Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear membrane	RANBP2 DHX37 MATR3 DNAJC2 NOS1AP	1.50e-04	349	31	5	GO:0031965
MousePheno	embryonic lethality before implantation	RANBP2 ZNF830 SUPT6H DHX37 MATR3 RNF20	3.40e-06	242	25	6	MP:0006204
MousePheno	embryonic lethality before implantation, complete penetrance	RANBP2 ZNF830 SUPT6H DHX37 RNF20	2.58e-05	203	25	5	MP:0011094
MousePheno	embryonic lethality prior to organogenesis, complete penetrance	PSMD4 RANBP2 ZNF830 SUPT6H DHX37 MATR3 DNAJC2 RNF20	3.89e-05	772	25	8	MP:0014259
MousePheno	embryonic lethality prior to tooth bud stage, complete penetrance	PSMD4 RANBP2 ZNF830 SUPT6H DHX37 MATR3 DNAJC2 RNF20	4.15e-05	779	25	8	MP:0014257
MousePheno	embryonic lethality prior to tooth bud stage	PSMD4 RANBP2 ZNF830 SUPT6H DHX37 GFPT1 MATR3 DNAJC2 NUFIP1 RNF20	7.06e-05	1383	25	10	MP:0013293
MousePheno	embryonic lethality prior to organogenesis	PSMD4 RANBP2 ZNF830 SUPT6H DHX37 MATR3 DNAJC2 NUFIP1 RNF20	1.45e-04	1204	25	9	MP:0013292
Domain	S1	SUPT6H TTC14	1.19e-04	10	31	2	PS50126
Domain	S1	SUPT6H TTC14	1.74e-04	12	31	2	SM00316
Domain	S1_domain	SUPT6H TTC14	1.74e-04	12	31	2	IPR003029
Domain	S1_dom	SUPT6H TTC14	1.74e-04	12	31	2	IPR022967
Domain	TPR_1	RANBP2 PPID TTC14	4.41e-04	90	31	3	PF00515
Domain	TPR_1	RANBP2 PPID TTC14	4.41e-04	90	31	3	IPR001440
Domain	Cyclophilin-type_PPIase_CS	RANBP2 PPID	4.48e-04	19	31	2	IPR020892
Domain	Pro_isomerase	RANBP2 PPID	6.03e-04	22	31	2	PF00160
Domain	-	RANBP2 PPID	6.03e-04	22	31	2	2.40.100.10
Domain	Cyclophilin-type_PPIase_dom	RANBP2 PPID	6.03e-04	22	31	2	IPR002130
Domain	Cyclophilin-like_dom	RANBP2 PPID	6.03e-04	22	31	2	IPR029000
Domain	CSA_PPIASE_1	RANBP2 PPID	6.03e-04	22	31	2	PS00170
Domain	CSA_PPIASE_2	RANBP2 PPID	6.03e-04	22	31	2	PS50072
Domain	ZnF_U1	ZNF830 MATR3	1.05e-03	29	31	2	SM00451
Domain	Znf_U1	ZNF830 MATR3	1.05e-03	29	31	2	IPR003604
Domain	TPR	RANBP2 PPID TTC14	1.26e-03	129	31	3	SM00028
Domain	TPR_repeat	RANBP2 PPID TTC14	1.37e-03	133	31	3	IPR019734
Domain	TPR-contain_dom	RANBP2 PPID TTC14	1.94e-03	150	31	3	IPR013026
Domain	TPR	RANBP2 PPID TTC14	2.54e-03	165	31	3	PS50005
Domain	TPR_REGION	RANBP2 PPID TTC14	2.54e-03	165	31	3	PS50293
Domain	-	RANBP2 PPID TTC14	4.80e-03	207	31	3	1.25.40.10
Domain	Prefoldin	KIF20B RNF20	6.34e-03	72	31	2	IPR009053
Domain	TPR-like_helical_dom	RANBP2 PPID TTC14	6.66e-03	233	31	3	IPR011990
Domain	NA-bd_OB-fold	SUPT6H TTC14	8.35e-03	83	31	2	IPR012340
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	RRP15 PSMD4 RANBP2 CAPRIN1 SUPT6H DHX37 KIF20B MATR3 RNF20 TTC14	8.52e-09	989	31	10	36424410
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RRP15 PSMD4 RANBP2 EIF2A CAPRIN1 DHX37 KIF20B GFPT1 GOLGA4 MATR3 RNF20	1.23e-08	1353	31	11	29467282
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RRP15 PSMD4 RANBP2 CAPRIN1 SUPT6H DHX37 GFPT1 GOLGA4 MATR3 RNF20	2.61e-07	1425	31	10	30948266
Pubmed	Apigenin inhibits C5a-induced proliferation of human nasopharyngeal carcinoma cells through down-regulation of C5aR.	KAT2B C5	2.31e-06	3	31	2	29685955
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	RANBP2 EIF2A CAPRIN1 SUPT6H GFPT1 GOLGA4 MATR3 DNAJC2 RNF20	2.67e-06	1415	31	9	28515276
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	RANBP2 KDM5A CAPRIN1 SUPT6H MATR3	4.06e-06	272	31	5	31010829
Pubmed	SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.	SUPT6H RNF20	4.61e-06	4	31	2	24441044
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ANKRD35 RRP15 PSMD4 RANBP2 PPID CAPRIN1 GFPT1 MATR3	1.01e-05	1247	31	8	27684187
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	RRP15 EIF2A CAPRIN1 DHX37 KIF20B GFPT1 MATR3 DNAJC2	1.07e-05	1257	31	8	36526897
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	MANF PSMD4 KDM5A CAPRIN1 GFPT1 SLC26A6 MATR3 RNF20	1.58e-05	1327	31	8	32694731
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	RANBP2 GFPT1 MATR3 RNF20	2.04e-05	182	31	4	32239614
Pubmed	Identification of novel M phase phosphoproteins by expression cloning.	KIF20B DNAJC2	2.15e-05	8	31	2	8885239
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	PSMD4 RANBP2 CAPRIN1 GFPT1 MATR3 DNAJC2	2.34e-05	665	31	6	30457570
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	MANF PSMD4 ZNF830 EIF2A PPID CAPRIN1 NOS1AP	2.39e-05	1007	31	7	34597346
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	RANBP2 EIF2A PPID SUPT6H GFPT1 MATR3 RNF20	2.50e-05	1014	31	7	32416067
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	MANF PSMD4 RANBP2 EIF2A MATR3 DNAJC2	3.14e-05	701	31	6	30196744
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	PSMD4 RANBP2 EIF2A DHX37 GFPT1 RNF20	3.22e-05	704	31	6	29955894
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	RANBP2 EIF2A KDM5A CAPRIN1 DHX37 NOS1AP	3.76e-05	724	31	6	36232890
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	RANBP2 CAPRIN1 SUPT6H GFPT1 RNF20	4.10e-05	440	31	5	34244565
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RRP15 RANBP2 KDM5A GOLGA4 MATR3 RNF20	5.46e-05	774	31	6	15302935
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	PSMD4 CAPRIN1 DHX37 GFPT1 MATR3	5.55e-05	469	31	5	37314180
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	PSMD4 PPID CAPRIN1 GOLGA4 DNAJC2	5.72e-05	472	31	5	38943005
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	RRP15 PSMD4 RANBP2 CAPRIN1 DHX37	6.38e-05	483	31	5	36912080
Pubmed	Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.	CAPRIN1 MATR3 RNF20	6.46e-05	87	31	3	24169447
Pubmed	MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System.	MANF EIF2A	6.95e-05	14	31	2	32005751
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	RANBP2 PPP2R5A EIF2A DHX37	7.04e-05	250	31	4	33536335
Pubmed	Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.	RANBP2 PPID	8.02e-05	15	31	2	20676357
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	RRP15 PSMD4 RANBP2 CAPRIN1 SGK1 DHX37 MATR3	1.11e-04	1284	31	7	17353931
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PSMD4 UBASH3A KDM5A CAPRIN1 FRMD4B GFPT1 NUFIP1	1.12e-04	1285	31	7	35914814
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	RRP15 PSMD4 ZNF830 MATR3	1.14e-04	283	31	4	30585729
Pubmed	LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell function.	MATR3 RNF20	1.30e-04	19	31	2	31186351
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	RANBP2 GFPT1	1.60e-04	21	31	2	37422473
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	RRP15 C5 KDM5A CAPRIN1 DHX37 GFPT1 MATR3	1.67e-04	1371	31	7	36244648
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	MANF RRP15 RANBP2 ZNF830 KIF20B MATR3	1.72e-04	954	31	6	36373674
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	RRP15 CAPRIN1 DHX37 MATR3	1.73e-04	316	31	4	31665637
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	PSMD4 RANBP2 EIF2A CAPRIN1 GFPT1	1.86e-04	607	31	5	39147351
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	PSMD4 KAT2B EIF2A CAPRIN1 DHX37 MATR3	1.89e-04	971	31	6	33306668
Pubmed	Human transcription factor protein interaction networks.	RRP15 PSMD4 KAT2B KDM5A CAPRIN1 DHX37 MATR3	2.15e-04	1429	31	7	35140242
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MANF RRP15 RANBP2 OR10G8 KDM5A MATR3 CCDC158	2.27e-04	1442	31	7	35575683
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	RANBP2 EIF2A CAPRIN1 MATR3 DNAJC2	2.39e-04	641	31	5	36057605
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RANBP2 CAPRIN1 SUPT6H DHX37 GFPT1	2.61e-04	653	31	5	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	RRP15 RANBP2 CAPRIN1 GFPT1 MATR3	2.64e-04	655	31	5	35819319
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	PSMD4 RANBP2 CAPRIN1 MATR3 NOS1AP	2.74e-04	660	31	5	32780723
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	RRP15 EIF2A CAPRIN1 SUPT6H GOLGA4 DNAJC2 NOS1AP	2.74e-04	1487	31	7	33957083
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	PSMD4 GOLGA4 MATR3 RNF20	2.85e-04	360	31	4	33111431
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RRP15 RANBP2 EIF2A KDM5A SUPT6H KIF20B DNAJC2	2.86e-04	1497	31	7	31527615
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	MANF RANBP2 DNAJC2	2.93e-04	145	31	3	28846114
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	SGK1 FRMD4B GFPT1 SLC26A6	2.94e-04	363	31	4	14691545
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	RANBP2 PPP2R5A DHX37 KIF20B	3.16e-04	370	31	4	22922362
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	RANBP2 SUPT6H MATR3	3.23e-04	150	31	3	28242625
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	PSMD4 KIF20B NUFIP1 RNF20 TTC14	3.33e-04	689	31	5	36543142
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	MANF RANBP2 CAPRIN1 GFPT1 MATR3	3.85e-04	711	31	5	33022573
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	PSMD4 EIF2A CAPRIN1 GFPT1 MATR3	4.21e-04	725	31	5	27025967
Pubmed	Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.	ANKRD35 PPP2R5A	4.24e-04	34	31	2	25505242
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MANF PPID FRMD4B SLC26A6 GOLGA4	4.42e-04	733	31	5	34672954
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	RANBP2 DHX37 KIF20B MATR3	4.70e-04	411	31	4	35182466
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	RRP15 PSMD4 KDM5A CAPRIN1 MATR3 RNF20	4.74e-04	1153	31	6	29845934
Pubmed	Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.	C5 UBASH3A	5.02e-04	37	31	2	20453842
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RRP15 DHX37 KIF20B MATR3 NUFIP1	5.18e-04	759	31	5	35915203
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	RANBP2 CAPRIN1 MATR3	5.42e-04	179	31	3	36261009
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	PSMD4 CAPRIN1 MATR3	5.69e-04	182	31	3	31067453
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	PSMD4 CAPRIN1 MATR3 RNF20	6.12e-04	441	31	4	31239290
Pubmed	The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.	RANBP2 MATR3	6.47e-04	42	31	2	34244791
Pubmed	Mapping the Genetic Landscape of Human Cells.	PSMD4 ZNF830 DHX37 RNF20	6.65e-04	451	31	4	30033366
Pubmed	Dynamic protein-protein interaction wiring of the human spliceosome.	ZNF830 MATR3 TTC14	7.16e-04	197	31	3	22365833
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	RANBP2 SUPT6H MATR3 DNAJC2	8.07e-04	475	31	4	31040226
Pubmed	Identification of NPM-ALK interacting proteins by tandem mass spectrometry.	UBASH3A PPID	8.11e-04	47	31	2	14968112
Pubmed	MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis.	RANBP2 MATR3	8.45e-04	48	31	2	37438558
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	RRP15 RANBP2 CAPRIN1 DHX37 MATR3	8.50e-04	847	31	5	35850772
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	PSMD4 CAPRIN1 SUPT6H MATR3 RNF20	8.50e-04	847	31	5	35235311
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RRP15 RANBP2 KDM5A SUPT6H MATR3 RNF20	8.68e-04	1294	31	6	30804502
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	RANBP2 EIF2A PPID DHX37 GFPT1	8.78e-04	853	31	5	28718761
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	RRP15 SUPT6H DHX37	8.85e-04	212	31	3	33853758
Interaction	CTNNB1 interactions	ANKRD35 PSMD4 RANBP2 KAT2B PPP2R5A CAPRIN1 SGK1 GFPT1 MATR3	1.42e-05	1009	31	9	int:CTNNB1
Interaction	BIRC3 interactions	RRP15 PSMD4 RANBP2 CAPRIN1 SUPT6H DHX37 GFPT1 GOLGA4 MATR3 RNF20	1.92e-05	1334	31	10	int:BIRC3
Interaction	CDK9 interactions	RRP15 PSMD4 GFPT1 MATR3 NUFIP1 RNF20 TTC14	6.55e-05	685	31	7	int:CDK9
Interaction	PA2G4 interactions	EIF2A CAPRIN1 SGK1 DNAJC2 RNF20	6.75e-05	284	31	5	int:PA2G4
Interaction	TP63 interactions	KAT2B PPP2R5A UBASH3A CAPRIN1 GOLGA4	9.31e-05	304	31	5	int:TP63
Interaction	PIH1D1 interactions	RANBP2 EIF2A CAPRIN1 SUPT6H GFPT1 GOLGA4 MATR3	9.86e-05	731	31	7	int:PIH1D1
Interaction	SGF29 interactions	KAT2B GOLGA4 CCDC158 RNF20	1.12e-04	164	31	4	int:SGF29
Interaction	FMR1 interactions	RANBP2 KDM5A CAPRIN1 GOLGA4 MATR3 NUFIP1	1.44e-04	536	31	6	int:FMR1
Interaction	SMYD2 interactions	PSMD4 GFPT1 GOLGA4	1.48e-04	67	31	3	int:SMYD2
GeneFamily	Cyclophilin peptidylprolyl isomerases	RANBP2 PPID	1.58e-04	19	18	2	909
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RANBP2 PPID TTC14	1.91e-04	115	18	3	769
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	PSMD4 KAT2B PPP2R5A KDM5A SUPT6H SGK1 GFPT1 DNAJC2	1.87e-05	1024	31	8	M1742
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	PSMD4 KAT2B PPP2R5A KDM5A SUPT6H SGK1 GFPT1 DNAJC2	2.60e-05	1072	31	8	MM1031
Coexpression	GSE40274_CTRL_VS_LEF1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	PSMD4 RANBP2 GFPT1 MATR3	4.69e-05	170	31	4	M9091
Coexpression	GSE40493_BCL6_KO_VS_WT_TREG_UP	PSMD4 PPID SUPT6H GOLGA4	5.48e-05	177	31	4	M9401
Coexpression	GSE40666_UNTREATED_VS_IFNA_STIM_CD8_TCELL_90MIN_DN	ANKRD35 KAT2B EIF2A FRMD4B	8.64e-05	199	31	4	M9227
Coexpression	GSE46606_UNSTIM_VS_CD40L_IL2_IL5_1DAY_STIMULATED_IRF4MID_SORTED_BCELL_UP	ZNF830 PPP2R5A EIF2A DNAJC2	8.81e-05	200	31	4	M9833
Coexpression	GRUETZMANN_PANCREATIC_CANCER_DN	KAT2B C5 SGK1 GOLGA4	8.81e-05	200	31	4	M10431
Coexpression	IBRAHIM_NRF1_UP	MANF PSMD4 PPID GFPT1 DNAJC2	1.24e-04	420	31	5	M42509
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_UP	EIF2A GOLGA4 MATR3	1.34e-04	84	31	3	M15130
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_UP	EIF2A GOLGA4 MATR3	1.43e-04	86	31	3	MM825
Coexpression	UEDA_CENTRAL_CLOCK	MANF CAPRIN1 SGK1	1.64e-04	90	31	3	M2637
Coexpression	UEDA_CENTRAL_CLOCK	MANF CAPRIN1 SGK1	1.81e-04	93	31	3	MM1141
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	EIF2A KDM5A PPID DNAJC2	6.56e-06	176	31	4	3c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-Activated_T\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RANBP2 KAT2B GIMAP7 UBASH3A	8.69e-06	189	31	4	c38157c8cf5c0c1f560011ef5cc5892a049ee2b7
ToppCell	Caecum-Dendritic_cell-cycling_DCs\|Dendritic_cell / Region, Cell class and subclass	MANF ZNF830 GIMAP7 KIF20B	8.87e-06	190	31	4	54463f6f1718f22704175bd034f134de3b55d2eb
ToppCell	CTRL-Lymphoid-T_cell_&_NK_cell\|Lymphoid / Disease state, Lineage and Cell class	KAT2B GIMAP7 UBASH3A FRMD4B	9.05e-06	191	31	4	32381d353e40bce77a5b63c7bdbe360d27327d86
Drug	geldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A_EA	MANF KDM5A PPID SGK1 GFPT1	3.00e-06	174	30	5	972_UP
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA	MANF PPID SGK1 GFPT1	6.91e-05	169	30	4	1056_UP
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA	MANF PPID SGK1 GFPT1	7.39e-05	172	30	4	1064_UP
Drug	geldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A_EA	MANF KDM5A PPID GFPT1	7.73e-05	174	30	4	864_UP
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA	MANF PPID SGK1 GFPT1	7.73e-05	174	30	4	1063_UP
Drug	geldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A	MANF PPID GFPT1 NOS1AP	8.08e-05	176	30	4	5588_UP
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	MANF PPID GFPT1 NOS1AP	8.26e-05	177	30	4	6943_UP
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA	MANF PPID SGK1 GFPT1	8.63e-05	179	30	4	1005_UP
Drug	geldanamycin; Up 200; 1uM; MCF7; HG-U133A	MANF PPID SGK1 GFPT1	9.20e-05	182	30	4	593_UP
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA	MANF PPID SGK1 GFPT1	9.20e-05	182	30	4	998_UP
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	MANF PPID SGK1 GFPT1	9.40e-05	183	30	4	6937_UP
Drug	17-DMAG; Up 200; 0.1uM; MCF7; HT_HG-U133A	MANF PPID SGK1 GFPT1	1.11e-04	191	30	4	6933_UP
Drug	Rescinnamin [24815-24-5]; Down 200; 6.4uM; MCF7; HT_HG-U133A	KDM5A CAPRIN1 SUPT6H SGK1	1.13e-04	192	30	4	2785_DN
Drug	Naloxone hydrochloride [357-08-4]; Down 200; 11uM; PC3; HG-U133A	RRP15 PPP2R5A KIF20B MATR3	1.18e-04	194	30	4	1924_DN
Drug	Dipyridamole [58-32-2]; Down 200; 8uM; PC3; HG-U133A	RRP15 RANBP2 KIF20B MATR3	1.20e-04	195	30	4	1934_DN
Drug	Acetylsalicylsalicylic acid [530-75-6]; Up 200; 13.4uM; HL60; HG-U133A	KDM5A SUPT6H SGK1 GFPT1	1.27e-04	198	30	4	1377_UP
Disease	microcephaly (implicated_via_orthology)	DHX37 KIF20B	4.23e-04	32	28	2	DOID:10907 (implicated_via_orthology)
Disease	longitudinal BMI measurement	NOS1AP NUFIP1	2.75e-03	82	28	2	EFO_0005937
Disease	celiac disease	UBASH3A FRMD4B	6.36e-03	126	28	2	EFO_0001060
Disease	breast cancer (is_implicated_in)	MANF RNF20	8.90e-03	150	28	2	DOID:1612 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEAEIIKQLKIELKK	RNF20	621	Q5VTR2
KEAKIKELLKKLEQL	ANKRD35	926	Q8N283
IDKKLRNLEKKKGKL	CAPRIN1	61	Q14444
LLAKKEKDIQKKAIK	DNAJC2	336	Q99543
WKKVLPLLKIIKKKN	RANBP2	606	P49792
KKKLKKVDKIEELDQ	MATR3	711	P43243
VIIKKQKEIIKKLIE	KAT2B	661	Q92831
KKKLLDQEAKLKKEL	GOLGA4	971	Q13439
EDLKKKLINEKKEKL	KIF20B	581	Q96Q89
NKEVKKALLKLKDKV	OR10G8	291	Q8NGN5
KKVKELIEKEKEKDL	KDM5A	1091	P29375
DLKKLRVKELKKILD	MANF	131	P55145
EQKREKILELKKKEK	FRMD4B	421	Q9Y2L6
KILELKKKEKLLQEK	FRMD4B	426	Q9Y2L6
KKKEKLLQEKLLKKV	FRMD4B	431	Q9Y2L6
LLQEKLLKKVEELKK	FRMD4B	436	Q9Y2L6
SDPLIEKQKLKKKLK	C5	1036	P01031
LKELKILKDKKDAKI	CCDC158	606	Q5M9N0
KIKNLKKKLKAIEQL	EIF2A	536	Q9BY44
VKVILKKKKKLLLLQ	NOS1AP	81	O75052
KKKKKLLLLQKKEWT	NOS1AP	86	O75052
EKKVLQKILEQKEKK	DHX37	76	Q8IY37
EKDLVKLAKRLKKEK	PSMD4	121	P55036
KIQLIKKKGKVKALD	GFPT1	56	Q06210
KKKLLKKQEQLKLKQ	SLC26A6	576	Q9BXS9
ELLKVKQKIKAQKDK	PPID	346	Q08752
KEKEIKLLKLKYDEK	GIMAP7	246	Q8NHV1
VKVLQKKAILKKKEE	SGK1	126	O00141
KKLEELKLKKALEKQ	PPP2R5A	456	Q15172
KKLEELLIKTKKEKP	SUPT6H	1441	Q7KZ85
KKKLKLEKEKRGAVL	NUFIP1	256	Q9UHK0
EKLRKLLKEEKRLKK	TTC14	456	Q96N46
ILVKNKKLEKEKEKL	RRP15	111	Q9Y3B9
KKLEKEKEKLKQERL	RRP15	116	Q9Y3B9
KLKEILTIKELQKKE	ZNF830	331	Q96NB3
KLILEELKLEKKIKI	UBASH3A	491	P57075