Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin binding	SPATA31A1 SPATA31A3 SPATA31A7 WHAMM WDR1 PLEKHH2 SHROOM2 SPATA31A6 SPATA31A5 CAP2	4.87e-05	479	88	10	GO:0003779
Domain	ZnF_C2HC	FAM90A14 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	1.56e-07	55	83	6	SM00343
Domain	Znf_CCHC	FAM90A14 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	1.56e-07	55	83	6	IPR001878
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.75e-07	12	83	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.75e-07	12	83	4	IPR027970
Domain	Dishevelled_fam	DVL1P1 DVL1 DVL2	3.37e-07	4	83	3	IPR008339
Domain	Dishevelled	DVL1P1 DVL1 DVL2	3.37e-07	4	83	3	PF02377
Domain	Dishevelled_protein_dom	DVL1P1 DVL1 DVL2	3.37e-07	4	83	3	IPR003351
Domain	DIX	DVL1P1 DVL1 DVL2	2.92e-06	7	83	3	PF00778
Domain	DIX	DVL1P1 DVL1 DVL2	2.92e-06	7	83	3	IPR001158
Domain	DIX	DVL1P1 DVL1 DVL2	2.92e-06	7	83	3	PS50841
Domain	DAX	DVL1P1 DVL1 DVL2	2.92e-06	7	83	3	SM00021
Domain	DVL-1	DVL1P1 DVL1	1.95e-05	2	83	2	IPR008340
Domain	Dsh_C	DVL1 DVL2	5.84e-05	3	83	2	PF12316
Domain	Dishevelled_C-dom	DVL1 DVL2	5.84e-05	3	83	2	IPR024580
Domain	Dsh/Dvl-rel	DVL1 DVL2	1.16e-04	4	83	2	IPR015506
Domain	DEP	DVL1P1 DVL1 DVL2	1.23e-04	22	83	3	PF00610
Domain	DEP	DVL1P1 DVL1 DVL2	1.23e-04	22	83	3	PS50186
Domain	DEP	DVL1P1 DVL1 DVL2	1.23e-04	22	83	3	SM00049
Domain	DEP_dom	DVL1P1 DVL1 DVL2	1.41e-04	23	83	3	IPR000591
Domain	TSP_1	SPON2 PAPLN SSPOP ADAMTSL4	1.77e-04	63	83	4	PF00090
Domain	TSP1	SPON2 PAPLN SSPOP ADAMTSL4	2.00e-04	65	83	4	SM00209
Domain	TSP1_rpt	SPON2 PAPLN SSPOP ADAMTSL4	2.00e-04	65	83	4	IPR000884
Domain	TSP1	SPON2 PAPLN SSPOP ADAMTSL4	2.00e-04	65	83	4	PS50092
Domain	GPS	CELSR2 PKD1 ADGRD2	4.58e-04	34	83	3	SM00303
Domain	GPS	CELSR2 PKD1 ADGRD2	5.00e-04	35	83	3	PF01825
Domain	GPS	CELSR2 PKD1 ADGRD2	5.44e-04	36	83	3	PS50221
Domain	GPS	CELSR2 PKD1 ADGRD2	5.90e-04	37	83	3	IPR000203
Domain	-	SEMA7A RBBP7 NBEAL2 FSTL4 NUP133 WDR1 HIRA	7.00e-04	333	83	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEMA7A RBBP7 NBEAL2 FSTL4 NUP133 WDR1 HIRA	7.25e-04	335	83	7	IPR015943
Domain	LDLRA_1	TMPRSS15 PKD1 SSPOP	1.27e-03	48	83	3	PS01209
Domain	LDLRA_2	TMPRSS15 PKD1 SSPOP	1.35e-03	49	83	3	PS50068
Domain	ig	SDK2 SIGLEC10 FSTL4 SIGLEC5 PTGFRN	1.58e-03	190	83	5	PF00047
Domain	Immunoglobulin	SDK2 SIGLEC10 FSTL4 SIGLEC5 PTGFRN	1.58e-03	190	83	5	IPR013151
Domain	PLAC	PAPLN ADAMTSL4	1.72e-03	14	83	2	PF08686
Domain	Ig-like_dom	SDK2 SEMA7A PTCRA SIGLEC10 FSTL4 SIGLEC5 PAPLN PTGFRN	1.76e-03	503	83	8	IPR007110
Domain	N2O_reductase_N	RBBP7 WDR1	1.97e-03	15	83	2	IPR011045
Domain	IG	SDK2 SEMA7A SIGLEC10 FSTL4 SIGLEC5 PAPLN PTGFRN	2.68e-03	421	83	7	SM00409
Domain	Ig_sub	SDK2 SEMA7A SIGLEC10 FSTL4 SIGLEC5 PAPLN PTGFRN	2.68e-03	421	83	7	IPR003599
Domain	-	SDK2 SEMA7A PTCRA SIGLEC10 FSTL4 SIGLEC5 PAPLN USH2A PTGFRN	2.68e-03	663	83	9	2.60.40.10
Domain	ConA-like_dom	TMPRSS15 CELSR2 NBEAL2 ADGRD2 USH2A	2.93e-03	219	83	5	IPR013320
Domain	PLAC	PAPLN ADAMTSL4	3.18e-03	19	83	2	PS50900
Domain	PLAC	PAPLN ADAMTSL4	3.18e-03	19	83	2	IPR010909
Domain	PDZ	DVL1P1 DVL1 DVL2 SHROOM2	3.61e-03	141	83	4	PF00595
Domain	IGc2	SDK2 SIGLEC10 FSTL4 SIGLEC5 PAPLN	3.96e-03	235	83	5	SM00408
Domain	Ig_sub2	SDK2 SIGLEC10 FSTL4 SIGLEC5 PAPLN	3.96e-03	235	83	5	IPR003598
Domain	Ig-like_fold	SDK2 SEMA7A PTCRA SIGLEC10 FSTL4 SIGLEC5 PAPLN USH2A PTGFRN	4.06e-03	706	83	9	IPR013783
Domain	PDZ	DVL1P1 DVL1 DVL2 SHROOM2	4.29e-03	148	83	4	SM00228
Domain	PDZ	DVL1P1 DVL1 DVL2 SHROOM2	4.60e-03	151	83	4	PS50106
Domain	ADAM_spacer1	PAPLN ADAMTSL4	4.65e-03	23	83	2	IPR010294
Domain	ADAM_spacer1	PAPLN ADAMTSL4	4.65e-03	23	83	2	PF05986
Domain	PDZ	DVL1P1 DVL1 DVL2 SHROOM2	4.71e-03	152	83	4	IPR001478
Domain	IG_LIKE	SDK2 SEMA7A SIGLEC10 FSTL4 SIGLEC5 PAPLN PTGFRN	6.19e-03	491	83	7	PS50835
Domain	ArfGap	GIT2 ARAP1	7.33e-03	29	83	2	SM00105
Domain	ArfGap	GIT2 ARAP1	7.33e-03	29	83	2	PF01412
Domain	ARFGAP	GIT2 ARAP1	7.33e-03	29	83	2	PS50115
Domain	ArfGAP	GIT2 ARAP1	7.33e-03	29	83	2	IPR001164
Domain	EGF_LAM_2	CELSR2 USH2A	7.83e-03	30	83	2	PS50027
Pathway	PID_BETA_CATENIN_DEG_PATHWAY	DVL1 DVL2 SSPOP	5.43e-05	18	59	3	M31
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	1.33e-22	25	94	11	17684299
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A16 FAM90A10	1.41e-20	23	94	10	18602769
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	7.75e-13	6	94	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	7.75e-13	6	94	5	25930072
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A26 FAM90A23 PLEKHH2 FAM90A7 FAM90A9 FAM90A8 FAM90A10	9.00e-13	164	94	11	22967998
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	5.28e-09	24	94	5	32212159
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1 DVL2	7.63e-08	4	94	3	8817329
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1 DVL2	7.63e-08	4	94	3	9192851
Pubmed	Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro.	CES1P1 CES1	7.23e-06	2	94	2	17264798
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	7.23e-06	2	94	2	8644734
Pubmed	Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus.	CES1P1 CES1	7.23e-06	2	94	2	26871237
Pubmed	Wnt-mediated relocalization of dishevelled proteins.	DVL1 DVL2	7.23e-06	2	94	2	8856345
Pubmed	Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.	GDF15 LEP	7.23e-06	2	94	2	29046435
Pubmed	Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways.	DVL1 DVL2	2.16e-05	3	94	2	15852005
Pubmed	Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.	DVL1 DVL2	2.16e-05	3	94	2	18093802
Pubmed	DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.	DVL1 DVL2	2.16e-05	3	94	2	32900645
Pubmed	Inverse agonist of nuclear receptor ERRγ mediates antidiabetic effect through inhibition of hepatic gluconeogenesis.	ESRRG LEP	2.16e-05	3	94	2	23775767
Pubmed	Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.	DVL1 DVL2	2.16e-05	3	94	2	27744318
Pubmed	OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.	SIGLEC5 LEP	2.16e-05	3	94	2	10428856
Pubmed	Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells.	DVL1 DVL2	2.16e-05	3	94	2	20224554
Pubmed	Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms.	CES1P1 CES1	2.16e-05	3	94	2	10452915
Pubmed	Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.	DVL1 DVL2	2.16e-05	3	94	2	16116426
Pubmed	Camptothecin effectively treats obesity in mice through GDF15 induction.	GDF15 LEP	2.16e-05	3	94	2	35202387
Pubmed	Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.	CES1 LEP	2.16e-05	3	94	2	25285996
Pubmed	Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.	CES1P1 CES1	2.16e-05	3	94	2	20195289
Pubmed	The DIX domain targets dishevelled to actin stress fibres and vesicular membranes.	DVL1P1 DVL2	2.16e-05	3	94	2	12384700
Pubmed	Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.	DVL1 DVL2	2.16e-05	3	94	2	27086035
Pubmed	Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway.	DVL1 DVL2	2.16e-05	3	94	2	10409711
Pubmed	Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.	DVL1 DVL2	2.16e-05	3	94	2	21092292
Pubmed	Mechanism of activation of the Formin protein Daam1.	DVL1 DVL2	2.16e-05	3	94	2	18162551
Pubmed	Genomic organization of mouse Dishevelled genes.	DVL1 DVL2	2.16e-05	3	94	2	8973355
Pubmed	Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.	DVL1 DVL2	2.16e-05	3	94	2	18692936
Pubmed	Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice.	LEP KLB	2.16e-05	3	94	2	28650457
Pubmed	beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.	DVL1 DVL2	2.16e-05	3	94	2	11742073
Pubmed	Increased Growth Differentiation Factor 15 in Patients with Hypoleptinemia-Associated Lipodystrophy.	GDF15 LEP	2.16e-05	3	94	2	33003626
Pubmed	Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.	DVL1 DVL2	2.16e-05	3	94	2	23437169
Pubmed	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.	DVL1 DVL2	4.32e-05	4	94	2	24643799
Pubmed	Molecular basis of Wnt activation via the DIX domain protein Ccd1.	DVL1 DVL2	4.32e-05	4	94	2	21189423
Pubmed	Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.	DVL1 DVL2	4.32e-05	4	94	2	12533515
Pubmed	Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.	DVL1 DVL2	4.32e-05	4	94	2	19465938
Pubmed	DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.	DVL1 DVL2	4.32e-05	4	94	2	25557784
Pubmed	αPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes.	PTCRA GIT2	4.32e-05	4	94	2	24591366
Pubmed	Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.	DVL1 DVL2	4.32e-05	4	94	2	25891077
Pubmed	Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes.	CES1P1 CES1	4.32e-05	4	94	2	18794728
Pubmed	Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.	DVL1 DVL2	4.32e-05	4	94	2	19625296
Pubmed	Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.	DVL1P1 DVL1	4.32e-05	4	94	2	20639201
Pubmed	Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation.	DVL1 DVL2	4.32e-05	4	94	2	16571627
Pubmed	Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.	DVL1 DVL2	4.32e-05	4	94	2	25043421
Pubmed	Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.	DVL1 DVL2	4.32e-05	4	94	2	23371553
Pubmed	Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.	DVL1 DVL2	4.32e-05	4	94	2	18772438
Pubmed	Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways.	DVL1 DVL2	4.32e-05	4	94	2	17593335
Pubmed	The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors.	DVL1 DVL2	4.32e-05	4	94	2	27599467
Pubmed	Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.	KLF14 LEP	4.32e-05	4	94	2	26368306
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOCAD PRKD2 CELSR2 SEMA7A MFHAS1 NBEAL2 PKD1 DVL1 KDM3B PAPLN ARAP1 HIRA	4.33e-05	1105	94	12	35748872
Pubmed	Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.	DVL1 DVL2	7.19e-05	5	94	2	15456783
Pubmed	Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation.	PRKD2 PKD1	7.19e-05	5	94	2	15623513
Pubmed	The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.	DVL1 DVL2	7.19e-05	5	94	2	22826439
Pubmed	Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation.	DVL1 DVL2	7.19e-05	5	94	2	21262972
Pubmed	A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.	DVL1 DVL2	7.19e-05	5	94	2	25424568
Pubmed	CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.	DVL1 DVL2	7.19e-05	5	94	2	24469800
Pubmed	A hippocampal nicotinic acetylcholine alpha 7-containing receptor complex is linked to memory retrieval in the multiple-T-maze in C57BL/6j mice.	HTR7 CHRNA7	7.19e-05	5	94	2	24837029
Pubmed	Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.	DVL1 DVL2	7.19e-05	5	94	2	11779461
Pubmed	A unique FGF23 with the ability to activate FGFR signaling through both αKlotho and βKlotho.	LEP KLB	7.19e-05	5	94	2	22370560
Pubmed	Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.	CELSR2 DVL1 DVL2	8.96e-05	32	94	3	23177622
Pubmed	Comprehensive proteomic characterization of stem cell-derived extracellular matrices.	SEMA7A GDF15 F2 ADAMTSL4	8.97e-05	86	94	4	28327460
Pubmed	Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.	DVL1 DVL2	1.08e-04	6	94	2	34139860
Pubmed	USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.	UBA7 UBE2Z	1.08e-04	6	94	2	20975683
Pubmed	Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation.	DVL1 DVL2	1.08e-04	6	94	2	21880741
Pubmed	Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).	SIGLEC10 SIGLEC5	1.08e-04	6	94	2	14559209
Pubmed	Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.	DVL1 DVL2	1.08e-04	6	94	2	32579954
Pubmed	Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.	CES1P1 CES1	1.08e-04	6	94	2	20931200
Pubmed	SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.	DVL1 DVL2	1.08e-04	6	94	2	20439735
Pubmed	Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.	DVL1 DVL2	1.50e-04	7	94	2	17005174
Pubmed	Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.	DVL1 DVL2	1.50e-04	7	94	2	10330403
Pubmed	The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.	DVL1 DVL2	1.50e-04	7	94	2	15262978
Pubmed	Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.	DVL1 DVL2	1.50e-04	7	94	2	22841628
Pubmed	Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.	DVL1 DVL2	1.50e-04	7	94	2	10806215
Pubmed	Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.	DVL1 DVL2	1.50e-04	7	94	2	19008950
Pubmed	USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling.	DVL1 DVL2	1.50e-04	7	94	2	33786993
Pubmed	The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.	CELSR2 DVL1 DVL2	1.89e-04	41	94	3	30022023
Pubmed	All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.	DVL1 DVL2	2.00e-04	8	94	2	21718540
Pubmed	Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.	DVL1 DVL2	2.00e-04	8	94	2	15454084
Pubmed	Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.	DVL1 DVL2	2.00e-04	8	94	2	22773187
Pubmed	Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.	DVL1 DVL2	2.00e-04	8	94	2	12165471
Pubmed	Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.	PTCRA PKD1	2.00e-04	8	94	2	22795130
Pubmed	A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).	DVL1P1 DVL1	2.00e-04	8	94	2	19643732
Pubmed	Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.	DVL1 DVL2	2.00e-04	8	94	2	19388021
Pubmed	Expression of planar cell polarity genes during development of the mouse CNS.	DVL1 DVL2	2.57e-04	9	94	2	16487141
Pubmed	Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.	CELSR2 WDR1	2.57e-04	9	94	2	18179892
Pubmed	RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.	DVL1 DVL2	2.57e-04	9	94	2	32965059
Pubmed	Regulation of the Wnt signaling pathway by disabled-2 (Dab2).	DVL1 DVL2	2.57e-04	9	94	2	12805222
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	EPS15 CELSR2 SEMA7A PKD1 SLC24A1 SHROOM2	2.77e-04	329	94	6	17474147
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	CELSR2 DVL1 DVL2	2.84e-04	47	94	3	33141892
Pubmed	Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.	DVL1 DVL2	3.21e-04	10	94	2	15143170
Pubmed	Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.	DVL1 DVL2	3.21e-04	10	94	2	15637299
Pubmed	Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.	SIGLEC10 SIGLEC5	3.21e-04	10	94	2	25320078
Pubmed	Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes.	GIT2 SNRNP200 KIF24	3.22e-04	49	94	3	17567985
Pubmed	Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.	DVL1 DVL2	3.91e-04	11	94	2	10644691
Pubmed	Microtubules enable the planar cell polarity of airway cilia.	DVL1 DVL2	4.69e-04	12	94	2	23122850
Pubmed	Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation.	BUB1 HIRA	4.69e-04	12	94	2	16595651
Cytoband	8p23.1	FAM90A14 FAM90A17 MFHAS1 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	4.95e-16	154	94	12	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	FAM90A14 FAM90A17 MFHAS1 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10 FAM87A	2.34e-15	234	94	13	chr8p23
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	1.15e-04	8	94	2	chr9q12
Cytoband	19q13.3	PRKD2 SIGLEC10 SIGLEC5	6.55e-04	82	94	3	19q13.3
Cytoband	9p13.1	SPATA31A1 SPATA31A3	1.11e-03	24	94	2	9p13.1
GeneFamily	Dishevelled segment polarity proteins\|PDZ domain containing	DVL1 DVL2	5.23e-05	4	54	2	505
GeneFamily	ADAMTS like	PAPLN ADAMTSL4	1.82e-04	7	54	2	947
GeneFamily	Immunoglobulin like domain containing	SDK2 SEMA7A FSTL4 PTGFRN	2.62e-03	193	54	4	594
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC10 SIGLEC5	3.15e-03	28	54	2	745
Disease	Sclerocystic Ovaries	PRKD2 PTCRA KICS2 ABCB6 ADGRD2 LEP	2.01e-06	144	76	6	C1136382
Disease	Polycystic Ovary Syndrome	PRKD2 PTCRA KICS2 ABCB6 ADGRD2 LEP	2.01e-06	144	76	6	C0032460
Disease	Congenital hypogonadotropic hypogonadism	SEMA7A KLB	6.55e-06	2	76	2	C3899503
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	6.51e-05	5	76	2	DOID:11198 (is_implicated_in)
Disease	cognitive disorder (implicated_via_orthology)	HTR7 CHRNA7	9.75e-05	6	76	2	DOID:1561 (implicated_via_orthology)
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	CELSR2 CES1 MFHAS1 KLF14 SPG11	2.93e-04	225	76	5	EFO_0008317, EFO_0020947
Disease	BMI-adjusted leptin measurement	KLF14 LEP	6.73e-04	15	76	2	EFO_0007793
Disease	Non-alcoholic Fatty Liver Disease	F2 LEP KLB	7.94e-04	70	76	3	C0400966
Disease	Nonalcoholic Steatohepatitis	F2 LEP KLB	7.94e-04	70	76	3	C3241937
Disease	body fat percentage, type 2 diabetes mellitus	KLF14 ARAP1	8.68e-04	17	76	2	EFO_0007800, MONDO_0005148
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	CELSR2 CES1 MFHAS1 KLF14 SPG11	9.40e-04	291	76	5	EFO_0008317, EFO_0020946
Disease	CCL4 measurement	AMZ1 ACKR2	1.21e-03	20	76	2	EFO_0004751
Disease	Nerve Degeneration	F2 LEP CHRNA7	1.30e-03	83	76	3	C0027746
Disease	nucleus accumbens volume	ESRRG USH2A	1.46e-03	22	76	2	EFO_0006931
Disease	anxiety disorder (implicated_via_orthology)	HTR7 KDM3B	1.46e-03	22	76	2	DOID:2030 (implicated_via_orthology)
Disease	gout	PRKD2 FSTL4 WDR1 PTGFRN	1.67e-03	196	76	4	EFO_0004274
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	CELSR2 MFHAS1 KLF14 SPG11	1.80e-03	200	76	4	EFO_0004611, EFO_0020945
Disease	Acute Confusional Senile Dementia	F2 LEP CHRNA7	2.16e-03	99	76	3	C0546126
Disease	Alzheimer's Disease, Focal Onset	F2 LEP CHRNA7	2.16e-03	99	76	3	C0750900
Disease	Alzheimer Disease, Early Onset	F2 LEP CHRNA7	2.16e-03	99	76	3	C0750901
Disease	Presenile dementia	F2 LEP CHRNA7	2.16e-03	99	76	3	C0011265
Disease	Alzheimer Disease, Late Onset	F2 LEP CHRNA7	2.16e-03	99	76	3	C0494463
Disease	retinitis pigmentosa (implicated_via_orthology)	USH2A SNRNP200	2.20e-03	27	76	2	DOID:10584 (implicated_via_orthology)
Disease	Familial Alzheimer Disease (FAD)	F2 LEP CHRNA7	2.22e-03	100	76	3	C0276496
Disease	Alzheimer's Disease	F2 LEP CHRNA7	2.28e-03	101	76	3	C0002395
Disease	Crohn's disease (is_marker_for)	F2 CHRNA7	2.54e-03	29	76	2	DOID:8778 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGWHLAPGTAQASLS	ACKR2	331	O00590
FILATLSASAAWGHP	CES1	6	P23141
LTALSRPGTSLFSWH	CYB561D1	41	Q8N8Q1
LGLTLSDLYPHEAWS	AMZ1	176	Q400G9
LLSNGPHASSLWSLF	ADAMTSL4	341	Q6UY14
TLSSPLYIAWAGHLE	BUB1	96	O43683
LSPISGGIWHSVLHS	APOBEC4	186	Q8WW27
HSPGLLLLWTVAFAA	ABCB6	146	Q9NP58
GANSIWEHSLLDPAS	GIT2	71	Q14161
GSSLVAWHGLSLPIS	CELSR2	1621	Q9HCU4
SSPAAWRYLHAVLGL	DNHD1	76	Q96M86
ALWPGLAASPSTVHS	DNHD1	3956	Q96M86
PAAWVSHSAALTGTF	DVL2	376	O14641
NGRWSSSLLAAPSFH	FAM90A10	401	A6NDY2
GGVWLALAASLLHVS	CHRNA7	6	P36544
PRIWSLAHTATAAAA	IRX4	366	P78413
NGRWSSSLLAAPSFH	FAM90A7	401	A6NKC0
SFWSLILSHPSGAVS	ODF4	206	Q2M2E3
LVLATLAASAAWAGH	CES1P1	6	Q9UKY3
AWAGHLSSPPLVDTL	CES1P1	16	Q9UKY3
NGRWSSSLLAAPSFH	FAM90A23	401	A8MXZ1
GLVILAAAWHSADNP	NUP133	351	Q8WUM0
SQAWLGLLAGAHSSL	PLD3	106	Q8IV08
ATDGTWTNLAHLSLP	PTCRA	81	Q6ISU1
AGSWVIGNTSALPHT	OR1A2	146	Q9Y585
ALLATGTWLSGSLHS	OR10G7	141	Q8NGN6
ALLATGTWLSGSLHS	OR10G4	141	Q8NGN3
GLSSLWAAVSSHQPI	SLC24A1	46	O60721
LSIASHASLPNIWTA	MFHAS1	941	Q9Y4C4
GASLVSSDWLVSAAH	TMPRSS15	811	P98073
NHLSAVSESIPALGW	CAP2	131	P40123
NGRWSSSLLAAPSFH	FAM90A22	401	A8MWA6
NGRWSSSLLAAPSFH	FAM90A14	401	P0C7W9
WLHALTFPAAALALS	GPR26	131	Q8NDV2
TFPAAALALSWLGFH	GPR26	136	Q8NDV2
AALPVSSATRHLWLS	KIF24	1101	Q5T7B8
APPSSALHWLADLAT	KDM3B	1216	Q7LBC6
LAFSKSCHLPWASGL	LEP	111	P41159
SPWSHISAGAIDLIN	PRKD2	771	Q9BZL6
LSWLPHGGALSLAEA	GDF15	21	Q99988
SLGPWAAGTHFLAIS	PRR25	61	Q96S07
AAGTHFLAISTTPWG	PRR25	66	Q96S07
NGRWSSSLLAAPSFH	FAM90A17	401	P0DV74
ARAHSLTSSIPGAWI	MTPAP	361	Q9NVV4
NGRWSSSLLAAPSFH	FAM90A16	401	P0DV73
NGRWSSSLLAAPSFH	FAM90A19	401	P0DV76
PSSLGSTFLWLAVHE	PLEKHH2	1361	Q8IVE3
GLSWNSNLSGHLLSA	RBBP7	181	Q16576
HLWSPFGLRSLAASS	MOGS	721	Q13724
SAGGSWLSLLAALAH	KICS2	46	Q96MD2
NGRWSSSLLAAPSFH	FAM90A8	401	A6NJQ4
RSHLLAADAPSSAAW	DOK1	96	Q99704
GWAKHIPGFSTLSLA	ESRRG	281	P62508
FWLHLTLLGASLPAA	FSTL4	6	Q6MZW2
LLWSGHSPLSLSIAS	ANKMY1	691	Q9P2S6
GAVSLSLHADWAEPA	KLB	736	Q86Z14
AGGAAPHLLAASVWA	KLF14	76	Q8TD94
PHLLAASVWADLRGS	KLF14	81	Q8TD94
AAWLSHTAALTGALP	DVL1	361	O14640
GLPSTLLAHIWSLCD	EPS15	256	P42566
NGRWSSSLLAAPSFH	FAM90A20P	401	A6NIJ5
LRLSWSPDGHYLVSA	HIRA	226	P54198
AAWLSHTAALTGALP	DVL1P1	361	P54792
HHGPAFWITLTTGLL	DUOXA1	246	Q1HG43
NGRWSSSLLAAPSFH	FAM90A5P	401	A8MXJ8
ELPSGRWALHSASVS	SDK2	1441	Q58EX2
LWRTTPEAHASSLGA	SLC39A14	21	Q15043
LAWAALGCKHPVLST	FAM87A	256	P0C7U9
SPAHHLWSLLSEATG	FOCAD	1521	Q5VW36
DHTAPLLLGLSASWL	FOCAD	1686	Q5VW36
NGRWSSSLLAAPSFH	FAM90A24P	401	P0C7X0
PAWCASLAHGLSLLL	PKD1	3551	P98161
AASASPLHTHLALLW	PTGFRN	171	Q9P2B2
PSITALSAVALHLSW	USH2A	3596	O75445
PAQWSSLLGAAHSSD	SPON2	66	Q9BUD6
LAGAADSTWAVHLTP	SSPOP	221	A2VEC9
FWGLPSLHSESLVAN	SPATA31A6	416	Q5VVP1
NGRWSSSLLAAPSFH	FAM90A12P	401	A8MX19
VSASGLLGTHSWLPY	NBEAL2	2411	Q6ZNJ1
NGRWSSSLLAAPSFH	FAM90A9	401	A6NNJ1
NGRWSSSLLAAPSFH	FAM90A13P	401	P0C7W8
FWGLPSLHSESLVAN	SPATA31A7	416	Q8IWB4
NGRWSSSLLAAPSFH	FAM90A26	401	D6RGX4
SSAGPWANSSLILHG	SIGLEC5	386	O15389
WANSSLILHGGLSSD	SIGLEC5	391	O15389
LHARGQDSWPVSSAL	SHROOM2	1041	Q13796
HVSAIPWGISATAAL	PRDX3	16	P30048
AAVSPSSWAGLLSAA	WHAMM	71	Q8TF30
GIYAISWSPDSTHLL	WDR1	236	O75083
NGRWSSSLLAAPSFH	FAM90A15P	401	P0C7V4
AGSWAPHLLSEVTAS	HTR7	41	P34969
LAGILVHLSPAWAYA	ADGRD2	871	Q7Z7M1
VPNGGWHTSSLSLSL	ARAP1	291	Q96P48
SANTLAIGDAWSHLP	SPG11	1166	Q96JI7
FWGLPSLHSESLVAN	SPATA31A3	416	Q5VYP0
FWGLPSLHSESLVAN	SPATA31A1	416	Q5TZJ5
FWGLPSLHSESLVAN	SPATA31A5	416	Q5VU36
LLHGSALLYAAGWSP	UBA7	946	P41226
GHWTIEAARALPAAS	PAPLN	236	O95428
GALTWPSLAAAIHAQ	RNASEH2C	146	Q8TDP1
LLWAAAASAQGHLRS	SEMA7A	36	O75326
GAALLSHWDPTLSSD	UBE2Z	76	Q9H832
STATLAWGVNLPAHT	SNRNP200	811	O75643
AVTTHGLPCLAWASA	F2	226	P00734
LSLSIPAATWGHPLT	USP30	251	Q70CQ3
PWANSSLSLHGGLSS	SIGLEC10	501	Q96LC7
NGRWSSSLLAAPSFH	FAM90A18	401	P0DV75