Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	HSR	SP140L SP140	1.32e-05	5	22	2	PF03172
Domain	HSR	SP140L SP140	1.32e-05	5	22	2	PS51414
Domain	HSR_dom	SP140L SP140	1.32e-05	5	22	2	IPR004865
Domain	SAND_dom	SP140L SP140	3.69e-05	8	22	2	IPR000770
Domain	SAND	SP140L SP140	3.69e-05	8	22	2	PS50864
Domain	SAND	SP140L SP140	3.69e-05	8	22	2	PF01342
Domain	SAND	SP140L SP140	3.69e-05	8	22	2	SM00258
Domain	Zinc_finger_PHD-type_CS	SP140L NFXL1 SP140	5.91e-05	65	22	3	IPR019786
Domain	-	SP140L SP140	8.68e-05	12	22	2	3.10.390.10
Domain	SAND_dom-like	SP140L SP140	8.68e-05	12	22	2	IPR010919
Domain	Bromodomain	SP140L SP140	9.08e-04	38	22	2	PF00439
Domain	BROMODOMAIN_2	SP140L SP140	1.06e-03	41	22	2	PS50014
Domain	BROMO	SP140L SP140	1.11e-03	42	22	2	SM00297
Domain	Bromodomain	SP140L SP140	1.11e-03	42	22	2	IPR001487
Domain	-	SP140L SP140	1.11e-03	42	22	2	1.20.920.10
Domain	Sushi	CFH F13B	1.69e-03	52	22	2	PF00084
Domain	CCP	CFH F13B	1.83e-03	54	22	2	SM00032
Domain	SUSHI	CFH F13B	1.96e-03	56	22	2	PS50923
Domain	Sushi_SCR_CCP_dom	CFH F13B	2.03e-03	57	22	2	IPR000436
Domain	PHD	SP140L SP140	3.49e-03	75	22	2	PF00628
Domain	Znf_PHD-finger	SP140L SP140	3.86e-03	79	22	2	IPR019787
Domain	PHD	SP140L SP140	4.87e-03	89	22	2	SM00249
Domain	Znf_PHD	SP140L SP140	5.09e-03	91	22	2	IPR001965
Domain	ZF_PHD_2	SP140L SP140	5.53e-03	95	22	2	PS50016
Domain	ZF_PHD_1	SP140L SP140	5.65e-03	96	22	2	PS01359
Domain	Znf_FYVE_PHD	SP140L SP140	1.28e-02	147	22	2	IPR011011
Domain	Znf_RING/FYVE/PHD	RNF17 SP140L SP140	1.60e-02	459	22	3	IPR013083
Pubmed	Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.	SP140L SP140	3.82e-07	2	22	2	36130593
Pubmed	Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.	SP140L SP140	3.82e-07	2	22	2	35952671
Pubmed	The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice.	SP140L SP140	3.82e-07	2	22	2	34156030
Pubmed	Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.	CASP3 NEUROD6 NEFL	5.01e-07	25	22	3	19373938
Pubmed	Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse.	CASP3 DLX5	1.15e-06	3	22	2	31900962
Pubmed	Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury.	CASP3 NEFL	1.15e-06	3	22	2	19619516
Pubmed	Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons.	SP140L SP140	2.29e-06	4	22	2	34151776
Pubmed	Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.	CASP3 NEFL	3.82e-06	5	22	2	18687884
Pubmed	Sip1 downstream Effector ninein controls neocortical axonal growth, ipsilateral branching, and microtubule growth and stability.	CASP3 NEUROD6	3.82e-06	5	22	2	25741725
Pubmed	Molecular cloning of the b subunit of mouse coagulation factor XIII and assignment of the gene to chromosome 1: close evolutionary relationship to complement factor H.	CFH F13B	3.82e-06	5	22	2	8468048
Pubmed	The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development.	CASP3 DLX5	5.72e-06	6	22	2	28982687
Pubmed	The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.	CFH F13B	5.72e-06	6	22	2	18541031
Pubmed	Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture.	CASP3 NEUROD6	8.01e-06	7	22	2	23791179
Pubmed	Deregulated Rac1 Activity in Neural Crest Controls Cell Proliferation, Migration and Differentiation During Midbrain Development.	CASP3 NEFL	8.01e-06	7	22	2	34557485
Pubmed	Nestin is required for the proper self-renewal of neural stem cells.	CASP3 NEFL	1.07e-05	8	22	2	20963821
Pubmed	Cohesin-dependence of neuronal gene expression relates to chromatin loop length.	CASP3 NEUROD6	1.07e-05	8	22	2	35471149
Pubmed	MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling.	CASP3 NEUROD6	1.37e-05	9	22	2	25224226
Pubmed	Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis.	SP140L SP140	1.37e-05	9	22	2	38029747
Pubmed	Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.	CFH CASP3	1.37e-05	9	22	2	20299368
Pubmed	Ephrin-B2 paces neuronal production in the developing neocortex.	CASP3 NEUROD6	1.71e-05	10	22	2	32404061
Pubmed	Twist2: role in corneal stromal keratocyte proliferation and corneal thickness.	CASP3 NEFL	1.71e-05	10	22	2	20574024
Pubmed	Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development.	CASP3 DLX5	2.09e-05	11	22	2	28769044
Pubmed	Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.	CASP3 NEUROD6	2.09e-05	11	22	2	33087478
Pubmed	Oxidative stress regulates progenitor behavior and cortical neurogenesis.	CASP3 NEUROD6	2.09e-05	11	22	2	32041791
Pubmed	Molecular mechanisms underlying inner ear patterning defects in kreisler mutants.	NEFL DLX5	2.51e-05	12	22	2	16325169
Pubmed	Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.	CASP3 DLX5	2.97e-05	13	22	2	30905259
Pubmed	The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum.	CASP3 DLX5	3.46e-05	14	22	2	21048141
Pubmed	Neural crest cell-derived VEGF promotes embryonic jaw extension.	CASP3 DLX5	3.46e-05	14	22	2	25922531
Pubmed	Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice.	CASP3 NEUROD6	3.99e-05	15	22	2	24781987
Pubmed	Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells.	CASP3 DLX5	3.99e-05	15	22	2	17074316
Pubmed	C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development.	NEUROD6 NEFL	3.99e-05	15	22	2	27111087
Pubmed	Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme.	CASP3 DLX5	3.99e-05	15	22	2	33483579
Pubmed	Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.	CASP3 NEUROD6	3.99e-05	15	22	2	25002511
Pubmed	MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation.	NEUROD6 NEFL	3.99e-05	15	22	2	29546593
Pubmed	Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.	CASP3 NEUROD6	3.99e-05	15	22	2	22810622
Pubmed	An Early Cortical Progenitor-Specific Mechanism Regulates Thalamocortical Innervation.	CASP3 NEUROD6	4.56e-05	16	22	2	34193558
Pubmed	VPS35 deficiency in the embryonic cortex leads to prenatal cell loss and abnormal development of axonal connectivity.	CASP3 NEUROD6	4.56e-05	16	22	2	35367368
Pubmed	Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.	CASP3 DLX5	4.56e-05	16	22	2	24650709
Pubmed	Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling.	CASP3 DLX5	4.56e-05	16	22	2	21362415
Pubmed	Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.	CASP3 NEFL	4.56e-05	16	22	2	32321712
Pubmed	Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis.	CASP3 DLX5	4.56e-05	16	22	2	19476657
Pubmed	Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling.	NEFL DLX5	4.56e-05	16	22	2	15829521
Pubmed	Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy.	CASP3 DLX5	4.56e-05	16	22	2	16007083
Pubmed	Role of BRCA1 in brain development.	CASP3 DLX5	4.56e-05	16	22	2	24639535
Pubmed	Sox2 is required for olfactory pit formation and olfactory neurogenesis through BMP restriction and Hes5 upregulation.	CASP3 DLX5	4.56e-05	16	22	2	29352015
Pubmed	Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death.	CASP3 NEFL	4.56e-05	16	22	2	17116257
Pubmed	A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis.	CASP3 NEUROD6	5.16e-05	17	22	2	30201687
Pubmed	Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation.	CASP3 DLX5	5.16e-05	17	22	2	25626636
Pubmed	mTOR regulates brain morphogenesis by mediating GSK3 signaling.	CASP3 NEUROD6	5.16e-05	17	22	2	25273085
Pubmed	GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.	CASP3 NEUROD6	5.81e-05	18	22	2	25073924
Pubmed	Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.	CASP3 NEUROD6	5.81e-05	18	22	2	27618312
Pubmed	Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.	CASP3 NEUROD6	5.81e-05	18	22	2	35762573
Pubmed	Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling.	CASP3 DLX5	5.81e-05	18	22	2	18634775
Pubmed	Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity.	CASP3 NEUROD6	5.81e-05	18	22	2	35930666
Pubmed	Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons.	CASP3 NEFL	5.81e-05	18	22	2	26302206
Pubmed	The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development.	CASP3 NEUROD6	5.81e-05	18	22	2	28939666
Pubmed	p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration.	CASP3 DLX5	5.81e-05	18	22	2	23022035
Pubmed	Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity.	CASP3 NEUROD6	5.81e-05	18	22	2	27307230
Pubmed	Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium.	CASP3 DLX5	6.49e-05	19	22	2	32985705
Pubmed	Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear.	CASP3 DLX5	6.49e-05	19	22	2	19913004
Pubmed	RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion.	CASP3 NEUROD6	6.49e-05	19	22	2	22095278
Pubmed	Twist1 contributes to cranial bone initiation and dermal condensation by maintaining Wnt signaling responsiveness.	CASP3 DLX5	6.49e-05	19	22	2	26677825
Pubmed	SP8 regulates signaling centers during craniofacial development.	CASP3 DLX5	6.49e-05	19	22	2	23872235
Pubmed	Neurogenin 2 has an essential role in development of the dentate gyrus.	CASP3 NEUROD6	6.49e-05	19	22	2	18448566
Pubmed	Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development.	CASP3 DLX5	6.49e-05	19	22	2	21831920
Pubmed	Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala.	NEUROD6 DLX5	6.49e-05	19	22	2	33492553
Pubmed	Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex.	CASP3 NEUROD6	7.21e-05	20	22	2	26848828
Pubmed	Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode.	CASP3 DLX5	7.21e-05	20	22	2	18495817
Pubmed	Msx1 and Msx2 in limb mesenchyme modulate digit number and identity.	CASP3 DLX5	7.21e-05	20	22	2	21465616
Pubmed	The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons.	CASP3 DLX5	7.21e-05	20	22	2	15173589
Pubmed	Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.	CASP3 DLX5	7.21e-05	20	22	2	25535916
Pubmed	Sox9 is required for invagination of the otic placode in mice.	CASP3 DLX5	7.21e-05	20	22	2	18377888
Pubmed	Rap1 GTPases Are Master Regulators of Neural Cell Polarity in the Developing Neocortex.	NEUROD6 NEFL	8.76e-05	22	22	2	26733533
Pubmed	Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c.	CASP3 NEUROD6	8.76e-05	22	22	2	26182416
Pubmed	Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex.	NEUROD6 DLX5	8.76e-05	22	22	2	19820705
Pubmed	Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.	CASP3 DLX5	8.76e-05	22	22	2	19020049
Pubmed	Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.	CASP3 NEFL	8.76e-05	22	22	2	26711500
Pubmed	AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning.	CASP3 DLX5	8.76e-05	22	22	2	29229773
Pubmed	An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.	CASP3 NEUROD6	8.76e-05	22	22	2	37540708
Pubmed	Hedgehog signaling patterns the oral-aboral axis of the mandibular arch.	CASP3 DLX5	8.76e-05	22	22	2	30638444
Pubmed	Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.	CASP3 NEUROD6	8.76e-05	22	22	2	32049024
Pubmed	Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis.	CASP3 DLX5	9.59e-05	23	22	2	23112163
Pubmed	Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway.	CASP3 DLX5	9.59e-05	23	22	2	32616504
Pubmed	Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.	CASP3 DLX5	9.59e-05	23	22	2	28289129
Pubmed	Serum response factor is required for cortical axon growth but is dispensable for neurogenesis and neocortical lamination.	CASP3 NEUROD6	9.59e-05	23	22	2	22090492
Pubmed	The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.	CASP3 DLX5	1.05e-04	24	22	2	26550799
Pubmed	Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria.	CASP3 DLX5	1.05e-04	24	22	2	29852132
Pubmed	The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing.	CASP3 DLX5	1.14e-04	25	22	2	17679093
Pubmed	Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.	CASP3 NEUROD6	1.14e-04	25	22	2	28288114
Pubmed	Wnt signals mediate a fate decision between otic placode and epidermis.	CASP3 DLX5	1.14e-04	25	22	2	16452098
Pubmed	Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.	CASP3 NEUROD6	1.14e-04	25	22	2	29311744
Pubmed	Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.	CASP3 NEUROD6	1.14e-04	25	22	2	32737294
Pubmed	PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia.	NEUROD6 NEFL	1.23e-04	26	22	2	29899142
Pubmed	Redundant functions of Rac GTPases in inner ear morphogenesis.	CASP3 DLX5	1.23e-04	26	22	2	22182523
Pubmed	A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.	CASP3 NEUROD6	1.23e-04	26	22	2	26651292
Pubmed	Spatiotemporal structure of cell fate decisions in murine neural crest.	DLX5 SGPP2	1.23e-04	26	22	2	31171666
Pubmed	Endothelial cells regulate neural crest and second heart field morphogenesis.	CASP3 DLX5	1.23e-04	26	22	2	24996922
Pubmed	Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.	CASP3 NEUROD6	1.33e-04	27	22	2	37995181
Pubmed	Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors.	CASP3 NEUROD6	1.33e-04	27	22	2	30692224
Pubmed	An integrative method for scoring candidate genes from association studies: application to warfarin dosing.	ABHD16A F13B	1.33e-04	27	22	2	21044367
Cytoband	2q37.1	SP140L SP140	4.76e-04	67	22	2	2q37.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFH F13B	5.96e-04	75	22	2	chr1q31
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	SP140L SP140	5.22e-03	226	22	2	chr2q37
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH F13B	1.61e-03	57	19	2	1179
GeneFamily	PHD finger proteins	SP140L SP140	3.97e-03	90	19	2	88
Coexpression	TABULA_MURIS_SENIS_LUNG_NON_CLASSICAL_MONOCYTE_AGEING	CFH SP140L SP140	9.22e-06	49	22	3	MM3772
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	AP1M2 NEUROD6 NEFL	2.81e-05	121	22	3	05c40fd39e6b6275f35aaad835f95a81fcbb0990
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	NEUROD6 NEFL SGPP2	5.03e-05	147	22	3	8f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell	356C-Epithelial_cells-Epithelial-C_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	RNF17 AP1M2 SGPP2	6.59e-05	161	22	3	78cb72c462167021195917a06052bcdc367ad890
ToppCell	356C-Epithelial_cells-Epithelial-C_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	RNF17 AP1M2 SGPP2	6.59e-05	161	22	3	06e7becfd11d6ef1a45a9cfdfcb40b812600038e
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	AP1M2 NEUROD6 NEFL	6.83e-05	163	22	3	218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH SMPDL3A DLX5	7.61e-05	169	22	3	c6750c45c44be68aea39e918ba97c6f875ccea34
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH SMPDL3A DLX5	7.61e-05	169	22	3	15d5758d94a14a909d1d0c8bba9ce497a33d1512
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	CFH PLEKHM3 DLX5	8.29e-05	174	22	3	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	BAL-Control-cDC_1\|Control / Compartment, Disease Groups and Clusters	RNF17 SP140L SP140	8.72e-05	177	22	3	aa021f6d62e9d740c5ea499faaf875de835a2865
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMPDL3A ADIPOR2 DLX5	9.17e-05	180	22	3	cc31d2cd06161300b91b17a67bb432b75f0d719b
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMPDL3A ADIPOR2 DLX5	9.47e-05	182	22	3	94d061b7b5ebbfc564c644bc8b2d52341927145d
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-PNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	NEUROD6 NEFL FRMD4B	1.20e-04	197	22	3	10e72b425a2bcba35e63a5b074d3dedcd49a762e
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SMPDL3A FRMD4B DLX5	1.20e-04	197	22	3	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SMPDL3A FRMD4B DLX5	1.20e-04	197	22	3	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer\|World / Primary Cells by Cluster	NEUROD6 NEFL FRMD4B	1.25e-04	200	22	3	db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21\|World / Primary Cells by Cluster	NEUROD6 NEFL FRMD4B	1.25e-04	200	22	3	30a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon\|organoid_Velasco_nature / Sample Type, Dataset, Time_group, and Cell type.	NEUROD6 NEFL FRMD4B	1.25e-04	200	22	3	f6d6a2f4e2f51c292dfb97280353a49117798fc6
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital\|World / Primary Cells by Cluster	NEUROD6 NEFL FRMD4B	1.25e-04	200	22	3	6bbe8e1f3e91678f1bfb14945365c1578a59a604
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital-19\|World / Primary Cells by Cluster	NEUROD6 NEFL FRMD4B	1.25e-04	200	22	3	c831d9e0a7178e3634da45548f91fa9e8dc6557c
Drug	safrole oxide	CASP3 NEFL	4.43e-05	11	21	2	CID000101123
Drug	diphenylditelluride	CASP3 NEFL	5.32e-05	12	21	2	ctd:C434247
Drug	Phenylmethylsulfonyl Fluoride	CASP3 NEFL	8.45e-05	15	21	2	ctd:D010664
Drug	calpeptin	CASP3 NEFL	9.65e-05	16	21	2	ctd:C071482
Drug	tri-o-cresyl phosphate	CASP3 NEFL	9.65e-05	16	21	2	ctd:C025541
Drug	6-Cyano-7-nitroquinoxaline-2,3-dione	CASP3 NEFL	9.65e-05	16	21	2	ctd:D018750
Drug	8-((4-chlorophenyl)thio)cyclic-3',5'-AMP	CASP3 FRMD4B	9.65e-05	16	21	2	ctd:C015929
Drug	panobinostat	SP140L CASP3 AP1M2 NEFL SMPDL3A PLEKHM3 SGPP2	1.30e-04	1333	21	7	ctd:C496932
Drug	AC1L1ICD	CASP3 NEFL	2.03e-04	23	21	2	CID000004516
Drug	trimethyltin chloride	CASP3 NEFL	2.60e-04	26	21	2	ctd:C040533
Drug	dihydrosphingosine	CASP3 SMPDL3A SGPP2	3.16e-04	146	21	3	CID000003126
Drug	Carbon Disulfide	CASP3 NEFL	3.71e-04	31	21	2	ctd:D002246
Drug	Linoleic Acids, Conjugated	CASP3 ADIPOR2	4.20e-04	33	21	2	ctd:D044243
Drug	staurosporine aglycone	CASP3 FRMD4B	4.20e-04	33	21	2	ctd:C049985
Drug	maltolate	CASP3 NEFL	4.73e-04	35	21	2	CID000092427
Drug	Factor Xiiib	CFH F13B	4.73e-04	35	21	2	CID000126166
Drug	AC1O5KXC	CFH CASP3	5.29e-04	37	21	2	CID006436011
Drug	aluminum lactate	CASP3 NEFL	5.58e-04	38	21	2	ctd:C104223
Drug	Trenbolone Acetate	CFH CASP3	5.58e-04	38	21	2	ctd:D014204
Drug	ferric ammonium citrate	CASP3 MRPS9	5.88e-04	39	21	2	ctd:C013531
Drug	Dantrolene	CASP3 NEFL	6.50e-04	41	21	2	ctd:D003620
Drug	Ketamine	CASP3 NEUROD6 NEFL ABHD16A DLX5	6.66e-04	798	21	5	ctd:D007649
Drug	Pentolinium bitartrate [52-62-0]; Down 200; 7.4uM; PC3; HT_HG-U133A	SP140L AP1M2 SMPDL3A	7.13e-04	193	21	3	7375_DN
Drug	Pheniramine maleate [132-20-7]; Up 200; 11.2uM; PC3; HT_HG-U133A	CFH TPTE DLX5	7.56e-04	197	21	3	4012_UP
Drug	Sulmazole [73384-60-8]; Up 200; 14uM; PC3; HT_HG-U133A	RNF17 TPTE DLX5	7.56e-04	197	21	3	4009_UP
Drug	Cisapride [81098-60-4]; Up 200; 8.6uM; PC3; HT_HG-U133A	CFH FRMD4B DLX5	7.68e-04	198	21	3	6706_UP
Drug	Methacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; PC3; HT_HG-U133A	NEUROD6 FRMD4B SP140	7.68e-04	198	21	3	4062_UP
Drug	Dorzolamide hydrochloride [130693-82-2]; Up 200; 11uM; MCF7; HT_HG-U133A	RNF17 FRMD4B DLX5	7.79e-04	199	21	3	3565_UP
Drug	KN 93	CASP3 NEFL	8.18e-04	46	21	2	ctd:C072105
Drug	AC1L1BKI	TPTE F13B	8.18e-04	46	21	2	CID000001478
Disease	complement factor H-related protein 2 measurement	CFH F13B	1.94e-04	29	21	2	EFO_0600055
Disease	complement factor H-related protein 5 measurement	CFH F13B	4.08e-04	42	21	2	EFO_0008098
Disease	complement factor H-related protein 4 measurement	CFH SGPP2	5.56e-04	49	21	2	EFO_0600091

Protein segments in the cluster

Peptide	Gene	Start	Entry
YSFLYKTIEVFCEYF	AP1M2	81	Q9Y6Q5
PYYSYCQLETIFSIY	CATSPERD	696	Q86XM0
SYYSSPFAFFYLYRK	ABHD16A	71	O95870
KYYSYYCDEHFETPS	CFH	351	P08603
ADFLYAYSTAPGYYS	CASP3	191	P42574
SYPAKAYADYSYASS	DLX5	86	P56178
YYSFYCNPQPCFIYL	ADIPOR2	236	Q86V24
FEYKRSETPSRYYCY	NFXL1	221	Q6ZNB6
YYNYFFVSYDSSVTC	SMPDL3A	406	Q92484
AQYYYTFKSFYFPMS	F13B	36	P05160
VVTFYYAPFAYTYLC	OR2L5	246	Q8NG80
CYAELSPYNLYFYSL	PLEKHM3	231	Q6ZWE6
IAGYTPYAECDFYYS	FRMD4B	806	Q9Y2L6
YYFIPYIVTPCADYF	MAP3K15	181	Q6ZN16
CSESSFFAKIPYYYY	SP140L	486	Q9H930
FFAKIPYYYYIREAC	SP140L	491	Q9H930
VPFFLCYNYPVSDYY	SGPP2	256	Q8IWX5
LSYFMAYYKYCTSEH	RNF17	1346	Q9BXT8
FYSNLPTYYDNCSFY	TPTE	481	P56180
PFHYLFYTGKQSYYS	MRPS9	146	P82933
SSFFAKIPYYYYIRE	SP140	776	Q13342
MKPYNYCSAYESFYE	NEUROD6	231	Q96NK8
MSSFSYEPYYSTSYK	NEFL	1	P07196