Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin binding

MYO9A MICAL2 VASH2 DYRK1A LSP1 VPS16 NEB TNNI3

2.66e-05479518GO:0003779
GeneOntologyMolecularFunctionarmadillo repeat domain binding

STRN3 STRN

2.28e-049512GO:0070016
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat kinase activity

CDK8 DYRK1A

2.84e-0410512GO:0008353
GeneOntologyMolecularFunctionstructural constituent of ribosome

RPL36AL RPL36A MRPS22 RPL8

1.22e-03183514GO:0003735
GeneOntologyMolecularFunctionisomerase activity

FBH1 AIP FKBP5 PUS7

1.45e-03192514GO:0016853
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat modifying activity

CDK8 DYRK1A

1.56e-0323512GO:0140994
GeneOntologyMolecularFunctioncyclin-dependent protein serine/threonine kinase activity

CDK8 CDK19

2.66e-0330512GO:0004693
GeneOntologyMolecularFunctioncyclin-dependent protein kinase activity

CDK8 CDK19

2.66e-0330512GO:0097472
GeneOntologyMolecularFunctionactin filament binding

MYO9A VPS16 NEB TNNI3

2.68e-03227514GO:0051015
GeneOntologyBiologicalProcessRNA splicing

CCNL2 SRSF10 SUPT6H SF3A1 DYRK1A SNRPC THRAP3 PUS7

2.96e-05502518GO:0008380
GeneOntologyBiologicalProcessmRNA processing

SRSF10 TENT4B SUPT6H SF3A1 DYRK1A SNRPC THRAP3 PUS7

5.71e-05551518GO:0006397
GeneOntologyCellularComponentCKM complex

CDK8 CDK19

5.81e-055512GO:1990508
GeneOntologyCellularComponentactin cytoskeleton

KALRN MYO9A MICAL2 DYRK1A LSP1 VPS16 NEB TNNI3

7.09e-05576518GO:0015629
GeneOntologyCellularComponentmediator complex

CDK8 BCLAF1 THRAP3

1.00e-0437513GO:0016592
GeneOntologyCellularComponentcytosolic large ribosomal subunit

RPL36AL RPL36A RPL8

4.04e-0459513GO:0022625
GeneOntologyCellularComponentactin filament

MYO9A MICAL2 DYRK1A VPS16

4.42e-04146514GO:0005884
GeneOntologyCellularComponentcyclin-dependent protein kinase holoenzyme complex

CDK8 CCNL2 CDK19

4.46e-0461513GO:0000307
GeneOntologyCellularComponentnuclear speck

CCNL2 SRSF10 BCLAF1 SF3A1 DYRK1A THRAP3

6.10e-04431516GO:0016607
GeneOntologyCellularComponentFAR/SIN/STRIPAK complex

STRN3 STRN

7.75e-0417512GO:0090443
GeneOntologyCellularComponentnuclear cyclin-dependent protein kinase holoenzyme complex

CDK8 CDK19

8.71e-0418512GO:0019908
GeneOntologyCellularComponentU2-type prespliceosome

SF3A1 SNRPC

8.71e-0418512GO:0071004
GeneOntologyCellularComponentprespliceosome

SF3A1 SNRPC

8.71e-0418512GO:0071010
GeneOntologyCellularComponentribosomal subunit

RPL36AL RPL36A MRPS22 RPL8

1.28e-03194514GO:0044391
GeneOntologyCellularComponentstriated muscle thin filament

NEB TNNI3

1.97e-0327512GO:0005865
GeneOntologyCellularComponentribonucleoprotein complex

RPL36AL RPL36A SF3A1 DYRK1A PDCD11 SNRPC MRPS22 RPL8 FTSJ3

2.18e-031194519GO:1990904
GeneOntologyCellularComponentmyofilament

NEB TNNI3

2.76e-0332512GO:0036379
GeneOntologyCellularComponentlarge ribosomal subunit

RPL36AL RPL36A RPL8

3.00e-03118513GO:0015934
GeneOntologyCellularComponentcytosolic ribosome

RPL36AL RPL36A RPL8

3.45e-03124513GO:0022626
GeneOntologyCellularComponentribosome

RPL36AL RPL36A MRPS22 RPL8

4.06e-03267514GO:0005840
MousePhenoabnormal sarcomere morphology

KALRN CASQ1 NEB TNNI3

2.72e-0577324MP:0004090
DomainRibosomal_L44e

RPL36AL RPL36A

7.02e-062502IPR000552
DomainRibosomal_L44

RPL36AL RPL36A

7.02e-062502PF00935
DomainRibosomal_L44e

RPL36AL RPL36A

7.02e-062502PD002841
DomainRIBOSOMAL_L44E

RPL36AL RPL36A

7.02e-062502PS01172
Domain-

RPL36AL RPL36A

7.02e-0625023.10.450.80
DomainStriatin

STRN3 STRN

2.10e-053502PF08232
DomainTHRAP3_BCLAF1

BCLAF1 THRAP3

2.10e-053502IPR029199
DomainTHRAP3_BCLAF1

BCLAF1 THRAP3

2.10e-053502PF15440
DomainStriatin_N

STRN3 STRN

2.10e-053502IPR013258
DomainS1

SUPT6H PDCD11

1.95e-048502PF00575
DomainRibosomal_zn-bd

RPL36AL RPL36A

2.50e-049502IPR011332
DomainS1

SUPT6H PDCD11

3.12e-0410502PS50126
DomainZnf_C2H2_matrin

ZNF346 SNRPC

4.56e-0412502IPR000690
DomainS1

SUPT6H PDCD11

4.56e-0412502SM00316
DomainS1_dom

SUPT6H PDCD11

4.56e-0412502IPR022967
DomainS1_domain

SUPT6H PDCD11

4.56e-0412502IPR003029
DomainFKBP_PPIASE

AIP FKBP5

8.23e-0416502PS50059
DomainFKBP_C

AIP FKBP5

8.23e-0416502PF00254
DomainZF_MATRIN

ZNF346 SNRPC

1.05e-0318502PS50171
DomainPPIase_FKBP_dom

AIP FKBP5

1.29e-0320502IPR001179
DomainNA-bd_OB-fold

SUPT6H PDCD11 RPL8

1.43e-0383503IPR012340
DomainG-protein_beta_WD-40_rep

STRN3 STRN WDR31

1.53e-0385503IPR020472
DomainZnF_U1

ZNF346 SNRPC

2.72e-0329502SM00451
DomainZnf_U1

ZNF346 SNRPC

2.72e-0329502IPR003604
PathwayREACTOME_MAJOR_PATHWAY_OF_RRNA_PROCESSING_IN_THE_NUCLEOLUS_AND_CYTOSOL

RPL36AL RPL36A PDCD11 RPL8 FTSJ3

1.86e-04180425MM15324
PathwayREACTOME_METABOLISM_OF_RNA

SRSF10 RPL36AL RPL36A SF3A1 PDCD11 SNRPC RPL8 PUS7 FTSJ3

2.29e-04724429M16843
PathwayREACTOME_RRNA_PROCESSING

RPL36AL RPL36A PDCD11 RPL8 FTSJ3

3.40e-04205425M27685
PathwayREACTOME_METABOLISM_OF_RNA

SRSF10 RPL36AL RPL36A SF3A1 PDCD11 SNRPC RPL8 FTSJ3

3.84e-04612428MM15547
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

ZNF346 SRSF10 RPL36AL RPL36A BCLAF1 SF3A1 PDCD11 SNRPC THRAP3 MRPS22

4.67e-11330511033301849
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

ZNF346 SRSF10 TENT4B RPL36A SUPT6H BCLAF1 SF3A1 PDCD11 SNRPC THRAP3 RPL8 PUS7 FTSJ3

1.09e-10807511322681889
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

SRSF10 RPL36AL RPL36A BCLAF1 SCML1 SF3A1 PDCD11 SNRPC THRAP3 MRPS22 RPL8 FTSJ3

5.10e-10731511229298432
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

STRN3 STRN SRSF10 SUPT6H BCLAF1 SF3A1 DYRK1A PDCD11 SNRPC THRAP3 MRPS22

2.96e-09670511122990118
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

SRSF10 SUPT6H BCLAF1 SF3A1 AIP THRAP3 FTSJ3

4.25e-0916351722113938
Pubmed

The protein interaction landscape of the human CMGC kinase group.

CDK8 SRSF10 BCLAF1 CDK19 DYRK1A PDCD11 NEB SNRPC THRAP3 FKBP5 FTSJ3

4.32e-09695511123602568
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

ZNF346 RPL36AL RPL36A SF3A1 ZNF735 PEX1 PDCD11 SNRPC THRAP3 MRPS22 FKBP5 RPL8 FTSJ3

8.07e-091153511329845934
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

SRSF10 RPL36AL TENT4B RPL36A BCLAF1 SF3A1 PDCD11 THRAP3 MRPS22 RPL8 FTSJ3

3.28e-08847511135850772
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

SRSF10 SUPT6H BCLAF1 DYRK1A PDCD11 THRAP3 RPL8 FTSJ3

5.38e-0836151830344098
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

SRSF10 TENT4B RPL36A SUPT6H BCLAF1 SF3A1 PDCD11 URB2 THRAP3 RPL8 FTSJ3

1.57e-07989511136424410
Pubmed

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

ZNF346 SRSF10 RPL36AL RPL36A THRAP3 MRPS22 RPL8 FTSJ3

1.74e-0742151834650049
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

CCNL2 STRN3 STRN DYRK1A AIP NEB THRAP3 FKBP5

2.12e-0743251823455922
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

SRSF10 RPL36AL RPL36A SUPT6H SNRPC THRAP3 USP6NL RPL8 FTSJ3

2.50e-0761551931048545
Pubmed

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.

SRSF10 SUPT6H BCLAF1 THRAP3 MRPS22 RPL8

3.39e-0718851629721183
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

RPL36AL RPL36A SUPT6H BCLAF1 SF3A1 VPS16 SNRPC THRAP3 MRPS22 RPL8

3.60e-07847511035235311
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SRSF10 RPL36AL RPL36A KALRN SUPT6H BCLAF1 SF3A1 SNRPC THRAP3 MRPS22 RPL8

3.83e-071082511138697112
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

SRSF10 RPL36AL RPL36A BCLAF1 PDCD11 SNRPC THRAP3 MRPS22 RPL8

5.65e-0767851930209976
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

SRSF10 RPL36AL RPL36A BCLAF1 SNRPC THRAP3 MRPS22 RPL8 FTSJ3

8.58e-0771351929802200
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RPL36A SUPT6H BCLAF1 SF3A1 PDCD11 AIP USP6NL MRPS22 FKBP5 RPL8 PUS7 FTSJ3

1.20e-061487511233957083
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

STRN3 ZNF346 STRN SRSF10 RPL36AL TENT4B SUPT6H DYRK1A PDCD11 URB2 USP6NL MRPS22

1.29e-061497511231527615
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

CDK8 SRSF10 RPL36AL MICAL2 BCLAF1 SF3A1 THRAP3 MRPS22 FKBP5 RPL8 FTSJ3

1.54e-061247511127684187
Pubmed

Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.

RPL36AL RPL36A BCLAF1 THRAP3 RPL8 FTSJ3

1.59e-0624551621182205
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

STRN3 STRN RPL36A MYO9A SCML1 SF3A1 CASQ1 RPL8

1.77e-0657351828330616
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

SRSF10 RPL36AL RPL36A SUPT6H MRPS22 RPL8

1.83e-0625151628077445
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

STRN3 STRN SRSF10 RPL36A BCLAF1 SF3A1 CDK19 DYRK1A THRAP3 MRPS22 FTSJ3

2.04e-061284511117353931
Pubmed

Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo.

STRN3 STRN

2.11e-06251238718356
Pubmed

WD-40 repeat protein SG2NA has multiple splice variants with tissue restricted and growth responsive properties.

STRN3 STRN

2.11e-06251218571342
Pubmed

The Dual-Specificity Kinase DYRK1A Modulates the Levels of Cyclin L2 To Control HIV Replication in Macrophages.

CCNL2 DYRK1A

2.11e-06251231852782
Pubmed

Mediator kinase inhibition further activates super-enhancer-associated genes in AML.

CDK8 CDK19

2.11e-06251226416749
Pubmed

Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.

CDK8 CDK19

2.11e-06251232560467
Pubmed

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

CDK8 CDK19

2.11e-06251228855340
Pubmed

Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.

CDK8 CDK19

2.11e-06251235181333
Pubmed

Regulatory functions of the Mediator kinases CDK8 and CDK19.

CDK8 CDK19

2.11e-06251230585107
Pubmed

Btf and TRAP150 have distinct roles in regulating subcellular mRNA distribution.

BCLAF1 THRAP3

2.11e-06251223778535
Pubmed

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export.

BCLAF1 THRAP3

2.11e-06251229112714
Pubmed

Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.

CDK8 CDK19

2.11e-06251227678455
Pubmed

HIV Transcription Is Independent of Mediator Kinases.

CDK8 CDK19

2.11e-06251231044597
Pubmed

CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.

CDK8 CDK19

2.11e-06251236006697
Pubmed

[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].

CDK8 CDK19

2.11e-06251220408451
Pubmed

CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.

CDK8 CDK19

2.11e-06251237378433
Pubmed

Identification of target genes for the CDK subunits of the Mediator complex.

CDK8 CDK19

2.11e-06251222117896
Pubmed

Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex.

STRN3 STRN

2.11e-06251236602306
Pubmed

BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells.

SRSF10 BCLAF1

2.11e-06251225091051
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SRSF10 RPL36A SUPT6H BCLAF1 SF3A1 JAZF1 PDCD11 SNRPC THRAP3 RPL8 FTSJ3

2.20e-061294511130804502
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

SRSF10 RPL36AL RPL36A SF3A1 PDCD11 SNRPC THRAP3 MRPS22 FKBP5 RPL8 FTSJ3

2.62e-061318511130463901
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

SUPT6H BCLAF1 CDK19 PDCD11 VPS16 THRAP3

2.90e-0627251631010829
Pubmed

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.

SRSF10 BCLAF1 SF3A1 PDCD11 THRAP3 RPL8 FTSJ3

3.05e-0643051738172120
Pubmed

Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.

SRSF10 BCLAF1 PDCD11 RPL8 FTSJ3

5.45e-0617251526336360
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

SRSF10 TENT4B RPL36A SUPT6H BCLAF1 SF3A1 PDCD11 URB2 THRAP3 RPL8 FTSJ3

5.53e-061425511130948266
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CCNL2 RPL36AL RPL36A BCLAF1 SF3A1 DYRK1A PEX1 AIP THRAP3

6.27e-0691051936736316
Pubmed

Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.

CDK8 CDK19

6.32e-06351226002960
Pubmed

Novel NTRK3 Fusions in Fibrosarcomas of Adults.

STRN3 STRN

6.32e-06351230520818
Pubmed

Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein.

RPL36AL RPL36A

6.32e-0635123542712
Pubmed

Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.

CDK8 CDK19

6.32e-06351228151579
Pubmed

Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.

SUPT6H BCLAF1 SF3A1 SNRPC THRAP3

7.18e-0618251526527279
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

RPL36AL RPL36A BCLAF1 SF3A1 PDCD11 THRAP3 USP6NL RPL8 FTSJ3

8.78e-0694951936574265
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

SRSF10 RPL36A BCLAF1 SF3A1 SNRPC THRAP3 MRPS22 RPL8

8.87e-0671451828302793
Pubmed

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.

CDK8 CDK19

1.26e-05451229440396
Pubmed

Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain.

STRN3 STRN

1.26e-05451210748158
Pubmed

Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.

CDK8 CDK19

1.26e-05451232439758
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

STRN3 STRN SUPT6H VPS16 AIP

1.50e-0521251533853758
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

STRN3 STRN SF3A1 THRAP3 PUS7

1.61e-0521551535973513
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

SRSF10 SUPT6H BCLAF1 SF3A1 PDCD11 URB2 THRAP3 RPL8 FTSJ3

1.61e-05102451924711643
Pubmed

The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.

SUPT6H SF3A1 MRPS22 RPL8 FTSJ3

1.79e-0522051534091597
Pubmed

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.

CDK8 CDK19

2.10e-05551236545778
Pubmed

The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members.

STRN3 STRN

2.10e-05551218502210
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

ZNF346 SRSF10 BCLAF1 DYRK1A VPS16 THRAP3 RPL8

2.66e-0560151733658012
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

SUPT6H BCLAF1 SF3A1 PDCD11 THRAP3 RPL8 FTSJ3

2.78e-0560551728977666
Pubmed

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

SUPT6H BCLAF1 PDCD11

3.04e-05415138724849
Pubmed

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle.

AIP FKBP5

3.15e-05651221170051
Pubmed

Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.

BCLAF1 THRAP3

3.15e-05651224100041
Pubmed

WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A.

STRN3 STRN

3.15e-05651210681496
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

STRN3 STRN KALRN MYO9A MICAL2 BCLAF1 DYRK1A THRAP3 MRPS22 RPL8

3.69e-051431511037142655
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

STRN3 RPL36A SF3A1 AIP SNRPC MRPS22 FKBP5 RPL8 FTSJ3

3.96e-05114951935446349
Pubmed

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.

SRSF10 BCLAF1 THRAP3 RPL8 FTSJ3

3.99e-0526051536199071
Pubmed

Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice.

CASQ1 NEB

4.41e-05751212176734
Pubmed

Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.

CDK8 CDK19

4.41e-05751222668559
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

RPL36AL RPL36A BCLAF1 THRAP3 MRPS22 RPL8 FTSJ3

4.59e-0565551735819319
Pubmed

Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.

CDK8 CDK19

5.87e-05851223749998
Pubmed

Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I.

AIP TNNI3

5.87e-05851212721663
Pubmed

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.

CDK8 CDK19

5.87e-05851230695077
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

BCLAF1 SF3A1 THRAP3 FTSJ3

6.73e-0514851432538781
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

ZNF346 SRSF10 BCLAF1 SF3A1 PDCD11 SNRPC THRAP3 FTSJ3

6.97e-0595451836373674
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

ZNF346 STRN RPL36AL RPL36A SNRPC MRPS22 FTSJ3

7.03e-0570151730196744
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

RPL36AL RPL36A PDCD11 URB2 RPL8 FTSJ3

7.38e-0548351636912080
Pubmed

Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.

CCNL2 DYRK1A

7.54e-05951214623875
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

MYO9A BCLAF1 PDCD11 THRAP3 RPL8 FTSJ3

7.63e-0548651630940648
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

SRSF10 BCLAF1 CYP24A1 PDCD11 SNRPC THRAP3 RPL8

7.68e-0571151733022573
Pubmed

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

RPL36A SF3A1 DYRK1A RPL8 FTSJ3

7.84e-0530051528561026
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

SRSF10 TENT4B BCLAF1 SF3A1 PDCD11 THRAP3 MRPS22 RPL8 FTSJ3

7.92e-05125751936526897
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

STRN3 STRN RPL36AL TENT4B RPL36A BCLAF1 THRAP3

9.05e-0573051734857952
Pubmed

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.

BCLAF1 PDCD11 THRAP3 RPL8

9.56e-0516251431363146
Pubmed

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.

SRSF10 SF3A1 THRAP3 RPL8

1.13e-0416951423084401
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

ZNF346 TENT4B PDCD11 URB2 MRPS22 RPL8 FTSJ3

1.15e-0475951735915203
Pubmed

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.

BCLAF1 SF3A1 THRAP3 MRPS22

1.20e-0417251423184937
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

ZNF346 SRSF10 RPL36A SF3A1 PEG3 AIP MRPS22 FKBP5 RPL8

1.25e-04133551929229926
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

ZNF346 SRSF10 RPL36AL BCLAF1 SF3A1 RPL8

1.33e-0453851628524877
Pubmed

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.

CDK8 CDK19

1.38e-041251223563140
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SRSF10 MYO9A MICAL2 PDCD11 URB2 VPS16 THRAP3 RPL8 FTSJ3

1.38e-04135351929467282
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

SUPT6H PDCD11 URB2 THRAP3 FTSJ3

1.41e-0434051529478914
InteractionZBTB2 interactions

ZNF346 SRSF10 RPL36AL RPL36A BCLAF1 SF3A1 PDCD11 SNRPC THRAP3 MRPS22 PUS7

1.30e-084505111int:ZBTB2
InteractionCLK3 interactions

ZNF346 SRSF10 BCLAF1 PDCD11 AIP SNRPC THRAP3 FKBP5

7.55e-08220518int:CLK3
InteractionZC3H18 interactions

ZNF346 SRSF10 RPL36AL RPL36A BCLAF1 SCML1 SF3A1 PDCD11 SNRPC THRAP3 MRPS22 RPL8 FTSJ3

1.88e-078775113int:ZC3H18
InteractionMAGEB2 interactions

CCNL2 ZNF346 RPL36AL TENT4B RPL36A PDCD11 URB2 RPL8 FTSJ3

2.03e-07349519int:MAGEB2
InteractionCSNK2A1 interactions

CCNL2 STRN SRSF10 RPL36A IGFBP3 SUPT6H BCLAF1 SF3A1 URB2 AIP THRAP3 RPL8 FTSJ3

5.04e-079565113int:CSNK2A1
InteractionPSKH1 interactions

SCML1 PDCD11 AIP MRPS22 FKBP5

6.25e-0765515int:PSKH1
InteractionZNF48 interactions

ZNF346 TENT4B PDCD11 URB2 RPL8 FTSJ3

2.02e-06149516int:ZNF48
InteractionSRSF5 interactions

ZNF346 SRSF10 RPL36AL TENT4B SF3A1 DYRK1A MRPS22 RPL8 FTSJ3

2.58e-06474519int:SRSF5
InteractionSNRNP70 interactions

CDK8 SRSF10 RPL36AL RPL36A BCLAF1 SF3A1 DYRK1A SNRPC THRAP3 MRPS22 RPL8 FTSJ3

4.66e-069845112int:SNRNP70
InteractionTSSK6 interactions

BCLAF1 AIP THRAP3 FKBP5

5.99e-0647514int:TSSK6
InteractionRPL31 interactions

ZNF346 RPL36AL TENT4B RPL36A SUPT6H BCLAF1 PDCD11 URB2 RPL8 FTSJ3

6.55e-066805110int:RPL31
InteractionPRKRA interactions

ZNF346 RPL36AL TENT4B PDCD11 NEIL3 URB2 RPL8 FTSJ3

6.78e-06400518int:PRKRA
InteractionCBX6 interactions

ZNF346 RPL36AL TENT4B SCML1 DYRK1A RPL8 FTSJ3

6.82e-06283517int:CBX6
InteractionDHX8 interactions

ZNF346 RPL36AL BCLAF1 SNRPC THRAP3 RPL8 FTSJ3

8.37e-06292517int:DHX8
InteractionSRSF7 interactions

SRSF10 RPL36A BCLAF1 SF3A1 CDK19 DYRK1A SNRPC THRAP3

1.05e-05425518int:SRSF7
InteractionZC3H10 interactions

ZNF346 RPL36AL TENT4B PDCD11 RPL8 FTSJ3

1.10e-05200516int:ZC3H10
InteractionNIFK interactions

ZNF346 RPL36AL TENT4B CDK19 PDCD11 URB2 RPL8 FTSJ3

1.17e-05431518int:NIFK
InteractionOBSL1 interactions

SRSF10 RPL36AL SUPT6H BCLAF1 SF3A1 DYRK1A PDCD11 URB2 THRAP3 RPL8 FTSJ3

1.25e-059025111int:OBSL1
InteractionMECP2 interactions

SRSF10 RPL36AL RPL36A KALRN SUPT6H BCLAF1 SF3A1 PDCD11 URB2 SNRPC THRAP3 MRPS22 RPL8

1.34e-0512875113int:MECP2
InteractionLARP7 interactions

ZNF346 RPL36AL RPL36A SF3A1 PEX1 PDCD11 SNRPC THRAP3 MRPS22 FKBP5 RPL8 FTSJ3

1.62e-0511135112int:LARP7
InteractionTRIM31 interactions

ZNF346 SRSF10 RPL36AL RPL36A THRAP3 MRPS22 RPL8 FTSJ3

1.70e-05454518int:TRIM31
InteractionSRPK1 interactions

SRSF10 BCLAF1 DYRK1A PDCD11 URB2 SNRPC THRAP3 FTSJ3

2.42e-05477518int:SRPK1
InteractionDDX23 interactions

SRSF10 SUPT6H BCLAF1 SF3A1 PDCD11 SNRPC THRAP3 FTSJ3

2.53e-05480518int:DDX23
InteractionMYCN interactions

ZNF346 SRSF10 RPL36AL RPL36A MICAL2 BCLAF1 SF3A1 PDCD11 SNRPC THRAP3 MRPS22 RPL8 FTSJ3

2.67e-0513735113int:MYCN
InteractionSNRNP40 interactions

SRSF10 TENT4B SUPT6H BCLAF1 SF3A1 PDCD11 AIP SNRPC FTSJ3

2.76e-05637519int:SNRNP40
InteractionDOT1L interactions

SRSF10 RPL36AL TENT4B RPL36A SF3A1 PDCD11 THRAP3 MRPS22 RPL8 FTSJ3

2.88e-058075110int:DOT1L
InteractionANOS1 interactions

ZNF346 RPL36AL PDCD11 URB2 FTSJ3

3.03e-05143515int:ANOS1
InteractionCDKL2 interactions

BCLAF1 PDCD11 THRAP3 FKBP5

3.12e-0571514int:CDKL2
InteractionLUC7L interactions

SRSF10 RPL36AL BCLAF1 SNRPC THRAP3 MRPS22

3.23e-05242516int:LUC7L
InteractionAPOBEC3D interactions

SRSF10 RPL36AL AIP SNRPC THRAP3

3.57e-05148515int:APOBEC3D
InteractionDHX40 interactions

CCNL2 SUPT6H BCLAF1 PDCD11 THRAP3 FTSJ3

3.79e-05249516int:DHX40
InteractionRC3H2 interactions

SRSF10 RPL36AL RPL36A BCLAF1 PDCD11 SNRPC THRAP3 MRPS22 RPL8

3.96e-05667519int:RC3H2
InteractionMEN1 interactions

SRSF10 RPL36AL TENT4B RPL36A BCLAF1 SF3A1 PDCD11 THRAP3 MRPS22 RPL8 FTSJ3

4.23e-0510295111int:MEN1
InteractionAATF interactions

ZNF346 RPL36AL BCLAF1 PDCD11 THRAP3 RPL8 FTSJ3

4.25e-05376517int:AATF
InteractionZNF512 interactions

ZNF346 RPL36AL PDCD11 URB2 RPL8 FTSJ3

4.42e-05256516int:ZNF512
InteractionHNRNPU interactions

RPL36A BCLAF1 SF3A1 GNPTAB PDCD11 SNRPC THRAP3 MRPS22 FKBP5 RPL8 FTSJ3

4.46e-0510355111int:HNRNPU
InteractionFGFBP1 interactions

RPL36AL TENT4B PDCD11 URB2 RPL8 FTSJ3

4.52e-05257516int:FGFBP1
InteractionRRP8 interactions

ZNF346 TENT4B PDCD11 URB2 RPL8 FTSJ3

4.72e-05259516int:RRP8
InteractionMAK16 interactions

ZNF346 RPL36AL PDCD11 RPL8 FTSJ3

5.50e-05162515int:MAK16
InteractionTBCK interactions

SRSF10 BCLAF1 SNRPC THRAP3

5.50e-0582514int:TBCK
InteractionCAND1 interactions

ZNF346 SRSF10 BCLAF1 SF3A1 PDCD11 SNRPC THRAP3 MRPS22 RPL8 FTSJ3

6.85e-058945110int:CAND1
InteractionSRPK2 interactions

SRSF10 SUPT6H BCLAF1 DYRK1A PDCD11 URB2 SNRPC THRAP3 FTSJ3

6.92e-05717519int:SRPK2
InteractionRPL14 interactions

ZNF346 RPL36AL TENT4B RPL36A PDCD11 URB2 RPL8 FTSJ3

6.97e-05554518int:RPL14
InteractionHEXIM1 interactions

RPL36AL RPL36A SF3A1 ZNF735 DYRK1A SNRPC THRAP3 MRPS22 RPL8 FTSJ3

8.16e-059135110int:HEXIM1
InteractionSRSF1 interactions

SRSF10 TENT4B SF3A1 DYRK1A SNRPC THRAP3 RPL8 FTSJ3

8.50e-05570518int:SRSF1
InteractionRNPS1 interactions

CCNL2 SRSF10 SUPT6H SCML1 SF3A1 SNRPC THRAP3

9.18e-05425517int:RNPS1
InteractionRPL13A interactions

RPL36AL TENT4B FBH1 RPL36A PDCD11 URB2 RPL8 FTSJ3

1.09e-04591518int:RPL13A
InteractionSRPK3 interactions

RPL36AL PDCD11 SNRPC THRAP3 FTSJ3

1.17e-04190515int:SRPK3
InteractionUTP23 interactions

ZNF346 RPL36AL TENT4B RPL8 FTSJ3

1.20e-04191515int:UTP23
InteractionPOLR2E interactions

CDK8 SUPT6H CDK19 SNRPC FKBP5 FTSJ3

1.23e-04308516int:POLR2E
InteractionPRKACG interactions

CCNL2 AIP SNRPC FKBP5

1.24e-04101514int:PRKACG
InteractionRPL18A interactions

RPL36AL TENT4B RPL36A PDCD11 URB2 RPL8 FTSJ3

1.26e-04447517int:RPL18A
InteractionRPL5 interactions

ZNF346 RPL36AL RPL36A BCLAF1 PDCD11 AIP RPL8 FTSJ3

1.30e-04606518int:RPL5
InteractionRPA4 interactions

STRN3 STRN TENT4B BCLAF1 SF3A1 THRAP3 RPL8

1.35e-04452517int:RPA4
InteractionPRC1 interactions

SRSF10 RPL36AL BCLAF1 SF3A1 PDCD11 URB2 SNRPC THRAP3 RPL8 FTSJ3

1.38e-049735110int:PRC1
InteractionMTBP interactions

CDK8 CDK19 FKBP5

1.41e-0440513int:MTBP
InteractionRBM4 interactions

CDK8 RPL36AL TENT4B PDCD11 URB2 SNRPC

1.48e-04319516int:RBM4
InteractionCCDC137 interactions

ZNF346 RPL36AL PDCD11 RPL8 FTSJ3

1.48e-04200515int:CCDC137
InteractionNR2C2 interactions

SRSF10 RPL36AL RPL36A SF3A1 JAZF1 PDCD11 SNRPC THRAP3 MRPS22 FKBP5 RPL8 FTSJ3

1.54e-0414035112int:NR2C2
InteractionH2AB2 interactions

RPL36AL TENT4B PDCD11 FTSJ3

1.55e-04107514int:H2AB2
InteractionMED17 interactions

CDK8 TENT4B SUPT6H CDK19 PUS7

1.56e-04202515int:MED17
InteractionBARD1 interactions

SRSF10 BCLAF1 DYRK1A SNRPC THRAP3 MRPS22

1.59e-04323516int:BARD1
InteractionNPM1 interactions

RPL36AL TENT4B BCLAF1 SCML1 DYRK1A PDCD11 AIP NEB MRPS22 RPL8 FTSJ3

1.69e-0412015111int:NPM1
InteractionPRP4K interactions

ZNF346 BCLAF1 SF3A1 SNRPC THRAP3 RPL8

1.75e-04329516int:PRP4K
InteractionRBM8A interactions

RPL36AL SF3A1 SNRPC THRAP3 RPL8 PUS7 FTSJ3

1.78e-04473517int:RBM8A
InteractionTRA2A interactions

CDK8 SRSF10 SF3A1 SNRPC THRAP3 MRPS22

1.78e-04330516int:TRA2A
InteractionCCDC59 interactions

ZNF346 RPL36AL URB2 FTSJ3

1.85e-04112514int:CCDC59
InteractionFBXW7 interactions

CDK8 ZNF346 SRSF10 IGFBP3 SUPT6H BCLAF1 DYRK1A VPS16 THRAP3 FKBP5 RPL8

1.87e-0412155111int:FBXW7
InteractionSUZ12 interactions

CDK8 SRSF10 BCLAF1 SF3A1 CDK19 JAZF1 PDCD11 THRAP3

1.97e-04644518int:SUZ12
InteractionRSBN1L interactions

TENT4B DYRK1A NEIL3 RPL8

1.98e-04114514int:RSBN1L
InteractionSNRPA interactions

ZNF346 SRSF10 SUPT6H BCLAF1 SF3A1 SNRPC THRAP3

2.00e-04482517int:SNRPA
InteractionRBBP6 interactions

ZNF346 BCLAF1 SF3A1 SNRPC THRAP3

2.12e-04216515int:RBBP6
InteractionADARB1 interactions

ZNF346 RPL36AL TENT4B SF3A1 PDCD11 RPL8 FTSJ3

2.18e-04489517int:ADARB1
InteractionKIF23 interactions

SRSF10 MICAL2 BCLAF1 DYRK1A PDCD11 SNRPC THRAP3 MRPS22 RPL8 FTSJ3

2.21e-0410315110int:KIF23
InteractionWWP2 interactions

SRSF10 RPL36AL RPL36A SUPT6H SNRPC THRAP3 USP6NL RPL8 FTSJ3

2.29e-04840519int:WWP2
InteractionRPL28 interactions

RPL36AL TENT4B RPL36A PDCD11 URB2 RPL8 FTSJ3

2.32e-04494517int:RPL28
InteractionRPLP0 interactions

ZNF346 RPL36AL TENT4B RPL36A PDCD11 URB2 RPL8 FTSJ3

2.33e-04660518int:RPLP0
InteractionPURG interactions

SRSF10 RPL36AL TENT4B PDCD11 FTSJ3

2.46e-04223515int:PURG
InteractionSRSF6 interactions

SRSF10 TENT4B BCLAF1 PDCD11 THRAP3 RPL8 FTSJ3

2.59e-04503517int:SRSF6
InteractionH3C6 interactions

SUPT6H BCLAF1 SF3A1 SNRPC THRAP3

2.62e-04226515int:H3C6
InteractionZC3H3 interactions

RPL36AL TENT4B PDCD11 MRPS22 FTSJ3

2.62e-04226515int:ZC3H3
InteractionCDK12 interactions

CDK8 ZNF346 BCLAF1 SNRPC THRAP3

2.73e-04228515int:CDK12
InteractionRC3H1 interactions

SRSF10 RPL36AL RPL36A BCLAF1 PDCD11 THRAP3 MRPS22 RPL8

2.76e-04677518int:RC3H1
InteractionPYHIN1 interactions

SRSF10 RPL36AL RPL36A SUPT6H MRPS22 RPL8

2.77e-04358516int:PYHIN1
InteractionRNF2 interactions

ZNF346 SRSF10 BCLAF1 SCML1 SF3A1 PDCD11 THRAP3 MRPS22 FTSJ3

2.87e-04866519int:RNF2
InteractionSF3B2 interactions

ZNF346 TENT4B SF3A1 NEIL3 SNRPC THRAP3 FKBP5

3.06e-04517517int:SF3B2
InteractionRPS6 interactions

ZNF346 RPL36AL TENT4B RPL36A PDCD11 URB2 MRPS22 RPL8 FTSJ3

3.07e-04874519int:RPS6
InteractionRPF2 interactions

ZNF346 PDCD11 FKBP5 RPL8 FTSJ3

3.20e-04236515int:RPF2
InteractionRPL13 interactions

ZNF346 TENT4B RPL36A DYRK1A PDCD11 URB2 RPL8 FTSJ3

3.46e-04700518int:RPL13
InteractionRPS24 interactions

ZNF346 DYRK1A PDCD11 CCDC168 URB2 RPL8 FTSJ3

3.51e-04529517int:RPS24
InteractionRPL15 interactions

ZNF346 RPL36AL RPL36A PDCD11 URB2 RPL8 FTSJ3

3.55e-04530517int:RPL15
InteractionSETD2 interactions

MYO9A SF3A1 SNRPC FTSJ3

3.77e-04135514int:SETD2
InteractionMAU2 interactions

SUPT6H CDK19 PDCD11 THRAP3

3.88e-04136514int:MAU2
InteractionDNAJC12 interactions

CDK8 CDK19 FKBP5

4.06e-0457513int:DNAJC12
InteractionDDX21 interactions

RPL36AL BCLAF1 PDCD11 URB2 SNRPC THRAP3 RPL8 FTSJ3

4.10e-04718518int:DDX21
InteractionLLPH interactions

ZNF346 RPL36AL PDCD11 FTSJ3

4.21e-04139514int:LLPH
InteractionRPL3 interactions

ZNF346 RPL36AL TENT4B RPL36A PDCD11 URB2 RPL8 FTSJ3

4.25e-04722518int:RPL3
InteractionCFH interactions

MYO9A MICAL2 DYRK1A VPS16

4.33e-04140514int:CFH
InteractionMYO10 interactions

BCLAF1 DYRK1A THRAP3 RPL8

4.45e-04141514int:MYO10
InteractionPUM3 interactions

ZNF346 TENT4B PDCD11 RPL8 FTSJ3

4.48e-04254515int:PUM3
Cytoband6p21.31

SNRPC FKBP5

9.65e-04415126p21.31
Cytoband22q12.2

SF3A1 PIK3IP1

1.92e-035851222q12.2
Cytoband19q13.4

PEG3 TNNI3

3.53e-037951219q13.4
GeneFamilyL ribosomal proteins

RPL36AL RPL36A RPL8

1.09e-0451333729
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

STRN3 STRN

3.34e-0415332696
GeneFamilyFKBP prolyl isomerases

AIP FKBP5

4.85e-0418332910
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

STRN3 STRN

6.01e-04203321371
GeneFamilyCyclin dependent kinases

CDK8 CDK19

1.02e-0326332496
GeneFamilyCyclins|Mediator complex

CDK8 CDK19

1.65e-03333321061
GeneFamilyWD repeat domain containing

STRN3 STRN WDR31

1.19e-02262333362
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

RPL36AL RPL36A SCML1 RPL8 PIK3IP1

2.24e-06185515f60b39010b9210a5f18ccd113758512bd15d7eec
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP3 BCLAF1 PEG3 THRAP3 FKBP5

2.83e-06194515e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell(14)_Tcm|World / shred on Cell_type and subtype

RPL36AL RPL36A SCML1 RPL8 PIK3IP1

3.88e-062075155521742c28b99d5e3119da11bd56a33bd4243bb3
ToppCell(16)_Tfh|World / shred on Cell_type and subtype

RPL36AL RPL36A SCML1 FKBP5 PIK3IP1

3.98e-06208515aacd9b13d08debe212b5183c94378f9cc655ff55
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IGFBP3 PEG3 LSP1 TNNI3

3.81e-051655144e13fccd32029e2879e85f8966e582a46c09e4aa
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDK8 FBH1 FKBP5 PUS7

4.28e-05170514833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCellSevere-B_naive-12|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RPL36A FKBP5 RPL8 PIK3IP1

5.35e-05180514bc20e581d37cba72b71ef62df60475a0ccee9994
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGFBP3 MYO9A CYP24A1 RPL8

6.07e-051865143dae539cce15fcf2b1b32e981d7febe94c03c600
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STRN3 MYO9A CYP24A1 JAZF1

6.33e-05188514af740fa78542438fdff627ea1f74f4eee43316be
ToppCelldroplet-Lung-30m-Hematologic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RPL36AL RPL36A LSP1 RPL8

6.33e-05188514614b6b83b54bceaf213698310cbb97139bf8dce2
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RPL36A SCML1 RPL8 PIK3IP1

6.73e-05191514f398344aaa79fc93d792e241b634a6afe4aff33d
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPL36A SCML1 RPL8 PIK3IP1

6.73e-0519151411da47d96f44ba629e3299667495e7daddbbe86c
ToppCelltumor_Lung-T/NK_cells-Naive_CD4+_T|T/NK_cells / Location, Cell class and cell subclass

RPL36A FKBP5 RPL8 PIK3IP1

6.73e-051915144eecf2d7f434f3787a9bd7b572d6fde10c751c14
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RPL36A SCML1 RPL8 PIK3IP1

6.73e-05191514ffcb2c8dbcf40281b439f4b719b5b341972ffb9a
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPL36A SCML1 RPL8 PIK3IP1

6.73e-05191514ffe88d1ad676c745c76db89f766062fd365329f4
ToppCellCOVID-19_Convalescent-Lymphoid_T/NK-CD4+_T_naive|COVID-19_Convalescent / Disease group, lineage and cell class

RPL36A SCML1 RPL8 PIK3IP1

6.87e-05192514ad7207810116e73d461242e42071901b6a9f48c6
ToppCellremission-CD4+_T_naive|remission / disease stage, cell group and cell class

RPL36A SCML1 RPL8 PIK3IP1

6.87e-05192514d96b2122e28c735d8002ad6eb2d3d52c8e9ccf2b
ToppCellCOVID-19_Convalescent-CD4+_T_naive|COVID-19_Convalescent / Disease condition and Cell class

RPL36A SCML1 RPL8 PIK3IP1

7.01e-05193514346caaf288217acaf232060629ce964a07f63432
ToppCellnormal_Lung-T/NK_cells-Naive_CD4+_T|T/NK_cells / Location, Cell class and cell subclass

RPL36A SCML1 RPL8 PIK3IP1

7.01e-051935148f8c4a45fe3eb13717501f6dad59bcb43a959b85
ToppCellnormal_Lymph_Node-T/NK_cells-Naive_CD4+_T|T/NK_cells / Location, Cell class and cell subclass

RPL36A SCML1 RPL8 PIK3IP1

7.15e-051945148a6b2405944b0bea52c5e81083a977e52731b347
ToppCellPBMC|World / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPL36AL RPL36A LSP1 RPL8

7.29e-05195514211eba45a502b961873ca2d4642f7852e6e89d7a
ToppCellPBMC|World / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPL36AL RPL36A LSP1 RPL8

7.29e-051955148cd7667a65d77dd7b301090a9b65aba254741375
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RPL36A PEG3 LSP1 RPL8

7.29e-05195514def0a3fb36eec6fbb08e1323baf2b22b28bf751a
ToppCell(0)_Normal/No_Treatment-(0)_LMPP_(LSK_cells)|World / Stress and Cell class

RPL36A LSP1 RPL8 PIK3IP1

7.44e-0519651416a23ef14c6e054634873298a320c23ea0444780
ToppCellnormal_Pleural_Fluid|World / Location, Cell class and cell subclass

RPL36AL RPL36A LSP1 PIK3IP1

7.44e-051965147029c9f4a826f6cfdcb5f7a472fba94e8945a771
ToppCellmetastatic_Lymph_Node-T/NK_cells-Naive_CD4+_T|T/NK_cells / Location, Cell class and cell subclass

RPL36A SCML1 RPL8 PIK3IP1

7.44e-051965149cc517373ce4374140ab153edc87ec5517ee1f63
ToppCellControl-CD4+_T_naive|Control / Disease condition and Cell class

RPL36A SCML1 RPL8 PIK3IP1

7.44e-0519651410455dd24d4a4466eeecb22949b83085e8333ad2
ToppCellIIF-Lymphocyte-T_NK-CD4_Naive|IIF / Disease, Lineage and Cell Type

RPL36AL RPL36A RPL8 PIK3IP1

7.58e-051975148fb7afe64caf46dd6cf0a5ed859b86b79e3595c5
ToppCelllymphoid-T_cell-CD4+_Naive_T_cell|lymphoid / Lineage, cell class and subclass

RPL36AL RPL36A RPL8 PIK3IP1

7.58e-05197514d965cf45e6a6528bb405ee04f20876a8403c8df8
ToppCellCOVID-19_Mild-CD4+_T_naive|COVID-19_Mild / Disease condition and Cell class

RPL36A SCML1 RPL8 PIK3IP1

7.58e-051975143aea21819cbedb3bcdb74ae2e7f963a44b53ed52
ToppCell(0)_Normal/No_Treatment-(0)_LMPP_(LSK_cells)|(0)_Normal/No_Treatment / Stress and Cell class

RPL36A LSP1 RPL8 PIK3IP1

7.58e-0519751423d069be60e6aa49858906283e384bb3284791b6
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-T_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL36AL FKBP5 RPL8 PIK3IP1

7.58e-05197514076fc05b32200e0a8a1e35d03c295111468d92a9
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL36AL RPL36A RPL8 PIK3IP1

7.73e-051985145024d43b4cf7dea305ed911f1e123ca7fd44e990
ToppCellCOVID-19-Heart-Mito_CM|Heart / Disease (COVID-19 only), tissue and cell type

CASQ1 NEB TNNI3 RPL8

7.73e-05198514b6cd439863d17209b86dc50ae51282dc1725955d
ToppCellMS-IIF-Lymphocyte-T/NK-Treg|IIF / Disease, condition lineage and cell class

RPL36A KALRN RPL8 PIK3IP1

7.73e-051985147bbf8403ecf9f8e403b04f18d265ece977cc49e7
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL36AL RPL36A IGFBP3 MICAL2

7.89e-051995141b74f6fbf2628f335ba5eb49b679d2f72068bbbe
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-T_lymphocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL36AL RPL36A RPL8 PIK3IP1

7.89e-05199514714f7266733becf885226fe83cf29daa91412360
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL36AL RPL36A RPL8 PIK3IP1

7.89e-0519951455a53949fac7534aa83cfc845131e02032eec5f7
ToppCellT_cells-CCR7+_T_cells|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

SCML1 FKBP5 RPL8 PIK3IP1

7.89e-05199514467820d6abe3024d9d655b9672c2f9cdc1303db3
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_T_cell|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL36AL RPL36A RPL8 PIK3IP1

7.89e-05199514551f4f4364a711efe133d38e29cd43c78bffaaa1
ToppCellMS-IIF-Lymphocyte-T/NK-CD4+_Tem|IIF / Disease, condition lineage and cell class

RPL36AL RPL36A RPL8 PIK3IP1

7.89e-05199514a876d53a9cc5d1584bed5ff679be8f5273daad37
ToppCellParenchymal|World / Cell types per location group and 10X technology with lineage, and cell group designations

RPL36AL RPL36A MICAL2 RPL8

7.89e-05199514cce684df78421b814083aed16c4cbbac5f287bbc
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL36AL RPL36A IGFBP3 MICAL2

7.89e-05199514a660f7373fca03929234cbd936735f97883fb689
ToppCellTCGA-Stomach-Primary_Tumor|TCGA-Stomach / Sample_Type by Project: Shred V9

SRSF10 PDCD11 URB2 PUS7

7.89e-0519951438f1f612b29feb868322999ceeda78e52447ec4f
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma|TCGA-Stomach / Sample_Type by Project: Shred V9

SRSF10 PDCD11 URB2 PUS7

7.89e-05199514b10698aee2e6c17bc559eb4f723024141f914b90
ToppCellMS-Multiple_Sclerosis-Lymphocyte-T/NK-CD4+_Tem|Multiple_Sclerosis / Disease, condition lineage and cell class

RPL36AL RPL36A IGFBP3 RPL8

7.89e-0519951479145d931a250c69a643936fea147e2bd50b4d6d
ToppCellVE-CD4|VE / Condition, Cell_class and T cell subcluster

RPL36AL RPL36A RPL8 PIK3IP1

8.04e-05200514f3b778b1f20c2b1e6d623df776e470a57cb1a842
ToppCellmLN|World / shred on region, Cell_type, and subtype

RPL36A SCML1 RPL8 PIK3IP1

8.04e-052005149c1617dfde9d9aaa260bbad45b7d0b9caa41e15f
ToppCellMS-IIF-Lymphocyte-T/NK-CD4+_T_naive|IIF / Disease, condition lineage and cell class

RPL36AL RPL36A RPL8 PIK3IP1

8.04e-05200514fccc4244a87b3e85e8d53285987710aeeb500415
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL36AL RPL36A RPL8 PIK3IP1

8.04e-05200514b340b6acf675c75adffb98e560080f966571f594
ToppCellCOVID-19-COVID-19_Convalescent-Lymphocyte-T/NK-CD4+_T_naive|COVID-19_Convalescent / Disease, condition lineage and cell class

RPL36A SCML1 RPL8 PIK3IP1

8.04e-05200514729873094526b7752b91470f4a7281af7d57dbf9
ToppCellmLN|World / Region, Cell class and subclass

RPL36A SCML1 RPL8 PIK3IP1

8.04e-05200514d8f76374a61db45a689ad2c338d35609629a3199
ToppCellMS-IIF-Lymphocyte-T/NK-CD8+_Tcm|IIF / Disease, condition lineage and cell class

RPL36AL RPL36A RPL8 PIK3IP1

8.04e-0520051401554c0b7b8d7a12d99853fe057a20ed775ee5b2
ToppCellMS-IIF-Lymphocyte-T/NK|IIF / Disease, condition lineage and cell class

RPL36AL RPL36A RPL8 PIK3IP1

8.04e-05200514403e956d5a770811298694081b55e47e4ca2d814
ToppCellIIF-Lymphocyte-T_NK|IIF / Disease, Lineage and Cell Type

RPL36AL RPL36A RPL8 PIK3IP1

8.04e-0520051450f2ae32e8792e2292e0113b7b27450b8dc33080
DrugTheophylline monohydrate [5967-84-0]; Up 200; 20.2uM; HL60; HT_HG-U133A

STRN3 STRN MICAL2 CDK19 USP6NL PIK3IP1

5.21e-061985162986_UP
DrugIocetamic acid [16034-77-8]; Up 200; 6.6uM; HL60; HT_HG-U133A

STRN3 TMEM53 KALRN MICAL2 PEG3 PIK3IP1

5.21e-061985163022_UP
Diseasedevelopmental and epileptic encephalopathy 87 (implicated_via_orthology)

CDK8 CDK19

2.38e-062462DOID:0112221 (implicated_via_orthology)
DiseaseAbnormal behavior

CDK8 PUS7

2.81e-0416462C0233514
Diseaseserum gamma-glutamyl transferase measurement

STRN KALRN MYO9A DYRK1A JAZF1 USP6NL FKBP5

4.99e-04914467EFO_0004532
Diseasealpha fetoprotein measurement

ZNF346 DYRK1A JAZF1

5.16e-04100463EFO_0010583
DiseaseDown syndrome (is_marker_for)

IGFBP3 DYRK1A

5.38e-0422462DOID:14250 (is_marker_for)
Diseaseosteoarthritis, hip, body mass index

JAZF1 FKBP5

1.01e-0330462EFO_0004340, EFO_1000786
Diseasestroke

KALRN MICAL2 DYRK1A

1.48e-03144463EFO_0000712

Protein segments in the cluster

PeptideGeneStartEntry
NDYLKYHKAKHEGEK

URB2

1506

Q14146
TYGHVYKARRKDGKD

CDK19

31

Q9BWU1
DSSHKKERKVYNDGY

DYRK1A

126

Q13627
YDDNVKAYFKRGKAH

AIP

261

O00170
NQYYHGKKRKHKRDA

TENT4B

551

Q8NDF8
DKVYVHYKGKLSNGK

FKBP5

51

Q13451
RKAGLALSKHYKVYK

NEIL3

236

Q8TAT5
IHKAYKDKNKYRFEI

GNPTAB

1101

Q3T906
KKRYKNVNGIKYHAK

JAZF1

181

Q86VZ6
IKDSSGHTKYVYKNK

KALRN

1511

O60229
GYSYKRGKDLKEQHD

PIK3IP1

191

Q96FE7
HKVTQYKKGKDSLYA

RPL36AL

21

Q969Q0
KAGRAYHKYKAKRNC

RPL8

181

P62917
EYQKARAKKKYIEHR

PEG3

931

Q9GZU2
YGHIGRKYQSKKKLN

FBH1

516

Q8NFZ0
KQHDTLVEYHKKYGK

CYP24A1

81

Q07973
GKYKKKSHYYRDQRR

CCNL2

481

Q96S94
KEYKSYKDDSKHKRE

BCLAF1

731

Q9NYF8
KLIGYFKSKDSEHYK

CASQ1

181

P31415
KRYKFVATGHGKYEK

LSP1

316

P33241
HSKGKRDRKKRVYDY

CCDC168

6966

Q8NDH2
YYNKRILHKTKGKRF

ETV3L

101

Q6ZN32
TYGHVYKAKRKDGKD

CDK8

31

P49336
KADAEYKKLHSYGRD

PEX1

191

O43933
WYKLDKRGSHKEYKR

MICAL2

66

O94851
KKGHAKDSQRYKVDY

IGFBP3

176

P17936
HHKTYEDIDKRGKYD

MRPS22

246

P82650
KQERAKYHKLKYGTE

STRN3

126

Q13033
HKRYGYKKHSYRLVK

SCML1

101

Q9UN30
EYALKQERAKYHKLK

STRN

106

O43815
SGRKHKENVKDYYQK

SNRPC

26

P09234
KKYLDQEKEDGKYHK

MITD1

76

Q8WV92
HKVTQYKKGKDSLYA

RPL36A

21

P83881
EGKKYIVAYHAAGKK

PUS7

226

Q96PZ0
YKKAGLGKEKRHVTY

FTSJ3

786

Q8IY81
HAYYRHKVSEFKEGK

SF3A1

91

Q15459
TKKGRKDVDEAHYAY

SUPT6H

621

Q7KZ85
KRYLDYEKQHGTEKD

PDCD11

1836

Q14690
KYKNTEKFHRRIYKG

USP6NL

86

Q92738
KSKKYYLHDDREGEG

THRAP3

876

Q9Y2W1
NARYTGKKHLKCKKY

ZNF735

176

P0CB33
HTGEKAYKRREYGKS

ZNF549

241

Q6P9A3
HYKSGSRYEKESRKK

SRSF10

216

O75494
QHNKYEAKKYASRVG

VPS16

766

Q9H269
CKDKNLAKYSAIYHK

TMEM53

46

Q6P2H8
DFEDSYKKYLHTVKK

VASH2

231

Q86V25
YRAYATEPHAKKKSK

TNNI3

26

P19429
HYQSKKHANKVKRYL

ZNF346

91

Q9UL40
KQQSKLKHSTYKYGR

WDR31

26

Q8NA23
KHYAGKVKYGVKDFR

MYO9A

651

B2RTY4
KYKEAYEKSKGKHVG

NEB

1331

P20929
REYKKGYEKSKTSFH

NEB

1856

P20929
KAKKATEYASDQKYR

NEB

2191

P20929
RLYKEDYHKTKAKIN

NEB

4286

P20929
SELKYKETYEKQKGH

NEB

4491

P20929
KETYEKQKGHYLAGK

NEB

4496

P20929
YKETFQKTKGKYHTV

NEB

5266

P20929
KYKDHVKKHLAQGSY

NEB

5651

P20929