022 | |
| GeneOntologyBiologicalProcess | glycoprotein biosynthetic process | 1.89e-05 | 357 | 20 | 5 | GO:0009101 | |
| GeneOntologyBiologicalProcess | sulfur compound biosynthetic process | 2.33e-05 | 178 | 20 | 4 | GO:0044272 | |
| GeneOntologyBiologicalProcess | heparan sulfate proteoglycan biosynthetic process, enzymatic modification | 5.86e-05 | 12 | 20 | 2 | GO:0015015 | |
| GeneOntologyBiologicalProcess | carbohydrate biosynthetic process | 8.36e-05 | 247 | 20 | 4 | GO:0016051 | |
| GeneOntologyBiologicalProcess | heparan sulfate proteoglycan metabolic process | 1.20e-04 | 17 | 20 | 2 | GO:0030201 | |
| GeneOntologyBiologicalProcess | skeletal system development | 2.48e-04 | 615 | 20 | 5 | GO:0001501 | |
| GeneOntologyBiologicalProcess | connective tissue development | 2.95e-04 | 343 | 20 | 4 | GO:0061448 | |
| GeneOntologyBiologicalProcess | carbohydrate metabolic process | 3.11e-04 | 646 | 20 | 5 | GO:0005975 | |
| GeneOntologyBiologicalProcess | sulfur compound metabolic process | 3.73e-04 | 365 | 20 | 4 | GO:0006790 | |
| GeneOntologyBiologicalProcess | stem cell proliferation | 4.40e-04 | 156 | 20 | 3 | GO:0072089 | |
| GeneOntologyBiologicalProcess | carbohydrate derivative biosynthetic process | 5.66e-04 | 736 | 20 | 5 | GO:1901137 | |
| GeneOntologyBiologicalProcess | carbohydrate derivative metabolic process | 8.20e-04 | 1226 | 20 | 6 | GO:1901135 | |
| GeneOntologyBiologicalProcess | antiviral innate immune response | 1.33e-03 | 56 | 20 | 2 | GO:0140374 | |
| GeneOntologyBiologicalProcess | cartilage development | 1.59e-03 | 243 | 20 | 3 | GO:0051216 | |
| GeneOntologyCellularComponent | Golgi membrane | 4.22e-05 | 721 | 20 | 6 | GO:0000139 | |
| Domain | HSNSD | 9.56e-13 | 4 | 20 | 4 | PF12062 | |
| Domain | Heparan_SO4_deacetylase | 9.56e-13 | 4 | 20 | 4 | IPR021930 | |
| Domain | Sulfotransferase_dom | 5.51e-08 | 36 | 20 | 4 | IPR000863 | |
| Domain | Sulfotransfer_1 | 5.51e-08 | 36 | 20 | 4 | PF00685 | |
| Domain | P-loop_NTPase | 1.93e-04 | 848 | 20 | 6 | IPR027417 | |
| Domain | - | 9.43e-04 | 746 | 20 | 5 | 3.40.50.300 | |
| Domain | - | 1.16e-02 | 449 | 20 | 3 | 3.30.40.10 | |
| Domain | Znf_RING/FYVE/PHD | 1.23e-02 | 459 | 20 | 3 | IPR013083 | |
| Domain | Znf_C3HC4_RING-type | 1.44e-02 | 172 | 20 | 2 | IPR018957 | |
| Domain | Homeobox_CS | 1.67e-02 | 186 | 20 | 2 | IPR017970 | |
| Pathway | KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS | 2.00e-10 | 11 | 14 | 4 | M47921 | |
| Pathway | KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE | 8.99e-09 | 26 | 14 | 4 | M7330 | |
| Pathway | REACTOME_HS_GAG_BIOSYNTHESIS | 1.43e-08 | 29 | 14 | 4 | MM14802 | |
| Pathway | REACTOME_HS_GAG_BIOSYNTHESIS | 1.89e-08 | 31 | 14 | 4 | M685 | |
| Pathway | WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS | 6.03e-08 | 41 | 14 | 4 | M48095 | |
| Pathway | REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM | 1.87e-07 | 54 | 14 | 4 | MM14633 | |
| Pathway | REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM | 2.33e-07 | 57 | 14 | 4 | M692 | |
| Pathway | REACTOME_GLYCOSAMINOGLYCAN_METABOLISM | 5.16e-06 | 123 | 14 | 4 | MM14623 | |
| Pathway | REACTOME_GLYCOSAMINOGLYCAN_METABOLISM | 5.68e-06 | 126 | 14 | 4 | M695 | |
| Pathway | WP_METAPATHWAY_BIOTRANSFORMATION | 1.23e-05 | 153 | 14 | 4 | MM15844 | |
| Pathway | WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II | 2.48e-05 | 183 | 14 | 4 | M39588 | |
| Pathway | REACTOME_METABOLISM_OF_CARBOHYDRATES | 1.15e-04 | 271 | 14 | 4 | MM15406 | |
| Pathway | REACTOME_METABOLISM_OF_CARBOHYDRATES | 1.45e-04 | 288 | 14 | 4 | M16864 | |
| Pathway | REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS | 2.01e-03 | 68 | 14 | 2 | M27303 | |
| Pubmed | 7.95e-14 | 4 | 20 | 4 | 22049073 | ||
| Pubmed | 7.95e-14 | 4 | 20 | 4 | 12070138 | ||
| Pubmed | 3.97e-13 | 5 | 20 | 4 | 11087757 | ||
| Pubmed | FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling. | 5.56e-12 | 8 | 20 | 4 | 24067353 | |
| Pubmed | Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain. | 2.62e-11 | 11 | 20 | 4 | 15944372 | |
| Pubmed | 3.92e-11 | 12 | 20 | 4 | 12460940 | ||
| Pubmed | 1.63e-10 | 3 | 20 | 3 | 9915799 | ||
| Pubmed | Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. | 3.83e-10 | 20 | 20 | 4 | 17107998 | |
| Pubmed | NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development. | 5.78e-10 | 22 | 20 | 4 | 19299468 | |
| Pubmed | 6.50e-10 | 4 | 20 | 3 | 29688404 | ||
| Pubmed | 6.50e-10 | 4 | 20 | 3 | 16056228 | ||
| Pubmed | Altered heparan sulfate structure in mice with deleted NDST3 gene function. | 5.68e-09 | 7 | 20 | 3 | 18385133 | |
| Pubmed | 1.29e-07 | 81 | 20 | 4 | 39217171 | ||
| Pubmed | 3.14e-07 | 2 | 20 | 2 | 8144627 | ||
| Pubmed | 3.14e-07 | 2 | 20 | 2 | 9565617 | ||
| Pubmed | Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells. | 3.14e-07 | 2 | 20 | 2 | 22298785 | |
| Pubmed | 3.14e-07 | 2 | 20 | 2 | 15319440 | ||
| Pubmed | 3.14e-07 | 2 | 20 | 2 | 16984905 | ||
| Pubmed | N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. | 3.14e-07 | 2 | 20 | 2 | 23060443 | |
| Pubmed | 3.14e-07 | 2 | 20 | 2 | 10758005 | ||
| Pubmed | 3.14e-07 | 2 | 20 | 2 | 12634318 | ||
| Pubmed | Heparin/heparan sulfate biosynthesis: processive formation of N-sulfated domains. | 3.14e-07 | 2 | 20 | 2 | 18487608 | |
| Pubmed | 3.14e-07 | 2 | 20 | 2 | 12417402 | ||
| Pubmed | 9.42e-07 | 3 | 20 | 2 | 18479348 | ||
| Pubmed | 9.42e-07 | 3 | 20 | 2 | 22345168 | ||
| Pubmed | Heparan sulfate structure in mice with genetically modified heparan sulfate production. | 1.88e-06 | 4 | 20 | 2 | 15292174 | |
| Pubmed | 3.14e-06 | 5 | 20 | 2 | 17289920 | ||
| Pubmed | 4.71e-06 | 6 | 20 | 2 | 19915053 | ||
| Pubmed | Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate. | 6.59e-06 | 7 | 20 | 2 | 35608020 | |
| Pubmed | Genetic epistasis between heparan sulfate and FGF-Ras signaling controls lens development. | 1.13e-05 | 9 | 20 | 2 | 21536023 | |
| Pubmed | A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. | 1.13e-05 | 9 | 20 | 2 | 30377379 | |
| Pubmed | Functional and topological characteristics of mammalian regulatory domains. | 1.72e-05 | 11 | 20 | 2 | 24398455 | |
| Pubmed | 1.85e-05 | 90 | 20 | 3 | 30228991 | ||
| Pubmed | 2.07e-05 | 12 | 20 | 2 | 18077586 | ||
| Pubmed | 3.28e-05 | 15 | 20 | 2 | 19464179 | ||
| Pubmed | Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity. | 5.34e-05 | 19 | 20 | 2 | 27453501 | |
| Pubmed | Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos. | 5.34e-05 | 19 | 20 | 2 | 23763947 | |
| Pubmed | 5.93e-05 | 20 | 20 | 2 | 22745308 | ||
| Pubmed | Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis. | 5.93e-05 | 20 | 20 | 2 | 24753163 | |
| Pubmed | 8.61e-05 | 24 | 20 | 2 | 34653670 | ||
| Pubmed | Compartment-dependent activities of Wnt3a/β-catenin signaling during vertebrate axial extension. | 1.09e-04 | 27 | 20 | 2 | 25152336 | |
| Pubmed | Specification of jaw identity by the Hand2 transcription factor. | 1.18e-04 | 28 | 20 | 2 | 27329940 | |
| Pubmed | 1.35e-04 | 30 | 20 | 2 | 12676797 | ||
| Pubmed | 1.35e-04 | 30 | 20 | 2 | 32324134 | ||
| Pubmed | 1.96e-04 | 985 | 20 | 5 | 12975309 | ||
| Pubmed | 2.07e-04 | 37 | 20 | 2 | 32201365 | ||
| Pubmed | NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo. | 2.42e-04 | 40 | 20 | 2 | 26534985 | |
| Pubmed | 2.42e-04 | 40 | 20 | 2 | 21256124 | ||
| Pubmed | 4.09e-04 | 52 | 20 | 2 | 28893950 | ||
| Pubmed | ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. | 5.27e-04 | 59 | 20 | 2 | 31924792 | |
| Interaction | NDST4 interactions | 4.67e-08 | 8 | 20 | 3 | int:NDST4 | |
| Interaction | NDST3 interactions | 6.99e-08 | 9 | 20 | 3 | int:NDST3 | |
| Interaction | NDST1 interactions | 4.90e-06 | 34 | 20 | 3 | int:NDST1 | |
| Interaction | NDST2 interactions | 9.36e-06 | 42 | 20 | 3 | int:NDST2 | |
| Cytoband | 17q22 | 1.69e-04 | 44 | 20 | 2 | 17q22 | |
| Cytoband | 4q26 | 1.69e-04 | 44 | 20 | 2 | 4q26 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr4q26 | 2.64e-04 | 55 | 20 | 2 | chr4q26 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr17q22 | 6.75e-04 | 88 | 20 | 2 | chr17q22 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr7p22 | 1.55e-03 | 134 | 20 | 2 | chr7p22 | |
| GeneFamily | Sulfotransferases, membrane bound | 3.47e-08 | 37 | 17 | 4 | 763 | |
| Disease | azoospermia (implicated_via_orthology) | 2.13e-09 | 27 | 19 | 4 | DOID:14227 (implicated_via_orthology) | |
| Disease | intellectual disability (implicated_via_orthology) | 1.45e-07 | 75 | 19 | 4 | DOID:1059 (implicated_via_orthology) | |
| Disease | autism spectrum disorder (implicated_via_orthology) | 2.47e-06 | 152 | 19 | 4 | DOID:0060041 (implicated_via_orthology) | |
| Disease | aseptic loosening, revision of total knee arthroplasty | 3.33e-04 | 42 | 19 | 2 | EFO_0010725, EFO_0020972 | |
| Disease | primary immunodeficiency disease (is_implicated_in) | 3.33e-04 | 42 | 19 | 2 | DOID:612 (is_implicated_in) | |
| Disease | Prostatic Neoplasms | 5.68e-04 | 616 | 19 | 4 | C0033578 | |
| Disease | Malignant neoplasm of prostate | 5.68e-04 | 616 | 19 | 4 | C0376358 | |
| Disease | peak expiratory flow | 3.79e-03 | 498 | 19 | 3 | EFO_0009718 | |
| Disease | stroke | 3.83e-03 | 144 | 19 | 2 | EFO_0000712 | |
| Disease | chronic kidney disease | 9.88e-03 | 235 | 19 | 2 | EFO_0003884 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| HVPLHYYPHVGVTAA | 281 | Q03828 | |
| PEHYIFSPFGILHVH | 321 | Q96M86 | |
| KHPLVEGGYHPHIVY | 181 | P58397 | |
| YYPVIFHRRGHHGCP | 186 | Q6UXT9 | |
| HPGEHEVGEPEFHYI | 361 | Q8N436 | |
| APHHSGVYPVHVQLY | 421 | O95803 | |
| LIQHPGIHYPPLHYA | 116 | P0C7T5 | |
| GYAVAPHHSGVYPVH | 426 | P52848 | |
| PHHSGVYPVHVQLYE | 431 | P52848 | |
| GYAVAPHHSGVYPVH | 416 | Q9H3R1 | |
| PHHSGVYPVHIQLYA | 421 | Q9H3R1 | |
| GYIGTHEYPHFSHRP | 366 | P00973 | |
| GFPHHPVVHHEGYPF | 6 | P61296 | |
| FHPFVPEHHLIKGYL | 266 | Q9NS00 | |
| DVRPYHRGHYPIGHE | 546 | Q8N4N8 | |
| PGHAHYHLPAAYLLG | 346 | Q68DV7 | |
| YAVAPHHSGVYPIHT | 426 | P52849 | |
| CSHGGIPPHKYHYID | 736 | Q9Y2K6 | |
| HPAVGVAGYHSPYLH | 496 | Q9ULC8 | |
| PVAGHPHRIGLYLHY | 406 | Q86XT4 | |
| FHNGDYPGEPFILHH | 556 | P08575 | |
| VVGFPYPLGHHHVYE | 21 | A6NJT0 |