Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

8.70e-09111465GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

3.70e-08141465GO:0003964
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-18 ERVK-25

2.66e-07371466GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-18 ERVK-25

3.14e-07381466GO:0070001
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

3.61e-07211465GO:0035613
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1B CACNA1C CACNA1D CACNA1F

2.59e-06141464GO:0008331
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

7.04e-06371465GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

8.06e-06381465GO:0034061
GeneOntologyMolecularFunctionretinoic acid-responsive element binding

RXRA RXRB RXRG

1.31e-0571463GO:0044323
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

2.10e-05461465GO:0016893
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1B CACNA1C CACNA1D CACNA1F CATSPER2

2.10e-05461465GO:0005245
GeneOntologyMolecularFunctionnuclear steroid receptor activity

PDE3A RXRA RXRB RXRG

3.08e-05251464GO:0003707
GeneOntologyMolecularFunctioncalcium channel activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F CATSPER2

4.59e-051291467GO:0005262
GeneOntologyMolecularFunctiontransporter activity

SLC24A5 TRPM6 PITPNM2 CACNA1B CACNA1C CACNA1D CACNA1F ABCA2 NOX5 CFTR FLVCR2 SLC5A1 SLC6A2 CLCN5 CATSPER2 ABCA5 SCN10A SLC4A10 TMEM184C ATG9A SLC26A11 MFSD1 LMBRD1

6.14e-05128914623GO:0005215
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F CATSPER2

1.24e-041511467GO:0015085
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-6 SMARCAL1 ERVK-7 ERVK-10 CRY2 FBH1 ERVK-8 MBD4 ERVK-11

1.36e-042621469GO:0140097
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F NOX5 CFTR CLCN5 CATSPER2 SCN10A SLC26A11

1.44e-0445914612GO:0005216
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

2.85e-04791465GO:0004521
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1B CACNA1C CACNA1D CACNA1F CLCN5 CATSPER2 SCN10A

3.89e-041821467GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1B CACNA1C CACNA1D CACNA1F CLCN5 CATSPER2 SCN10A

4.16e-041841467GO:0022832
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F NOX5 CFTR SLC5A1 SLC6A2 CLCN5 CATSPER2 SCN10A SLC4A10 SLC26A11

4.49e-0475814615GO:0015318
GeneOntologyMolecularFunctionchannel activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F NOX5 CFTR CLCN5 CATSPER2 SCN10A SLC26A11

4.88e-0452514612GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F NOX5 CFTR CLCN5 CATSPER2 SCN10A SLC26A11

4.96e-0452614612GO:0022803
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 MBD4 ERVK-11

4.97e-041361466GO:0004519
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential

CACNA1C CACNA1D

5.23e-0451462GO:0086007
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F SLC5A1 SLC6A2 CATSPER2 SCN10A SLC4A10

6.33e-0446514611GO:0046873
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F NOX5 CFTR SLC5A1 SLC6A2 CLCN5 CATSPER2 SCN10A SLC4A10 SLC26A11

7.15e-0479314615GO:0015075
GeneOntologyMolecularFunctioncullin family protein binding

DCUN1D1 DCUN1D2 DCUN1D3

8.80e-04261463GO:0097602
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 ERVK-7 ERVK-10 SIRT4 ERVK-8 ERVK-11

8.91e-041521466GO:0016779
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F NOX5 CATSPER2 SCN10A

9.65e-043431469GO:0005261
GeneOntologyMolecularFunctionnuclear receptor activity

PDE3A RXRA RXRB RXRG

9.73e-04601464GO:0004879
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F ABCA2 NOX5 CFTR FLVCR2 SLC5A1 SLC6A2 CLCN5 CATSPER2 ABCA5 SCN10A SLC4A10 SLC26A11 MFSD1

9.94e-04118014619GO:0022857
GeneOntologyMolecularFunctionligand-activated transcription factor activity

PDE3A RXRA RXRB RXRG

1.04e-03611464GO:0098531
GeneOntologyMolecularFunctioncAMP-dependent protein kinase activity

PRKX PRKY

1.09e-0371462GO:0004691
GeneOntologyMolecularFunctionglycosyltransferase activity

GALNT14 ST3GAL2 SIRT4 GXYLT2 UGT2A3 ALG10 UGT2A1 ST6GALNAC4

1.29e-032881468GO:0016757
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

CFTR SLC4A10 SLC26A11

1.63e-03321463GO:0015106
GeneOntologyMolecularFunctioncyclic nucleotide-dependent protein kinase activity

PRKX PRKY

1.85e-0391462GO:0004690
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1B CACNA1D

1.85e-0391462GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1B CACNA1D

1.85e-0391462GO:0099626
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F NOX5 SLC5A1 SLC6A2 CATSPER2 SCN10A SLC4A10

2.23e-0362714612GO:0022890
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

CFTR SLC6A2 CLCN5 SLC4A10 SLC26A11

2.27e-031251465GO:0015108
GeneOntologyMolecularFunctionubiquitin conjugating enzyme binding

DCUN1D1 DCUN1D2 DCUN1D3

2.29e-03361463GO:0031624
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC24A5 ABCA2 CFTR SLC5A1 SLC6A2 CLCN5 ABCA5 SLC4A10 SLC26A11 MFSD1

2.71e-0347714610GO:0022804
GeneOntologyMolecularFunctiongated channel activity

CACNA1B CACNA1C CACNA1D CACNA1F CFTR CLCN5 CATSPER2 SCN10A

3.23e-033341468GO:0022836
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

3.26e-031361465GO:0004540
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC24A5 TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F NOX5 SLC5A1 SLC6A2 CATSPER2 SCN10A SLC4A10

3.54e-0366414612GO:0008324
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme binding

DCUN1D1 DCUN1D2 DCUN1D3

3.57e-03421463GO:0044390
GeneOntologyMolecularFunctionchloride:bicarbonate antiporter activity

SLC4A10 SLC26A11

3.93e-03131462GO:0140900
GeneOntologyMolecularFunctionbicarbonate:monoatomic anion antiporter activity

SLC4A10 SLC26A11

3.93e-03131462GO:0140829
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

2.04e-08131465GO:0015074
GeneOntologyBiologicalProcesspositive regulation of protein neddylation

DCUN1D1 DCUN1D2 DCUN1D3

3.44e-0651463GO:2000436
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11

2.22e-05481465GO:0000731
GeneOntologyBiologicalProcessprotein neddylation

DCUN1D1 DCUN1D2 NAE1 DCUN1D3

4.99e-05291464GO:0045116
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1B CACNA1C CACNA1D CACNA1F CATSPER2

1.75e-05461475GO:0005891
GeneOntologyCellularComponentendoplasmic reticulum membrane

CYP1A2 MIA3 STBD1 RHBDF1 NOX5 CYP19A1 CFTR EI24 RDH12 SMPD4 TLR7 ERMP1 FLVCR2 ATL1 TMEM203 BCAP29 CANT1 DHCR24 ALG10 UGT2A1 PIGW ATG9A LMBRD1

3.57e-05129314723GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

CYP1A2 MIA3 STBD1 RHBDF1 NOX5 CYP19A1 CFTR EI24 RDH12 SMPD4 TLR7 ERMP1 FLVCR2 ATL1 TMEM203 BCAP29 CANT1 DHCR24 ALG10 UGT2A1 PIGW ATG9A LMBRD1

3.83e-05129914723GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

CYP1A2 MIA3 STBD1 RHBDF1 NOX5 CYP19A1 CFTR EI24 RDH12 SMPD4 TLR7 ERMP1 FLVCR2 ATL1 TMEM203 BCAP29 CANT1 DHCR24 ALG10 UGT2A1 PIGW ATG9A LMBRD1

5.32e-05132714723GO:0042175
GeneOntologyCellularComponentcalcium channel complex

CACNA1B CACNA1C CACNA1D CACNA1F CATSPER2

1.64e-04731475GO:0034704
GeneOntologyCellularComponentvacuolar membrane

ABCA2 CFTR TLR7 TMEM203 CLCN5 ABCA5 RPTOR DEPDC5 ATG9A SLC26A11 MFSD1 LMBRD1

2.52e-0450714712GO:0005774
GeneOntologyCellularComponentlysosomal membrane

ABCA2 CFTR TLR7 TMEM203 CLCN5 ABCA5 RPTOR DEPDC5 SLC26A11 MFSD1 LMBRD1

4.36e-0446214711GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

ABCA2 CFTR TLR7 TMEM203 CLCN5 ABCA5 RPTOR DEPDC5 SLC26A11 MFSD1 LMBRD1

4.36e-0446214711GO:0098852
GeneOntologyCellularComponentaxonemal central apparatus

SPAG16 HYDIN

7.23e-0461472GO:1990716
GeneOntologyCellularComponentneuronal cell body

CACNA1B CACNA1C CACNA1D CACNA1F CYP19A1 CFTR SYAP1 TIAM2 SLC6A2 RPTOR SLC4A10 PAM CCR1 TANC1 MUL1

8.16e-0483514715GO:0043025
GeneOntologyCellularComponentcell body

PITPNM2 CACNA1B CACNA1C CACNA1D CACNA1F CYP19A1 CFTR SYAP1 TIAM2 SLC6A2 RPTOR SLC4A10 PAM CCR1 TANC1 MUL1

8.54e-0492914716GO:0044297
GeneOntologyCellularComponentperikaryon

CACNA1C CACNA1D CACNA1F SYAP1 TIAM2 SLC4A10 PAM

1.03e-032231477GO:0043204
GeneOntologyCellularComponentvacuole

ABCA2 RAMP2 CFTR TLR7 TBC1D17 TMEM203 CLCN5 ABCA5 RPTOR C3 DEPDC5 ATG9A SLC26A11 MFSD1 LMBRD1

1.97e-0391314715GO:0005773
DomainCa_chan_IQ

CACNA1B CACNA1C CACNA1D CACNA1F

1.04e-0771404SM01062
DomainCa_chan_IQ

CACNA1B CACNA1C CACNA1D CACNA1F

1.04e-0771404PF08763
DomainVDCC_a1su_IQ

CACNA1B CACNA1C CACNA1D CACNA1F

1.04e-0771404IPR014873
DomainGPHH

CACNA1B CACNA1C CACNA1D CACNA1F

1.04e-0771404PF16905
DomainGPHH_dom

CACNA1B CACNA1C CACNA1D CACNA1F

1.04e-0771404IPR031649
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

4.12e-0731403IPR031688
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

4.12e-0731403PF16885
DomainVDCCAlpha1

CACNA1B CACNA1C CACNA1D CACNA1F

6.13e-07101404IPR002077
DomainVDCC_L_a1su

CACNA1C CACNA1D CACNA1F

1.64e-0641403IPR005446
DomainDCN-prot

DCUN1D1 DCUN1D2 DCUN1D3

4.08e-0651403IPR014764
DomainPONY_dom

DCUN1D1 DCUN1D2 DCUN1D3

4.08e-0651403IPR005176
DomainDCUN1

DCUN1D1 DCUN1D2 DCUN1D3

4.08e-0651403PS51229
DomainCullin_binding

DCUN1D1 DCUN1D2 DCUN1D3

4.08e-0651403PF03556
DomainChannel_four-helix_dom

CACNA1B CACNA1C CACNA1D CACNA1F CATSPER2 SCN10A

4.22e-06571406IPR027359
Domain-

CACNA1B CACNA1C CACNA1D CACNA1F CATSPER2 SCN10A

4.22e-065714061.20.120.350
DomainIon_trans_dom

TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F CATSPER2 SCN10A

2.41e-051141407IPR005821
DomainIon_trans

TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F CATSPER2 SCN10A

2.41e-051141407PF00520
DomainRetinoid-X_rcpt/HNF4

RXRA RXRB RXRG

4.76e-05101403IPR000003
DomainDNA_helicase_UvrD/REP

TRANK1 FBH1

5.58e-0521402IPR000212
DomainNuc_recep-AF1

RXRA RXRG

5.58e-0521402PF11825
DomainNuc_recep-AF1

RXRA RXRG

5.58e-0521402IPR021780
DomainLMBR1

LMBRD2 LMBRD1

3.31e-0441402PF04791
DomainLMBR1-like_membr_prot

LMBRD2 LMBRD1

3.31e-0441402IPR006876
DomainMacrogloblnA2_thiol-ester-bond

CPAMD8 C3

1.52e-0381402IPR019565
DomainThiol-ester_cl

CPAMD8 C3

1.52e-0381402PF10569
DomainMacrogloblnA2_CS

CPAMD8 C3

1.52e-0381402IPR019742
DomainA2M_N_2

CPAMD8 C3

1.52e-0381402SM01359
Domain-

CPAMD8 C3

1.52e-03814022.60.40.690
DomainA2M_recep

CPAMD8 C3

1.52e-0381402SM01361
DomainA2M

CPAMD8 C3

1.52e-0381402SM01360
Domain7TM_GPCR_Srsx

GPR15 HTR1E OR56B1 CCR1 OR56A1

1.56e-031121405SM01381
DomainA2M

CPAMD8 C3

2.41e-03101402PF00207
DomainA2M_N_2

CPAMD8 C3

2.41e-03101402IPR011625
DomainA2M_comp

CPAMD8 C3

2.41e-03101402IPR011626
DomainA2M_recep

CPAMD8 C3

2.41e-03101402PF07677
DomainA2M_comp

CPAMD8 C3

2.41e-03101402PF07678
DomainA2M_N

CPAMD8 C3

2.41e-03101402PF01835
DomainA2M_N

CPAMD8 C3

2.41e-03101402IPR002890
DomainA-macroglobulin_rcpt-bd

CPAMD8 C3

2.41e-03101402IPR009048
DomainALPHA_2_MACROGLOBULIN

CPAMD8 C3

2.41e-03101402PS00477
DomainA2M_N_2

CPAMD8 C3

2.41e-03101402PF07703
DomainMacroglobln_a2

CPAMD8 C3

2.41e-03101402IPR001599
DomainABC_A

ABCA2 ABCA5

3.51e-03121402IPR026082
Domain-

CPAMD8 C3

3.51e-031214021.50.10.20
DomainABC_transporter_CS

ABCA2 CFTR ABCA5

3.82e-03421403IPR017871
DomainZnf_hrmn_rcpt

RXRA RXRB RXRG

4.94e-03461403IPR001628
DomainNUCLEAR_REC_DBD_2

RXRA RXRB RXRG

4.94e-03461403PS51030
DomainNUCLEAR_REC_DBD_1

RXRA RXRB RXRG

4.94e-03461403PS00031
DomainZnF_C4

RXRA RXRB RXRG

4.94e-03461403SM00399
Domainzf-C4

RXRA RXRB RXRG

4.94e-03461403PF00105
DomainNuclear_hrmn_rcpt

RXRA RXRB RXRG

4.94e-03461403IPR001723
Domain-

RXRA RXRB RXRG

5.25e-034714031.10.565.10
DomainABC_tran

ABCA2 CFTR ABCA5

5.57e-03481403PF00005
DomainNucl_hrmn_rcpt_lig-bd

RXRA RXRB RXRG

5.57e-03481403IPR000536
DomainHOLI

RXRA RXRB RXRG

5.57e-03481403SM00430
DomainHormone_recep

RXRA RXRB RXRG

5.57e-03481403PF00104
DomainABC_TRANSPORTER_2

ABCA2 CFTR ABCA5

5.57e-03481403PS50893
DomainTBC

TBC1D17 TBC1D13 TBC1D22A

5.90e-03491403SM00164
DomainABC_TRANSPORTER_1

ABCA2 CFTR ABCA5

5.90e-03491403PS00211
DomainABC_transporter-like

ABCA2 CFTR ABCA5

6.25e-03501403IPR003439
DomainRabGAP-TBC

TBC1D17 TBC1D13 TBC1D22A

7.35e-03531403PF00566
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1B CACNA1C CACNA1D CACNA1F

3.68e-0861014M47762
PathwayKEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION

RXRA RXRB RXRG

3.53e-0651013M49023
PathwayWP_VITAMIN_A1_AND_A5X_PATHWAYS

RXRA RXRB RXRG

7.03e-0661013M48097
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1B CACNA1C CACNA1D CACNA1F

1.98e-05231014M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1B CACNA1C CACNA1D CACNA1F

2.80e-05251014M47948
PathwayKEGG_MEDICUS_REFERENCE_THYROID_HORMONE_SIGNALING_PATHWAY

RXRA RXRB RXRG

2.91e-0591013M47629
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

CACNA1C CACNA1D CACNA1F

1.23e-04141013M47692
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

CACNA1C CACNA1D CACNA1F RAMP2 PTGIR PRKX

1.75e-041151016M9387
PathwayWP_VITAMIN_A_AND_CAROTENOID_METABOLISM

RDH12 RXRA RXRB RXRG

2.47e-04431014M39554
PathwayWP_RETINOL_METABOLISM

RDH12 RXRA RXRB RXRG

2.70e-04441014MM15851
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_LIMIT_CHOLESTEROL_UPTAKE

RXRA RXRB

5.01e-0451012M29791
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_TRIGLYCERIDE_LIPOLYSIS_IN_ADIPOSE

RXRA RXRB

5.01e-0451012M29792
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_GLUCONEOGENESIS

RXRA RXRB

5.01e-0451012M29812
Pubmed

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.

RXRA RXRB RXRG

7.71e-083149311053444
Pubmed

Retinoid X receptors: X-ploring their (patho)physiological functions.

RXRA RXRB RXRG

7.71e-083149315608692
Pubmed

Retinoid receptors trigger neuritogenesis in retinal degenerations.

RXRA RXRB RXRG

7.71e-083149321940995
Pubmed

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.

RXRA RXRB RXRG

7.71e-08314938799145
Pubmed

Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.

RXRA RXRB RXRG

7.71e-08314937831303
Pubmed

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

RXRA RXRB RXRG

7.71e-08314931312497
Pubmed

Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.

RXRA RXRB RXRG

7.71e-08314937980510
Pubmed

Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.

RXRA RXRB RXRG

7.71e-083149312514092
Pubmed

Chromosomal localization of the human retinoid X receptors.

RXRA RXRB RXRG

7.71e-08314938034312
Pubmed

The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.

RXRA RXRB RXRG

7.71e-083149311839661
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-18 ERVK-25 ERVK-11

1.72e-0794149721542922
Pubmed

Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.

RXRA RXRB RXRG

3.07e-074149310079186
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1C CACNA1D CACNA1F

3.07e-074149320937870
Pubmed

Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.

RXRA RXRB RXRG

3.07e-07414931310259
Pubmed

Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.

RXRA RXRB RXRG

3.07e-074149326355550
Pubmed

Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.

RXRA RXRB RXRG

3.07e-074149319686701
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10

3.07e-074149310469592
Pubmed

Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.

RXRA RXRB RXRG

3.07e-07414939804293
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1B CACNA1C CACNA1D CACNA1F

4.26e-0715149420188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1B CACNA1C CACNA1D CACNA1F

4.26e-0715149424453333
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PITPNM2 ABCA2 KIF16B SMPD4 FASTKD2 ERMP1 TIAM2 TRANK1 USP38 ABCA5 RPTOR DHCR24 DEPDC5

5.13e-075291491314621295
Pubmed

Developmental expression of murine retinoid X receptor (RXR) genes.

RXRA RXRB RXRG

7.66e-07514938199055
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-18

7.66e-075149312629516
Pubmed

Retinoic acid signaling is necessary for the development of the organ of Corti.

RXRA RXRB RXRG

7.66e-075149310452855
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1B CACNA1C CACNA1D

7.66e-075149311296258
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1B CACNA1C CACNA1D

7.66e-075149315451373
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-10 ERVK-18 ERVK-25 ERVK-11

9.45e-0718149418664271
Pubmed

Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.

CACNA1B CACNA1C CACNA1D

1.53e-066149316029198
Pubmed

Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes.

RXRA RXRB RXRG

1.53e-066149311328745
Pubmed

Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear.

RXRA RXRB RXRG

1.53e-06614939548551
Pubmed

Functional specificity of the two retinoic acid receptor RAR and RXR families in myogenesis.

RXRA RXRB RXRG

1.53e-06614939464546
Pubmed

RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells.

RXRA RXRB RXRG

1.53e-06614938801169
Pubmed

A decade of molecular biology of retinoic acid receptors.

RXRA RXRB RXRG

1.53e-06614938801176
Pubmed

Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma.

RXRA RXRB RXRG

1.53e-066149322205725
Pubmed

TGIF inhibits retinoid signaling.

RXRA RXRB RXRG

1.53e-066149316428452
Pubmed

A genetic dissection of the retinoid signalling pathway in the mouse.

RXRA RXRB RXRG

1.53e-066149310604193
Pubmed

The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains.

RXRA RXRB RXRG

1.53e-06614939153406
Pubmed

Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

RXRA RXRB RXRG

1.53e-066149320557428
Pubmed

The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.

RXRA RXRB RXRG

1.53e-06614939806918
Pubmed

Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.

RXRA RXRB RXRG

1.53e-06614937947324
Pubmed

Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis.

RXRA RXRB RXRG

1.53e-06614939075714
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

ABCA2 PNMA1 MAT2B EI24 CRY2 PTPN9 TMEM62 BCAP29 DHCR24 CLPTM1 CCR1 TMEM231 SLC26A11 MOG

2.00e-066971491428298427
Pubmed

Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.

RXRA RXRB RXRG

2.66e-06714939428411
Pubmed

Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases.

RXRA RXRB RXRG

2.66e-067149315635645
Pubmed

Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression.

RXRA RXRB RXRG

2.66e-06714938090775
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1C CACNA1D CACNA1F

2.66e-067149312900400
Pubmed

Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha.

RXRA RXRB RXRG

2.66e-067149311493527
Pubmed

Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions.

RXRA RXRB RXRG

2.66e-067149312360493
Pubmed

Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors.

RXRA RXRB RXRG

2.66e-067149317195188
Pubmed

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.

DCUN1D1 DCUN1D2 DCUN1D3

2.66e-067149315988528
Pubmed

The structure of the nuclear hormone receptors.

RXRA RXRB RXRG

2.66e-067149310406480
Pubmed

Analysis of the factors involved in the retinoic acid-induced differentiation of a retinoid-hypersensitive embryonal carcinoma cell mutant.

RXRA RXRB RXRG

2.66e-06714938299717
Pubmed

Dorsal and ventral rentinoic territories defined by retinoic acid synthesis, break-down and nuclear receptor expression.

RXRA RXRB RXRG

4.25e-068149310490294
Pubmed

Expression of nuclear retinoic acid receptors during mouse odontogenesis.

RXRA RXRB RXRG

4.25e-06814937988794
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1B CACNA1D CACNA1F

4.25e-068149328330839
Pubmed

Retinoids and adipose tissues: metabolism, cell differentiation and gene expression.

RXRA RXRB RXRG

4.25e-068149310094571
Pubmed

Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.

RXRA RXRB RXRG

4.25e-068149316043864
Pubmed

Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.

RXRA RXRB RXRG

4.25e-068149317124491
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1B CACNA1C CACNA1F

6.35e-069149316382099
Pubmed

A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells.

RXRA RXRB RXRG

6.35e-06914937823919
Pubmed

Enhancer activation requires trans-recruitment of a mega transcription factor complex.

RXRA RXRB RXRG

9.05e-0610149325303530
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

UNC13B CPLANE2 CPAMD8 TTLL3 TMEM222 SIRT4 TIAM2 STK16 BCAP29 TMEM245 UGT2A3 DHCR24 C3 DEPDC5 ATG9A ALDH3B2 MBD4 HYDIN

1.15e-0512931491815342556
Pubmed

Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.

RXRA RXRB RXRG

1.24e-0511149329093497
Pubmed

NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.

CACNA1C CACNA1D CACNA1F

1.24e-0511149318809727
Pubmed

Cholesterol and cholesterol plus DHA diet-induced gene expression and fatty acid changes in mouse eye and brain.

RXRA RXRB RXRG

1.65e-0512149315589691
Pubmed

The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.

DCUN1D1 DCUN1D2 DCUN1D3

1.65e-0512149319617556
Pubmed

Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse.

RXRA RXRB RXRG

1.65e-051214939022057
Pubmed

Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor.

RXRA RXRB RXRG

1.65e-0512149326427057
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ABCA2 MIA3 MAT2B EI24 ST3GAL2 ERMP1 LMBRD2 GXYLT2 BCAP29 CANT1 TMEM245 NAE1 CLPTM1 SEL1L3 PAM ST6GALNAC4 TMEM231

1.66e-0512011491735696571
Pubmed

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

RXRA RXRB

1.82e-05214927926783
Pubmed

The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.

PRKX PRKY

1.82e-05214927633447
Pubmed

MBD 4--a potential substrate for protein kinase X.

MBD4 PRKX

1.82e-052149221971312
Pubmed

Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.

CACNA1C CACNA1D

1.82e-052149221054386
Pubmed

Association of CYP19A1 and CYP1A2 genetic polymorphisms with type 2 diabetes mellitus risk in the Chinese Han population.

CYP1A2 CYP19A1

1.82e-052149232814585
Pubmed

Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.

RXRA RXRB

1.82e-052149224810760
Pubmed

Man to mouse--lessons learned from the distal end of the human X chromosome.

PRKX PRKY

1.82e-05214929414316
Pubmed

Limited degradation of retinoid X receptor by calpain.

RXRA RXRB

1.82e-05214928780715
Pubmed

Profiles of PrKX expression in developmental mouse embryo and human tissues.

PRKX PRKY

1.82e-052149215879576
Pubmed

Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.

CACNA1D CACNA1F

1.82e-052149225966695
Pubmed

Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.

RXRA RXRB

1.82e-052149222316320
Pubmed

An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

CACNA1C CACNA1D

1.82e-052149224086669
Pubmed

Genetic variant of RXR involved in the vitamin D metabolic pathway was linked to HCV infection outcomes among a high-risk Chinese population.

RXRA RXRB

1.82e-052149233246082
Pubmed

Endogenous retinoid X receptor ligands in mouse hematopoietic cells.

RXRA RXRB

1.82e-052149229089448
Pubmed

Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.

CACNA1C CACNA1D

1.82e-052149226049024
Pubmed

Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development.

RXRB RXRG

1.82e-05214929150186
Pubmed

Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.

CACNA1C CACNA1D

1.82e-052149219225208
Pubmed

Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.

CACNA1C CACNA1D

1.82e-052149216706838
Pubmed

Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.

CACNA1C CACNA1D

1.82e-052149223761887
Pubmed

Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.

CACNA1C CACNA1D

1.82e-052149214981074
Pubmed

CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.

CACNA1C CACNA1D

1.82e-052149225292336
Pubmed

Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.

CACNA1C CACNA1D

1.82e-052149217526649
Pubmed

Ligand-activated signal transduction in the 2-cell embryo.

CACNA1C CACNA1D

1.82e-052149212606379
Pubmed

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.

CACNA1C CACNA1D

1.82e-052149224941892
Pubmed

PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.

PRKX PRKY

1.82e-052149221684272
Pubmed

Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.

PRKX PRKY

1.82e-05214929302280
Pubmed

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.

RXRA RXRB

1.82e-052149216199515
Pubmed

Association between functional genetic variants in retinoid X receptor-α/γ and the risk of gestational diabetes mellitus in a southern Chinese population.

RXRA RXRG

1.82e-052149234633445
Pubmed

Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.

CACNA1C CACNA1D

1.82e-052149222826131
Pubmed

C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.

CACNA1D CACNA1F

1.82e-052149216921373
Pubmed

Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.

CACNA1C CACNA1D

1.82e-052149224470632
InteractionATP2A1 interactions

MIA3 STBD1 VEZT CFTR EI24 SMPD4 SYAP1 ATL1 CANT1 DHCR24 ALG10 CLPTM1 PIGW DDX24 MUL1

2.64e-0742314015int:ATP2A1
InteractionSCN11A interactions

CACNA1B CACNA1C CACNA1D SCN10A

2.87e-06151404int:SCN11A
InteractionHSD17B11 interactions

MIA3 STBD1 VEZT KIF16B EI24 SMPD4 SYAP1 ATL1 PTPN9 TMEM203 CANT1 DHCR24 CLPTM1

3.41e-0639014013int:HSD17B11
InteractionDERL1 interactions

CACNA1C MIA3 STBD1 VEZT FFAR2 CFTR EI24 SMPD4 WSB2 SYAP1 ATL1 DHCR24 CLPTM1

1.70e-0545314013int:DERL1
InteractionCACNA1D interactions

CACNA1B CACNA1C CACNA1D SCN10A

2.13e-05241404int:CACNA1D
InteractionUBE2F interactions

DCUN1D1 DCUN1D2 NAE1 DCUN1D3

3.46e-05271404int:UBE2F
InteractionTMT1A interactions

MIA3 STBD1 VEZT KIF16B EI24 SMPD4 SYAP1 ATL1 PTPN9 BCAP29 CLPTM1

4.30e-0535914011int:TMT1A
InteractionSCN1A interactions

CACNA1B CACNA1C CACNA1D SCN10A

4.63e-05291404int:SCN1A
InteractionTTYH1 interactions

ABCA2 MIA3 RDH12 ERMP1 LMBRD2 TMEM62 BCAP29 DHCR24 ALG10 PIGW

4.80e-0530014010int:TTYH1
InteractionHSD3B7 interactions

MIA3 STBD1 VEZT KIF16B EI24 SMPD4 SYAP1 ATL1 CANT1 DHCR24 CLPTM1

8.24e-0538614011int:HSD3B7
GeneFamilyOlfactory receptors, family 56

OR56B1 OR56A5 OR56A3 OR56A4 OR56A1

2.85e-109875167
GeneFamilyCalcium voltage-gated channel subunits

CACNA1B CACNA1C CACNA1D CACNA1F

6.90e-0626874253
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

CPAMD8 C3

8.06e-0498721234
GeneFamilyNuclear hormone receptors

RXRA RXRB RXRG

1.69e-034987371
GeneFamilyATP binding cassette subfamily A

ABCA2 ABCA5

2.01e-0314872805
GeneFamilyButyrophilins|V-set domain containing|C2-set domain containing

BTN1A1 MOG

2.31e-0315872458
GeneFamilySialyltransferases

ST3GAL2 ST6GALNAC4

4.11e-0320872438
CoexpressionHALLMARK_BILE_ACID_METABOLISM

ABCA2 IDI1 RXRA RXRG PAOX ABCA5 DHCR24

2.54e-061121417M5948
CoexpressionGSE9601_UNTREATED_VS_NFKB_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_DN

MAT2B VEZT EI24 PTPN9 FRRS1 BCAP29 HECTD2 LMBRD1

4.80e-061741418M6881
ToppCell15-Trachea-Epithelial-Secretory_progenitor|Trachea / Age, Tissue, Lineage and Cell class

CPAMD8 RAMP2 CFTR DHCR24 SEL1L3 PAM C3

2.37e-061871427be9fce9e74b2f170a2067f1b31d802912a578329
ToppCellIPF-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

PITPNM2 CPAMD8 CFTR SEL1L3 PAM C3 TANC1

2.82e-061921427356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFTR SLC5A1 DHCR24 UGT2A1 SEL1L3 PAM C3

3.13e-0619514272a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFTR SLC5A1 DHCR24 UGT2A1 SEL1L3 PAM C3

3.13e-061951427576142b4e75457c0973051bccc4163bd624496af
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFTR SLC5A1 DHCR24 UGT2A1 SEL1L3 PAM C3

3.13e-0619514278f151066ad3ebd9661ea0b733f03c2ce1518f9ad
Drugtriphenyltin hydroxide

CYP19A1 RXRA RXRB RXRG

2.28e-0861444ctd:C007567
DrugBexarotene

RXRA RXRB RXRG

2.48e-0731443DB00307
Drug2-hydroxyphytanic acid

RXRA RXRB RXRG

2.48e-0731443ctd:C002585
DrugAC1O5SBP

RXRA RXRB RXRG

2.48e-0731443CID006439746
Drugdi-n-propylphthalate

CYP1A2 RXRA RXRB RXRG

7.30e-07121444ctd:C106479
DrugAGN 190727

RXRA RXRB RXRG

9.87e-0741443CID006439768
DrugSulfonamides

CFTR RXRA RXRB RXRG

1.46e-06141444ctd:D013449
Drug7-methoxycitronellic acid

RXRA RXRB RXRG

2.45e-0651443CID000171516
Drug7-methoxycitronellal

RXRA RXRB RXRG

2.45e-0651443CID000019223
Drug13,14-dihydroretinol

RXRA RXRB RXRG

2.45e-0651443CID000446798
DrugVerapamil

CACNA1B CACNA1C CACNA1D CACNA1F

2.63e-06161444DB00661
Drug2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene

CYP1A2 CYP19A1 RXRA RXRB PAM

3.04e-06361445ctd:C054919
Drugisradipine

CACNA1B CACNA1C CACNA1D CYP1A2 CACNA1F PTGIR SCN10A

3.43e-061001447CID000003784
DrugA1-E

CACNA1C CACNA1D ABCA2 CFTR RDH12 BTN1A1

3.83e-06661446CID005326966
DrugAlitretinoin

RXRA RXRB RXRG

4.89e-0661443DB00523
DrugAdapalene

RXRA RXRB RXRG

4.89e-0661443DB00210
DrugEtretinate

RXRA RXRB RXRG

4.89e-0661443DB00926
DrugAcitretin

RXRA RXRB RXRG

8.51e-0671443DB00459
DrugAmlodipine

CACNA1B CACNA1C CACNA1D

8.51e-0671443DB00381
DrugAGN 190121

RXRA RXRB RXRG

8.51e-0671443CID006441236
DrugAGN 191659

RXRA RXRB RXRG

8.51e-0671443CID006366726
Drugnisoldipine

CACNA1B CACNA1C CACNA1D CYP1A2 CACNA1F SLC5A1

1.02e-05781446CID000004499
Drugfelodipine

CACNA1B CACNA1C CACNA1D CYP1A2 CACNA1F PDE3A CYP19A1 CFTR

1.25e-051691448CID000003333
Drugdiethyl phthalate

CYP1A2 CYP19A1 RXRA RXRB RXRG

1.30e-05481445ctd:C007379
DrugTTNN

RXRA RXRB RXRG

1.36e-0581443CID000135754
DrugHX 600

RXRA RXRB RXRG

1.36e-0581443ctd:C104181
DrugAC1O5JP6

RXRA RXRB RXRG

1.36e-0581443CID006435379
Drug5 alpha-androstane

CYP19A1 RXRA RXRB RXRG CRY2 UGT2A1

1.56e-05841446CID000094144
DrugLinuron

CACNA1B CACNA1C CACNA1D CYP19A1 IDI1 RXRA RPTOR

1.75e-051281447ctd:D008044
DrugCinnarizine

CACNA1C CACNA1D CACNA1F

2.02e-0591443DB00568
DrugNimodipine

CACNA1C CACNA1D CACNA1F

2.02e-0591443DB00393
DrugPrt-H

RXRA RXRB RXRG C3

2.06e-05261444CID003050291
DrugHX 630

RXRA RXRB RXRG

2.88e-05101443ctd:C422175
Drugdiazepinylbenzoic acid

RXRA RXRB RXRG

2.88e-05101443ctd:C438269
DrugMDHT

CYP19A1 RDH12 ALDH3B2

2.88e-05101443CID000003170
Drugnilvadipine

CACNA1B CACNA1C CACNA1D CYP1A2 CACNA1F

3.90e-05601445CID000004494
DrugAGN 191701

RXRA RXRB RXRG

3.94e-05111443CID006438168
DrugMibefradil

CACNA1C CACNA1D CACNA1F

3.94e-05111443DB01388
DrugMusk T

RXRA RXRB RXRG

3.94e-05111443CID000061014
DrugUVI 3003

RXRA RXRB RXRG

3.94e-05111443ctd:C525131
DrugIAA-94

CACNA1B CACNA1C CACNA1D CACNA1F CFTR

4.22e-05611445CID000003667
DrugAGN 193109

CYP1A2 RXRA RXRB RXRG

4.23e-05311444CID000177238
DrugNSC46155

RXRA RXRB RXRG

5.23e-05121443CID000457869
DrugCNS 1145

CACNA1B CACNA1C CACNA1D CACNA1F

5.44e-05331444CID000190902
DrugIHC-64

CACNA1B CACNA1C CACNA1D CACNA1F

5.44e-05331444CID000162753
DrugRetinoids

RDH12 RXRA RXRB RXRG

6.14e-05341444ctd:D012176
Drugtazarotenic acid

RXRA RXRB RXRG

6.76e-05131443CID000147525
DrugGW2331

RXRA RXRB RXRG

6.76e-05131443CID000657048
DrugCd2665

RXRA RXRB RXRG

6.76e-05131443CID000216241
DrugAC1L1DMQ

RXRA RXRB RXRG

8.57e-05141443CID000002418
DrugAC1L1JG6

CACNA1B CACNA1C CACNA1D

8.57e-05141443CID000005026
DrugBarium

TRPM6 CACNA1B CACNA1C CACNA1D CACNA1F

9.39e-05721445ctd:D001464
DrugCAS 298-57-7

CACNA1B CACNA1C CACNA1D CACNA1F PTGIR

1.00e-04731445CID000002761
Drug2,2,2-trichloroethanol

CYP1A2 CYP19A1 SLC5A1 UGT2A3 UGT2A1

1.00e-04731445CID000008259
Drugretinoic acid; Up 200; 1uM; MCF7; HT_HG-U133A_EA

NPL CACNA1D HTR1E VEZT AJAP1 CLCN5 SCN10A

1.10e-041711447991_UP
Druglavendustin A

CACNA1B CACNA1C CACNA1D CACNA1F RHBDF1 CFTR PAOX

1.10e-041711447CID000003894
Drugcitalopram

CACNA1C CACNA1D CYP1A2 DDT SLC6A2 TMEM245

1.17e-041201446CID000002771
Drugacyclic retinoid

RXRA RXRB RXRG PAM

1.30e-04411444CID006437836
Drugpapaverine

CACNA1B CACNA1C CACNA1D CACNA1F PDE3A CFTR PTGIR

1.32e-041761447CID000004680
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1B CACNA1C CACNA1D CACNA1F NOX5

1.46e-04791445CID005287890
Drugphthalic acid

RXRA RXRB RXRG

1.58e-04171443ctd:C032279
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

3.73e-0741353DOID:0060173 (implicated_via_orthology)
DiseaseIschemic stroke

PDE3A SLC6A2 AJAP1 EML5 USP38 RXFP2 TMEM184C SLC26A11 TNR

1.93e-053241359HP_0002140
DiseaseHeart Block

CACNA1D SCN10A

1.24e-0441352C0018794
DiseaseAuriculo-Ventricular Dissociation

CACNA1D SCN10A

1.24e-0441352C0004331
Diseaseleptin measurement

GPR15 NOX5 DCUN1D1 ALG10

5.31e-04811354EFO_0005000
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

5.99e-04361353DOID:11723 (implicated_via_orthology)
Diseaseanterior uveitis (biomarker_via_orthology)

CCR1 C3

7.32e-0491352DOID:1407 (biomarker_via_orthology)
DiseaseShortened QT interval

CACNA1C SCN10A

1.11e-03111352C0151879
Disease5-acetylamino-6-amino-3-methyluracil measurement

CYP1A2 SLC6A2

1.11e-03111352EFO_0800951
Diseasealpha angle measurement

CYP19A1 TIAM2

1.11e-03111352EFO_0020071
Diseaseparaxanthine measurement

CYP1A2 NOX5

1.33e-03121352EFO_0021178
Diseaseocular hypertension, response to triamcinolone acetonide

GCFC2 TTLL3 FRRS1

1.48e-03491353EFO_0006954, EFO_1001069
Diseaseepisodic memory

TRPM6 FASTKD2 RXFP2

1.76e-03521353EFO_0004333
Diseaseearly cardiac repolarization measurement

AKR1C8 PAM

1.82e-03141352EFO_0004885
Diseaseinterleukin 1 receptor antagonist measurement

TRANK1 SPAG16 SLC26A11

1.86e-03531353EFO_0004754
DiseaseSinus Node Dysfunction (disorder)

CACNA1D SCN10A

2.10e-03151352C0428908
Diseasephosphatidylcholine 38:6 measurement

FASTKD2 DEPDC5

2.39e-03161352EFO_0010388
DiseaseAntibody Deficiency Syndrome

CACNA1C C3

2.70e-03171352C0003257
DiseaseCalcium channel blocker use measurement

CACNA1C CACNA1D USP38 RXFP2 SLC4A10

3.04e-032131355EFO_0009930
DiseaseCOVID-19 (is_implicated_in)

TLR7 C3

4.12e-03211352DOID:0080600 (is_implicated_in)
DiseaseManic Disorder

CACNA1C CACNA1D TRANK1

4.27e-03711353C0024713
DiseaseAgents acting on the renin-angiotensin system use measurement

CACNA1C CACNA1D CYP1A2 MIA3 USP38 RXFP2

4.52e-033351356EFO_0009931

Protein segments in the cluster

PeptideGeneStartEntry
TKAWFIAGIFLLLTI

TMEM184C

46

Q9NVA4
SFADLIFGKWPVVLI

TMEM62

301

Q0P6H9
ILIESFPKSLVWLFS

ABCA5

346

Q8WWZ7
IKLWATFFRAELVHP

AKR1C8

86

Q5T2L2
LVPFLLLIPKFARWF

ARSH

176

Q5FYA8
SVPWKVIFVFALLAF

ARSH

191

Q5FYA8
VVSKLFFSWTRPILR

CFTR

11

P13569
PLKLTLEVAAWFILL

CATSPER2

141

Q96P56
LEVAAWFILLIFILE

CATSPER2

146

Q96P56
LELRWFRKKVSPAVL

BTN1A1

61

Q13410
ITRFLWPKEVELLLK

CARMIL2

16

Q6F5E8
IKLIWSLVALIFTFF

GPR15

191

P49685
KIIFIVVAAFLVSWL

GPR15

241

P49685
ILGAFILSWLPFFIK

HTR1E

296

P28566
ILSWLPFFIKELIVG

HTR1E

301

P28566
LIPVAFVSEKWFEIS

AJAP1

396

Q9UKB5
LQLKDFDFVPPVVRW

C3

1241

P01024
TFWNKAFLTIIILLI

BCAP29

46

Q9UHQ4
PVVVLLAIAIFIRWK

PAM

876

P19021
SVFIWKEPFGLVLII

ALDH3B2

16

P48448
RILLWTFVQSFKALP

CACNA1B

1586

Q00975
DPASISVLIIAWKFR

DCUN1D1

96

Q96GG9
DPTEFRVLLLAWKFQ

DCUN1D3

121

Q8IWE4
FISAVWVAFPLLTKL

ERMP1

551

Q7Z2K6
VFVPYRDSVLTWLLK

KIF16B

306

Q96L93
LIPFLITLVVWRSKD

RAMP2

156

O60895
FCLVFWVLKGLRPRV

CYP1A2

21

P05177
EVLAKWEIFLFLAIL

CYP1A2

461

P05177
LIRGRIFFKIWPLSD

IMMP1L

136

Q96LU5
ARLKKVLIVGAPIWF

PTPN9

181

P43378
KWLLVPGILFFLEKA

NOX5

421

Q96PH1
LCLTVIPKVLAIFWF

OR56A4

76

Q8NGH8
IPKVLAIFWFDLRSI

OR56A4

81

Q8NGH8
LLWRLFSPFVKTARE

RDH12

246

Q96NR8
ISIVEWKPFDILILL

CACNA1F

86

O60840
WKPFDILILLTIFAN

CACNA1F

91

O60840
IESLKFWRTRFLLLP

DEPDC5

936

O75140
LLPFKIIEAASNFRW

FFAR2

61

O15552
FRIGIKESLWPFLID

MAT2B

311

Q9NZL9
LAFLVLVALVWFLVE

NCR1

261

O76036
LRPLKIVWGIFFILV

LMBRD1

301

Q9NUN5
KLPDIALDVFALWLV

FRMD8P1

66

Q9BZ68
TKEWFLLLIRQIFHP

HECTD2

461

Q5U5R9
DPASISVLVIAWKFR

DCUN1D2

96

Q6PH85
PRWKVILTFFVGAAI

CANT1

41

Q8WVQ1
LISLERFKVAWRPYL

PDE3A

226

Q14432
ILIRFFPLESWQIGK

DDT

96

P30046
VLFLRPVDDIWKLLR

GXYLT2

216

A0PJZ3
IIPKILAIFWFDAKV

OR56B1

86

Q8NGI3
LAIFWFDAKVISLPE

OR56B1

91

Q8NGI3
WPLIIIDLKDCFFTI

HERVK_113

116

P63132
SVRLWKVLALVFGFA

MUL1

236

Q969V5
LTDVKDFSLPLWLIF

MFSD1

256

Q9H3U5
ILELPWFKSTSVILF

GNA15

261

P30679
SWFRSILPKAALRVV

PITPNM2

71

Q9BZ72
WPLIIIDLKDCFFTI

ERVK-7

116

P63135
WPLIIIDLKDCFFTI

ERVK-6

116

Q9BXR3
FLRVPCWKITLFVIV

MOG

201

Q16653
KELHTIFPWLVESIF

SMPD4

81

Q9NXE4
LLFFWVTKRKLEVPT

GALNT14

21

Q96FL9
LCLTVIPKVLAIFWF

OR56A5

76

P0C7T3
IPKVLAIFWFDLRSI

OR56A5

81

P0C7T3
WPLIIIDLKDCFFTI

ERVK-18

116

Q9QC07
TAFRQAWELPLLRVK

CPLANE2

191

Q9BU20
IKSFGLDRIIDIWIL

FBH1

776

Q8NFZ0
PLVVKFRWFFLVNDE

HYDIN

1196

Q4G0P3
IKITPWFKIIAATFL

IDI1

191

Q13907
QITEAKRPVFIFEWL

HEATR5B

16

Q9P2D3
LKPFQSLIFLVRDWS

ATL1

206

Q8WXF7
VEWKPFEIIILLTIF

CACNA1C

121

Q13936
KELWFRAAVIAVPIA

BAMBI

146

Q13145
ALLIKPDIFFKISWL

CYP19A1

226

P11511
DVFPRLFKEWGVTRL

CRY2

101

Q49AN0
KTIIPRLTDFVEFLW

GCFC2

556

P16383
AVHLVKWLPFLSVDR

CCR1

321

P32246
KWLPFLSVDRLERVS

CCR1

326

P32246
VARFFKPVWSKAFLL

FRRS1

391

Q6ZNA5
ALLFLLWVRLKGLEF

DHCR24

11

Q15392
FSALWVLPLFVLSKV

EI24

126

O14681
LVIAGVFWIHRLIKF

ATG9A

136

Q7Z3C6
IFVDPRELAAAKSWI

CPAMD8

1226

Q8IZJ3
WALLFAFLAVSLVKV

CLCN5

216

P51795
TLKRRSPWVLAFEIF

ABCA2

16

Q9BZC7
VAWLLEKFGLRTIAL

FLVCR2

141

Q9UPI3
TLFHDPWKLLIATIF

MBD4

451

O95243
VSAWKDLFVPRPVLR

DDX24

191

Q9GZR7
LWDLTFKPITVIDLR

EML5

261

Q05BV3
PLVESIWYKRLTLFS

PNMA1

151

Q8ND90
LLIFIIINWAAVKAF

SPACA1

236

Q9HBV2
LFTLVEWAKRIPHFS

RXRA

276

P19793
SIVEWKPFDIFILLA

CACNA1D

121

Q01668
PKVLAIFWYDLRSIS

OR56A1

86

Q8NGH5
LQDAWFRKLIGFVVL

PAOX

356

Q6QHF9
IAPFFLKPWTKDILI

NPL

111

Q9BXD5
KRSVLVILWILAFLA

RNFT2

211

Q96EX2
WKFVSPAFLLFVVVV

SLC6A2

521

P23975
TKFIIPLKEWFRLDI

SEL1L3

346

Q68CR1
RKLILASFAVWLAVL

TMEM265

76

A0A087WTH1
LLLPFFKRGTLWNEI

STK16

96

O75716
ASFAIFLWRTVLVVK

MIA3

1191

Q5JRA6
LRPWFYKILAVVLSI

LMBRD2

381

Q68DH5
NLLKAETTFWVLPVF

NEXMIF

1491

Q5QGS0
FDIWKFRKVLFILIL

FASTKD2

411

Q9NYY8
LKEVSHPFLIRLFWT

PRKY

101

O43930
LARPWRAFFKLLAVV

RHBDF1

741

Q96CC6
IAAFYRKEWPLLVVV

SMARCAL1

471

Q9NZC9
LVPFKVLDLLWIASA

ST3GAL2

216

Q16842
FILTAWEKKLPIAIL

SIRT4

271

Q9Y6E7
WIPVFVVKILSLFRV

RXFP2

651

Q8WXD0
ISKFPAWLKLIVTVR

TANC1

616

Q9C0D5
VIPKVLTIFWFDLRP

OR56A3

81

Q8NH54
FALVPKLVKEEVFWR

SYAP1

186

Q96A49
PLTGRRWKIFFAEEI

MROH2B

1416

Q7Z745
ELRPLLVFIWAKILA

RPTOR

486

Q8N122
HSLQKRWIEVFIPRF

SERPINA9

296

Q86WD7
PTWKTRFLTDFVVLI

PIGW

51

Q7Z7B1
WNFFFTIIVVKLITP

PIGW

236

Q7Z7B1
QLFTLVEWAKRIPHF

RXRB

346

P28702
WRFLKRDVQIPFVVE

ACOT4

91

Q8N9L9
LSLVWKRRILFFVVT

ALG10

316

Q5BKT4
IKGVLFRIFIIWAIS

CLPTM1

56

O96005
VWKFLKTIPDLTFQL

CNBD1

156

Q8NA66
WLLDPKILKFVVFIV

TNFRSF10D

31

Q9UBN6
WPLIIIDLKDCFFTI

ERVK-25

116

P63136
TLWVFPPLKRLFLEK

TRIML2

351

Q8N7C3
LLIWFKREFPFPDVL

TBC1D17

496

Q9HA65
LFLIFLLWKLPSARA

TPRA1

56

Q86W33
ILWEITRFFLLAIEL

TPRA1

116

Q86W33
AVFSRWAKKRPIVFA

ST6GALNAC4

281

Q9H4F1
FIVKSFLPEVVRTWH

TRPM6

1801

Q9BX84
VVRKAGWLFFKPLVT

TIAM2

506

Q8IVF5
LDPFKFRWLIPISAL

TIAM2

1386

Q8IVF5
IFLPADTVVEWKFVL

STBD1

311

O95210
APLFDTKIFRTLWRV

SLC26A11

416

Q86WA9
ILDPWVFILFRKAVF

PTGIR

286

P43119
WLFSPFNLIRRTAIK

SCN10A

111

Q9Y5Y9
LLWIIKVSRAAIVFP

SLC4A10

996

Q6U841
LWDFRKLLPIVSIDI

SPAG16

546

Q8N0X2
WPLIIIDLKDCFFTI

ERVK-10

116

P10266
FVEWIPPRAKVDFIL

TNR

521

Q92752
WPLIIIDLKDCFFTI

ERVK-8

116

P63133
ADLKRIFWVLSLPII

SLC24A5

301

Q71RS6
WPLIIIDLKDCFFTI

ERVK-11

116

Q9UQG0
QLFTLVEWAKRIPHF

RXRG

276

P48443
IKPQFFAFRWLTLLL

TBC1D13

311

Q9NVG8
SIRNLDFWPKLITLI

UNC13B

961

O14795
RPLLIFGTKFDLRQW

TTLL3

326

Q9Y4R7
LKEVSHPFLIRLFWT

PRKX

101

P51817
PKVTEIFERILFIWA

TBC1D22A

296

Q8WUA7
FNIILISKLLGARWF

TLR7

16

Q9NYK1
LLKIELVFNRLWFPL

USP38

311

Q8NB14
VLRLFWVLTVLSLKF

TMEM203

81

Q969S6
VGAFVKTWLPFILLL

TMEM222

181

Q9H0R3
AGSWRIPVFLVIVFL

TMEM245

236

Q9H330
ILLIFLWVFERIKIF

TMEM231

276

Q9H6L2
PVKPLDRAVFWIEFV

UGT2A3

451

Q6UWM9
FPFSRPELLKEWVLN

THAP3

26

Q8WTV1
LLRIWALELKTPIAF

WSB2

316

Q9NYS7
FSLPALKVLFQLWVA

VEZT

326

Q9HBM0
TVFKFLLEKQRWPEV

TRANK1

386

O15050
PIAAVFLLAIFWKRV

SLC5A1

466

P13866
TPSFWILARALKEFV

NAE1

301

Q13564
PVKPLDRAVFWIEFV

UGT2A1

451

P0DTE4
IRLDAFWLKVSFPLE

UHRF1BP1

581

Q6BDS2