Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessviral transcription

TRIM27 REST

3.45e-0458102GO:0019083
GeneOntologyBiologicalProcessviral gene expression

TRIM27 REST

1.21e-03109102GO:0019080
GeneOntologyBiologicalProcessRNA splicing

REST RBM48 FRA10AC1

1.51e-03502103GO:0008380
GeneOntologyBiologicalProcessmRNA processing

REST RBM48 FRA10AC1

1.98e-03551103GO:0006397
Domain-

U2SURP RBM48

7.14e-032441023.30.70.330
DomainNucleotide-bd_a/b_plait

U2SURP RBM48

7.95e-03258102IPR012677
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

PDE3A TRIM27 FLG2

3.48e-0523410336243803
Pubmed

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.

U2SURP FLG2

1.58e-046610236095012
Pubmed

Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma.

TRIM27 FLG2

1.63e-046710229863498
Cytoband1q21.3

KCNN3 FLG2

2.86e-041171021q21.3
CytobandEnsembl 112 genes in cytogenetic band chr1q21

KCNN3 FLG2

3.32e-03404102chr1q21
GeneFamilyRNA binding motif containing

U2SURP RBM48

3.69e-0321382725
ToppCellLPS-IL1RA-Unknown-Endothelial-Monocytes-Macrophages|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE3A RBM48

5.76e-041631026b11a3ada8725670d0489f404c8c2175ad3904e9
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A KCNN3

6.26e-04170102833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PDE3A KCNN3

6.94e-041791021ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE3A KCNN3

7.48e-041861022d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3A KCNN3

7.73e-0418910212b6f1c3bf526b90e112374bf937701f645c5780
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE3A KCNN3

7.73e-04189102b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE3A KCNN3

7.73e-04189102c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3A KCNN3

7.81e-04190102bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

PDE3A KCNN3

7.81e-041901021519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE3A KCNN3

7.81e-04190102aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE3A KCNN3

7.89e-041911024b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE3A KCNN3

7.97e-0419210220ede290e01ad574afd122d72b59dbc52c595fad
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE3A KCNN3

8.05e-0419310296c85b250d04b5f400512097d925061c6dc2906b
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE3A KCNN3

8.05e-041931027cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3A KCNN3

8.05e-041931020b328f725f6feba263783eaca60c142e80df90f3
ToppCellfacs-Lung-nan-3m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A KCNN3

8.22e-041951027f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE3A KCNN3

8.30e-04196102308fa54385ca34e9e590967d4553b84aad96c92f
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial-Astroglia|6_mon / Sample Type, Dataset, Time_group, and Cell type.

KCNN3 REST

8.39e-041971023f088eb29197bc575400d6dafd8083e69e4a149f
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG|World / Primary Cells by Cluster

KCNN3 REST

8.39e-0419710261749ccafeb938c310cff1de5ff924a1c794325a
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A KCNN3

8.39e-041971025bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial|6_mon / Sample Type, Dataset, Time_group, and Cell type.

KCNN3 REST

8.39e-04197102965d5a3f8c9b12cb8a8d3429702ae29ebd8c6122
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG-25|World / Primary Cells by Cluster

KCNN3 REST

8.39e-041971029d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCellNon-neuronal-Dividing-Radial_Glia-vRG-20|World / Primary Cells by Cluster

KCNN3 REST

8.47e-04198102bce0bc1e3f2257e0f42a1fa6e5b57cf71e4514ba
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE3A KCNN3

8.47e-0419810212cd9f0bbad8dce5199ebfed1c4a8080710ca055
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

U2SURP REST

8.56e-04199102c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

U2SURP REST

8.56e-04199102fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PDE3A KCNN3

8.64e-04200102b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

KCNN3 REST

8.64e-04200102792fef1f3e47ce5c131fedfad55075fc254aeead
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

PDE3A KCNN3

8.64e-0420010265b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
DrugTRAM-34

KCNN3 REST

1.55e-0443102CID000656734
DrugIron, Dietary

TRIM27 SLC31A1

1.78e-0446102ctd:D019266
DrugMP-B

PDE3A ARFGAP2

5.94e-0484102CID000016827
DrugDB08184

TRIM27 REST

2.32e-03167102CID009547945
Drugsilver nanoparticles

REST ARFGAP2

2.45e-03172102CID000023954
Drug17-AAG; Down 200; 1uM; PC3; HT_HG-U133A

U2SURP REST

2.80e-031841024430_DN
Drugfullerene C60

SLC31A1 U2SURP KCNN3 REST

2.84e-031498104ctd:C069837
DrugMianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; MCF7; HT_HG-U133A

U2SURP REST

2.95e-031891022231_UP
DrugNaproxen [22204-53-1]; Down 200; 17.4uM; MCF7; HT_HG-U133A

REST RBM48

3.01e-031911021706_DN
DrugGuanfacine hydrochloride [29110-48-3]; Down 200; 14.2uM; MCF7; HT_HG-U133A

REST RBM48

3.01e-031911022634_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A_EA

RBM48 ARFGAP2

3.04e-031921021047_DN
DrugScopolamine hydrochloride [55-16-3]; Down 200; 11.8uM; PC3; HT_HG-U133A

U2SURP REST

3.11e-031941024219_DN
Druggenistein; Up 200; 10uM; MCF7; HT_HG-U133A_EA

REST RBM48

3.11e-031941021073_UP
DrugMenadione [58-27-5]; Down 200; 23.2uM; PC3; HT_HG-U133A

U2SURP REST

3.11e-031941024662_DN
DrugICI 182,780; Down 200; 1uM; PC3; HT_HG-U133A

U2SURP REST

3.11e-031941024429_DN
DrugNeomycin sulfate [1405-10-3]; Down 200; 4.2uM; MCF7; HT_HG-U133A

U2SURP REST

3.11e-031941027221_DN
Diseaseage-related macular degeneration

KCNN3 REST

3.98e-0489102EFO_0001365
DiseaseFEV/FEC ratio

PDE3A U2SURP KCNN3 REST

5.12e-041228104EFO_0004713
Diseasesexual dimorphism measurement

TRIM27 REST RBM48

5.17e-031106103EFO_0021796

Protein segments in the cluster

PeptideGeneStartEntry
SSSDLFGDMDGAHGA

ARFGAP2

461

Q8N6H7
MASSGGELGSLFDHH

RBM48

1

Q5RL73
DNMSEGSDDSGLHGA

REST

1021

Q13127
GSGHSESSDSEVHSG

FLG2

1421

Q5D862
MHGHGGYDSDFSDDE

FRA10AC1

1

Q70Z53
MDTSGHFHDSGVGDL

KCNN3

1

Q9UGI6
SDSDSDSGFTHGHMG

PDE3A

786

Q14432
TTSASHSHGGGDSSM

SLC31A1

26

O15431
DGFSGHVGNHGHSME

TRIM27

496

P14373
VHSSGSSDAHMDASG

U2SURP

21

O15042