Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cadmium ion binding	MT1F MT2A	2.18e-04	12	37	2	GO:0046870
GeneOntologyMolecularFunction	copper ion binding	MT1F MT1G MUC2	4.05e-04	78	37	3	GO:0005507
GeneOntologyMolecularFunction	zinc ion binding	KMT2A SETDB2 ZSWIM8 MT1F MT1G MT2A TES	1.10e-03	891	37	7	GO:0008270
GeneOntologyMolecularFunction	transition metal ion binding	KMT2A SETDB2 ZSWIM8 MT1F MT1G MT2A TES MUC2	1.27e-03	1189	37	8	GO:0046914
GeneOntologyBiologicalProcess	detoxification of copper ion	MT1F MT1G MT2A MUC2	1.40e-08	16	36	4	GO:0010273
GeneOntologyBiologicalProcess	stress response to copper ion	MT1F MT1G MT2A MUC2	1.40e-08	16	36	4	GO:1990169
GeneOntologyBiologicalProcess	stress response to metal ion	MT1F MT1G MT2A MUC2	5.59e-08	22	36	4	GO:0097501
GeneOntologyBiologicalProcess	detoxification of inorganic compound	MT1F MT1G MT2A MUC2	9.63e-08	25	36	4	GO:0061687
GeneOntologyBiologicalProcess	response to copper ion	MT1F MT1G MT2A MUC2	9.19e-07	43	36	4	GO:0046688
GeneOntologyBiologicalProcess	cellular response to copper ion	MT1F MT1G MT2A	1.39e-05	27	36	3	GO:0071280
GeneOntologyBiologicalProcess	cellular response to zinc ion	MT1F MT1G MT2A	1.55e-05	28	36	3	GO:0071294
GeneOntologyBiologicalProcess	nitric oxide mediated signal transduction	MT1F MT1G MT2A	4.61e-05	40	36	3	GO:0007263
GeneOntologyBiologicalProcess	cellular response to cadmium ion	MT1F MT1G MT2A	5.74e-05	43	36	3	GO:0071276
GeneOntologyBiologicalProcess	intracellular zinc ion homeostasis	MT1F MT1G MT2A	6.16e-05	44	36	3	GO:0006882
GeneOntologyBiologicalProcess	response to metal ion	KMT2A MT1F MT1G MT2A MUC2 ADAM9	7.47e-05	415	36	6	GO:0010038
GeneOntologyBiologicalProcess	cellular response to chromate	MT1F MT1G	8.24e-05	8	36	2	GO:0071247
GeneOntologyBiologicalProcess	response to chromate	MT1F MT1G	1.06e-04	9	36	2	GO:0046687
GeneOntologyBiologicalProcess	response to zinc ion	MT1F MT1G MT2A	1.64e-04	61	36	3	GO:0010043
GeneOntologyBiologicalProcess	detoxification	MT1F MT1G MT2A MUC2	2.14e-04	170	36	4	GO:0098754
GeneOntologyBiologicalProcess	response to cadmium ion	MT1F MT1G MT2A	2.26e-04	68	36	3	GO:0046686
GeneOntologyBiologicalProcess	positive regulation of integrin-mediated signaling pathway	PCSK5 LIMS2	2.66e-04	14	36	2	GO:2001046
GeneOntologyBiologicalProcess	monocyte activation	MT1G ADAM9	2.66e-04	14	36	2	GO:0042117
GeneOntologyBiologicalProcess	negative regulation of Wnt signaling pathway	TMEM131L IGFBP1 MDFI NLK	3.60e-04	195	36	4	GO:0030178
GeneOntologyBiologicalProcess	regulation of integrin-mediated signaling pathway	PCSK5 LIMS2	7.32e-04	23	36	2	GO:2001044
GeneOntologyBiologicalProcess	regulation of heterochromatin formation	KMT2A SETDB2	7.98e-04	24	36	2	GO:0031445
GeneOntologyCellularComponent	keratin filament	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	7.51e-07	97	37	5	GO:0045095
GeneOntologyCellularComponent	intermediate filament	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	4.74e-05	227	37	5	GO:0005882
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	9.52e-05	263	37	5	GO:0045111
MousePheno	big ears	KMT2A EDARADD	3.06e-05	5	25	2	MP:0000017
MousePheno	abnormal sternum morphology	PCSK5 KMT2A FRAS1 MDFI JADE2	7.65e-05	255	25	5	MP:0000157
MousePheno	abnormal tail position or orientation	KMT2A EDARADD	1.10e-04	9	25	2	MP:0013176
MousePheno	absent kidney	PCSK5 FRAS1 SLIT3	1.12e-04	53	25	3	MP:0000520
MousePheno	abnormal pectoral girdle bone morphology	PCSK5 KMT2A FRAS1 MDFI JADE2	1.67e-04	301	25	5	MP:0004508
Domain	KAP	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	9.78e-08	58	37	5	IPR002494
Domain	EGF-like_dom	PCSK5 CRELD2 FRAS1 ADAM28 ADAM9 SLIT3 OTOG	5.04e-07	249	37	7	IPR000742
Domain	Metalthion_vert_metal_BS	MT1F MT1G MT2A	8.51e-07	10	37	3	IPR018064
Domain	Keratin_B2_2	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-6	1.02e-06	39	37	4	PF13885
Domain	Keratin_B2	KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	1.13e-06	40	37	4	PF01500
Domain	Metalthion_dom_vert	MT1F MT1G MT2A	1.56e-06	12	37	3	IPR023587
Domain	Metalthion_dom	MT1F MT1G MT2A	1.56e-06	12	37	3	IPR017854
Domain	-	MT1F MT1G MT2A	1.56e-06	12	37	3	4.10.10.10
Domain	METALLOTHIONEIN_VRT	MT1F MT1G MT2A	2.02e-06	13	37	3	PS00203
Domain	Metalthion_vert	MT1F MT1G MT2A	2.57e-06	14	37	3	IPR000006
Domain	Metalthion	MT1F MT1G MT2A	2.57e-06	14	37	3	IPR003019
Domain	Metallothio	MT1F MT1G MT2A	2.57e-06	14	37	3	PF00131
Domain	Furin_repeat	PCSK5 CRELD2 FRAS1	5.72e-06	18	37	3	IPR006212
Domain	FU	PCSK5 CRELD2 FRAS1	5.72e-06	18	37	3	SM00261
Domain	EGF	PCSK5 CRELD2 FRAS1 ADAM28 ADAM9 SLIT3	6.24e-06	235	37	6	SM00181
Domain	VWC_out	FRAS1 MUC2 OTOG	6.79e-06	19	37	3	SM00215
Domain	CT	MUC2 SLIT3 OTOG	1.07e-05	22	37	3	SM00041
Domain	Growth_fac_rcpt_	PCSK5 CRELD2 FRAS1 IGFBP1 SLIT3	1.34e-05	156	37	5	IPR009030
Domain	Cys_knot_C	MUC2 SLIT3 OTOG	1.60e-05	25	37	3	IPR006207
Domain	CTCK_2	MUC2 SLIT3 OTOG	1.60e-05	25	37	3	PS01225
Domain	VWF_dom	FRAS1 MUC2 OTOG	7.79e-05	42	37	3	IPR001007
Domain	EGF_3	CRELD2 ADAM28 ADAM9 SLIT3 OTOG	9.48e-05	235	37	5	PS50026
Domain	TIL	MUC2 OTOG	2.49e-04	12	37	2	PF01826
Domain	C8	MUC2 OTOG	2.49e-04	12	37	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC2 OTOG	2.94e-04	13	37	2	IPR014853
Domain	C8	MUC2 OTOG	2.94e-04	13	37	2	SM00832
Domain	TIL_dom	MUC2 OTOG	3.42e-04	14	37	2	IPR002919
Domain	LIM	TES PDLIM5 LIMS2	3.43e-04	69	37	3	PF00412
Domain	-	TES PDLIM5 LIMS2	3.58e-04	70	37	3	2.10.110.10
Domain	LIM_DOMAIN_2	TES PDLIM5 LIMS2	3.73e-04	71	37	3	PS50023
Domain	Znf_LIM	TES PDLIM5 LIMS2	3.73e-04	71	37	3	IPR001781
Domain	LIM_DOMAIN_1	TES PDLIM5 LIMS2	3.73e-04	71	37	3	PS00478
Domain	LIM	TES PDLIM5 LIMS2	3.73e-04	71	37	3	SM00132
Domain	PHD	DPF1 KMT2A JADE2	4.38e-04	75	37	3	PF00628
Domain	VWFD	MUC2 OTOG	4.50e-04	16	37	2	PS51233
Domain	VWD	MUC2 OTOG	4.50e-04	16	37	2	SM00216
Domain	VWF_type-D	MUC2 OTOG	4.50e-04	16	37	2	IPR001846
Domain	VWD	MUC2 OTOG	4.50e-04	16	37	2	PF00094
Domain	Disintegrin_CS	ADAM28 ADAM9	4.50e-04	16	37	2	IPR018358
Domain	Znf_PHD-finger	DPF1 KMT2A JADE2	5.10e-04	79	37	3	IPR019787
Domain	CTCK_1	MUC2 SLIT3	5.73e-04	18	37	2	PS01185
Domain	ADAM_CR	ADAM28 ADAM9	5.73e-04	18	37	2	PF08516
Domain	-	ADAM28 ADAM9	7.09e-04	20	37	2	4.10.70.10
Domain	PHD	DPF1 KMT2A JADE2	7.23e-04	89	37	3	SM00249
Domain	Znf_PHD	DPF1 KMT2A JADE2	7.71e-04	91	37	3	IPR001965
Domain	DISIN	ADAM28 ADAM9	7.83e-04	21	37	2	SM00050
Domain	Disintegrin	ADAM28 ADAM9	7.83e-04	21	37	2	PF00200
Domain	EPHD	KMT2A JADE2	8.60e-04	22	37	2	PS51805
Domain	ZF_PHD_2	DPF1 KMT2A JADE2	8.74e-04	95	37	3	PS50016
Domain	ZF_PHD_1	DPF1 KMT2A JADE2	9.01e-04	96	37	3	PS01359
Domain	ADAM_Cys-rich	ADAM28 ADAM9	1.30e-03	27	37	2	IPR006586
Domain	ACR	ADAM28 ADAM9	1.30e-03	27	37	2	SM00608
Domain	EGF_1	CRELD2 ADAM28 ADAM9 SLIT3	1.57e-03	255	37	4	PS00022
Domain	EGF-like_CS	CRELD2 ADAM28 ADAM9 SLIT3	1.71e-03	261	37	4	IPR013032
Domain	EGF_2	CRELD2 ADAM28 ADAM9 SLIT3	1.81e-03	265	37	4	PS01186
Domain	VWFC_1	FRAS1 MUC2	2.31e-03	36	37	2	PS01208
Domain	VWC	FRAS1 MUC2	2.57e-03	38	37	2	SM00214
Domain	VWFC_2	FRAS1 MUC2	2.57e-03	38	37	2	PS50184
Domain	Peptidase_M12B_N	ADAM28 ADAM9	2.70e-03	39	37	2	IPR002870
Domain	Pep_M12B_propep	ADAM28 ADAM9	2.70e-03	39	37	2	PF01562
Domain	DISINTEGRIN_1	ADAM28 ADAM9	2.84e-03	40	37	2	PS00427
Domain	ADAM_MEPRO	ADAM28 ADAM9	2.84e-03	40	37	2	PS50215
Domain	DISINTEGRIN_2	ADAM28 ADAM9	2.84e-03	40	37	2	PS50214
Domain	Reprolysin	ADAM28 ADAM9	2.84e-03	40	37	2	PF01421
Domain	Peptidase_M12B	ADAM28 ADAM9	2.84e-03	40	37	2	IPR001590
Domain	SET	KMT2A SETDB2	2.98e-03	41	37	2	PF00856
Domain	Disintegrin_dom	ADAM28 ADAM9	2.98e-03	41	37	2	IPR001762
Domain	Znf_FYVE_PHD	DPF1 KMT2A JADE2	3.05e-03	147	37	3	IPR011011
Domain	SET	KMT2A SETDB2	3.74e-03	46	37	2	SM00317
Domain	SET_dom	KMT2A SETDB2	4.41e-03	50	37	2	IPR001214
Domain	SET	KMT2A SETDB2	4.41e-03	50	37	2	PS50280
Domain	MetalloPept_cat_dom	ADAM28 ADAM9	1.12e-02	81	37	2	IPR024079
Pathway	REACTOME_METALLOTHIONEINS_BIND_METALS	MT1F MT1G MT2A	1.42e-06	11	30	3	M27543
Pathway	REACTOME_RESPONSE_TO_METAL_IONS	MT1F MT1G MT2A	3.12e-06	14	30	3	M27541
Pathway	WP_COPPER_HOMEOSTASIS	MT1F MT1G MT2A ADAM9	4.54e-06	53	30	4	M39349
Pathway	REACTOME_KERATINIZATION	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	1.61e-05	153	30	5	MM15343
Pathway	WP_ZINC_HOMEOSTASIS	MT1F MT1G MT2A	6.44e-05	37	30	3	M39377
Pathway	REACTOME_KERATINIZATION	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	8.59e-05	217	30	5	M27640
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6 SLIT3	5.67e-04	502	30	6	MM14537
Pubmed	A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.	KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	2.18e-09	16	38	4	15028290
Pubmed	Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.	MT1F MT1G MT2A	1.20e-08	5	38	3	20812968
Pubmed	Metallothionein isogene transcription in red blood cell precursors from human cord blood.	MT1F MT1G MT2A	6.71e-08	8	38	3	11168427
Pubmed	Definitions and nomenclature of metallothioneins.	MT1F MT1G MT2A	1.01e-07	9	38	3	1779826
Pubmed	Diurnal regulation of sphingolipids in blood.	MT1F MT1G MT2A	1.01e-07	9	38	3	30557628
Pubmed	Metallothionein overexpression does not protect against inflammatory bowel disease in a murine colitis model.	MT1F MT1G MT2A	1.01e-07	9	38	3	15735556
Pubmed	Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral ischemia.	MT1F MT1G MT2A	1.01e-07	9	38	3	21913972
Pubmed	Cytoprotection by metallothionein against gastroduodenal mucosal injury caused by ethanol in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	10744072
Pubmed	Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis.	MT1F MT1G MT2A	1.01e-07	9	38	3	11585628
Pubmed	Epidermal proliferation of the skin in metallothionein-null mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	9506445
Pubmed	Interaction of dietary zinc and intracellular binding protein metallothionein in postnatal bone growth.	MT1F MT1G MT2A	1.01e-07	9	38	3	19254786
Pubmed	Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium.	MT1F MT1G MT2A	1.01e-07	9	38	3	10788577
Pubmed	Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity.	MT1F MT1G MT2A	1.01e-07	9	38	3	10966523
Pubmed	Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis.	MT1F MT1G MT2A	1.01e-07	9	38	3	12613667
Pubmed	Knockdown of metallothionein 1 and 2 does not affect atrophy or oxidant activity in a novel in vitro model.	MT1F MT1G MT2A	1.01e-07	9	38	3	20798270
Pubmed	Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.	MT1F MT1G MT2A	1.01e-07	9	38	3	8290567
Pubmed	Impaired hepatic regeneration in metallothionein-I/II knockout mice after partial hepatectomy.	MT1F MT1G MT2A	1.01e-07	9	38	3	15618127
Pubmed	Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals.	MT1F MT1G MT2A	1.01e-07	9	38	3	10828279
Pubmed	Induction of metallothionein synthesis by cilostazol in mice and in human cultured neuronal cell lines.	MT1F MT1G MT2A	1.01e-07	9	38	3	17409522
Pubmed	Gene expression profiles in the liver and kidney of metallothionein-null mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	15913548
Pubmed	Effect of Zn treatment on wild type and MT-null cell lines in relation to apoptotic and/or necrotic processes and on MT isoform gene expression.	MT1F MT1G MT2A	1.01e-07	9	38	3	16563532
Pubmed	Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation.	MT1F MT1G MT2A	1.01e-07	9	38	3	15520181
Pubmed	Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain.	MT1F MT1G MT2A	1.01e-07	9	38	3	12098501
Pubmed	Antioxidant status in the liver of hypertensive and metallothionein-deficient mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	14608409
Pubmed	Increased radiation-induced apoptosis in mouse thymus in the absence of metallothionein.	MT1F MT1G MT2A	1.01e-07	9	38	3	10413187
Pubmed	Early mouse preimplantation development is unaffected by microinjection of metallothionein antibodies.	MT1F MT1G MT2A	1.01e-07	9	38	3	7613878
Pubmed	Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	10099782
Pubmed	Metallothioneins 1 and 2 are expressed in the olfactory mucosa of mice in untreated animals and during the regeneration of the epithelial layer.	MT1F MT1G MT2A	1.01e-07	9	38	3	9125117
Pubmed	Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	24154695
Pubmed	A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells.	MT1F MT1G MT2A	1.01e-07	9	38	3	27610572
Pubmed	Metallothioneins regulate the adipogenic differentiation of 3T3-L1 cells via the insulin signaling pathway.	MT1F MT1G MT2A	1.01e-07	9	38	3	28426713
Pubmed	Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	10426817
Pubmed	Atrophy of large myelinated axons in metallothionein-I, II knockout mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	16133945
Pubmed	Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide.	MT1F MT1G MT2A	1.01e-07	9	38	3	15979673
Pubmed	Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons.	MT1F MT1G MT2A	1.01e-07	9	38	3	15306638
Pubmed	Analysis of the possible protective role of metallothionein in streptozotocin-induced diabetes using metallothionein-null mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	9176863
Pubmed	Metallothionein differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint.	MT1F MT1G MT2A	1.01e-07	9	38	3	26267326
Pubmed	Zinc treatment prevents lipopolysaccharide-induced teratogenicity in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	12854659
Pubmed	Metallothionein-1+2 protect the CNS after a focal brain injury.	MT1F MT1G MT2A	1.01e-07	9	38	3	11771944
Pubmed	Metallothionein deficiency leads to soleus muscle contractile dysfunction following acute spinal cord injury in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	19828842
Pubmed	Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	16936113
Pubmed	Decreased neurofilament density in large myelinated axons of metallothionein-I, II knockout mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	16600496
Pubmed	Quantitative immunogold study of increased expression of metallothionein-I/II in the brain perivascular areas of diabetic scrapie-infected mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	17031522
Pubmed	Metallothionein-null mice exhibit reduced tolerance to ultraviolet B injury in vivo.	MT1F MT1G MT2A	1.01e-07	9	38	3	14723724
Pubmed	Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	8615771
Pubmed	Mercury-induced cognitive impairment in metallothionein-1/2 null mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	18226494
Pubmed	Selective degeneration of central photoreceptors after hyperbaric oxygen in normal and metallothionein-knockout mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	18579766
Pubmed	Infection of metallothionein 1+2 knockout mice with Rocky Mountain Laboratory scrapie.	MT1F MT1G MT2A	1.01e-07	9	38	3	18221736
Pubmed	Metallothionein is a crucial protective factor against Helicobacter pylori-induced gastric erosive lesions in a mouse model.	MT1F MT1G MT2A	1.01e-07	9	38	3	18239062
Pubmed	Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53.	MT1F MT1G MT2A	1.01e-07	9	38	3	8619230
Pubmed	Distribution and retention of cadmium in metallothionein I and II null mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	8619234
Pubmed	Obesity and hyperleptinemia in metallothionein (-I and -II) null mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	9419380
Pubmed	Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival.	MT1F MT1G MT2A	1.01e-07	9	38	3	24138881
Pubmed	Susceptibility of metallothionein-null mice to the behavioral alterations caused by exposure to mercury vapor at human-relevant concentration.	MT1F MT1G MT2A	1.01e-07	9	38	3	15071173
Pubmed	The role of metallothionein in a dinitrofluorobenzene-induced atopic dermatitis-like murine model.	MT1F MT1G MT2A	1.01e-07	9	38	3	30042397
Pubmed	Metallothionein expression protects against carbon tetrachloride-induced hepatotoxicity, but overexpression and dietary zinc supplementation provide no further protection in metallothionein transgenic and knockout mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	11160536
Pubmed	Metallothionein-I/II double knockout mice are no more sensitive to the carcinogenic effects of nickel subsulfide than wild-type mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	16126615
Pubmed	Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia.	MT1F MT1G MT2A	1.01e-07	9	38	3	12122050
Pubmed	Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease.	MT1F MT1G MT2A	1.01e-07	9	38	3	22766972
Pubmed	The embryolethality of lipopolysaccharide in CD-1 and metallothionein I-II null mice: lack of a role for induced zinc deficiency or metallothionein induction.	MT1F MT1G MT2A	1.01e-07	9	38	3	12700403
Pubmed	Role of metallothionein in lung inflammation induced by ozone exposure in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	18929643
Pubmed	A mediator role for metallothionein in tumor necrosis factor-induced lethal shock.	MT1F MT1G MT2A	1.01e-07	9	38	3	11733576
Pubmed	Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure.	MT1F MT1G MT2A	1.01e-07	9	38	3	25485709
Pubmed	Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses.	MT1F MT1G MT2A	1.01e-07	9	38	3	16432836
Pubmed	Metallothioneins (I+II) and thyroid-thymus axis efficiency in old mice: role of corticosterone and zinc supply.	MT1F MT1G MT2A	1.01e-07	9	38	3	11850030
Pubmed	Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength.	MT1F MT1G MT2A	1.01e-07	9	38	3	27956698
Pubmed	Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways.	MT1F MT1G MT2A	1.01e-07	9	38	3	19837066
Pubmed	Cadmium modulates adipocyte functions in metallothionein-null mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	23921151
Pubmed	Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein.	MT1F MT1G MT2A	1.01e-07	9	38	3	11792622
Pubmed	Photoprotective role of metallothionein in UV-injury - metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B.	MT1F MT1G MT2A	1.01e-07	9	38	3	10764993
Pubmed	Development of a compartmental model of zinc kinetics in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	18936212
Pubmed	Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	10947810
Pubmed	Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6.	MT1F MT1G MT2A	1.01e-07	9	38	3	11950277
Pubmed	Metallothionein regulates intracellular zinc signaling during CD4(+) T cell activation.	MT1F MT1G MT2A	1.01e-07	9	38	3	27251638
Pubmed	Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity.	MT1F MT1G MT2A	1.01e-07	9	38	3	9512723
Pubmed	Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	23967274
Pubmed	Role of metallothionein in murine experimental colitis.	MT1F MT1G MT2A	1.01e-07	9	38	3	23467591
Pubmed	Cadmium-induced mRNA expression of Hsp32 is augmented in metallothionein-I and -II knock-out mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	11051100
Pubmed	STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart.	MT1F MT1G MT2A	1.01e-07	9	38	3	15639482
Pubmed	Role of metallothioneins as danger signals in the pathogenesis of colitis.	MT1F MT1G MT2A	1.01e-07	9	38	3	24452846
Pubmed	Role of metallothionein in coagulatory disturbance and systemic inflammation induced by lipopolysaccharide in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	16387980
Pubmed	Metallothionein-I/II null cardiomyocytes are sensitive to Fusarium mycotoxin butenolide-induced cytotoxicity and oxidative DNA damage.	MT1F MT1G MT2A	1.01e-07	9	38	3	20144643
Pubmed	Restriction fragment length variations and chromosome mapping of two mouse metallothionein genes, Mt-1 and Mt-2.	MT1F MT1G MT2A	1.01e-07	9	38	3	2576352
Pubmed	Protective effects of metallothionein against dopamine quinone-induced dopaminergic neurotoxicity.	MT1F MT1G MT2A	1.01e-07	9	38	3	17910954
Pubmed	The expression and significance of metallothioneins in murine organs and tissues following mercury vapour exposure.	MT1F MT1G MT2A	1.01e-07	9	38	3	14692620
Pubmed	Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner.	MT1F MT1G MT2A	1.01e-07	9	38	3	11298796
Pubmed	Nitric-oxide-mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone.	MT1F MT1G MT2A	1.01e-07	9	38	3	18483408
Pubmed	Development of high-fat-diet-induced obesity in female metallothionein-null mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	20219986
Pubmed	Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury.	MT1F MT1G MT2A	1.01e-07	9	38	3	23275622
Pubmed	Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction.	MT1F MT1G MT2A	1.01e-07	9	38	3	23880315
Pubmed	Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice.	MT1F MT1G MT2A	1.01e-07	9	38	3	11578143
Pubmed	Sensitivity of metallothionein-null mice to LPS/D-galactosamine-induced lethality.	MT1F MT1G MT2A	1.01e-07	9	38	3	11162523
Pubmed	Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury.	MT1F MT1G MT2A	1.01e-07	9	38	3	22363575
Pubmed	Alcohol-induced myocardial fibrosis in metallothionein-null mice: prevention by zinc supplementation.	MT1F MT1G MT2A	1.01e-07	9	38	3	16049321
Pubmed	Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.	MT1F MT1G MT2A	1.01e-07	9	38	3	10505629
Pubmed	Down-regulation of metallothionein 1 and 2 after exposure to electromagnetic field in mouse testis.	MT1F MT1G MT2A	1.01e-07	9	38	3	22395140
Pubmed	Regulation, linkage, and sequence of mouse metallothionein I and II genes.	MT1F MT1G MT2A	1.01e-07	9	38	3	6095054
Pubmed	Protective role of metallothionein in coagulatory disturbance accompanied by acute liver injury induced by LPS/D-GalN.	MT1F MT1G MT2A	1.01e-07	9	38	3	18449439
Pubmed	Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity.	MT1F MT1G MT2A	1.01e-07	9	38	3	26148447
Pubmed	Metallothionein gene expression and metal regulation during preimplantation mouse embryo development (MT mRNA during early development).	MT1F MT1G MT2A	1.01e-07	9	38	3	2019319
Interaction	HOXA1 interactions	PCSK5 CRELD2 ZNF843 MDFI KRTAP10-11 KRTAP10-4 SSUH2 LIMS2	1.72e-07	356	36	8	int:HOXA1
Interaction	LCE3C interactions	PCSK5 MDFI KRTAP10-11 KRTAP10-6	6.07e-06	67	36	4	int:LCE3C
Interaction	LCE1D interactions	PCSK5 MDFI KRTAP10-11 KRTAP10-6	7.23e-06	70	36	4	int:LCE1D
Interaction	LCE3D interactions	PCSK5 MDFI KRTAP10-11 KRTAP10-6	8.55e-06	73	36	4	int:LCE3D
Interaction	SPATA3 interactions	MDFI KRTAP10-11 KRTAP10-6	1.03e-05	24	36	3	int:SPATA3
Interaction	GPHA2 interactions	PCSK5 FRAS1 ADAM9	1.17e-05	25	36	3	int:GPHA2
Interaction	LCE1F interactions	PCSK5 MDFI KRTAP10-11 KRTAP10-6	2.14e-05	92	36	4	int:LCE1F
Interaction	KIAA0040 interactions	MDFI KRTAP10-6	4.63e-05	6	36	2	int:KIAA0040
Interaction	CFC1 interactions	PCSK5 CRELD2 FRAS1 ADAM9	7.35e-05	126	36	4	int:CFC1
Interaction	ZNF479 interactions	MDFI KRTAP10-6	8.63e-05	8	36	2	int:ZNF479
Interaction	ZNF679 interactions	MDFI KRTAP10-6	8.63e-05	8	36	2	int:ZNF679
Interaction	C22orf39 interactions	PCSK5 MDFI KRTAP10-11	9.11e-05	49	36	3	int:C22orf39
Interaction	ZNF221 interactions	MDFI KRTAP10-6	1.38e-04	10	36	2	int:ZNF221
Interaction	PRG2 interactions	PCSK5 CRELD2 ZSWIM8 FRAS1 ADAM9	1.44e-04	285	36	5	int:PRG2
Interaction	LYPD1 interactions	PCSK5 FRAS1 ADAM9	1.51e-04	58	36	3	int:LYPD1
Interaction	KRTAP10-1 interactions	ZNF664 KRTAP10-11 NLK KRTAP10-6	1.56e-04	153	36	4	int:KRTAP10-1
Interaction	OTX1 interactions	PCSK5 MDFI KRTAP10-11 KRTAP10-4	1.64e-04	155	36	4	int:OTX1
Interaction	LCE3E interactions	MDFI KRTAP10-11 KRTAP10-6	1.67e-04	60	36	3	int:LCE3E
Interaction	ZNF155 interactions	MDFI KRTAP10-6	1.69e-04	11	36	2	int:ZNF155
Interaction	LY6H interactions	PCSK5 ZNF664 ADAM9	1.75e-04	61	36	3	int:LY6H
Interaction	ZNF696 interactions	IGFBP1 MDFI KRTAP10-6	2.42e-04	68	36	3	int:ZNF696
Interaction	SHBG interactions	MT1F MT1G MT2A	2.53e-04	69	36	3	int:SHBG
Interaction	ADAMTSL3 interactions	MDFI KRTAP10-6	3.21e-04	15	36	2	int:ADAMTSL3
Interaction	IGFL3 interactions	PCSK5 FRAS1 ADAM9	3.24e-04	75	36	3	int:IGFL3
Interaction	ATN1 interactions	PCSK5 KMT2A ZSWIM8 MDFI	3.35e-04	187	36	4	int:ATN1
Interaction	LCE3A interactions	PCSK5 MDFI KRTAP10-11	3.36e-04	76	36	3	int:LCE3A
Interaction	LCE4A interactions	MDFI KRTAP10-11 KRTAP10-6	3.91e-04	80	36	3	int:LCE4A
Interaction	LCE2B interactions	MDFI KRTAP10-11 KRTAP10-6	4.06e-04	81	36	3	int:LCE2B
Interaction	ADAM2 interactions	ADAM28 ADAM9	4.15e-04	17	36	2	int:ADAM2
Interaction	LCE1A interactions	MDFI KRTAP10-11 KRTAP10-6	4.52e-04	84	36	3	int:LCE1A
Interaction	KRTAP5-9 interactions	PCSK5 KRTAP10-11 NLK KRTAP10-6	4.57e-04	203	36	4	int:KRTAP5-9
Interaction	LCE1B interactions	MDFI KRTAP10-11 KRTAP10-6	4.68e-04	85	36	3	int:LCE1B
Interaction	SIRPD interactions	CRELD2 FRAS1 ADAM9	4.84e-04	86	36	3	int:SIRPD
Interaction	ST14 interactions	PCSK5 CRELD2 ZNF664 ADAM9	4.92e-04	207	36	4	int:ST14
Interaction	ZNF138 interactions	MDFI KRTAP10-6	5.20e-04	19	36	2	int:ZNF138
Interaction	CCN6 interactions	CRELD2 FRAS1	5.20e-04	19	36	2	int:CCN6
Interaction	SPINK7 interactions	MT1G MT2A	5.20e-04	19	36	2	int:SPINK7
Interaction	MFSD3 interactions	MDFI KRTAP10-6	5.78e-04	20	36	2	int:MFSD3
Interaction	ZNF12 interactions	ZNF12 MDFI	5.78e-04	20	36	2	int:ZNF12
Interaction	LY86 interactions	PCSK5 CRELD2 TMEM131L ADAM9	5.88e-04	217	36	4	int:LY86
Interaction	KRTAP5-6 interactions	KRTAP10-11 NLK KRTAP10-6	6.28e-04	94	36	3	int:KRTAP5-6
Interaction	NKD1 interactions	MDFI KRTAP10-6	6.38e-04	21	36	2	int:NKD1
Interaction	ZPBP2 interactions	CRELD2 FRAS1	6.38e-04	21	36	2	int:ZPBP2
Interaction	GRIP1 interactions	FRAS1 TES GPR37	6.67e-04	96	36	3	int:GRIP1
Interaction	MOBP interactions	KRTAP10-11 KRTAP10-6	7.67e-04	23	36	2	int:MOBP
Interaction	RSPO2 interactions	KRTAP10-4 KRTAP10-6	8.35e-04	24	36	2	int:RSPO2
Cytoband	16q13	MT1F MT1G MT2A	3.67e-06	36	38	3	16q13
Cytoband	21q22.3	KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	3.95e-06	128	38	4	21q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16q13	MT1F MT1G MT2A	5.06e-06	40	38	3	chr16q13
Cytoband	Ensembl 112 genes in cytogenetic band chr21q22	KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	2.65e-04	377	38	4	chr21q22
GeneFamily	Keratin associated proteins	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	6.39e-07	109	28	5	619
GeneFamily	Metallothioneins	MT1F MT1G MT2A	3.17e-06	19	28	3	638
GeneFamily	PHD finger proteins	DPF1 KMT2A JADE2	3.57e-04	90	28	3	88
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM28 ADAM9	7.93e-04	27	28	2	47
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2A SETDB2	1.26e-03	34	28	2	487
GeneFamily	LIM domain containing	TES PDLIM5	3.75e-03	59	28	2	1218
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 ZNF12 ZNF843 ZNF664	2.37e-02	718	28	4	28
Coexpression	RICHERT_PBMC_HIV_LIPO_5_AGE_37_48YO_STIMULATED_VS_UNSTIMULATED_0W_14W_METALLOTHIONEIN_SUBSET_UP	MT1F MT1G MT2A	1.44e-07	8	37	3	M41082
Coexpression	NABA_ECM_GLYCOPROTEINS	CRELD2 FRAS1 IGFBP1 SLIT3 OTOG	7.03e-06	191	37	5	MM17059
Coexpression	IGLESIAS_E2F_TARGETS_DN	MT1F MT1G MT2A	7.40e-06	27	37	3	MM643
Coexpression	NABA_ECM_GLYCOPROTEINS	CRELD2 FRAS1 IGFBP1 SLIT3 OTOG	7.97e-06	196	37	5	M3008
Coexpression	NABA_MATRISOME	PCSK5 CRELD2 FRAS1 IGFBP1 MUC2 ADAM28 ADAM9 SLIT3 OTOG	8.36e-06	1008	37	9	MM17056
Coexpression	NABA_MATRISOME	PCSK5 CRELD2 FRAS1 IGFBP1 MUC2 ADAM28 ADAM9 SLIT3 OTOG	9.63e-06	1026	37	9	M5889
Coexpression	BUSSLINGER_DUODENAL_BCHE_CELLS	MT1F MT1G MT2A	3.07e-05	43	37	3	M40032
Coexpression	HOUSTIS_ROS	MT1F MT1G MT2A	3.30e-05	44	37	3	MM1142
Coexpression	NABA_CORE_MATRISOME	CRELD2 FRAS1 IGFBP1 SLIT3 OTOG	3.72e-05	270	37	5	MM17057
Coexpression	ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN	SETDB2 ZSWIM8 MT1F MT1G MT2A	3.99e-05	274	37	5	M13014
Coexpression	NABA_CORE_MATRISOME	CRELD2 FRAS1 IGFBP1 SLIT3 OTOG	4.06e-05	275	37	5	M5884
Coexpression	SCHLINGEMANN_SKIN_CARCINOGENESIS_TPA_UP	MT1F MT1G MT2A	4.29e-05	48	37	3	MM649
Coexpression	PIONTEK_PKD1_TARGETS_UP	MT1F MT1G MT2A	5.15e-05	51	37	3	MM794
Coexpression	BUSSLINGER_GASTRIC_CHIEF_CELLS	MT1F MT1G MT2A	6.82e-05	56	37	3	M40006
Coexpression	GUILLAUMOND_KLF10_TARGETS_UP	MT1F MT1G MT2A	7.97e-05	59	37	3	MM952
Coexpression	LEE_LIVER_CANCER_CIPROFIBRATE_UP	MT2A TES IGFBP1	8.38e-05	60	37	3	M2195
Coexpression	CSR_LATE_UP.V1_UP	MT1F MT1G MT2A PDLIM5	8.71e-05	166	37	4	M2660
Coexpression	LUDWICZEK_TREATING_IRON_OVERLOAD	MT1F MT2A	1.27e-04	12	37	2	MM792
Coexpression	DESCARTES_FETAL_SPLEEN_AFP_ALB_POSITIVE_CELLS	MT1F MT1G MT2A IGFBP1	1.41e-04	188	37	4	M40287
Coexpression	GSE25088_WT_VS_STAT6_KO_MACROPHAGE_ROSIGLITAZONE_AND_IL4_STIM_DN	MT1F MT1G MT2A SPATA2	1.65e-04	196	37	4	M8003
Coexpression	GSE3982_BCELL_VS_CENT_MEMORY_CD4_TCELL_DN	DPF1 ZNF12 KMT2A MT1F	1.72e-04	198	37	4	M5545
Coexpression	GSE22886_NAIVE_TCELL_VS_DC_UP	TMEM131L KMT2A TES JADE2	1.75e-04	199	37	4	M4475
Coexpression	GSE21546_WT_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_DN	TMEM131L KMT2A ADAM9 EDARADD	1.75e-04	199	37	4	M7522
Coexpression	GSE21927_SPLEEN_C57BL6_VS_4T1_TUMOR_BALBC_MONOCYTES_DN	MT1F MT1G MT2A JADE2	1.78e-04	200	37	4	M7595
Coexpression	GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN	IGFBP1 MDFI GPR37 ADAM28	1.78e-04	200	37	4	M9677
Coexpression	GSE360_L_MAJOR_VS_B_MALAYI_HIGH_DOSE_MAC_UP	PCSK5 MT1F MT1G MT2A	1.78e-04	200	37	4	M5247
Coexpression	ZHENG_RESPONSE_TO_ARSENITE_UP	MT1G MT2A	2.01e-04	15	37	2	M1589
Coexpression	BERENJENO_TRANSFORMED_BY_RHOA_REVERSIBLY_UP	MT1F MT2A	2.30e-04	16	37	2	MM1089
Coexpression	AIZARANI_LIVER_C14_HEPATOCYTES_2	MT1F MT1G MT2A IGFBP1	2.84e-04	226	37	4	M39118
Coexpression	BOYLAN_MULTIPLE_MYELOMA_PCA3_UP	MT1F MT1G MT2A	3.08e-04	93	37	3	MM850
Coexpression	FOSTER_TOLERANT_MACROPHAGE_DN	SETDB2 MT1F MT1G MT2A PDLIM5	3.46e-04	435	37	5	MM1221
Coexpression	ZHANG_UTERUS_C2_REGENERATIVE_UP	MT1F MT1G MT2A	3.48e-04	97	37	3	MM16605
Coexpression	DESCARTES_FETAL_STOMACH_MUC13_DMBT1_POSITIVE_CELLS	MT1F MT1G MT2A	3.48e-04	97	37	3	M40301
Coexpression	HUMMERICH_SKIN_CANCER_PROGRESSION_UP	MT1F MT1G MT2A	3.81e-04	100	37	3	MM514
Coexpression	VANDESLUIS_COMMD1_TARGETS_GROUP_2_UP	MT1F MT1G	4.40e-04	22	37	2	MM1299
Coexpression	SARTIPY_BLUNTED_BY_INSULIN_RESISTANCE_UP	MT1F MT2A	4.81e-04	23	37	2	MM1198
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	MT1F MT2A TES	5.31e-04	112	37	3	MM1095
Coexpression	MARKEY_RB1_ACUTE_LOF_DN	PCSK5 MT1F MT1G MT2A	5.34e-04	267	37	4	MM1091
Coexpression	MARTINEZ_RB1_TARGETS_UP	TMEM131L MT1F MT1G MT2A PDLIM5 NLK	5.50e-04	741	37	6	MM1037
Coexpression	HE_LIM_SUN_FETAL_LUNG_C3_HMOX1_POS_PRIMITIVE_ERYTHROBLAST	MT1F MT1G	5.70e-04	25	37	2	M45753
Coexpression	BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_UP	MT1F MT2A	5.70e-04	25	37	2	M15908
Coexpression	SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP	MT1F MT2A MDFI ADAM28 EDARADD	5.95e-04	490	37	5	MM1001
Coexpression	OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN	MT1F MT1G MT2A NLK	6.46e-04	281	37	4	M7089
Coexpression	DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN	ZNF12 FRAS1 GPR37 ADAM9 PDLIM5	6.76e-04	504	37	5	M2157
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2	MT1F MT2A TES EDARADD SLIT3	6.76e-04	504	37	5	MM830
Coexpression	KAN_RESPONSE_TO_ARSENIC_TRIOXIDE	MT1F MT1G MT2A	6.97e-04	123	37	3	M1784
Coexpression	TUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_UP	MT1F MT2A	7.16e-04	28	37	2	MM707
Coexpression	BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_UP	MT1F MT1G	7.16e-04	28	37	2	MM487
Coexpression	TABULA_MURIS_SENIS_HEART_AND_AORTA_CARDIOMYOCYTE_AGEING	MT1F MT1G MT2A	7.48e-04	126	37	3	MM3711
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_MESENCHYMAL_1_CELL	FRAS1 TES GPR37 LIMS2	7.65e-04	294	37	4	M45674
Coexpression	MA_RAT_AGING_UP	MT1F MT1G MT2A	7.65e-04	127	37	3	MM16096
Coexpression	IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP	MT1F MT1G MT2A	7.83e-04	128	37	3	M15887
Coexpression	PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP	CRELD2 MT1F MT1G MT2A	7.95e-04	297	37	4	MM1003
Coexpression	AIZARANI_LIVER_C11_HEPATOCYTES_1	MT1F MT1G MT2A IGFBP1	8.05e-04	298	37	4	M39115
Coexpression	SWEET_LUNG_CANCER_KRAS_UP	MT1F MT1G MT2A TES MDFI	8.76e-04	534	37	5	MM1050
Coexpression	PILON_KLF1_TARGETS_UP	KMT2A MT1F MT1G IGFBP1 NLK	9.29e-04	541	37	5	MM1061
Coexpression	TABULA_MURIS_SENIS_LIMB_MUSCLE_SKELETAL_MUSCLE_SATELLITE_CELL_AGEING	MT1F MT1G MT2A	9.33e-04	136	37	3	MM3747
Coexpression	TABULA_MURIS_SENIS_MAMMARY_GLAND_B_CELL_AGEING	CRELD2 MT1F MT1G MT2A	9.89e-04	315	37	4	MM3784
Coexpression	PECE_MAMMARY_STEM_CELL_UP	MT1F MT1G MT2A	9.94e-04	139	37	3	M2534
Coexpression	SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_DN	ZNF462 ZNF664	9.96e-04	33	37	2	M1359
Coexpression	RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN	MT1F MT1G MT2A ADAM28	1.05e-03	320	37	4	M8582
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	KRTAP29-1 KRTAP10-2 KRTAP10-11 KRTAP10-4 KRTAP10-6	1.55e-07	146	38	5	522c32103c24fc26836bb5b642083904682d9292
ToppCell	Parenchyma_COVID-19-Stromal-TX-Mesothelial-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	MT1F MT1G FRAS1 MT2A SLIT3	7.36e-07	200	38	5	bf50e30d5cafb71c567e89580f62084d2f894170
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MT1F MT1G FRAS1 MT2A SLIT3	7.36e-07	200	38	5	5e5ad07679d5dd2ca80249bce9aaf4a95d42187b
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	MT1F MT1G FRAS1 MT2A SLIT3	7.36e-07	200	38	5	c800f20adedf4ca736c740510889e92d8bf0ba44
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A SSUH2	1.25e-05	168	38	4	4e2e4c88ada772e9ba6e72c9ae3a05c063e93318
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A SSUH2	1.25e-05	168	38	4	ee4dab089adef2f47a9d39d91934523331a8b81c
ToppCell	367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	MT1G FRAS1 IGFBP1 GPR37	1.41e-05	173	38	4	e05cddf5bf63cf419343ff229453327519765be8
ToppCell	367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|367C / Donor, Lineage, Cell class and subclass (all cells)	MT1G FRAS1 IGFBP1 GPR37	1.41e-05	173	38	4	74ad5ed33821b8816c9c8e67c50ee4496ba18e2f
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PCSK5 PDLIM5 SSUH2 LIMS2	1.41e-05	173	38	4	3a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	1.44e-05	174	38	4	e7cca4b6a3935fad61cf2a3d9984ab1ffa1a9447
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	1.44e-05	174	38	4	ad5b56f0ace6455c033834b931ec870cc0dc9290
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	1.79e-05	184	38	4	886d2d9bf2fe31207f17e3edc309ef44029924e1
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	1.79e-05	184	38	4	936b39377eebea3961d702532779f6cd27953be7
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A PDLIM5	1.87e-05	186	38	4	41e03be964044dae690d566bd078dab3d8045eba
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A PDLIM5	1.91e-05	187	38	4	5c73010fe4c85fb5cc1273f5504821229ca0cc4b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A PDLIM5	1.91e-05	187	38	4	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A PDLIM5	1.91e-05	187	38	4	4d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A PDLIM5	1.91e-05	187	38	4	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A PDLIM5	1.91e-05	187	38	4	5d3d68519c8e19f10c29f9d81712125be78ca15a
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PCSK5 MT2A MDFI ADAM28	2.03e-05	190	38	4	71a00f63fdd4eb4cc6f190d37e7a0417cdaafacb
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A PDLIM5	2.12e-05	192	38	4	43beaac1de99b9c1a6dab4a450b4e81286987b64
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.16e-05	193	38	4	402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A PDLIM5	2.16e-05	193	38	4	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A PDLIM5	2.16e-05	193	38	4	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.16e-05	193	38	4	7ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell	5'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK5 MT1G MT2A MUC2	2.21e-05	194	38	4	2f6e62a4ec8707bd5a16c0734c5131af55207ea2
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.25e-05	195	38	4	e1fb987f13482d1fce0428413244be3621136424
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.25e-05	195	38	4	482a2e7db72f0da285bb658943dd668777519734
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.25e-05	195	38	4	09605533aa5947bb2e5a6725c1ce89f79d330bf5
ToppCell	5'-GW_trimst-2-LargeIntestine\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.25e-05	195	38	4	1a4a5623fa0318ef388cc228c7060e0586a7acf9
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.25e-05	195	38	4	7ff04c45a02df01e3816f3c1d43585a93182a730
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.30e-05	196	38	4	79bc7ab96b52b2a542348a13ddd0a4f095698c5e
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 MDFI ADAM28 EDARADD	2.34e-05	197	38	4	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	5'-Adult-SmallIntestine-Epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK5 MT1F MT1G MT2A	2.39e-05	198	38	4	8d629492d2199de8e036c19e9dacceb9c9e721a0
ToppCell	Healthy_Control-Myeloid-Macrophages-FCN1+SPP1+\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	MT1F MT1G MT2A PDLIM5	2.39e-05	198	38	4	aa90326b82e21de37af5642df6a70a8b21af7f04
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-goblet\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.39e-05	198	38	4	9c5d7852f03468394e726c444cac92a043fc6d0e
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.39e-05	198	38	4	f95f38cc747fb3549a791288bf8d0518c049ac96
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.44e-05	199	38	4	fb9550bbb1fa206c3132e0a21a646eedb41c281a
ToppCell	moderate-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MT1F MT1G MT2A ADAM9	2.44e-05	199	38	4	3895e367a33ac0316f96a64c07574de99684f4b7
ToppCell	5'-Adult-SmallIntestine\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK5 MT1F MT1G MT2A	2.44e-05	199	38	4	a5fffe381be1ba7d192b68d1d3937ce47663658e
ToppCell	3'-GW_trimst-1-SmallIntestine\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK5 MT1F MT1G MT2A	2.44e-05	199	38	4	c4a1e0cf3be867e7cebbd8bd3668bc2df391671b
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A MUC2	2.44e-05	199	38	4	440f47e320c75f49ef47139b46962de68cee8320
ToppCell	background\|World / Sample and Cell Type and Tumor Cluster (all cells)	MT1F MT1G MT2A IGFBP1	2.44e-05	199	38	4	5a6d0e00bfe1351eea192b54020bedeef78854e9
ToppCell	background-Hepatocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	MT1F MT1G MT2A IGFBP1	2.48e-05	200	38	4	423cca10df6ae0489a8fe7e7df87e70364dac022
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10---L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PCSK5 FRAS1 PDLIM5 LIMS2	2.48e-05	200	38	4	67ba7e5703842e38fa3508ac644461489043626f
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PCSK5 FRAS1 PDLIM5 LIMS2	2.48e-05	200	38	4	0248fe1eac23704687a2f11c6a3775bceae7a2b1
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PCSK5 FRAS1 PDLIM5 LIMS2	2.48e-05	200	38	4	f545ae8486bd72159247e055f0bb2796c254af61
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PCSK5 FRAS1 PDLIM5 LIMS2	2.48e-05	200	38	4	8acccefa60031541277fe6c1a7f58f7450961836
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_3\|Control_saline / Treatment groups by lineage, cell group, cell type	TMEM131L PDLIM5 SLIT3 LIMS2	2.48e-05	200	38	4	b0866b497aa71d06cef25f9a335fa584e95fa7e0
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	PCSK5 PDLIM5 SSUH2 LIMS2	2.48e-05	200	38	4	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Artery\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PCSK5 PDLIM5 SSUH2 LIMS2	2.48e-05	200	38	4	b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PCSK5 PDLIM5 SSUH2 LIMS2	2.48e-05	200	38	4	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	Control_saline-Endothelial-Endothelial-Artery\|Control_saline / Treatment groups by lineage, cell group, cell type	PCSK5 PDLIM5 SSUH2 LIMS2	2.48e-05	200	38	4	65b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PCSK5 PDLIM5 SSUH2 LIMS2	2.48e-05	200	38	4	ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCell	TCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma,_Immature_Teratoma,_Mature_Teratoma,_Yolk_Sac_Tumor-1\|TCGA-Testes / Sample_Type by Project: Shred V9	KRTAP10-2 KRTAP10-11 KRTAP10-6	6.84e-05	93	38	3	2a44d58ae88c05acb18adc959bc2f7cdcc1ac0b3
ToppCell	LV-03._Atrial_Cardiomyocyte\|LV / Chamber and Cluster_Paper	LINC02914 GPR37 PDLIM5	1.46e-04	120	38	3	3b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCell	LV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	LINC02914 GPR37 PDLIM5	1.85e-04	130	38	3	a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFDC13 FRAS1 ADAM28	2.35e-04	141	38	3	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFDC13 FRAS1 ADAM28	2.35e-04	141	38	3	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCell	facs-Heart-Unknown-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFDC13 FRAS1 ADAM28	2.39e-04	142	38	3	759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF462 MT1F JADE2	2.60e-04	146	38	3	159dd157a74f3c27dc1a1dcbbf0ed8f9462cac9e
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MT1F JADE2 EDARADD	3.10e-04	155	38	3	5687416773809b8c478567bc54310af102b3029a
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PCSK5 MT2A MDFI	3.21e-04	157	38	3	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PCSK5 EDARADD PDLIM5	3.46e-04	161	38	3	bf70be1de418615b5442ec684552551edaf1f072
ToppCell	wk_08-11-Hematologic-Meg-ery-HMOX1+_primitive_erythroblast\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MT1F MT1G MT2A	3.46e-04	161	38	3	6079de6cc4f2aec4091d0fac531fda9a441a70b1
ToppCell	3'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF462 MT1G ZNF843	3.52e-04	162	38	3	768a566e76923323c1f197f60bab472a8784490b
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DPF1 PDLIM5 SLIT3	3.59e-04	163	38	3	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DPF1 MDFI ADAM28	3.59e-04	163	38	3	f21951e63188eb0c04675a8f81a0da495c26c007
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Cajal-Retzius\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	GPR37 KRTAP10-2 KRTAP10-11	3.59e-04	163	38	3	c1484e4de8b10e2f5fb14a7c02b2a015ffe0305e
ToppCell	lung-Club_Cells\|lung / shred on tissue and cell subclass	MT2A MUC2 ADAM28	3.65e-04	164	38	3	b12cacd499b18b96120ca6d14646aebeaed41d10
ToppCell	wk_15-18-Hematologic-Meg-ery-HMOX1+_primitive_erythroblast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MT1F MT1G MT2A	3.72e-04	165	38	3	a040d18e4ba6da266440ad0b79990918770bfa7d
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FRAS1 ADAM28 EDARADD	3.92e-04	168	38	3	6521bead9789d626b86cbd08692c621c5a5aef33
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	3.99e-04	169	38	3	1dfaf9a6b433a5ee86a11962af188978c2543278
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	3.99e-04	169	38	3	3e267ec9f884df326315500dfd751b04a3dd91bd
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FRAS1 ADAM28 EDARADD	3.99e-04	169	38	3	c3ee781735a9288ce1822b230d39bb91c1415589
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	4.13e-04	171	38	3	f2b31c97bbcc5164fc279ed0362007878887ad5e
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	4.13e-04	171	38	3	3a2fefcb62e9d47ae6b3a946c45d3f2dd32c576c
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	4.13e-04	171	38	3	3ef44a5e3e8f81424f1e9aa302860b6688a549b8
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-Red_blood_cells-RBC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	4.13e-04	171	38	3	f21eae4dd2e0a566eff792d19367e96ffb0b74ba
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-Red_blood_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	4.13e-04	171	38	3	d428c2859a1efc284610ca241a6dae9f182309cd
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GPR37 SLIT3 LIMS2	4.13e-04	171	38	3	fdd96c6fe850bd10e1e0d0f18c4401f8348b7d2c
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A	4.20e-04	172	38	3	55fba5ce0ead1114e1a76f67ad68432c6bac90e5
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PCSK5 SSUH2 LIMS2	4.27e-04	173	38	3	b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCell	367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MT1G IGFBP1 GPR37	4.27e-04	173	38	3	3d7c281a1a9f183a5a861d1a9c7b50d216535893
ToppCell	367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MT1G IGFBP1 GPR37	4.27e-04	173	38	3	3aa90578371039f81b7c6fa873ec70f8f2bc7dfa
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	4.27e-04	173	38	3	81c36b9fe02c59099f080b2db02f4eaf2783911f
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	4.27e-04	173	38	3	021457c7bdb55de7351e43322d360e8fd7061658
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PCSK5 SSUH2 LIMS2	4.34e-04	174	38	3	18ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_MT-positive-Alveolar_macrophage_MT-positive_L.1.0.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MT1F MT1G MT2A	4.41e-04	175	38	3	b227d4499274fb63b193d34de7f2d812e283e79d
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_MT-positive\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MT1F MT1G MT2A	4.41e-04	175	38	3	308ee4ef7b9ecea68efca011ef91aed0f1be0eca
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK5 MT1F MT1G	4.41e-04	175	38	3	6759d200a133034756de9cdf2d5daceca927aac9
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK5 PDLIM5 LIMS2	4.49e-04	176	38	3	ed7ba2a3af3b060dec98b60f09f96000a67f7e63
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MT1F MT1G MT2A	4.49e-04	176	38	3	e7502a345b2da83a9a60f50cf78f1aef385c99df
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 SSUH2 LIMS2	4.49e-04	176	38	3	77516048aefbe1f48e825052756df0c310c1c486
ToppCell	wk_15-18-Hematologic-Meg-ery-Primitive_erythrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MT1F MT1G MT2A	4.49e-04	176	38	3	664a7d15563428d0ae156d97aa88415fd0a0506a
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 SSUH2 LIMS2	4.49e-04	176	38	3	96779273b94345250cf53ba671203345b43d9e00
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_FOS\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A	4.56e-04	177	38	3	191c14e0ef162536028b841f3759aaddef59b49d
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PCSK5 SSUH2 LIMS2	4.56e-04	177	38	3	5ff8dcfb030312126695d53a026d2e104a401b83
ToppCell	ASK440-Epithelial-Transformed_epithelium\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	MT1G MT2A SLIT3	4.64e-04	178	38	3	86f1741636ed3e85bb4a65f84949b718fc38c290
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MT1F MT1G MT2A	4.64e-04	178	38	3	4813d6509738f088c12ebf395b70d496af04649a
Computational	Genes upregulated in subsets of cells of a given type within various tumors	MT1F MT1G MT2A	2.03e-04	50	25	3	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_METAL_RESPONSE
Drug	MeOBGDTC	MT1F MT1G MT2A	6.46e-07	11	37	3	CID000119173
Drug	AC1L45V9	MT1F MT1G MT2A IGFBP1	8.38e-07	45	37	4	CID000151205
Drug	alpha-mercapto-beta-(2-furyl)acrylic acid	MT1F MT1G MT2A	1.12e-06	13	37	3	CID006437871
Drug	diamsar	MT1F MT1G MT2A	1.42e-06	14	37	3	CID000146286
Drug	Cadmium-thionein	MT1F MT1G MT2A	1.42e-06	14	37	3	CID000198548
Drug	MT45	MT1F MT1G MT2A	1.77e-06	15	37	3	CID000431865
Drug	urs-12-ene-3beta,28-diol	MT1F MT1G MT2A	1.77e-06	15	37	3	CID000092802
Drug	ZnATP	MT1F MT1G MT2A	2.64e-06	17	37	3	CID006455240
Drug	tolmetin glucuronide	MT1F MT1G MT2A	2.64e-06	17	37	3	ctd:C056583
Drug	bismuth nitrate	MT1F MT1G MT2A	2.64e-06	17	37	3	CID000107711
Drug	azelaic bishydroxamic acid	MT1F MT1G MT2A	2.64e-06	17	37	3	CID000065268
Drug	Disperse Blue 7	MT1F MT1G MT2A IGFBP1	2.88e-06	61	37	4	CID000018514
Drug	zomepirac glucuronide	MT1F MT1G MT2A	3.17e-06	18	37	3	ctd:C027368
Drug	AC1O3QMZ	MT1F MT1G MT2A	3.76e-06	19	37	3	CID006334573
Drug	cadmium oxide	MT1F MT1G MT2A	5.15e-06	21	37	3	CID000014782
Drug	4-(2-pyridylazo)resorcinol	MT1F MT1G MT2A	5.96e-06	22	37	3	CID005370169
Drug	zinc hydroxide	MT1F MT1G MT2A	5.96e-06	22	37	3	CID000062742
Drug	manganese sulfate monohydrate	MT1F MT1G MT2A	6.84e-06	23	37	3	CID000166832
Drug	thapsigargin; Up 200; 0.1uM; MCF7; HT_HG-U133A	CRELD2 ZSWIM8 MT1F MT1G TES	7.86e-06	170	37	5	7053_UP
Drug	hinokitiol	MT1F MT1G MT2A	8.87e-06	25	37	3	CID000003611
Drug	MT20	MT1F MT1G MT2A	1.00e-05	26	37	3	CID003025942
Drug	BGDTC	MT1F MT1G MT2A	1.00e-05	26	37	3	CID000105107
Drug	Oral-Turinabol	MT1F MT1G MT2A	1.12e-05	27	37	3	CID000098521
Drug	Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; HL60; HG-U133A	ZSWIM8 MT1F MT1G MT2A PDLIM5	1.49e-05	194	37	5	1364_UP
Drug	Fluorometholone [426-13-1]; Up 200; 10.6uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A MDFI NLK	1.53e-05	195	37	5	6247_UP
Drug	Betulinic acid [472-15-1]; Up 200; 8.8uM; MCF7; HT_HG-U133A	DPF1 KMT2A MT1F MT1G MT2A	1.60e-05	197	37	5	4181_UP
Drug	Dicumarol [66-76-2]; Up 200; 11.8uM; PC3; HT_HG-U133A	DPF1 ZSWIM8 IGFBP1 JADE2 SLIT3	1.64e-05	198	37	5	3766_UP
Drug	Propantheline bromide [50-34-0]; Up 200; 9uM; HL60; HT_HG-U133A	ZSWIM8 MDFI ADAM28 SLIT3 LIMS2	1.68e-05	199	37	5	3013_UP
Drug	Tolbutamide [64-77-7]; Up 200; 14.8uM; MCF7; HT_HG-U133A	KMT2A ZSWIM8 MDFI GPR37 PDLIM5	1.68e-05	199	37	5	2320_UP
Drug	Ormaplatino	MT1F MT1G MT2A	1.72e-05	31	37	3	CID006434704
Drug	alpha-hederin	MT1F MT1G MT2A	1.90e-05	32	37	3	CID000073296
Drug	CdCl2	MT1F MT1G MT2A NLK	1.91e-05	98	37	4	CID000024947
Drug	Zinquin	MT1F MT1G MT2A	2.08e-05	33	37	3	CID000132933
Drug	rhodanine	MT1F MT1G MT2A	2.28e-05	34	37	3	CID001201546
Drug	bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)	KMT2A MT1F MT1G MT2A	2.42e-05	104	37	4	ctd:C551172
Drug	p-hydroxyphenyllactic acid	MT1F MT1G MT2A	2.72e-05	36	37	3	CID000009378
Drug	genistin	MT1F MT1G MT2A	3.20e-05	38	37	3	CID005281377
Drug	arsenic(III	MT1F MT1G MT2A	3.74e-05	40	37	3	CID000104734
Drug	bismuth	MT1F MT1G MT2A	4.34e-05	42	37	3	CID000105143
Drug	trans-DDP	MT1F MT1G MT2A	5.00e-05	44	37	3	CID000084691
Drug	trien	MT1F MT1G MT2A	5.71e-05	46	37	3	CID000005565
Drug	midodrine	MT1F MT1G MT2A	6.10e-05	47	37	3	CID000004195
Drug	octachloronaphthalene	MT1F MT1G MT2A	6.10e-05	47	37	3	CID000016692
Drug	DL-propargylglycine	MT1F MT1G MT2A	6.50e-05	48	37	3	CID000095575
Drug	dimercaprol	MT1F MT1G MT2A	6.50e-05	48	37	3	CID000003080
Drug	auranofin	MT1F MT1G MT2A	8.26e-05	52	37	3	CID006918453
Drug	dimethylmercury	MT1F MT1G MT2A	8.26e-05	52	37	3	CID000011645
Drug	oleanolic acid	MT1F MT1G MT2A	8.26e-05	52	37	3	CID000010494
Drug	dicarboxymethyldithiocarbamate	MT1F MT2A	9.18e-05	9	37	2	CID000130472
Drug	CAPSO-DTC	MT1F MT2A	9.18e-05	9	37	2	CID003081023
Drug	vanadium	MT1F MT1G MT2A NLK	9.83e-05	149	37	4	CID000023990
Drug	PmMT	MT1F MT2A	1.15e-04	10	37	2	CID000085248
Drug	2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine	MT1F MT2A	1.15e-04	10	37	2	CID000819992
Drug	Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A TES	1.20e-04	157	37	4	2651_UP
Drug	tetrathiomolybdate	MT1F MT1G MT2A	1.33e-04	61	37	3	CID005245480
Drug	CAP-N-DTC	MT1F MT2A	1.40e-04	11	37	2	CID000125337
Drug	Fendiline hydrochloride [13636-18-5]; Up 200; 11.4uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A TES	1.42e-04	164	37	4	7188_UP
Drug	ZnSO4.7H2O	MT1F MT1G MT2A	1.47e-04	63	37	3	CID000062639
Drug	5224221; Up 200; 12uM; MCF7; HT_HG-U133A_EA	MT1F MT1G MT2A TES	1.49e-04	166	37	4	956_UP
Drug	Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A	TMEM131L MT1F MT1G MT2A	1.60e-04	169	37	4	7441_UP
Drug	Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A TES	1.63e-04	170	37	4	5021_UP
Drug	Hexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A	MT1F MT1G FRAS1 MT2A	1.67e-04	171	37	4	3318_UP
Drug	Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A TES	1.75e-04	173	37	4	6451_UP
Drug	Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A TES	1.79e-04	174	37	4	5613_UP
Drug	zinc sulfate	MT1F MT1G MT2A	1.92e-04	69	37	3	CID000024424
Drug	L-beta-aspartyl phosphate	MT1F MT1G MT2A	1.92e-04	69	37	3	CID000000832
Drug	Disulfiram [97-77-8]; Up 200; 13.4uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A TES	1.99e-04	179	37	4	6210_UP
Drug	5224221; Up 200; 12uM; MCF7; HT_HG-U133A_EA	MT1F MT1G MT2A TES	1.99e-04	179	37	4	839_UP
Drug	Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; HL60; HT_HG-U133A	MT1F MT1G MT2A PDLIM5	2.04e-04	180	37	4	2410_UP
Drug	Organoselenium Compounds	MT1F MT1G MT2A	2.09e-04	71	37	3	ctd:D016566
Drug	Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; PC3; HG-U133A	CRELD2 SPATA2 GPR37 PDLIM5	2.12e-04	182	37	4	1905_UP
Drug	Alexidine dihydrochloride [22573-93-9]; Up 200; 6.8uM; HL60; HT_HG-U133A	MT1F MT1G MT2A TES	2.12e-04	182	37	4	2576_UP
Drug	Raloxifene hydrochloride [82640-04-8]; Up 200; 7.8uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A PDLIM5	2.17e-04	183	37	4	3480_UP
Drug	ursolic acid	MT1F MT1G MT2A	2.18e-04	72	37	3	CID000064945
Drug	fluoroacetic acid	MT1F MT1G MT2A	2.18e-04	72	37	3	CID000005236
Drug	Fe-NTA	MT1F MT1G MT2A	2.27e-04	73	37	3	CID000027880
Drug	Disulfiram	CRELD2 MT1F MT1G MT2A ADAM9 PDLIM5 SLIT3	2.35e-04	785	37	7	ctd:D004221
Drug	Hexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A TES	2.35e-04	187	37	4	5420_UP
Drug	Clioquinol [130-26-7]; Up 200; 13uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A ADAM28	2.35e-04	187	37	4	5258_UP
Drug	Estradiol-17 beta [50-28-2]; Up 200; 14.6uM; HL60; HT_HG-U133A	MT1F MT1G MT2A ADAM28	2.40e-04	188	37	4	1299_UP
Drug	tyrphostin AG-825; Up 200; 25.2uM; MCF7; HT_HG-U133A_EA	CRELD2 MT1F MT1G MT2A	2.50e-04	190	37	4	1114_UP
Drug	Chlorhexidine [55-56-1]; Up 200; 8uM; MCF7; HT_HG-U133A	ZSWIM8 MT1F MT1G MT2A	2.60e-04	192	37	4	1525_UP
Drug	Ethynylestradiol 3-methyl ether [72-33-3]; Up 200; 12.8uM; PC3; HT_HG-U133A	ZSWIM8 MT1F IGFBP1 PDLIM5	2.66e-04	193	37	4	4208_UP
Drug	Dexamethasone acetate [1177-87-3]; Up 200; 9.2uM; PC3; HT_HG-U133A	MT1F MT1G MT2A JADE2	2.66e-04	193	37	4	2079_UP
Drug	Verteporfin [129497-78-5]; Up 200; 2.8uM; MCF7; HT_HG-U133A	MT1F FRAS1 MT2A TES	2.71e-04	194	37	4	3556_UP
Drug	mercuric bromide	MT1F MT1G MT2A TES GPR37 ADAM28 ADAM9 SLIT3	2.75e-04	1076	37	8	ctd:C042720
Drug	Chlorhexidine [55-56-1]; Up 200; 8uM; HL60; HG-U133A	MT1F MT1G MT2A TES	2.76e-04	195	37	4	2025_UP
Drug	beta-hydroxy simvastatin acid	MT1F MT1G MT2A	2.76e-04	78	37	3	ctd:C483161
Drug	fludrocortisone acetate; Up 200; 1uM; MCF7; HG-U133A	KMT2A MUC2 JADE2 SLIT3	2.87e-04	197	37	4	282_UP
Drug	Ticlopidine hydrochloride [53885-35-1]; Down 200; 13.4uM; HL60; HG-U133A	KMT2A ZSWIM8 TES SPATA2	2.87e-04	197	37	4	1975_DN
Drug	copper(II) sulfate pentahydrate; Up 200; 100uM; MCF7; HG-U133A	MT1F MT2A PDLIM5 SLIT3	2.87e-04	197	37	4	438_UP
Drug	Betulin [473-98-3]; Up 200; 9uM; MCF7; HT_HG-U133A	MT1F MT1G MT2A PDLIM5	2.87e-04	197	37	4	7454_UP
Drug	Nitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; HL60; HT_HG-U133A	KMT2A MT1F MT1G ADAM28	2.87e-04	197	37	4	2188_UP
Drug	Cinnarizine [298-57-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	TMEM131L ZSWIM8 SPATA2 GPR37	2.93e-04	198	37	4	7174_DN
Drug	Nifurtimox [23256-30-6]; Down 200; 14uM; PC3; HT_HG-U133A	KMT2A MT1F GPR37 PDLIM5	2.93e-04	198	37	4	6608_DN
Drug	copper(II) sulfate pentahydrate; Down 200; 100uM; MCF7; HG-U133A	SPATA2 MUC2 PDLIM5 SLIT3	2.93e-04	198	37	4	575_DN
Drug	Indapamide [26807-65-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A	DPF1 ZSWIM8 MDFI MUC2	2.93e-04	198	37	4	3970_UP
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HG-U133A	MT1F TES SLIT3 LIMS2	2.93e-04	198	37	4	121_DN
Drug	selenium	MT1F MT1G MT2A	2.98e-04	80	37	3	CID006326970
Drug	Torsemide [56211-40-6]; Down 200; 11.4uM; PC3; HT_HG-U133A	KMT2A MUC2 GPR37 LIMS2	2.98e-04	199	37	4	5057_DN
Disease	Alzheimer's disease (biomarker_via_orthology)	MT1F MT2A ADAM9	4.51e-05	58	35	3	DOID:10652 (biomarker_via_orthology)
Disease	retinitis pigmentosa (biomarker_via_orthology)	MT1F MT2A	1.06e-04	13	35	2	DOID:10584 (biomarker_via_orthology)
Disease	median neuropathy (biomarker_via_orthology)	MT1F MT2A	1.23e-04	14	35	2	DOID:571 (biomarker_via_orthology)
Disease	kidney failure (biomarker_via_orthology)	MT1F MT2A	2.31e-04	19	35	2	DOID:1074 (biomarker_via_orthology)
Disease	sleep duration, high density lipoprotein cholesterol measurement	MT1F MT1G ZNF664	4.00e-04	121	35	3	EFO_0004612, EFO_0005271
Disease	Prostatic Neoplasms	KMT2A MT2A JADE2 ADAM28 ADAM9	7.54e-04	616	35	5	C0033578
Disease	Malignant neoplasm of prostate	KMT2A MT2A JADE2 ADAM28 ADAM9	7.54e-04	616	35	5	C0376358
Disease	sexual dimorphism measurement	ZNF462 PCSK5 MT2A ZNF664 ADAM28 SLIT3	1.75e-03	1106	35	6	EFO_0021796
Disease	QT interval	TMEM131L FRAS1 JADE2 PDLIM5	3.56e-03	534	35	4	EFO_0004682
Disease	ankylosing spondylitis	PCSK5 ADAM28	5.24e-03	91	35	2	EFO_0003898

Protein segments in the cluster

Peptide	Gene	Start	Entry
CDCGTSEECTNICCD	ADAM28	421	Q9UKQ2
QCIECKSCSLCGTSE	DPF1	321	Q92782
STNTCKECDWSCSAC	FRAS1	951	Q86XX4
WCVSCFSCSTCNSKL	LIMS2	276	Q7Z4I7
CSLCKECTGTCIQCS	JADE2	311	Q9NQC1
SCKTCNGSATLCTSC	PCSK5	1186	Q92824
ASCSEVTRSAGCGCC	IGFBP1	46	P08833
ADTCCNITVCKCNTS	MUC2	4876	Q02817
DTCFVCSVCCESLEG	PDLIM5	561	Q96HC4
TCMCKCCFSTSTGRV	NLK	436	Q9UBE8
SCAAGDSCTCAGSCK	MT2A	6	P02795
CCCEECIQKSSTVTS	GPR37	566	O15354
CCEGSTCKLKSFAEC	ADAM9	441	Q13443
CATCGSCSSEDSCLC	MDFI	186	Q99750
SKDNSCKENCTCSSC	EDARADD	91	Q8WWZ3
ICTKCVRCKSCGSTT	KMT2A	1526	Q03164
CKAVCCVPTCSESSS	KRTAP10-2	146	P60368
TVCCKPVCSEDSSSC	KRTAP10-4	236	P60372
ACCTASCCRSSSSVS	KRTAP10-6	291	P60371
CCKPVCCVSTCSEDS	KRTAP10-11	151	P60412
CCVSTCSEDSSSCCQ	KRTAP10-11	156	P60412
SESTCCQEKCCDASP	KRTAP29-1	111	A8MX34
CTACDESCKTCSGLT	CRELD2	196	Q6UXH1
SCAAGVSCTCAGSCK	MT1F	6	P04733
TKARCCGECSTCFCT	LINC02914	61	Q52M58
CGECSTCFCTEEKSE	LINC02914	66	Q52M58
CTCTSGKWECSTAVC	OTOG	496	Q6ZRI0
TECFLCSCCSKCLIG	TES	386	Q9UGI8
CVDKFCSDSSSDCGS	TMEM131L	1296	A2VDJ0
CSTCSGRGNKTCATC	SSUH2	226	Q9Y2M2
TKCTCSAASVDCHGL	SLIT3	36	O75094
DSCDCSEGCIDITKC	SETDB2	291	Q96T68
SKCQSCGLSCSSSLC	SPATA2	381	Q9UM82
TCTQCSKVSCDACLS	SPATA2	471	Q9UM82
SCAAAGVSCTCASSC	MT1G	6	P13640
CRVTSCSCTCGAGAK	ZSWIM8	181	A7E2V4
CCGCGKAFSQSSSLC	ZNF664	201	Q8N3J9
CCCSCGDSVNEKTSL	ZNF843	146	Q8N446
RCDKCTFTCSSDESL	ZNF462	2301	Q96JM2
CEKECTGVNSCISCD	ZBED9	606	Q6R2W3
CSECGKCFCRKSTLT	ZNF12	411	P17014
CCSSFCGIVCSSETF	WFDC13	61	Q8IUB5