Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncopper ion binding

MUC2 SCO2 MOXD1

5.31e-0578193GO:0005507
GeneOntologyMolecularFunction1-phosphatidylinositol-3-kinase regulator activity

SOCS5 SOCS4

1.02e-0416192GO:0046935
GeneOntologyMolecularFunctionmolecular carrier activity

MYD88 SCO2 NUP214

1.40e-04108193GO:0140104
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

MYD88 RBBP8 LIG4 POLR3K N4BP1

2.76e-04645195GO:0140640
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

MYD88 RBBP8 LIG4

1.85e-03262193GO:0140097
GeneOntologyMolecularFunctiontransition metal ion binding

MUC2 SCO2 POLR3K MOXD1 TRIM67

4.28e-031189195GO:0046914
GeneOntologyBiologicalProcessnegative regulation of ERBB signaling pathway

PTPN12 SOCS5 SOCS4

5.05e-0637193GO:1901185
GeneOntologyBiologicalProcessregulation of ubiquitin-dependent protein catabolic process

N4BP1 SOCS5 SOCS4 TRIM67

2.19e-05185194GO:2000058
GeneOntologyBiologicalProcessregulation of epidermal growth factor receptor signaling pathway

PTPN12 SOCS5 SOCS4

6.46e-0586193GO:0042058
GeneOntologyBiologicalProcessregulation of proteolysis involved in protein catabolic process

N4BP1 SOCS5 SOCS4 TRIM67

7.64e-05255194GO:1903050
GeneOntologyBiologicalProcessregulation of catabolic process

MYD88 ZC3H14 KDR N4BP1 SOCS5 SOCS4 TRIM67

7.88e-051252197GO:0009894
GeneOntologyBiologicalProcessregulation of ERBB signaling pathway

PTPN12 SOCS5 SOCS4

8.16e-0593193GO:1901184
GeneOntologyBiologicalProcessnegative regulation of epidermal growth factor-activated receptor activity

SOCS5 SOCS4

8.38e-0515192GO:0007175
GeneOntologyBiologicalProcesspositive regulation of ubiquitin-dependent protein catabolic process

SOCS5 SOCS4 TRIM67

1.49e-04114193GO:2000060
GeneOntologyBiologicalProcessregulation of epidermal growth factor-activated receptor activity

SOCS5 SOCS4

1.84e-0422192GO:0007176
GeneOntologyBiologicalProcessregulation of proteasomal ubiquitin-dependent protein catabolic process

N4BP1 SOCS5 SOCS4

2.68e-04139193GO:0032434
GeneOntologyBiologicalProcessepidermal growth factor receptor signaling pathway

PTPN12 SOCS5 SOCS4

2.68e-04139193GO:0007173
GeneOntologyBiologicalProcesspositive regulation of proteolysis involved in protein catabolic process

SOCS5 SOCS4 TRIM67

3.22e-04148193GO:1903052
GeneOntologyBiologicalProcessnegative regulation of protein tyrosine kinase activity

SOCS5 SOCS4

3.44e-0430192GO:0061099
GeneOntologyBiologicalProcessnegative regulation of epidermal growth factor receptor signaling pathway

SOCS5 SOCS4

3.92e-0432192GO:0042059
GeneOntologyBiologicalProcessERBB signaling pathway

PTPN12 SOCS5 SOCS4

4.05e-04160193GO:0038127
GeneOntologyBiologicalProcessnegative regulation of signaling receptor activity

SOCS5 SOCS4

4.17e-0433192GO:2000272
GeneOntologyBiologicalProcesscellular response to low-density lipoprotein particle stimulus

MYD88 SOCS5

5.84e-0439192GO:0071404
GeneOntologyBiologicalProcessresponse to lipoprotein particle

MYD88 SOCS5

6.14e-0440192GO:0055094
GeneOntologyBiologicalProcesscellular response to lipoprotein particle stimulus

MYD88 SOCS5

7.10e-0443192GO:0071402
GeneOntologyBiologicalProcessadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

MYD88 C1S LIG4 SOCS5

7.37e-04462194GO:0002460
GeneOntologyBiologicalProcessregulation of proteasomal protein catabolic process

N4BP1 SOCS5 SOCS4

9.31e-04213193GO:0061136
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex

SOCS5 SOCS4

3.13e-0429192GO:0005942
GeneOntologyCellularComponentextrinsic component of membrane

MYD88 SOCS5 SOCS4

1.12e-03230193GO:0019898
GeneOntologyCellularComponenttransferase complex, transferring phosphorus-containing groups

POLR3K SOCS5 SOCS4

3.27e-03335193GO:0061695
HumanPhenoParaproteinemia

MYD88 LIG4

1.52e-053122HP:0031047
DomainSOCS

SOCS5 SOCS4

9.80e-072192PF12610
DomainSOCS4/SOCS5_dom

SOCS5 SOCS4

9.80e-072192IPR022252
DomainSOCS

SOCS5 SOCS4

1.84e-0420192SM00253
DomainSOCS_box

SOCS5 SOCS4

6.74e-0438192PF07525
DomainSOCS

SOCS5 SOCS4

7.10e-0439192PS50225
DomainSOCS_box

SOCS5 SOCS4

7.10e-0439192SM00969
DomainSOCS_box

SOCS5 SOCS4

7.10e-0439192IPR001496
DomainTRYPSIN_SER

CORIN C1S

3.72e-0390192IPR033116
DomainSH2

SOCS5 SOCS4

4.66e-03101192PF00017
DomainTRYPSIN_HIS

CORIN C1S

4.84e-03103192IPR018114
DomainTRYPSIN_SER

CORIN C1S

5.12e-03106192PS00135
DomainTRYPSIN_HIS

CORIN C1S

5.22e-03107192PS00134
DomainSH2

SOCS5 SOCS4

5.51e-03110192SM00252
DomainSH2

SOCS5 SOCS4

5.60e-03111192PS50001
DomainSH2

SOCS5 SOCS4

5.70e-03112192IPR000980
Domain-

SOCS5 SOCS4

5.70e-031121923.30.505.10
DomainPeptidase_S1A

CORIN C1S

5.80e-03113192IPR001314
DomainTRYPSIN_DOM

CORIN C1S

6.00e-03115192PS50240
DomainTryp_SPc

CORIN C1S

6.21e-03117192SM00020
DomainTrypsin

CORIN C1S

6.62e-03121192PF00089
DomainTrypsin_dom

CORIN C1S

6.62e-03121192IPR001254
DomainPeptidase_S1_PA

CORIN C1S

6.84e-03123192IPR009003
Pubmed

The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.

SOCS5 SOCS4

2.83e-07219222423360
Pubmed

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.

SOCS5 SOCS4

8.48e-07319228195529
Pubmed

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.

MYD88 KDR

1.70e-06419230639056
Pubmed

Long noncoding RNA TUSC7 inhibits cell proliferation, migration and invasion by regulating SOCS4 (SOCS5) expression through targeting miR-616 in endometrial carcinoma.

SOCS5 SOCS4

1.70e-06419231200002
Pubmed

H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.

RBBP8 LIG4

1.70e-06419221160476
Pubmed

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.

SOCS5 SOCS4

2.82e-06519215590694
Pubmed

The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression.

SOCS5 SOCS4

1.55e-051119219385048
Pubmed

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

SOCS5 SOCS4

2.20e-051319223990909
Pubmed

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.

MUC2 MYD88

2.96e-051519227339979
Pubmed

Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

RBBP8 STIL

3.38e-051619220301772
Pubmed

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.

MYD88 KDR

3.83e-051719235709757
Pubmed

Substrate specificities and identification of putative substrates of ATM kinase family members.

RBBP8 LIG4

8.42e-052519210608806
Pubmed

RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion.

SOCS5 SOCS4

8.42e-052519229361558
Pubmed

Polymorphisms in innate immunity genes and risk of childhood leukemia.

MYD88 C1S SOCS4

1.85e-0420619320438785
Pubmed

Risk of meningioma and common variation in genes related to innate immunity.

MYD88 C1S SOCS4

1.88e-0420719320406964
Pubmed

Common variation in genes related to innate immunity and risk of adult glioma.

MYD88 C1S SOCS4

1.90e-0420819319423540
Pubmed

The SOCS box: a tale of destruction and degradation.

SOCS5 SOCS4

2.29e-044119212076535
Pubmed

Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.

SOCS5 SOCS4

2.40e-044219224210661
Pubmed

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.

POLR3K STIL

3.98e-045419226288249
GeneFamilySH2 domain containing|Suppressors of cytokine signaling

SOCS5 SOCS4

2.05e-058162764
GeneFamilySH2 domain containing

SOCS5 SOCS4

3.52e-03101162741
CoexpressionGSE26343_UNSTIM_VS_LPS_STIM_NFAT5_KO_MACROPHAGE_DN

RBBP8 KDR N4BP1 PTPN12

1.17e-05200194M8643
CoexpressionWAMUNYOKOLI_OVARIAN_CANCER_LMP_DN

C1S KDR PTPN12 SOCS5

1.17e-05200194M10091
CoexpressionGSE1432_CTRL_VS_IFNG_24H_MICROGLIA_DN

MYD88 C1S SCO2 N4BP1

1.17e-05200194M3408
CoexpressionRUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP

MYD88 C1S SCO2 NUP214

1.92e-04411194M19971
CoexpressionGSE6092_B_BURGDOFERI_VS_B_BURGDORFERI_AND_IFNG_STIM_ENDOTHELIAL_CELL_DN

KDR N4BP1 PTPN12

2.85e-04180193M6717
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

ZC3H14 N4BP1 PTPN12 SOCS5 STIL

2.91e-04856195M4500
CoexpressionGSE29614_DAY3_VS_DAY7_TIV_FLU_VACCINE_PBMC_DN

LIG4 MOXD1 STIL

3.39e-04191193M4915
CoexpressionGSE360_L_MAJOR_VS_M_TUBERCULOSIS_MAC_UP

MUC2 RBBP8 NUP214

3.65e-04196193M5252
CoexpressionGSE17974_0H_VS_24H_IN_VITRO_ACT_CD4_TCELL_DN

RBBP8 SCO2 POLR3K

3.76e-04198193M4173
CoexpressionGSE46606_IRF4MID_VS_WT_CD40L_IL2_IL5_DAY1_STIMULATED_BCELL_DN

RBBP8 N4BP1 PTPN12

3.82e-04199193M9851
CoexpressionGSE41978_ID2_KO_VS_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_UP

MYD88 C1S SCO2

3.82e-04199193M9568
CoexpressionGSE13485_CTRL_VS_DAY7_YF17D_VACCINE_PBMC_DN

MYD88 RBBP8 SCO2

3.88e-04200193M3288
CoexpressionGSE37534_UNTREATED_VS_PIOGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_DN

MYD88 C1S SCO2

3.88e-04200193M8982
CoexpressionGSE8685_IL2_ACT_IL2_STARVED_VS_IL15_ACT_IL2_STARVED_CD4_TCELL_DN

ZC3H14 POLR3K NUP214

3.88e-04200193M332
CoexpressionGSE2405_0H_VS_24H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_DN

RBBP8 LIG4 STIL

3.88e-04200193M6193
CoexpressionGSE28237_FOLLICULAR_VS_LATE_GC_BCELL_DN

RBBP8 PTPN12 STIL

3.88e-04200193M4889
CoexpressionGSE40274_CTRL_VS_FOXP3_TRANSDUCED_ACTIVATED_CD4_TCELL_UP

RBBP8 POLR3K STIL

3.88e-04200193M9135
CoexpressionGSE1432_CTRL_VS_IFNG_6H_MICROGLIA_DN

C1S SCO2 LIG4

3.88e-04200193M3405
CoexpressionGSE5679_CTRL_VS_RARA_AGONIST_AM580_TREATED_DC_UP

RBBP8 POLR3K STIL

3.88e-04200193M6555
CoexpressionGSE10239_MEMORY_VS_KLRG1HIGH_EFF_CD8_TCELL_DN

ZC3H14 PTPN12 SOCS4

3.88e-04200193M3067
CoexpressionGSE1432_1H_VS_6H_IFNG_MICROGLIA_DN

C1S SCO2 LIG4

3.88e-04200193M3411
ToppCellLPS-IL1RA|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RBBP8 KDR N4BP1

6.21e-05184193c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORIN MOXD1 TRIM67

6.42e-05186193cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCelldroplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORIN MOXD1 TRIM67

6.42e-05186193b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CORIN MOXD1 TRIM67

6.52e-051871938bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CORIN MOXD1 TRIM67

6.52e-051871933cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

CORIN RBBP8 STIL

6.62e-05188193f5102e8d95506c25c675094b86162a6a50087b64
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C1S MOXD1 PTPN12

7.27e-05194193f44394c8a6f86483063f2f5722f003a8a0a70254
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CORIN MOXD1 TRIM67

7.38e-05195193c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CORIN MOXD1 TRIM67

7.38e-05195193ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CORIN C1S MOXD1

7.38e-0519519351db90e7611f7d69980878c046505ff34212079b
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CORIN C1S MOXD1

7.49e-05196193e7bfd4fb400ae0c473131d0fa306c26be08a6d03
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CORIN C1S MOXD1

7.49e-0519619382fad623212d986a7fca3496faf3f8c8f5b83a11
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CORIN C1S MOXD1

7.49e-0519619385e5046f774537684e1443c0fc147d562b7068d0
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CORIN C1S MOXD1

7.84e-05199193fb580e9321ddf97c73b2e356cd82523db74a38a2
ToppCellsevere-T/NK_proliferative|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RBBP8 POLR3K STIL

7.96e-052001939d6e7e2d6cfa8c96bbb5c187815df96ecaa5475c
ToppCellParenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_peribronchial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CORIN C1S MOXD1

7.96e-05200193efdf7066b7dd43e35dbc0d2719b75f250cf54af2
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CORIN C1S MOXD1

7.96e-052001938ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCellBiopsy_IPF-Mesenchymal-Myofibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

CORIN C1S MOXD1

7.96e-05200193c2c6f687c49ba790174b27c7b8b084af30b34c86
ToppCellsevere_influenza-B_cell|World / disease group, cell group and cell class (v2)

RBBP8 SOCS5

6.05e-04861927b595bcba4bcb72b7de7c06e19f690f0c739c529
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Mucinous-6|TCGA-Stomach / Sample_Type by Project: Shred V9

MUC2 SOCS4

7.68e-0497192489f5e12eb67b1850f1f2d7d4b229df1f4ceefe3
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1S STIL

8.82e-04104192a3d061170fe49d023ac31dbaeb2b5d2347988078
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1S STIL

8.82e-04104192fdf4599de8cd4ccf1bd7ede4e7af63d69c108b43
ToppCelldroplet-Lung-30m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l14|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOCS4 STIL

9.16e-04106192ede8407ad253080d1fa2a6e2aacf549ce220309a
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CORIN MOXD1

1.29e-0312619284dce108561d4b745d19250c2ac0667d9e4ea17d
ToppCellsevere_influenza-B_cell|severe_influenza / disease group, cell group and cell class (v2)

RBBP8 SOCS5

1.33e-0312819292b250186d6bb08ce4f2f5cc4fb93928f6b92d3a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related-Oligodendrocyte/OPC|GW26 / Sample Type, Dataset, Time_group, and Cell type.

RBBP8 MOXD1

1.52e-031371928ce463d1d74ac0ce80b812217d6bd76a788f14d2
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related|GW26 / Sample Type, Dataset, Time_group, and Cell type.

RBBP8 MOXD1

1.52e-03137192264d5e06c37d1a9ef7748091b67d2a5aa803096e
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-2|TCGA-Brain / Sample_Type by Project: Shred V9

MUC2 TRIM67

1.57e-031391926f6c64eaa1ce84e0aa9a0caa9c4d9bf7afe626df
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SCO2 STIL

1.63e-03142192e160f35b3c18e77c4107fe96db5f56227c91785e
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RBBP8 SOCS4

1.70e-0314519247a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KDR SOCS5

1.87e-031521920652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCellCOVID-19_Mild-PLT_0|World / Disease Group and Platelet Clusters

SCO2 MOXD1

1.87e-03152192d49f7c0681500fc4d93818d47e8e8afb726c23d9
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MUC2 MOXD1

1.92e-03154192e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RBBP8 KDR

1.92e-03154192b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TTLL9 TRIM67

1.94e-03155192105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCelldroplet-Heart-nan-3m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR NUP214

1.99e-03157192d85a2f56ae313baa9738e81d2756ce1fe1ba50db
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CORIN N4BP1

2.14e-03163192130c84bca3f72ab7d1a4fee2990c3d01600318ed
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S MOXD1

2.17e-0316419201a7c335897128d3478b8b9b44fb461cab493084
ToppCellCOVID-19_Mild-PLT_0|COVID-19_Mild / Disease Group and Platelet Clusters

SCO2 MOXD1

2.19e-03165192083a14d3b0162cee4e79f7398b8fb739582b39ff
ToppCelldroplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1S STIL

2.19e-0316519296f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C1S STIL

2.22e-0316619249103b75c3e08656c5774f56fd00d7bd53eefcfb
ToppCell5'-Adult-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MUC2 SOCS4

2.22e-031661920b4e1d879c61be9d18d7aac51e5115f103f51209
ToppCellfacs-Skin-Anagen-24m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1S MOXD1

2.25e-0316719278909f685ccd1321064eb0887caf9263e0e54879
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR SOCS5

2.27e-03168192c7021748003e5949f7caf7b3291c5bad294948c1
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MOXD1 STIL

2.27e-0316819208f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

C1S MOXD1

2.30e-031691928ebe9a88111c53a09c25a7b6a164a0a17880458d
ToppCellFrontal_cortex-Neuronal-Inhibitory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SOCS5 TRIM67

2.30e-0316919278eb70dd916724e476eabccf18fb7fcec4210308
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CORIN C1S

2.30e-03169192335619507857383c3b0b507cdf05d786ed59e585
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MUC2 MOXD1

2.33e-03170192af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCell10x5'-Liver-Lymphocytic_B-ABC_aged-B_memory|Liver / Manually curated celltypes from each tissue

TTLL9 MOXD1

2.35e-03171192eb47f4a09a630ed14a0898377039ed50ef7cc292
ToppCellAT1-AT2_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

C1S LIG4

2.35e-031711920b9912f07393aca889db72b40da08e0bc9bc1e8c
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KDR MOXD1

2.35e-031711923112d15f2a28cf4a71992db4971d960716dc1264
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S MOXD1

2.38e-031721921ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S MOXD1

2.38e-03172192ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCell10x5'-Lung-Lymphocytic_B-Memory_B_cells|Lung / Manually curated celltypes from each tissue

MUC2 MOXD1

2.38e-031721922cb2dc7cfd6db5a98a393b1a84c23abf3d692a53
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MUC2 MOXD1

2.38e-031721929a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCell-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

C1S MOXD1

2.41e-0317319288be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MOXD1 TRIM67

2.41e-03173192922356a5b4c84607318ac24d7caa2e235b72b066
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S MOXD1

2.44e-031741929c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S MOXD1

2.44e-03174192bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-Alox5+_Lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIG4 MOXD1

2.44e-03174192a8bd1fa08bf061a627529a38e5a23a68b6d80697
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MOXD1 STIL

2.44e-031741926c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1S MOXD1

2.44e-0317419295464817adef5ad2038bbf542f315756b7ad862e
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIG4 MOXD1

2.44e-031741927f8f6a15a823809effd37c1a5b09ef19b6d67755
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MOXD1 TRIM67

2.44e-03174192412ccc099028a372b9d953363984c2da54b2187f
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR MOXD1

2.46e-031751922e54961846c65b185d9bd6e305dd81205579d890
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MOXD1 STIL

2.46e-03175192553e68e8b439a2293efb969e1e2aa017ceb80daf
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MOXD1 STIL

2.46e-0317519216d4e97271df1db9a0d167fc82a90d84d20dd1f2
ToppCellfacs-Skin-Anagen-24m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1S MOXD1

2.46e-031751925552ff1e13f931c8cd7780726c90b5609497a648
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MOXD1 STIL

2.46e-03175192289d2aa7164bc02b1876b99f2fb67baa8e030c4e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR MOXD1

2.46e-03175192efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCell10x5'-blood-Lymphocytic_B_plasma-Plasmablasts|blood / Manually curated celltypes from each tissue

MOXD1 STIL

2.46e-031751922e048bf7961c3d86b6e12a1ebae3b3f2359af457
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RBBP8 STIL

2.46e-0317519289bf89466191da14896ed8928027f5b911436c22
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

C1S MOXD1

2.49e-03176192510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S MOXD1

2.49e-03176192fcf324e6402819683f95e0dd94bf1f777c7f4c76
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CORIN MOXD1

2.49e-031761929bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

C1S MOXD1

2.49e-031761922e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CORIN MOXD1

2.49e-031761923f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

C1S MOXD1

2.49e-03176192f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCelltumor_Lung-B_lymphocytes-Plasma_cells|B_lymphocytes / Location, Cell class and cell subclass

CORIN KDR

2.49e-03176192683022c3400e951b26c2b49394dfd3cc415276fe
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR N4BP1

2.52e-03177192ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR N4BP1

2.52e-03177192f471f7747d6e8db7546899019af9508f48a14f89
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_12|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TTLL9 RBBP8

2.52e-03177192cbedac0bddb8fc330a464815c905928c553b0fc0
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR N4BP1

2.52e-03177192cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CORIN C1S

2.52e-0317719230f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

C1S MOXD1

2.52e-031771927617270f49cd6b7ba66db72d20560cee985012b2
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

C1S MOXD1

2.52e-031771928220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RBBP8 C1S

2.52e-031771929e65b39fd797b6ce204b6480415810d1923acee5
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-cDC1|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYD88 TTLL9

2.52e-03177192345cebc19f93970a9a46be139208b300081f5493
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1S MOXD1

2.55e-0317819209475e522dc1b8cf9ff1c25de5d1e3082b162948
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1S MOXD1

2.55e-0317819235de8f791b0e78a6caf52ff095f05e204a59e828
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR N4BP1

2.55e-0317819201dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

CORIN KDR

2.55e-03178192edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KDR STIL

2.55e-03178192462111b61f37338f97ac7dc6c7da1d4316b54445
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1S MOXD1

2.55e-03178192000d25f3f13cc76cf39c46c312c6fafc2ea4f368
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S MOXD1

2.55e-0317819278a0c6340001a77f5b2d890b6263f574af2e72da
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_12|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TTLL9 RBBP8

2.55e-0317819204bfecf5ea5d85c843e48d08718b5d69e7bf834e
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZC3H14 MOXD1

2.57e-031791925be883d7d0be3180bb9844e4a757f0dd247294e4
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

MOXD1 STIL

2.57e-03179192021d782134126c6f7dce6b6ea50cc54bdaa39987
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S MOXD1

2.57e-0317919268ccfe66474d049a926afc21bffa231446becc69
Diseasecolorectal cancer (is_implicated_in)

MYD88 LIG4 KDR PTPN12

9.94e-07121194DOID:9256 (is_implicated_in)
DiseaseSeckel syndrome

RBBP8 LIG4

9.00e-0522192C0265202
DiseasePrimary microcephaly

RBBP8 STIL

9.00e-0522192C0431350
DiseaseLymphoma

MYD88 LIG4

3.02e-0440192C0024299
Diseasecolitis (biomarker_via_orthology)

MUC2 KDR

3.33e-0442192DOID:0060180 (biomarker_via_orthology)
DiseasePrecursor T-Cell Lymphoblastic Leukemia-Lymphoma

NUP214 STIL

5.31e-0453192C1961099
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

LIG4 NUP214

7.03e-0461192C1961102
DiseaseMicrocephaly

LIG4 NUP214

8.47e-0467192C0025958
Diseaseeosinophil percentage of leukocytes

MUC2 RBBP8 C1S N4BP1

1.16e-03746194EFO_0007991
DiseaseReperfusion Injury

MYD88 KDR

1.49e-0389192C0035126
DiseasePancreatic Neoplasm

RBBP8 KDR

1.87e-03100192C0030297

Protein segments in the cluster

PeptideGeneStartEntry
HTCKECEIYYADMPA

RBBP8

811

Q99708
VDPKPFYEACVHDSC

MUC2

1066

Q02817
HMPERFDAFICYCPS

MYD88

156

Q99836
EKHPEIFVNFMEPCY

NUP214

281

P35658
MCPSTKEHFAREYDC

LIG4

746

P49917
CSCPPEYFLHDDMKN

C1S

156

P09871
LMPDEYVEECSPSHF

CORIN

571

Q9Y5Q5
ICDGFPDCPDYMDEK

CORIN

636

Q9Y5Q5
MYFGFTHCPDICPDE

SCO2

126

O43819
LEHYKDPSSCMFFEP

SOCS5

456

O75159
IHYEMCIECPPTFSD

PTPN12

731

Q05209
LEHYKDPSACMFFEP

SOCS4

361

Q8WXH5
MTHKEPEFYECFPCD

STIL

306

Q15468
PTCPEHEMENYSMYC

TRIM67

301

Q6ZTA4
ECYHPNMPDAFLTCE

MOXD1

256

Q6UVY6
AESCPKCEHPRAYFM

POLR3K

66

Q9Y2Y1
CDFFPKTFEMPCEYH

TTLL9

136

Q3SXZ7
CMEEEEVCDPKFHYD

KDR

1201

P35968
MECPFYHPKHCRFNT

ZC3H14

691

Q6PJT7
ECYPKDMHCIFVGAE

N4BP1

81

O75113