Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine N-sulfotransferase activity

NDST1 NDST2 NDST4

2.29e-074783GO:0015016
GeneOntologyMolecularFunctionN-acetylglucosamine deacetylase activity

NDST1 NDST2 NDST4

2.29e-074783GO:0050119
GeneOntologyMolecularFunctionheparan sulfate sulfotransferase activity

NDST1 NDST2 NDST4

2.52e-0515783GO:0034483
GeneOntologyMolecularFunctionheparan sulfate N-deacetylase activity

NDST1 NDST2

4.51e-053782GO:0102140
GeneOntologyMolecularFunctiondeacetylase activity

NDST1 NDST2 NDST4

5.11e-0440783GO:0019213
GeneOntologyMolecularFunctionintegrin binding

FAP VWF ITGAD ITGAL FRMD5

6.15e-04175785GO:0005178
GeneOntologyBiologicalProcessheparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

NDST1 NDST2 NDST4

2.87e-068783GO:0015014
GeneOntologyBiologicalProcessheparin biosynthetic process

NDST1 NDST2 NDST4

8.40e-0611783GO:0030210
GeneOntologyBiologicalProcessheparin metabolic process

NDST1 NDST2 NDST4

3.41e-0517783GO:0030202
DomainHSNSD

NDST1 NDST2 NDST4

2.90e-074793PF12062
DomainHeparan_SO4_deacetylase

NDST1 NDST2 NDST4

2.90e-074793IPR021930
DomainVWA

CACNA2D1 VWF CACHD1 ITGAD ITGAL

3.84e-0656795PF00092
DomainVWFA

CACNA2D1 VWF CACHD1 ITGAD ITGAL

2.52e-0582795PS50234
DomainVWA

CACNA2D1 VWF CACHD1 ITGAD ITGAL

2.83e-0584795SM00327
DomainVWF_A

CACNA2D1 VWF CACHD1 ITGAD ITGAL

6.24e-0599795IPR002035
DomainVWA_N

CACNA2D1 CACHD1

1.75e-045792IPR013608
DomainVWA_N

CACNA2D1 CACHD1

1.75e-045792PF08399
DomainCullin_CS

CUL1 CUL9

3.66e-047792IPR016157
DomainSulfotransferase_dom

NDST1 NDST2 NDST4

4.70e-0436793IPR000863
DomainSulfotransfer_1

NDST1 NDST2 NDST4

4.70e-0436793PF00685
DomainCullin_Nedd8

CUL1 CUL9

4.87e-048792PF10557
DomainCullin_Nedd8

CUL1 CUL9

4.87e-048792SM00884
DomainCullin_neddylation_domain

CUL1 CUL9

4.87e-048792IPR019559
DomainCullin_homology

CUL1 CUL9

6.24e-049792IPR016158
DomainCullin

CUL1 CUL9

7.78e-0410792PF00888
DomainCULLIN_2

CUL1 CUL9

7.78e-0410792PS50069
DomainCullin_N

CUL1 CUL9

7.78e-0410792IPR001373
DomainCULLIN_1

CUL1 CUL9

7.78e-0410792PS01256
DomainPSI

SEMA3C ATRNL1 SEMA3G

8.51e-0444793IPR016201
DomainIntegrin_alpha

ITGAD ITGAL

9.48e-0411792PF00357
DomainPSI

SEMA3C ATRNL1 SEMA3G

9.70e-0446793SM00423
DomainIntegrin_alpha_C_CS

ITGAD ITGAL

2.04e-0316792IPR018184
DomainConA-like_dom

LAMA4 ADGRV1 HNRNPUL1 HERC1 RSPRY1

2.36e-03219795IPR013320
DomainIntegrin_alpha-2

ITGAD ITGAL

2.59e-0318792IPR013649
DomainIntegrin_alpha2

ITGAD ITGAL

2.59e-0318792PF08441
DomainIntegrin_alpha

ITGAD ITGAL

2.59e-0318792IPR000413
DomainINTEGRIN_ALPHA

ITGAD ITGAL

2.59e-0318792PS00242
DomainInt_alpha_beta-p

ITGAD ITGAL

2.88e-0319792IPR013519
DomainInt_alpha

ITGAD ITGAL

2.88e-0319792SM00191
DomainSemaphorin

SEMA3C SEMA3G

3.19e-0320792IPR027231
Domain-

CACNA2D1 VWF CACHD1

3.81e-03747933.40.50.410
DomainFG_GAP

ITGAD ITGAL

3.86e-0322792PS51470
DomainFG-GAP

ITGAD ITGAL

4.59e-0324792PF01839
DomainFG-GAP

ITGAD ITGAL

4.59e-0324792IPR013517
DomainIntegrin_dom

ITGAD ITGAL

4.98e-0325792IPR032695
DomainSPRY

HNRNPUL1 HERC1 RSPRY1

5.98e-0387793SM00449
DomainEGF_LAM_2

ATRNL1 LAMA4

7.12e-0330792PS50027
DomainEGF_LAM_1

ATRNL1 LAMA4

7.12e-0330792PS01248
DomainSPRY

HNRNPUL1 HERC1 RSPRY1

7.41e-0394793PF00622
DomainSPRY_dom

HNRNPUL1 HERC1 RSPRY1

7.41e-0394793IPR003877
DomainSema

SEMA3C SEMA3G

7.59e-0331792SM00630
DomainSemap_dom

SEMA3C SEMA3G

7.59e-0331792IPR001627
DomainSema

SEMA3C SEMA3G

7.59e-0331792PF01403
DomainSEMA

SEMA3C SEMA3G

7.59e-0331792PS51004
DomainB30.2/SPRY

HNRNPUL1 HERC1 RSPRY1

7.63e-0395793IPR001870
PathwayKEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS

NDST1 NDST2 NDST4

1.37e-0511633M47921
PathwayKEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE

NDST1 NDST2 NDST4

2.06e-0426633M7330
PathwayWP_HIPPOCAMPAL_SYNAPTOGENESIS_AND_NEUROGENESIS

PPARGC1A DRD1 HNRNPL

2.30e-0427633M45550
PathwayREACTOME_HS_GAG_BIOSYNTHESIS

NDST1 NDST2 NDST4

2.86e-0429633MM14802
PathwayREACTOME_HS_GAG_BIOSYNTHESIS

NDST1 NDST2 NDST4

3.50e-0431633M685
Pubmed

Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.

NDST1 NDST2 NDST4

4.50e-08479322049073
Pubmed

Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.

NDST1 NDST2 NDST4

4.50e-08479312070138
Pubmed

Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.

NDST1 NDST2 NDST4

1.12e-07579311087757
Pubmed

FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.

NDST1 NDST2 NDST4

6.27e-07879324067353
Pubmed

Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.

NDST1 NDST2 NDST4

1.84e-061179315944372
Pubmed

Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.

NDST1 NDST2 NDST4

2.45e-061279312460940
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

NPC1 NDST1 CACNA2D1 FAP SEMA3C FANCI UGGT1 FKBP9 LAMA4 CACHD1 ECE1 SLC33A1 FRMD5

2.96e-061201791335696571
Pubmed

N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.

NDST1 NDST2

5.09e-06279223060443
Pubmed

Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns.

NDST1 NDST2

5.09e-06279210758005
Pubmed

Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2.

NDST1 NDST2

5.09e-06279212634318
Pubmed

cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin.

NDST1 NDST2

5.09e-0627928144627
Pubmed

Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes.

NDST1 NDST2

5.09e-0627929565617
Pubmed

Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells.

NDST1 NDST2

5.09e-06279222298785
Pubmed

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.

PTPN22 ITGAL

5.09e-06279230054208
Pubmed

Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.

NDST1 NDST2

5.09e-06279215319440
Pubmed

Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.

NDST1 NDST2

5.09e-06279216984905
Pubmed

Heparin/heparan sulfate biosynthesis: processive formation of N-sulfated domains.

NDST1 NDST2

5.09e-06279218487608
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

RALGAPA1 SERPINB6 MYO9A GPR137B MACF1 SCAF11 ADGRV1 PPM1K CAMTA1 CLEC16A STAG2 HNRNPL SBNO2 PDZD2

5.99e-061489791428611215
Pubmed

Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.

NDST1 NDST2 NDST4

1.25e-052079317107998
Pubmed

Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis.

NDST1 NDST2

1.53e-05379222345168
Pubmed

Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.

NDST1 NDST2

1.53e-0537929915799
Pubmed

Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate.

NDST1 NDST2

1.53e-05379218479348
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KNTC1 SACS ATRNL1 MACF1 KCNS2 FANCM ATP8B2 RSPRY1

1.67e-0549379815368895
Pubmed

NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.

NDST1 NDST2 NDST4

1.68e-052279319299468
Pubmed

SHARPIN regulates uropod detachment in migrating lymphocytes.

ITGAD ITGAL

3.05e-05479224210817
Pubmed

Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation.

NDST1 NDST2

3.05e-05479229688404
Pubmed

Heparan sulfate structure in mice with genetically modified heparan sulfate production.

NDST1 NDST2

3.05e-05479215292174
Pubmed

FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.

CUL1 HNRNPL

3.05e-05479234333526
Pubmed

Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses.

NDST1 NDST2

3.05e-05479216056228
Pubmed

Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition.

FANCI FANCM

3.05e-05479219737859
Pubmed

Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes.

ITGAD ITGAL

5.07e-05579215210787
Pubmed

CD11a regulates hematopoietic stem and progenitor cells.

ITGAD ITGAL

5.07e-05579237781399
Pubmed

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development.

NDST1 NDST2

5.07e-05579217289920
Pubmed

CD11c regulates hematopoietic stem and progenitor cells under stress.

ITGAD ITGAL

5.07e-05579233351105
Pubmed

Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.

NDST1 NDST2

7.60e-05679219915053
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

CACNA2D1 DRD1 NACC1 CUL9 PTPN22 ADGRV1 ECE1 CLEC16A PDZD2

9.61e-0581479923251661
Pubmed

Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.

CUL1 CCNE2 TFDP2

9.72e-053979319738611
Pubmed

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

PTPN22 CLEC16A

1.06e-04779217632545
Pubmed

Altered heparan sulfate structure in mice with deleted NDST3 gene function.

NDST1 NDST2

1.06e-04779218385133
Pubmed

The methionine synthase (Mtr) gene maps to proximal mouse chromosome 13.

SERPINB6 GPR137B

1.06e-0477929321480
Pubmed

Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate.

NDST1 NDST2

1.06e-04779235608020
Pubmed

The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.

FANCI FANCM

1.06e-04779224451376
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ACSL3 FANCI UGGT1 CUL9 MACF1 SCAF11 HNRNPUL1 STAG2

1.20e-0465379822586326
Pubmed

Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin.

VWF ITGAL

1.41e-0487928562500
Pubmed

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.

PTPN22 CLEC16A

1.41e-04879219264985
Pubmed

Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice.

SEMA3C SEMA3G

1.41e-04879220006658
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NPC1 PPARGC1A ATRNL1 UGGT1 MACF1 HERC1 CAMTA1 SLC33A1 STAG2 SBNO2

1.70e-041084791011544199
Pubmed

Genetic epistasis between heparan sulfate and FGF-Ras signaling controls lens development.

NDST1 NDST2

1.82e-04979221536023
Pubmed

A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships.

NDST1 NDST2

1.82e-04979230377379
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

CUL9 MACF1 CACHD1 PDZD2

2.25e-0413079412421765
Pubmed

Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.

PTPN22 CLEC16A

2.27e-041079219951419
Pubmed

Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress.

ACSL3 CUL1 HERC1

2.30e-045279328947420
Pubmed

Class 3 semaphorins negatively regulate dermal lymphatic network formation.

SEMA3C SEMA3G

2.76e-041179226319580
Pubmed

Forkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage response.

FANCI FANCM

2.76e-041179226625197
Pubmed

Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.

VWF IRX4

2.76e-041179210926765
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

NDST1 CUL9 CAMTA1 CLEC16A

3.16e-0414279419851296
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

NDST1 CUL9 CAMTA1 CLEC16A

3.24e-0414379420198315
Pubmed

Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.

SEMA3C SEMA3G

3.31e-041279219812329
Pubmed

Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.

SEMA3C SEMA3G

3.31e-041279223991118
Pubmed

Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction.

NDST1 NDST2

3.31e-041279218077586
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

ACSL3 CUL1 KNTC1 FANCI UGGT1 SCAMP2 FGD5 HNRNPUL1 STAG2 HNRNPL MGAM2

3.68e-041425791130948266
Pubmed

The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.

RALGAPA1 HNRNPUL1 ITGAD

3.87e-046279319710015
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

CUL1 FANCI MACF1 ADGRV1

4.08e-0415279434299191
Pubmed

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.

CUL9 HNRNPUL1

4.55e-041479222653443
Pubmed

Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.

VWF LAMA4

4.55e-041479236347239
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

NDST1 SERPINB6 FANCI UGGT1 HERC1

4.90e-0428579532838362
Pubmed

The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.

FANCI FANCM

5.25e-041579219536649
Pubmed

Whole genome association scan for genetic polymorphisms influencing information processing speed.

ATRNL1 FAM110C

5.99e-041679221130836
Pubmed

Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.

SEMA3C GCM2

5.99e-041679218489001
Pubmed

A protein interaction landscape of breast cancer.

CCNE2 FANCI UGGT1 CUL9 MACF1 SCAF11 TFDP2

6.03e-0463479734591612
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RALGAPA1 ACSL3 FANCI UGGT1 PTPN22 CACHD1 PPM1K HERC1 HNRNPL

6.20e-04104979927880917
Pubmed

Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.

DRD1 MACF1

6.78e-041779220395553
Pubmed

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

PTPN22 CLEC16A

6.78e-041779217554260
Pubmed

Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7.

ACSL3 AIFM2

6.78e-041779214741744
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

NPC1 CACNA2D1 AIFM2 SERPINB6 UGGT1 LAMA4 ELF5 ECE1 SPATA32 SBNO2

6.84e-041293791015342556
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

SEMA3C AIFM2 ECE1 CLEC16A SLC33A1 RSPRY1 SBNO2

6.98e-0465079738777146
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

NPC1 ACSL3 CACNA2D1 SEMA3C SERPINB6 UGGT1 FKBP9 MACF1 HNRNPUL1 ECE1

7.00e-041297791033545068
Pubmed

Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.

NDST1 NDST2 NDST4

8.47e-048179339217171
Pubmed

PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.

SEMA3C VWF

8.50e-041979215239958
Pubmed

Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development.

NDST1 NDST2

9.43e-042079222745308
Pubmed

Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis.

NDST1 NDST2

9.43e-042079224753163
Pubmed

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

PTPN22 CLEC16A

9.43e-042079218978792
Pubmed

Shared and distinct genetic variants in type 1 diabetes and celiac disease.

PTPN22 CLEC16A

1.04e-032179219073967
Pubmed

Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.

SEMA3C SEMA3G

1.04e-032179236240771
Pubmed

Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.

CUL1 SCAF11

1.14e-032279226631746
Pubmed

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

CUL1 FANCM

1.25e-032379222017875
Pubmed

Fanconi Anemia

FANCI FANCM

1.25e-032379220301575
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

CUL1 NDST1 CENPI MACF1 HERC1 ECE1 SLC33A1

1.25e-0371979735337019
Pubmed

Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.

SEMA3C IRX4 TFDP2

1.34e-039579321440680
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

CUL9 HERC1 RSPRY1

1.34e-039579329643511
Pubmed

A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.

CUL1 CCNE2

1.36e-032479216620772
Pubmed

Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.

NDST1 NDST2

1.36e-032479234653670
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

ACSL3 CUL1 CCNE2 KCNS2 SCAMP2 SEMA3G ECE1

1.37e-0373079734857952
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

NPC1 FANCI CUL9 ECE1

1.46e-0321479422199357
Pubmed

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

PTPN22 CLEC16A

1.48e-032579221829393
Pubmed

Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.

CUL1 AGBL4

1.48e-032579229593216
Pubmed

Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects.

SEMA3C IRX4

1.48e-032579231341279
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

ACSL3 CUL1 KNTC1 CACNA2D1 CCNE2 FANCI UGGT1 HNRNPUL1 STAG2 HNRNPL

1.54e-031440791030833792
Pubmed

Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression.

UGGT1 HNRNPUL1 HERC1

1.65e-0310279331623628
Pubmed

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.

CUL1 ADGRV1

1.72e-032779234709416
GeneFamilySulfotransferases, membrane bound

NDST1 NDST2 NDST4

2.49e-0437603763
GeneFamilyCullins

CUL1 CUL9

2.99e-0486021032
GeneFamilyCD molecules|Integrin alpha subunits

ITGAD ITGAL

1.60e-03186021160
GeneFamilyImmunoglobulin like domain containing|Semaphorins

SEMA3C SEMA3G

1.98e-0320602736
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

FANCI FANCM

1.98e-0320602548
GeneFamilySerpin peptidase inhibitors

SERPINA11 SERPINB6

6.69e-0337602739
CoexpressionMULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP

PPARGC1A CACNA2D1 UGGT1 GPR137B STAG2 TFDP2

2.74e-06130796M6590
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

KNTC1 PPARGC1A FAP SEMA3C SACS MYO9A SCAF11 TRPM1 STAG2 KIF20B

2.74e-056567910M18979
CoexpressionGSE360_CTRL_VS_B_MALAYI_HIGH_DOSE_MAC_DN

CUL1 VWF SACS ITGAL HNRNPL SBNO2

3.20e-05200796M5167
CoexpressionPUJANA_BRCA2_PCC_NETWORK

KNTC1 CCNE2 FANCI PTPN22 HNRNPUL1 STAG2 KIF20B TFDP2

4.34e-05426798M9516
CoexpressionPEART_HDAC_PROLIFERATION_CLUSTER_DN

CUL1 KNTC1 CCNE2 TFDP2

6.37e-0571794M1421
CoexpressionYANG_BCL3_TARGETS_UP

ACSL3 KNTC1 PPARGC1A CCNE2 CENPI PEX12 KIF20B

6.64e-05333797M2424
CoexpressionMULLIGHAN_NPM1_SIGNATURE_3_UP

PPARGC1A CACNA2D1 UGGT1 CENPI GPR137B STAG2 TFDP2

6.90e-05335797M10277
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AGBL4 KNTC1 CCNE2 FANCI CENPI KIF20B FRMD5

3.32e-08180797f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AGBL4 KNTC1 CCNE2 FANCI CENPI FRMD5

7.97e-0717979680112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KNTC1 SEMA3C CCNE2 FANCI ATRNL1 NDST4

1.24e-06193796bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

AGBL4 CENPI PTPN22 HERC1 ITGAL

8.88e-06157795a633fb8e7a009490c6002bf272eceaf317f27af6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 CCNE2 FANCI CENPI KIF20B

1.20e-0516779550c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCNE2 FANCI CENPI NDST2 KIF20B

1.20e-05167795bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TSGA13 CCNE2 FANCI CENPI KIF20B

1.23e-05168795d35944fd9fea9934ce1e76b2b35d48e2300cca61
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACSL3 KNTC1 AIFM2 CENPI KIF20B

1.23e-051687954c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PPARGC1A ST6GAL2 CACNA2D1 LAMA4 PDZD2

1.46e-05174795b7f5492ce8098f7eb0aef30ee558d00738d59d0e
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PPARGC1A ST6GAL2 CACNA2D1 LAMA4 PDZD2

1.46e-0517479571730503be3d9c839c4c9e950145e2101d682a1c
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PPARGC1A ST6GAL2 CACNA2D1 LAMA4 PDZD2

1.46e-05174795ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PPARGC1A ST6GAL2 CACNA2D1 LAMA4 PDZD2

1.46e-05174795cafe4d6b5f08d8888e9db6e196c66df991c03e7b
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1A MYO9A MACF1 SCAF11 HNRNPUL1

1.54e-05176795749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KNTC1 VWF CCNE2 FANCI CENPI

1.63e-05178795462111b61f37338f97ac7dc6c7da1d4316b54445
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 CCNE2 FANCI CENPI KIF20B

1.72e-05180795401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCelldroplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KNTC1 CCNE2 FANCI CENPI KIF20B

1.81e-0518279511494a66d986297b837332ee9d382b71b9f22591
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

VWF FGD5 SEMA3G ECE1 PDZD2

1.91e-051847950f19494789f38ab1a420545e15e748ca7eb345c3
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KNTC1 CCNE2 FANCI CENPI KIF20B

1.96e-0518579547c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SACS FGD5 HNRNPUL1 ECE1

2.01e-051867950ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAP FANCI ATRNL1 CENPI KIF20B

2.07e-05187795e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAP FANCI ATRNL1 CENPI KIF20B

2.07e-05187795cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 CCNE2 FANCI CENPI KIF20B

2.07e-051877959351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 FANCI CENPI ITGAL KIF20B

2.07e-0518779573931a5ea73799095daff100b5f18853c57c74dc
ToppCellPBMC-Mild-cDC_12|Mild / Compartment, Disease Groups and Clusters

KNTC1 CCNE2 FANCI CENPI PRR22

2.17e-05189795946c95d2ecc36b241f58e8c4ad6455fe47c762fa
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPC1 PPARGC1A SEMA3C LAMA4 ADGRV1

2.17e-051897958c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellmoderate-Lymphoid-NK|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CACNA2D1 FAP FKBP9 LAMA4 TRPM1

2.17e-0518979522a19365782003c18ec8dddcdbfdaa82c4e330f6
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPC1 PPARGC1A SEMA3C LAMA4 ADGRV1

2.17e-051897955d902a4660a27548764bf04c6de152b565da835c
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

KNTC1 FANCI CENPI PTPN22 KIF20B

2.29e-05191795bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCellEndothelial-C|World / shred on cell class and cell subclass (v4)

SEMA3C VWF FGD5 SEMA3G ECE1

2.29e-05191795bf203931f973098b79ec681d1dd0854419819e98
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

KNTC1 FANCI CENPI FANCM KIF20B

2.40e-051937954b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KNTC1 SEMA3C CCNE2 FANCI ATRNL1

2.40e-05193795516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

KNTC1 SEMA3C FANCI ATRNL1 CENPI

2.46e-05194795590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCellPND07-Endothelial-Endothelial_blood-vessel|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA3C VWF FGD5 SEMA3G ECE1

2.46e-0519479512496bc964d1c572241410524a89ca1a9fdb7e34
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF MACF1 FGD5 CACHD1 ECE1

2.46e-051947950b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellPND07-Endothelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA3C VWF FGD5 SEMA3G ECE1

2.46e-05194795d1080c86884916c22894b27994141463f5919812
ToppCellPND03-Endothelial-Endothelial_blood-vessel|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA3C VWF FGD5 SEMA3G ECE1

2.46e-05194795f93f5148b136819d87faef89707dbaba07d6c2b5
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KNTC1 CCNE2 FANCI CENPI KIF20B

2.52e-05195795cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell10x5'v1-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

VWF FKBP9 LAMA4 FGD5 SEMA3G

2.52e-0519579522a481927147ec4ae9d59e6af7c87df0e9cb51e4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF LAMA4 FGD5 SEMA3G ECE1

2.52e-051957954658fb197657d7692ee344ae76b11b0210c418ba
ToppCellCOVID-19-kidney-Proliferating_T_cell|kidney / Disease (COVID-19 only), tissue and cell type

FANCI CENPI PTPN22 ITGAL KIF20B

2.52e-051957957e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KNTC1 CCNE2 FANCI CENPI KIF20B

2.52e-05195795b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KNTC1 CCNE2 FANCI CENPI KIF20B

2.52e-0519579556d8734d020b3da08a5aa9e67999706a9e023a99
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 UGGT1 MACF1 SCAF11 HERC1

2.52e-051957957796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF LAMA4 FGD5 SEMA3G ECE1

2.65e-0519779562c0a90869431e582bb7bb329e0b0cc59123d3d1
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KNTC1 CCNE2 FANCI CENPI KIF20B

2.65e-0519779584ed777cdba569200a3ef1654d8a12f17fcfb7f1
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF LAMA4 FGD5 SEMA3G ECE1

2.65e-0519779516f0eb047df9d702518f82ee99c6e7dc1350b2fb
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF LAMA4 FGD5 SEMA3G ECE1

2.72e-05198795218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCellmild_COVID-19_(asymptomatic)-NK|World / disease group, cell group and cell class (v2)

NPC1 MACF1 PTPN22 ITGAL TFDP2

2.72e-051987957a0aac52d785037455e068e1b25de4b2bf0fff79
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF LAMA4 FGD5 SEMA3G ECE1

2.72e-051987957cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

KNTC1 ST6GAL2 FANCI CENPI KIF20B

2.85e-052007954cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

VWF FKBP9 LAMA4 MACF1 ECE1

2.85e-05200795eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PPARGC1A ATRNL1 ELF5 FRMD5 MGAM2

2.85e-05200795030efc36bbb848da31b0db3f74d46aac9c79cc9b
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NDST1 ELF5 ADGRV1 FRMD5 MGAM2

2.85e-052007957c2d499af60654b7b28f172ac2c914ad49fb74b4
ToppCellPSB-critical-LOC-Lymphoid-Treg|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KNTC1 CCNE2 FANCI CENPI KIF20B

2.85e-052007953e3de496508efb2f95e5e8684f97687381e96493
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KNTC1 CCNE2 FANCI CENPI KIF20B

2.85e-05200795af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

RALGAPA1 SERPINB6 VWF FKBP9 ECE1

2.85e-05200795b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PPARGC1A FUT9 SEMA3G ATP8B2

3.04e-0510079460c2bdee5d37dedf9be1e03b6b52b539a2277df3
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PPARGC1A FUT9 SEMA3G ATP8B2

3.16e-05101794de49feca7548640f85d206ebc56a58ab0bf7ac16
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular|TCGA-Stomach / Sample_Type by Project: Shred V9

CENPI ZNF860 KIF20B FRMD5

1.07e-0413879493497c0a5d5e54006653b2dedc7a7041e1a613e6
ToppCellIIH-CD4-CD8_1|IIH / Condition, Cell_class and T cell subcluster

TSGA13 ADGRV1 ECE1 FAM110C

1.29e-04145794296b6b0eea3233d76742ea35252b2f54d4c27ab6
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF790 FUT9 ZNF860 FANCM

1.29e-04145794b17699f7f98d2361a4d26c26f52db05e7ff69dff
ToppCell356C-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SLC22A15 NDST2 PRR22 HNRNPL

1.51e-041517942dc132895609e4efe17954e31f53d9c1ccf256ef
ToppCell356C-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SLC22A15 NDST2 PRR22 HNRNPL

1.51e-0415179422afd8201eff8471da3456be065f2790de5e4bfe
ToppCellCOVID-19_Severe-B_cell|COVID-19_Severe / disease group, cell group and cell class

ZNF860 FAM110C CLEC16A TFDP2

1.58e-04153794701a7d92ee7b22277c8462742a530347cc6f061a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FAP CCNE2 FANCI CENPI

1.67e-04155794969fc4c98a96bf2f436e8e63d4deb2183ef3b864
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAP VWF FGD5 ZNF860

1.71e-04156794ff39712c7a2dc1b85c598d5105789aa291dea726
ToppCellfacs-SCAT-Fat-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINA11 PTPN22 ITGAD ITGAL

1.84e-0415979451bdbacb79227fbee38bb8680c58cb99878df0c7
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAP VWF FGD5 SEMA3G

2.07e-041647943cd80e6275f0f9b5667912139d15ebf5e6b17f2f
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK|Cerebellum / BrainAtlas - Mouse McCarroll V32

SEMA3C VWF FGD5 SEMA3G

2.12e-041657947d319a112b9062efee428bef6f4534d2ce782e04
ToppCellfacs-Heart-LV-3m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KNTC1 PTPN22 ITGAD ITGAL

2.27e-0416879418c266162a879544c0103d9dff0270af68964f9e
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

VWF FGD5 SEMA3G ECE1

2.27e-041687948c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCellfacs-Heart-LV-3m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KNTC1 PTPN22 ITGAD ITGAL

2.27e-04168794cb1506cd43a4f36f9024cc9b8e5319365498d244
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 CCNE2 FANCI CENPI

2.32e-04169794e7514956b2e4298222ec443f98b2f5289451786e
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KNTC1 FANCI CENPI KIF20B

2.32e-04169794e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KNTC1 FAP CCNE2 TRPM1

2.32e-04169794335619507857383c3b0b507cdf05d786ed59e585
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 CCNE2 FANCI CENPI

2.32e-04169794121768fc51fc3441ec725346a1bbe29e21d05971
ToppCellNS-critical-d_0-4-Lymphoid-B_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CUL1 SACS PEX12 KIF20B

2.42e-04171794bd1ebd9037a740ad8c01c460d778b0973d8b56df
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAP FANCI ATRNL1 CENPI

2.42e-04171794b0373ed8283ee1792b6a490bff93906546978593
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KNTC1 CCNE2 FANCI CENPI

2.42e-04171794bf475a69db04d4a886e442704955c6a96ff0de46
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAP FANCI ATRNL1 CENPI

2.42e-04171794b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCellImmune_cells-pro-B|Immune_cells / Lineage and Cell class

CACNA2D1 HNRNPUL1 TFDP2 PDZD2

2.48e-04172794096636f2589fa56d15942aac96641c16fd5fa78d
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GAL2 CACNA2D1 SACS LAMA4

2.53e-04173794cb6389536195443633adb06e5f1b7483530773d1
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Tall_Cell|TCGA-Thryoid / Sample_Type by Project: Shred V9

NPC1 FAP SEMA3C FRMD5

2.53e-041737942e9dc137f3675eee07f941eb4cfcaf24a83ab0fb
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

VWF FGD5 SEMA3G ECE1

2.53e-041737943a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 FANCI CENPI KIF20B

2.59e-0417479484da9faff088d05233183b425385beb054c92d1b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 FANCI CENPI KIF20B

2.59e-041747947b318796728001c17b4043d2b033330c7be40c78
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-ILCP|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SERPINA11 PTPN22 SPATA32 PDZD2

2.59e-041747945e6050d20a5b27640f6a200441125b8ceba123c8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SACS GPR137B ZNF860 KIF20B

2.59e-04174794ebe6ce173ad12d4a2afa39f8d6185c0e4f97fb1e
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D175|Adult / Lineage, Cell type, age group and donor

NLRP11 VWF FGD5 SEMA3G

2.65e-041757940a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|368C / Donor, Lineage, Cell class and subclass (all cells)

CCNE2 CENPI CACHD1 ADGRV1

2.65e-04175794fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 FANCI CENPI KIF20B

2.65e-04175794876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCellNS-moderate-d_07-13-Lymphoid-NK|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CACNA2D1 LAMA4 TRPM1 ATP8B2

2.65e-04175794f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|368C / Donor, Lineage, Cell class and subclass (all cells)

CCNE2 CENPI CACHD1 ADGRV1

2.65e-0417579436c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CUL1 CACNA2D1 CCNE2 MACF1

2.70e-04176794cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF FGD5 SEMA3G ECE1

2.70e-041767941df7b6ce2519ad99bacbbaf1a8d5929e11513faa
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF FGD5 SEMA3G ECE1

2.70e-0417679427e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF FGD5 SEMA3G ECE1

2.70e-04176794d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCell390C-Endothelial_cells-Endothelial-E-|390C / Donor, Lineage, Cell class and subclass (all cells)

VWF FGD5 SEMA3G ECE1

2.82e-04178794804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell390C-Endothelial_cells-Endothelial-E|390C / Donor, Lineage, Cell class and subclass (all cells)

VWF FGD5 SEMA3G ECE1

2.82e-04178794ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 CCNE2 FANCI CENPI

2.88e-0417979488d44b04eb5c079531db663ed98ddb20b60feb9a
DrugHexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; HL60; HG-U133A

ACSL3 MYO9A CCNE2 PEX12 PTPN22 HNRNPUL1 STAG2

4.11e-061937771982_DN
Diseaseazoospermia (implicated_via_orthology)

NDST1 NDST2 NDST4

4.42e-0527753DOID:14227 (implicated_via_orthology)
DiseaseAddison's disease (is_implicated_in)

PTPN22 CLEC16A

6.34e-055752DOID:13774 (is_implicated_in)
Diseasethalamus volume

PPARGC1A MACF1 ADGRV1 CAMTA1

6.67e-0585754EFO_0006935
Diseasered blood cell density measurement

RALGAPA1 PPARGC1A SEMA3C MYO9A FKBP9 FGD5 ADGRV1 CAMTA1 ATP8B2 KIF20B

7.60e-058807510EFO_0007978
Diseaseglucagon measurement, glucose tolerance test

MACF1 HERC1

9.50e-056752EFO_0004307, EFO_0008463
Diseasehearing impairment

SERPINB6 ADGRV1 SLC33A1 STAG2

1.16e-0498754C1384666
Diseasepostcentral gyrus volume measurement

AGBL4 NDST4

2.27e-049752EFO_0010323
Diseasewaist-hip ratio

NPC1 AGBL4 KNTC1 NDST1 SEMA3C AIFM2 LAMA4 TBX10 CUL9 ECE1 CLEC16A

2.60e-0412267511EFO_0004343
Diseaserenal fibrosis (biomarker_via_orthology)

PPARGC1A ECE1

4.14e-0412752DOID:0050855 (biomarker_via_orthology)
Diseasecortical thickness

AGBL4 CUL9 MACF1 USP35 ADGRV1 CAMTA1 ECE1 KIF20B TFDP2 PDZD2

5.02e-0411137510EFO_0004840
Diseasecortical surface area measurement

CACNA2D1 SEMA3C GPR137B CUL9 MACF1 CACHD1 USP35 ADGRV1 KIF20B TFDP2 PDZD2

5.68e-0413457511EFO_0010736
Diseaseautism spectrum disorder (implicated_via_orthology)

NDST1 NDST2 NDST4 SCAMP2

6.19e-04152754DOID:0060041 (implicated_via_orthology)
DiseaseMYELODYSPLASTIC SYNDROME

FANCI FANCM STAG2

6.72e-0467753C3463824
DiseaseHuntington's disease (biomarker_via_orthology)

PPARGC1A DRD1

7.48e-0416752DOID:12858 (biomarker_via_orthology)
DiseaseCongenital Intestinal Aganglionosis

SEMA3C ECE1

8.46e-0417752C3661523
Diseaseintellectual disability (implicated_via_orthology)

NDST1 NDST2 NDST4

9.34e-0475753DOID:1059 (implicated_via_orthology)
Diseaseankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis

FAP PTPN22 ITGAL CLEC16A SBNO2

9.41e-04295755EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268
DiseaseBone marrow hypocellularity

FANCI FANCM

9.50e-0418752C1855710
Diseaseovulation

GCM2 FANCI

1.06e-0319752GO_0030728
Diseasehyperglycemia (biomarker_via_orthology)

PPARGC1A DRD1

1.30e-0321752DOID:4195 (biomarker_via_orthology)
Diseasesystemic scleroderma (is_implicated_in)

PTPN22 HNRNPL

1.70e-0324752DOID:418 (is_implicated_in)
Diseasenephrotic syndrome (biomarker_via_orthology)

PPARGC1A ECE1

1.70e-0324752DOID:1184 (biomarker_via_orthology)
DiseaseFanconi Anemia

FANCI FANCM

1.84e-0325752C0015625
Diseaseupper face morphology measurement

GPR137B MACF1 ADGRV1

1.96e-0397753EFO_0010949
DiseasePancytopenia

FANCI FANCM

1.99e-0326752C0030312
Diseasemethionine measurement

GPR137B ADGRV1

1.99e-0326752EFO_0009771
DiseaseAcute monocytic leukemia

FANCI FANCM

1.99e-0326752C0023465
DiseaseVitiligo

FAP SERPINB6 PTPN22

2.20e-03101753EFO_0004208
Diseaseimmune system disease

PTPN22 TRPM1

2.31e-0328752EFO_0000540
Diseaserevision of total joint arthroplasty

CAMTA1 FRMD5

2.31e-0328752EFO_0020974
Diseasecorpus callosum central volume measurement

CLEC16A PDZD2

2.31e-0328752EFO_0010296
DiseaseMiller Dieker syndrome

FANCI FANCM

2.48e-0329752C0265219

Protein segments in the cluster

PeptideGeneStartEntry
SKNVSYTDQAFFSFV

SLC33A1

101

O00400
FSAIDSNKDYTSSFS

CAMTA1

586

Q9Y6Y1
SSFRYFQSVDFAAVN

ADGRV1

3491

Q8WXG9
TSDFSRFTNYRFKNL

CCNE2

81

O96020
NSFSDRTVQRFYKFN

CACHD1

891

Q5VU97
YAFNADFRKAFSTLL

DRD1

331

P21728
RTQGYSFFNDAEESK

ELF5

126

Q9UKW6
ASDYSFSQFKFLQRL

ATP8B2

861

P98198
KYKNSEINFSFSRSF

PPM1K

351

Q8N3J5
SEASAFYSLNSFDSK

IRX4

91

P78413
TSFDFLELNYSFDKN

PTPN22

376

Q9Y2R2
YNFSISSFSKNRFED

FANCI

756

Q9NVI1
LFTAEYQTSNRFHFK

MGAM2

126

Q2M2H8
EIYFNSFFKDRQRAS

NLRP11

306

P59045
YNSFNDEKSVSSNLF

FANCM

946

Q8IYD8
KNFFSTKTDYFNETT

FUT9

51

Q9Y231
NSSYSFESDFDLTKS

HERC1

1571

Q15751
NKNFLSNYSRNFSSF

PDZD2

1516

O15018
TLFYSFKAEDTNSAQ

FGD5

1436

Q6ZNL6
FRESKLTHYFQSFFN

KIF20B

431

Q96Q89
SSFDEILAFYNDASK

KCNS2

146

Q9ULS6
SNTTSDFYFEKSANY

NDST1

666

P52848
NFEVFLSFEDYSNSS

KNTC1

996

P50748
SNTTSDFLFEKSANY

NDST4

656

Q9H3R1
TAYFQFFSDARELES

MACF1

786

Q9UPN3
SRQEESTKYFNFATS

ITGAD

926

Q13349
QASESCLFRFFKNSY

NPC1

811

O15118
FFKSNYADLDSNSDD

PPARGC1A

756

Q9UBK2
FDSSYDRDSTFNVFV

FKBP9

71

O95302
SSSNLFFKGSRFRYS

FRMD5

306

Q7Z6J6
TEQTQYFFDNDSKSF

CACNA2D1

976

P54289
YFFDNDSKSFSGVLD

CACNA2D1

981

P54289
SFESQFLADTERFYT

CUL1

231

Q13616
QNAEDFSYSSTSFNR

AGBL4

361

Q5VU57
FSYSSTSFNRDAVKA

AGBL4

366

Q5VU57
RDSFSYEKFNFRSNP

ATRNL1

1186

Q5VV63
SCSYKDFSESRNNRF

HNRNPL

471

P14866
DALDRFSSFYSQSQN

CUL9

1726

Q8IWT3
FFSVYVSADSKNSNS

ECE1

236

P42892
TKSEFNFSSKTYQEF

CENPI

626

Q92674
SRYSAALAESDTFFQ

FAM110C

206

Q1W6H9
NRSYKVSAASSFFFS

SLC22A15

106

Q8IZD6
QSYKRKSEQEFSFDT

SCAF11

1121

Q99590
STSASRFQSDKYSFQ

SACS

4381

Q9NZJ4
AFTQSRAASYFFDGS

LAMA4

1041

Q16363
STNSRFENYGDKFAE

HNRNPUL1

311

Q9BUJ2
FSFYFKDFVAANSLS

GPR137B

96

O60478
FSTFNDYAFLTAEEK

RSPRY1

491

Q96DX4
YFFFKEKLTDNNRST

SEMA3C

241

Q99985
FISYSVTFKDNFRQG

AIFM2

66

Q9BRQ8
SYSSYERSFDFTNKQ

GCM2

316

O75603
SQEDKNFAQSYFDFS

SPATA32

311

Q96LK8
DFLSSFRDSCQKFYQ

SERPINB6

101

P35237
FFSSQVGRKSQSAFY

ST6GAL2

111

Q96JF0
IYKAFRSDNSFSFFV

SCAMP2

206

O15127
FAQDSSYFEDFSNIS

SBNO2

91

Q9Y2G9
FESQLSLNFYTNAKF

TECTB

151

Q96PL2
VQFSTSYKTEFDFSD

ITGAL

196

P20701
SRTSASFSENFYGLK

PEX12

76

O00623
ISSDKFEYLFNFDNT

TFDP2

291

Q14188
FYFFSESRQEKSNRI

ACSL3

41

O95573
TNDFALYTEAIKFFN

CLEC16A

166

Q2KHT3
FRVTQDSLFYSSNEF

FAP

401

Q12884
DSERYAQENFKSFIF

TBX10

206

O75333
LDTVSNVDYFFNFKA

PRR22

346

Q8IZ63
FRFSTDNDFKSEGKY

TSGA13

176

Q96PP4
SDSFSAFQYDGRKFD

RALGAPA1

911

Q6GYQ0
TGQSHFKSFDNRYFT

VWF

391

P04275
FSRYQTQKQESFFVD

SERPINA11

221

Q86U17
YNFDRSSSTFSGIKE

STAG2

936

Q8N3U4
YLFNDTRVSFSSFES

USP35

891

Q9P2H5
NASTDFLFEKSATYF

NDST2

666

P52849
FRTYDDFSYQTSKEN

TRPM1

766

Q7Z4N2
SYEFKDFEKAFSSSS

ZNF790

616

Q6PG37
SDQDNDKVYFFFSET

SEMA3G

236

Q9NS98
FDEAFSQASSYAKQR

ZNF860

571

A6NHJ4
FSIRDYFTFASTFEN

WDR24

171

Q96S15
KAFNSSSSFRYHERT

ZNF433

401

Q8N7K0
ASNNFFVDDYARFTI

UGGT1

711

Q9NYU2
SSSYFRDLFNNSRSA

NACC1

51

Q96RE7
ALKEFRQNIFSFYSS

MYO9A

1896

B2RTY4