Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	U6 snRNA binding	SART3 PRPF4 PRPF8	1.40e-05	18	53	3	GO:0017070
GeneOntologyMolecularFunction	U4 snRNA binding	SART3 PRPF4	2.46e-04	9	53	2	GO:0030621
GeneOntologyMolecularFunction	calcium channel activity	STIM2 TRPV4 TRPM8 PKDREJ	3.81e-04	129	53	4	GO:0005262
GeneOntologyMolecularFunction	snRNA binding	SART3 PRPF4 PRPF8	4.67e-04	57	53	3	GO:0017069
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	STIM2 TRPV4 TRPM8 PKDREJ	6.90e-04	151	53	4	GO:0015085
GeneOntologyMolecularFunction	5'-nucleotidase activity	NT5DC4 NT5C	7.10e-04	15	53	2	GO:0008253
GeneOntologyMolecularFunction	nucleotidase activity	NT5DC4 NT5C	1.03e-03	18	53	2	GO:0008252
GeneOntologyCellularComponent	spectrin	SPTA1 SPTBN1 PRKCB	1.14e-06	9	51	3	GO:0008091
GeneOntologyCellularComponent	U4/U6 snRNP	SART3 PRPF4	1.75e-05	3	51	2	GO:0071001
GeneOntologyCellularComponent	cortical actin cytoskeleton	SPTA1 SPTBN1 PRKCB TRPV4	7.82e-05	93	51	4	GO:0030864
GeneOntologyCellularComponent	small nuclear ribonucleoprotein complex	SART3 PRPF4 GEMIN4 PRPF8	1.35e-04	107	51	4	GO:0030532
GeneOntologyCellularComponent	Sm-like protein family complex	SART3 PRPF4 GEMIN4 PRPF8	2.03e-04	119	51	4	GO:0120114
GeneOntologyCellularComponent	U4/U6 x U5 tri-snRNP complex	SART3 PRPF4 PRPF8	2.06e-04	47	51	3	GO:0046540
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTA1 SPTBN1	2.08e-04	9	51	2	GO:0014731
GeneOntologyCellularComponent	spliceosomal tri-snRNP complex	SART3 PRPF4 PRPF8	2.19e-04	48	51	3	GO:0097526
GeneOntologyCellularComponent	cortical cytoskeleton	SPTA1 SPTBN1 PRKCB TRPV4	2.76e-04	129	51	4	GO:0030863
GeneOntologyCellularComponent	cuticular plate	SPTA1 SPTBN1	4.47e-04	13	51	2	GO:0032437
GeneOntologyCellularComponent	Cajal body	SART3 PRPF4 GEMIN4	1.13e-03	84	51	3	GO:0015030
GeneOntologyCellularComponent	Sin3-type complex	MORF4L1 BRMS1	1.31e-03	22	51	2	GO:0070822
GeneOntologyCellularComponent	spliceosomal snRNP complex	SART3 PRPF4 PRPF8	1.67e-03	96	51	3	GO:0097525
GeneOntologyCellularComponent	actin cytoskeleton	SPTA1 SPTBN1 PRKCB TRPV4 ACTRT2 ACTL9	2.68e-03	576	51	6	GO:0015629
GeneOntologyCellularComponent	NuA4 histone acetyltransferase complex	MORF4L1 ACTL9	2.76e-03	32	51	2	GO:0035267
GeneOntologyCellularComponent	H4/H2A histone acetyltransferase complex	MORF4L1 ACTL9	2.76e-03	32	51	2	GO:0043189
Domain	NHR2	CBFA2T2 RUNX1T1 CBFA2T3	2.04e-08	3	52	3	IPR014896
Domain	NHR2	CBFA2T2 RUNX1T1 CBFA2T3	2.04e-08	3	52	3	PF08788
Domain	CBFA2T1/2/3	CBFA2T2 RUNX1T1 CBFA2T3	2.04e-08	3	52	3	IPR013289
Domain	TAFH	CBFA2T2 RUNX1T1 CBFA2T3	2.03e-07	5	52	3	SM00549
Domain	TAFH	CBFA2T2 RUNX1T1 CBFA2T3	2.03e-07	5	52	3	PS51119
Domain	TAFH	CBFA2T2 RUNX1T1 CBFA2T3	2.03e-07	5	52	3	PF07531
Domain	TAFH_NHR1	CBFA2T2 RUNX1T1 CBFA2T3	2.03e-07	5	52	3	IPR003894
Domain	zf-MYND	CBFA2T2 RUNX1T1 CBFA2T3	2.61e-05	21	52	3	PF01753
Domain	Znf_MYND	CBFA2T2 RUNX1T1 CBFA2T3	3.02e-05	22	52	3	IPR002893
Domain	ZF_MYND_1	CBFA2T2 RUNX1T1 CBFA2T3	3.02e-05	22	52	3	PS01360
Domain	ZF_MYND_2	CBFA2T2 RUNX1T1 CBFA2T3	3.02e-05	22	52	3	PS50865
Domain	Spectrin	TRIO SPTA1 SPTBN1	3.47e-05	23	52	3	PF00435
Domain	Spectrin_repeat	TRIO SPTA1 SPTBN1	7.07e-05	29	52	3	IPR002017
Domain	Spectrin/alpha-actinin	TRIO SPTA1 SPTBN1	9.54e-05	32	52	3	IPR018159
Domain	SPEC	TRIO SPTA1 SPTBN1	9.54e-05	32	52	3	SM00150
Domain	PH_dom-spectrin-type	SPTBN1 PSD4	2.70e-04	9	52	2	IPR001605
Domain	SH3_1	TRIO SPTA1 NCF1 PPP1R13B	1.12e-03	164	52	4	PF00018
Domain	SH3	TRIO SPTA1 NCF1 PPP1R13B	3.05e-03	216	52	4	SM00326
Domain	SH3	TRIO SPTA1 NCF1 PPP1R13B	3.05e-03	216	52	4	PS50002
Domain	SH3_domain	TRIO SPTA1 NCF1 PPP1R13B	3.26e-03	220	52	4	IPR001452
Domain	Actin	ACTRT2 ACTL9	3.36e-03	31	52	2	IPR004000
Domain	Actin	ACTRT2 ACTL9	3.36e-03	31	52	2	PF00022
Domain	ACTIN	ACTRT2 ACTL9	3.36e-03	31	52	2	SM00268
Domain	Ank	ASB16 HACE1 PPP1R13B TRPV4	3.70e-03	228	52	4	PF00023
Domain	EF_HAND_2	CAPN9 STIM2 SPTA1 TBC1D8B	3.88e-03	231	52	4	PS50222
Domain	Ion_trans_dom	KCNH8 TRPV4 TRPM8	3.94e-03	114	52	3	IPR005821
Domain	Ion_trans	KCNH8 TRPV4 TRPM8	3.94e-03	114	52	3	PF00520
Domain	-	ASB16 HACE1 PPP1R13B TRPV4	4.99e-03	248	52	4	1.25.40.20
Domain	ANK	ASB16 HACE1 PPP1R13B TRPV4	5.20e-03	251	52	4	SM00248
Domain	ANK_REPEAT	ASB16 HACE1 PPP1R13B TRPV4	5.35e-03	253	52	4	PS50088
Domain	Ankyrin_rpt-contain_dom	ASB16 HACE1 PPP1R13B TRPV4	5.42e-03	254	52	4	IPR020683
Domain	ANK_REP_REGION	ASB16 HACE1 PPP1R13B TRPV4	5.42e-03	254	52	4	PS50297
Pubmed	CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.	CBFA2T2 RUNX1T1 CBFA2T3	3.34e-09	3	53	3	9790752
Pubmed	ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.	CBFA2T2 RUNX1T1 CBFA2T3	1.34e-08	4	53	3	16966434
Pubmed	Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins.	CBFA2T2 RUNX1T1 CBFA2T3	1.34e-08	4	53	3	14703694
Pubmed	Regional expression of MTG genes in the developing mouse central nervous system.	CBFA2T2 RUNX1T1 CBFA2T3	3.33e-08	5	53	3	19618476
Pubmed	Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.	CBFA2T2 RUNX1T1 CBFA2T3	3.33e-08	5	53	3	18586123
Pubmed	Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription.	CBFA2T2 RUNX1T1 CBFA2T3	3.33e-08	5	53	3	18039847
Pubmed	Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.	CBFA2T2 RUNX1T1 CBFA2T3	6.66e-08	6	53	3	23251453
Pubmed	The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.	CBFA2T2 RUNX1T1 CBFA2T3	1.16e-07	7	53	3	12242670
Pubmed	PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.	CBFA2T2 RUNX1T1 CBFA2T3	3.98e-07	10	53	3	22498736
Pubmed	Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway.	CBFA2T2 RUNX1T1 CBFA2T3	1.85e-06	16	53	3	25077969
Pubmed	Vascular endothelial growth factor-D modulates oxidant-antioxidant balance of human vascular endothelial cells.	MTOR VEGFD	2.28e-06	2	53	2	27957793
Pubmed	Roles for beta II-protein kinase C and RACK1 in positive and negative signaling for superoxide anion generation in differentiated HL60 cells.	NCF1 PRKCB	2.28e-06	2	53	2	11120743
Pubmed	The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea.	TRPV4 TRPM8	2.28e-06	2	53	2	36517318
Pubmed	The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells.	CBFA2T2 CBFA2T3	2.28e-06	2	53	2	22443175
Pubmed	Conformational change of erythroid alpha-spectrin at the tetramerization site upon binding beta-spectrin.	SPTA1 SPTBN1	2.28e-06	2	53	2	17905835
Pubmed	ETO-2, a new member of the ETO-family of nuclear proteins.	RUNX1T1 CBFA2T3	2.28e-06	2	53	2	10022820
Pubmed	Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.	CBFA2T2 RUNX1T1	6.83e-06	3	53	2	10675041
Pubmed	CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions.	RUNX1T1 CBFA2T3	6.83e-06	3	53	2	38243303
Pubmed	Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins.	TRPV4 TRPM8	6.83e-06	3	53	2	29175331
Pubmed	Myeloid translocation genes differentially regulate colorectal cancer programs.	CBFA2T2 CBFA2T3	6.83e-06	3	53	2	27270437
Pubmed	Interferon gamma boosts the nucleotide oligomerization domain 2-mediated signaling pathway in human dendritic cells in an X-linked inhibitor of apoptosis protein and mammalian target of rapamycin-dependent manner.	MTOR NOD2	6.83e-06	3	53	2	26521691
Pubmed	Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.	TRPV4 TRPM8	6.83e-06	3	53	2	26207981
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	IPO5 SART3 URB1 CORO2A MTOR SPTBN1 NCF1 GEMIN4 PRPF8 LCLAT1 NOD2	9.06e-06	1440	53	11	30833792
Pubmed	Transcriptional landscape of TRPV1, TRPA1, TRPV4, and TRPM8 channels throughout human tissues.	TRPV4 TRPM8	1.36e-05	4	53	2	36126722
Pubmed	Failure of human rhombic lip differentiation underlies medulloblastoma formation.	CBFA2T2 CBFA2T3	1.36e-05	4	53	2	36131014
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTA1 SPTBN1	1.36e-05	4	53	2	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTA1 SPTBN1	1.36e-05	4	53	2	3862089
Pubmed	The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.	CBFA2T2 CBFA2T3	1.36e-05	4	53	2	9447981
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTA1 SPTBN1	1.36e-05	4	53	2	21412925
Pubmed	Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy.	TRPV4 TRPM8	1.36e-05	4	53	2	17521436
Pubmed	Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer.	SART3 PRPF4	1.36e-05	4	53	2	15452143
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTA1 SPTBN1	1.36e-05	4	53	2	12820899
Pubmed	TRPA1 is essential for the vascular response to environmental cold exposure.	TRPV4 TRPM8	1.36e-05	4	53	2	25501034
Pubmed	Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.	SART3 PRPF4 PRPF8	1.46e-05	31	53	3	28878014
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPV4 TRPM8 PKDREJ	1.77e-05	33	53	3	19834762
Pubmed	Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.	CBFA2T2 RUNX1T1	2.27e-05	5	53	2	16227606
Pubmed	The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes.	PRPF4 PRPF8	2.27e-05	5	53	2	11350945
Pubmed	Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst.	NCF1 PRKCB	2.27e-05	5	53	2	11145703
Pubmed	A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways.	NCF1 NOD2	2.27e-05	5	53	2	23322906
Pubmed	Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior.	TRPV4 TRPM8	2.27e-05	5	53	2	30842533
Pubmed	T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.	SPTA1 SPTBN1	2.27e-05	5	53	2	29720258
Pubmed	Analysis of erythrocyte and platelet membrane proteins in various forms of beta-thalassemia.	SPTA1 SPTBN1	3.40e-05	6	53	2	15310273
Pubmed	USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31.	SART3 PRPF8	3.40e-05	6	53	2	28088760
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPV4 TRPM8 PKDREJ	4.23e-05	44	53	3	19322198
Pubmed	Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation.	NCF1 PRKCB	4.76e-05	7	53	2	12056906
Pubmed	Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors.	CBFA2T2 CBFA2T3	4.76e-05	7	53	2	19799863
Pubmed	Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150.	TRPV4 TRPM8	4.76e-05	7	53	2	18701070
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	IPO5 SART3 PRPF4 MTOR SPTBN1 GEMIN4 PRPF8	5.02e-05	638	53	7	33239621
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IPO5 SART3 URB1 MTOR SPTBN1 GEMIN4 PRPF8	5.80e-05	653	53	7	22586326
Pubmed	The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.	NCF1 PRKCB	6.34e-05	8	53	2	8089108
Pubmed	ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.	RUNX1T1 CBFA2T3	6.34e-05	8	53	2	11533236
Pubmed	The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.	SART3 PRPF8	6.34e-05	8	53	2	20595234
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	IPO5 TRIO SPTBN1 PPP1R13B	8.47e-05	151	53	4	17043677
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTA1 SPTBN1	1.02e-04	10	53	2	22159418
Pubmed	A B-Myb complex containing clathrin and filamin is required for mitotic spindle function.	SPTA1 SPTBN1	1.02e-04	10	53	2	18548008
Pubmed	Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP.	PRPF4 PRPF8	1.24e-04	11	53	2	21283520
Pubmed	The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells.	PRPF4 PRPF8	1.49e-04	12	53	2	23793891
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	IPO5 TRIO CORO2A SPTBN1 PRPF8	1.52e-04	332	53	5	37433992
Pubmed	The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.	PRPF4 PRPF8	1.76e-04	13	53	2	16723661
Pubmed	Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions.	PRPF4 PRPF8	2.05e-04	14	53	2	11971955
Pubmed	E protein silencing by the leukemogenic AML1-ETO fusion protein.	CBFA2T2 RUNX1T1	2.05e-04	14	53	2	15333839
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	IPO5 TRIO MTOR PRPF8	2.59e-04	202	53	4	33005030
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IPO5 SART3 URB1 TRIO PRPF4 MTOR SPTBN1 GEMIN4 PRPF8	2.76e-04	1425	53	9	30948266
Pubmed	TIF1gamma controls erythroid cell fate by regulating transcription elongation.	RUNX1T1 CBFA2T3	3.43e-04	18	53	2	20603019
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTA1 SPTBN1	3.43e-04	18	53	2	12119179
Pubmed	Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.	TRPV4 TRPM8	3.43e-04	18	53	2	31911949
Pubmed	Defining the membrane proteome of NK cells.	IPO5 MTOR GEMIN4 PRPF8 LMBRD1 RUSF1 LCLAT1 PSD4	3.66e-04	1168	53	8	19946888
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	IPO5 URB1 SPTBN1 GEMIN4 PRPF8	3.92e-04	408	53	5	33766124
Pubmed	ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.	CBFA2T2 CBFA2T3	4.25e-04	20	53	2	16407974
Pubmed	Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.	SPTA1 SPTBN1	4.25e-04	20	53	2	18723693
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	IPO5 CRELD1 MORF4L1 SPTBN1 GEMIN4 PRPF8 RUSF1 LCLAT1	4.45e-04	1203	53	8	29180619
Pubmed	Affinity purification strategies for proteomic analysis of transcription factor complexes.	CORO2A PRPF4 PRPF8	4.45e-04	97	53	3	23937658
Pubmed	Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis.	MTOR VEGFD	4.70e-04	21	53	2	19710174
Pubmed	Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.	MTOR LMBRD1	5.16e-04	22	53	2	26166573
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	IPO5 SPTBN1 PRPF8	5.46e-04	104	53	3	36055981
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	URB1 PRPF4 SPTBN1	5.46e-04	104	53	3	26167872
Pubmed	Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.	GEMIN4 PRPF8	5.65e-04	23	53	2	20696395
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPV4 TRPM8	6.16e-04	24	53	2	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPV4 TRPM8	6.68e-04	25	53	2	16382100
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTA1 SPTBN1	6.68e-04	25	53	2	8493579
Pubmed	An introduction to TRP channels.	TRPV4 TRPM8	7.80e-04	27	53	2	16460286
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	IPO5 MTOR PRPF8	8.27e-04	120	53	3	27320910
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	TRIO SPTBN1 PPP1R13B	8.27e-04	120	53	3	31413325
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	TRIO MTOR SPTBN1 PRKCB	8.95e-04	281	53	4	28706196
Pubmed	Mechanism of 5' splice site transfer for human spliceosome activation.	PRPF4 PRPF8	9.01e-04	29	53	2	30975767
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	CBFA2T2 CBFA2T3	9.64e-04	30	53	2	26593974
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	SART3 PRPF4 GEMIN4 PRPF8	1.14e-03	300	53	4	28561026
Pubmed	Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.	PRPF4 PRPF8	1.17e-03	33	53	2	28781166
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	CORO2A SPTA1 SPTBN1	1.48e-03	147	53	3	16959763
Cytoband	12q24.1	SART3 TRPV4	1.36e-04	15	53	2	12q24.1
Cytoband	1p36.32	PEX10 ACTRT2	3.26e-04	23	53	2	1p36.32
Cytoband	2q13	NT5DC4 PSD4	2.84e-03	68	53	2	2q13
GeneFamily	Zinc fingers MYND-type	CBFA2T2 RUNX1T1 CBFA2T3	1.02e-05	21	37	3	87
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTBN1	8.50e-05	7	37	2	1113
GeneFamily	Ankyrin repeat domain containing	ASB16 HACE1 PPP1R13B TRPV4	1.46e-03	242	37	4	403
GeneFamily	Transient receptor potential cation channels	TRPV4 TRPM8	1.49e-03	28	37	2	249
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	GEMIN4 LY75	4.88e-03	51	37	2	870
GeneFamily	EF-hand domain containing	CAPN9 SPTA1 TBC1D8B	1.01e-02	219	37	3	863
GeneFamily	Sterile alpha motif domain containing	STIM2 PPFIBP2	1.40e-02	88	37	2	760
GeneFamily	WD repeat domain containing	CORO2A PRPF4 DYNC2I1	1.63e-02	262	37	3	362
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	KCNH8 TRIO PPFIBP2 PRKCB CBFA2T3	2.87e-06	187	53	5	af1327559f7e01bec070881cae52834917c3da65
ToppCell	PND07-Immune-Immune_Myeloid-DC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO2A NCF1 CBFA2T3 LY75	2.83e-05	147	53	4	bbc52cbea37a38058436e3fc6fc0777f83404524
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO2A NCF1 TRPV4 CBFA2T3	3.39e-05	154	53	4	c663e9834be0b45389a862dc3c13a1f988a3e5ee
ToppCell	facs-MAT-Fat-3m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A PPFIBP2 NCF1 CBFA2T3	4.34e-05	164	53	4	b81498c3934e0d52bf0329dc745e02966f9d8613
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH8 NCF1 PRKCB CBFA2T3	5.71e-05	176	53	4	d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH8 NCF1 PRKCB CBFA2T3	5.71e-05	176	53	4	274458d80f9f3f080248cbf64e4784ef351e7254
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH8 NCF1 PRKCB CBFA2T3	5.83e-05	177	53	4	b07e6139618d888a9fd7cf43cad0d86a3f63e09e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH8 NCF1 PRKCB CBFA2T3	5.83e-05	177	53	4	6376ec12322c04d5d37ec2fdc376700464cbc7fb
ToppCell	Children_(3_yrs)-Immune-B_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KCNH8 NCF1 PRKCB CBFA2T3	6.09e-05	179	53	4	31411780f1a44bf2d102f288416e97eacec4b6b6
ToppCell	COVID-19-kidney-Bcells\|kidney / Disease (COVID-19 only), tissue and cell type	KCNH8 NCF1 PRKCB CBFA2T3	6.23e-05	180	53	4	5650fc7ebcdf5e0be9a217a58d36a8386d59fd1b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH8 NCF1 PRKCB CBFA2T3	6.23e-05	180	53	4	65c069585737302a69b9a01476f4eb8b50cb2bfd
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL ATAD5 SPTBN1 LY75	6.50e-05	182	53	4	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL ATAD5 SPTBN1 LY75	6.50e-05	182	53	4	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH8 NCF1 PRKCB CBFA2T3	6.78e-05	184	53	4	f81209e6bc01a0140f4487aa8b22eb02fbf0c39c
ToppCell	cellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KCNH8 NCF1 PRKCB CBFA2T3	7.07e-05	186	53	4	d23c3318937492d7d665bec14253124c49181b5a
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	STIM2 KCNH8 PPFIBP2 PRKCB	7.07e-05	186	53	4	55b239834b96b1f7787ec77a7d19796d617bbbf0
ToppCell	Control-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	KCNH8 TRIO PPFIBP2 CBFA2T3	7.22e-05	187	53	4	4e64be635f445276e71f2937f33f041c3a4204ab
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH8 NCF1 PRKCB CBFA2T3	7.22e-05	187	53	4	edad646d5eb1d70b768dc21fe02ef5265214e8e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH8 NCF1 PRKCB CBFA2T3	7.22e-05	187	53	4	8fa454dc4e6a3e8e2bb2ad803acc579e0d3f76da
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	KCNH8 TRIO PPFIBP2 CBFA2T3	7.68e-05	190	53	4	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	proximal-Hematologic-Plasmacytoid_Dendritic\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNH8 NCF1 PRKCB CBFA2T3	7.99e-05	192	53	4	faead5875a54fe8f1848ae36008aae4c0f7cb1c7
ToppCell	proximal-3-Hematologic-Plasmacytoid_Dendritic\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNH8 NCF1 PRKCB CBFA2T3	7.99e-05	192	53	4	86938c7d2bb1a7afb2b83828ca33dd137d366ec6
ToppCell	Nasal_Brush-Immune-Neutrophils\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	IFFO1 NCF1 PRKCB CBFA2T3	7.99e-05	192	53	4	20a7f7beb01df1c4f915ec2f9b5a9dbcab157187
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORO2A NCF1 CBFA2T3 LY75	7.99e-05	192	53	4	8b4bbbadeac70f65378697120c754f10501b5651
ToppCell	proximal-Hematologic-Plasmacytoid_Dendritic-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNH8 NCF1 PRKCB CBFA2T3	7.99e-05	192	53	4	e3be395a995dc8c0ebdae754057cfa59a270cae0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NCF1 PRKCB CBFA2T3 NOD2	8.15e-05	193	53	4	3e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRKCB RUNX1T1 VEGFD LCLAT1	8.32e-05	194	53	4	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NCF1 PRKCB CBFA2T3 NOD2	8.32e-05	194	53	4	badefcec2af86cbcd97305f4843e84db0f3ebc66
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SPTBN1 PRKCB RUNX1T1 VEGFD	8.32e-05	194	53	4	a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCell	control-Lymphocytic-B_cells_1\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	KCNH8 TRIO PRKCB CBFA2T3	8.49e-05	195	53	4	ff7956624b36df34e55295b295a71585accf07bd
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	KCNH8 NCF1 PRKCB CBFA2T3	8.49e-05	195	53	4	fbc324c3435f32b9ca269d83333faecfe940d7fe
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNH8 NCF1 PRKCB CBFA2T3	8.49e-05	195	53	4	3311a1bf4ed94820b45047d44fc14b14ac72e6fb
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PPP1R13B PRKCB LCLAT1 PSD4	8.65e-05	196	53	4	c57a95f8b4d8d6334f269d3c16246684f4222a3e
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNH8 NCF1 PRKCB CBFA2T3	8.83e-05	197	53	4	da61afba697ec49ca86e062d35a825280da558ac
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NCF1 PRKCB CBFA2T3 NOD2	8.83e-05	197	53	4	57dafb3047745a44b2345b8036e159c3641d496e
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SPTBN1 PRKCB RUNX1T1 VEGFD	8.83e-05	197	53	4	31a1852911bda38543916585fda34255fd62a134
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNH8 NCF1 PRKCB CBFA2T3	8.83e-05	197	53	4	0f489d26e4013d1b5a90559856ed2de32a0bb772
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SPTBN1 PRKCB RUNX1T1 VEGFD	8.83e-05	197	53	4	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SPTBN1 PRKCB RUNX1T1 VEGFD	8.83e-05	197	53	4	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NCF1 PRKCB CBFA2T3 NOD2	9.00e-05	198	53	4	623f9d64c9e800d2d7f623392bf2f22b563f0249
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	URB1 KCNH8 TRPV4 TBC1D8B	9.36e-05	200	53	4	ed093626a9cac7531a2bf02f6e345c5e84b8c060
Drug	Antibiotic Ps 6	MTOR CBFA2T2 SPTBN1 VEGFD	2.49e-06	41	53	4	CID000166290
Drug	2,3,5-trinitronaphthalene	NT5C NOD2	5.32e-06	2	53	2	CID000055653
Drug	Flutamide [13311-84-7]; Up 200; 14.4uM; MCF7; HT_HG-U133A	URB1 SPTBN1 PRKCB TRPM8 VEGFD NOD2	6.18e-06	196	53	6	4361_UP
Drug	Nalbuphine hydrochloride [23277-43-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A	ATAD5 MTOR CBFA2T2 SPTBN1 DYNC2I1 RUSF1	6.55e-06	198	53	6	7177_DN
Drug	acetaldehyde	CAPN9 MTOR SPTA1 PRKCB ACTRT2 PRPF8 DERA	1.28e-05	338	53	7	CID000000177
Disease	amenorrhea, response to antineoplastic agent	PPCDC DERA	3.27e-04	15	53	2	EFO_0010269, GO_0097327
Disease	Antimigraine preparation use measurement	TRPM8 RUNX1T1	6.50e-04	21	53	2	EFO_0009939
Disease	sensory peripheral neuropathy, remission	RUNX1T1 LMBRD1	7.82e-04	23	53	2	EFO_0009785, MONDO_0002321
Disease	response to peginterferon alfa-2a	CORO2A DERA	9.25e-04	25	53	2	EFO_0010103
Disease	retinitis pigmentosa (implicated_via_orthology)	PRPF4 PRPF8	1.08e-03	27	53	2	DOID:10584 (implicated_via_orthology)
Disease	melanoma	CBFA2T2 TRPM8 CBFA2T3	1.52e-03	126	53	3	EFO_0000756
Disease	hypertension (implicated_via_orthology)	NPR1 MTOR PRKCB	1.59e-03	128	53	3	DOID:10763 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LHSWLKDWKRRAELE	ATAD5	1076	Q96QE3
TGWDDVERLWKHLFE	ACTRT2	81	Q8TDY3
VERLWKHLFEWELGV	ACTRT2	86	Q8TDY3
DWDAAELIWRHLLEH	ACTL9	121	Q8TC94
TWVEAVLPELWKEHE	ASB16	381	Q96NS5
LWEEEKALWVEERAL	CCDC70	156	Q6NSX1
KELASELWRVRWEDV	NPR1	501	P16066
LTILRRKDESETEWW	PPP1R13B	1046	Q96KQ4
LSWSDNWREILDSKR	NT5C	181	Q8TCD5
EELKPWLVDDWDLIT	MORF4L1	201	Q9UBU8
KWLEWRKEVELLSDV	PEX10	41	O60683
HRLLELSEELVESWW	CRELD1	106	Q96HD1
IDHRLTDREWAEEWK	RUNX1T1	341	Q06455
TDREWAEEWKHLDHL	RUNX1T1	346	Q06455
KRERHLEFIENSWWT	LMBRD1	281	Q9NUN5
SKEDLQLWCHKRWEE	LCLAT1	296	Q6UWP7
DTWKADDLRKHLWAI	DYNC2I1	11	Q8WVS4
DHRLTEREWADEWKH	CBFA2T2	336	O43439
EAVEVIHKLLDGWWV	NCF1	251	P14598
ELLWHSLDEWLVLIA	HACE1	361	Q8IYU2
ETEDKLWKWVSQHRL	LY75	61	O60449
KDRRLSVEIWDWDLT	PRKCB	236	P05771
EEWEREWTELLKLAS	OTUD7A	261	Q8TE49
WLSWLPLHEDKEEAV	IPO5	996	O00410
KLTEREWAEEWKHLN	CBFA2T3	386	O75081
KSALLDHIWVTRWLD	PPFIBP2	626	Q8ND30
SLTWEETEETLLLWE	IFFO1	421	Q0D2I5
LSWELDIWAQEKERL	NT5DC4	341	Q86YG4
RWAAEHRLEEKKTWL	CORO2A	451	Q92828
WQHSEWLDVVIDDRL	CAPN9	136	O14815
LAWLSLVKEELGDEW	DERA	266	Q9Y315
EELWLEWLHDEISMA	SART3	146	Q15020
SKDDWLEWLRRLSLE	MTOR	1276	P42345
EKHQLEVDEWRATWL	RUSF1	446	Q96GQ5
SWRLWDLEAQEEILH	PRPF4	346	O43172
WLDEKTWAVVLELTT	PKDREJ	1906	Q9NTG1
WSIRSEKLEWAVDEE	PSD4	731	Q8NDX1
FEHTWKELELWLEHL	URB1	671	O60287
WEDRWEWLRLILEVH	SPTBN1	2006	Q01082
RQSLDLSSEWWDDKL	BRMS1	171	Q9HCU9
VEEWATAWKVLILLE	C21orf62-AS1	36	Q17RA5
WEIWKSRSDPVLHID	PPCDC	76	Q96CD2
HIWPTLTDEEWIKVE	PRPF8	1966	Q6P2Q9
EDHTWNLEDLSVIWR	SPG11	1511	Q96JI7
DDLVKVWKWRDERLD	WDR61	41	Q9GZS3
VLDWLLSWEVLSWED	NOD2	56	Q9HC29
GANREEITKHWDWLE	TBC1D8B	81	Q0IIM8
IEDLWKRWKTSEVHN	STIM2	121	Q9P246
WLTVEVLERTWKHLS	SPTA1	2121	P02549
LHWREISSGHLELEW	MPL	396	P40238
EEETESWIKWLKEIL	TRPM8	371	Q7Z2W7
EELLRITHSEDWKLW	VEGFD	51	O43915
HIWKLQWATTILDIE	TRPV4	731	Q9HBA0
FHTHVKELWTWLEEL	TRIO	676	O75962
KLEDWAHWAKLEERS	GARIN5B	641	Q8N5Q1
LSWLHRKLEQLDWTV	GEMIN4	756	P57678
EREDNSLLKWEVGWL	KCNH8	381	Q96L42