Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	HnRNP-L/PTB	PTBP3 PTBP1	4.92e-05	5	42	2	IPR006536
Domain	TPR_8	NAA15 IFT88	6.33e-03	53	42	2	PF13181
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ACSL4 PRKAR2A PLCB3 ITPR2	2.44e-05	78	31	4	M1921
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	ACSL4 PRKAR2A PLCB3 ITPR2	8.74e-05	108	31	4	M17034
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	PLCB3 ITPR2	2.08e-04	10	31	2	M47661
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	PRKAR2A PLCB3 ITPR2	2.21e-04	54	31	3	M26911
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	PLCB3 ITPR2	2.54e-04	11	31	2	M49033
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL4 PLCB3	2.54e-04	11	31	2	M27317
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL4 PLCB3	2.54e-04	11	31	2	MM15035
Pathway	BIOCARTA_AKAP13_PATHWAY	PRKAR2A AKAP13	2.54e-04	11	31	2	M17668
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ACSL4 PLCB3 ITPR2	3.18e-04	61	31	3	MM15071
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	PLCB3 ITPR2	3.60e-04	13	31	2	M47656
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	ACSL4 PLCB3 ITPR2	5.18e-04	72	31	3	MM14631
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	PLCB3 ITPR2	8.68e-04	20	31	2	M47688
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	PLCB3 ITPR2	9.58e-04	21	31	2	M47689
Pathway	REACTOME_OPIOID_SIGNALLING	PRKAR2A PLCB3 ITPR2	9.94e-04	90	31	3	M6467
Pathway	WP_G_PROTEIN_SIGNALING_PATHWAYS	PRKAR2A AKAP13 PLCB3	9.94e-04	90	31	3	MM15882
Pathway	WP_G_PROTEIN_SIGNALING	PRKAR2A AKAP13 PLCB3	1.03e-03	91	31	3	M39426
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	PLCB3 ITPR2	1.05e-03	22	31	2	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	PLCB3 ITPR2	1.05e-03	22	31	2	M47675
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	PLCB3 ITPR2	1.15e-03	23	31	2	M47676
Pubmed	Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5.	PRKAR2A AKAP13	1.49e-06	2	43	2	7929081
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	DOCK7 ACSL4 PTBP3 PRKAR2A NAA15 PTBP1 ALDH5A1	3.86e-06	534	43	7	35032548
Pubmed	Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain.	PRKAR2A AKAP13	4.48e-06	3	43	2	1618839
Pubmed	Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice.	PTBP3 PTBP1	4.48e-06	3	43	2	34214192
Pubmed	Expression of human nPTB is limited by extreme suboptimal codon content.	PTBP3 PTBP1	4.48e-06	3	43	2	18335065
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	DOCK7 PRKAR2A RTN3 RPL14 NAA15 PTBP1 ALDH5A1 GLG1 NOS1AP	8.68e-06	1139	43	9	36417873
Pubmed	Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.	ACSL4 PLCB3	8.94e-06	4	43	2	10669417
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PRKAR2A RTN3 AKAP13 RPL14 NAA15 GLG1 VPS13B ESF1 NOS1AP ITPR2	1.04e-05	1487	43	10	33957083
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ACSL4 PTBP3 PRKAR2A RTN3 RPL14 NAA15 ALDH5A1 VPS13B ESF1 ITPR2	1.10e-05	1496	43	10	32877691
Pubmed	Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development.	PRKAR2A AKAP13	1.49e-05	5	43	2	23071553
Pubmed	PTBP1 is required for embryonic development before gastrulation.	PTBP3 PTBP1	1.49e-05	5	43	2	21423341
Pubmed	Polypyrimidine tract-binding proteins are essential for B cell development.	PTBP3 PTBP1	1.49e-05	5	43	2	32081131
Pubmed	AKAP-Lbc nucleates a protein kinase D activation scaffold.	PRKAR2A AKAP13	2.23e-05	6	43	2	15383279
Pubmed	Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.	PTBP3 PTBP1	3.12e-05	7	43	2	11724819
Pubmed	Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring.	PRKAR2A AKAP13	5.35e-05	9	43	2	12672969
Pubmed	Defining the membrane proteome of NK cells.	ACSL4 PRKAR2A AKAP13 RPL14 NAA15 PTBP1 GLG1 ITPR2	8.05e-05	1168	43	8	19946888
Pubmed	Functional characterization of putative cilia genes by high-content analysis.	RO60 IFT88	8.15e-05	11	43	2	21289087
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DOCK7 AKAP13 EIF2D PLCB3 NAA15 ESF1	1.41e-04	650	43	6	38777146
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	PLCB3 ITPR2	1.55e-04	15	43	2	28578927
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	GGH PRKAR2A RTN3 AKAP13 RPL14 MTCL1 BABAM2 GLG1	1.66e-04	1297	43	8	33545068
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	PTBP3 AKAP13 EIF2D PTBP1 GLG1 ITPR2	2.12e-04	701	43	6	30196744
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ACSL4 AKAP13 EIF2D RPL14 POLR3B NAA15 PTBP1 ESF1	2.21e-04	1353	43	8	29467282
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	DAPK1 AKAP13 ITPR2	2.70e-04	101	43	3	18519826
Pubmed	A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.	PTBP3 PTBP1	2.80e-04	20	43	2	23636947
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DOCK7 PRKAR2A RTN3 RO60 RPL14 PTBP1 ESF1 KLHL23	3.14e-04	1425	43	8	30948266
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	GGH ACSL4 PTBP3 RPL14 PTBP1	3.24e-04	486	43	5	30940648
Pubmed	Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.	PTBP3 RPL14 PTBP1	3.37e-04	109	43	3	29511296
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ACSL4 PTBP3 RPL14 PTBP1 IFT88 KIAA0825 ESF1 CAPN11	3.40e-04	1442	43	8	35575683
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	GGH PRKAR2A RO60 PLCB3 RPL14 NAA15 PTBP1 BABAM2	3.61e-04	1455	43	8	22863883
Pubmed	HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.	PRKAR2A PLCB3	3.72e-04	23	43	2	9730685
Pubmed	The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.	PRKAR2A PLCB3	3.72e-04	23	43	2	9278385
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PLCB3 ITPR2	4.05e-04	24	43	2	10843712
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	RTN3 DAPK1 AKAP13 RPL14 PTBP1 GLG1	4.49e-04	807	43	6	30575818
Pubmed	Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.	RO60 PTBP1 ALDH5A1	5.52e-04	129	43	3	28973437
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	DOCK7 DAPK1 PLCB3 VPS13B UBXN6	6.64e-04	569	43	5	30639242
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	GGH ACSL4 PRKAR2A PLCB3	6.93e-04	325	43	4	36168628
Pubmed	Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization.	PTBP3 PTBP1	7.23e-04	32	43	2	36252997
Pubmed	Genome-wide association study of smoking behaviours among Bangladeshi adults.	VPS13B ITPR2	8.17e-04	34	43	2	24665060
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DOCK7 AKAP13 RPL14 MTCL1 PTBP1	8.48e-04	601	43	5	33658012
Pubmed	A protein interaction landscape of breast cancer.	ACSL4 RO60 RPL14 BABAM2 ALDH5A1	1.08e-03	634	43	5	34591612
Pubmed	Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.	PRKAR2A RTN3 BABAM2	1.23e-03	170	43	3	36470425
GeneFamily	Ankyrin repeat domain containing\|Death associated protein kinases	DAPK1 STK17A	1.68e-05	5	24	2	1021
Disease	deoxycholic acid glucuronide measurement	UGT2B7 SLCO1B3	5.51e-05	8	42	2	EFO_0800575
Disease	cup-to-disc ratio measurement	DAPK1 MTCL1 PTBP1 BABAM2 GLG1	3.50e-04	430	42	5	EFO_0006939
Disease	Papillary Renal Cell Carcinoma	DAPK1 AKAP13 RPL14	8.09e-04	128	42	3	C1306837
Disease	Renal Cell Carcinoma	DAPK1 AKAP13 RPL14	8.09e-04	128	42	3	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	DAPK1 AKAP13 RPL14	8.09e-04	128	42	3	C1266043
Disease	Chromophobe Renal Cell Carcinoma	DAPK1 AKAP13 RPL14	8.09e-04	128	42	3	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	DAPK1 AKAP13 RPL14	8.09e-04	128	42	3	C1266044
Disease	Mental Retardation, Psychosocial	POLR3B NAA15 ALDH5A1	1.03e-03	139	42	3	C0025363
Disease	Profound Mental Retardation	POLR3B NAA15 ALDH5A1	1.03e-03	139	42	3	C0020796
Disease	Mental deficiency	POLR3B NAA15 ALDH5A1	1.03e-03	139	42	3	C0917816
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	NOS1AP CAPN11	1.21e-03	36	42	2	DOID:11723 (implicated_via_orthology)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DAPK1 AKAP13 RPL14	1.23e-03	148	42	3	C0279702
Disease	Carcinoma, Transitional Cell	GGH DAPK1	1.57e-03	41	42	2	C0007138
Disease	hereditary spastic paraplegia (implicated_via_orthology)	RTN3 CAPN11	1.72e-03	43	42	2	DOID:2476 (implicated_via_orthology)
Disease	interleukin 13 measurement	DAPK1 CAPN11	1.88e-03	45	42	2	EFO_0008171
Disease	developmental disorder of mental health (implicated_via_orthology)	GABRP NAA15	2.23e-03	49	42	2	DOID:0060037 (implicated_via_orthology)
Disease	ecosanoids measurement	UGT2B7 SLCO1B3	2.80e-03	55	42	2	EFO_0020044
Disease	vascular endothelial growth factor measurement	MTCL1 CAPN11	2.90e-03	56	42	2	EFO_0004762
Disease	triglycerides to total lipids in small LDL percentage	DOCK7 PLCB3	3.21e-03	59	42	2	EFO_0022337
Disease	cholesteryl esters to total lipids in large HDL percentage	DOCK7 PLCB3	3.21e-03	59	42	2	EFO_0022248
Disease	smooth surface dental caries	GABRP ITPR2	3.54e-03	62	42	2	EFO_0006339
Disease	obesity (implicated_via_orthology)	PLCB3 CAPN11 ITPR2	3.55e-03	215	42	3	DOID:9970 (implicated_via_orthology)
Disease	blood urea nitrogen measurement	DAPK1 AKAP13 PTBP1 CENPN	3.84e-03	452	42	4	EFO_0004741
Disease	word reading	DOCK7 NOS1AP	3.89e-03	65	42	2	EFO_0005300
Disease	triglycerides to phosphoglycerides ratio	DOCK7 PLCB3	4.25e-03	68	42	2	EFO_0022327

Protein segments in the cluster

Peptide	Gene	Start	Entry
YFLTNAKKKNAMAKR	ACSL4	31	O60488
RKASAVNMEKFKKFA	DAPK1	286	P53355
DFKMYIAFVFKEKKK	C6orf62	31	Q9GZU0
MFAKAFRVKSNTAIK	EIF2D	1	P41214
AKDKRFQAFVKKKMS	AKAP13	2116	Q12802
NRMAIKFKSFKTKGF	CAPN11	596	Q9UMQ6
NAKMKAFKKELQAFL	MTCL1	876	Q9Y4B5
KKSEKFFKVLYDRMK	ITPR2	1801	Q14571
KYFFFLSERKMSKKF	KIAA0825	991	Q8IV33
KRFRAMFHDKKFKLN	ESF1	36	Q9H501
LTNSKSAVMRFKKFF	ABCC11	441	Q96J66
FGKQTNKMESSRKFK	LRRC63	121	Q05C16
FKECLDKFLRMNFSK	NAA15	306	Q9BXJ9
FKMKSKEGRAKAFST	OR5K1	226	Q8NHB7
KFKSFEAARKRNKCF	PLCB3	601	Q01970
MKDFRFSYKFKMACK	GLG1	746	Q92896
FAIGDREKMKKAFQK	IFT88	316	Q13099
YFKAMFTADMKEKFK	KLHL23	61	Q8NBE8
QQFRKMVESRKSFKF	CCDC63	36	Q8NA47
KVFERMNSLTFKKSK	DOCK7	1376	Q96N67
NEMAKRAKAYFKTFV	BABAM2	356	Q9NXR7
VKNFTMNEKLKKFFN	GGH	201	Q92820
VDLFDMKQFKNSFKK	CENPN	96	Q96H22
IVKNNAKKRKMFESF	PRKAR2A	241	P13861
RMFSFYQAKEKFKKE	FAM135B	1091	Q49AJ0
FRCNVFKSKKKSQAM	NOS1AP	141	O75052
KTSDKFKFVFREKMG	GABRP	386	O00591
RNAFKAISEKMTDFK	RTN3	671	O95197
FVKAFAEAMKKNLRV	ALDH5A1	356	P51649
FTFIQFKKDLKESMK	RO60	126	P10155
KDSGKEFAAKFMRKR	STK17A	81	Q9UEE5
MKKFFQEFKADIKFK	UBXN6	1	Q9BZV1
SDLGMNIFKKFKSRK	UNC80	436	Q8N2C7
DFDRFKVMKAKKMRN	RPL14	106	P50914
IVFIFAMKKKFQGKD	SLCO1B3	641	Q9NPD5
LFKKFNSEMKKIADQ	POLR3B	376	Q9NW08
FAKKKAFALFVKTKE	TSTD2	51	Q5T7W7
SVKAFKFFQKDRKMA	PTBP3	501	O95758
FAQVFLSKFTMVKNK	VPS13B	4001	Q7Z7G8
MTEGTKKTSKKFKFF	SH2D3C	1	Q8N5H7
VSNKKFMKKVQESRF	UGT2B7	131	P16662
EKMYFRKFFKFQVLK	TRAPPC13	156	A5PLN9
VKGFKFFQKDRKMAL	PTBP1	481	P26599