Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	N-acylphosphatidylethanolamine-specific phospholipase D activity	PLD1 PLD2	8.83e-05	3	109	2	GO:0070290
GeneOntologyMolecularFunction	protein serine kinase activity	PLK2 RPS6KA5 CDK15 CDK11A PAK6 CASK CSNK2A1 CSNK2A3 PLK3	1.69e-04	363	109	9	GO:0106310
GeneOntologyCellularComponent	protein kinase CK2 complex	CSNK2A1 CSNK2A3	1.58e-04	4	108	2	GO:0005956
Domain	srGAP2	SRGAP2 SRGAP2C SRGAP2B	1.99e-07	3	110	3	IPR030252
Domain	FCH	SRGAP2 SRGAP2C SRGAP3 SRGAP2B	7.68e-06	22	110	4	PF00611
Domain	FCH	SRGAP2 SRGAP2C SRGAP3 SRGAP2B	7.68e-06	22	110	4	SM00055
Domain	FCH_dom	SRGAP2 SRGAP2C SRGAP3 SRGAP2B	9.25e-06	23	110	4	IPR001060
Domain	F_BAR	SRGAP2 SRGAP2C SRGAP3 SRGAP2B	1.31e-05	25	110	4	IPR031160
Domain	F_BAR	SRGAP2 SRGAP2C SRGAP3 SRGAP2B	1.31e-05	25	110	4	PS51741
Domain	PLipase_D1/D2	PLD1 PLD2	3.44e-05	2	110	2	IPR016555
Domain	PLipase_D_fam	PLD1 PLD2	3.44e-05	2	110	2	IPR015679
Domain	PROTEIN_KINASE_ATP	EPHB3 PLK2 RPS6KA5 CDK15 CDK11A PAK6 CASK CSNK2A1 EPHA2 CSNK2A3 PLK3	8.39e-05	459	110	11	PS00107
Domain	POLO_box_2	PLK2 PLK3	1.03e-04	3	110	2	IPR033695
Domain	PLDc_2	PLD1 PLD2	1.03e-04	3	110	2	PF13091
Domain	PLD-like_dom	PLD1 PLD2	1.03e-04	3	110	2	IPR025202
Domain	Prot_kinase_dom	EPHB3 PLK2 RPS6KA5 CDK15 CDK11A PAK6 CASK CSNK2A1 EPHA2 CSNK2A3 PLK3	1.46e-04	489	110	11	IPR000719
Domain	PROTEIN_KINASE_DOM	EPHB3 PLK2 RPS6KA5 CDK15 CDK11A PAK6 CASK CSNK2A1 EPHA2 CSNK2A3 PLK3	1.57e-04	493	110	11	PS50011
Domain	DUF1981	ARFGEF2 ARFGEF1	2.05e-04	4	110	2	PF09324
Domain	PLDc	PLD1 PLD2	2.05e-04	4	110	2	PF00614
Domain	-	PLK2 PLK3	2.05e-04	4	110	2	3.30.1120.30
Domain	Sec7_N	ARFGEF2 ARFGEF1	2.05e-04	4	110	2	IPR032691
Domain	Sec7_N	ARFGEF2 ARFGEF1	2.05e-04	4	110	2	PF12783
Domain	POLO_box	PLK2 PLK3	2.05e-04	4	110	2	PF00659
Domain	POLO_BOX	PLK2 PLK3	2.05e-04	4	110	2	PS50078
Domain	DCB_dom	ARFGEF2 ARFGEF1	2.05e-04	4	110	2	IPR032629
Domain	POLO_box_1	PLK2 PLK3	2.05e-04	4	110	2	IPR033701
Domain	DCB	ARFGEF2 ARFGEF1	2.05e-04	4	110	2	PF16213
Domain	Sec7_C	ARFGEF2 ARFGEF1	2.05e-04	4	110	2	IPR015403
Domain	Ser/Thr_kinase_AS	PLK2 RPS6KA5 CDK15 CDK11A PAK6 CASK CSNK2A1 CSNK2A3 PLK3	2.62e-04	357	110	9	IPR008271
Domain	S_TKc	PLK2 RPS6KA5 CDK15 CDK11A PAK6 CASK CSNK2A1 CSNK2A3 PLK3	2.73e-04	359	110	9	SM00220
Domain	PROTEIN_KINASE_ST	PLK2 RPS6KA5 CDK15 CDK11A PAK6 CASK CSNK2A1 CSNK2A3 PLK3	2.91e-04	362	110	9	PS00108
Domain	TLE_N	TLE5 TLE4	3.40e-04	5	110	2	PF03920
Domain	POLO_box_dom	PLK2 PLK3	3.40e-04	5	110	2	IPR000959
Domain	Groucho/TLE_N	TLE5 TLE4	3.40e-04	5	110	2	IPR005617
Domain	Kinase-like_dom	EPHB3 PLK2 RPS6KA5 CDK15 CDK11A PAK6 CASK CSNK2A1 EPHA2 CSNK2A3 PLK3	3.54e-04	542	110	11	IPR011009
Domain	Protein_kinase_ATP_BS	EPHB3 PLK2 RPS6KA5 CDK15 PAK6 CSNK2A1 EPHA2 CSNK2A3 PLK3	4.06e-04	379	110	9	IPR017441
Domain	Pkinase	PLK2 RPS6KA5 CDK15 CDK11A PAK6 CASK CSNK2A1 CSNK2A3 PLK3	4.22e-04	381	110	9	PF00069
Domain	PLDc	PLD1 PLD2	5.08e-04	6	110	2	SM00155
Domain	PLipase_D/transphosphatidylase	PLD1 PLD2	7.08e-04	7	110	2	IPR001736
Domain	DAGAT	AWAT1 DGAT2	7.08e-04	7	110	2	PF03982
Domain	DAGAT	AWAT1 DGAT2	7.08e-04	7	110	2	IPR007130
Domain	PLD	PLD1 PLD2	7.08e-04	7	110	2	PS50035
Domain	Cyclin_L/T	CCNT1 CCNT2	9.40e-04	8	110	2	IPR015429
Domain	Galactose-bd-like	EPHB3 CEP104 GLB1L EPHA2	2.31e-03	94	110	4	IPR008979
Domain	RECEPTOR_TYR_KIN_V_2	EPHB3 EPHA2	2.99e-03	14	110	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB3 EPHA2	2.99e-03	14	110	2	PS00790
Domain	Eph_TM	EPHB3 EPHA2	2.99e-03	14	110	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHB3 EPHA2	2.99e-03	14	110	2	IPR001426
Domain	EPH_lbd	EPHB3 EPHA2	2.99e-03	14	110	2	SM00615
Domain	Ephrin_lbd	EPHB3 EPHA2	2.99e-03	14	110	2	PF01404
Domain	EphA2_TM	EPHB3 EPHA2	2.99e-03	14	110	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB3 EPHA2	2.99e-03	14	110	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHB3 EPHA2	2.99e-03	14	110	2	IPR001090
Domain	EPH_LBD	EPHB3 EPHA2	2.99e-03	14	110	2	PS51550
Domain	-	ARFGEF2 ARFGEF1	3.43e-03	15	110	2	1.10.1000.11
Domain	Sec7	ARFGEF2 ARFGEF1	3.43e-03	15	110	2	PF01369
Domain	Sec7_alpha_orthog	ARFGEF2 ARFGEF1	3.43e-03	15	110	2	IPR023394
Domain	Sec7	ARFGEF2 ARFGEF1	3.91e-03	16	110	2	SM00222
Domain	SEC7	ARFGEF2 ARFGEF1	3.91e-03	16	110	2	PS50190
Domain	Sec7_dom	ARFGEF2 ARFGEF1	3.91e-03	16	110	2	IPR000904
Domain	SAM/pointed	EPHB3 CSNK2A1 EPHA2 ANKS3	5.07e-03	117	110	4	IPR013761
Pathway	KEGG_AXON_GUIDANCE	EPHB3 ARHGEF12 SRGAP2 PAK6 DCC SRGAP3 EPHA2	1.95e-05	129	91	7	M5539
Pubmed	Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.	SRGAP2 SRGAP2C SRGAP2B	3.16e-08	3	111	3	22559944
Pubmed	Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.	SRGAP2 SRGAP2C SRGAP2B	1.26e-07	4	111	3	22559943
Pubmed	Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.	CARM1 CUL1 SIN3A CSNK2A1 MED23	7.68e-07	53	111	5	36841324
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	CARM1 CDK11A SIN3A NKRF CCNT1 CSNK2A1 MED23	2.06e-06	182	111	7	32239614
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	CARM1 RPP40 AWAT1 CCNT1 INTS14 CTR9 MED23 SLC33A1 STAG2 ANKS3	2.20e-06	457	111	10	32968282
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	MED20 ZHX3 SIN3A CCNT1 TLE5 CTR9 CSNK2A1 TLE4	2.49e-06	268	111	8	33640491
Pubmed	All Tcf HMG box transcription factors interact with Groucho-related co-repressors.	TCF7 TLE5 TLE4	6.82e-06	12	111	3	11266540
Pubmed	Genomic analysis of murine phospholipase D1 and comparison to phospholipase D2 reveals an unusual difference in gene size.	PLD1 PLD2	1.01e-05	2	111	2	9813240
Pubmed	Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells.	PLD1 PLD2	1.01e-05	2	111	2	32814056
Pubmed	Functional analysis of mammalian phospholipase D enzymes.	PLD1 PLD2	1.01e-05	2	111	2	30369483
Pubmed	Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.	PLD1 PLD2	1.01e-05	2	111	2	16873675
Pubmed	Differential regulation of apoptosis by caspase-mediated cleavage of phospholipase D isozymes.	PLD1 PLD2	1.01e-05	2	111	2	18694819
Pubmed	Generation of choline for acetylcholine synthesis by phospholipase D isoforms.	PLD1 PLD2	1.01e-05	2	111	2	11734063
Pubmed	Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.	PLD1 PLD2	1.01e-05	2	111	2	23383154
Pubmed	Characterization of human PLD2 and the analysis of PLD isoform splice variants.	PLD1 PLD2	1.01e-05	2	111	2	9761774
Pubmed	The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.	PLD1 PLD2	1.01e-05	2	111	2	25187519
Pubmed	Phospholipase D in TCR-Mediated Signaling and T Cell Activation.	PLD1 PLD2	1.01e-05	2	111	2	29386256
Pubmed	Histone Demethylase KDM7A Contributes to the Development of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2.	DGAT2 KDM7A	1.01e-05	2	111	2	34681759
Pubmed	Phospholipase D1 is a regulator of platelet-mediated inflammation.	PLD1 PLD2	1.01e-05	2	111	2	28711718
Pubmed	Increased phospholipase D activity contributes to tumorigenesis in prostate cancer cell models.	PLD1 PLD2	1.01e-05	2	111	2	32661773
Pubmed	Phospholipase D is involved in the formation of Golgi associated clathrin coated vesicles in human parotid duct cells.	PLD1 PLD2	1.01e-05	2	111	2	24618697
Pubmed	Phospholipase D is essential for keratocyte-like migration of NBT-II cells.	PLD1 PLD2	1.01e-05	2	111	2	18344600
Pubmed	Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells.	PLD1 PLD2	1.01e-05	2	111	2	20711340
Pubmed	Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.	CSNK2A1 CSNK2A3	1.01e-05	2	111	2	14646071
Pubmed	Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.	PLD1 PLD2	1.01e-05	2	111	2	23131846
Pubmed	Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.	PLD1 PLD2	1.01e-05	2	111	2	30207376
Pubmed	Redundant functions of phospholipases D1 and D2 in platelet α-granule release.	PLD1 PLD2	1.01e-05	2	111	2	22974101
Pubmed	Phospholipase D is a target for inhibition of astroglial proliferation by ethanol.	PLD1 PLD2	1.01e-05	2	111	2	24262632
Pubmed	Assignment of casein kinase 2 alpha sequences to two different human chromosomes.	CSNK2A1 CSNK2A3	1.01e-05	2	111	2	1577469
Pubmed	The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development.	SRGAP2C SRGAP2B	1.01e-05	2	111	2	31822692
Pubmed	SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.	SRGAP2 SRGAP2C	1.01e-05	2	111	2	27373832
Pubmed	Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation.	TERF1 CSNK2A1	1.01e-05	2	111	2	18347021
Pubmed	The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells.	PLD1 PLD2	1.01e-05	2	111	2	23698760
Pubmed	Phosphatidic acid, phospholipase D and tumorigenesis.	PLD1 PLD2	1.01e-05	2	111	2	24103483
Pubmed	Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells.	PLD1 PLD2	1.01e-05	2	111	2	12615079
Pubmed	Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid.	PLD1 PLD2	1.01e-05	2	111	2	25523098
Pubmed	Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D.	PLD1 PLD2	1.01e-05	2	111	2	36362078
Pubmed	Phospholipase D messenger RNA expression and clinical role in high-grade serous carcinoma.	PLD1 PLD2	1.01e-05	2	111	2	28087476
Pubmed	Impaired brain development and reduced cognitive function in phospholipase D-deficient mice.	PLD1 PLD2	1.01e-05	2	111	2	24813107
Pubmed	Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NFkappaB signaling pathway and enhances invasion of breast cancer cells.	PLD1 PLD2	1.01e-05	2	111	2	20188462
Pubmed	Differential expression of phospholipases D1 and D2 in mouse tissues.	PLD1 PLD2	1.01e-05	2	111	2	17085061
Pubmed	Organization and alternative splicing of the murine phospholipase D2 gene.	PLD1 PLD2	1.01e-05	2	111	2	9560313
Pubmed	Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.	PLD1 PLD2	1.01e-05	2	111	2	32209478
Pubmed	In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain.	PLK2 PLK3	1.01e-05	2	111	2	24128992
Pubmed	Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.	ARFGEF2 ARFGEF1	1.01e-05	2	111	2	23918382
Pubmed	Cross-talk between phospholipase D and MAP kinases activities.	PLD1 PLD2	1.01e-05	2	111	2	19896495
Pubmed	β-1,3-Glucan-induced host phospholipase D activation is involved in Aspergillus fumigatus internalization into type II human pneumocyte A549 cells.	PLD1 PLD2	1.01e-05	2	111	2	21760893
Pubmed	Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report.	PLD1 PLD2	1.01e-05	2	111	2	23868933
Pubmed	Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.	EPHB3 TCF7	1.01e-05	2	111	2	12408869
Pubmed	Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2.	PLD1 PLD2	1.01e-05	2	111	2	12782287
Pubmed	Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury.	PLD1 PLD2	1.01e-05	2	111	2	29437245
Pubmed	Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2.	PLD1 PLD2	1.01e-05	2	111	2	9582313
Pubmed	Investigation on PLK2 and PLK3 substrate recognition.	PLK2 PLK3	1.01e-05	2	111	2	22828320
Pubmed	Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.	CSNK2A1 CSNK2A3	1.01e-05	2	111	2	12860116
Pubmed	Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.	ARFGEF2 ARFGEF1	1.01e-05	2	111	2	17360629
Pubmed	Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.	ARFGEF2 ARFGEF1	1.01e-05	2	111	2	10716990
Pubmed	PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.	PLD1 PLD2	1.01e-05	2	111	2	34610470
Pubmed	Structure and regulation of human phospholipase D.	PLD1 PLD2	1.01e-05	2	111	2	33495125
Pubmed	PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury.	PLD1 PLD2	1.01e-05	2	111	2	33368247
Pubmed	Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight.	PLD1 PLD2	1.01e-05	2	111	2	27299737
Pubmed	The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium.	PLD1 PLD2	1.01e-05	2	111	2	25172550
Pubmed	The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.	SRGAP2 SRGAP3	1.01e-05	2	111	2	23505444
Pubmed	Expression of MARCKS effector domain mutants alters phospholipase D activity and cytoskeletal morphology of SK-N-MC neuroblastoma cells.	PLD1 PLD2	1.01e-05	2	111	2	16341931
Pubmed	Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.	ARFGEF2 ARFGEF1	1.01e-05	2	111	2	18203920
Pubmed	Phospholipase D in cell proliferation and cancer.	PLD1 PLD2	1.01e-05	2	111	2	14517341
Pubmed	Importance of PLD2 in an IL-23 driven psoriasiform dermatitis model and potential link to human psoriasis.	PLD1 PLD2	1.01e-05	2	111	2	37455419
Pubmed	Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.	PLD1 PLD2	1.01e-05	2	111	2	32971863
Pubmed	Role of phospholipases D1 and 2 in astroglial proliferation: effects of specific inhibitors and genetic deletion.	PLD1 PLD2	1.01e-05	2	111	2	25967349
Pubmed	Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29.	PLD1 PLD2	1.01e-05	2	111	2	19707939
Pubmed	Increased expression of two phospholipase D isoforms during experimentally induced hippocampal mossy fiber outgrowth.	PLD1 PLD2	1.01e-05	2	111	2	14999815
Pubmed	Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing.	PLD1 PLD2	1.01e-05	2	111	2	30555342
Pubmed	Molecular cloning of the human casein kinase II alpha subunit.	CSNK2A1 CSNK2A3	1.01e-05	2	111	2	2752008
Pubmed	Role of phospholipase D in bleomycin-induced mitochondrial reactive oxygen species generation, mitochondrial DNA damage, and pulmonary fibrosis.	PLD1 PLD2	1.01e-05	2	111	2	31090437
Pubmed	Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.	CSNK2A1 CSNK2A3	1.01e-05	2	111	2	8420794
Pubmed	Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	1.01e-05	2	111	2	10212200
Pubmed	Expression of phospholipase D isozymes in mouse lungs during postnatal development.	PLD1 PLD2	1.01e-05	2	111	2	19652486
Pubmed	Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization.	PLD1 PLD2	1.01e-05	2	111	2	9395408
Pubmed	Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation.	PLD1 PLD2	1.01e-05	2	111	2	18432522
Pubmed	Phospholipase D and cancer metastasis: A focus on exosomes.	PLD1 PLD2	1.01e-05	2	111	2	36272918
Pubmed	Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.	ARFGEF2 ARFGEF1	1.01e-05	2	111	2	18417613
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	ZHX3 AMPD3 CAPN3 ARHGEF12 CDK11A PP2D1 TERF1 DCP1B TBC1D12 PAM PLD1	1.29e-05	686	111	11	29987050
Pubmed	Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.	OR1A2 OR1D4 OR1D5	1.72e-05	16	111	3	10673334
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CARM1 MED20 CUL1 ZHX3 SIN3A NKRF THOC5 CCNT1 CCNT2 CTR9 CSNK2A1 MED23 STAG2	2.19e-05	1014	111	13	32416067
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MED20 USP30 MAN2A1 RPP40 ARHGEF12 CDK11A SRGAP2 NKRF CASK CCNT1 CTR9 CSNK2A1 SIPA1L1 MIOS MED23 STAG2	2.21e-05	1497	111	16	31527615
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CARM1 CUL1 USP18 PLK2 RPS6KA5 CAPN3 CDK11A PLXND1 MDM4 CSNK2A1 PLK3	2.28e-05	730	111	11	34857952
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	CUL1 RAPSN RPS6KA5 CDK15 CDK11A PAK6 MDM4 EPHA2	2.69e-05	372	111	8	22939624
Pubmed	Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.	EPHB3 PLXND1 DCC TLE4	2.96e-05	55	111	4	32561725
Pubmed	Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells.	PLD1 PLD2	3.02e-05	3	111	2	17640750
Pubmed	Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation.	RPS6KA5 CSNK2A1	3.02e-05	3	111	2	19933278
Pubmed	Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.	CSNK2A1 CSNK2A3	3.02e-05	3	111	2	15684395
Pubmed	Regulation of P-TEFb elongation complex activity by CDK9 acetylation.	CCNT1 CCNT2	3.02e-05	3	111	2	17452463
Pubmed	Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.	ARFGEF2 ARFGEF1	3.02e-05	3	111	2	19332778
Pubmed	Involvement of phospholipase D in regulating expression of anti-microbial peptide human beta-defensin-2.	PLD1 PLD2	3.02e-05	3	111	2	17986621
Pubmed	Specific functions of BIG1 and BIG2 in endomembrane organization.	ARFGEF2 ARFGEF1	3.02e-05	3	111	2	20360857
Pubmed	Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.	PLK2 PLK3	3.02e-05	3	111	2	11039900
Pubmed	Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.	CSNK2A1 CSNK2A3	3.02e-05	3	111	2	2174700
Pubmed	Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function.	PLD1 PLD2	3.02e-05	3	111	2	26392467
Pubmed	Cyclin T2 is essential for mouse embryogenesis.	CCNT1 CCNT2	3.02e-05	3	111	2	19364821
Pubmed	AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	3.02e-05	3	111	2	16866877
Pubmed	Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation.	CCNT1 CCNT2	3.02e-05	3	111	2	10329126
Interaction	HEXIM2 interactions	CDK11A TERF1 CCNT1 CCNT2 TLE5 CSNK2A1	4.16e-06	82	104	6	int:HEXIM2
Interaction	MDFIC interactions	RPS6KA5 CCNT1 CSNK2A1	1.56e-05	10	104	3	int:MDFIC
Interaction	PKD2L2 interactions	ITPR3 PKD2L2 SERPINB3	2.14e-05	11	104	3	int:PKD2L2
Interaction	ELL2 interactions	CASK CCNT1 CCNT2 CTR9	2.44e-05	33	104	4	int:ELL2
Interaction	FITM2 interactions	CARM1 GPR21 RPP40 AWAT1 CCNT1 INTS14 CTR9 SLC33A1 ANKS3	3.28e-05	310	104	9	int:FITM2
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP2 SRGAP2C SRGAP3 SRGAP2B	2.95e-06	23	80	4	1288
GeneFamily	Cyclins\|P-TEFb complex	CCNT1 CCNT2	1.15e-04	4	80	2	1281
GeneFamily	Diacylglycerol O-acyltransferase 2 family	AWAT1 DGAT2	5.32e-04	8	80	2	1235
GeneFamily	Olfactory receptors, family 1	OR1A2 OR1D4 OR1D5	7.32e-04	40	80	3	147
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB3 EPHA2	1.70e-03	14	80	2	1095
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRR3 GABRA6	3.15e-03	19	80	2	563
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	NKRF GPATCH11	4.22e-03	22	80	2	579
GeneFamily	Cyclin dependent kinases	CDK15 CDK11A	5.87e-03	26	80	2	496
GeneFamily	Cyclins	CCNT1 CCNT2	6.78e-03	28	80	2	473
GeneFamily	Sterile alpha motif domain containing	EPHB3 EPHA2 ANKS3	6.99e-03	88	80	3	760
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#1	EPHB3 CENPT SRGAP3 TLE4 PAM KDM7A PLD1 GPRASP2	3.70e-05	255	104	8	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000_K1
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_500_k-means-cluster#4	EPHB3 SRGAP3 TLE4 KDM7A PLD1 GPRASP2	4.17e-05	129	104	6	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_500_K4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF12 SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B DNAH9	3.67e-07	183	110	7	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF12 SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B DNAH9	3.67e-07	183	110	7	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	COVID-19-kidney-Podocyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SRGAP2 SRGAP2C ZDHHC6 P3H2 TMEM150C SRGAP2B	4.87e-06	175	110	6	a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCell	3'_v3-blood-Mast-Mast_cell_granulo-myelo\|blood / Manually curated celltypes from each tissue	CDK15 FREM1 KMO BEND6 SRGAP3 PLD1	5.03e-06	176	110	6	d421b6b8e13894dbcf29548c0a6516c3dee8f9b1
ToppCell	facs-Thymus-Flowthrough-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 CAPN3 PLXND1 SESN1 CSNK2A1 EDEM1	7.34e-06	188	110	6	59b71462338a7efbacf46577cb07e9db3363afee
ToppCell	Mild/Remission-B_naive-4\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ZHX3 HVCN1 KMO TLE5 SIPA1L1	3.34e-05	148	110	5	dd5e1bc02824e743e1c030a303e32f27a359a8ca
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PLK2 TCF7 GLB1L TSPYL2 DGAT2	4.03e-05	154	110	5	874b1220337276489a89fcc9a39bc81ba6b68baf
ToppCell	Mild/Remission-B_naive-4\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ZHX3 HVCN1 KMO TLE5 SIPA1L1	6.27e-05	169	110	5	c3a6179a64589a370108fea809b157839347759c
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	USP18 SCRN3 TCF7 SRGAP2C DNAH9	6.45e-05	170	110	5	fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCell	droplet-Tongue-nan-24m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP18 PLK2 DGAT2 EPHA2 PLK3	6.82e-05	172	110	5	6ece9bb9f31685c918ca4cb7b82cf6ad1cad48af
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMO ADORA3 SRGAP3 P3H2 TTC39A	6.82e-05	172	110	5	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	3'_v3-blood-Mast\|blood / Manually curated celltypes from each tissue	CDK15 FREM1 KMO SRGAP3 BAIAP2L2	6.82e-05	172	110	5	e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC38A5 CPB1 PLXND1 SESN1 EDEM1	7.01e-05	173	110	5	c62e3ffed55bbb00dcaef6da0aab8446f3f55085
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC38A5 CPB1 PLXND1 SESN1 EDEM1	7.01e-05	173	110	5	f612d4ea9ab8dcde475f4118bca3e49be786e7fa
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	TCF7 TTLL5 TSPYL2 CCNT2 EDEM1	7.20e-05	174	110	5	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP18 KMO ADORA3 SRGAP3 TMEM150C	7.40e-05	175	110	5	bb058e714d21a0ec8532eaf3c7dd2faf78016bc0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	7.81e-05	177	110	5	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	8.02e-05	178	110	5	edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCF7 TSPYL2 SESN1 CASK TLE5	8.45e-05	180	110	5	05f14cd367021891166825a8aac171227e2bcd97
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	8.45e-05	180	110	5	d685fa2b013bc085dbef7c40956ed3043f83e483
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLK2 GPR21 PLXND1 ITPR3 ATP13A3	9.13e-05	183	110	5	3427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	9.13e-05	183	110	5	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	9.13e-05	183	110	5	612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	9.13e-05	183	110	5	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	(4)_B_cells-(4)_B_mantle\|(4)_B_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	ZHX3 MDM4 HVCN1 SESN1 TLE4	9.13e-05	183	110	5	21b7fb6482eb1d5d31a4029e47e0992e8ddc8e2c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	9.13e-05	183	110	5	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	URO-Myeloid-pDC\|URO / Disease, Lineage and Cell Type	TSPYL2 BEND6 P3H2 EPHA2 GPATCH11	9.37e-05	184	110	5	0edb5dd003c2bca0b9e3ec18d03610d68bd52538
ToppCell	P28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLK2 CENPT GPR21 PLXND1 ATP13A3	9.37e-05	184	110	5	8ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	9.37e-05	184	110	5	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	facs-Thymus\|facs / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 CAPN3 CPB1 TLE5 EDEM1	9.37e-05	184	110	5	58beef66bbbde2479ec69dfef392d5941cedf230
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN2A1 RPS6KA5 ITPR3 CCNT1 MED23	9.61e-05	185	110	5	87151ab95530e70d61328b336518df58db584acb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	9.61e-05	185	110	5	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	9.61e-05	185	110	5	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	facs-Thymus-Flowthrough-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 CAPN3 PLXND1 SESN1 EDEM1	9.61e-05	185	110	5	dc59b8dc459a3c444c9634a0d438cbef54c40036
ToppCell	ICU-NoSEP-Myeloid-pDC\|ICU-NoSEP / Disease, Lineage and Cell Type	BEND6 P3H2 EPHA2 GPATCH11 TTC39A	9.61e-05	185	110	5	7564a47df4a4e3af30d40aa0f48bd9d9c82358ae
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP18 BEND6 P3H2 EPHA2 TTC39A	9.86e-05	186	110	5	31df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP18 BEND6 P3H2 EPHA2 TTC39A	9.86e-05	186	110	5	eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	USP18 BEND6 P3H2 EPHA2 TTC39A	9.86e-05	186	110	5	b95be984e308d4f9061274a35995ec558d434e74
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	USP18 BEND6 P3H2 EPHA2 TTC39A	9.86e-05	186	110	5	8f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	USP18 BEND6 P3H2 EPHA2 TTC39A	9.86e-05	186	110	5	95c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP18 BEND6 P3H2 EPHA2 TTC39A	9.86e-05	186	110	5	b70cd94c651b56dcf2e55554533a5f1130845390
ToppCell	COVID-19_Severe-Myeloid-pDC\|COVID-19_Severe / Disease group, lineage and cell class	USP18 BEND6 P3H2 EPHA2 TTC39A	9.86e-05	186	110	5	3db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	1.01e-04	187	110	5	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	1.04e-04	188	110	5	9db778c1d9e622a68337212296e3a1ed8f771fa5
ToppCell	COVID-19_Mild-pDC\|COVID-19_Mild / Disease condition and Cell class	TSPYL2 BEND6 P3H2 EPHA2 TTC39A	1.04e-04	188	110	5	62d33d2990d4a2d32bd0863147e47f656df1966e
ToppCell	COVID-19_Severe-pDC\|World / disease group, cell group and cell class	USP18 BEND6 P3H2 EPHA2 TTC39A	1.04e-04	188	110	5	4c8e328b8206120708b05ea3c5865a0200dc5c4e
ToppCell	COVID-19_Mild-pDC-\|COVID-19_Mild / Disease condition and Cell class	TSPYL2 BEND6 P3H2 EPHA2 TTC39A	1.04e-04	188	110	5	a75c2cf2f8dae343c13aaa66b637658b935ed10a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	1.04e-04	188	110	5	047c4e0b03fc8334e38c48977e41d26dbe229d47
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLK2 GPR21 PLXND1 ITPR3 ATP13A3	1.06e-04	189	110	5	9da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCell	COPD-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	SRGAP2 SRGAP2C TLE4 SIPA1L1 SRGAP2B	1.09e-04	190	110	5	aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLK2 GPR21 PLXND1 ITPR3 ATP13A3	1.09e-04	190	110	5	d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLK2 GPR21 PLXND1 ITPR3 ATP13A3	1.12e-04	191	110	5	3307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLK2 GPR21 PLXND1 ITPR3 ATP13A3	1.14e-04	192	110	5	285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-immature_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 CAPN3 SESN1 TLE5 EDEM1	1.14e-04	192	110	5	cd9bccbef1ef6bb39c310039884e2acb81e63c7c
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP2 SRGAP2C ZDHHC6 TMEM150C SRGAP2B	1.17e-04	193	110	5	3eaa0461618582a1754400624350d269d24e750a
ToppCell	Club_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	PLK2 INHBB SRGAP3 SERPINB3 TMEM150C	1.17e-04	193	110	5	6582c0367052b9d10fb629c383ee0c55872afd2d
ToppCell	VE-pDC-\|VE / Condition, Cell_class and T cell subcluster	KMO BEND6 P3H2 EPHA2 TTC39A	1.17e-04	193	110	5	583724de588fcde3aeda056138c522dc0225a387
ToppCell	VE-pDC\|VE / Condition, Cell_class and T cell subcluster	KMO BEND6 P3H2 EPHA2 TTC39A	1.17e-04	193	110	5	bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PLK2 CDK15 DCC FREM1 SRGAP3	1.20e-04	194	110	5	5f5f0cdeacd5e1b28717d78dabdb9eb95f661e36
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|lymph-node_spleen / Manually curated celltypes from each tissue	PLK2 TCF7 TSPYL2 NKRF PLK3	1.26e-04	196	110	5	c945dc6c56c61732e065daaad7e6f48c02ee183c
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	AMPD3 SESN1 ADORA3 SRGAP3 P3H2	1.26e-04	196	110	5	e8c4eeb4b6c6d9bccca2adb942d4cfbaab39636c
ToppCell	10x3'2.3-week_17-19\|World / cell types per 3 fetal stages;per 3',per 5'	PLK2 MDM4 TLE5 TLE4 PLK3	1.29e-04	197	110	5	f5cfad0b42d0f817e22cc78b9bfb2b4b7e4330ed
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SRGAP2 ADORA3 SRGAP2C SRGAP2B PLK3	1.32e-04	198	110	5	979c391a3b7130e4f91d76a9eb8079fb0f445c4c
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SRGAP2 PLXND1 TBC1D12 ATP13A3 PLK3	1.32e-04	198	110	5	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TSPYL2 ARFGEF1 CDK11A MDM4 CCNT1	1.35e-04	199	110	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	CEP104 INHBB VPS13D EPHA2 STAG2	1.35e-04	199	110	5	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	mild-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CUL1 PLK2 SRGAP2 BEND6 SRGAP3	1.38e-04	200	110	5	86f585bf9066b179bbcbc703bf43f15da4a07284
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SESN1 MIOS TTC39A PLD2 PLK3	1.38e-04	200	110	5	88d713dfc792e7609bf7ecfb28f87cb748088570
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2 CASK SRGAP2C TBC1D12 SRGAP2B	1.38e-04	200	110	5	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2 CASK SRGAP2C TBC1D12 SRGAP2B	1.38e-04	200	110	5	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2 CASK SRGAP2C TBC1D12 SRGAP2B	1.38e-04	200	110	5	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2 CASK SRGAP2C TBC1D12 SRGAP2B	1.38e-04	200	110	5	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2 CASK SRGAP2C TBC1D12 SRGAP2B	1.38e-04	200	110	5	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SRGAP2 CASK SRGAP2C TBC1D12 SRGAP2B	1.38e-04	200	110	5	33036d21c1c82109284473a515c4f890b33fdd5c
Disease	Corpus Callosum Malformation	SIN3A DCC	1.25e-05	2	105	2	C3179058
Disease	developmental cardiac valvular defect (implicated_via_orthology)	PLD1 PLD2	1.25e-05	2	105	2	DOID:0080633 (implicated_via_orthology)
Disease	Agenesis of corpus callosum	SIN3A DCC	3.75e-05	3	105	2	C0175754
Disease	Microcephaly	KIFBP SIN3A CASK STAG2	9.77e-05	67	105	4	C0025958
Disease	Severe Congenital Microcephaly	KIFBP SIN3A CASK	1.83e-04	31	105	3	C3853041
Disease	cholesteryl ester 22:6 measurement	RAPSN SRGAP2 SRGAP3	2.01e-04	32	105	3	EFO_0010350
Disease	cysteine-rich with EGF-like domain protein 1 measurement	JAGN1 SRGAP2 SRGAP3	2.01e-04	32	105	3	EFO_0021870
Disease	Microlissencephaly	KIFBP SIN3A CASK	2.21e-04	33	105	3	C1956147
Disease	quinolinate measurement	KMO CCNT2	2.60e-04	7	105	2	EFO_0800175
Disease	syndromic X-linked intellectual disability (implicated_via_orthology)	CASK KDM7A	3.46e-04	8	105	2	DOID:0060309 (implicated_via_orthology)
Disease	Situs Inversus	DNAH9 ANKS3	6.76e-04	11	105	2	C0037221
Disease	developmental disorder of mental health (implicated_via_orthology)	SIN3A PLXND1 GABRR3	7.16e-04	49	105	3	DOID:0060037 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	TCF7 CAPN3 PLXND1 ITPR3 GABRA6	1.05e-03	215	105	5	DOID:9970 (implicated_via_orthology)
Disease	Neoplasm of uncertain or unknown behavior of bladder	MDM4 STAG2	1.28e-03	15	105	2	C0496930
Disease	Benign neoplasm of bladder	MDM4 STAG2	1.28e-03	15	105	2	C0154017
Disease	Carcinoma in situ of bladder	MDM4 STAG2	1.28e-03	15	105	2	C0154091
Disease	waist-hip ratio	ZHX3 AMPD3 RAPSN ARFGEF1 SRGAP2 PLXND1 DCP1B SRGAP3 CSNK2A1 PAM TTC39A PLD1	1.39e-03	1226	105	12	EFO_0004343
Disease	Profound Mental Retardation	KIFBP SIN3A DCC SRGAP3	1.56e-03	139	105	4	C0020796
Disease	Mental Retardation, Psychosocial	KIFBP SIN3A DCC SRGAP3	1.56e-03	139	105	4	C0025363
Disease	Mental deficiency	KIFBP SIN3A DCC SRGAP3	1.56e-03	139	105	4	C0917816
Disease	blood lead measurement	CPB1 SRGAP2 SRGAP3	1.70e-03	66	105	3	EFO_0007040
Disease	sweet liking measurement	RGS9 DCC	1.85e-03	18	105	2	EFO_0010156
Disease	Carcinoma of bladder	MDM4 STAG2	1.85e-03	18	105	2	C0699885
Disease	Alzheimer disease, educational attainment	PLK2 ARFGEF2 DCC MDM4 INTS14	1.93e-03	247	105	5	EFO_0011015, MONDO_0004975
Disease	level of Phosphatidylcholine (18:1_20:4) in blood serum	RAPSN DCC	2.52e-03	21	105	2	OBA_2045104
Disease	hemoglobin A1 measurement	ZHX3 RAPSN SRGAP2 PLXND1 INTS14 SRGAP3 PLD1	2.61e-03	520	105	7	EFO_0007629
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	PLK2 RAPSN CAPN3 DGAT2 SIPA1L1	3.02e-03	274	105	5	EFO_0004530, EFO_0004612

Protein segments in the cluster

Peptide	Gene	Start	Entry
VDHSMMLKYFATFEV	TBC1D12	626	O60347
HQVTVYSMYVSIMAF	SLC33A1	421	O00400
YSMYVSIMAFNAKVS	SLC33A1	426	O00400
QSISLMNAEVYYMHE	ERVPABLB-1	361	P60509
LTINTAIVYMHRFYM	CCNT2	56	O60583
FIYRMYTIDMHSQLE	CATSPERD	396	Q86XM0
SHANSMMNPIVYAYK	ADORA3	271	P0DMS8
YSIRKQYVMLHDMVA	ATP13A3	251	Q9H7F0
TVMFEIMKTYGHTYE	ARFGEF1	1406	Q9Y6D6
GMYKYMSSQHLFKLL	ARFGEF2	1601	Q9Y6D5
NLYIMYYMEAKHAVS	PAM	311	P19021
YYMEAKHAVSFMTCT	PAM	316	P19021
TAIVYMHRFYMIQSF	CCNT1	61	O60563
LMQVLYTNEYMATHS	BEND6	196	Q5SZJ8
SSTMQYVILMYMKHL	ARHGEF12	541	Q9NZN5
MQFHYTKEALMEEYA	AMPD3	666	Q01432
SLKYRAMSQYHMAVA	RAPSN	201	Q13702
VVHMMIEYSNFEKEY	QRFPR	291	Q96P65
YVLDAAQTHIYMLMK	RGS9	386	O75916
AQTHIYMLMKKDSYA	RGS9	391	O75916
MDMEFLYHVGYILTS	ITPR3	2316	Q14573
KNYYFVSHDQMMQDI	CASK	786	O14936
THQIMDLNLDTMYYF	DCC	1006	P43146
MYFMIALAKADSYTL	OR1A2	101	Q9Y585
MRDYQHFNVVEMYKS	PAK6	456	Q9NQU5
ADSKMTLHNYVKYFM	KDM7A	201	Q6ZMT4
VYPMTTMAYIQDAKH	MAN2A1	916	Q16706
ERVAMHYQMSVTLKY	JAGN1	21	Q8N5M9
MFTVKEVMHYLGQYI	MDM4	46	O15151
KNNYAAMVFHYMSIT	HVCN1	131	Q96D96
KLSTMSMLYFDDEYN	INHBB	376	P09529
VYSHVDYSNEAMQKM	GLYAT	261	Q6IB77
DQFYRSTMAIYKSIM	BAIAP2L2	6	Q6UXY1
YMLFNERMLESYLHA	CARM1	261	Q86X55
GYLYLMTSHQMARVK	PLXND1	531	Q9Y4D7
SYHTPEKDMMVSVFY	OR2T4	296	Q8NH00
MRAMQHAEVYYKLIS	PBDC1	41	Q9BVG4
FTQHAVNYMKVAYMP	FREM1	721	Q5H8C1
DFLYHMKYMFTGDSV	MED23	1296	Q9ULK4
MIMYKTNSSHYGEFL	PIERCE2	56	H3BRN8
MKYLSEMNYVHRDLA	EPHB3	746	P54753
TVYFHLQRKMGYFMI	GABRA6	231	Q16445
SAMMKDSPFYQHYDL	RPS6KA5	411	O75582
FMLNSTLYFSYTHMV	P3H2	546	Q8IVL5
YEAYLFSMTQAAMKK	DCP1B	601	Q8IZD4
LLAHQYMISSKIEFY	CEP104	61	O60308
YMYEILKALDYCHSM	CSNK2A3	136	Q8NEV1
NMDFTMTFYLRHYWK	GABRR3	101	A8MPY1
AVRYYSHMKLNMAEE	GPATCH11	16	Q8N954
ISDLSMYNYIEMRAH	KMO	356	O15229
FVFEYMHTDLAQYMS	CDK15	176	Q96Q40
SMAKSRYMELYTHVY	CUL1	36	Q13616
IKMQQYTEHFMAAGY	EPHA2	916	P29317
TMLFEHMATNYKLEF	INTS14	36	Q96SY0
SHYVKLFSFYAKMPM	CENPT	461	Q96BT3
AVKQDHGFMLYRTYM	GLB1L	406	Q6UWU2
SQEMVDKYHALYMDA	AWAT1	291	Q58HT5
LYTMADKIIMYDQNH	CTR9	116	Q6PD62
YIVMNYVEHDLKSLM	CDK11A	501	Q9UQ88
YMYEILKALDYCHSM	CSNK2A1	136	P68400
MTIKDYDNELLYMAH	EDEM1	251	Q92611
QYGHMKIVALMDTYS	ANKS3	211	Q6ZW76
LLEGLSYLESFYHMM	ERAP2	696	Q6P179
YFIMNDLSKIHPMYQ	DNAH9	3686	Q9NYC9
HTDSYFTLFIVMMLY	GPR21	186	Q99679
QLYDIITMRYADKHM	CAPN3	761	P20807
SELYSFALFKAMSHM	HCN2	411	Q9UL51
SIKAYLTIHSYSQMM	CPB1	296	P15086
EIAHAYYDMMDLKVA	KIFBP	476	Q96EK5
DLYHTMYMEALVKLF	DGAT2	356	Q96PD7
KLMYVMHNSEYPLSC	MED20	61	Q9H944
AMVYLQPLHTYSMKD	OR1D4	256	P47884
AMVYLQPLHTYSMKD	OR1D5	256	P58170
STMMSYFSKYQIQEH	RPP40	191	O75818
IAYNLTYNTMAMHKD	SESN1	381	Q9Y6P5
SASFNKMSIEYKYEM	NKRF	356	O15226
LKMPMYRNYHATTEF	PLD1	191	Q13393
FYSSVKAEMLHMYSQ	SLC38A5	316	Q8WUX1
FAAAYSYLDTAKMMT	SCRN3	221	Q0VDG4
LTMTIDYHTLIANYM	GPRASP2	706	Q96D09
TYKDYEIMFHVSTML	SIPA1L1	676	O43166
MFTIHAYIAFTMDKL	SIN3A	986	Q96ST3
VLNELYSVMKTYHMY	SRGAP2C	156	P0DJJ0
YSVMKTYHMYNADSI	SRGAP2C	161	P0DJJ0
VLNELYSVMKTYHMY	SRGAP2B	156	P0DMP2
YSVMKTYHMYNADSI	SRGAP2B	161	P0DMP2
YFILMAQSIHMYAAR	TMEM150C	181	B9EJG8
HMSSYIASLTYIIKM	SLCO1B7	301	G3V0H7
DSQLHKPMYYFLSML	OR5T2	91	Q8NGG2
TYKSIQMMRQYTSFH	SERPINB3	206	P29508
ASEKSEMQRHYVMYY	TLE5	51	Q08117
IFVMTMYTQLYHRLS	ZDHHC6	161	Q9H6R6
ILRYFASYMEQHLMK	PLK3	531	Q9H4B4
HISMGYKMKLYFQTN	TSPYL2	301	Q9H2G4
LWYTLHFMKQYTEDM	MIOS	426	Q9NXC5
VTNELYTVMKTYHMY	SRGAP3	156	O43295
LASEKTEMQRHYVMY	TLE4	56	Q04727
MKMYSDAFLNDSYLK	STAG2	316	Q8N3U4
VLNELYSVMKTYHMY	SRGAP2	156	O75044
YSVMKTYHMYNADSI	SRGAP2	161	O75044
FSYNHMMEKIKSYVN	TERF1	231	P54274
NPHMYYLNKVMSSLF	PKD2L2	51	Q9NZM6
MYKETVYSAFNLLMH	TCF7	116	P36402
MIIYDKMSIFNQHTY	ZNF420	111	Q8TAQ5
NEFLMMDIYKYHLLG	USP30	346	Q70CQ3
DIFSYLLHLMYTGKM	ZBTB2	71	Q8N680
YHWQETAYLLVYMKM	USP18	356	Q9UMW8
VLKYFSHYMEENLMD	PLK2	571	Q9NYY3
HLTFYYLMNLNIMTV	THOC5	361	Q13769
QDYYMTHKMLYEEDL	ZHX3	851	Q9H4I2
MSFYRNYHAMTEFLE	PLD2	176	O14939
YHSLTYATILEMQAM	TTC39A	56	Q5SRH9
IAHKEMEMQYFYPAT	WDR87	2656	Q6ZQQ6
GSYLEHKTSMNYMLA	TTLL5	496	Q6EMB2
MTTFHMYKETYCPII	PP2D1	471	A8MPX8
AHLMSTKMYERYSLS	VPS13D	806	Q5THJ4
LAYLMKYHAMSLLDA	DUSP18	116	Q8NEJ0