Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ONECUT2 FOXR1 POU4F1 AHRR HIVEP2 BCL6 ERG ZNF337 TCF7L1 NFIX MYBL2	2.30e-04	1412	45	11	GO:0000981
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ONECUT2 FOXR1 POU4F1 HIVEP2 ERG NFIX MYBL2	2.36e-04	560	45	7	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ONECUT2 FOXR1 POU4F1 HIVEP2 ERG NFIX MYBL2	2.52e-04	566	45	7	GO:0001216
GeneOntologyMolecularFunction	chromatin binding	ANKRD17 NCOR1 POU4F1 BCL6 ERG TCF7L1 NFIX	1.23e-03	739	45	7	GO:0003682
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ONECUT2 NCOR1 POU4F1 HIVEP2 BCL6 ERG ZNF337 TCF7L1 NFIX MYBL2	1.26e-03	1459	45	10	GO:0000977
Domain	MYB_LIKE	GON4L NCOR1 MYBL2	1.04e-04	38	45	3	PS50090
Domain	Homeodomain-like	ONECUT2 GON4L NCOR1 POU4F1 SEMA6D MYBL2	1.37e-04	332	45	6	IPR009057
Domain	SANT	GON4L NCOR1 MYBL2	2.37e-04	50	45	3	SM00717
Domain	SANT/Myb	GON4L NCOR1 MYBL2	2.66e-04	52	45	3	IPR001005
Domain	-	ONECUT2 GON4L NCOR1 POU4F1 MYBL2	5.74e-04	283	45	5	1.10.10.60
Domain	TIR	TLR6 TICAM1	1.51e-03	24	45	2	PS50104
Domain	PAS	KCNH6 AHRR	1.64e-03	25	45	2	PF00989
Domain	PAS_fold	KCNH6 AHRR	1.64e-03	25	45	2	IPR013767
Domain	TIR_dom	TLR6 TICAM1	1.64e-03	25	45	2	IPR000157
Domain	-	ONECUT2 POU4F1	1.92e-03	27	45	2	1.10.260.40
Domain	Lambda_DNA-bd_dom	ONECUT2 POU4F1	2.21e-03	29	45	2	IPR010982
Domain	PAS	KCNH6 AHRR	3.03e-03	34	45	2	IPR000014
Domain	PAS	KCNH6 AHRR	3.03e-03	34	45	2	PS50112
Domain	Myb_DNA-binding	NCOR1 MYBL2	3.21e-03	35	45	2	PF00249
Domain	Quinoprotein_ADH-like_supfam	EMC1 UTP4	7.23e-03	53	45	2	IPR011047
Pubmed	A census of human transcription factors: function, expression and evolution.	ONECUT2 GON4L FOXR1 POU4F1 HIVEP2 BCL6 ERG TCF7L1 NFIX MYBL2	2.44e-07	908	46	10	19274049
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK3 AHRR MINAR1 ENPP4 FAM120A EXPH5 UTP4 SBF2	2.51e-07	493	46	8	15368895
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	FBRSL1 ANKRD17 DAP HIVEP2 TNRC6C FAM120A NFIX SH3BP2 SBF2 RAI1 PDZD2	2.86e-06	1489	46	11	28611215
Pubmed	The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.	NCOR1 MYBL2	5.13e-06	3	46	2	11997503
Pubmed	The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG.	NCOR1 ERG	5.13e-06	3	46	2	37735473
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ONECUT2 POU4F1 BCL6 ERG TCF7L1 NFIX MYBL2	6.96e-06	544	46	7	28473536
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	DAP AHRR BCL6 TLR6 IK SH3BP2 IFNLR1 PDZD2	1.13e-05	824	46	8	20237496
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FBRSL1 DOCK3 NCOR1 HIVEP2 TNRC6C IFNLR1 SBF2 RAI1 MYBL2	1.22e-05	1105	46	9	35748872
Pubmed	Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.	NCOR1 BCL6	1.71e-05	5	46	2	11865059
Pubmed	Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.	NCOR1 BCL6	1.71e-05	5	46	2	15531890
Pubmed	Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice.	TLR6 TICAM1	2.56e-05	6	46	2	21482737
Pubmed	The AHR repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils.	AHRR TICAM1	2.56e-05	6	46	2	38701199
Pubmed	Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium.	TICAM1 IFNLR1	2.56e-05	6	46	2	35137688
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	NCOR1 BCL6 IK NFIX RAI1	2.77e-05	268	46	5	33640491
Pubmed	MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.	NCOR1 BCL6	3.58e-05	7	46	2	15454082
Pubmed	Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.	POU4F1 TCF7L1	4.77e-05	8	46	2	22930747
Pubmed	Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia.	TICAM1 IFNLR1	4.77e-05	8	46	2	24278020
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	FBRSL1 POC5 TNRC6C IK SH3BP2 TICAM1 UTP4 SBF2	5.84e-05	1038	46	8	26673895
Pubmed	Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.	TLR6 TICAM1	6.12e-05	9	46	2	19543401
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FBRSL1 ANKRD17 CACNA1G EMC1 TEX2 RAI1	6.73e-05	529	46	6	14621295
Pubmed	BCoR, a novel corepressor involved in BCL-6 repression.	NCOR1 BCL6	7.65e-05	10	46	2	10898795
Pubmed	Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.	TLR6 TICAM1	7.65e-05	10	46	2	19122641
Pubmed	Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain.	TLR6 TICAM1	7.65e-05	10	46	2	21098227
Pubmed	Human transcription factor protein interaction networks.	FBRSL1 GON4L ANKRD17 NCOR1 TNRC6C FAM120A ERG NFIX MYBL2	9.07e-05	1429	46	9	35140242
Pubmed	Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury.	TLR6 TICAM1	9.34e-05	11	46	2	23843525
Pubmed	Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord.	ONECUT2 POU4F1	9.34e-05	11	46	2	31787878
Pubmed	CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.	TLR6 TICAM1	9.34e-05	11	46	2	20037584
Pubmed	TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.	TLR6 TICAM1	1.12e-04	12	46	2	26831104
Pubmed	Murine cerebral malaria development is independent of toll-like receptor signaling.	TLR6 TICAM1	1.12e-04	12	46	2	17456769
Pubmed	A shared transcriptional code orchestrates temporal patterning of the central nervous system.	ONECUT2 POU4F1	1.12e-04	12	46	2	34767545
Pubmed	The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.	TLR6 TICAM1	1.12e-04	12	46	2	20495560
Pubmed	ENU-mutagenesis: insight into immune function and pathology.	TLR6 TICAM1	1.32e-04	13	46	2	16889948
Pubmed	Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.	TLR6 TICAM1	1.32e-04	13	46	2	12935356
Pubmed	The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina.	POU4F1 ERG	1.32e-04	13	46	2	29053761
Pubmed	MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.	TLR6 TICAM1	1.54e-04	14	46	2	16886064
Pubmed	Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.	ONECUT2 POU4F1	1.54e-04	14	46	2	22534286
Pubmed	The histone deacetylase 9 gene encodes multiple protein isoforms.	NCOR1 BCL6	1.54e-04	14	46	2	12590135
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	ANKRD17 TNRC6C FAM120A	1.66e-04	80	46	3	35803934
Pubmed	Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1.	ONECUT2 POU4F1	1.78e-04	15	46	2	36924502
Pubmed	MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.	TLR6 TICAM1	1.78e-04	15	46	2	17339472
Pubmed	Integral bHLH factor regulation of cell cycle exit and RGC differentiation.	ONECUT2 POU4F1	1.78e-04	15	46	2	29770538
Pubmed	Natural selection in the TLR-related genes in the course of primate evolution.	TLR6 TICAM1	2.03e-04	16	46	2	18810425
Pubmed	The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development.	ONECUT2 POU4F1	2.03e-04	16	46	2	28603487
Pubmed	Expression of Toll-like receptors in the developing brain.	TLR6 TICAM1	2.03e-04	16	46	2	22666391
Pubmed	A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis.	ONECUT2 POU4F1	2.30e-04	17	46	2	38823017
Pubmed	Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.	KCNH6 BCL6 TLR6 TICAM1	2.49e-04	231	46	4	21048031
Pubmed	Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development.	ONECUT2 POU4F1	2.58e-04	18	46	2	25794677
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ONECUT2 NCOR1 ABCF2 IK NFIX UTP4 RAI1 MYBL2	2.66e-04	1294	46	8	30804502
Pubmed	Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.	BCL6 TLR6	2.88e-04	19	46	2	25681338
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	NCOR1 FAM120A IK TEX2	3.06e-04	244	46	4	29884807
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FBRSL1 GON4L TNRC6C	3.30e-04	101	46	3	10997877
Pubmed	Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.	BCL6 IK	3.54e-04	21	46	2	21509594
Pubmed	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors.	TLR6 TICAM1	3.89e-04	22	46	2	31729371
Pubmed	B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.	POU4F1 SEMA6D	3.89e-04	22	46	2	24733831
Pubmed	TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus.	POU4F1 CACNA1G	3.89e-04	22	46	2	32675279
Pubmed	Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.	TNRC6C ERG	4.25e-04	23	46	2	28811219
Pubmed	BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.	FBRSL1 NCOR1	4.64e-04	24	46	2	33722704
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	GON4L NCOR1 ABCF2 FAM120A BCL6	4.94e-04	497	46	5	23414517
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	NCOR1 CCDC168 PDZD2	5.86e-04	123	46	3	26912792
Pubmed	Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.	PRPSAP2 RAI1	5.88e-04	27	46	2	17273973
Pubmed	Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation.	POU4F1 TCF7L1	5.88e-04	27	46	2	25885041
Pubmed	Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.	ONECUT2 POU4F1	7.27e-04	30	46	2	37048108
Pubmed	Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.	ONECUT2 POU4F1	7.27e-04	30	46	2	30127719
Pubmed	Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons.	ONECUT2 POU4F1	7.27e-04	30	46	2	31399471
Pubmed	Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.	ONECUT2 POU4F1	7.27e-04	30	46	2	29137925
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	PRPSAP2 GON4L ANKRD17 ABCF2 IK	7.61e-04	547	46	5	37267103
Pubmed	Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.	BCL6 TLR6	8.28e-04	32	46	2	23817571
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ANKRD17 FOXR1 NCOR1 FAM120A NFIX MYBL2	8.89e-04	857	46	6	25609649
Pubmed	A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.	ONECUT2 POU4F1	9.90e-04	35	46	2	26988119
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	POU4F1 HIVEP2 BCL6 ERG RAI1 MYBL2	1.00e-03	877	46	6	20211142
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	ABCF2 NFIX UTP4	1.08e-03	152	46	3	16009940
Pubmed	A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain.	ONECUT2 POU4F1	1.17e-03	38	46	2	39106860
Pubmed	Interaction network of human early embryonic transcription factors.	FBRSL1 NCOR1 HIVEP2 RAI1	1.19e-03	351	46	4	38297188
Pubmed	Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.	ANKRD17 HIVEP2	1.23e-03	39	46	2	24556642
Cytoband	17q23.3	KCNH6 TEX2	4.20e-04	30	46	2	17q23.3
Cytoband	Ensembl 112 genes in cytogenetic band chr17p11	PRPSAP2 NCOR1 RAI1	1.12e-03	203	46	3	chr17p11
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	GON4L NCOR1 MYBL2	6.62e-05	53	27	3	532
GeneFamily	SH2 domain containing	BCAR3 SH3BP2	9.90e-03	101	27	2	741
Coexpression	GSE36476_YOUNG_VS_OLD_DONOR_MEMORY_CD4_TCELL_40H_TSST_ACT_DN	GON4L DAP BCAR3 BCL6 ZNF337	2.43e-05	197	46	5	M5322
Coexpression	GSE30971_2H_VS_4H_LPS_STIM_MACROPHAGE_WBP7_KO_UP	NCKAP5 TCF7L1 MAP4K2 SH3BP2 SBF2	2.62e-05	200	46	5	M8703
ToppCell	normal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ\|normal_Lymph_Node / Location, Cell class and cell subclass	PRPSAP2 QPCT ECEL1 BCAR3 MYBL2	1.10e-06	178	46	5	d75057e7463558a0d3cebde3c30befbf4704dd9a
ToppCell	COVID-19_Mild-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	CCDC168 SEMA6D TCF7L1 EXPH5	8.20e-06	124	46	4	5ef9eb806fb2c8ee5aae0a75503d244b08ee10d4
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 GON4L CACNA1G EXPH5	1.15e-05	135	46	4	c4d3c9eba2a85ac40fea5ecfcc2b442a472323d0
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BCL6 SH3BP2 TICAM1 MYBL2	3.04e-05	173	46	4	12c6875f881cb0fbff09d753b53c1cce7a95527f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH6 NCKAP5 SH3BP2 PDZD2	3.04e-05	173	46	4	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH6 NCKAP5 SH3BP2 PDZD2	3.32e-05	177	46	4	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH6 NCKAP5 SH3BP2 PDZD2	3.55e-05	180	46	4	f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NCKAP5 ERG SEMA6D NFIX	3.95e-05	185	46	4	9f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NCKAP5 CACNA1G ERG SEMA6D	3.95e-05	185	46	4	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH6 NCKAP5 SH3BP2 PDZD2	4.03e-05	186	46	4	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH6 NCKAP5 SH3BP2 PDZD2	4.11e-05	187	46	4	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	normal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ\|B_lymphocytes / Location, Cell class and cell subclass	PRPSAP2 QPCT BCAR3 MYBL2	4.11e-05	187	46	4	457eb3791a8c5458d81833e0701ac5a9bfdee2bf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH6 NCKAP5 SH3BP2 PDZD2	4.11e-05	187	46	4	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	mild-Myeloid-Immature_Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MINAR1 ENPP4 ERG TEX2	4.29e-05	189	46	4	94dd5d4d815449feff7ce157fe7f8234f7c81422
ToppCell	control-Myeloid-Immature_Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MINAR1 ENPP4 ERG TEX2	4.56e-05	192	46	4	9f12b79d661ef0f57c2c924e8ecc24a46ea996d2
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD17 NCKAP5 SBF2 PDZD2	4.56e-05	192	46	4	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NCKAP5 ERG TCF7L1 SBF2	4.65e-05	193	46	4	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DOCK3 ENPP4 EXPH5 IFNLR1	4.75e-05	194	46	4	c5ef4ff73b4e51530656002e3a2fb7264cdf533d
ToppCell	Sepsis-ICU-SEP-Myeloid-pDC\|ICU-SEP / Disease, condition lineage and cell class	POU4F1 MINAR1 BCAR3 MYBL2	5.14e-05	198	46	4	fe8a68bff8c1b9566eee4bfcab564f206a20ae7b
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	MINAR1 CCDC168 TCF7L1 MYBL2	5.24e-05	199	46	4	e222b90caf45904d8f763574e7b6aac13333df92
Drug	WAY-123,398	KCNH6 ERG IK	9.17e-07	10	46	3	CID000132160
Drug	sulfasalazine; Up 200; 100uM; MCF7; HG-U133A	NCOR1 ABCF2 HIVEP2 BCL6 SEMA6D TCF7L1	2.73e-06	197	46	6	204_UP
Drug	MK-499	KCNH6 ERG IK	7.31e-06	19	46	3	CID000127718
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A	QPCT ONECUT2 POU4F1 ZNF337 EXPH5	3.79e-05	188	46	5	6143_UP
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	ONECUT2 ABCF2 POU4F1 EMC1 SH3BP2	4.51e-05	195	46	5	4358_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A	ONECUT2 GON4L SEMA6D MAP4K2 SH3BP2	4.74e-05	197	46	5	6060_DN
Drug	Diloxanide furoate [3736-81-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	QPCT ABCF2 EMC1 MAP4K2 TICAM1	4.74e-05	197	46	5	3399_DN
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	QPCT NCOR1 ABCF2 EMC1 EXPH5	4.74e-05	197	46	5	5236_DN
Drug	Dydrogesterone [152-62-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A	ONECUT2 ABCF2 POU4F1 EMC1 TICAM1	4.85e-05	198	46	5	2811_UP
Drug	Phensuximide [86-34-0]; Down 200; 21.2uM; MCF7; HT_HG-U133A	ONECUT2 ABCF2 BCL6 ZNF337 EXPH5	4.85e-05	198	46	5	5522_DN
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; HL60; HT_HG-U133A	QPCT GON4L BCL6 ZNF337 SH3BP2	4.85e-05	198	46	5	2352_DN
Drug	Dipivefrin hydrochloride [64019-93-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A	ONECUT2 GON4L HIVEP2 SH3BP2 TICAM1	4.97e-05	199	46	5	2744_DN
Drug	Justin E	QPCT UTP4	5.96e-05	6	46	2	CID000402923
Disease	triglyceride measurement, coronary artery disease	FBRSL1 MAP4K2	1.36e-05	4	45	2	EFO_0001645, EFO_0004530
Disease	reaction time measurement	FBRSL1 NCKAP5 TNRC6C SEMA6D NFIX RAI1	4.67e-04	658	45	6	EFO_0008393
Disease	Alzheimer disease, educational attainment	DOCK3 BCAR3 SEMA6D NFIX	5.45e-04	247	45	4	EFO_0011015, MONDO_0004975
Disease	hematocrit	FBRSL1 ANKRD17 HIVEP2 BCL6 ERG SBF2 RAI1	7.90e-04	1011	45	7	EFO_0004348
Disease	pulse pressure measurement	FBRSL1 POC5 ERG IK TEX2 TCF7L1 MAP4K2 SBF2	1.09e-03	1392	45	8	EFO_0005763
Disease	Mental Retardation, Psychosocial	GON4L CACNA1G RAI1	1.26e-03	139	45	3	C0025363
Disease	Profound Mental Retardation	GON4L CACNA1G RAI1	1.26e-03	139	45	3	C0020796
Disease	Mental deficiency	GON4L CACNA1G RAI1	1.26e-03	139	45	3	C0917816
Disease	major depressive disorder	HIVEP2 FAM120A SEMA6D	1.72e-03	155	45	3	MONDO_0002009
Disease	cognitive inhibition measurement	HIVEP2 SEMA6D	2.66e-03	50	45	2	EFO_0007969
Disease	coffee consumption measurement	FAM120A SH3BP2 RAI1	2.71e-03	182	45	3	EFO_0006781
Disease	body weight	GON4L NCOR1 POC5 HIVEP2 BCL6 SEMA6D PDZD2	2.80e-03	1261	45	7	EFO_0004338
Disease	Chronic Lymphocytic Leukemia	QPCT BCL6	3.21e-03	55	45	2	C0023434

Protein segments in the cluster

Peptide	Gene	Start	Entry
HPATFPTRMHLKTEP	AHRR	566	A9YTQ3
AAKMPARASPPHSKA	FBRSL1	836	Q9HCM7
KPHASMDKHPSPRTQ	DAP	81	P51397
HLTREMPPSDKTPLH	ABCF2	146	Q9UG63
DFSHMGTLPHSKSPR	BCAR3	66	O75815
YPNTRLPTSHMPSHL	ERG	461	P11308
TPRKPAFSDMPRAHS	SH3BP2	211	P78314
RATNSPKPHMVPRHS	ANKRD17	1936	O75179
ITDHSHFMPLLNPSP	RAI1	386	Q7Z5J4
SRHLAAKMASTPHPP	QPCT	216	Q16769
RSSCHGLPPTPKVHM	MAP4K2	456	Q12851
SKQPHFAMHPTLPEH	POU4F1	6	Q01851
RKPSHPVMDFFSSHL	POC5	111	Q8NA72
SPRMAFTHHPLPVLA	NFIX	341	Q14938
AKMPRALDFSGHTHP	IFNLR1	261	Q8IU57
HAFPPPRTALSHSKM	SBF2	336	Q86WG5
DCSPKHRNSSPRMPH	KCNH6	906	Q9H252
RHFHSPPIILSSPNM	PDZD2	1716	O15018
SLPSMHPFLAAHGPA	ENPP4	341	Q9Y6X5
PLHHAMSMSCDSSPP	ONECUT2	126	O95948
IFPNKPASHPMRSHT	EXPH5	656	Q8NEV8
TSKPMSFHPPHYLAA	FAM120A	331	Q9NZB2
RAFHCPKDSPMNPAH	ECEL1	756	O95672
PMSPESIKMTHRHSP	DOCK3	1656	Q8IZD9
HEMKSPPSARSSPHS	CACNA1G	1081	O43497
SSSMALPSPHKRAPL	FOXR1	141	Q6PIV2
MKPAPVIHHPASVIF	GON4L	1131	Q3T8J9
SSESHSPLYMHPPKC	BCL6	461	P41182
YPFSHSMKPHLHPRL	LYG2	21	Q86SG7
HSPPMVRSVAAIHPS	PRPSAP2	226	O60256
KLMVQRTTAHFPHPP	EMC1	571	Q8N766
MPSLSHHRFSPSQPK	CCDC168	4831	Q8NDH2
HPYPASLKAHMKSNP	MINAR1	796	Q9UPX6
TPITHISFHPKRPMH	UTP4	581	Q969X6
PPHLSLHPSAGKSAM	TNRC6C	1221	Q9HCJ0
PKHSAQLPHSSRMPS	NCKAP5	866	O14513
AQKPRSHFTTPAPMS	MYBL2	646	P10244
RSHLPTHLDPAMPFH	NCOR1	1561	O75376
SRFSPHMVAPAHPGL	TCF7L1	286	Q9HCS4
QSPTMPFLSLHRSPH	TICAM1	211	Q8IUC6
APTSAPPSKSRHHEM	IK	46	Q13123
TPFIHMLCPHAPSTF	TLR6	341	Q9Y2C9
MSPTKDSHPSPHFPR	nan	1	Q6ZRN7
PKESPHPARHRHLMK	TEX2	201	Q8IWB9
MVHSMPPALSSLHPS	HIVEP2	2236	P31629
SFIKSHPLMDSAVPP	SEMA6D	391	Q8NFY4
STKPMAFSSPPLRHA	ZNF337	126	Q9Y3M9