Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNHD1 DNAH2 DNAH5 DNAH8

5.35e-06181334GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNHD1 DNAH2 DNAH5 DNAH8

3.40e-05281334GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNHD1 DNAH2 DNAH5 DNAH8

1.05e-04371334GO:0045505
GeneOntologyMolecularFunctionATP hydrolysis activity

MYH4 ABCC4 DNAH2 RFC5 ATAD2 ABCB4 MLH3 HFM1 DNAH5 DNAH8 FIGNL1

1.81e-0444113311GO:0016887
GeneOntologyMolecularFunctionATP-dependent activity

DNHD1 MYH4 ABCC4 DNAH2 RFC5 ATAD2 ABCB4 MLH3 HFM1 DNAH5 DNAH8 FIGNL1 TOP2A

2.36e-0461413313GO:0140657
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

TUBB8 TLN2 PLEC DMD TUBD1 TUBB8B

2.37e-041301336GO:0005200
GeneOntologyMolecularFunctionpyrophosphatase activity

PRUNE2 MYH4 NUGGC ABCC4 TUBB8 DNAH2 RFC5 ATAD2 ABCB4 MLH3 HFM1 DNAH5 DNAH8 FIGNL1 TUBB8B

4.76e-0483913315GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

PRUNE2 MYH4 NUGGC ABCC4 TUBB8 DNAH2 RFC5 ATAD2 ABCB4 MLH3 HFM1 DNAH5 DNAH8 FIGNL1 TUBB8B

4.82e-0484013315GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

PRUNE2 MYH4 NUGGC ABCC4 TUBB8 DNAH2 RFC5 ATAD2 ABCB4 MLH3 HFM1 DNAH5 DNAH8 FIGNL1 TUBB8B

4.82e-0484013315GO:0016818
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

MYH4 NUGGC ABCC4 TUBB8 DNAH2 RFC5 ATAD2 ABCB4 MLH3 HFM1 DNAH5 DNAH8 FIGNL1 TUBB8B

6.70e-0477513314GO:0017111
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization

TPR TUBB8 DNAH2 APC HAUS3 SIK3 CCNF HDAC3 BRCA2 SYNE2 PKD1 TUBD1 DNAH5 DNAH8 FIGNL1 TUBB8B

1.36e-0572013116GO:0000226
GeneOntologyCellularComponentaxonemal dynein complex

DNHD1 DNAH2 DNAH5 DNAH8

1.89e-05251354GO:0005858
GeneOntologyCellularComponentdynein complex

DNHD1 TPR DNAH2 DNAH5 DNAH8

2.56e-05541355GO:0030286
GeneOntologyCellularComponentmicrotubule associated complex

DNHD1 TPR DCTN5 DNAH2 HAUS3 DNAH5 DNAH8

8.56e-051611357GO:0005875
GeneOntologyCellularComponentcondensed chromosome

TPR DCTN5 APC MLH3 BRCA2 BUB1 SMARCD1 SMARCD2 TOP2A

1.75e-043071359GO:0000793
GeneOntologyCellularComponentsupramolecular fiber

LRRC39 MICAL1 MYH4 ENKUR EPPK1 TUBB8 LRRC49 CEP57L1 DNAH2 APC HAUS3 RYR3 SYNE2 PLEC DMD TUBD1 DNAH5 DNAH8 TUBB8B

2.08e-04117913519GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

LRRC39 MICAL1 MYH4 ENKUR EPPK1 TUBB8 LRRC49 CEP57L1 DNAH2 APC HAUS3 RYR3 SYNE2 PLEC DMD TUBD1 DNAH5 DNAH8 TUBB8B

2.27e-04118713519GO:0099081
GeneOntologyCellularComponentUBC13-MMS2 complex

UBE2V1 UBE2V2

2.46e-0441352GO:0031372
GeneOntologyCellularComponentdystrophin-associated glycoprotein complex

SGCB DMD UTRN

2.77e-04201353GO:0016010
GeneOntologyCellularComponentfilopodium membrane

SYNE2 DMD UTRN

3.22e-04211353GO:0031527
GeneOntologyCellularComponentchromosome, centromeric region

TPR DCTN5 APC ESCO2 BUB1 SMARCD1 SMARCD2 TOP2A

4.36e-042761358GO:0000775
GeneOntologyCellularComponentglycoprotein complex

SGCB DMD UTRN

5.46e-04251353GO:0090665
GeneOntologyCellularComponent9+0 motile cilium

ENKUR DNAH5

6.11e-0461352GO:0097728
GeneOntologyCellularComponentplatelet dense granule membrane

ABCC4 LAMP2

6.11e-0461352GO:0031088
GeneOntologyCellularComponentficolin-1-rich granule membrane

LAMP2 SERPINB6 SERPINB10 SLC11A1

6.53e-04611354GO:0101003
GeneOntologyCellularComponentmicrotubule

ENKUR TUBB8 LRRC49 CEP57L1 DNAH2 APC HAUS3 TUBD1 DNAH5 DNAH8 TUBB8B

6.95e-0453313511GO:0005874
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

MICAL1 ENKUR EPPK1 TUBB8 LRRC49 CEP57L1 DNAH2 APC HAUS3 PLEC DMD TUBD1 DNAH5 DNAH8 TUBB8B

7.11e-0489913515GO:0099513
GeneOntologyCellularComponentkinetochore

TPR DCTN5 APC BUB1 SMARCD1 SMARCD2

1.16e-031811356GO:0000776
GeneOntologyCellularComponentubiquitin conjugating enzyme complex

UBE2V1 UBE2V2

1.45e-0391352GO:0031371
GeneOntologyCellularComponentcondensed chromosome, centromeric region

TPR DCTN5 APC BUB1 SMARCD1 SMARCD2

1.61e-031931356GO:0000779
GeneOntologyCellularComponentchromosomal region

TPR DCTN5 APC ESCO2 BRCA2 BUB1 SMARCD1 SMARCD2 TOP2A

1.68e-034211359GO:0098687
GeneOntologyCellularComponentinner dynein arm

DNHD1 DNAH2

1.80e-03101352GO:0036156
GeneOntologyCellularComponenthemidesmosome

EPPK1 PLEC

2.19e-03111352GO:0030056
GeneOntologyCellularComponentouter dynein arm

DNAH5 DNAH8

2.62e-03121352GO:0036157
DomainSpectrin_repeat

SYNE2 PLEC DMD MCF2L UTRN

1.76e-06291335IPR002017
DomainDynein_HC_stalk

DNHD1 DNAH2 DNAH5 DNAH8

2.33e-06141334IPR024743
DomainDynein_heavy_dom-2

DNHD1 DNAH2 DNAH5 DNAH8

2.33e-06141334IPR013602
DomainDHC_N2

DNHD1 DNAH2 DNAH5 DNAH8

2.33e-06141334PF08393
DomainMT

DNHD1 DNAH2 DNAH5 DNAH8

2.33e-06141334PF12777
DomainSPEC

SYNE2 PLEC DMD MCF2L UTRN

2.93e-06321335SM00150
DomainSpectrin/alpha-actinin

SYNE2 PLEC DMD MCF2L UTRN

2.93e-06321335IPR018159
DomainDHC_fam

DNHD1 DNAH2 DNAH5 DNAH8

3.16e-06151334IPR026983
DomainDynein_heavy

DNHD1 DNAH2 DNAH5 DNAH8

3.16e-06151334PF03028
DomainDynein_heavy_dom

DNHD1 DNAH2 DNAH5 DNAH8

3.16e-06151334IPR004273
DomainAAA

ABCC4 DNAH2 RFC5 ATAD2 ABCB4 DNAH5 DNAH8 FIGNL1

8.94e-061441338SM00382
DomainAAA+_ATPase

ABCC4 DNAH2 RFC5 ATAD2 ABCB4 DNAH5 DNAH8 FIGNL1

8.94e-061441338IPR003593
DomainDHC_N1

DNAH2 DNAH5 DNAH8

1.93e-0581333PF08385
DomainDynein_heavy_dom-1

DNAH2 DNAH5 DNAH8

1.93e-0581333IPR013594
DomainSpectrin

SYNE2 DMD MCF2L UTRN

1.96e-05231334PF00435
DomainACTININ_2

SYNE2 PLEC DMD UTRN

1.96e-05231334PS00020
DomainACTININ_1

SYNE2 PLEC DMD UTRN

1.96e-05231334PS00019
DomainActinin_actin-bd_CS

SYNE2 PLEC DMD UTRN

1.96e-05231334IPR001589
DomainDystrophin

DMD UTRN

5.03e-0521332IPR016344
DomainCRAL_TRIO_2

PRUNE2 GDAP2 MCF2L

7.41e-05121333PF13716
DomainCH

MICAL1 SYNE2 PLEC DMD UTRN

9.96e-05651335SM00033
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH5 DNAH8

1.21e-04141333IPR024317
DomainATPase_dyneun-rel_AAA

DNAH2 DNAH5 DNAH8

1.21e-04141333IPR011704
DomainAAA_8

DNAH2 DNAH5 DNAH8

1.21e-04141333PF12780
DomainAAA_5

DNAH2 DNAH5 DNAH8

1.21e-04141333PF07728
DomainCH

MICAL1 SYNE2 PLEC DMD UTRN

1.42e-04701335PF00307
DomainAgo_hook

TNRC6B TNRC6A

1.50e-0431332PF10427
DomainSWIB_domain

SMARCD1 SMARCD2

1.50e-0431332IPR019835
DomainSWIB

SMARCD1 SMARCD2

1.50e-0431332SM00151
DomainTNRC6_PABC-bd

TNRC6B TNRC6A

1.50e-0431332IPR032226
DomainArgonaute_hook_dom

TNRC6B TNRC6A

1.50e-0431332IPR019486
DomainTNRC6-PABC_bdg

TNRC6B TNRC6A

1.50e-0431332PF16608
Domain-

MICAL1 SYNE2 PLEC DMD UTRN

1.52e-047113351.10.418.10
DomainCH

MICAL1 SYNE2 PLEC DMD UTRN

1.73e-04731335PS50021
DomainCH-domain

MICAL1 SYNE2 PLEC DMD UTRN

1.97e-04751335IPR001715
DomainKN_motif

KANK2 KANK1

2.99e-0441332IPR021939
DomainKN_motif

KANK2 KANK1

2.99e-0441332PF12075
DomainSWIB

SMARCD1 SMARCD2

4.96e-0451332PF02201
DomainSEC14

PRUNE2 GDAP2 MCF2L

7.24e-04251333SM00516
DomainLeu-rich_rpt

NLRP11 LRRC39 LRRC34 LRRC49 TLR8 CEP78 TLR1 PKD1

7.28e-042711338IPR001611
Domain-

EPPK1 PLEC

7.41e-04613323.90.1290.10
Domain-

SMARCD1 SMARCD2

7.41e-04613321.10.245.10
DomainEF-hand_dom_typ1

DMD UTRN

7.41e-0461332IPR015153
DomainEF-hand_dom_typ2

DMD UTRN

7.41e-0461332IPR015154
DomainEF-hand_2

DMD UTRN

7.41e-0461332PF09068
DomainEF-hand_3

DMD UTRN

7.41e-0461332PF09069
DomainSWIB_MDM2_domain

SMARCD1 SMARCD2

7.41e-0461332IPR003121
DomainCRAL_TRIO

PRUNE2 GDAP2 MCF2L

9.11e-04271333PS50191
DomainCRAL-TRIO_dom

PRUNE2 GDAP2 MCF2L

1.02e-03281333IPR001251
DomainPlectin

EPPK1 PLEC

1.03e-0371332PF00681
DomainPlectin_repeat

EPPK1 PLEC

1.03e-0371332IPR001101
DomainPLEC

EPPK1 PLEC

1.03e-0371332SM00250
Domain-

NLRP11 LRRC39 LRRC34 LRRC49 TLR8 CEP78 TLR1 PKD1

2.13e-0332113383.80.10.10
DomainL_dom-like

NLRP11 LRRC39 LRRC34 LRRC49 TLR8 CEP78 TLR1 PKD1

2.44e-033281338IPR032675
DomainPKD

TMEM130 PKD1

2.65e-03111332PS50093
DomainPKD_dom

TMEM130 PKD1

2.65e-03111332IPR000601
Domain-

TMEM130 PKD1

2.65e-031113322.60.40.670
DomainUQ_con

UBE2V1 UBE2V2 UBE2Z

2.68e-03391333PF00179
DomainARM

APC ARMCX2 AP1B1

2.88e-03401333SM00185
DomainUBIQUITIN_CONJUGAT_1

UBE2V1 UBE2V2 UBE2Z

2.88e-03401333PS00183
DomainUBIQUITIN_CONJUGAT_2

UBE2V1 UBE2V2 UBE2Z

3.09e-03411333PS50127
DomainUBQ-conjugat_E2

UBE2V1 UBE2V2 UBE2Z

3.09e-03411333IPR000608
DomainArmadillo

APC ARMCX2 AP1B1

4.55e-03471333IPR000225
DomainAAA

RFC5 ATAD2 FIGNL1

6.05e-03521333PF00004
DomainMAM

ZAN MALRD1

6.38e-03171332SM00137
DomainATPase_AAA_core

RFC5 ATAD2 FIGNL1

6.72e-03541333IPR003959
Domain-

DNHD1 NUGGC ABCC4 DNAH2 RFC5 ATAD2 ABCB4 CASK HFM1 DNAH5 DNAH8 FIGNL1

7.04e-03746133123.40.50.300
DomainLRR_6

NLRP11 LRRC34 CEP78

7.07e-03551333PF13516
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DCTN5 TUBB8 DNAH2 DNAH5 DNAH8

8.40e-0643925M47669
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DCTN5 TUBB8 DNAH2 DNAH5 DNAH8

1.05e-0545925M47670
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DCTN5 DNAH2 DNAH5 DNAH8

2.66e-0527924M47755
PathwayREACTOME_CELL_CYCLE

TPR TUBB8 HAUS3 RFC5 ESCO2 MLH3 CEP78 BRCA2 UBE2V2 SYNE2 BUB1 FIGNL1 TUBB8B TOP2A

1.53e-046949214M543
PathwayREACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS

TUBB8 GRIN2A CASK TUBB8B

1.89e-0444924M27934
PathwayWP_MYD88_DISTINCT_INPUTOUTPUT_PATHWAY

TLR8 UBE2V1 TLR1

2.04e-0418923M39478
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

TUBB8 TBC1D5 APC TNRC6B HAUS3 SIK3 ECPAS RFC5 KANK2 HDAC3 BRCA2 TNRC6A TMEM131 TANC1 PLEC TOP2A ZC3HAV1

4.35e-088531361728718761
Pubmed

Systemic investigation of bone and muscle abnormalities in dystrophin/utrophin double knockout mice during postnatal development and the mechanisms.

TNFSF11 DMD UTRN

2.33e-074136330689868
Pubmed

Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan.

PLEC DMD UTRN

2.33e-074136317389230
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TPR TBC1D5 DLGAP4 APC TNRC6B GRIN2A SIK3 GRM1 KANK2 CASK HDAC3 AP1B1 UBE2V1 UBE2V2 SYNE2 MIOS TLN2

2.43e-079631361728671696
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

FYTTD1 POLR1A DCTN5 TUBB8 APC TNRC6B LAMP2 RFC5 ATAD2 FOXJ3 KANK2 STAT1 CASK HDAC3 LNPEP TNRC6A MIOS TANC1 UTRN TBL2 ZC3HAV1

3.84e-0714971362131527615
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

NLRP11 DNHD1 TPR SLC15A1 PLEC DMD DNAH5 TOP2A ZC3HAV1

3.86e-07234136936243803
Pubmed

Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts.

SGCB DMD UTRN

5.82e-075136322427904
Pubmed

Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.

LAMP2 DMD UTRN

5.82e-075136320656885
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TPR LRRC49 APC TNRC6B ECPAS RBM20 BRCA2 BUB1 TNRC6A PLEC UTRN

8.42e-074181361134709266
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

FAT4 DNAH2 ALG11 SIK3 CSMD2 FOXJ3 RAD51AP2 AP1B1 SYNE2 SMARCD1 HFM1 MCF2L TBL2

1.45e-066381361331182584
Pubmed

Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle.

SGCB DMD UTRN

2.02e-06713631461282
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH2 DNAH5 DNAH8

2.02e-06713639256245
Pubmed

Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy.

SGCB DMD UTRN

2.02e-067136317475492
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH2 DNAH5 DNAH8

2.02e-067136331178125
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

TNRC6B LZIC KANK1 MAP4K5 NYNRIN BUB1 TNRC6A MIOS TANC1

5.35e-06322136939098523
Pubmed

Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.

CEP57L1 STAT1 MLH3 UBE2V2 TNRC6A FIGNL1 DKK3

6.36e-06176136727229929
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

DNHD1 TUBB8 SYNE2 PKD1 PLEC DMD DNAH8

9.45e-06187136726460568
Pubmed

miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway.

TNRC6A SMARCD2 DMD

1.25e-0512136325689854
Pubmed

Secreted TARSH regulates olfactory mitral cell dendritic complexity.

PRUNE2 ABI3BP TBX21

1.25e-0512136319302145
Pubmed

Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophy.

DMD UTRN

1.52e-052136210525423
Pubmed

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.

DMD UTRN

1.52e-052136228790199
Pubmed

Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy.

DMD UTRN

1.52e-052136225859846
Pubmed

G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain.

DMD UTRN

1.52e-05213627731967
Pubmed

Role of GW182 protein in the cell.

TNRC6B TNRC6A

1.52e-052136229791863
Pubmed

Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue.

DMD UTRN

1.52e-052136216710609
Pubmed

Nonclinical Exon Skipping Studies with 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn-/- Mice Inspired by Clinical Trial Results.

DMD UTRN

1.52e-052136230672725
Pubmed

Talin, vinculin and DRP (utrophin) concentrations are increased at mdx myotendinous junctions following onset of necrosis.

DMD UTRN

1.52e-05213627962191
Pubmed

Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.

KANK2 TLN2

1.52e-052136237460977
Pubmed

Contraction-Induced Loss of Plasmalemmal Electrophysiological Function Is Dependent on the Dystrophin Glycoprotein Complex.

SGCB DMD

1.52e-052136234764884
Pubmed

Does utrophin expression in muscles of mdx mice during postnatal development functionally compensate for dystrophin deficiency?

DMD UTRN

1.52e-05213628021701
Pubmed

Plakins in development and disease.

EPPK1 PLEC

1.52e-052136217499243
Pubmed

Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.

DMD UTRN

1.52e-052136226974331
Pubmed

Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy.

DMD UTRN

1.52e-052136228453658
Pubmed

A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin.

DMD UTRN

1.52e-052136211801396
Pubmed

Apo-dystrophin-1 and apo-dystrophin-2, products of the Duchenne muscular dystrophy locus: expression during mouse embryogenesis and in cultured cell lines.

DMD UTRN

1.52e-05213627987307
Pubmed

Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.

APC SLC15A1

1.52e-052136227458604
Pubmed

Comparative analysis of the human dystrophin and utrophin gene structures.

DMD UTRN

1.52e-052136211861579
Pubmed

Distinct mechanical properties in homologous spectrin-like repeats of utrophin.

DMD UTRN

1.52e-052136230914715
Pubmed

Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains.

DMD UTRN

1.52e-052136222284942
Pubmed

Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.

DMD UTRN

1.52e-052136217889902
Pubmed

Matricellular Protein CCN5 Gene Transfer Ameliorates Cardiac and Skeletal Dysfunction in mdx/utrn (±) Haploinsufficient Mice by Reducing Fibrosis and Upregulating Utrophin Expression.

DMD UTRN

1.52e-052136235557546
Pubmed

Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice.

DMD UTRN

1.52e-052136237626761
Pubmed

Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin.

DMD UTRN

1.52e-052136215565469
Pubmed

Fibrosis and inflammation are greater in muscles of beta-sarcoglycan-null mouse than mdx mouse.

SGCB DMD

1.52e-052136224723230
Pubmed

The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains.

DMD UTRN

1.52e-052136226516677
Pubmed

Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging.

DMD UTRN

1.52e-052136222209498
Pubmed

Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas.

AFP DKK3

1.52e-052136219437037
Pubmed

A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.

KANK2 KANK1

1.52e-052136231114072
Pubmed

A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET.

DMD UTRN

1.52e-052136237108685
Pubmed

Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene.

DMD UTRN

1.52e-052136210694796
Pubmed

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis.

TBX21 STAT1

1.52e-052136215238607
Pubmed

Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.

DMD UTRN

1.52e-052136224337461
Pubmed

Activation of calcineurin and stress activated protein kinase/p38-mitogen activated protein kinase in hearts of utrophin-dystrophin knockout mice.

DMD UTRN

1.52e-052136211297940
Pubmed

Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping.

DMD UTRN

1.52e-052136222388933
Pubmed

Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.

DMD UTRN

1.52e-052136225642938
Pubmed

Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice.

DMD UTRN

1.52e-052136215703201
Pubmed

Utrophin suppresses low frequency oscillations and coupled gating of mechanosensitive ion channels in dystrophic skeletal muscle.

DMD UTRN

1.52e-052136225941878
Pubmed

Duchenne muscular dystrophy and the neuromuscular junction: the utrophin link.

DMD UTRN

1.52e-05213629297964
Pubmed

SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.

DMD UTRN

1.52e-052136225652448
Pubmed

Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis.

DMD UTRN

1.52e-052136228785010
Pubmed

Restoration of all dystrophin protein interactions by functional domains in trans does not rescue dystrophy.

DMD UTRN

1.52e-052136216307000
Pubmed

Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice.

DMD UTRN

1.52e-052136221949353
Pubmed

Dystrophin and utrophin "double knockout" dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities.

DMD UTRN

1.52e-052136223097179
Pubmed

The role of utrophin and Dp71 for assembly of different dystrophin-associated protein complexes (DPCs) in the choroid plexus and microvasculature of the brain.

DMD UTRN

1.52e-052136215501597
Pubmed

Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice.

DMD UTRN

1.52e-052136211257121
Pubmed

Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice.

DMD UTRN

1.52e-052136218973234
Pubmed

Renin-angiotensin-aldosterone system inhibitors improve membrane stability and change gene-expression profiles in dystrophic skeletal muscles.

DMD UTRN

1.52e-052136227881412
Pubmed

Dystrophins, utrophins, and associated scaffolding complexes: role in mammalian brain and implications for therapeutic strategies.

DMD UTRN

1.52e-052136220625423
Pubmed

Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle.

DMD UTRN

1.52e-052136229065908
Pubmed

Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy.

DMD UTRN

1.52e-052136231039133
Pubmed

Developmentally regulated expression and localization of dystrophin and utrophin in the human fetal brain.

DMD UTRN

1.52e-052136211796130
Pubmed

Dystrophin and dystrophin-related protein in the brains of normal and mdx mice.

DMD UTRN

1.52e-05213628159184
Pubmed

Dystrophin and utrophin: genetic analyses of their role in skeletal muscle.

DMD UTRN

1.52e-052136210679963
Pubmed

TAT-μUtrophin mitigates the pathophysiology of dystrophin and utrophin double-knockout mice.

DMD UTRN

1.52e-052136221565990
Pubmed

Generation and characterization of transgenic mice with the full-length human DMD gene.

DMD UTRN

1.52e-052136218083704
Pubmed

Dystrophin and dystrophin-related protein (utrophin) distribution in normal and dystrophin-deficient skeletal muscles.

DMD UTRN

1.52e-05213628186702
Pubmed

Contemporary cardiac issues in Duchenne muscular dystrophy. Working Group of the National Heart, Lung, and Blood Institute in collaboration with Parent Project Muscular Dystrophy.

DMD UTRN

1.52e-052136225940966
Pubmed

Cardiac dysfunction and pathology in the dystrophin and utrophin-deficient mouse during development of dilated cardiomyopathy.

DMD UTRN

1.52e-052136222266080
Pubmed

Postnatal overexpression of the CT GalNAc transferase inhibits muscular dystrophy in mdx mice without altering muscle growth or neuromuscular development: evidence for a utrophin-independent mechanism.

DMD UTRN

1.52e-052136217300937
Pubmed

Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.

DMD UTRN

1.52e-052136221768542
Pubmed

Social stress is lethal in the mdx model of Duchenne muscular dystrophy.

DMD UTRN

1.52e-052136232192914
Pubmed

Alpha-fetoprotein and Fanconi Anemia: Relevance to DNA Repair and Breast Cancer Susceptibility.

BRCA2 AFP

1.52e-052136227690720
Pubmed

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity.

DMD UTRN

1.52e-052136233359740
Pubmed

Utrophin regulates modal gating of mechanosensitive ion channels in dystrophic skeletal muscle.

DMD UTRN

1.52e-052136224879867
Pubmed

Increased vulnerability to kainate-induced seizures in utrophin-knockout mice.

DMD UTRN

1.52e-052136212028357
Pubmed

Excitation-contraction coupling alterations in mdx and utrophin/dystrophin double knockout mice: a comparative study.

DMD UTRN

1.52e-052136220130206
Pubmed

Analysis of gene expression differences between utrophin/dystrophin-deficient vs mdx skeletal muscles reveals a specific upregulation of slow muscle genes in limb muscles.

DMD UTRN

1.52e-052136216525850
Pubmed

Persistent upregulation of the β-tubulin tubb6, linked to muscle regeneration, is a source of microtubule disorganization in dystrophic muscle.

SGCB DMD

1.52e-052136230535187
Pubmed

Distribution of dystrophin- and utrophin-associated protein complexes during activation of human neutrophils.

DMD UTRN

1.52e-052136220434517
Pubmed

Plasma lipidomic analysis shows a disease progression signature in mdx mice.

DMD UTRN

1.52e-052136234155298
Pubmed

Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice.

DMD UTRN

1.52e-052136224466085
Pubmed

ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner.

STAT1 ESCO2

1.52e-052136237968576
Pubmed

The Angiotensin Converting Enzyme Inhibitor Lisinopril Improves Muscle Histopathology but not Contractile Function in a Mouse Model of Duchenne Muscular Dystrophy.

DMD UTRN

1.52e-052136227110493
Pubmed

Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice.

DMD UTRN

1.52e-052136224781208
Pubmed

Isolation and characterization of a genomic clone from the murine utrophin locus.

DMD UTRN

1.52e-05213628268660
Pubmed

Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models.

DMD UTRN

1.52e-052136227037492
Pubmed

Improvement in survival and muscle function in an mdx/utrn(-/-) double mutant mouse using a human retinal dystrophin transgene.

DMD UTRN

1.52e-052136216487708
Pubmed

Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.

DMD UTRN

1.52e-052136221677768
Pubmed

Integrative effects of dystrophin loss on metabolic function of the mdx mouse.

SGCB DMD

1.52e-052136230206270
Pubmed

Consequences of the combined deficiency in dystrophin and utrophin on the mechanical properties and myosin composition of some limb and respiratory muscles of the mouse.

DMD UTRN

1.52e-05213629713852
InteractionPHF21A interactions

TPR LRRC49 APC TNRC6B ECPAS RBM20 ESCO2 BRCA2 BUB1 TNRC6A EXOC1 PLEC UTRN

4.98e-0734313413int:PHF21A
InteractionHDAC1 interactions

TPR MYH4 LRRC49 APC TNRC6B ECPAS SKIL TFAP4 RBM20 STAT1 ESCO2 CCNF HDAC3 BRCA2 SYNE2 BUB1 TNRC6A SMARCD1 SMARCD2 PLEC UTRN TOP2A

3.85e-06110813422int:HDAC1
InteractionLYN interactions

PRUNE2 SLC25A41 POLR1A APC LAMP2 KANK2 CASK CCNF HDAC3 LNPEP MAP4K5 TGDS TANC1 DMD TUBD1 UTRN ZC3HAV1

5.95e-0672013417int:LYN
Cytoband6q24

GRM1 UTRN

2.45e-04813726q24
Cytoband9q21.2

PRUNE2 CEP78

3.92e-041013729q21.2
GeneFamilyDyneins, axonemal

DNAH2 DNAH5 DNAH8

7.97e-0517913536
GeneFamilyAnkyrin repeat domain containing|KN motif and ankyrin repeat domain containing

KANK2 KANK1

1.49e-044912623
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6B CASK TNRC6A

2.62e-0425913775
GeneFamilyRho GTPase activating proteins|BCH domain containing

PRUNE2 GDAP2

5.18e-0479121299
GeneFamilyEF-hand domain containing|Plakins

EPPK1 PLEC

6.88e-048912939
GeneFamilyCyclins|F-boxes other

CCNF FBXO25 FBXO24

9.89e-0439913560
GeneFamilyCD molecules|Toll like receptors

TLR8 TLR1

1.10e-0310912948
GeneFamilyUbiquitin conjugating enzymes E2

UBE2V1 UBE2V2 UBE2Z

1.14e-0341913102
GeneFamilyAAA ATPases

RFC5 ATAD2 FIGNL1

2.41e-0353913413
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

DMD UTRN

3.64e-031891291
CoexpressionRODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP

TPR FYTTD1 APC HAUS3 ATAD2 LZIC BRCA2 LNPEP MAP4K5 MIOS PLEC FIGNL1 TOP2A DKK3

2.04e-0572113414M10237
CoexpressionMARKEY_RB1_ACUTE_LOF_UP

HAUS3 RFC5 CCNF BRCA2 TGDS BUB1 TNRC6A FIGNL1

3.11e-052371348M15606
CoexpressionMARKEY_RB1_ACUTE_LOF_UP

HAUS3 RFC5 CCNF BRCA2 TGDS BUB1 TNRC6A FIGNL1

3.40e-052401348MM976
CoexpressionHE_LIM_SUN_FETAL_LUNG_C5_PRO_B_CELL

CEP57L1 ATAD2 ESCO2 CCNF CEP78 BRCA2 SYNE2 BUB1 SMARCD2 FIGNL1 TOP2A

3.63e-0547813411M45785
CoexpressionDUTERTRE_ESTRADIOL_RESPONSE_24HR_UP

RFC5 ATAD2 TFAP4 ESCO2 CEP78 BRCA2 BUB1 FIGNL1 TOP2A

4.44e-053231349M2156
CoexpressionWHITFIELD_CELL_CYCLE_LITERATURE

CCNF BRCA2 BUB1 TOP2A

7.57e-05441344M2066
CoexpressionGSE2585_CTEC_VS_THYMIC_MACROPHAGE_DN

TBC1D5 APC ABCB4 BRCA2 LNPEP PLEC ZC3HAV1

7.61e-051991347M6264
CoexpressionGSE16385_ROSIGLITAZONE_IL4_VS_IL4_ALONE_STIM_MACROPHAGE_12H_DN

PRUNE2 ABCC4 ARMCX2 KANK1 TLR1 SMARCD1 UTRN

7.86e-052001347M8027
CoexpressionGSE43863_TH1_VS_LY6C_INT_CXCR5POS_EFFECTOR_CD4_TCELL_UP

LAMP2 GRIN2A RFC5 RYK HDAC3 UBE2V1 FIGNL1

7.86e-052001347M9764
CoexpressionGSE21670_TGFB_VS_TGFB_AND_IL6_TREATED_CD4_TCELL_UP

MICAL1 ABCC4 LRRC49 ATAD2 SERPINB6 SMARCD2 TBL2

7.86e-052001347M7433
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 ZAN GRM1 PKHD1L1 RYR3 TLN2 DMD DNAH5 ANO3

6.01e-0918413792cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 ZAN GRM1 PKHD1L1 RYR3 TLN2 DMD DNAH5 ANO3

6.01e-091841379ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 ZAN GRM1 PKHD1L1 RYR3 TLN2 DMD DNAH5 ANO3

6.01e-0918413792b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TEDC2 TBX21 RFC5 ATAD2 ESCO2 CCNF CEP78 BUB1 TOP2A

7.25e-091881379319fbeca200ab998daf49fcaee0bfdb57bf7ee4b
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 SYNE2 BUB1 TOP2A

1.19e-081991379305a9ade5bbe8e981e7c641c9a5e0c9f8ef60470
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 SYNE2 BUB1 TOP2A

1.19e-081991379fba48342066aab41a8bcb20db40a6df0158e1cbe
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT4 ABI3BP KANK2 GPC4 TLN2 DMD ANO3 DKK3

7.28e-0817513781799a7be623dc3bf53ba580a7c47d2619969d708
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CEP57L1 RFC5 ATAD2 ESCO2 CCNF BUB1 FIGNL1 TOP2A

1.12e-07185137847c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 ANO3 TOP2A

1.21e-071871378e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 ANO3 TOP2A

1.21e-071871378cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-T_NK_proliferative|Multiple_Sclerosis / Disease, Lineage and Cell Type

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.26e-0718813786c05797a5d0635d89ffcf4aca52178687129ccb4
ToppCell(02)_Cycling_Basal_(regeneration)|World / shred by cell type and Timepoint

RFC5 ATAD2 ESCO2 CCNF SERPINB10 BUB1 FIGNL1 TOP2A

1.37e-07190137853f017a11ca5ebe9025558e12cedc409cab2e5aa
ToppCellHealthy-T/NK_proliferative|World / disease group, cell group and cell class

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.81e-071971378e90be1e7e02f736b6aab14010a912b592d6f1e80
ToppCellCOVID-19_Severe-T/NK_proliferative|COVID-19_Severe / Disease condition and Cell class

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.81e-071971378718a84e9a8248080f2d964e7c6a3ba183ece9592
ToppCellCOVID-19_Moderate-T/NK_proliferative|COVID-19_Moderate / disease group, cell group and cell class

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.88e-071981378166c000fb0e19602ffdd8bf2b2f19be2c6df96a6
ToppCellCOVID-19_Moderate-T/NK_proliferative|World / disease group, cell group and cell class

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.88e-071981378bf0131fbca6032e1aab4aa807f8c1d3be689cb7f
ToppCellCOVID-19_Severe-T/NK_proliferative|World / disease group, cell group and cell class

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.88e-07198137848045689d0969ff0a14eee7086b8e19b0d6b6065
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-07199137811c3d9fe811a4619347f47d2b0e94066e3085625
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-071991378e98ff036d04fc78dffef156bdc0d644532274067
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-07199137836c80907b2ec1cbcd1b4e841e6c02a4792591d74
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-071991378bf4c31902ae8358215245a2e11b5a2fe4ca1bc8c
ToppCellCOVID-19_Mild-Lymphoid_T/NK-T/NK_proliferative|COVID-19_Mild / Disease group, lineage and cell class

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-071991378ddea0e5c1cb6a096ab8e09a8c3c37c1bff381d9c
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-0719913787feedb0bf84a3361c8ab5b6674ff64e8ff140c23
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-0719913787beb0e07a27fea94674f24eb61c381b0de38ed3e
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-071991378123fbf2122aa221d8cbf3aef9361ba0982c07695
ToppCellCOVID-19_Mild-T/NK_proliferative|COVID-19_Mild / Disease condition and Cell class

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-0719913789f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCellCOVID-19_Severe-Lymphoid_T/NK-T/NK_proliferative|COVID-19_Severe / Disease group, lineage and cell class

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-071991378ddae7fe7633661f15d3c79f5187415ffbfecce67
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEDC2 RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.95e-0719913786b1304417cf9c44ca70d2bfc2b5acc1a206f25b6
ToppCellmild-T/NK_proliferative|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RFC5 ATAD2 ESCO2 CCNF CEP78 BRCA2 BUB1 TOP2A

2.03e-07200137863cc57b9331459efbb73051d174d198a3568b938
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.07e-0617213776fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATAD2 ESCO2 SERPINB10 BRCA2 BUB1 FIGNL1 TOP2A

1.16e-06174137746cbb462173a684ceb9e680f9259dc3b133763f7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TEDC2 CSMD2 ATAD2 ESCO2 CEP78 BRCA2 TOP2A

1.40e-06179137780112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TEDC2 CSMD2 ATAD2 ESCO2 BRCA2 BUB1 TOP2A

1.45e-061801377f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRUNE2 ESCO2 CCNF AFP BUB1 FIGNL1 TOP2A

1.74e-06185137757c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCellControl-T_cells-Cycling_NK/T_cells|Control / group, cell type (main and fine annotations)

NUGGC ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

1.74e-0618513779766216b41ee62bbac4caa25cb98ec5627a24075
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 ABCC4 KANK1 SYNE2 GPC4 TLN2 NRG3

1.80e-061861377b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

TNRC6B SIK3 LNPEP SYNE2 TMEM131 UTRN ZC3HAV1

1.93e-061881377ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellNS-critical-d_0-4-Lymphoid-NKT-proliferating|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CEP57L1 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.00e-061891377d6bd46abb072b13a6b72f1ca25d19f218cceb1ff
ToppCellPBMC-Severe-cDC_12|Severe / Compartment, Disease Groups and Clusters

TEDC2 CEP57L1 ATAD2 CEP78 BRCA2 BUB1 TOP2A

2.08e-06190137784ee185939bdefb10705b621a70da27701eadcee
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBM20 ESCO2 CCNF BUB1 DNAH8 FIGNL1 TOP2A

2.08e-061901377b99271d139c8d01e20feb95d99f79c9b2756b4cb
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.08e-061901377d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T|GI_small-bowel / Manually curated celltypes from each tissue

TEDC2 ATAD2 KANK2 ESCO2 BRCA2 BUB1 TOP2A

2.15e-061911377e642fa7395c05fb53324c9d46bbc52f89fc9673f
ToppCellfacs-Thymus-Flowthrough-3m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAUS3 RFC5 ATAD2 CCNF BUB1 FIGNL1 TOP2A

2.23e-061921377e8d47504b744040a762ec9b670a66cc060b2ae86
ToppCellPSB-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TEDC2 ATAD2 KANK2 CEP78 BRCA2 BUB1 TOP2A

2.30e-061931377b7d9c5bed524423e92f01496a9f8fad11b33a3f7
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.38e-061941377f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCellP28-Mesenchymal-myocytic_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLIN4 GRIN2A SLC11A1 GPC4 COL14A1 DMD DKK3

2.38e-06194137783e45441c74b7f50b6725876b583229280179dc2
ToppCellControl-Lymphoid_T/NK-T/NK_proliferative|Control / Disease group, lineage and cell class

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.38e-0619413779bbb124001fba7450f4639f47f9b720a483e7242
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.38e-061941377a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.38e-06194137717744fd6645cf5a447a01a83f07e8d305c2bcd9c
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.38e-061941377e14f66f7584909621b776292fbd52808273fd2ee
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RFC5 ATAD2 ESCO2 CCNF BUB1 FIGNL1 TOP2A

2.47e-0619513777ae732f100e9a3c6062be5b877efa1ec9d5b3958
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HAUS3 RFC5 ESCO2 CCNF BUB1 FIGNL1 TOP2A

2.47e-06195137797b2ff072cc830a4a2cb217f5a215ca6cad505ec
ToppCell(1)_T_cells-(1)_T_cells_Dividing|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.47e-061951377cf00a0b4f341f0487d5b37810abe2952fdd3f6f2
ToppCellmild-Lymphocytic-Prol._cells|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.47e-0619513779a8cc9097a349fd0a53ccf2723ee8bb1418d6aca
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RFC5 ATAD2 ESCO2 CCNF BUB1 FIGNL1 TOP2A

2.47e-061951377043e2f19d95e94cd5219e2c415f322ed340aa80f
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.55e-0619613779591a6a3477ed6a1e2e016f7542e38603d8b16cb
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TEDC2 RFC5 ATAD2 ESCO2 BRCA2 FIGNL1 TOP2A

2.55e-061961377df366d76ea55f49e349d622effa57c1535df8400
ToppCellmild-Lymphocytic-Prol._cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.55e-061961377b1d9866d5dfaefdb8bedaf01a750d97987acb3d1
ToppCellHealthy-T/NK_proliferative|Healthy / disease group, cell group and cell class

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.55e-06196137791e44aabb2e85dcc77ddae6f7e000118d45d1de6
ToppCellControl-T/NK_proliferative|Control / Disease condition and Cell class

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.55e-0619613777b7bc25aef49bfd64f79303a92d527bf8188f7a6
ToppCellICU-SEP-Lymphocyte-T_NK-T_NK_proliferative|ICU-SEP / Disease, Lineage and Cell Type

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.64e-061971377908e91fa16134b61943aea5e8fc0d6fbac8a8c6e
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZAN ABI3BP PKHD1L1 ESCO2 BRCA2 BUB1 TOP2A

2.64e-06197137776b61e60a757e58b465569538e632d6d9953e89a
ToppCelldistal-mesenchymal-Vascular_Smooth_Muscle-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KANK2 RBM20 RANBP3L GPC4 COL14A1 DMD DKK3

2.64e-061971377da653dc7d216e202f390e5ab0245f243e3ed213b
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RFC5 ATAD2 ESCO2 CCNF BUB1 FIGNL1 TOP2A

2.64e-061971377a0d463825b62de49466f9fa563405dda4387cfff
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_NK-Cycling_NK|lymph-node_spleen / Manually curated celltypes from each tissue

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.73e-061981377b2868a897dd96494cf1829c30e0ce508f52efdf3
ToppCellsevere_COVID-19-T/NK_proliferative|severe_COVID-19 / disease group, cell group and cell class (v2)

TEDC2 RFC5 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.73e-061981377ed86b0247006befe55400c287d334d2202b470bd
ToppCell(3)_DC_Monocyte_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.73e-061981377e2b89f6d7c0007ccab62495cd543fe0e5513a9a4
ToppCelldistal-1-Hematologic-Proliferating_Macrophage|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.73e-061981377df3f5559ecd1f3cd1fd60e39dbad8741309e83a3
ToppCelldistal-Hematologic-Proliferating_Macrophage-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.73e-0619813772b0716e900bce54ad1825d6dcdaf4ebf31f355c4
ToppCellcycling_basal_cell|World / shred by cell class for turbinate

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.73e-061981377e86c1224f5b0890a50a25257628e90c790aae7cd
ToppCellLeuk-UTI-Lymphocyte-T_NK-T_NK_proliferative|Leuk-UTI / Disease, Lineage and Cell Type

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.82e-06199137787113d398585076ece86b9098781e817f8ca241b
ToppCellVE-cycling|VE / Condition, Cell_class and T cell subcluster

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.82e-06199137747c47ebc318a0b98841ca2656837bbd068899559
ToppCell3'_v3-bone_marrow-Lymphocytic_NK-Cycling_NK|bone_marrow / Manually curated celltypes from each tissue

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.82e-0619913776321140a1ebc1ff793fb6221a31e884368e42fa5
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

TEDC2 ATAD2 ESCO2 BRCA2 SYNE2 BUB1 TOP2A

2.82e-061991377101f78fe6dd1bf9e2e4dd5ad8a970312b3540927
ToppCellNS-critical-d_16-33-Lymphoid-NKT-proliferating|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NUGGC TEDC2 ATAD2 ESCO2 CCNF BUB1 TOP2A

2.82e-06199137731b144bb209c629e12156f4d9c9cec79baffffb9
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEDC2 ATAD2 ESCO2 BRCA2 SYNE2 BUB1 TOP2A

2.82e-061991377e0fcec796afe75e42467ca86355b9fc5aa9ae0a1
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.82e-06199137788d130e2451e61afb710edf552e6b346b9fcfb2b
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

TBC1D5 TNRC6B BCKDHB SIK3 TNRC6A DMD UTRN

2.82e-06199137794b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATAD2 ESCO2 CCNF BRCA2 BUB1 NRG3 TOP2A

2.82e-0619913771d5a3366474c17e3df0ba5cf11b586655529e9bd
ToppCellVE-cycling-|VE / Condition, Cell_class and T cell subcluster

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.82e-061991377c0a67149a19b65b3069dbc5261d81f658e6e39a2
ToppCellCOVID-19_Severe-T/NK_proliferative|COVID-19_Severe / disease group, cell group and cell class

TEDC2 RFC5 ATAD2 ESCO2 CCNF BUB1 TOP2A

2.82e-061991377af78837f3a7641a5bd98765eef9cb4f86034048c
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ATAD2 ESCO2 CCNF BRCA2 SYNE2 BUB1 TOP2A

2.82e-061991377be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCellmild_COVID-19-T/NK_proliferative|mild_COVID-19 / disease group, cell group and cell class (v2)

TEDC2 RFC5 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.82e-061991377df2fcaf01b1b48632f84e7355ef21d20853f0664
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

FAT4 RYK STAT1 TMEM131 DMD UTRN TOP2A

2.82e-061991377358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-T/NK_proliferative|COVID-19_Mild / Disease, condition lineage and cell class

RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.91e-0620013776126a3bbafe2110fba0c1c4493035df4e8193d22
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ENKUR ATAD2 ESCO2 BRCA2 BUB1 GPC4 TOP2A

2.91e-06200137731dd81df9aa754a1e69b905bf9b8ce73ff8175aa
ToppCellControl_saline-Endothelial-Endothelial-FOXM1|Control_saline / Treatment groups by lineage, cell group, cell type

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.91e-0620013779bbc7b5561151f6ff65f40b3226271def732e5d9
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Stem_cells-Neuroepithelial_cell|5w / Sample Type, Dataset, Time_group, and Cell type.

TEDC2 RFC5 ATAD2 ESCO2 BRCA2 BUB1 TOP2A

2.91e-062001377c865efaaaecccbf9c833d6c1cbe85809a3ec306d
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-T/NK_proliferative|COVID-19_Severe / Disease, condition lineage and cell class

RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.91e-0620013770892603e604c2a945dd720685d45970f855bd5d3
ToppCellhealthy_donor-Lymphocytic-Proliferative_Lymphocyte|healthy_donor / Disease condition, Lineage, Cell class and subclass

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.91e-062001377e4eb915c29909cf8535a3603c68976545c05e54b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells-Neuroepithelial_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ENKUR ATAD2 ESCO2 BRCA2 BUB1 GPC4 TOP2A

2.91e-06200137754174a485a82480726fa06efa6e050ddea77cb3c
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Stem_cells|5w / Sample Type, Dataset, Time_group, and Cell type.

TEDC2 RFC5 ATAD2 ESCO2 BRCA2 BUB1 TOP2A

2.91e-0620013772ee167b8bddd11fd5b1f61f87fcdf757aee3193e
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Stem_cells-Stem_cells|GW09 / Sample Type, Dataset, Time_group, and Cell type.

RFC5 ATAD2 ESCO2 SYNE2 GPC4 UTRN TOP2A

2.91e-062001377c00cc0b91baa37828895d9d6b8acbc6aa503215a
ToppCellmild-T/NK_proliferative|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.91e-06200137725b4a1a33348e274bd4457efc0d6faa5421c3d31
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Stem_cells|GW09 / Sample Type, Dataset, Time_group, and Cell type.

RFC5 ATAD2 ESCO2 SYNE2 GPC4 UTRN TOP2A

2.91e-0620013779e1b62a703fb7d413ce580448a1df5127c28e8a7
ToppCellhealthy_donor-Lymphocytic-Proliferative_Lymphocyte-|healthy_donor / Disease condition, Lineage, Cell class and subclass

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.91e-062001377415e7556b5ac45688e2c6c30a52bd40e0eb27c7d
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

PRUNE2 ABI3BP KANK2 MAP4K5 GPC4 DMD DKK3

2.91e-062001377593bf6a7c557437db9a9249a5058a46014179ef6
ToppCellMS-Multiple_Sclerosis-Lymphocyte-T/NK-T/NK_proliferative|Multiple_Sclerosis / Disease, condition lineage and cell class

RFC5 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.91e-0620013777faf1e37364203a08d2b2544979e848b41e36b1c
ToppCellNS-critical-d_07-13-Lymphoid-NKT-proliferating|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TEDC2 ATAD2 ESCO2 CCNF BRCA2 BUB1 TOP2A

2.91e-0620013777f5cd05bb1b9a83baceddb7d7f0a9ec9781cda29
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

PRUNE2 ABI3BP KANK2 MAP4K5 GPC4 DMD DKK3

2.91e-06200137702cae2c296a13ad4cbb53bca7a86d64629d67d66
DrugAdamantamine fumarate [80789-67-9]; Down 200; 9.6uM; HL60; HT_HG-U133A

DCTN5 TBC1D5 ECPAS RFC5 RYK STAT1 SERPINB10 BRCA2 PLEC UTRN

1.43e-07184134101344_DN
Diseaselevel of Ceramide (d40:1) in blood serum

SIK3 MAP4K5 SYNE2

1.34e-05111303OBA_2045185
Diseasefactor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement

MAP4K5 PLEC MCF2L TBL2

1.11e-04561304EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Diseasebreast cancer (implicated_via_orthology)

APC STAT1 BRCA2

1.79e-04251303DOID:1612 (implicated_via_orthology)
Diseasereticulocyte count

ENKUR TNRC6B KANK2 STAT1 ABCB4 AP1B1 RANBP3L MAP4K5 SYNE2 PKD1 TLN2 TMEM131 UBE2Z ZC3HAV1

2.16e-04104513014EFO_0007986
DiseaseColorectal cancer

APC MLH3 BUB1

2.26e-04271303cv:C0346629
DiseaseCOLORECTAL CANCER

APC MLH3 BUB1

2.26e-04271303114500
DiseaseNeoplasm of the large intestine

APC MLH3 BUB1

2.26e-04271303cv:C0009404
Diseasereticulocyte measurement

ENKUR TNRC6B ECPAS KANK2 STAT1 ABCB4 AP1B1 RANBP3L MAP4K5 SYNE2 TLN2 TMEM131 UBE2Z ZC3HAV1

2.34e-04105313014EFO_0010700
Diseasesusceptibility to mononucleosis measurement

FAT4 DNAH2 DMD DNAH8

2.49e-04691304EFO_0008403
Diseaseneuroimaging measurement

TBC1D5 LRRC49 APC TNRC6B RFC5 TFAP4 STAT1 PKD1 TNRC6A TLN2 PLEC TUBD1 TBL2 UBE2Z

2.72e-04106913014EFO_0004346
DiseaseWILMS TUMOR 1

BRCA2 GPC4

2.86e-0461302194070
DiseaseWilms tumor 1

BRCA2 GPC4

2.86e-0461302cv:CN033288
Diseasecalcium measurement

ABCC4 DNAH2 SIK3 NFU1 MAP4K5 NYNRIN SYNE2 HFM1 TMEM131 PLEC

4.81e-0462813010EFO_0004838
Diseaseresting heart rate

EPPK1 LZIC MAP4K5 TANC1 PLEC

5.29e-041491305EFO_0004351
DiseaseNephroblastoma

BRCA2 GPC4

5.30e-0481302cv:C0027708
DiseaseLeprosy

SLC11A1 TLR1

5.30e-0481302C0023343
Diseaseleprosy (is_implicated_in)

SLC11A1 TLR1

5.30e-0481302DOID:1024 (is_implicated_in)
DiseaseHereditary Wilms tumor

BRCA2 GPC4

5.30e-0481302cv:C0677779
DiseaseKidney Wilms tumor

BRCA2 GPC4

5.30e-0481302cv:CN305775
Diseaseendometrial cancer (is_implicated_in)

APC MLH3 BRCA2

5.36e-04361303DOID:1380 (is_implicated_in)
DiseaseLynch Syndrome

APC MLH3

6.80e-0491302C4552100
Diseasecystic fibrosis (implicated_via_orthology)

ABCC4 ABCB4

6.80e-0491302DOID:1485 (implicated_via_orthology)
DiseaseCoffin-Siris syndrome (implicated_via_orthology)

SMARCD1 SMARCD2

6.80e-0491302DOID:1925 (implicated_via_orthology)
Diseasecholestasis (implicated_via_orthology)

LAMP2 ABCB4

6.80e-0491302DOID:13580 (implicated_via_orthology)
Diseasemedulloblastoma (is_implicated_in)

APC BRCA2

8.47e-04101302DOID:0050902 (is_implicated_in)
Diseaseptosis (implicated_via_orthology)

TUBB8 TUBB8B

8.47e-04101302DOID:0060260 (implicated_via_orthology)
Diseasetubulinopathy (implicated_via_orthology)

TUBB8 TUBB8B

8.47e-04101302DOID:0112227 (implicated_via_orthology)
Diseaselevel of Triacylglycerol (51:3) in blood serum

SIK3 MAP4K5

8.47e-04101302OBA_2045163
Diseasefacial paralysis (implicated_via_orthology)

TUBB8 TUBB8B

8.47e-04101302DOID:13934 (implicated_via_orthology)
Diseasecomplex cortical dysplasia with other brain malformations 7 (implicated_via_orthology)

TUBB8 TUBB8B

8.47e-04101302DOID:0090132 (implicated_via_orthology)
Diseasetriglycerides in large LDL measurement

SIK3 MAP4K5 SYNE2

9.07e-04431303EFO_0022319
Diseaselevel of Diacylglycerol (18:1_18:1) in blood serum

SIK3 MAP4K5

1.03e-03111302OBA_2045170
Diseaseinsulin sensitivity measurement, response to polyunsaturated fatty acid supplementation

TNRC6B TLN2

1.03e-03111302EFO_0004471, EFO_0009131
DiseaseMalignant neoplasm of kidney

ESCO2 BRCA2 FIGNL1

1.04e-03451303C0740457
Diseasecerebellar ataxia, mental retardation and dysequlibrium syndrome (implicated_via_orthology)

TUBB8 TUBB8B

1.24e-03121302DOID:0050997 (implicated_via_orthology)
Diseasealpha-hydroxybutyric acid measurement

ABCC4 MAP4K5

1.24e-03121302EFO_0010458
Diseaselevel of Diacylglycerol (18:1_18:2) in blood serum

SIK3 MAP4K5

1.24e-03121302OBA_2045171
Diseaseomega-6:omega-3 polyunsaturated fatty acid ratio

MAP4K5 HFM1 NRG3

1.41e-03501303EFO_0010732
DiseaseBenign tumor of pancreas

APC BRCA2

1.46e-03131302C0347284
DiseaseColorectal Neoplasms

ABCC4 APC GRIN2A ABCB4 MLH3 BUB1

1.46e-032771306C0009404
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

BRCA2 MAP4K5 NYNRIN SYNE2

1.50e-031111304EFO_0004530, EFO_0008595
Diseasefree cholesterol to total lipids in small LDL percentage

SIK3 MAP4K5 TGDS

1.67e-03531303EFO_0022286
DiseaseKartagener syndrome (implicated_via_orthology)

AP1B1 DNAH5

1.69e-03141302DOID:0050144 (implicated_via_orthology)
Diseasefactor VII measurement

MAP4K5 MCF2L TBL2

1.85e-03551303EFO_0004619
DiseaseLiver carcinoma

TEDC2 APC STAT1 ABCB4 CCNF AFP BUB1 TOP2A

1.88e-035071308C2239176
Diseasetriacylglycerol 52:3 measurement

SIK3 MAP4K5

1.95e-03151302EFO_0010415
Diseaselevel of Triacylglycerol (53:3) in blood serum

SIK3 MAP4K5

1.95e-03151302OBA_2045165
Diseasetriglycerides in LDL measurement

SIK3 MAP4K5 SYNE2

1.95e-03561303EFO_0022320
Diseasetriglycerides in chylomicrons and extremely large VLDL measurement

SIK3 MAP4K5 TGDS

1.95e-03561303EFO_0022316
Diseasecolorectal cancer (is_implicated_in)

APC GRIN2A MLH3 BUB1

2.05e-031211304DOID:9256 (is_implicated_in)
Diseasefibrinogen measurement, factor VII measurement

MAP4K5 PLEC MCF2L

2.16e-03581303EFO_0004619, EFO_0004623
DiseaseIntrahepatic cholestasis of pregnancy

ABCB4 MAP4K5

2.22e-03161302EFO_0009048
Diseaseconcentration of chylomicrons and extremely large VLDL particles measurement

SIK3 MAP4K5 TGDS

2.27e-03591303EFO_0022260
Diseasecholesterol in chylomicrons and extremely large VLDL measurement

SIK3 MAP4K5 TGDS

2.38e-03601303EFO_0021898
Diseaseunipolar depression, response to selective serotonin reuptake inhibitor, mood disorder

FSTL4 BPNT2

2.51e-03171302EFO_0003761, EFO_0004247, EFO_0005658
Diseasetotal lipids in chylomicrons and extremely large VLDL measurement

SIK3 MAP4K5 TGDS

2.61e-03621303EFO_0022306
Diseasefree cholesterol in chylomicrons and extremely large VLDL measurement

SIK3 MAP4K5 TGDS

2.61e-03621303EFO_0022263
DiseaseCardiomyopathies

SGCB LAMP2 RBM20 DMD

2.66e-031301304C0878544
Diseasefree cholesterol to total lipids in medium LDL percentage

SIK3 MAP4K5 TGDS

2.74e-03631303EFO_0022283
Diseasephospholipids in chylomicrons and extremely large VLDL measurement

SIK3 MAP4K5 TGDS

2.74e-03631303EFO_0022292
Diseaseapolipoprotein B measurement

TBX21 SIK3 KANK2 ABCB4 BRCA2 MAP4K5 NYNRIN SYNE2 PLEC

2.74e-036631309EFO_0004615
Diseasebitter alcoholic beverage consumption measurement

DNAH2 TNRC6B MAP4K5 TNRC6A

2.89e-031331304EFO_0010092
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

AP1B1 DNAH5

3.14e-03191302DOID:9562 (implicated_via_orthology)
DiseasePancreatic carcinoma

APC BRCA2

3.14e-03191302C0235974
DiseaseHypertriglyceridemia

MAP4K5 TBL2

3.14e-03191302EFO_0004211
DiseaseCholecystitis

ABCB4 MAP4K5

3.14e-03191302HP_0001082
DiseaseGrand Mal Status Epilepticus

LAMP2 GRM1 DMD

3.26e-03671303C0311335
DiseaseStatus Epilepticus, Subclinical

LAMP2 GRM1 DMD

3.26e-03671303C0751522
DiseaseSimple Partial Status Epilepticus

LAMP2 GRM1 DMD

3.26e-03671303C0751524
DiseaseNon-Convulsive Status Epilepticus

LAMP2 GRM1 DMD

3.26e-03671303C0751523
DiseasePetit mal status

LAMP2 GRM1 DMD

3.26e-03671303C0270823
DiseaseComplex Partial Status Epilepticus

LAMP2 GRM1 DMD

3.26e-03671303C0393734
DiseaseStatus Epilepticus

LAMP2 GRM1 DMD

3.40e-03681303C0038220
Diseaseforced expiratory volume, response to bronchodilator

EPPK1 ABI3BP FSTL4 SIK3 FCER2 PLEC DNAH5

3.65e-034451307EFO_0004314, GO_0097366
Diseasemuscular dystrophy (implicated_via_orthology)

DMD UTRN

3.83e-03211302DOID:9884 (implicated_via_orthology)
Diseaseprothrombin time measurement

MAP4K5 MCF2L

3.83e-03211302EFO_0008390
DiseaseColorectal Carcinoma

ABCC4 APC GRIN2A GRM1 ABCB4 MLH3 BUB1 DMD DNAH8

3.99e-037021309C0009402
Diseasetestosterone measurement

POLR1A ZAN DLGAP4 DNAH2 RYK UBE3D MAP4K5 NYNRIN SYNE2 TGDS C18orf63 UTRN TBL2

4.19e-03127513013EFO_0004908
Diseaseamblyopia

BCKDHB MALRD1

4.20e-03221302MONDO_0001020
Diseasetriacylglycerol 54:6 measurement

SIK3 MAP4K5

4.20e-03221302EFO_0010424
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

PRUNE2 EPPK1 ABCB4 NYNRIN PLEC

4.22e-032391305EFO_0010934

Protein segments in the cluster

PeptideGeneStartEntry
MLSVVKNQNIGFNNA

ALG11

206

Q2TAA5
QVLNQMITSKSNPGN

BUB1

166

O43683
VTGFQVANSKVNATM

CSMD2

3296

Q7Z408
KGMFAINQVTGQLTT

FAT4

836

Q6V0I7
QVGSISMDLQLTNKA

AP1B1

741

Q10567
GVNQSMLFDKLITNT

ATAD2

166

Q6PL18
ALGQMQNIQFQKITG

CEP78

591

Q5JTW2
NIMAGLQQTNSEKIL

DMD

126

P11532
SGKSLSMFQQQLEQS

DNHD1

3171

Q96M86
IAEMQGKLATFQNQI

CCDC154

526

A6NI56
VGSAQLLMSQKFQQF

DLGAP4

846

Q9Y2H0
QVVGLKFLTNMTITN

ARMCX2

486

Q7L311
GSIQSFKQQKGMNIS

ANO3

6

Q9BYT9
ITRNMNTNIKNGILS

RAD51AP2

551

Q09MP3
NQVLSKVAMSQPLFN

RBM20

121

Q5T481
SGLKTQRNTSINMQL

NRG3

556

P56975
GQTQKMNLFQSVTSA

BCKDHB

66

P21953
NVLQLAKEQSMSSVG

GDAP2

151

Q9NXN4
GISVANQTVEQLQKM

CASK

541

O14936
QSGLSINNVFKMSSV

FIGNL1

101

Q6PIW4
MQSVIAFATVLTQNQ

LRRC34

221

Q8IZ02
GMQLAIQAAISQAFK

LZIC

76

Q8WZA0
SIITLKNGIQNMLQF

NFU1

216

Q9UMS0
TGLNTQTQQLLMTVK

NLRP11

956

P59045
MQDNSVQVSQKVFQG

GPC4

326

O75487
ISNMKNLGTLVLSNN

LRRC39

241

Q96DD0
KVQLGVLQSMNAFFQ

ECPAS

1731

Q5VYK3
STTVNGMAANILKNN

MLH3

531

Q9UHC1
TKINGLEVQIQAFMN

DNAH8

431

Q96JB1
GDQMAQKSQSTQISQ

FCER2

76

P06734
VNAKASQAGQTALML

KANK1

1226

Q14678
HFSMQKINGTEVTQN

LRRC49

521

Q8IUZ0
MKNLSQDVNGTLVSI

LNPEP

366

Q9UIQ6
TMGLQLNITQDKVAS

LAMP2

236

P13473
QALQTFAKTSGTMNN

MICAL1

891

Q8TDZ2
MQEFANGLLNKVVTS

SLC11A1

456

P49279
LQMTKQVNNGLTLSD

FBXO25

216

Q8TCJ0
SGMVKQVALQTFGNQ

BPNT2

246

Q9NX62
QAGSILMTVNTLQGK

CCDC182

6

A6NF36
TNMQGFTKSLNAFNV

HDAC3

76

O15379
ANITFLSINMKNVLQ

IL20RA

41

Q9UHF4
KLVNMQTSGSQIQSE

ABCB4

626

P21439
GNQITMQRKSETQIS

HFM1

1101

A2PYH4
MGKTTTGQIVNLLSN

ABCC4

186

O15439
GALTLMQVSVTNQTK

MALRD1

1396

Q5VYJ5
QLILQNNIEMTTGTF

BRCA2

1291

P51587
QQVFSVQKGLNDTMR

CCNF

296

P41002
GEVVQSSNTNQMVFK

FAHD2B

241

Q6P2I3
KSVFEQSLSQQGLMN

FOXJ3

301

Q9UPW0
NLQNTATKAIIQGLM

COL14A1

76

Q05707
VSTQMSKQLSLLANG

FSTL4

381

Q6MZW2
SQGILNAMITKISNE

HAUS3

151

Q68CZ6
SQNIVLNGKTIVMND

DCTN5

31

Q9BTE1
VMGIQSGKNFINTNA

ENKUR

96

Q8TC29
SVGSVNFMKQTNIQK

ESCO2

346

Q56NI9
FFLKNALVSTLGQMQ

FBXO24

156

O75426
VKQTAQMLQSFGTEL

MCF2L

241

O15068
INAKASQAGQTALML

KANK2

731

Q63ZY3
LQQKVQNSKMSEASG

CEP57L1

391

Q8IYX8
GANIQSIMASEKQVN

EXOC1

201

Q9NV70
QQKSLMDQLQGVVSN

GRM1

1026

Q13255
QQQKRLTTGLMTQAE

FAM27D1

36

Q5T7N8
QQTQRKMLLDVTTGQ

C4orf54

1606

D6RIA3
KIQTQISSGMTNNAS

DNAH2

936

Q9P225
QIKVLNIGNNTMNIS

SLC15A1

396

P46059
MQLNLTVNSSKNFTV

RYK

171

P34925
HKITNNQTGQMVFSE

DKK3

116

Q9UBP4
FLSQMGKQSAVVLNI

C18orf63

131

Q68DL7
QESLKLMTAGNFLQN

DNAH5

3351

Q8TE73
QGVALQTMKQEFLIN

AFP

541

P02771
NNTLMSLSVGKTFQL

MAP4K5

561

Q9Y4K4
TKVASMAFQTQAGAQ

PKD1

2846

P98161
TAQLMATAQKTVVNQ

NYNRIN

596

Q9P2P1
KGAMQTGLNTTQNIA

PLIN4

401

Q96Q06
SSNQVTQAVAKLGMS

UTRN

631

P46939
AGKSSLINAIIQQAM

NUGGC

111

Q68CJ6
TNGQTVNLQAVMKDV

POLR1A

321

O95602
QSGNIQSTVMLDKQK

STAT1

126

P42224
QFSAQGLSIEQTMLK

PRUNE2

216

Q8WUY3
KTQMNSFLLSTASQQ

SMARCD1

401

Q96GM5
MENLQTNFSLVQGST

SKIL

1

P12757
VTGQVLKNSSATMNL

TAAR6

326

Q96RI8
VLTQVNQLKTSMQSV

SYNE2

5261

Q8WXH0
AKFQQLANISMSGNN

SYNE2

5406

Q8WXH0
AAAAKTQFLQNMQTA

TEDC2

236

Q7L2K0
KFLVTQMAGFLANQQ

NBPF7P

61

P0C2Y1
ALNILQSTNMAFGKV

RFC5

216

P40937
TGQQISLFQAMQKGL

EPPK1

696

P58107
GQQISLFQAMQKDLI

EPPK1

2316

P58107
TGQQISLFQAMQKDL

EPPK1

2851

P58107
TGQQISLFQAMQKDL

EPPK1

3916

P58107
GQQISLFQAMQKDLI

EPPK1

4451

P58107
KGNTAAQMAQILSFN

SERPINB6

46

P35237
VLSQSSLMGSQQFQD

SIK3

1251

Q9Y2K2
KTNFTNLLGGLQSMV

SLC25A41

126

Q8N5S1
AVRNGSMKVQISSQN

TANC1

1546

Q9C0D5
MVSQLSRGKQAFTQQ

MYH4

1301

Q9Y623
ADGTLFKVQVTSQNM

SGCB

291

Q16585
FKVQVTSQNMGCQIS

SGCB

296

Q16585
EIFSNMNIKNFTVSG

TLR1

321

Q15399
LKAQMSNFLASTTNQ

SMARCD2

416

Q92925
VGNVLVMISFKVNSQ

CHRM5

46

P08912
LAQKSGNIINMSSVA

BDH2

121

Q9BUT1
RQMSQQNLTKQTGLS

APC

2371

P25054
NIGTNFEMSVVQLAK

TGDS

256

O95455
VVMKFQFTRNNNGAS

TMPRSS11D

116

O60235
LQFDINSVGKQTGMT

FYTTD1

276

Q96QD9
KVINQMLSKAAQSGQ

TUBD1

71

Q9UJT1
NLMQSINQSKKTVFV

TLR8

931

Q9NR97
LKNQIFTGIQMQTRS

ZNF562

106

Q6V9R5
TSQKMFVNTKAVQGV

MIOS

216

Q9NXC5
LKMSATFIGNNTAIQ

TUBB8

361

Q3ZCM7
ATTQKQEQIINTMTQ

TPR

751

P12270
QNFLRTQMGNTTTVN

RYR3

3751

Q15413
MGQQISDQTQLVINK

RNF141

1

Q8WVD5
QSQGVRKNNVFMTSA

RANBP3L

86

Q86VV4
TGSIQNNMLTLNLVK

THAP5

156

Q7Z6K1
TKLISMFNQSSQTQE

UBE3D

91

Q7Z6J8
QSLNIMNSFSQKVKI

TMEM131

691

Q92545
LKMSATFIGNNAAIQ

TUBB8B

361

A6NNZ2
TKINMNGVNSSNGVV

UBE2V1

86

Q13404
FQVNQTKTNGPTMTN

PKHD1L1

861

Q86WI1
MLTALGQVNNIQKEF

PRO1716

1

Q9UHU1
QQISLFQAMQKGLIV

PLEC

2921

Q15149
KLMTTGNNTVRFNPN

UBE2Z

166

Q9H832
ISNMTFSNGKLIVNQ

TNFSF11

196

O14788
LTMSEKGFQQISFVN

TOP2A

301

P11388
EVNLSMQGKNVTVFT

ZBED5

486

Q49AG3
IQVIGNLKNISMASS

TLN2

1301

Q9Y4G6
RFVTKINMNGINNSS

UBE2V2

81

Q15819
NGLNQCLTTTQSKMF

ZNF66

131

Q6ZN08
TLIQTFQKMTVTLNF

TMEM130

251

Q8N3G9
LSFQGMIQTNIASKT

ZC3HAV1

661

Q7Z2W4
QGQSVQMSGAIKQAS

TBC1D5

686

Q92609
GKNKSIQMTNQTFST

ABI3BP

876

Q7Z7G0
IQMTNQTFSTVENLK

ABI3BP

881

Q7Z7G0
MQSINAGFQSLKTLI

TFAP4

61

Q01664
AKGTTAAQMAQVLQF

SERPINB10

46

P48595
SLKGQVLSTINTNQM

TBL2

216

Q9Y4P3
NNKGASNNVTQMIVL

TBX21

246

Q9UL17
STIGQMPNNQSINSK

TNRC6A

396

Q8NDV7
QQSKMENAGVNFVVS

TNRC6B

346

Q9UPQ9
MQLIFKGIQGSNTAS

ZAN

506

Q9Y493
EFQQIINLALQKTGM

L1TD1

101

Q5T7N2
QFGASIQQQATVMLK

GRIN2A

146

Q12879