Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprocollagen-proline 4-dioxygenase activity

P4HA2 P4HA3

1.10e-045672GO:0004656
GeneOntologyMolecularFunctionpeptidyl-proline 4-dioxygenase activity

P4HA2 P4HA3

3.07e-048672GO:0031545
GeneOntologyMolecularFunctionprocollagen-proline dioxygenase activity

P4HA2 P4HA3

3.07e-048672GO:0019798
GeneOntologyBiologicalProcesspeptidyl-threonine phosphorylation

CDC42BPA TBK1 MARK2 TSSK4 CDC42BPB

3.36e-05115665GO:0018107
GeneOntologyBiologicalProcesspeptidyl-threonine modification

CDC42BPA TBK1 MARK2 TSSK4 CDC42BPB

5.02e-05125665GO:0018210
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

FKBP10 P4HA2 CDC42BPA IKBKE NTRK2 TBK1 DDR2 P4HA3 MARK2 TSSK4 CDC42BPB DPH6

5.45e-059766612GO:0018193
GeneOntologyBiologicalProcessprotein hydroxylation

FKBP10 P4HA2 P4HA3

9.68e-0528663GO:0018126
HumanPhenoIncoordination

ELOVL4 P4HA2 ABCA2 TSPOAP1 ERAP1 OTUD6B NTRK2 TBK1 KCNJ16 GBE1 TTI1 FGF12 ACTL6B HUWE1 CERS1 USH2A GBA2 CDC42BPB TARS1 TOP3A

1.53e-0511843520HP:0002311
HumanPhenoAppendicular spasticity

ELOVL4 AP4E1 TSPOAP1 OTUD6B NTRK2 TBK1 GBE1 TTI1 ACTL6B ODC1 HUWE1 GBA2

1.75e-054353512HP:0034353
HumanPhenoAbnormality of coordination

ELOVL4 P4HA2 ABCA2 TSPOAP1 ERAP1 OTUD6B NTRK2 TBK1 KCNJ16 GBE1 TTI1 FGF12 ACTL6B HUWE1 CERS1 USH2A GBA2 CDC42BPB TARS1 TOP3A

2.69e-0512273520HP:0011443
HumanPhenoAtaxia

ELOVL4 P4HA2 ABCA2 TSPOAP1 ERAP1 OTUD6B NTRK2 TBK1 KCNJ16 GBE1 TTI1 FGF12 ACTL6B CERS1 USH2A GBA2 TARS1 TOP3A

6.62e-0510733518HP:0001251
DomainKELK

CDC42BPA CDC42BPB

1.31e-052682IPR031597
DomainKELK

CDC42BPA CDC42BPB

1.31e-052682PF15796
DomainP4Ha_N

P4HA2 P4HA3

3.91e-053682PF08336
DomainPro_4_hyd_alph_N

P4HA2 P4HA3

3.91e-053682IPR013547
DomainMyotonic_dystrophy_kinase_coil

CDC42BPA CDC42BPB

7.80e-054682IPR014930
DomainMyotonic_dystrophy_kinase_coil

CDC42BPA CDC42BPB

7.80e-054682PD011252
DomainDMPK_coil

CDC42BPA CDC42BPB

7.80e-054682PF08826
DomainProt_kinase_dom

CDC42BPA IKBKE NTRK2 TBK1 DDR2 MARK2 TSSK4 CDC42BPB

3.89e-04489688IPR000719
DomainPROTEIN_KINASE_DOM

CDC42BPA IKBKE NTRK2 TBK1 DDR2 MARK2 TSSK4 CDC42BPB

4.10e-04493688PS50011
DomainProtein_kinase_ATP_BS

CDC42BPA IKBKE NTRK2 TBK1 MARK2 TSSK4 CDC42BPB

4.48e-04379687IPR017441
Domain2OG-FeII_Oxy_3

P4HA2 P4HA3

7.03e-0411682PF13640
DomainTyr_kinase_rcpt_2_CS

NTRK2 DDR2

7.03e-0411682IPR002011
DomainKinase-like_dom

CDC42BPA IKBKE NTRK2 TBK1 DDR2 MARK2 TSSK4 CDC42BPB

7.65e-04542688IPR011009
DomainRECEPTOR_TYR_KIN_II

NTRK2 DDR2

8.42e-0412682PS00239
DomainCNH

CDC42BPA CDC42BPB

1.16e-0314682SM00036
DomainCNH

CDC42BPA CDC42BPB

1.33e-0315682PF00780
DomainCNH

CDC42BPA CDC42BPB

1.33e-0315682PS50219
DomainCNH_dom

CDC42BPA CDC42BPB

1.33e-0315682IPR001180
DomainPROTEIN_KINASE_ATP

CDC42BPA IKBKE NTRK2 TBK1 MARK2 TSSK4 CDC42BPB

1.38e-03459687PS00107
DomainP4Hc

P4HA2 P4HA3

1.52e-0316682SM00702
DomainPro_4_hyd_alph

P4HA2 P4HA3

1.52e-0316682IPR006620
DomainPBD

CDC42BPA CDC42BPB

1.52e-0316682SM00285
DomainSer/Thr_kinase_AS

CDC42BPA IKBKE TBK1 MARK2 TSSK4 CDC42BPB

1.89e-03357686IPR008271
DomainZn_pept

CPO CPD

1.92e-0318682SM00631
DomainS_TKc

CDC42BPA IKBKE TBK1 MARK2 TSSK4 CDC42BPB

1.94e-03359686SM00220
DomainPROTEIN_KINASE_ST

CDC42BPA IKBKE TBK1 MARK2 TSSK4 CDC42BPB

2.03e-03362686PS00108
DomainCARBOXYPEPT_ZN_2

CPO CPD

2.15e-0319682PS00133
Domain2OG-FeII_Oxy

P4HA2 P4HA3

2.15e-0319682PF03171
DomainCRIB

CDC42BPA CDC42BPB

2.38e-0320682PS50108
DomainCARBOXYPEPT_ZN_1

CPO CPD

2.38e-0320682PS00132
DomainPkinase

CDC42BPA IKBKE TBK1 MARK2 TSSK4 CDC42BPB

2.62e-03381686PF00069
DomainFE2OG_OXY

P4HA2 P4HA3

2.62e-0321682PS51471
DomainCRIB_dom

CDC42BPA CDC42BPB

2.62e-0321682IPR000095
Domainfn3

PRTG TSPOAP1 PTPRS USH2A

2.89e-03162684PF00041
DomainTPR_REGION

TTC7A P4HA2 P4HA3 TTC6

3.08e-03165684PS50293
DomainTPR

TTC7A P4HA2 P4HA3 TTC6

3.08e-03165684PS50005
DomainPeptidase_M14

CPO CPD

3.15e-0323682PF00246
DomainPeptidase_M14

CPO CPD

3.15e-0323682IPR000834
DomainOxoglu/Fe-dep_dioxygenase

P4HA2 P4HA3

3.15e-0323682IPR005123
DomainEF-hand_5

FKBP10 CALU

3.71e-0325682PF13202
DomainFN3

PRTG TSPOAP1 PTPRS USH2A

4.63e-03185684SM00060
DomainUBA

HUWE1 MARK2

5.32e-0330682SM00165
DomainFN3

PRTG TSPOAP1 PTPRS USH2A

5.99e-03199684PS50853
DomainIg_E-set

KCNJ16 CD109 GBE1

6.47e-03104683IPR014756
DomainFN3_dom

PRTG TSPOAP1 PTPRS USH2A

7.10e-03209684IPR003961
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

FKBP10 P4HA2 ABCA2 EMC1 ERAP1 PTPRS CALU CD109 TTI1 P4HA3 CPD CERS1

3.32e-061201681235696571
Pubmed

Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes.

IKBKE TBK1

3.77e-06268227123832
Pubmed

IKKε and TBK1 expression in gastric cancer.

IKBKE TBK1

3.77e-06268227145266
Pubmed

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells.

IKBKE TBK1

3.77e-06268230349097
Pubmed

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.

IKBKE TBK1

3.77e-06268215367631
Pubmed

IKKε and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling.

IKBKE TBK1

3.77e-06268232858764
Pubmed

Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.

IKBKE TBK1

3.77e-06268230082428
Pubmed

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.

IKBKE TBK1

3.77e-06268216888014
Pubmed

Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.

IKBKE TBK1

3.77e-06268236936901
Pubmed

Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.

IKBKE TBK1

3.77e-06268223096996
Pubmed

Cloning and chromosomal localization of human Cdc42-binding protein kinase beta.

CDC42BPA CDC42BPB

3.77e-06268210198171
Pubmed

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.

IKBKE TBK1

3.77e-06268215210742
Pubmed

Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.

IKBKE TBK1

3.77e-06268217056502
Pubmed

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.

IKBKE TBK1

3.77e-06268222619329
Pubmed

The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.

IKBKE TBK1

3.77e-06268230504235
Pubmed

Functionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN production.

IKBKE TBK1

3.77e-06268224722368
Pubmed

Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.

CDC42BPA CDC42BPB

3.77e-06268218263588
Pubmed

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

IKBKE TBK1

3.77e-06268218353649
Pubmed

The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs.

IKBKE TBK1

3.77e-06268223157677
Pubmed

Crystal structure and mechanism of activation of TANK-binding kinase 1.

IKBKE TBK1

3.77e-06268223453971
Pubmed

Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.

IKBKE TBK1

1.13e-05368229755980
Pubmed

ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.

IKBKE TBK1

1.13e-05368222787218
Pubmed

Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer.

P4HA2 P4HA3

1.13e-05368234387118
Pubmed

Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform.

IKBKE TBK1

1.13e-05368224706939
Pubmed

HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression.

IKBKE TBK1

1.13e-05368225531185
Pubmed

Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.

IKBKE TBK1

1.13e-05368217327220
Pubmed

TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.

IKBKE TBK1

1.13e-05368234518217
Pubmed

SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity.

IKBKE TBK1

1.13e-05368225939384
Pubmed

Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.

IKBKE TBK1

1.13e-05368216380379
Pubmed

Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.

IKBKE TBK1

1.13e-05368231662325
Pubmed

Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies.

IKBKE TBK1

1.13e-05368224335286
Pubmed

Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.

IKBKE TBK1

1.13e-05368234260286
Pubmed

IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.

IKBKE TBK1

1.13e-05368211839743
Pubmed

The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.

IKBKE TBK1

1.13e-05368232220666
Pubmed

A20 is a negative regulator of IFN regulatory factor 3 signaling.

IKBKE TBK1

1.13e-05368215661910
Pubmed

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.

IKBKE TBK1

1.13e-05368224368730
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

FKBP10 ABCA2 EMC1 ERAP1 CD109

1.80e-0516468532409323
Pubmed

Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS.

IKBKE TBK1

2.25e-05468237967220
Pubmed

Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype.

IKBKE TBK1

2.25e-05468235289316
Pubmed

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.

IKBKE TBK1

2.25e-05468232268090
Pubmed

SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.

IKBKE TBK1

2.25e-05468216281057
Pubmed

Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain.

IKBKE TBK1

2.25e-05468224509444
Pubmed

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.

IKBKE TBK1

2.25e-05468224562310
Pubmed

A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.

CDC42BPA CDC42BPB

2.25e-05468218854160
Pubmed

Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme.

P4HA2 P4HA3

2.25e-05468214500733
Pubmed

Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.

IKBKE TBK1

2.25e-05468219153231
Pubmed

IKKε and TBK1 prevent RIPK1 dependent and independent inflammation.

IKBKE TBK1

2.25e-05468238167258
Pubmed

Estrogen receptor alpha inhibits RLR-mediated immune response via ubiquitinating TRAF3.

IKBKE TBK1

2.25e-05468226186972
Pubmed

TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.

IKBKE TBK1

2.25e-05468228011935
Pubmed

A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.

IKBKE TBK1

2.25e-05468215556946
Pubmed

The E3 Ubiquitin Ligase TBK1 Mediates the Degradation of Multiple Picornavirus VP3 Proteins by Phosphorylation and Ubiquitination.

IKBKE TBK1

2.25e-05468231534043
Pubmed

Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.

CDC42BPA CDC42BPB

2.25e-0546829418861
Pubmed

Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.

IKBKE TBK1

2.25e-05468218467330
Pubmed

Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1.

IKBKE TBK1

2.25e-05468227705791
Pubmed

Functional dissection of the TBK1 molecular network.

IKBKE TBK1

2.25e-05468221931631
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

EMC1 PTPRS CALU TTI1 CPD HUWE1 HNRNPF CDC45

2.60e-0561368822268729
Pubmed

Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays.

OTUD6B TBK1 FGF12 MARK2

2.63e-058768420804422
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

EMC1 CDC42BPA PTPRS CALU PPP1R9A DHX38 TTI1 CPD HUWE1 CDC42BPB

3.55e-051049681027880917
Pubmed

TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.

IKBKE TBK1

3.75e-05568222851696
Pubmed

IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.

IKBKE TBK1

3.75e-05568222072751
Pubmed

The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members.

IKBKE TBK1

3.75e-05568216393995
Pubmed

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

IKBKE TBK1

3.75e-05568221464307
Pubmed

Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.

IKBKE TBK1

3.75e-05568234257412
Pubmed

RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.

IKBKE TBK1

3.75e-05568223308279
Pubmed

A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3.

IKBKE TBK1

3.75e-05568223396947
Pubmed

Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.

IKBKE TBK1

3.75e-05568217015689
Pubmed

The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.

IKBKE TBK1

3.75e-05568217468758
Pubmed

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.

IKBKE TBK1

3.75e-05568222007846
Pubmed

The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING.

IKBKE TBK1

3.75e-05568237130168
Pubmed

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.

IKBKE TBK1

3.75e-05568220389019
Pubmed

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.

P4HA2 P4HA3

3.75e-05568216885164
Pubmed

A role for APPL1 in TLR3/4-dependent TBK1 and IKKε activation in macrophages.

IKBKE TBK1

3.75e-05568225780039
Pubmed

Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.

IKBKE TBK1

3.75e-05568216914100
Pubmed

Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.

IKBKE TBK1

3.75e-05568225606824
Pubmed

Developmental and regional expression and localization of mRNAs encoding proteins involved in RNA translocation.

MAGOH SI

5.62e-05668216009965
Pubmed

ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.

IKBKE TBK1

5.62e-05668221885437
Pubmed

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex.

IKBKE TBK1

5.62e-05668224622840
Pubmed

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.

IKBKE TBK1

5.62e-05668215695821
Pubmed

NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.

IKBKE TBK1

5.62e-05668217142768
Pubmed

UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS.

IKBKE TBK1

5.62e-05668236943869
Pubmed

Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.

IKBKE TBK1

5.62e-05668214560022
Pubmed

Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus.

IKBKE TBK1

5.62e-05668232511263
Pubmed

SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1.

IKBKE TBK1

5.62e-05668234084167
Pubmed

FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.

IKBKE TBK1

5.62e-05668233822771
Pubmed

Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.

CDC42BPA CDC42BPB

5.62e-05668225107909
Pubmed

Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity.

IKBKE TBK1

5.62e-05668234239064
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

EMC1 CDC42BPA TSPOAP1 NTRK2 APBA1 ACTL6B HUWE1 CDC42BPB SHISA7 CNOT2

7.07e-051139681036417873
Pubmed

MCPIP1 negatively regulate cellular antiviral innate immune responses through DUB and disruption of TRAF3-TBK1-IKKε complex.

IKBKE TBK1

7.86e-05768229920243
Pubmed

IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling.

IKBKE TBK1

7.86e-05768229563620
Pubmed

Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.

IKBKE TBK1

7.86e-05768229251827
Pubmed

A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.

IKBKE TBK1

7.86e-05768223950712
Pubmed

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

IKBKE TBK1

7.86e-05768218636086
Pubmed

TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-β signaling pathway.

IKBKE TBK1

7.86e-05768237023504
Pubmed

Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression.

IKBKE TBK1

7.86e-05768222252317
Pubmed

MIP-T3 is a negative regulator of innate type I IFN response.

IKBKE TBK1

7.86e-05768222079989
Pubmed

Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.

IKBKE TBK1

7.86e-05768219380580
Pubmed

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene.

IKBKE TBK1

7.86e-05768227129230
Pubmed

MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.

CDC42BPA CDC42BPB

7.86e-05768229162624
Pubmed

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

IKBKE TBK1

7.86e-05768212692549
Pubmed

E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.

IKBKE TBK1

7.86e-05768232298923
InteractionFBXO6 interactions

FKBP10 ABCA2 EMC1 ERAP1 PTPRS CALU CD109 TTI1 CPD HUWE1 HNRNPF CDC45

3.17e-067176612int:FBXO6
InteractionZC3H12A interactions

IKBKE TBK1 RAVER2 P4HA3

6.39e-0637664int:ZC3H12A
InteractionTMEM106B interactions

FKBP10 P4HA2 EMC1 ERAP1 CALU CD109 CPD HUWE1

7.41e-06309668int:TMEM106B
GeneFamilyFibronectin type III domain containing

PRTG TSPOAP1 PTPRS USH2A

5.09e-04160424555
GeneFamilyCarboxypeptidases

CPO CPD

1.08e-03214221321
GeneFamilyReceptor Tyrosine Kinases|CD molecules

NTRK2 DDR2

3.89e-0340422321
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PRTG PTPRS NTRK2

6.17e-03161423593
ToppCelldroplet-Fat-Scat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT P4HA2 NTRK2 DDR2 CD109 P4HA3

1.86e-08193687316ebdf15f75d88c348f909b643fcd315364ca84
ToppCellFibroblasts-DKK3+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

FKBP10 DPT P4HA2 CDC42BPA MAMDC2 DDR2 CD109

2.22e-081986874f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCellFibroblast|World / shred by cell class for parenchyma

FKBP10 DPT P4HA2 MAMDC2 TNFSF13B DDR2 SVEP1

2.38e-08200687dec9ce1bc2571197003596f32e5f742ede72aa79
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRTG CD109 APBA1 P4HA3 FGF12 SHISA7

2.94e-071766865e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteoblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 DPT PRTG PTPRS MAMDC2 DDR2

3.59e-07182686ba066ff9029cc052b76e2330ec168cb2e9b7e498
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FKBP10 PTPRS MAMDC2 DDR2 ODC1 ABTB2

3.70e-071836867eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

FKBP10 DPT PTPRS MAMDC2 DDR2 SVEP1

3.82e-071846862b7e6f91e11c228f0521e099886867d9e998e78d
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT PTPRS MAMDC2 DDR2 SVEP1

4.47e-07189686d531399749409d614adca13d181830c6e3287508
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FKBP10 PTPRS MAMDC2 DDR2 ABTB2 SVEP1

4.76e-0719168614057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellfacs-Aorta-Heart-18m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT TNFSF13B NTRK2 DDR2 SVEP1

4.76e-071916866242f83acaf1714e9c1771a832cb67674b19e96d
ToppCellfacs-Aorta-Heart-18m-Mesenchymal|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT TNFSF13B NTRK2 DDR2 SVEP1

4.91e-071926866d4fe7ea278efa4b9d43f8a3c282bc0e0e9abaea
ToppCellfacs-Aorta-Heart-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT TNFSF13B NTRK2 DDR2 SVEP1

4.91e-071926862c6406bc97c3224099b94a43f2890f057b528fa6
ToppCellfacs-Aorta-Heart-18m-Mesenchymal-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT TNFSF13B NTRK2 DDR2 SVEP1

4.91e-0719268647aed7c8e6f5ce1084821212a04f568319e65fd6
ToppCelldroplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT NTRK2 DDR2 CD109 P4HA3

5.06e-071936861afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCelldroplet-Fat-Scat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT NTRK2 DDR2 CD109 P4HA3

5.06e-071936868dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCellfacs-SCAT-Fat-3m-Mesenchymal|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT P4HA2 CALU NTRK2 DDR2

5.21e-0719468614b614f039bc866a1348a2728a68b7d254c7748c
ToppCellfacs-SCAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT P4HA2 CALU NTRK2 DDR2

5.21e-0719468668c7bfead1158641928cc276f599b4a79e06c73c
ToppCellfacs-SCAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT P4HA2 CALU NTRK2 DDR2

5.21e-07194686f6aeae6a1e4017e341323fd4784c9e3bae00552b
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT CALU NTRK2 DDR2 SVEP1

5.37e-0719568669a29d03e664b72f32d41876510c62345c3aed31
ToppCellfacs-GAT-Fat-3m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT CALU NTRK2 DDR2 SVEP1

5.37e-071956861cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT CALU NTRK2 DDR2 SVEP1

5.37e-071956869cef6f18664518060af7c192310dddce6d70345a
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteoblast_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 DPT PRTG MAMDC2 DDR2 SVEP1

5.70e-071976862f72fd9a5b6d62c24a95ed2246194ea7458c0f12
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 DPT PRTG MAMDC2 DDR2 SVEP1

6.05e-07199686d65ee89d5c7e8ed693d58e6a6de09565840e11c5
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MROH9 NTRK2 PPP1R9A FGF12 SHISA7 HYDIN

6.05e-0719968619a97e27a4758e794ce7246d295e112b47931a48
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 DPT PRTG MAMDC2 DDR2 SVEP1

6.05e-07199686bf138cc692df727e087d140c014149ee5da00d9d
ToppCell390C-Fibroblasts-Fibroblast-H-|390C / Donor, Lineage, Cell class and subclass (all cells)

FKBP10 DPT P4HA2 PTPRS DDR2 SVEP1

6.23e-07200686ec7d6a08e34bcad5b3bbff56ebef96ae17e4cefd
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT P4HA2 MAMDC2 DDR2 SVEP1

6.23e-0720068617ffdbc13332bd3ed1d54abcd7af20267dd4b234
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT P4HA2 MAMDC2 DDR2 SVEP1

6.23e-07200686665df8391d2ebcfc6536318612f4992852b5e2b8
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT P4HA2 MAMDC2 DDR2 SVEP1

6.23e-072006865c6520dc4c4693827f6680651785680b5883afb8
ToppCell390C-Fibroblasts-Fibroblast-H|390C / Donor, Lineage, Cell class and subclass (all cells)

FKBP10 DPT P4HA2 PTPRS DDR2 SVEP1

6.23e-07200686671e731977c58a0c44c36b56422085d93d999aad
ToppCell368C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

EMC1 NTRK2 RAVER2 FGF12 SVEP1

4.11e-061566854877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCell368C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

EMC1 NTRK2 RAVER2 FGF12 SVEP1

4.11e-061566851d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCellAdult-Mesenchymal-chondrocyte|Adult / Lineage, Cell type, age group and donor

FKBP10 PTPRS MAMDC2 DDR2 SVEP1

4.51e-061596853f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRTG CD109 APBA1 P4HA3 SHISA7

6.61e-061726853f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)|343B / Donor, Lineage, Cell class and subclass (all cells)

ELOVL4 FKBP10 DPT MAMDC2 DDR2

7.59e-06177685e55d21d4d61a069b9bbe0e7595fbfb7cfbacfd87
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ELOVL4 FKBP10 DPT MAMDC2 DDR2

7.59e-0617768543ba6f12c2fb32698a420bf799d46ac1b558f146
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRTG CD109 P4HA3 FGF12 SHISA7

7.59e-0617768514fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT TNFSF13B NTRK2 DDR2 SVEP1

8.93e-061836855cfcd589a480e67654d3d94e71916f122150db10
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT TNFSF13B NTRK2 DDR2 SVEP1

8.93e-06183685c3ea8d3b916ffcaca3156e0d77a952724554c4ab
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT TNFSF13B NTRK2 DDR2 SVEP1

8.93e-0618368581003ddc24164959dd41bb12fcac72638789b8f2
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT NTRK2 DDR2 SVEP1

9.41e-06185685785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT NTRK2 DDR2 SVEP1

9.41e-0618568597a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT NTRK2 DDR2 SVEP1

9.66e-0618668594d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

DPT MAMDC2 DDR2 ABTB2 SVEP1

9.91e-061876854ea486991f66c29728d127171a07b81404ec0b78
ToppCellfacs-Lung-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT MAMDC2 TNFSF13B DDR2 SVEP1

1.04e-05189685bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT MAMDC2 TNFSF13B DDR2 SVEP1

1.04e-0518968540cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT MAMDC2 TNFSF13B DDR2 SVEP1

1.10e-05191685094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FKBP10 DPT P4HA2 NTRK2 DDR2

1.10e-05191685053b3664f509baa107feaf90730f80ebf9ac8f14
ToppCellfacs-Lung-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT MAMDC2 TNFSF13B DDR2 SVEP1

1.10e-05191685ba02cbdfda6a94374a6472eb88499059979af472
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT MAMDC2 TNFSF13B DDR2 SVEP1

1.10e-0519168580484d39f34703a33b9bac09826b7a526e883cab
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT PRTG PPP1R9A P4HA3

1.10e-051916859d3fa8d8138700640cc7927521c7635299df697d
ToppCell15-Trachea-Epithelial-Submucosal_gland_basal|Trachea / Age, Tissue, Lineage and Cell class

FKBP10 CALU MAMDC2 NTRK2 ABTB2

1.10e-05191685409e12d2bb26b6d2ed025304ca6ace07df16638a
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT PRTG PPP1R9A P4HA3

1.10e-05191685d04ed1e04b8cb904237d8e8388fe7740c724237b
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT MAMDC2 TNFSF13B DDR2 SVEP1

1.10e-05191685997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FKBP10 DPT NTRK2 DDR2 SVEP1

1.13e-051926858d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FKBP10 DPT P4HA2 CALU SVEP1

1.13e-05192685f053b89bfd6048c227667ff01c38df7c51d8a496
ToppCellRV-01._Fibroblast_I|RV / Chamber and Cluster_Paper

PTPRS MAMDC2 DDR2 ABTB2 SVEP1

1.13e-05192685356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 CALU NTRK2 DDR2 SVEP1

1.13e-05192685beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCellfacs-Lung-3m-Mesenchymal|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT MAMDC2 TNFSF13B DDR2 SVEP1

1.13e-051926858df15085b35b86f39debd933284cb703c5dd63c2
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT MAMDC2 DDR2 SVEP1

1.13e-05192685c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

FKBP10 DPT NTRK2 DDR2 SVEP1

1.13e-05192685a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT MAMDC2 TNFSF13B DDR2 SVEP1

1.13e-051926855876ff75e273a48e7ad8236423fb41e4ae4c0a91
ToppCellfacs-MAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT CALU NTRK2 DDR2 SVEP1

1.15e-05193685f95b95c58a6edb8a03dd15ae166f47f9f33d8bd6
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT P4HA2 P4HA3 SVEP1

1.15e-051936855bee7abc550ddaa28cbb3b9ecaf6b924ab175de0
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

FKBP10 PTPRS MAMDC2 DDR2 SVEP1

1.15e-05193685ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

PTPRS MAMDC2 DDR2 ABTB2 SVEP1

1.15e-05193685dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCellfacs-MAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT CALU NTRK2 DDR2 SVEP1

1.15e-0519368585faf6c5ce4769615a4eca036e2ba307e176bb52
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT CALU NTRK2 DDR2 SVEP1

1.15e-0519368525248b8e65d558b1a96a87c93e3e5b4c0ba168fe
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT CALU NTRK2 DDR2 SVEP1

1.15e-05193685f1f1097204e07a7bed416425b8256942038a734f
ToppCellfacs-MAT-Fat-3m-Mesenchymal|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT CALU NTRK2 DDR2 SVEP1

1.15e-05193685110a7d2ba7d066c2be38be98b643b76c520dd980
ToppCellRV-02._Fibroblast_II|RV / Chamber and Cluster_Paper

PTPRS MAMDC2 DDR2 ABTB2 SVEP1

1.18e-0519468511c79a8c56ece42713b04b321982e41e239f07a5
ToppCellfacs-BAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT NTRK2 DDR2 SVEP1

1.18e-05194685da45811ba07d746e7cba7ed78882b5d98ac7397d
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FKBP10 DPT NTRK2 DDR2 SVEP1

1.18e-05194685439d3f17c1f4736122b330e98add9292c7036a8e
ToppCellfacs-BAT-Fat-3m-Mesenchymal|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT NTRK2 DDR2 SVEP1

1.18e-0519468576b8512fd92014b3ecc42b0a20d6d1df074cba2c
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

PTPRS MAMDC2 DDR2 ABTB2 SVEP1

1.18e-05194685234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellfacs-BAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 DPT NTRK2 DDR2 SVEP1

1.18e-05194685ef0fa9daecd3bf43c6cf56345928cacdbee19779
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

PTPRS MAMDC2 DDR2 ABTB2 SVEP1

1.21e-05195685a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT PTPRS MAMDC2 SVEP1

1.21e-05195685df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT PTPRS MAMDC2 SVEP1

1.21e-051956854243190ad291d56694e2155954dbaa879c9d3844
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT MAMDC2 DDR2 SVEP1

1.21e-051956851236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCellRV-02._Fibroblast_II|World / Chamber and Cluster_Paper

PTPRS MAMDC2 DDR2 ABTB2 SVEP1

1.21e-05195685ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCellRA-02._Fibroblast_II|RA / Chamber and Cluster_Paper

PTPRS MAMDC2 DDR2 ABTB2 SVEP1

1.21e-051956856a02ebbeb3199447ddce64d92d8809436e040eba
ToppCellfacs-Trachea-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPT CALU NTRK2 DDR2 SVEP1

1.21e-051956850d1876f6fdc1eafeb60d6fd7da5bce737d2b4a5a
ToppCell15-Trachea-Mesenchymal|Trachea / Age, Tissue, Lineage and Cell class

FKBP10 DPT NTRK2 DDR2 SVEP1

1.24e-051966857e178c76285e61c721c38d7a995ebf89dc428f9f
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPT PTPRS MAMDC2 DDR2 SVEP1

1.24e-051966859737a5f006d37b549f281e1863aca558e1e4dc99
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 DPT PTPRS MAMDC2 SVEP1

1.24e-0519668542e9828222a9663525d571633e8a454c30bfa7f8
ToppCellChildren_(3_yrs)-Mesenchymal|Children_(3_yrs) / Lineage, Cell type, age group and donor

FKBP10 PTPRS MAMDC2 DDR2 SVEP1

1.24e-05196685bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell15-Trachea-Mesenchymal-Mesenchyme_SERPINF1-high|Trachea / Age, Tissue, Lineage and Cell class

FKBP10 DPT NTRK2 DDR2 SVEP1

1.24e-0519668554aefcebf13704f51de84379e2e22ec0734b9461
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 DPT PTPRS MAMDC2 DDR2

1.24e-05196685d5ed41fa111750e6b363c04cccc40a47dd774852
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 DPT PTPRS MAMDC2 DDR2

1.24e-05196685760885dc608c82768fe0decd63ed9fda8315f453
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP1R9A EFCAB13 KCNJ16 HYDIN ABTB2

1.27e-051976857e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FKBP10 DPT PTPRS DDR2 SVEP1

1.27e-051976853bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FKBP10 DPT PTPRS DDR2 SVEP1

1.27e-0519768517344464fdcc5ba0c03959696b97c195f11e644c
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FKBP10 DPT PTPRS DDR2 SVEP1

1.27e-051976855b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

FKBP10 PTPRS MAMDC2 DDR2 SVEP1

1.31e-051986853ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCelltumor_Lung-Fibroblasts-COL13A1+_matrix_FBs|tumor_Lung / Location, Cell class and cell subclass

FKBP10 DPT MAMDC2 DDR2 SVEP1

1.31e-051986852d7842f352273b6b823c86eb548b9f4a4cddf0ae
ToppCelldistal-mesenchymal-Myofibroblast-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FKBP10 DPT MAMDC2 CPO P4HA3

1.31e-05198685beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

FKBP10 PTPRS MAMDC2 DDR2 SVEP1

1.31e-0519868526e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

FKBP10 PTPRS MAMDC2 DDR2 SVEP1

1.31e-05198685df3de77216f5c5d6141ec44d01c56b942f611838
ToppCelltumor_Lung-Fibroblasts-COL14A1+_matrix_FBs|tumor_Lung / Location, Cell class and cell subclass

FKBP10 DPT DDR2 P4HA3 SVEP1

1.31e-0519868574f2c7ef702b25a5b99e56121229e678ed992524
Drugamentoflavone

P4HA2 CALU GBE1 P4HA3

3.15e-0634684CID005281600
Diseaseazoospermia (implicated_via_orthology)

CDC42BPA PTPRS CDC42BPB

2.87e-0527653DOID:14227 (implicated_via_orthology)
Diseasecerebral cavernous malformation (implicated_via_orthology)

CDC42BPA CDC42BPB

2.59e-0411652DOID:0060669 (implicated_via_orthology)
Diseasehaptoglobin measurement

DHX38 HYDIN

9.77e-0421652EFO_0004640
DiseaseEpileptic encephalopathy

FGF12 ACTL6B

2.00e-0330652C0543888

Protein segments in the cluster

PeptideGeneStartEntry
TVHYEMPNGYNTDYG

ACTL6B

281

O94805
GSDELDSYMYQTVGH

DPH6

41

Q7L8W6
GFIDLEEYIGDMYSH

CALU

206

O43852
GHYGEEMDMISYNYD

DPT

151

Q07507
SLETYSYNIYHPMGE

CPO

41

Q8IVL8
YCEMLGYDASFGYIH

AP4E1

86

Q9UPM8
QHSQGTGAYYMETYL

RAVER2

671

Q9HCJ3
TAGEYIYIYGNMDED

TSPOAP1

681

O95153
QVGKVAYDMGDYYHA

P4HA3

186

Q7Z4N8
KSELGHYMYVDSVYV

MAMDC2

211

Q7Z304
HTTGVGYYMYIEASH

MAMDC2

546

Q7Z304
YLNDSVYDGAVGYSM

DDR2

211

Q16832
IHVIMYSYYGLTAFG

ELOVL4

191

Q9GZR5
MESDFYLRYYVGHKG

MAGOH

1

P61326
VSVYGTEEYLHPDMY

IKBKE

171

Q14164
NVGMNGYYIVHYEDD

ERAP1

601

Q9NZ08
ENHLYLVMDYYVGGD

CDC42BPB

146

Q9Y5S2
GSSYEYIEDMENLYH

MROH9

86

Q5TGP6
MESEDYHFYQGLVYL

HUWE1

4146

Q7Z6Z7
IMGSDYINANYVDGY

PTPRS

1441

Q13332
GMGRSAYNEGDYYHT

P4HA2

171

O15460
VYSGYYHLDQKSMTG

PRTG

936

Q2VWP7
STMHYAGGLFEEYSE

HFM1

631

A2PYH4
VYMRHAYGLGEHYNS

OTUD6B

266

Q8N6M0
VHELELYNTGYYLGM

CD109

611

Q6YHK3
FDYEQYEYHGTSSAM

CDC45

186

O75419
MEHAYYASFGYQITS

GBE1

241

Q04446
MGDFVRYHYNGTFED

FKBP10

61

Q96AY3
QYEETSIHMVGEGYE

HYDIN

3596

Q4G0P3
QGKRYYHGMEYETDL

GRHL3

86

Q8TE85
MGNDSVSYEYGDYSD

C5AR2

1

Q9P296
LEGQEYRMYNTYDVH

GBA2

526

Q9HCG7
HWYDVEGGMQDYNYV

CPD

326

O75976
YNLGHGLMEMAYNEY

ABCA2

1951

Q9BZC7
EHEEAMNAAYSGYVY

APBA1

156

Q02410
GSFYGHSIYATLYMD

CERS1

156

P27544
SNLYMTLYDEVTHGY

EFCAB13

151

Q8IY85
YLVMEYASGGEVFDY

MARK2

126

Q7KZI7
YAFEGSYLEDTQMYG

MEAF6

41

Q9HAF1
DSIHYQMVYSYGSGV

EMC1

171

Q8N766
EQTFMYYVNDGVYGS

ODC1

311

P11926
YVAMNGEGYLYSSDV

FGF12

126

P61328
YCLSGMYDHRYGDSE

HNRNPF

266

P52597
ASAHYMYRQEGYETV

HIC2

421

Q96JB3
MYRQEGYETVSYGDN

HIC2

426

Q96JB3
NGFYYDMYLEEGGVS

TARS1

181

P26639
YMDGRLIYSGSEENY

USH2A

2091

O75445
LMYSGAVFYTGVYDD

TAAR6

161

Q96RI8
LCHGYYDVMGQYDAT

SHISA7

81

A6NL88
YEYGVLNIHLTAYDM

MRPL48

86

Q96GC5
YDVHSLYGYSMAIAT

SI

556

P14410
IARGVHYQYGDMITY

SVEP1

3426

Q4LDE5
HYQYGDMITYSCYSG

SVEP1

3431

Q4LDE5
DDNNLYLVMDYYVGG

CDC42BPA

146

Q5VT25
ALQEAMYYSAEHGYV

ABTB2

716

Q8N961
EGVDSDYHDENMYYS

CNOT2

31

Q9NZN8
VYSTDYYRVGGHTML

NTRK2

701

Q16620
QVQGTYKYGYLTMDE

STIL

226

Q15468
YHSLMDEYGYEVGKA

TSSK4

16

Q6SA08
AYVGRGNSYMEYGHD

TTC6

246

Q86TZ1
MSYYGSSYHIINADA

KCNJ16

1

Q9NPI9
TQYLHEDGYTDYGMI

DHX38

566

Q92620
YEFDYHLYGQNVTMV

TOP3A

71

Q13472
MLEGHESYDTENFYF

ZNF841

1

Q6ZN19
HYVEGSYRDAISMYA

TTC7A

131

Q9ULT0
YGQVLYTDKTYAMGH

TNFSF13B

196

Q9Y275
VSLYGTEEYLHPDMY

TBK1

171

Q9UHD2
GYYGNLYLLVDHFME

TTI1

496

O43156
MEYTGSKYIGEYVDG

MORN5

1

Q5VZ52
DGSHVYMHSDYNVYR

PPP1R9A

391

Q9ULJ8
EETLDYGKNYNYGMH

NEUROD6

276

Q96NK8