Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNH6 KCNH7 ATP12A TMEM87A KCNH2 KCNH4 KCNH3 KCNH5

2.29e-09167438GO:0015079
GeneOntologyMolecularFunctionpotassium channel activity

KCNH6 KCNH7 TMEM87A KCNH2 KCNH4 KCNH3 KCNH5

1.00e-08128437GO:0005267
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

8.01e-08102436GO:0005249
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

8.51e-07152436GO:0022843
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

2.43e-06182436GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

2.59e-06184436GO:0022832
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNH6 KCNH7 ATP12A TMEM87A KCNH2 KCNH4 KCNH3 KCNH5

5.77e-06465438GO:0046873
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

KCNH6 KCNH7 ATP12A TMEM87A SLC15A4 KCNH2 KCNH4 KCNH3 KCNH5

6.08e-06627439GO:0022890
GeneOntologyMolecularFunctiongated channel activity

KCNH6 KCNH7 TMEM87A KCNH2 KCNH4 KCNH3 KCNH5

6.61e-06334437GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNH6 KCNH7 TMEM87A KCNH2 KCNH4 KCNH3 KCNH5

7.86e-06343437GO:0005261
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNH6 KCNH7 ATP12A TMEM87A SLC15A4 KCNH2 KCNH4 KCNH3 KCNH5

9.64e-06664439GO:0008324
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

KCNH6 KCNH7 ATP12A TMEM87A SLC15A4 KCNH2 KCNH4 KCNH3 KCNH5

2.76e-05758439GO:0015318
GeneOntologyMolecularFunctioninward rectifier potassium channel activity

KCNH6 KCNH7 KCNH2

2.93e-0528433GO:0005242
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

KCNH6 KCNH7 ATP12A TMEM87A SLC15A4 KCNH2 KCNH4 KCNH3 KCNH5

3.93e-05793439GO:0015075
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNH6 KCNH7 TMEM87A KCNH2 KCNH4 KCNH3 KCNH5

5.10e-05459437GO:0005216
GeneOntologyMolecularFunctionchannel activity

KCNH6 KCNH7 TMEM87A KCNH2 KCNH4 KCNH3 KCNH5

1.18e-04525437GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNH6 KCNH7 TMEM87A KCNH2 KCNH4 KCNH3 KCNH5

1.20e-04526437GO:0022803
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2C KMT2D

1.26e-048432GO:0140945
GeneOntologyMolecularFunctiontransmembrane transporter activity

KCNH6 NAT1 KCNH7 ATP12A TMEM87A SLC15A4 KCNH2 KCNH4 KCNH3 KCNH5

1.60e-0411804310GO:0022857
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2C KMT2D

2.02e-0410432GO:0140999
GeneOntologyMolecularFunctiontransporter activity

KCNH6 NAT1 KCNH7 ATP12A TMEM87A SLC15A4 KCNH2 KCNH4 KCNH3 KCNH5

3.27e-0412894310GO:0005215
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2C KMT2D

8.40e-0420432GO:0042800
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNHD1 HTT

2.88e-0337432GO:0045505
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

KCNH6 KCNH7 KCNH2

3.39e-03140433GO:0099094
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2C KMT2D

4.05e-0344432GO:0140938
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

KMT2C KMT2D TARBP1

6.02e-03172433GO:0008757
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

KCNH6 KCNH7 ATP12A P2RY12 KCNH2 KCNH4 KCNH3 KCNH5

1.93e-08232428GO:0071805
GeneOntologyBiologicalProcesspotassium ion transport

KCNH6 KCNH7 ATP12A P2RY12 KCNH2 KCNH4 KCNH3 KCNH5

6.61e-08272428GO:0006813
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

KCNH6 KCNH7 ATP12A P2RY12 SLC15A4 KCNH2 FFAR1 KCNH4 HTT KCNH3 KCNH5

1.61e-069224211GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

KCNH6 KCNH7 ATP12A P2RY12 SLC15A4 KCNH2 FFAR1 KCNH4 HTT KCNH3 KCNH5

1.98e-069424211GO:0098655
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

KCNH6 KCNH7 ATP12A P2RY12 SLC15A4 KCNH2 FFAR1 KCNH4 HTT KCNH3 KCNH5

4.15e-0610174211GO:0098660
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

KCNH6 KCNH7 ATP12A P2RY12 SLC15A4 KCNH2 FFAR1 KCNH4 HTT KCNH3 KCNH5

9.97e-0611154211GO:0034220
GeneOntologyBiologicalProcessmonoatomic cation transport

KCNH6 KCNH7 ATP12A P2RY12 SLC15A4 KCNH2 FFAR1 KCNH4 HTT KCNH3 KCNH5

1.41e-0511574211GO:0006812
GeneOntologyBiologicalProcessmetal ion transport

KCNH6 KCNH7 ATP12A P2RY12 KCNH2 FFAR1 KCNH4 HTT KCNH3 KCNH5

2.44e-0510004210GO:0030001
GeneOntologyBiologicalProcessmonoatomic ion transport

KCNH6 KCNH7 ATP12A P2RY12 SLC15A4 KCNH2 FFAR1 KCNH4 HTT KCNH3 KCNH5

6.90e-0513744211GO:0006811
GeneOntologyBiologicalProcesslong-chain fatty acid catabolic process

CYP4F2 AIG1

2.64e-0412422GO:0042758
GeneOntologyBiologicalProcesstoll-like receptor 7 signaling pathway

UNC93B1 SLC15A4

2.64e-0412422GO:0034154
GeneOntologyBiologicalProcesspositive regulation of transport

NRDE2 EEF2K CYP4F2 SMPD3 FCN3 P2RY12 KCNH2 FFAR1 HTT

2.68e-041081429GO:0051050
GeneOntologyCellularComponenttransmembrane transporter complex

KCNH6 KCNH7 ATP12A KCNH2 KCNH4 KCNH3 KCNH5

8.70e-05523437GO:1902495
GeneOntologyCellularComponentmonoatomic ion channel complex

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.16e-04378436GO:0034702
GeneOntologyCellularComponenttransporter complex

KCNH6 KCNH7 ATP12A KCNH2 KCNH4 KCNH3 KCNH5

1.19e-04550437GO:1990351
GeneOntologyCellularComponentMLL3/4 complex

KMT2C KMT2D

2.69e-0412432GO:0044666
GeneOntologyCellularComponentvoltage-gated potassium channel complex

KCNH2 KCNH4 KCNH5

8.68e-0491433GO:0008076
GeneOntologyCellularComponentpotassium channel complex

KCNH2 KCNH4 KCNH5

1.28e-03104433GO:0034705
DomainPAS_9

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.86e-1410426PF13426
DomainK_chnl_volt-dep_EAG/ELK/ERG

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

2.64e-1314426IPR003938
DomainPAS-assoc_C

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.16e-1124426IPR000700
DomainPAC

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.98e-1126426SM00086
DomainPAC

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.98e-1126426PS50113
DomainPAC

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.98e-1126426IPR001610
DomainCNMP_BINDING_1

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

7.73e-1132426PS00888
DomainCNMP_BINDING_2

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

7.73e-1132426PS00889
DomaincNMP

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.14e-1034426SM00100
DomainPAS

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.14e-1034426IPR000014
DomainPAS

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.14e-1034426PS50112
DomaincNMP_binding

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.14e-1034426PF00027
DomaincNMP-bd_dom

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.38e-1035426IPR000595
DomainCNMP_BINDING_3

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.38e-1035426PS50042
DomaincNMP-bd-like

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

2.33e-1038426IPR018490
Domain-

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.02e-09484262.60.120.10
DomainRmlC-like_jellyroll

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.49e-0951426IPR014710
DomainPAS

KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

8.66e-0932425SM00091
DomainK_chnl_volt-dep_ERG

KCNH6 KCNH7 KCNH2

1.06e-083423IPR003967
DomainIon_trans_dom

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.99e-07114426IPR005821
DomainIon_trans

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.99e-07114426PF00520
DomainK_chnl_volt-dep_ELK

KCNH4 KCNH3

1.48e-053422IPR003950
DomainPAS_fold_3

KCNH7 KCNH4 KCNH3

1.81e-0523423IPR013655
DomainPAS_3

KCNH7 KCNH4 KCNH3

1.81e-0523423PF08447
DomainPAS

KCNH6 KCNH2 KCNH5

2.35e-0525423PF00989
DomainPAS_fold

KCNH6 KCNH2 KCNH5

2.35e-0525423IPR013767
DomainFYrich_C

KMT2C KMT2D

4.92e-055422IPR003889
DomainFYrich_N

KMT2C KMT2D

4.92e-055422IPR003888
DomainFYRC

KMT2C KMT2D

4.92e-055422SM00542
DomainFYRN

KMT2C KMT2D

4.92e-055422SM00541
DomainFYRN

KMT2C KMT2D

4.92e-055422PF05964
DomainFYRC

KMT2C KMT2D

4.92e-055422PF05965
DomainFYRC

KMT2C KMT2D

4.92e-055422PS51543
DomainFYRN

KMT2C KMT2D

4.92e-055422PS51542
DomainCENP-B_N

TIGD3 TIGD6

2.20e-0410422PF04218
DomainCENPB

TIGD3 TIGD6

3.21e-0412422SM00674
DomainHTH_Psq

TIGD3 TIGD6

3.21e-0412422IPR007889
DomainDDE_1

TIGD3 TIGD6

3.21e-0412422PF03184
DomainHTH_PSQ

TIGD3 TIGD6

3.21e-0412422PS50960
DomainDDE_SF_endonuclease_dom

TIGD3 TIGD6

3.21e-0412422IPR004875
DomainHTH_Tnp_Tc5

TIGD3 TIGD6

3.79e-0413422PF03221
DomainHTH_CenpB_DNA-bd_dom

TIGD3 TIGD6

3.79e-0413422IPR006600
DomainHTH_CENPB

TIGD3 TIGD6

3.79e-0413422PS51253
DomainPost-SET_dom

KMT2C KMT2D

5.81e-0416422IPR003616
DomainPostSET

KMT2C KMT2D

5.81e-0416422SM00508
DomainPOST_SET

KMT2C KMT2D

5.81e-0416422PS50868
DomainEPHD

KMT2C KMT2D

1.11e-0322422PS51805
DomainSET

KMT2C KMT2D

3.83e-0341422PF00856
DomainSET

KMT2C KMT2D

4.80e-0346422SM00317
DomainSET_dom

KMT2C KMT2D

5.65e-0350422IPR001214
DomainSET

KMT2C KMT2D

5.65e-0350422PS50280
DomainHMG_box

KMT2C KMT2D

6.33e-0353422PF00505
DomainHMG

KMT2C KMT2D

6.56e-0354422SM00398
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.48e-1041286MM14546
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

2.01e-1043286M1056
PathwayREACTOME_POTASSIUM_CHANNELS

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

3.22e-0898286MM14545
PathwayREACTOME_POTASSIUM_CHANNELS

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

4.34e-08103286M1073
PathwayREACTOME_NEURONAL_SYSTEM

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

4.17e-05335286MM14503
PathwayREACTOME_NEURONAL_SYSTEM

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

1.29e-04411286M735
Pubmed

Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

5.19e-161043626503718
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

9.23e-124043616382104
Pubmed

Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.

KCNH6 KCNH7 KCNH2

1.76e-09343335818223
Pubmed

Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3.

KCNH6 KCNH7 KCNH2

1.76e-09343314643686
Pubmed

HERG K(+) currents in human prolactin-secreting adenoma cells.

KCNH6 KCNH7 KCNH2

1.76e-09343312634931
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

1.49e-06243228483418
Pubmed

New ether-à-go-go K(+) channel family members localized in human telencephalon.

KCNH4 KCNH3

1.49e-06243210455180
Pubmed

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

KMT2C KMT2D

1.49e-06243236869380
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

1.49e-06243228967912
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

1.49e-06243234156443
Pubmed

Ether-à-go-go-related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neurons.

KCNH7 KCNH2

1.49e-06243219359372
Pubmed

Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.

KMT2C KMT2D

1.49e-06243225346535
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

1.49e-06243231924266
Pubmed

Functional analysis of a mouse brain Elk-type K+ channel.

KCNH2 KCNH3

1.49e-06243210191308
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

1.49e-06243227280393
Pubmed

The eag family of K+ channels in Drosophila and mammals.

KCNH6 KCNH7

1.49e-06243210414305
Pubmed

Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.

KMT2C KMT2D

1.49e-06243236601880
Pubmed

Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.

KMT2C KMT2D

4.48e-06343222183980
Pubmed

Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization.

KCNH7 KCNH2

4.48e-06343215961404
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2C KMT2D

4.48e-06343223932714
Pubmed

HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.

KMT2C KMT2D

4.48e-06343221683083
Pubmed

Distribution and functional properties of human KCNH8 (Elk1) potassium channels.

KCNH4 KCNH3

4.48e-06343212890647
Pubmed

Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis.

KCNH6 KCNH7 KCNH2

4.49e-062643331138815
Pubmed

Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.

KMT2C KMT2D

8.94e-06443219221051
Pubmed

Cancer gene mutation frequencies for the U.S. population.

KMT2C KMT2D

8.94e-06443234645806
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2C KMT2D

8.94e-06443228398509
Pubmed

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.

KMT2C KMT2D

8.94e-06443224081332
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2C KMT2D

8.94e-06443223129768
Pubmed

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.

KMT2C KMT2D

1.49e-05543232601106
Pubmed

Differences in neuroinvasion and protective innate immune pathways between encephalitic California Serogroup orthobunyaviruses.

IRF3 UNC93B1

1.49e-05543235245345
Pubmed

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

KMT2C KMT2D

1.49e-05543231127101
Pubmed

Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus.

IRF3 UNC93B1

1.49e-05543220592086
Pubmed

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

KMT2C KMT2D

1.49e-05543226744420
Pubmed

Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN.

UNC93B1 SLC15A4

2.23e-05643229055005
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C KMT2D

2.23e-05643217021013
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

KCNH6 KCNH7 KCNH2 KCNH3

2.67e-0513943416985003
Pubmed

Age-dependent myeloid dendritic cell responses mediate resistance to la crosse virus-induced neurological disease.

IRF3 UNC93B1

3.12e-05743225008929
Pubmed

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.

KMT2C KMT2D

3.12e-05743230604749
Pubmed

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.

KMT2C KMT2D

3.12e-05743236598580
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2C KMT2D

3.12e-05743219556342
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

KMT2C KMT2D RAB3GAP2

3.31e-055043337974198
Pubmed

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.

KMT2C KMT2D

4.16e-05843230335158
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2C KMT2D

4.16e-05843223130995
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2C KMT2D

4.16e-05843222266653
Pubmed

Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.

KMT2C KMT2D

4.16e-05843221447625
Pubmed

In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration.

IRF3 UNC93B1

5.35e-05943226880763
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2C KMT2D

5.35e-05943222665483
Pubmed

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.

KCNH2 KCNH5

6.68e-051043222855790
Pubmed

MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.

KMT2C KMT2D

8.15e-051143237012455
Pubmed

Toll-like receptor 7 mediates early innate immune responses to malaria.

IRF3 UNC93B1

9.78e-051243224042114
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2C KMT2D

9.78e-051243227563068
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

KMT2C KMT2D

1.15e-041343217761849
Pubmed

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.

UNC93B1 SLC15A4

1.15e-041343212935356
Pubmed

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.

KMT2C KMT2D

1.15e-041343221502505
Pubmed

Recognition of fungal RNA by TLR7 has a nonredundant role in host defense against experimental candidiasis.

IRF3 UNC93B1

1.35e-041443222777843
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

KMT2C KMT2D

1.35e-041443212482968
Pubmed

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.

UNC93B1 SLC15A4

1.55e-041543221045126
Pubmed

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

KMT2C KMT2D

1.55e-041543217925232
Pubmed

Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.

P2RY12 HTT

1.77e-041643227721240
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

KMT2C KMT2D

1.77e-041643224368734
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

CHD2 TMEM87A TARBP1 RAB3GAP2 TIGD6 KCNH5

1.89e-0468643629987050
Pubmed

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.

KMT2C KMT2D

2.01e-041743226180087
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

KMT2C KMT2D

2.26e-041843217500065
Pubmed

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.

IRF3 UNC93B1

2.52e-041943228400473
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

KMT2C KMT2D

2.80e-042043229785026
Pubmed

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

KMT2C KMT2D

2.80e-042043219047629
Pubmed

The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.

KMT2C KMT2D

2.80e-042043233431871
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2C KMT2D

3.09e-042143227626377
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2C KMT2D

3.40e-042243226886794
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FBRSL1 TIGD3 KMT2C KMT2D KCNH2 HTT KCNH3

3.80e-04110543735748872
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

KMT2C KMT2D TARBP1

4.36e-0411943323508102
Pubmed

Identification and characterization of a novel human PP1 phosphatase complex.

KMT2C KMT2D

6.79e-043143220516061
Pubmed

MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.

KMT2C KMT2D

7.69e-043343232439762
InteractionKCNH4 interactions

KCNH6 KCNH2 KCNH4 KCNH3 KCNH5

2.41e-1112425int:KCNH4
InteractionKCNH6 interactions

KCNH6 KCNH4

4.24e-062422int:KCNH6
InteractionKCNH3 interactions

KCNH4 KCNH3

4.22e-055422int:KCNH3
Cytoband7q36.1

KMT2C KCNH2

2.22e-03744327q36.1
GeneFamilyPotassium voltage-gated channels

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

7.78e-1240236274
GeneFamilyHelix-turn-helix CENPB type domain containing

TIGD3 TIGD6

1.20e-0413232533
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C KMT2D

8.47e-0434232487
GeneFamilyPHD finger proteins

KMT2C KMT2D

5.79e-039023288
GeneFamilyEndogenous ligands

BMP5 HTT

3.61e-02237232542
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCNH6 CYP4F2 KCNH7 KCNH2 KCNH5

1.25e-0619643595544097577f20ed7f4144bd940471cde0617554
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1|Striatum / BrainAtlas - Mouse McCarroll V32

SMPD3 KCNH4 KCNH3 KCNH5

1.19e-051464347b863f9bc63dc1afe015a18a70cd6ed0b71d1f09
ToppCellGlobus_pallidus-Neuronal-Excitatory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SMPD3 KCNH4 KCNH3 KCNH5

1.71e-05160434f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SMPD3 KCNH4 KCNH3 KCNH5

1.75e-05161434ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCellILEUM-inflamed-(3)_pDC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TIGD3 UNC93B1 SMPD3 SLC15A4

2.48e-05176434b9f847dd55703e413f3cd815eef5724fffaf13b3
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

KCNH6 KCNH7 SMPD3 KCNH2

2.83e-0518243457bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KCNH6 KCNH7 SMPD3 KCNH2

3.08e-05186434b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KCNH6 KCNH7 SMPD3 KCNH2

3.21e-05188434c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH6 KCNH7 KCNH2 KCNH5

3.34e-0519043440d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH6 KCNH7 KCNH2 KCNH5

3.34e-05190434f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH6 KCNH7 KCNH2 KCNH5

3.34e-05190434a9a705455019e28d655636de73b07540798f82e6
ToppCell11.5-Airway-Epithelial-Neuroendocrine|Airway / Age, Tissue, Lineage and Cell class

TIGD3 KCNH6 SMPD3 KCNH2

3.41e-05191434c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCNH6 KCNH7 SMPD3 KCNH2

3.93e-051984348f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCNH6 KCNH7 SMPD3 KCNH2

3.93e-05198434e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellMS-IIF-Myeloid-pDC|IIF / Disease, condition lineage and cell class

TIGD3 UNC93B1 SMPD3 SLC15A4

4.00e-05199434e262ee854e64d87460bee810c14d6cbe744460e8
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c3-LAMP3|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TMEM150B DNHD1 HTT

3.25e-04139433bb2b020dda32ddc60ec9952de5b01acee60b5b59
ToppCelldroplet-Lung-nan-3m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM150B NAT1 UNC93B1

3.76e-04146433ed932d43e9efd064ee4b49ddef529f3d041be765
ToppCelldroplet-Lung-nan-3m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM150B NAT1 UNC93B1

3.76e-041464330d74962779055c774312d59fc3b1365163741c3a
ToppCellControl-Epithelial-PNEC|World / Disease state, Lineage and Cell class

KCNH6 KCNH7 KCNH2

3.99e-0414943302b47193621d23a50378d7905d7f85aaab686cfb
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UNC93B1 SMPD3 P2RY12

4.47e-0415543393bfcf5c12cbb61a1e0444312afd2aa411a8bf50
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

TMEM254 SMPD3 LXN

4.73e-041584334d997efc36fd8946775fe74dd9ac9ccd5ade64ff
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

TIGD3 SMPD3 SLC15A4

4.73e-041584332af7beb48272e5368d9ba6b80f08d47ab8556c08
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|367C / Donor, Lineage, Cell class and subclass (all cells)

TMEM254 IRF3 SLC15A4

5.00e-04161433f470b662566131dfe69a2fd01186ac8491196396
ToppCellLAM-Lymphoid-pDC|LAM / Condition, Lineage and Cell class

TIGD3 SMPD3 SLC15A4

5.00e-04161433bb5b44713e4da4406cdaa79dcf2aa9f97e3cf75a
ToppCell390C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNHD1 SMPD3 FCN3

5.09e-04162433fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCell390C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNHD1 SMPD3 FCN3

5.09e-0416243345be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCellILEUM-non-inflamed-(3)_pDC|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TIGD3 SMPD3 SLC15A4

5.18e-04163433bc5411702badab39143905aa51676b4bbfad2041
ToppCellmild-Myeloid-Eosinophils|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

EEF2K SMPD3 KCNH2

5.18e-041634337c57d541a88e9afa079e95b8a6ecdea60a0c6aaa
ToppCellFrontal_cortex|World / BrainAtlas - Mouse McCarroll V32

KCNH7 ATP12A KCNH3

5.27e-04164433e09291711abf8680e78170328313719092b0142f
ToppCellmetastatic_Brain-Myeloid_cells-pDCs|metastatic_Brain / Location, Cell class and cell subclass

TIGD3 SMPD3 SLC15A4

5.27e-0416443306db4cc064f0765c481ce880207823872c27bfa9
ToppCellCOVID-19-lung-Mesothelial|COVID-19 / Disease (COVID-19 only), tissue and cell type

SMPD3 LXN KCNH5

5.27e-0416443383303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TIGD3 FBN2 KCNH2

5.37e-041654333d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCelldroplet-Lung-LUNG-1m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM150B UNC93B1 PGGHG

5.46e-04166433c215c4aede38d355d35fd26cd7ef2c19efecd0e6
ToppCellfacs-Tongue-nan-3m-Epithelial-basal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS11F P2RY12 SLC15A4

5.66e-04168433ca0c4a819f9047fc40d224f7656fec60f6fa05d8
ToppCell390C-Myeloid-Dendritic-pDC|390C / Donor, Lineage, Cell class and subclass (all cells)

TIGD3 UNC93B1 SMPD3

5.66e-041684335a2e7a52b7330dce30823695a7b9b26bc47a69ce
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNH6 CYP4F2 FFAR1

5.66e-041684330f736d58cb0ff042fa3ce58e36bde37b6976f8fc
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|metastatic_Brain / Location, Cell class and cell subclass

UNC93B1 SMPD3 SLC15A4

5.75e-0416943371f6761b9927f352e0ccc221ca373319915f4184
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM150B UNC93B1 PGGHG

5.75e-04169433735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-5|TCGA-Bladder / Sample_Type by Project: Shred V9

TIGD3 KCNH6 KCNH3

5.75e-041694339c4e83fe8225d16173a103bf5a57b17d623be923
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

KCNH6 KCNH7 KCNH2

5.75e-04169433b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellsevere-Myeloid-Eosinophils|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

EEF2K SMPD3 KCNH2

5.85e-04170433863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCelldroplet-Lung-nan-18m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM202 TMEM150B P2RY12

5.95e-041714337ca404539344e14dcd90c746c9122f713a7db78b
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TIGD3 SMPD3 SLC15A4

5.95e-041714334fd2c7977c512c51507f055fc74b111c0228ed8b
ToppCelldroplet-Lung-nan-18m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM202 TMEM150B P2RY12

5.95e-04171433ab113c8e773b0af47a87aed50e96be3ba71c3c82
ToppCellCOVID_vent-Lymphocytic-Dendritic-pDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

SMPD3 SLC15A4 TARBP1

5.95e-04171433779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCellCOVID_vent-Lymphocytic-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

SMPD3 SLC15A4 TARBP1

5.95e-04171433debbb071d260639b16269c94d172766908325c58
ToppCellnucseq-Epithelial-Epithelial_Neuro-Secretory-PNEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KCNH6 KCNH7 KCNH2

5.95e-04171433f4321133190a3df9d31f5d4021a464d3840145f1
ToppCellmild-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

EEF2K SMPD3 KCNH2

5.95e-041714335c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCellnucseq-Epithelial-Epithelial_Neuro-Secretory-PNEC-PNEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KCNH6 KCNH7 KCNH2

5.95e-04171433ed4fb6c84579d99df33de5f8f928c3cd2f3d3d72
ToppCell390C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TIGD3 SMPD3 SLC15A4

6.06e-041724333f894c74916d49a995b2d4651ca1c6733c14ce9c
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

KCNH7 SMPD3 KCNH3

6.06e-04172433200b2e63313b110b8ca59ee5b72c02cc8ed907cd
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UNC93B1 SMPD3 SLC15A4

6.06e-04172433b84610f1e5889a655652800c2b3270d264bfe1a9
ToppCellnucseq-Epithelial-Epithelial_Neuro-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KCNH6 KCNH7 KCNH2

6.06e-04172433d0cdedd734406988a9a93d7300c7b1a8b4b45c38
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBRSL1 SMPD3 TMEM87A

6.16e-041734334968712af1cca8c932abd3323631d7dcaffd4a66
ToppCellwk_15-18-Hematologic-Myeloid-pDC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

UNC93B1 SMPD3 SLC15A4

6.16e-04173433b571970e3ba88afc07041c5692ccfd85fc39e796
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EEF2K LXN KCNH4

6.26e-04174433b2fc2a756f8e373ad903bd416d9de703d945fa1c
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-4|TCGA-Adrenal / Sample_Type by Project: Shred V9

TMEM254 CHD2 FBN2

6.26e-0417443315e2b9f46404ff9575e149024b24cb17b50b02b5
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EEF2K LXN KCNH4

6.26e-041744330fccd90ef72ec2e5eb369fe6d6d126c60886485a
ToppCellIIF-Myeloid-pDC|IIF / Disease, Lineage and Cell Type

UNC93B1 SMPD3 SLC15A4

6.37e-0417543335cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

KCNH7 KCNH2 FFAR1

6.37e-041754334db1a3c284488b3f6de7568363f176d74e2a4587
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

KCNH7 KCNH2 FFAR1

6.37e-041754338d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNH6 KCNH7 FFAR1

6.37e-04175433c031da47ca63d1133e13530cbf779df9435e22cb
ToppCellCF-Lymphoid-pDC|CF / Disease state, Lineage and Cell class

EEF2K SMPD3 TARBP1

6.47e-04176433dd1e529a9e413bcaab43584afbe059e1464ffb53
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TIGD3 SMPD3 SLC15A4

6.58e-04177433507f06d31ab773099c9431b6f433899dc97b5566
ToppCellwk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

KY KCNH4 KCNH5

6.58e-0417743315a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP5 FBN2 KCNH2

6.58e-04177433e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TIGD3 SMPD3 SLC15A4

6.58e-041774338887ff6341eb070bdaa890cc2cd7745f0cf1b0af
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KY BMP5 KCNH3

6.58e-04177433dbdbdc8ed9ef0b529694242ef9f9f07a42e16005
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KY BMP5 KCNH3

6.69e-04178433416f85e51f45ec7949451fd47611a84e33e87245
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMPD3 SLC15A4 TARBP1

6.80e-04179433c9f45cfea0ceb0cdc31bcfd123aeab69aeb35c35
ToppCellwk_20-22-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KCNH6 ATP12A KCNH2

6.80e-0417943306f92c884189197c86793191c05f65e34925c097
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-pDC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UNC93B1 SMPD3 SLC15A4

6.80e-04179433bbd4f8e988ef3f343aaedbc992b70f2bb6aff5f6
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC93B1 SMPD3 SLC15A4

6.91e-041804336a2366d76276452141db1bd93013a9503525f574
ToppCellsevere-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

EEF2K SMPD3 KCNH2

6.91e-04180433ac03812b1409435c55d323a7516deeac82bd3509
ToppCelltumor_Lung-Myeloid_cells-pDCs|tumor_Lung / Location, Cell class and cell subclass

UNC93B1 SMPD3 SLC15A4

7.02e-04181433c864ffeb9234b8c29754afc91c85a972889617f4
ToppCellwk_20-22-Hematologic-Myeloid-pDC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

UNC93B1 SMPD3 SLC15A4

7.02e-0418143360607c5ff6d5b1cb416adc034491dca31c41e988
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_PP_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNH6 NAT1 KCNH2

7.13e-04182433eb4be1c02b8b033d025e57b8b4cdbfaec4698054
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

UNC93B1 SMPD3 SLC15A4

7.13e-041824339bbe8062aa562dc3b9c299581faf6ebbcb72a9f7
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KMT2D KCNH7 SMPD3

7.13e-041824331923932a9c60e9ec33db69ded441210d1fb07bec
ToppCell5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNH6 KCNH7 FFAR1

7.13e-0418243327a27a3eaeacb087c9601d5bb1c9e57cdfcd9d77
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

UNC93B1 SMPD3 SLC15A4

7.13e-041824334602a98df7045e2c70b7560abfba9b444fbd5d30
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KMT2D KCNH7 SMPD3

7.13e-0418243369ff652f74cc47fbe0bd665ab17c445c5b959dad
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UNC93B1 SMPD3 SLC15A4

7.25e-04183433df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP5 FBN2 KCNH2

7.25e-04183433af8d86f15a549064530d94bd47081daf59d58ecd
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UNC93B1 SMPD3 SLC15A4

7.25e-041834333b123571e10c132227aff65648b4b3c6acb4bd00
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|World / Lineage, cell class and subclass

UNC93B1 SMPD3 SLC15A4

7.36e-0418443311619778bc773ecd1a9867330be04deaf324f31e
ToppCellcontrol-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PHTF2 EEF2K KCNH2

7.36e-04184433fad517d047e8eaeaa5bd4f311d770880568dd13c
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-pDC|bone_marrow / Manually curated celltypes from each tissue

UNC93B1 SMPD3 SLC15A4

7.36e-041844332817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KY BMP5 FBN2

7.48e-041854338ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCellLeuk-UTI-Other-RBC|Leuk-UTI / Disease, Lineage and Cell Type

UNC93B1 SMPD3 SLC15A4

7.48e-041854335b5dd856d6efc0539d92533cff134bbc3f98be45
ToppCellLeuk-UTI-Other|Leuk-UTI / Disease, Lineage and Cell Type

UNC93B1 SMPD3 SLC15A4

7.48e-04185433895e8087e97ac0eab3446385e6e0dd24bea7f42c
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KY BMP5 FBN2

7.48e-04185433b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCellILEUM-inflamed-(3)_MNP-(3)_pDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TIGD3 SMPD3 SLC15A4

7.48e-04185433308a98f111895071d8772bc010554471cc12fab2
ToppCellhealthy_donor-Lymphocytic-Dendritic|healthy_donor / Disease condition, Lineage, Cell class and subclass

UNC93B1 SMPD3 SLC15A4

7.60e-04186433916f2aeea4989ba7a29e071e348a51010f010223
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

UNC93B1 SMPD3 SLC15A4

7.60e-04186433b70cd94c651b56dcf2e55554533a5f1130845390
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

UNC93B1 SMPD3 SLC15A4

7.60e-0418643331df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCNH6 KCNH7 SMPD3

7.60e-04186433c7983281a290201567b398e9ea6baddb96c692bb
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

UNC93B1 SMPD3 SLC15A4

7.60e-04186433a07694caf7fede06a47636725bcc7f09909cdf07
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

UNC93B1 SMPD3 SLC15A4

7.60e-04186433eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCellMultiple_Sclerosis-Myeloid-pDC|Multiple_Sclerosis / Disease, Lineage and Cell Type

UNC93B1 SMPD3 SLC15A4

7.60e-04186433330a4f669adea91ff9f2dff2de2210f5e3401e19
DrugWAY-123,398

KCNH6 KCNH7 KCNH2 KCNH3 KCNH5

4.73e-1210435CID000132160
DrugHdba

KCNH6 KCNH7 KCNH2 KCNH5

4.19e-0819434CID000003896
DrugMK-499

KCNH6 KCNH7 KCNH2 KCNH5

4.19e-0819434CID000127718
Drugpyraclofos

KCNH6 KCNH7 KCNH2 KCNH4 KCNH3 KCNH5

4.68e-08106436CID000093460
DrugE 4031

KCNH6 KCNH7 KCNH2 KCNH3 KCNH5

5.58e-0854435CID000003184
Drugether-a

KCNH6 KCNH7 KCNH2 KCNH5

7.87e-0822434CID000501025
Drugterfenadine

KCNH6 KCNH7 KCNH2 KCNH3 KCNH5

1.04e-0761435CID000005405
Drugdofetilide

KCNH6 KCNH7 KCNH2 KCNH3 KCNH5

1.22e-0763435CID000071329
DrugDoxazosin

KCNH6 KCNH7 KCNH2

1.25e-076433DB00590
DrugPrazosin

KCNH6 KCNH7 KCNH2

1.25e-076433DB00457
DrugTerazosin

KCNH6 KCNH7 KCNH2

1.25e-076433DB01162
DrugMiconazole

KCNH6 KCNH7 KCNH2

3.49e-078433DB01110
DrugXE991

KCNH6 KCNH7 KCNH2 KCNH5

4.34e-0733434CID000656732
DrugIbutilide

KCNH6 KCNH7 KCNH2

7.46e-0710433DB00308
Druglinopirdine

KCNH6 KCNH7 KCNH2 KCNH3

1.29e-0643434CID000003932
Drugastemizole

KCNH6 KCNH7 KCNH2 KCNH3

1.55e-0645434CID000002247
Drugsertindole

KCNH6 KCNH7 KCNH2 KCNH5

2.38e-0650434CID000060149
Drugziprasidone

KCNH6 KCNH7 KCNH2 KCNH5

3.02e-0653434CID000060853
DrugN-(1-(2,3-dimethoxyphenyl)-4-methyl-3-penten-1-yl)-1-(5-bromofurfuryl)-1-piperidyl-4-amine

KCNH6 KCNH2

3.48e-062432ctd:C531033
DrugW-A-Y

KCNH6 KCNH7 KCNH2 KCNH3

3.77e-0656434CID000004368
Drugquetiapine

KCNH6 KCNH7 KCNH2 KCNH5

4.05e-0657434CID000005002
Drugclofilium

KCNH6 KCNH7 KCNH2 KCNH5

1.15e-0574434CID000002798
Drugthioridazine

KCNH6 KCNH7 KCNH2 KCNH5

1.49e-0579434CID000005452
DrugNS1643

KCNH6 KCNH2

2.09e-054432CID010177784
Drugcisapride

KCNH6 KCNH7 KCNH2 KCNH5

5.91e-05112434CID000002769
Drugether

KCNH6 KCNH7 KCNH2 KCNH5

6.11e-05113434CID000003283
DrugmM Q

KCNH6 KCNH7 KCNH2

6.36e-0541433CID000445446
Drugdiazoxide

KCNH6 KCNH7 KCNH2 FFAR1 KCNH5

6.66e-05227435CID000003019
DrugAC1MRHRO

KCNH6 KCNH7 FFAR1

7.35e-0543433CID003468412
Drugpimozide

KCNH6 KCNH7 KCNH2 KCNH5

9.63e-05127434CID000016362
DrugRubidium

ATP12A KCNH2

9.69e-058432ctd:D012413
Drugolanzapine

KCNH6 KCNH7 KCNH2 KCNH5

1.02e-04129434CID000004585
Drugpiperidine

KCNH6 KCNH7 KCNH2 KCNH3

1.05e-04130434CID000008082
Drugrisperidone

KCNH6 KCNH7 KCNH2 KCNH5

1.25e-04136434CID000005073
Drugcarbanilide

KCNH6 KCNH2

1.90e-0411432CID000007595
Diseaselong QT syndrome (implicated_via_orthology)

KCNH6 KCNH7 KCNH2

2.97e-0710413DOID:2843 (implicated_via_orthology)
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

1.88e-062412DOID:0080598 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

KCNH6 KCNH7 ATP12A KCNH2 KCNH5

3.09e-06163415DOID:1826 (implicated_via_orthology)
Diseaseshort QT syndrome (implicated_via_orthology)

KCNH6 KCNH2

5.65e-063412DOID:0050793 (implicated_via_orthology)
Diseaseheart conduction disease (implicated_via_orthology)

KCNH6 KCNH7 KCNH2

1.20e-0532413DOID:10273 (implicated_via_orthology)
DiseaseHerpetic Acute Necrotizing Encephalitis

IRF3 UNC93B1

1.88e-055412C0001338
DiseaseHerpetic meningoencephalitis

IRF3 UNC93B1

2.82e-056412C0019385
DiseaseHerpes encephalitis

IRF3 UNC93B1

3.94e-057412C0276226
Diseasebrain disease (is_implicated_in)

IRF3 UNC93B1

1.23e-0412412DOID:936 (is_implicated_in)
DiseaseMethionine sulfoxide measurement

KCNH6 SLC15A4

1.23e-0412412EFO_0021650
DiseaseSezary Syndrome

KMT2C KMT2D

6.47e-0427412C0036920
Diseaselung non-small cell carcinoma (is_implicated_in)

NAT1 KMT2C KMT2D

9.57e-04139413DOID:3908 (is_implicated_in)
DiseaseBladder Neoplasm

NAT1 KMT2C KMT2D

9.77e-04140413C0005695
DiseaseMalignant neoplasm of urinary bladder

NAT1 KMT2C KMT2D

9.97e-04141413C0005684
DiseaseCongenital small ears

BMP5 KMT2D

1.49e-0341412C0152423
Diseaseoral microbiome measurement

KMT2C ATP12A

1.57e-0342412EFO_0801229
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

KMT2C KMT2D

1.80e-0345412DOID:3748 (is_implicated_in)
DiseaseHernia

KY AIG1

2.30e-0351412HP_0100790
DiseaseLibman-Sacks Disease

P2RY12 SLC15A4

2.96e-0358412C0242380
DiseaseBenign Neoplasm

NAT1 KCNH2

4.05e-0368412C0086692
DiseaseNeoplasms

NAT1 KCNH2

4.05e-0368412C0027651

Protein segments in the cluster

PeptideGeneStartEntry
GWCLQVNHLLYWALT

NAT1

66

P18440
WCAVHVQIAWQIYRH

FBRSL1

591

Q9HCM7
SVGYILWVCWVHHVT

AIG1

166

Q9NVV5
WNYRDALAVIWSHEC

ADPRM

256

Q3LIE5
LAAWLWAVLHYGLAH

DNHD1

3326

Q96M86
AHWVACVWFYIGQRE

KCNH3

371

Q9ULD8
VLHAHCCWEYVVQWN

RAB3GAP2

1011

Q9H2M9
AVIVHGAWWYASCYR

FCN3

246

O75636
LWVHLNCALWSTEVY

KMT2C

4426

Q8NEZ4
LIAHWLACIWYAIGN

KCNH7

561

Q9NS40
VRAIWIWICHHIEYD

KY

186

Q8NBH2
SILLWVGAFLCWIAY

ATP12A

116

P54707
TFALIAHWLACIWYA

KCNH2

556

Q12809
FGLVAHWLACIWYSI

KCNH5

356

Q8NCM2
HWLACIWYSIGDYEV

KCNH5

361

Q8NCM2
CTFALIAHWLACIWY

KCNH6

406

Q9H252
IAHWLACIWYAIGNV

KCNH6

411

Q9H252
WLQYEIAKVIWCLHT

NRDE2

736

Q9H7Z3
CLWKQYAHLEWLLGN

NRDE2

781

Q9H7Z3
LLAHWMACIWYVIGR

KCNH4

371

Q9UQ05
ALYTAHAQAWAQLWV

PGGHG

226

Q32M88
WHEIVNYICQVIFWI

P2RY12

186

Q9H244
LHCVSWALIFPCYWL

SMPD3

16

Q9NY59
WQYVHCLFLWCRVLS

NOC2L

406

Q9Y3T9
LYHVVGWTDWNLALN

GBA

411

P04062
WCQILLLVNHTDYRW

HTT

1836

P42858
CYSWGVCAAIWALVL

FFAR1

121

O14842
DYQLEGLNWLAHSWC

CHD2

486

O14647
GASWLLAHVLAWTYA

CYP4F2

26

P78329
IVGFLWSCWVLVGYA

BMP5

11

P22003
CQDWLEALHWYNTAL

EEF2K

631

O00418
LYFLWLGCVVLWAQG

FBN2

11

P35556
NVVYHAADLSLWWQV

SLC15A4

441

Q8N697
LWAQRLGHCHTYWAV

IRF3

281

Q14653
VLHLAWVACGYIIWQ

LXN

136

Q9BS40
FLDCHYNWELVIWCI

PHTF2

661

Q8N3S3
IHSLPCDYRANQWAW

TIGD6

241

Q17RP2
AAWICIVRYHQLRDW

TMEM150B

66

A6NC51
EALLCWYHIARAKAW

TIGD3

81

Q6B0B8
HSWILYVAAALWGVG

UNC93B1

431

Q9H1C4
WYIVGIVSWGQSCAL

TMPRSS11F

401

Q6ZWK6
LLYQVWWLQGHVEEC

TEX13C

86

A0A0J9YWL9
WGKIVAQYIHDQWVC

TARBP1

881

Q13395
LYAGLWTLCNHELCW

TMEM202

91

A6NGA9
LCNGYWLAWLIHVGE

TMEM254

61

Q8TBM7
VYVLFGVLWLAWSAC

TMEM87A

236

Q8NBN3
LWVHLNCALWSTEVY

KMT2D

5056

O14686