Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	chromatin remodeling	RLF RSBN1 ZNF93 SETD2 C6orf89 TRIM28 SUPT16H ARID1A PRDM16 SPTY2D1 DNMT1	1.88e-06	741	52	11	GO:0006338
GeneOntologyBiologicalProcess	chromatin organization	RLF RSBN1 ZNF93 SETD2 C6orf89 TRIM28 SUPT16H ARID1A PRDM16 SPTY2D1 DNMT1	1.15e-05	896	52	11	GO:0006325
GeneOntologyBiologicalProcess	protein-DNA complex organization	RLF RSBN1 ZNF93 SETD2 C6orf89 TRIM28 SUPT16H ARID1A PRDM16 SPTY2D1 DNMT1	3.16e-05	999	52	11	GO:0071824
GeneOntologyBiologicalProcess	negative regulation of gene expression, epigenetic	RLF ZNF93 TRIM28 SPTY2D1 DNMT1	1.57e-04	203	52	5	GO:0045814
GeneOntologyBiologicalProcess	epigenetic regulation of gene expression	RLF ZNF93 TRIM28 ARID1A SPTY2D1 DNMT1	1.76e-04	330	52	6	GO:0040029
GeneOntologyBiologicalProcess	transposable element silencing	ZNF729 ZNF93 ZNF99	2.13e-04	46	52	3	GO:0010526
GeneOntologyBiologicalProcess	retrotransposition	ZNF729 ZNF93 ZNF99	2.41e-04	48	52	3	GO:0032197
GeneOntologyBiologicalProcess	transposition	ZNF729 ZNF93 ZNF99	2.72e-04	50	52	3	GO:0032196
GeneOntologyBiologicalProcess	axo-dendritic protein transport	MAP1A MYO5A	3.38e-04	11	52	2	GO:0099640
GeneOntologyBiologicalProcess	regulation of mRNA export from nucleus	SETD2 NSUN2	3.38e-04	11	52	2	GO:0010793
GeneOntologyBiologicalProcess	nucleosome organization	SETD2 SUPT16H ARID1A SPTY2D1	4.51e-04	142	52	4	GO:0034728
GeneOntologyBiologicalProcess	regulation of ribonucleoprotein complex localization	SETD2 NSUN2	4.78e-04	13	52	2	GO:2000197
GeneOntologyBiologicalProcess	negative regulation of synaptic transmission, glutamatergic	MYO5A GRIK3	4.78e-04	13	52	2	GO:0051967
HumanPheno	Abnormal eating behavior	SETD2 ALMS1 SUPT16H RFX7 ARID1A PRDM16	4.64e-06	128	19	6	HP:0100738
HumanPheno	Polyphagia	SETD2 ALMS1 SUPT16H RFX7 PRDM16	7.27e-06	78	19	5	HP:0002591
HumanPheno	Autistic behavior	SETD2 ALMS1 TNPO2 SUPT16H MED13L RFX7 ARID1A NSUN2 PRDM16 TBX2	4.86e-05	678	19	10	HP:0000729
HumanPheno	Diagnostic behavioral phenotype	SETD2 ALMS1 TNPO2 SUPT16H MED13L RFX7 ARID1A NSUN2 PRDM16 TBX2	1.14e-04	747	19	10	HP:0025783
HumanPheno	Delayed speech and language development	SETD2 REPS1 ALMS1 TNPO2 COBLL1 SUPT16H MED13L RFX7 ARID1A NSUN2 PRDM16 DNAH9	1.32e-04	1123	19	12	HP:0000750
HumanPheno	Language impairment	SETD2 REPS1 ALMS1 TNPO2 COBLL1 SUPT16H MED13L RFX7 ARID1A NSUN2 PRDM16 DNAH9	2.15e-04	1178	19	12	HP:0002463
HumanPheno	Disinhibition	SETD2 TNPO2 SUPT16H MED13L RFX7 ARID1A NSUN2 PRDM16 DNMT1 TBX2	2.22e-04	807	19	10	HP:0000734
HumanPheno	Inappropriate behavior	SETD2 TNPO2 SUPT16H MED13L RFX7 ARID1A NSUN2 PRDM16 DNMT1 TBX2	2.22e-04	807	19	10	HP:0000719
HumanPheno	Abnormal response to social norms	SETD2 TNPO2 SUPT16H MED13L RFX7 ARID1A NSUN2 PRDM16 DNMT1 TBX2	2.22e-04	807	19	10	HP:5200123
HumanPheno	Social disinhibition	SETD2 TNPO2 SUPT16H MED13L RFX7 ARID1A NSUN2 PRDM16 DNMT1 TBX2	2.22e-04	807	19	10	HP:5200029
HumanPheno	Broad nasal tip	SETD2 SUPT16H RFX7 ARID1A TBX2	2.27e-04	159	19	5	HP:0000455
HumanPheno	Wide nasal bridge	SETD2 TNPO2 PEX3 SUPT16H MED13L RFX7 NSUN2 PRDM16	2.59e-04	508	19	8	HP:0000431
HumanPheno	Reduced impulse control	SETD2 ALMS1 TNPO2 SUPT16H MED13L RFX7 ARID1A NSUN2 PRDM16 DNMT1 TBX2	3.39e-04	1032	19	11	HP:5200045
MousePheno	absent mesoderm	TRIM28 EIF4G2 GNPNAT1 ARID1A	3.87e-05	67	40	4	MP:0001683
Domain	RSBN1	RSBN1 RSBN1L	7.60e-06	2	52	2	IPR026306
Domain	-	ZNF729 CBLL1 RLF ZNF93 ZNF257 ZNF516 ZNF552 ZNF99 PRDM16	9.54e-05	679	52	9	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 CBLL1 RLF ZNF93 ZNF257 ZNF516 ZNF552 ZNF99 PRDM16	1.13e-04	694	52	9	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF729 CBLL1 RLF ZNF93 ZNF257 ZNF516 ZNF552 ZNF99 PRDM16	2.58e-04	775	52	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF729 CBLL1 RLF ZNF93 ZNF257 ZNF516 ZNF552 ZNF99 PRDM16	2.63e-04	777	52	9	PS00028
Domain	Znf_C2H2-like	ZNF729 CBLL1 RLF ZNF93 ZNF257 ZNF516 ZNF552 ZNF99 PRDM16	3.14e-04	796	52	9	IPR015880
Domain	ZnF_C2H2	ZNF729 CBLL1 RLF ZNF93 ZNF257 ZNF516 ZNF552 ZNF99 PRDM16	3.51e-04	808	52	9	SM00355
Domain	zf-C2H2	ZNF729 RLF ZNF93 ZNF257 ZNF516 ZNF552 ZNF99 PRDM16	6.12e-04	693	52	8	PF00096
Domain	PDZ	AHNAK ERBIN PRX AHNAK2	6.36e-04	141	52	4	PF00595
Domain	PDZ	AHNAK ERBIN PRX AHNAK2	7.63e-04	148	52	4	SM00228
Domain	-	AHNAK ERBIN PRX AHNAK2	8.02e-04	150	52	4	2.30.42.10
Domain	PDZ	AHNAK ERBIN PRX AHNAK2	8.22e-04	151	52	4	PS50106
Domain	PDZ	AHNAK ERBIN PRX AHNAK2	8.43e-04	152	52	4	IPR001478
Domain	Znf_C2H2	ZNF729 RLF ZNF93 ZNF257 ZNF516 ZNF552 ZNF99 PRDM16	1.61e-03	805	52	8	IPR007087
Domain	KRAB	ZNF729 ZNF93 ZNF257 ZNF552 ZNF99	3.13e-03	358	52	5	PS50805
Domain	KRAB	ZNF729 ZNF93 ZNF257 ZNF552 ZNF99	3.13e-03	358	52	5	PF01352
Domain	KRAB	ZNF729 ZNF93 ZNF257 ZNF552 ZNF99	3.56e-03	369	52	5	SM00349
Domain	KRAB	ZNF729 ZNF93 ZNF257 ZNF552 ZNF99	3.60e-03	370	52	5	IPR001909
Domain	SET	SETD2 PRDM16	7.28e-03	46	52	2	SM00317
Domain	SET_dom	SETD2 PRDM16	8.55e-03	50	52	2	IPR001214
Domain	SET	SETD2 PRDM16	8.55e-03	50	52	2	PS50280
Domain	p53-like_TF_DNA-bd	FUT3 TBX2	9.57e-03	53	52	2	IPR008967
Domain	zf-C2H2_6	ZNF729 ZNF93 ZNF99 PRDM16	1.13e-02	314	52	4	PF13912
Pathway	BIOCARTA_VDR_PATHWAY	SNW1 SUPT16H ARID1A	2.91e-05	22	39	3	MM1370
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SETD2 SNW1 REPS1 ALMS1 MAP1A TRIM28 AHNAK EIF4G2 COPG2 NSUN2 ERBIN RSBN1L DNMT1 AHNAK2	8.38e-11	934	53	14	33916271
Pubmed	Self-regulated alternative splicing at the AHNAK locus.	AHNAK PRX AHNAK2	3.34e-09	3	53	3	21940993
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SETD2 SNW1 REPS1 ALMS1 TRIM28 AHNAK ARID1A ERBIN RSBN1L DNMT1	9.39e-09	549	53	10	38280479
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RLF SNW1 MYO5A TRIM28 AHNAK EIF4G2 SUPT16H GNPNAT1 ARID1A NSUN2 ERBIN DNMT1 AHNAK2 NGDN	9.87e-09	1353	53	14	29467282
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CBLL1 RSBN1 SETD2 SNW1 TRIM28 AHNAK EIF4G2 SUPT16H COPG2 ARID1A RSBN1L DNMT1	1.61e-08	954	53	12	36373674
Pubmed	Interaction network of human early embryonic transcription factors.	RLF ALMS1 TNPO2 ZNF516 RFX7 ARID1A PRDM16 TBX2	5.93e-08	351	53	8	38297188
Pubmed	Human transcription factor protein interaction networks.	RLF RSBN1 FAT1 SNW1 ALMS1 MYO5A TNPO2 ZNF516 RFX7 ARID1A NSUN2 PRDM16 ERBIN	1.63e-07	1429	53	13	35140242
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CBLL1 SETD2 SNW1 TRIM28 AHNAK EIF4G2 SUPT16H RFX7 ARID1A SPTY2D1 DNMT1 NGDN	4.35e-07	1294	53	12	30804502
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CBLL1 SNW1 ALMS1 TRIM28 AHNAK SUPT16H ARID1A DNMT1	5.37e-07	469	53	8	27634302
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 TRIM28 ZNF99	5.47e-07	11	53	3	15469996
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	FAT1 TRIM28 AHNAK SUPT16H ARID1A DNMT1 AHNAK2	7.17e-07	332	53	7	37433992
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	SNW1 TRIM28 AHNAK EIF4G2 NSUN2 DNMT1 AHNAK2	7.17e-07	332	53	7	32786267
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SECISBP2L CEP68 SETD2 ALMS1 COBLL1 NELFB PRDM16 PRX	7.80e-07	493	53	8	15368895
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	RSBN1 SETD2 FAT1 ALMS1 MAP1A TRIM28 SUPT16H ARID1A PRDM16 RSBN1L TBX2	7.83e-07	1116	53	11	31753913
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SECISBP2L RSBN1 SNW1 REPS1 AHNAK COBLL1 SUPT16H NSUN2 SPTY2D1 RSBN1L DNMT1 NGDN	8.00e-07	1371	53	12	36244648
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 TRIM28 ZNF99	9.45e-07	13	53	3	19850934
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF93 ZNF99	1.50e-06	15	53	3	15885501
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CBLL1 RSBN1 SETD2 REPS1 MYO5A EIF4G2 COPG2 ERBIN SPTY2D1 RSBN1L TBX2 NGDN	2.00e-06	1497	53	12	31527615
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RSBN1 SNW1 MYO5A TRIM28 SUPT16H NSUN2 SPTY2D1 DNMT1 NGDN	2.01e-06	759	53	9	35915203
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	SNW1 TRIM28 AHNAK SUPT16H NSUN2 ERBIN SPTY2D1 RSBN1L DNMT1 NGDN	2.13e-06	989	53	10	36424410
Pubmed	The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.	AHNAK AHNAK2	2.28e-06	2	53	2	15007166
Pubmed	AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness.	AHNAK AHNAK2	2.28e-06	2	53	2	20833135
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SETD2 TRIM28 ZNF516 EIF4G2 NELFB RFX7 NSUN2 ERBIN DNMT1	2.36e-06	774	53	9	15302935
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	MYO5A AHNAK EIF4G2 NELFB COPG2 NSUN2 DNMT1	2.43e-06	399	53	7	37536630
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	SETD2 SNW1 TRIM28 AHNAK EIF4G2 SUPT16H NELFB MED13L NSUN2 DNMT1	2.65e-06	1014	53	10	32416067
Pubmed	An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.	RLF TRIM28 DNMT1	2.68e-06	18	53	3	24025402
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	TRIM28 ARID1A DNMT1	2.68e-06	18	53	3	28068325
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	CBLL1 APEX2 TRIM28 ARID1A DNMT1	4.24e-06	157	53	5	30686591
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	SNW1 REPS1 MAP1A TRIM28 AHNAK EIF4G2 AHNAK2	4.90e-06	444	53	7	34795231
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF729 ZNF93 ZNF257 TRIM28 EIF4G2 COPG2 NSUN2	5.42e-06	451	53	7	36168627
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	RLF SNW1 TNPO2 ZNF516 EIF4G2 NELFB MED13L ARID1A NSUN2 DNMT1	5.58e-06	1103	53	10	34189442
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	RLF ALMS1 ZNF257 AHNAK ZNF516 SUPT16H MED13L ERBIN	5.69e-06	645	53	8	25281560
Pubmed	Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.	ZNF93 TRIM28	6.83e-06	3	53	2	31289231
Pubmed	Structure and functional mapping of the KRAB-KAP1 repressor complex.	ZNF93 TRIM28	6.83e-06	3	53	2	36341546
Pubmed	Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.	ZNF516 PRDM16	6.83e-06	3	53	2	25578880
Pubmed	An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.	ZNF93 TRIM28	6.83e-06	3	53	2	25274305
Pubmed	Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise.	TRIM28 DNMT1	6.83e-06	3	53	2	21092094
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	SNW1 TRIM28 AHNAK SUPT16H NGDN	1.02e-05	188	53	5	29721183
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF93 ZNF99	1.19e-05	29	53	3	14563677
Pubmed	AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.	AHNAK AHNAK2	1.36e-05	4	53	2	17185750
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CBLL1 SNW1 MYO5A TRIM28 ZNF516 SUPT16H GRIK3 ERBIN DNMT1	1.37e-05	963	53	9	28671696
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SNW1 REPS1 TRIM28 EIF4G2 COPG2 MED13L RFX7 ARID1A NSUN2 ERBIN	1.62e-05	1247	53	10	27684187
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CBLL1 SNW1 MYO5A TRIM28 AHNAK SUPT16H NSUN2 RSBN1L DNMT1 NGDN	1.74e-05	1257	53	10	36526897
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CEP68 MYO5A TNPO2 PEX3 COPG2 SPTY2D1 DNMT1 NGDN	1.76e-05	754	53	8	33060197
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	AHNAK EIF4G2 COPG2 ERBIN AHNAK2	1.99e-05	216	53	5	31519766
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	REPS1 MYO5A ZRSR2 TNPO2 EIF4G2 MED13L ARID1A NSUN2 RSBN1L DNMT1	2.10e-05	1285	53	10	35914814
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SNW1 TRIM28 SUPT16H ARID1A NSUN2	2.17e-05	220	53	5	35785414
Pubmed	Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma.	SETD2 ARID1A	2.27e-05	5	53	2	28202515
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CEP68 ALMS1 MED13L PRDM16 ERBIN	2.42e-05	225	53	5	12168954
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	RSBN1 SNW1 TRIM28 AHNAK SUPT16H COPG2 NSUN2 RSBN1L DNMT1 NGDN	2.61e-05	1318	53	10	30463901
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	SNW1 REPS1 MYO5A COBLL1 SUPT16H	2.68e-05	230	53	5	35449600
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SECISBP2L SNW1 MYO5A TRIM28 EIF4G2 SUPT16H NSUN2 NGDN	2.86e-05	807	53	8	22681889
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF729 ZNF93 TRIM28 ZNF516 ARID1A ZNF99 PRDM16 DNMT1	2.88e-05	808	53	8	20412781
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MYO5A AHNAK COBLL1 SUPT16H PRDM16	2.91e-05	234	53	5	36243803
Pubmed	Deubiquitination of FBP1 by USP7 blocks FBP1-DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors.	TRIM28 DNMT1	3.40e-05	6	53	2	34854226
Pubmed	In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions.	TRIM28 DNMT1	3.40e-05	6	53	2	22055183
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	EIF4G2 ARID1A DNAH9 AHNAK2	3.81e-05	123	53	4	26912792
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FAT1 REPS1 TRIM28 AHNAK ZNF516 MED13L ARID1A PRDM16 AHNAK2	4.02e-05	1105	53	9	35748872
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SNW1 TRIM28 AHNAK SUPT16H SPTY2D1	4.07e-05	251	53	5	31076518
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	SNW1 AHNAK EIF4G2 COPG2 AHNAK2	4.47e-05	256	53	5	33397691
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ALMS1 AHNAK COBLL1 NELFB RFX7 ERBIN DNMT1 AHNAK2	4.52e-05	861	53	8	36931259
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	TRIM28 AHNAK ARID1A DNMT1 AHNAK2	4.72e-05	259	53	5	31162944
Pubmed	The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration.	ZNF93 TRIM28	4.76e-05	7	53	2	22801370
Pubmed	Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways.	SNW1 APEX2	4.76e-05	7	53	2	12650714
Pubmed	A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development.	RLF TRIM28	4.76e-05	7	53	2	19099580
Pubmed	SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.	AHNAK AHNAK2	4.76e-05	7	53	2	23415230
Pubmed	Topoisomerase II regulates the maintenance of DNA methylation.	SUPT16H DNMT1	4.76e-05	7	53	2	25451918
Pubmed	Integrated Proteomics-Based Physical and Functional Mapping of AXL Kinase Signaling Pathways and Inhibitors Define Its Role in Cell Migration.	AHNAK COPG2 ERBIN	4.84e-05	46	53	3	35022314
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	SNW1 TRIM28 EIF4G2 SUPT16H NSUN2 DNMT1 NGDN	5.17e-05	641	53	7	36057605
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	REPS1 TRIM28 TNPO2 AHNAK EIF4G2 SUPT16H COPG2 NSUN2 ERBIN AHNAK2	5.50e-05	1440	53	10	30833792
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SNW1 MYO5A AHNAK COPG2 ARID1A NSUN2 DNMT1	5.80e-05	653	53	7	22586326
Pubmed	Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.	MYO5A PEX3 NSUN2	6.23e-05	50	53	3	24721909
Pubmed	Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription.	SUPT16H ARID1A	6.34e-05	8	53	2	20599239
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	SETD2 TRIM28 NELFB MED13L ARID1A NSUN2	6.46e-05	453	53	6	29656893
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	SNW1 TRIM28 SUPT16H RSBN1L DNMT1	7.18e-05	283	53	5	30585729
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	SNW1 AHNAK EIF4G2 NSUN2 AHNAK2	9.15e-05	298	53	5	30737378
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	MYO5A AHNAK COPG2 AHNAK2	9.61e-05	156	53	4	30409884
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	REPS1 TRIM28 AHNAK COBLL1 EIF4G2 COPG2 ERBIN	9.61e-05	708	53	7	39231216
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 ZNF99	1.02e-04	10	53	2	18588511
Pubmed	A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.	TRIM28 DNMT1	1.24e-04	11	53	2	24623306
Pubmed	Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.	SNW1 SUPT16H	1.24e-04	11	53	2	15546612
Pubmed	Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.	ARID1A ERBIN	1.24e-04	11	53	2	18003620
Pubmed	A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells.	AHNAK PRX	1.24e-04	11	53	2	14625392
Pubmed	Genetic loci influencing kidney function and chronic kidney disease.	ALMS1 TBX2	1.24e-04	11	53	2	20383145
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	SNW1 SUPT16H MED13L ARID1A	1.25e-04	167	53	4	20362541
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	TRIM28 COPG2 NSUN2	1.30e-04	64	53	3	26511642
Pubmed	New loci associated with kidney function and chronic kidney disease.	ALMS1 RSBN1L TBX2	1.43e-04	66	53	3	20383146
Pubmed	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.	TRIM28 SUPT16H	1.49e-04	12	53	2	30479348
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	SETD2 AHNAK ZNF516 SUPT16H	1.56e-04	177	53	4	26206133
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	TRIM28 TNPO2 SUPT16H NELFB ARID1A DNMT1	1.57e-04	533	53	6	30554943
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF93 ZNF257 TRIM28 ZNF552	1.70e-04	181	53	4	37372979
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	FAT1 AHNAK NELFB COPG2 ERBIN SPTY2D1 DNMT1	1.71e-04	777	53	7	35844135
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	RSBN1 SUPT16H ARID1A ERBIN RSBN1L	1.72e-04	341	53	5	32971831
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	SNW1 AHNAK EIF4G2 SUPT16H ARID1A NSUN2 ERBIN DNMT1 AHNAK2	2.03e-04	1367	53	9	32687490
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	AHNAK COBLL1 EIF4G2 COPG2 ERBIN NGDN	2.15e-04	565	53	6	25468996
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CBLL1 SETD2 SNW1 MAP1A ZRSR2 TRIM28 SUPT16H ARID1A	2.19e-04	1082	53	8	38697112
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	SECISBP2L CBLL1 SNW1 SUPT16H ERBIN	2.23e-04	361	53	5	30344098
Pubmed	Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.	TRIM28 DNMT1	2.36e-04	15	53	2	27030811
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYO5A AHNAK SUPT16H DNMT1	2.59e-04	202	53	4	33005030
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	SNW1 TRIM28 AHNAK EIF4G2 SUPT16H NELFB NSUN2 DNMT1 AHNAK2	2.62e-04	1415	53	9	28515276
Interaction	NAA40 interactions	SETD2 SNW1 REPS1 ALMS1 MAP1A TRIM28 AHNAK EIF4G2 SUPT16H COPG2 NSUN2 ERBIN RSBN1L DNMT1 AHNAK2	1.45e-08	978	52	15	int:NAA40
Interaction	H3C1 interactions	RLF RSBN1 SETD2 SNW1 ZNF257 TRIM28 AHNAK COBLL1 SUPT16H NELFB PRDM16 DNAH9 RSBN1L DNMT1	4.17e-08	901	52	14	int:H3C1
Interaction	CBX3 interactions	RLF RSBN1 SETD2 SNW1 TRIM28 COBLL1 SUPT16H PRDM16 RSBN1L DNMT1	5.01e-06	646	52	10	int:CBX3
Interaction	SMC5 interactions	CBLL1 RSBN1 SETD2 SNW1 TRIM28 AHNAK EIF4G2 SUPT16H COPG2 ARID1A RSBN1L DNMT1	6.83e-06	1000	52	12	int:SMC5
Interaction	SSRP1 interactions	RLF SETD2 SNW1 ZNF257 TRIM28 SUPT16H NELFB ARID1A PRDM16 SPTY2D1	8.38e-06	685	52	10	int:SSRP1
Interaction	KIF23 interactions	ALMS1 MYO5A TNPO2 AHNAK COBLL1 EIF4G2 SUPT16H COPG2 SPTY2D1 AHNAK2 NLRP13 NGDN	9.31e-06	1031	52	12	int:KIF23
Interaction	KLF3 interactions	RLF ZNF516 RFX7 ARID1A PRDM16 TBX2	2.59e-05	228	52	6	int:KLF3
Interaction	RCOR1 interactions	RLF ALMS1 TRIM28 TNPO2 AHNAK ZNF516 COPG2 PRDM16	3.59e-05	494	52	8	int:RCOR1
Interaction	MEX3A interactions	FAT1 TRIM28 AHNAK SUPT16H ARID1A DNMT1 AHNAK2	5.52e-05	384	52	7	int:MEX3A
Interaction	ZNF517 interactions	TRIM28 AHNAK ERBIN	5.65e-05	29	52	3	int:ZNF517
Interaction	ZNF257 interactions	ZNF257 TRIM28	6.50e-05	5	52	2	int:ZNF257
Interaction	YAP1 interactions	SETD2 SNW1 REPS1 TRIM28 AHNAK SUPT16H ARID1A ERBIN RSBN1L DNMT1 TBX2	8.95e-05	1095	52	11	int:YAP1
Interaction	ZNF93 interactions	ZNF93 TRIM28	9.73e-05	6	52	2	int:ZNF93
Interaction	SRSF1 interactions	CBLL1 RSBN1 SNW1 REPS1 ZRSR2 TRIM28 NELFB NGDN	9.80e-05	570	52	8	int:SRSF1
Interaction	VASP interactions	FAT1 SNW1 REPS1 ALMS1 MAP1A COBLL1	1.06e-04	294	52	6	int:VASP
Interaction	SUMO2 interactions	SNW1 TRIM28 AHNAK EIF4G2 SUPT16H NSUN2 DNMT1 AHNAK2	1.26e-04	591	52	8	int:SUMO2
Interaction	PCK2 interactions	CBLL1 TRIM28 AHNAK AHNAK2	1.67e-04	107	52	4	int:PCK2
Interaction	H2AB2 interactions	RSBN1 SUPT16H RSBN1L NGDN	1.67e-04	107	52	4	int:H2AB2
Interaction	NUP43 interactions	RLF RSBN1 SETD2 EIF4G2 SUPT16H ARID1A DNAH9 AHNAK2	1.85e-04	625	52	8	int:NUP43
Interaction	C2CD4B interactions	SETD2 FAT1 ERBIN	1.99e-04	44	52	3	int:C2CD4B
Interaction	NPM1 interactions	RSBN1 SETD2 MYO5A TRIM28 EIF4G2 SUPT16H NSUN2 SPTY2D1 RSBN1L AHNAK2 NGDN	2.02e-04	1201	52	11	int:NPM1
Interaction	PHLPP1 interactions	SNW1 AHNAK EIF4G2 COPG2 ARID1A AHNAK2	2.09e-04	333	52	6	int:PHLPP1
Interaction	SNRNP40 interactions	CBLL1 RSBN1 SETD2 SNW1 SUPT16H ARID1A SPTY2D1 RSBN1L	2.10e-04	637	52	8	int:SNRNP40
Interaction	SUZ12 interactions	CBLL1 SNW1 ALMS1 TRIM28 TNPO2 SUPT16H DNMT1 NGDN	2.26e-04	644	52	8	int:SUZ12
Interaction	ARHGAP24 interactions	ZNF729 ZNF93 ZNF257 TRIM28 EIF4G2 COPG2 NSUN2	2.38e-04	486	52	7	int:ARHGAP24
Interaction	HDLBP interactions	TYRO3 RSBN1 SNW1 REPS1 AHNAK SUPT16H RSBN1L DNMT1 NGDN	3.04e-04	855	52	9	int:HDLBP
Interaction	ROR1 interactions	SUPT16H NSUN2 ERBIN AHNAK2	3.13e-04	126	52	4	int:ROR1
Interaction	HDAC2 interactions	SNW1 AHNAK ZNF516 EIF4G2 ARID1A NSUN2 PRDM16 DNMT1 AHNAK2	3.31e-04	865	52	9	int:HDAC2
Interaction	MOB3C interactions	AHNAK EIF4G2 NELFB COPG2 NSUN2 DNMT1	3.37e-04	364	52	6	int:MOB3C
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF93 ZNF257 ZNF99	1.26e-05	122	53	4	chr19p12
Cytoband	19p12	ZNF729 ZNF93 ZNF99	1.59e-04	90	53	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr15q21	SECISBP2L MYO5A RFX7	1.15e-03	177	53	3	chr15q21
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 RLF ZNF93 ZNF257 ZNF516 ZNF552 ZNF99 PRDM16	5.40e-05	718	35	8	28
GeneFamily	PDZ domain containing	AHNAK ERBIN PRX AHNAK2	2.05e-04	152	35	4	1220
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD2 PRDM16	1.96e-03	34	35	2	487
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	RLF SNW1 ALMS1 ZRSR2 EIF4G2 SUPT16H RFX7 DNMT1	4.20e-05	532	52	8	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
ToppCell	COVID-19_Convalescent-PLT_4\|World / Disease Group and Platelet Clusters	RLF RSBN1 ZNF257 SUPT16H RSBN1L	2.80e-06	186	53	5	5954a1e3ffafb33f2a9bc87af3343f304fda4c92
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FAT1 MAP1A AHNAK COBLL1 AHNAK2	3.61e-06	196	53	5	24d64b67aa9b0e8215ad06f9101c1314b3483620
Drug	Hyoscyamine (L) [101-31-5]; Down 200; 13.8uM; HL60; HG-U133A	MYO5A APEX2 TRIM28 TNPO2 NELFB ARID1A	5.83e-06	194	53	6	1424_DN
Disease	Adenoid Cystic Carcinoma	SETD2 FAT1 ARID1A ERBIN	2.34e-05	100	49	4	C0010606
Disease	Embryonal Rhabdomyosarcoma	SETD2 ARID1A	7.52e-05	8	49	2	C0206656
Disease	serum gamma-glutamyl transferase measurement	SETD2 REPS1 MAP1A AHNAK COBLL1 FUT3 ARID1A DNMT1	1.20e-04	914	49	8	EFO_0004532
Disease	lymphocyte count	CBLL1 RSBN1 SETD2 ALMS1 AHNAK COBLL1 MED13L RFX7 SPATA32 DNMT1	1.22e-04	1464	49	10	EFO_0004587
Disease	Replication Error Phenotype	SETD2 ARID1A	2.80e-04	15	49	2	C1721098
Disease	Microsatellite Instability	SETD2 ARID1A	2.80e-04	15	49	2	C0920269
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	SETD2 RFX7	3.62e-04	17	49	2	DOID:0060307 (is_implicated_in)
Disease	serum alanine aminotransferase measurement	CEP68 C6orf89 AHNAK COBLL1 GRIK3 ARID1A DNMT1	5.48e-04	869	49	7	EFO_0004735
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	COBLL1 ARID1A SPTY2D1	6.03e-04	99	49	3	EFO_0004611, EFO_0007878
Disease	familial hyperlipidemia	COBLL1 ATG4C ARID1A	7.36e-04	106	49	3	MONDO_0001336
Disease	granulocyte percentage of myeloid white cells	SETD2 ZNF516 MED13L ARID1A	1.02e-03	268	49	4	EFO_0007997
Disease	non-high density lipoprotein cholesterol measurement	REPS1 COBLL1 ATG4C FUT3 ARID1A SPTY2D1	1.13e-03	713	49	6	EFO_0005689
Disease	monocyte percentage of leukocytes	SETD2 AHNAK ZNF516 MED13L ARID1A PRDM16	1.28e-03	731	49	6	EFO_0007989
Disease	lung non-small cell carcinoma (is_implicated_in)	FAT1 ARID1A DNMT1	1.61e-03	139	49	3	DOID:3908 (is_implicated_in)
Disease	Nephroblastoma	TRIM28 ARID1A	1.64e-03	36	49	2	C0027708

Protein segments in the cluster

Peptide	Gene	Start	Entry
SHKDVPPDSLMKMPL	ERBIN	1241	Q96RT1
IPDKKPMAAMEHPCE	CEP68	741	Q76N32
DDNIPEMPSPKKMHQ	DNMT1	706	P26358
FHSSSQMPSPEPMKK	ALMS1	2696	Q8TCU4
IKAPKISMPDVDLHM	AHNAK	941	Q09666
ISMPDVDLHMKGPKV	AHNAK	946	Q09666
KMPEMHFRAPKMSLP	AHNAK	1056	Q09666
PEMHFKTPKISMPDV	AHNAK	1186	Q09666
MPEMSIKPQKISIPD	AHNAK	1441	Q09666
PEMHFKAPKISMPDV	AHNAK	1846	Q09666
PEMHFKTPKISMPDI	AHNAK	2826	Q09666
MNIKAPKIPMPDFDL	AHNAK	2956	Q09666
PEMHLKAPKISMPDI	AHNAK	3736	Q09666
PEMNIKAPKISMPDI	AHNAK	4376	Q09666
PLMSALMTPKTPEEK	APEX2	416	Q9UBZ4
DDAMVSPLKPAPKMT	COBLL1	816	Q53SF7
HCPSPKKMSFRKMDP	ATG4C	366	Q96DT6
TMFPPKDPEKLQAMH	NSUN2	391	Q08J23
MKMQKAGPPVPASHI	ARID1A	1611	O14497
PITVMNKAMPVFEKP	FAT1	2171	Q14517
QESPIPDPKLMPHMK	MAP1A	1816	P78559
PDPKLMPHMKNEPTT	MAP1A	1821	P78559
MITMHSPKRSGKIPP	MED13L	356	Q71F56
MGIMKPSHPDPIIHT	KY	461	Q8NBH2
TTGHKKMPQAFEPPM	C9orf131	326	Q5VYM1
KPLLCHYMMPDEETP	PEX3	231	P56589
PVVMCVMKHLPKVPE	NELFB	111	Q8WX92
MRAPKHFLPEMLSKV	EIF4G2	571	P78344
IPERFIMPPDKHHMS	CBLL1	216	Q75N03
EKPFDMKSIPLAMAP	COPG2	571	Q9UBF2
MKPDETPMFDPSLLK	GNPNAT1	1	Q96EK6
TEAKLKDLTPPMPVM	DNAH9	4416	Q9NYC9
KDLTPPMPVMFIKAI	DNAH9	4421	Q9NYC9
PMPVMFIKAIPADKQ	DNAH9	4426	Q9NYC9
LHPEPVVGSKMHKMP	C6orf89	266	Q6UWU4
VKHKPQPPMMVKTDA	GRIK3	876	Q13003
HKPLPKGTMMETLSR	FUT3	226	P21217
EQMIPTADMPKSPFK	RSBN1	536	Q5VWQ0
QMIPVADMPKSPFKR	RSBN1L	526	Q6PCB5
VHPVPIRMTPSKIHM	REPS1	451	Q96D71
SPMMDKAKPSPSLNH	PRDM16	466	Q9HAZ2
LEHMMKAPPQEALEP	SPATA32	261	Q96LK8
PQKKSPDTFMIPMAL	SECISBP2L	21	Q93073
MPLPHAEKKSRPSMA	SPTY2D1	256	Q68D10
SLMPKEPHIREMKIY	SUPT16H	516	Q9Y5B9
LPKLQMPSFKMPEVD	AHNAK2	2731	Q8IVF2
MDLKMPAFHPKQEVP	ZNF516	671	Q92618
KPLTMKRHEMVANPS	ZNF93	61	P35789
EPWNMKRHEMVTKPP	ZNF99	61	A8MXY4
DPLRFKPHPSNMMSK	NGDN	126	Q8NEJ9
MFVPHVMEHVKMPPS	RLF	596	Q13129
GKADPEMPKRMYIHP	TBX2	176	Q13207
SEMKLPKVPEMAVPE	PRX	526	Q9BXM0
MKLPKVPEMAVPDVH	PRX	691	Q9BXM0
VVSQPPDMHLKPLMT	TNPO2	466	O14787
HSLEKKPVMPKEMVP	TEX13C	356	A0A0J9YWL9
HSLKKDPVMPQNMIP	TEX13C	566	A0A0J9YWL9
KVPVMPKEMVPLGDS	TEX13C	736	A0A0J9YWL9
HSLKKDPVMPQNMVP	TEX13C	751	A0A0J9YWL9
PMQRPMATHPDKTKL	RFX7	951	Q2KHR2
PAPVMHSPSRKMTVK	SNW1	226	Q13573
PLVSPHQDKLMSMPV	SETD2	751	Q9BYW2
PMAGVSPKKAHPCEM	ZNF552	81	Q9H707
MAAPEKMTFPEKPSH	ZRSR2	1	Q15696
LPIPMVILPFMKHGD	TYRO3	596	Q06418
LKMIVDPVEPHGEMK	TRIM28	376	Q13263
PWNMKRHEMVTKPPV	ZNF729	71	A6NN14
EPCNMKRHEMVAKPP	ZNF257	61	Q9Y2Q1
FPPHSTKPQEMKMLL	NLRP13	556	Q86W25
KEEMTLMVHVPKPGH	MYO5A	1096	Q9Y4I1