Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	BNIP2 TBC1D4 ABR TAGAP SGSM2 DENND4B DOCK7 ARHGAP30 HERC1 RGL2 SH3BP5 SOS2	2.86e-06	507	90	12	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	BNIP2 TBC1D4 ABR TAGAP SGSM2 DENND4B DOCK7 ARHGAP30 HERC1 RGL2 SH3BP5 SOS2	2.86e-06	507	90	12	GO:0030695
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	ABR TAGAP DENND4B DOCK7 HERC1 RGL2 SH3BP5 SOS2	9.75e-06	231	90	8	GO:0005085
Domain	MRFAP1	MRFAP1 MRFAP1L1	2.30e-05	2	90	2	IPR029254
Domain	FAM219	FAM219B FAM219A	2.30e-05	2	90	2	IPR029339
Domain	FAM219A	FAM219B FAM219A	2.30e-05	2	90	2	PF15260
Domain	MRFAP1	MRFAP1 MRFAP1L1	2.30e-05	2	90	2	PF15155
Domain	BNIP2	PRUNE2 BNIP2	1.37e-04	4	90	2	PF12496
Domain	Bcl2-/adenovirus-E1B	PRUNE2 BNIP2	1.37e-04	4	90	2	IPR022181
Domain	Znf_C2H2_matrin	CIZ1 ZNF638	1.47e-03	12	90	2	IPR000690
Domain	CRAL_TRIO_2	PRUNE2 BNIP2	1.47e-03	12	90	2	PF13716
Domain	WD40	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	1.58e-03	259	90	6	PF00400
Domain	WD40	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	1.88e-03	268	90	6	SM00320
Domain	Ras_G-nucl-exch_fac_CS	RGL2 SOS2	2.01e-03	14	90	2	IPR019804
Domain	WD40_repeat	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	2.02e-03	272	90	6	IPR001680
Domain	WD_REPEATS_1	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	2.26e-03	278	90	6	PS00678
Domain	WD_REPEATS_2	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	2.30e-03	279	90	6	PS50082
Domain	WD_REPEATS_REGION	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	2.30e-03	279	90	6	PS50294
Domain	WD40_repeat_dom	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	3.13e-03	297	90	6	IPR017986
Domain	RhoGAP	ABR TAGAP ARHGAP30	3.33e-03	62	90	3	SM00324
Domain	ZF_MATRIN	CIZ1 ZNF638	3.34e-03	18	90	2	PS50171
Domain	RhoGAP	ABR TAGAP ARHGAP30	3.49e-03	63	90	3	PF00620
Domain	RHOGAP	ABR TAGAP ARHGAP30	3.65e-03	64	90	3	PS50238
Domain	RhoGAP_dom	ABR TAGAP ARHGAP30	3.65e-03	64	90	3	IPR000198
Domain	-	ABR TAGAP ARHGAP30	3.65e-03	64	90	3	1.10.555.10
Domain	RasGEFN	RGL2 SOS2	4.12e-03	20	90	2	SM00229
Domain	CARBOXYPEPT_ZN_1	AEBP1 AGBL1	4.12e-03	20	90	2	PS00132
Domain	RNaseH-like_dom	EXOSC10 REV3L PRPF8	4.51e-03	69	90	3	IPR012337
Domain	RasGEF_N	RGL2 SOS2	4.54e-03	21	90	2	PF00618
Domain	CRAL_TRIO	PRUNE2 BNIP2	4.54e-03	21	90	2	PF00650
Domain	Ras-like_Gua-exchang_fac_N	RGL2 SOS2	4.98e-03	22	90	2	IPR000651
Domain	Znf_C2H2_jaz	CIZ1 ZNF638	4.98e-03	22	90	2	IPR022755
Domain	zf-C2H2_jaz	CIZ1 ZNF638	4.98e-03	22	90	2	PF12171
Domain	RASGEF_NTER	RGL2 SOS2	4.98e-03	22	90	2	PS50212
Domain	Peptidase_M14	AEBP1 AGBL1	5.44e-03	23	90	2	PF00246
Domain	-	PRUNE2 BNIP2	5.44e-03	23	90	2	3.40.525.10
Domain	Spectrin	SPTAN1 SYNE2	5.44e-03	23	90	2	PF00435
Domain	Peptidase_M14	AEBP1 AGBL1	5.44e-03	23	90	2	IPR000834
Domain	-	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	5.46e-03	333	90	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	5.61e-03	335	90	6	IPR015943
Domain	WHTH_DNA-bd_dom	FOXO3 ORC1 SPIB SMARCC1 RAD21	6.31e-03	242	90	5	IPR011991
Domain	SEC14	PRUNE2 BNIP2	6.41e-03	25	90	2	SM00516
Domain	RASGEF	RGL2 SOS2	6.92e-03	26	90	2	PS00720
Domain	-	ENTHD1 STAM	6.92e-03	26	90	2	1.25.40.90
Domain	CRAL_TRIO	PRUNE2 BNIP2	7.45e-03	27	90	2	PS50191
Domain	CRAL-TRIO_dom	PRUNE2 BNIP2	8.00e-03	28	90	2	IPR001251
Domain	WD40_repeat_CS	TRAF7 COPA HERC1 CFAP44	8.16e-03	164	90	4	IPR019775
Domain	ZnF_U1	CIZ1 ZNF638	8.57e-03	29	90	2	SM00451
Domain	Znf_U1	CIZ1 ZNF638	8.57e-03	29	90	2	IPR003604
Domain	RASGEF_CAT	RGL2 SOS2	8.57e-03	29	90	2	PS50009
Domain	ENTH_VHS	ENTHD1 STAM	8.57e-03	29	90	2	IPR008942
Domain	Spectrin_repeat	SPTAN1 SYNE2	8.57e-03	29	90	2	IPR002017
Domain	Rho_GTPase_activation_prot	ABR TAGAP ARHGAP30	8.84e-03	88	90	3	IPR008936
Domain	RasGEF	RGL2 SOS2	9.15e-03	30	90	2	PF00617
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FOCAD FRMPD4 SUGP2 SGSM2 DENND4B PPM1E DOCK7 PPIP5K1 RAB11FIP4 FHIP1B	1.19e-07	407	91	10	12693553
Pubmed	Human transcription factor protein interaction networks.	TCF3 COPA SUGP2 ACTR5 SPTAN1 SYNE2 BCL7C GMEB1 ZNF638 ZMYM2 SMARCC1 MECOM MCCC2 HERC1 RHOT1 TCEAL1 RAD21	1.59e-07	1429	91	17	35140242
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOCAD FOXO3 TRAF7 ORC1 DGCR2 ABR SUGP2 ADAMTS7 SGSM2 REV3L HERC1 FHIP1B RGL2 ANO8 AHNAK2	1.77e-07	1105	91	15	35748872
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FOCAD COPA CIAO3 SGSM2 MRFAP1 SPTAN1 ZMYM2 ASTN1 RAB11FIP4 STAM REV3L PRPF8 MRFAP1L1 SH3BP5 SOS2	1.19e-06	1285	91	15	35914814
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EXOSC10 COPA SPTAN1 ZNF638 ZMYM2 PRPF8 AHNAK2 RAD21	2.71e-06	332	91	8	32786267
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	EXOSC10 TBC1D4 COPA ACTR5 ACOT9 SPTAN1 NAF1 SYNE2 ZNF638 SMARCC1 MCCC2 PRPF8 DYNC1I2 AHNAK2 RAD21	3.86e-06	1415	91	15	28515276
Pubmed	Forkhead Box O3a requires BAF57, a subunit of chromatin remodeler SWI/SNF complex for induction of p53 up-regulated modulator of apoptosis (Puma) in a model of Parkinson's disease.	FOXO3 SMARCC1	6.77e-06	2	91	2	31971251
Pubmed	Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B.	FOXO3 FOXO3B	6.77e-06	2	91	2	22588664
Pubmed	Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.	FOXO3 FOXO3B	6.77e-06	2	91	2	9852958
Pubmed	Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation.	TCF3 AEBP1	6.77e-06	2	91	2	9624159
Pubmed	Cleavage of BNIP-2 and BNIP-XL by caspases.	PRUNE2 BNIP2	6.77e-06	2	91	2	17961507
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EXOSC10 COPA SUGP2 SPTAN1 SYNE2 DOCK7 ZNF638 SMARCC1 PRPF8 RAD21	8.34e-06	653	91	10	22586326
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FOXO3 FOXO3B TBC1D4 COPA SUGP2 FBXW5 ZMYM2 SMARCC1 MECOM REV3L PRPF8	1.50e-05	857	91	11	25609649
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	EXOSC10 COPA ACOT9 ZMYM2 SMARCC1 MCCC2 PRPF8 DYNC1I2 RAD21	1.66e-05	560	91	9	35241646
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ABR COPA SUGP2 ACOT9 SPTAN1 DOCK7 SMARCC1 PRPF8 DYNC1I2 AHNAK2	2.03e-05	724	91	10	36232890
Pubmed	A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene.	FOXO3 FOXO3B	2.03e-05	3	91	2	29925039
Pubmed	E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression.	TCF3 SMARCC1	2.03e-05	3	91	2	15016815
Pubmed	Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis.	FOXO3 MECOM	2.03e-05	3	91	2	23509296
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	ABR SPTAN1 DOCK7 ZNF638 SMARCC1 MECOM REV3L PRPF8 DYNC1I2 MRFAP1L1 TCEAL1	2.94e-05	922	91	11	27609421
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ORC1 TCF3 EXOSC10 COPA ACTR5 CIZ1 ZNF638 ZMYM2 SMARCC1 MECOM MCCC2 PRPF8 RAD21	3.19e-05	1294	91	13	30804502
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TBC1D4 COPA SUGP2 SPTAN1 NAF1 BCL7C ZNF638 ZMYM2 SMARCC1 DYNC1I2	3.57e-05	774	91	10	15302935
Pubmed	PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice.	MRFAP1 MRFAP1L1	4.05e-05	4	91	2	15367658
Pubmed	Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain.	MRFAP1 MRFAP1L1	4.05e-05	4	91	2	16407074
Pubmed	Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.	FOXO3 FOXO3B	4.05e-05	4	91	2	9479491
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	EXOSC10 TBC1D4 COPA SUGP2 SPTAN1 SMARCC1 PRPF8 DYNC1I2 RAD21	4.58e-05	638	91	9	33239621
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	ORC1 EXOSC10 COPA SUGP2 MRFAP1 ZNF638 ZMYM2 SMARCC1 MCCC2 PRPF8 RAD21	5.53e-05	989	91	11	36424410
Pubmed	Id3 Maintains Foxp3 Expression in Regulatory T Cells by Controlling a Transcriptional Network of E47, Spi-B, and SOCS3.	TCF3 SPIB	6.74e-05	5	91	2	27974197
Pubmed	CGRP sensory neurons promote tissue healing via neutrophils and macrophages.	SCN10A DOCK7	6.74e-05	5	91	2	38538784
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	EXOSC10 SUGP2 ZNF638 ZMYM2 SMARCC1 RAD21	8.11e-05	271	91	6	32433965
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	ACTR5 SPTAN1 CIZ1 ZNF638 ZMYM2 DYNC1I2 RAD21	8.12e-05	394	91	7	27248496
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	ZNF638 SMARCC1 PRPF8 DYNC1I2 RAD21	8.71e-05	170	91	5	16159877
Pubmed	14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.	FOXO3 ZMYM2	1.01e-04	6	91	2	17389761
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	FOXO3 PRUNE2 TCF3 CDH26 TBC1D4 ABR SUGP2 SGSM2 ZNF638 MCCC2 ANO8 MGRN1 SOS2	1.32e-04	1489	91	13	28611215
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	EXOSC10 COPA SPTAN1 BCL7C ZNF638 PRPF8 SSUH2 RAD21	1.47e-04	582	91	8	20467437
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	TCF3 ABR CIAO3 CIZ1 ZNF638 MECOM DPP3 DYNC1I2 RHOT1 MGRN1	1.55e-04	925	91	10	28986522
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TRAF7 SUGP2 ACTR5 NAF1 BCL7C CIZ1 SMARCC1 MECOM REV3L AGBL1 RHOT1	1.60e-04	1116	91	11	31753913
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PRUNE2 FRMPD4 SUGP2 PPIP5K1	1.65e-04	104	91	4	9205841
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EXOSC10 SUGP2 NAF1 CIZ1 ZNF638 ZMYM2 STAM PRPF8 AHNAK2 RAD21	1.68e-04	934	91	10	33916271
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	FOXO3 CRTC3 TBC1D4 SPTAN1 DOCK7 STAM RAD21	1.74e-04	446	91	7	24255178
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ABR COPA DOCK7 ZNF638 ZMYM2 MCCC2	1.78e-04	313	91	6	38270169
Pubmed	Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.	MECOM NOS2	1.88e-04	8	91	2	22474389
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ORC1 EXOSC10 TBC1D4 COPA SUGP2 SPTAN1 ZNF638 SMARCC1 MCCC2 PRPF8 DYNC1I2 AHNAK2	2.12e-04	1353	91	12	29467282
Pubmed	Molecular characterization of seizure-related genes isolated by differential screening.	DGCR2 REV3L	2.41e-04	9	91	2	8645260
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	COPA ACOT9 SPTAN1 CNTRL MCCC2 DPP3 PRPF8 UNC79 AHNAK2	2.68e-04	807	91	9	30575818
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	EXOSC10 COPA SPTAN1 ZNF638 PRPF8 RAD21	2.77e-04	340	91	6	24332808
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	CRTC3 TBC1D4 ABR SPTAN1 DOCK7 SMARCC1 PRPF8 DYNC1I2	2.77e-04	639	91	8	23443559
Pubmed	Gene mapping of SEZ group genes and determination of pentylenetetrazol susceptible quantitative trait loci in the mouse chromosome.	DGCR2 REV3L	3.01e-04	10	91	2	10700579
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TBC1D4 COPA GMEB1 ZNF638 ZMYM2 STAM SH3BP5	3.61e-04	503	91	7	16964243
Pubmed	Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse.	DOCK7 MGRN1	3.67e-04	11	91	2	8812411
Pubmed	Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.	TCF3 DOCK7 SMARCC1	3.69e-04	53	91	3	21532573
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	EXOSC10 SMARCC1 PPIP5K1 HERC1 PRPF8	3.84e-04	234	91	5	36243803
Pubmed	Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse.	RAB11FIP4 RHOT1	5.18e-04	13	91	2	12696059
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	TTBK1 COPA BCL7C FBXW5 DOCK7	5.87e-04	257	91	5	30945288
Pubmed	A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells.	BCL7C SMARCC1	6.04e-04	14	91	2	30510198
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EXOSC10 SUGP2 SPTAN1 CIZ1 DOCK7 SMARCC1 MCCC2	6.07e-04	549	91	7	38280479
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	COPA DOCK7 SMARCC1 PRPF8 AHNAK2	6.08e-04	259	91	5	31162944
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ABR COPA TAGAP ACOT9 DOCK7 ZMYM2 SMARCC1 ARHGAP30 SOS2	6.68e-04	916	91	9	32203420
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	SPTAN1 PPM1E SH3BP5 RAD21	6.81e-04	151	91	4	17043677
Pubmed	Essential role of MESP1-RING1A complex in cardiac differentiation.	TCF3 RAD21	6.95e-04	15	91	2	36413948
Pubmed	Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.	COPA MRFAP1 SPTAN1 PRPF8 MRFAP1L1	7.46e-04	271	91	5	26816005
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	TRAF7 SYNE2 ZMYM2 FHIP1B AAGAB RGL2 DYNC1I2 RHOT1	7.94e-04	750	91	8	11230166
Pubmed	Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.	SPTAN1 CNTRL SOS2	8.01e-04	69	91	3	32238831
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	COPA SPTAN1 CNTRL SYNE2 ZNF638 SMARCC1 ASTN1 PRPF8	8.22e-04	754	91	8	35906200
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	TRAF7 CRTC3 TCF3 SUGP2 ACOT9 CNTRL IL17RA DYNC1I2	8.22e-04	754	91	8	33060197
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ORC1 COPA ACOT9 CIZ1 ZMYM2 SMARCC1 PRPF8 DYNC1I2 ANAPC13 RAD21	8.84e-04	1155	91	10	20360068
Pubmed	Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.	ANAPC13 RAD21	8.98e-04	17	91	2	21043528
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PRUNE2 CRTC3 AEBP1 SCN10A MGRN1 SOS2	9.49e-04	430	91	6	35044719
Pubmed	YY1 functions with INO80 to activate transcription.	TCF3 ACTR5	1.01e-03	18	91	2	17721549
Pubmed	Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.	BCL7C SMARCC1	1.12e-03	19	91	2	25066234
Pubmed	BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.	BCL7C SMARCC1	1.12e-03	19	91	2	18809673
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	CRTC3 TCF3 SUGP2 MECOM	1.31e-03	180	91	4	35198878
Pubmed	Immunomic analysis of human sarcoma.	TBC1D4 ACTR5	1.38e-03	21	91	2	12601173
Pubmed	The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.	SUGP2 ANAPC13 RAD21	1.42e-03	84	91	3	26299517
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PRUNE2 CRTC3 BNIP2 TBC1D4 COPA SPTAN1 NAF1 DPP3 HERC1 DYNC1I2 AHNAK2	1.46e-03	1455	91	11	22863883
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	FOXO3 CRTC3 TCF3 COPA NAF1 FBXW5 DOCK7 AAGAB SH3BP5	1.60e-03	1038	91	9	26673895
Pubmed	Diversity and specialization of mammalian SWI/SNF complexes.	BCL7C SMARCC1	1.65e-03	23	91	2	8804307
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPN5 TBC1D4 COPA SPTAN1 SYNE2 PPM1E ZNF638 STAM HERC1	1.72e-03	1049	91	9	27880917
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	ABR MRFAP1 MRFAP1L1	1.73e-03	90	91	3	15033168
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	ORC1 ABR SMARCC1 RGL2 SOS2	1.76e-03	329	91	5	17474147
Pubmed	A human MAP kinase interactome.	CRTC3 SPTAN1 CNTRL ZMYM2 RGL2 SOS2	1.77e-03	486	91	6	20936779
Pubmed	SWI/SNF chromatin remodeling and cancer.	BCL7C SMARCC1	1.80e-03	24	91	2	11790558
Pubmed	Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.	BCL7C SMARCC1	1.80e-03	24	91	2	10078207
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	COPA PRPF8	1.80e-03	24	91	2	33705438
Pubmed	Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.	TCF3 BNIP2	1.80e-03	24	91	2	15923648
Pubmed	The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.	BCL7C SMARCC1	1.80e-03	24	91	2	12215535
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	SPTAN1 SYNE2 MCCC2 REV3L	1.82e-03	197	91	4	20811636
Pubmed	Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.	EXOSC10 COPA SPTAN1 DOCK7 PRPF8	1.88e-03	334	91	5	30425250
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FOXO3 CRTC3 TBC1D4 SPTAN1 SYNE2 DOCK7 RGL2 AHNAK2	1.90e-03	861	91	8	36931259
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTAN1 SOS2	1.95e-03	25	91	2	8493579
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	EXOSC10 BNIP2 TBC1D4 MRFAP1 SYNE2 MRFAP1L1	1.98e-03	497	91	6	23414517
Pubmed	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	CRTC3 TAGAP ARHGAP30 REV3L NOS2	2.08e-03	342	91	5	23128233
Pubmed	Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.	BCL7C SMARCC1	2.11e-03	26	91	2	10778858
Pubmed	Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.	SYNE2 SHCBP1L	2.11e-03	26	91	2	25820252
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	EXOSC10 COPA SUGP2 SPTAN1 DOCK7 ZNF638 ZMYM2 SMARCC1 PRPF8	2.12e-03	1082	91	9	38697112
Pubmed	Affinity purification strategies for proteomic analysis of transcription factor complexes.	SMARCC1 PRPF8 RAD21	2.14e-03	97	91	3	23937658
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ORC1 TBC1D4 COPA DOCK7	2.21e-03	208	91	4	33230847
Pubmed	Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.	BCL7C SMARCC1	2.28e-03	27	91	2	29374058
Pubmed	REST repression of neuronal genes requires components of the hSWI.SNF complex.	BCL7C SMARCC1	2.45e-03	28	91	2	12192000
Pubmed	PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.	COPA SUGP2 PRPF8 RAD21	2.58e-03	217	91	4	31685992
GeneFamily	WD repeat domain containing	TRAF7 COPA FBXW5 HERC1 CFAP44 DYNC1I2	1.55e-04	262	56	6	362
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	PRUNE2 BNIP2	1.96e-04	7	56	2	1299
Coexpression	GSE360_CTRL_VS_M_TUBERCULOSIS_DC_UP	FOXO3 SUGP2 SGSM2 SPTAN1 KXD1 ZMYM2 ASTN1	6.38e-06	200	91	7	M5154
Coexpression	GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_UP	FOXO3 ABR STAM REV3L RGL2 TCEAL1 MGRN1	6.38e-06	200	91	7	M6836
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8\|TCGA-Bladder / Sample_Type by Project: Shred V9	CDH26 MECOM MCCC2 FAM219B RGL2	1.38e-05	149	91	5	89705865e94360c1288ee98c5a6b381f3c6242b3
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBC1D4 ACTR5 FBXW5 ZMYM2 PRPF8	1.38e-05	149	91	5	65778f19599b4955c0a16f0121237656449431fb
ToppCell	normal_Lymph_Node-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	NRGN TAGAP NAF1 ZMYM2 FHIP1B	1.38e-05	149	91	5	a34d095b8e0fe59d69d84e4fd2fe4ccb82f92e4f
ToppCell	facs-Trachea-nan-3m-Myeloid-lymphocyte_of_B_lineage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPIB CIAO3 GAPT ARHGAP30 AGBL1	1.77e-05	157	91	5	0fecc14959c4c9efc19d5c06475a890e0a30f148
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 CDH26 MAMSTR MECOM FAM219B	3.24e-05	178	91	5	9f59a9af232d77bb55603a7776dbf9749ea652f2
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DGCR2 TBC1D4 SYNE2 ZNF638 MRFAP1L1	3.79e-05	184	91	5	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	10x5'-blood-Lymphocytic_T_CD4-Tregs\|blood / Manually curated celltypes from each tissue	TBC1D4 SPTAN1 SYNE2 STAM RAD21	3.79e-05	184	91	5	22c15ce30171c687ab564f4383ae74d38b759272
ToppCell	healthy_donor-Lymphocytic-Dendritic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	TBC1D4 SPIB AEBP1 GAPT AHNAK2	3.99e-05	186	91	5	916f2aeea4989ba7a29e071e348a51010f010223
ToppCell	healthy_donor-Lymphocytic-Dendritic-pDC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	TBC1D4 SPIB AEBP1 GAPT AHNAK2	3.99e-05	186	91	5	45f66619e45d590c7365a51782d4ac46b7d31fde
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RHBDL3 MECOM NOS2 FAM219A SSUH2	4.09e-05	187	91	5	25efb82afe863a853ecdd781ad89026c993aaa67
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TCF3 SPIB TAGAP GAPT ARHGAP30	4.31e-05	189	91	5	a12ca69eebc88725272c89d71a57fc6ce0c06813
ToppCell	COPD-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TBC1D4 ACOT9 SYNE2 STAM DYNC1I2	4.53e-05	191	91	5	3ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF3 SPIB ADAMTS7 CNTRL SMARCC1	4.87e-05	194	91	5	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TTBK1 PLIN5 SCN10A IL17RA AGBL1	4.99e-05	195	91	5	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TTBK1 PLIN5 SCN10A IL17RA AGBL1	4.99e-05	195	91	5	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBC1D4 ACOT9 SPTAN1 SYNE2 FBXW5	5.24e-05	197	91	5	7c9df6025b9d168bd6d041c6cff1e87e08b11847
ToppCell	10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-pre_B_progenitor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TCF3 SPIB AEBP1 SYNE2 RAD21	5.50e-05	199	91	5	dadee9fc6ce4f4bdb19d29326889316443dda0cb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Neuronal-Intermediate\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	NRGN RHBDL3 MECOM BCAN IL17RA	5.63e-05	200	91	5	401d50fa394fa863fa7836344110ae5c7af3250a
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Cortical_neuron\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	EXOSC10 ABR ADAMTS7 SPTAN1 RAB11FIP4	5.63e-05	200	91	5	7bba2ff09349c8db3d1ccf53520b12cbf7b0abac
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 SYNE2 MECOM BCAN SSUH2	5.63e-05	200	91	5	77ae679c35d3b9e2b620f34129f3a8d47e922c65
Drug	Niacin [59-67-6]; Down 200; 32.4uM; PC3; HT_HG-U133A	SGSM2 SPTAN1 CNTRL SCN10A GMEB1 ZMYM2 IL17RA SOS2	1.35e-06	199	91	8	6702_DN
Disease	dermoid cyst of ovary (implicated_via_orthology)	FOXO3 FOXO3B	8.59e-06	2	87	2	DOID:5117 (implicated_via_orthology)
Disease	rotator cuff tear, shoulder impingement syndrome	FRMPD4 ACOT9	5.56e-04	12	87	2	EFO_1001178, EFO_1001250
Disease	Myeloproliferative disease	ZMYM2 MECOM	5.56e-04	12	87	2	C0027022
Disease	Myeloid Leukemia	MECOM RAD21	1.28e-03	18	87	2	C0023470
Disease	Leukemia, Monocytic, Chronic	MECOM RAD21	1.28e-03	18	87	2	C0023466
Disease	alcohol use disorder (implicated_via_orthology)	RHBDL3 CIZ1 SMARCC1 UNC79	2.68e-03	195	87	4	DOID:1574 (implicated_via_orthology)
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	NRGN ACTR5 SYNE2 ENTHD1	2.94e-03	200	87	4	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLADLVFPSPEESEA	ABR	351	Q12979
EESELDDQEEPPFVP	CNTRL	1226	Q7Z7A1
EEPAEILPPARDEEE	SH3BP5	11	O60239
FLSELEPEPREDDVE	AEBP1	41	Q8IUX7
LEALLPEDCNPEEPE	CSRNP2	481	Q9H175
DEIPDDEDLDLIPPK	FAM219B	161	Q5XKK7
VNPLIPESPEEEELF	ACOT9	216	Q9Y305
PETPDLEQLEPSLED	ACTR5	391	Q9H9F9
EEDPAEEDCPELVPI	CBWD5	11	Q5RIA9
DVDFLEDVPLLEDIP	CDR1	6	P51861
EEEEEEEPLPEIFIP	CFAP44	731	Q96MT7
LEEISEPTPDPDFLT	ASTN1	786	O14525
EEEAPELDLPGPVFV	ADAMTS7	1046	Q9UKP4
TTEPPHDLPEEDFED	AGBL1	291	Q96MI9
PVDEALAEELEAPRP	ANO8	1091	Q9HCE9
PEEFHDFDQPLPDLD	RAD21	111	O60216
LIPREPGFFPEDEEE	RAB11FIP4	126	Q86YS3
DDFDPLEAEPPACEL	IRX4	261	P78413
IEDDFLDLDPVPETP	PTPN5	201	P54829
EVLEPEEDFEQFLLP	MRFAP1L1	16	Q96HT8
PDDIPIPAEFELRES	MECOM	71	Q03112
KPDDDILDIPLDDPG	NRGN	11	Q92686
PELFEIPPDLVLEVA	NOS2	316	P35228
PEDPAEAPRTLLEFE	BCAN	421	Q96GW7
TFLDDDPELPLLATP	ENTHD1	241	Q8IYW4
LEPPLPLEEEEAYES	FHIP1B	696	Q8N612
LDEEVFEEPLLPPGT	IL17RA	601	Q96F46
DVTIEPSEEPLFPAD	MCCC2	301	Q9HCC0
IIEIDPAPDPEAEDT	GMEB1	521	Q9Y692
DEEKLSEDVDAPPPL	MGRN1	466	O60291
TVPDLEPVPEDELVF	HERC1	3951	Q15751
DEEEDDDVVAPKPPI	DYNC1I2	171	Q13409
EEDPAEEDCPELVPI	CBWD1	11	Q9BRT8
PPPIAEEIDLLVFDL	FBXW5	436	Q969U6
SFLEEEDEDPIPPST	KXD1	106	Q9BQD3
SEEFPEEVPPRAEEI	RHOT1	26	Q8IXI2
DEIPDDEDLDLIPPK	FAM219A	151	Q8IW50
PSEVPQDEDIYILPD	GAPT	141	Q8N292
SERFPEDGPELEEIL	DPP3	701	Q9NY33
EPEPEPELVEAEAAE	PPM1E	46	Q8WY54
EVEFLLEESPSPPET	PLA2G4E	181	Q3MJ16
AKLLELFEDDSDPPP	ORC1	66	Q13415
DRPEDLDVPPALADF	EXOSC10	226	Q01780
LSPLEVELDPEFEPQ	FOXO3B	96	A0A2Z4LIS9
YEDVAIPLNELPEPE	ANAPC13	26	Q9BS18
EEPVPELLEAEAPEA	BCL7C	166	Q8WUZ0
SPDEEEPIERLSVPD	DOCK7	241	Q96N67
DTPFPLEEELQIEPL	CRTC3	576	Q6UUV7
ETFDPEKETIPDIDP	COPA	776	P53621
LPPPEGDDNEDDFLL	FRMPD4	786	Q14CM0
EEDPAEEDCPELVPI	CBWD3	11	Q5JTY5
EEDPAEEDCPELVPI	CBWD6	11	Q4V339
QDEDFPIPLPEDDSI	BNIP2	11	Q12982
PIPLPEDDSIEADIL	BNIP2	16	Q12982
DDDAFEPVEVSLPAP	DGCR2	466	P98153
DDILEDQVEPDDPLP	MAMSTR	311	Q6ZN01
EPLHIEAEDPDLEPF	CDH26	516	Q8IXH8
EEDNEAFPLPESVPV	DENND4B	221	O75064
PEPLEEIKLEFPEEE	SAMD15	326	Q9P1V8
IRPEIPIPEELDDDE	FOCAD	731	Q5VW36
PQVEEFSVEPPLDDL	ARHGAP30	561	Q7Z6I6
EVLEPEEDFEQFLLP	MRFAP1	16	Q9Y605
LSPLEVELDPEFEPQ	FOXO3	11	O43524
DPPADPTDVLVFLAD	RGL2	231	O15211
LLIERFEIPEPEPTD	SOS2	641	Q07890
FEIPEPEPTDADKLA	SOS2	646	Q07890
LTEPEIDEEPIYEPG	PRUNE2	2136	Q8WUY3
EEAEDPFPEEVFPAV	TAGAP	416	Q8N103
PRLLEPEDVDVVDPD	SYNE2	256	Q8WXH0
EELEPEAEERLPAAP	RHBDL3	21	P58872
VFISVDDLEPPEPQD	SGSM2	656	O43147
AAAAEEPLLPVPEDE	SHCBP1L	86	Q9BZQ2
PVLSEEEDLPLDSPA	SPIB	126	Q01892
SNDVDAEIEDPPIPE	SMARCC1	246	Q92922
FEAESPLAPPTELLE	SSUH2	16	Q9Y2M2
FELVELSPEELPEED	AAGAB	136	Q6PD74
LSPEELPEEDDDFPE	AAGAB	141	Q6PD74
EEPAEILEFPPDDSQ	AHNAK2	5606	Q8IVF2
LEEEGVSLPDLEPAP	CIAO3	281	Q9H6Q4
LPVPRDVLETEDEEP	CIZ1	636	Q9ULV3
LPDDDEEFELPEFVE	PRPF8	371	Q6P2Q9
EEFFPEELLPELLPE	TCEAL1	46	Q15170
TTDEEPEELRPLPEE	TTBK1	566	Q5TCY1
DLEPDPEFDPICALF	REV3L	2311	O60673
ARTSPDEDEDDLLPP	TCF3	526	P15923
PAELIGEPLEDLDPF	SCN10A	71	Q9Y5Y9
EPDPEFEAILDTVDP	SPTAN1	2366	Q13813
EAEFEDEPPPREAEL	SUGP2	871	Q8IX01
TFSLPEEEEEPEPLV	TRAF7	106	Q6Q0C0
EEEEEPEPLVFAEQP	TRAF7	111	Q6Q0C0
ETIEPEPEPAFIDED	STAM	291	Q92783
PDPGEDLADLEVVVP	TBC1D4	246	O60343
PDVPYEPDLDIEIDF	ZMYM2	996	Q9UBW7
EPDLDIEIDFPRAAE	ZMYM2	1001	Q9UBW7
PEPLPDLADLVDEVI	PLIN5	386	Q00G26
IDSFDEEPPLLEELG	YIPF7	106	Q8N8F6
EDPLEVRIYDPEIPT	ZNF638	221	Q14966
LLEDEEDEVPPEPQI	PPIP5K1	41	Q6PFW1
PLPPLRIVESDEEEE	UNC79	1636	Q9P2D8
EPPPEALDFSDDEKE	NAF1	306	Q96HR8