Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Notch binding	JAG2 ATRNL1 DLK2	7.53e-05	27	61	3	GO:0005112
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	HINFP ZNF26 SUV39H1 ZNF283 ZNF629 NFXL1 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	1.00e-04	1459	61	14	GO:0000977
GeneOntologyMolecularFunction	calcium ion binding	JAG2 VIL1 NELL2 FBN1 FBN2 LRP1 DLK2 ADGRE2 PROS1	4.23e-04	749	61	9	GO:0005509
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	FBN1 FBN2	5.94e-04	12	61	2	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	FBN1 FBN2	8.16e-04	14	61	2	GO:0097493
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	HINFP ZNF26 ZNF283 ZNF629 NFXL1 ZNF224 ZNF225 ZNF467 ZKSCAN5 ZNF443 ZNF682 ZNF461	1.02e-03	1412	61	12	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HINFP ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF682 ZNF461	1.23e-03	1244	61	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	HINFP ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF682 ZNF461	1.46e-03	1271	61	11	GO:0000987
GeneOntologyMolecularFunction	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	VIL1 XIAP	2.43e-03	24	61	2	GO:0043027
GeneOntologyMolecularFunction	extracellular matrix structural constituent	FBN1 FBN2 MUC17 LAMA2	2.61e-03	188	61	4	GO:0005201
GeneOntologyMolecularFunction	sulfur compound binding	NELL2 FBN1 ADAMTS3 LRP1 ADGRE2	3.05e-03	323	61	5	GO:1901681
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	5.14e-05	4	61	2	GO:0035583
GeneOntologyBiologicalProcess	regulation of axon extension involved in regeneration	LRP1 TNR	5.14e-05	4	61	2	GO:0048690
GeneOntologyBiologicalProcess	protein linear polyubiquitination	XIAP RBCK1	8.55e-05	5	61	2	GO:0097039
GeneOntologyBiologicalProcess	axon extension involved in regeneration	LRP1 TNR	8.55e-05	5	61	2	GO:0048677
GeneOntologyBiologicalProcess	regulation of sprouting of injured axon	LRP1 TNR	8.55e-05	5	61	2	GO:0048686
GeneOntologyBiologicalProcess	sprouting of injured axon	LRP1 TNR	1.28e-04	6	61	2	GO:0048682
Domain	EGF	JAG2 PCSK5 NELL2 FBN1 FBN2 MALRD1 TENM3 MUC17 ATRNL1 CNTNAP2 LRP1 DLK2 LAMA2 ADGRE2 TEK TNR PROS1 PEAR1	2.63e-20	235	61	18	SM00181
Domain	EGF-like_dom	JAG2 PCSK5 NELL2 FBN1 FBN2 MALRD1 TENM3 MUC17 ATRNL1 CNTNAP2 LRP1 DLK2 LAMA2 ADGRE2 TEK TNR PROS1 PEAR1	7.51e-20	249	61	18	IPR000742
Domain	EGF_1	JAG2 NELL2 FBN1 FBN2 MALRD1 TENM3 MUC17 ATRNL1 CNTNAP2 LRP1 DLK2 LAMA2 ADGRE2 TEK TNR PROS1 PEAR1	3.66e-18	255	61	17	PS00022
Domain	EGF-like_CS	JAG2 NELL2 FBN1 FBN2 MALRD1 TENM3 MUC17 ATRNL1 CNTNAP2 LRP1 DLK2 LAMA2 ADGRE2 TEK TNR PROS1 PEAR1	5.43e-18	261	61	17	IPR013032
Domain	EGF_2	JAG2 NELL2 FBN1 FBN2 MALRD1 TENM3 MUC17 ATRNL1 CNTNAP2 LRP1 DLK2 LAMA2 ADGRE2 TEK TNR PROS1 PEAR1	7.03e-18	265	61	17	PS01186
Domain	EGF_3	JAG2 NELL2 FBN1 FBN2 MALRD1 TENM3 MUC17 ATRNL1 CNTNAP2 LRP1 DLK2 ADGRE2 TEK TNR PROS1 PEAR1	2.90e-17	235	61	16	PS50026
Domain	EGF_Ca-bd_CS	JAG2 NELL2 FBN1 FBN2 LRP1 DLK2 ADGRE2 PROS1	9.27e-10	97	61	8	IPR018097
Domain	EGF_extracell	JAG2 NELL2 TENM3 ATRNL1 DLK2 TEK TNR	9.38e-10	60	61	7	IPR013111
Domain	EGF_2	JAG2 NELL2 TENM3 ATRNL1 DLK2 TEK TNR	9.38e-10	60	61	7	PF07974
Domain	EGF_CA	JAG2 NELL2 FBN1 FBN2 LRP1 DLK2 ADGRE2 PROS1	1.09e-09	99	61	8	PS01187
Domain	ASX_HYDROXYL	JAG2 NELL2 FBN1 FBN2 LRP1 DLK2 ADGRE2 PROS1	1.18e-09	100	61	8	PS00010
Domain	Growth_fac_rcpt_	JAG2 PCSK5 NELL2 FBN1 FBN2 LRP1 ADGRE2 TEK PROS1	1.88e-09	156	61	9	IPR009030
Domain	EGF-type_Asp/Asn_hydroxyl_site	JAG2 NELL2 FBN1 FBN2 LRP1 DLK2 ADGRE2 PROS1	1.89e-09	106	61	8	IPR000152
Domain	EGF_CA	JAG2 NELL2 FBN1 FBN2 LRP1 DLK2 ADGRE2 PROS1	5.80e-09	122	61	8	SM00179
Domain	EGF-like_Ca-bd_dom	JAG2 NELL2 FBN1 FBN2 LRP1 DLK2 ADGRE2 PROS1	6.59e-09	124	61	8	IPR001881
Domain	EGF_CA	JAG2 NELL2 FBN1 FBN2 LRP1 ADGRE2 PROS1	1.22e-08	86	61	7	PF07645
Domain	NHR2	CBFA2T2 RUNX1T1 CBFA2T3	3.31e-08	3	61	3	IPR014896
Domain	NHR2	CBFA2T2 RUNX1T1 CBFA2T3	3.31e-08	3	61	3	PF08788
Domain	CBFA2T1/2/3	CBFA2T2 RUNX1T1 CBFA2T3	3.31e-08	3	61	3	IPR013289
Domain	zf-C2H2_6	ZNF26 ZNF283 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	6.60e-08	314	61	10	PF13912
Domain	TAFH	CBFA2T2 RUNX1T1 CBFA2T3	3.30e-07	5	61	3	SM00549
Domain	TAFH	CBFA2T2 RUNX1T1 CBFA2T3	3.30e-07	5	61	3	PS51119
Domain	TAFH	CBFA2T2 RUNX1T1 CBFA2T3	3.30e-07	5	61	3	PF07531
Domain	TAFH_NHR1	CBFA2T2 RUNX1T1 CBFA2T3	3.30e-07	5	61	3	IPR003894
Domain	ZINC_FINGER_C2H2_2	HINFP ZC3H7A ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	1.02e-06	775	61	13	PS50157
Domain	ZINC_FINGER_C2H2_1	HINFP ZC3H7A ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	1.05e-06	777	61	13	PS00028
Domain	Znf_C2H2-like	HINFP ZC3H7A ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	1.37e-06	796	61	13	IPR015880
Domain	Znf_C2H2	HINFP ZC3H7A ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	1.55e-06	805	61	13	IPR007087
Domain	ZnF_C2H2	HINFP ZC3H7A ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	1.62e-06	808	61	13	SM00355
Domain	-	HINFP ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	1.64e-06	679	61	12	3.30.160.60
Domain	zf-C2H2	HINFP ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	2.03e-06	693	61	12	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	HINFP ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	2.06e-06	694	61	12	IPR013087
Domain	KRAB	ZNF26 ZNF283 ZNF224 ZNF225 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	2.28e-06	358	61	9	PS50805
Domain	KRAB	ZNF26 ZNF283 ZNF224 ZNF225 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	2.28e-06	358	61	9	PF01352
Domain	KRAB	ZNF26 ZNF283 ZNF224 ZNF225 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	2.92e-06	369	61	9	SM00349
Domain	KRAB	ZNF26 ZNF283 ZNF224 ZNF225 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	2.98e-06	370	61	9	IPR001909
Domain	EGF	JAG2 MALRD1 CNTNAP2 LRP1 DLK2 PROS1	3.43e-06	126	61	6	PF00008
Domain	-	PCSK5 CNTNAP2 LAMA2 CUL9 RS1	3.98e-06	73	61	5	2.60.120.260
Domain	Laminin_G_2	NELL2 CNTNAP2 LAMA2 PROS1	8.62e-06	40	61	4	PF02210
Domain	LamG	NELL2 CNTNAP2 LAMA2 PROS1	1.27e-05	44	61	4	SM00282
Domain	Galactose-bd-like	PCSK5 CNTNAP2 LAMA2 CUL9 RS1	1.38e-05	94	61	5	IPR008979
Domain	FBN	FBN1 FBN2	3.14e-05	3	61	2	IPR011398
Domain	Laminin_G	NELL2 CNTNAP2 LAMA2 PROS1	3.83e-05	58	61	4	IPR001791
Domain	zf-MYND	CBFA2T2 RUNX1T1 CBFA2T3	4.23e-05	21	61	3	PF01753
Domain	Znf_MYND	CBFA2T2 RUNX1T1 CBFA2T3	4.88e-05	22	61	3	IPR002893
Domain	ZF_MYND_1	CBFA2T2 RUNX1T1 CBFA2T3	4.88e-05	22	61	3	PS01360
Domain	ZF_MYND_2	CBFA2T2 RUNX1T1 CBFA2T3	4.88e-05	22	61	3	PS50865
Domain	cEGF	FBN1 FBN2 LRP1	8.17e-05	26	61	3	IPR026823
Domain	cEGF	FBN1 FBN2 LRP1	8.17e-05	26	61	3	PF12662
Domain	Znf_RING	TRIM45 NSD2 NFXL1 CUL9 XIAP G2E3 RBCK1	9.00e-05	326	61	7	IPR001841
Domain	hEGF	JAG2 FBN2 DLK2	1.02e-04	28	61	3	PF12661
Domain	EGF_Lam	ATRNL1 LAMA2 PEAR1	2.01e-04	35	61	3	SM00180
Domain	TB	FBN1 FBN2	2.18e-04	7	61	2	PF00683
Domain	LAM_G_DOMAIN	CNTNAP2 LAMA2 PROS1	2.58e-04	38	61	3	PS50025
Domain	Laminin_EGF	ATRNL1 LAMA2 PEAR1	2.58e-04	38	61	3	IPR002049
Domain	-	NELL2 CNTNAP2 LAMA2 PROS1	2.63e-04	95	61	4	2.60.120.200
Domain	-	FBN1 FBN2	2.90e-04	8	61	2	3.90.290.10
Domain	TB	FBN1 FBN2	3.72e-04	9	61	2	PS51364
Domain	TB_dom	FBN1 FBN2	3.72e-04	9	61	2	IPR017878
Domain	RING	TRIM45 NSD2 CUL9 XIAP G2E3 RBCK1	4.72e-04	305	61	6	SM00184
Domain	Laminin_G_1	LAMA2 PROS1	5.66e-04	11	61	2	PF00054
Domain	ConA-like_dom	NELL2 MALRD1 CNTNAP2 LAMA2 PROS1	7.39e-04	219	61	5	IPR013320
Domain	IBR	CUL9 RBCK1	9.31e-04	14	61	2	PF01485
Domain	IBR_dom	CUL9 RBCK1	1.07e-03	15	61	2	IPR002867
Domain	Post-SET_dom	NSD2 SUV39H1	1.22e-03	16	61	2	IPR003616
Domain	PostSET	NSD2 SUV39H1	1.22e-03	16	61	2	SM00508
Domain	POST_SET	NSD2 SUV39H1	1.22e-03	16	61	2	PS50868
Domain	Zinc_finger_PHD-type_CS	NSD2 NFXL1 G2E3	1.25e-03	65	61	3	IPR019786
Domain	VWC_out	JAG2 NELL2	1.73e-03	19	61	2	SM00215
Domain	PLAC	PCSK5 ADAMTS3	1.73e-03	19	61	2	PS50900
Domain	PLAC	PCSK5 ADAMTS3	1.73e-03	19	61	2	IPR010909
Domain	FA58C	CNTNAP2 RS1	2.12e-03	21	61	2	SM00231
Domain	FA58C_3	CNTNAP2 RS1	2.12e-03	21	61	2	PS50022
Domain	FA58C_1	CNTNAP2 RS1	2.12e-03	21	61	2	PS01285
Domain	FA58C_2	CNTNAP2 RS1	2.12e-03	21	61	2	PS01286
Domain	ZF_RING_1	TRIM45 NFXL1 CUL9 XIAP RBCK1	2.59e-03	291	61	5	PS00518
Domain	F5_F8_type_C	CNTNAP2 RS1	2.77e-03	24	61	2	PF00754
Domain	FA58C	CNTNAP2 RS1	2.77e-03	24	61	2	IPR000421
Domain	ZF_RING_2	TRIM45 NFXL1 CUL9 XIAP RBCK1	2.87e-03	298	61	5	PS50089
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	FBN1 FBN2 ATRNL1 LRP1 NFXL1 LAMA2	2.96e-09	71	61	6	33541421
Pubmed	CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.	CBFA2T2 RUNX1T1 CBFA2T3	5.13e-09	3	61	3	9790752
Pubmed	ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.	CBFA2T2 RUNX1T1 CBFA2T3	2.05e-08	4	61	3	16966434
Pubmed	Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins.	CBFA2T2 RUNX1T1 CBFA2T3	2.05e-08	4	61	3	14703694
Pubmed	Regional expression of MTG genes in the developing mouse central nervous system.	CBFA2T2 RUNX1T1 CBFA2T3	5.12e-08	5	61	3	19618476
Pubmed	Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.	CBFA2T2 RUNX1T1 CBFA2T3	5.12e-08	5	61	3	18586123
Pubmed	Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription.	CBFA2T2 RUNX1T1 CBFA2T3	5.12e-08	5	61	3	18039847
Pubmed	Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.	CBFA2T2 RUNX1T1 CBFA2T3	1.02e-07	6	61	3	23251453
Pubmed	The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.	CBFA2T2 RUNX1T1 CBFA2T3	1.79e-07	7	61	3	12242670
Pubmed	PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.	CBFA2T2 RUNX1T1 CBFA2T3	6.11e-07	10	61	3	22498736
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	JAG2 PCSK5 NELL2 FBN1 LRP1	2.11e-06	118	61	5	21078624
Pubmed	Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway.	CBFA2T2 RUNX1T1 CBFA2T3	2.83e-06	16	61	3	25077969
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	3.03e-06	2	61	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	3.03e-06	2	61	2	21851253
Pubmed	KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.	KIF4A KIF4B	3.03e-06	2	61	2	36482480
Pubmed	Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry.	RLN3 RXFP3	3.03e-06	2	61	2	15956730
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	3.03e-06	2	61	2	12429739
Pubmed	Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.	RLN3 RXFP3	3.03e-06	2	61	2	27498038
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	3.03e-06	2	61	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	3.03e-06	2	61	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	3.03e-06	2	61	2	15131124
Pubmed	Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.	KIF4A KIF4B	3.03e-06	2	61	2	31486502
Pubmed	Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach.	RLN3 RXFP3	3.03e-06	2	61	2	37967073
Pubmed	Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.	KIF4A KIF4B	3.03e-06	2	61	2	10773663
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	3.03e-06	2	61	2	12524050
Pubmed	The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.	KIF4A KIF4B	3.03e-06	2	61	2	30081192
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	3.03e-06	2	61	2	20404337
Pubmed	Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus.	KIF4A KIF4B	3.03e-06	2	61	2	31616463
Pubmed	Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.	KIF4A KIF4B	3.03e-06	2	61	2	31067151
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	3.03e-06	2	61	2	8791520
Pubmed	Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages.	KIF4A KIF4B	3.03e-06	2	61	2	28350061
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	3.03e-06	2	61	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	3.03e-06	2	61	2	35419902
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	3.03e-06	2	61	2	8307578
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	3.03e-06	2	61	2	10504303
Pubmed	A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.	RLN3 RXFP3	3.03e-06	2	61	2	27353281
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	3.03e-06	2	61	2	7744963
Pubmed	Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain.	RLN3 RXFP3	3.03e-06	2	61	2	20737598
Pubmed	Cellular motor protein KIF-4 associates with retroviral Gag.	KIF4A KIF4B	3.03e-06	2	61	2	10559369
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	3.03e-06	2	61	2	26408953
Pubmed	The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells.	CBFA2T2 CBFA2T3	3.03e-06	2	61	2	22443175
Pubmed	Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.	KIF4A KIF4B	3.03e-06	2	61	2	24658398
Pubmed	The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.	RLN3 RXFP3	3.03e-06	2	61	2	24615237
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	3.03e-06	2	61	2	18006876
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	3.03e-06	2	61	2	24833718
Pubmed	KIF4 regulates midzone length during cytokinesis.	KIF4A KIF4B	3.03e-06	2	61	2	21565503
Pubmed	The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review.	RLN3 RXFP3	3.03e-06	2	61	2	34537263
Pubmed	Exome sequencing identified new mutations in a Marfan syndrome family.	FBN1 LRP1	3.03e-06	2	61	2	24484584
Pubmed	A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.	KIF4A KIF4B	3.03e-06	2	61	2	7929562
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	3.03e-06	2	61	2	24265020
Pubmed	Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice.	RLN3 RXFP3	3.03e-06	2	61	2	24640572
Pubmed	Viral-mediated delivery of an RXFP3 agonist into brain promotes arousal in mice.	RLN3 RXFP3	3.03e-06	2	61	2	24640570
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	3.03e-06	2	61	2	20529844
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	3.03e-06	2	61	2	25524144
Pubmed	Structural basis for the ATP-induced isomerization of kinesin.	KIF4A KIF4B	3.03e-06	2	61	2	23500491
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	3.03e-06	2	61	2	23133647
Pubmed	ETO-2, a new member of the ETO-family of nuclear proteins.	RUNX1T1 CBFA2T3	3.03e-06	2	61	2	10022820
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	3.03e-06	2	61	2	16407178
Pubmed	The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.	RLN3 RXFP3	3.03e-06	2	61	2	19152634
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	3.03e-06	2	61	2	1852206
Pubmed	Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.	RLN3 RXFP3	3.03e-06	2	61	2	28100033
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	3.03e-06	2	61	2	10359653
Pubmed	Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.	KIF4A KIF4B	3.03e-06	2	61	2	9658142
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	NELL2 FBN2 NSD2 ZNF629 LRP1 CUL9 XIAP KAT2A DCAF16 ZKSCAN5 ZNF461	3.40e-06	1116	61	11	31753913
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF283 ZNF224 ZNF225	5.73e-06	20	61	3	12743021
Pubmed	Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.	CBFA2T2 RUNX1T1	9.07e-06	3	61	2	10675041
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	9.07e-06	3	61	2	10825173
Pubmed	CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions.	RUNX1T1 CBFA2T3	9.07e-06	3	61	2	38243303
Pubmed	Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3).	RLN3 RXFP3	9.07e-06	3	61	2	24641548
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	9.07e-06	3	61	2	30201140
Pubmed	Tumor formation via loss of a molecular motor protein.	KIF4A KIF4B	9.07e-06	3	61	2	16890532
Pubmed	KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.	KIF4A KIF4B	9.07e-06	3	61	2	19158085
Pubmed	Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice.	RLN3 RXFP3	9.07e-06	3	61	2	24681162
Pubmed	Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.	KIF4A KIF4B	9.07e-06	3	61	2	10978527
Pubmed	Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.	RLN3 RXFP3	9.07e-06	3	61	2	22257012
Pubmed	Myeloid translocation genes differentially regulate colorectal cancer programs.	CBFA2T2 CBFA2T3	9.07e-06	3	61	2	27270437
Pubmed	KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.	KIF4A KIF4B	9.07e-06	3	61	2	16630823
Pubmed	CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.	KIF4A KIF4B	9.07e-06	3	61	2	35579738
Pubmed	Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.	RLN3 RXFP3	9.07e-06	3	61	2	14522968
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	9.07e-06	3	61	2	20855508
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	1.81e-05	4	61	2	12429738
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2	1.81e-05	4	61	2	25406291
Pubmed	Failure of human rhombic lip differentiation underlies medulloblastoma formation.	CBFA2T2 CBFA2T3	1.81e-05	4	61	2	36131014
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	1.81e-05	4	61	2	20729550
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2	1.81e-05	4	61	2	25034023
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	1.81e-05	4	61	2	16835936
Pubmed	The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.	CBFA2T2 CBFA2T3	1.81e-05	4	61	2	9447981
Pubmed	Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.	RLN3 RXFP3	1.81e-05	4	61	2	15465925
Pubmed	Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.	KIF4A KIF4B	1.81e-05	4	61	2	18684836
Pubmed	Kif4 Is Essential for Mouse Oocyte Meiosis.	KIF4A KIF4B	1.81e-05	4	61	2	28125646
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	3.02e-05	5	61	2	26601954
Pubmed	Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.	CBFA2T2 RUNX1T1	3.02e-05	5	61	2	16227606
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	3.02e-05	5	61	2	12590922
Pubmed	The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.	RLN3 RXFP3	3.02e-05	5	61	2	18434306
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	3.02e-05	5	61	2	17255108
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	3.02e-05	5	61	2	34411563
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	3.02e-05	5	61	2	23493297
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 FBN2	4.52e-05	6	61	2	7873879
Pubmed	The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells.	CUL9 XIAP	4.52e-05	6	61	2	25028717
Pubmed	Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.	NSD2 SUV39H1	6.32e-05	7	61	2	24101509
Interaction	ZDHHC15 interactions	FBN1 FBN2 ATRNL1 LRP1 NFXL1 LAMA2	1.92e-06	125	60	6	int:ZDHHC15
Interaction	MFAP2 interactions	JAG2 FBN1 FBN2	5.42e-06	12	60	3	int:MFAP2
Interaction	ATN1 interactions	JAG2 HINFP PCSK5 NELL2 CBFA2T2 RUNX1T1	1.95e-05	187	60	6	int:ATN1
Interaction	ZFP41 interactions	NELL2 FBN1 FBN2 LRP1	2.49e-05	57	60	4	int:ZFP41
Interaction	CACNA1A interactions	JAG2 PCSK5 NELL2 CNTNAP2 LRP1	3.26e-05	123	60	5	int:CACNA1A
Interaction	NTN5 interactions	JAG2 FBN1 FBN2	4.86e-05	24	60	3	int:NTN5
Interaction	RLN3 interactions	RLN3 RXFP3	5.21e-05	4	60	2	int:RLN3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	HINFP ZNF26 ZNF283 ZNF629 ZNF224 ZNF225 ZNF467 ZNF763 ZKSCAN5 ZNF443 ZNF682 ZNF461	2.04e-07	718	47	12	28
GeneFamily	Zinc fingers MYND-type	CBFA2T2 RUNX1T1 CBFA2T3	2.12e-05	21	47	3	87
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000	PCSK5 FBN1 FBN2 TENM3 ADAMTS3 ATRNL1 LRP1 LAMA2	2.19e-06	310	59	8	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#3_top-relative-expression-ranked_500	FBN1 FBN2 TENM3 ATRNL1 LRP1	2.25e-05	122	59	5	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k3_500
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_1000	PCSK5 FBN1 FBN2 TENM3 ADAMTS3 ATRNL1 LRP1 LAMA2 KIF4A RUNX1T1	4.56e-05	768	59	10	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_1000
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_k-means-cluster#4_top-relative-expression-ranked_500	FBN1 FBN2 TENM3 ATRNL1 LRP1	5.33e-05	146	59	5	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_k4_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#2_top-relative-expression-ranked_1000	FBN1 FBN2 TENM3 ADAMTS3 ATRNL1 LRP1	9.24e-05	265	59	6	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k2_1000
CoexpressionAtlas	dev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#4_top-relative-expression-ranked_500	FBN1 ADAMTS3 LRP1 LAMA2 RUNX1T1	1.51e-04	182	59	5	gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k4_500
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_500	FBN1 FBN2 TENM3 ADAMTS3 ATRNL1 LRP1 RUNX1T1	1.65e-04	423	59	7	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_500
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_top-relative-expression-ranked_1000	NELL2 FBN1 FBN2 TENM3 ADAMTS3 ATRNL1 LAMA2 TEK TNR	1.79e-04	734	59	9	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_1000
CoexpressionAtlas	dev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000	FBN1 FBN2 TENM3 ADAMTS3 ATRNL1 LRP1 LAMA2 RUNX1T1 PROS1	2.63e-04	773	59	9	gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000	PCSK5 FBN1 FBN2 TENM3 ATRNL1 LRP1 LAMA2 KIF4A RUNX1T1	2.74e-04	777	59	9	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_1000
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500	FBN1 FBN2 TENM3 ATRNL1 LRP1	2.74e-04	207	59	5	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_500
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2 SLCO1C1 LRP1 LAMA2 TNR	2.12e-07	186	61	6	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNMB2 PCSK5 FBN2 TENM3 CNTNAP2 RUNX1T1	2.18e-07	187	61	6	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.40e-07	190	61	6	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.40e-07	190	61	6	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.47e-07	191	61	6	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.47e-07	191	61	6	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.47e-07	191	61	6	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.47e-07	191	61	6	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.47e-07	191	61	6	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.55e-07	192	61	6	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.55e-07	192	61	6	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.55e-07	192	61	6	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.55e-07	192	61	6	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.55e-07	192	61	6	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CFuPNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	PCSK5 NELL2 TENM3 CNTNAP2 RUNX1T1 ZNF467	2.55e-07	192	61	6	a8841ebd879f1c344ab4246fdef77044170f644d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.55e-07	192	61	6	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.63e-07	193	61	6	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.71e-07	194	61	6	e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.79e-07	195	61	6	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 SLCO1C1 TENM3 ATRNL1 LAMA2 RUNX1T1	2.79e-07	195	61	6	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CFuPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PCSK5 NELL2 TENM3 CNTNAP2 RUNX1T1 ZNF467	2.79e-07	195	61	6	574354ef4bcefeb9856b65d19bb92e2cffe5dc7a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.79e-07	195	61	6	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ADAMTS3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.79e-07	195	61	6	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 SLCO1C1 TENM3 ATRNL1 LAMA2 RUNX1T1	2.79e-07	195	61	6	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 FBN1 TENM3 LRP1 LAMA2 RUNX1T1	2.88e-07	196	61	6	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 FBN1 TENM3 LRP1 LAMA2 RUNX1T1	2.88e-07	196	61	6	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FBN1 FBN2 SLCO1C1 LRP1 LAMA2 PEAR1	2.97e-07	197	61	6	2cb1f557ce1400398975de94638126b4522567f3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.97e-07	197	61	6	6d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.97e-07	197	61	6	ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.97e-07	197	61	6	37f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.97e-07	197	61	6	b349f8e96d61a4c296af64711e11fc44459a9413
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	2.97e-07	197	61	6	c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBN1 SLCO1C1 LAMA2 RUNX1T1 PROS1 PEAR1	3.15e-07	199	61	6	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBN1 SLCO1C1 LAMA2 RUNX1T1 PROS1 PEAR1	3.15e-07	199	61	6	9c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell	COVID-19-kidney-Fibroblast-1\|kidney / Disease (COVID-19 only), tissue and cell type	FBN1 TENM3 ATRNL1 LAMA2 RUNX1T1 ADGRE2	3.15e-07	199	61	6	9503646ff1ad248181146ce767e9d12e882ec3bd
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FZD8 FBN1 TENM3 LRP1 LAMA2 RUNX1T1	3.24e-07	200	61	6	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 ATRNL1 LAMA2 RUNX1T1 ADGRE2	2.62e-06	159	61	5	e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 ATRNL1 LAMA2 RUNX1T1 ADGRE2	2.62e-06	159	61	5	2607b562903228274fbd96168ba826782fab0b53
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HINFP CNTNAP2 NFXL1 ZNF443 ZNF461	3.24e-06	166	61	5	60060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HINFP CNTNAP2 NFXL1 ZNF443 ZNF461	3.24e-06	166	61	5	ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HINFP CNTNAP2 NFXL1 ZNF443 ZNF461	3.24e-06	166	61	5	4586d6725403f879fc96f67be579022587ce1906
ToppCell	Endothelial-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	FBN1 TENM3 RUNX1T1 TEK PEAR1	3.54e-06	169	61	5	95c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 ATRNL1 LAMA2 RUNX1T1 PEAR1	3.54e-06	169	61	5	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 PEAR1	3.75e-06	171	61	5	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	Endothelial-B-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	FBN1 TENM3 DLK2 TEK PEAR1	3.75e-06	171	61	5	07ff7059071da83da1d8f266a586573920d75b58
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 PEAR1	3.75e-06	171	61	5	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	JAG2 TRIM45 CNTNAP2 DLK2 KAT2A	3.85e-06	172	61	5	58eaadf12366701103a0d1f133462c9495fedc30
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	JAG2 TRIM45 CNTNAP2 DLK2 KAT2A	3.85e-06	172	61	5	4483073469001770015526303772fd54906c5d68
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	KCNMB2 FBN1 TENM3 LAMA2 RUNX1T1	4.43e-06	177	61	5	cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	KCNMB2 FBN1 TENM3 LAMA2 RUNX1T1	4.43e-06	177	61	5	db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ATRNL1 LRP1 LAMA2 RUNX1T1	5.35e-06	184	61	5	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 ATRNL1 LRP1 LAMA2 RUNX1T1	5.50e-06	185	61	5	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 NSD2 ATRNL1 KIF4A	5.79e-06	187	61	5	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 NSD2 ATRNL1 KIF4A	5.79e-06	187	61	5	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ADAMTS3 LRP1 LAMA2 RUNX1T1	5.94e-06	188	61	5	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	FBN1 ADAMTS3 LRP1 LAMA2 RUNX1T1	5.94e-06	188	61	5	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLCO1C1 LAMA2 RUNX1T1 CBFA2T3 PEAR1	5.94e-06	188	61	5	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 RUNX1T1	6.10e-06	189	61	5	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 RUNX1T1	6.10e-06	189	61	5	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 ADAMTS3 LRP1 RUNX1T1	6.10e-06	189	61	5	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 ADAMTS3 LRP1 RUNX1T1 ADGRE2	6.10e-06	189	61	5	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	FBN1 LRP1 LAMA2 RUNX1T1 PROS1	6.10e-06	189	61	5	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	KCNMB2 PCSK5 FBN2 TENM3 LAMA2	6.26e-06	190	61	5	3aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 RUNX1T1	6.26e-06	190	61	5	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 RUNX1T1	6.26e-06	190	61	5	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ADAMTS3 LRP1 LAMA2 RUNX1T1	6.26e-06	190	61	5	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	JAG2 PCSK5 FBN1 RUNX1T1 TEK	6.26e-06	190	61	5	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 RUNX1T1	6.26e-06	190	61	5	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	6.42e-06	191	61	5	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 ADAMTS3 LRP1 RUNX1T1	6.42e-06	191	61	5	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 PCSK5 FBN1 RUNX1T1 TEK	6.42e-06	191	61	5	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	6.42e-06	191	61	5	8f6d592edc32fdb901af30501d4360512334e8c2
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 ADAMTS3 LRP1 RUNX1T1	6.58e-06	192	61	5	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 LRP1 RUNX1T1 ADGRE2	6.58e-06	192	61	5	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 ADAMTS3 LRP1 RUNX1T1	6.58e-06	192	61	5	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 LRP1 RUNX1T1 ADGRE2	6.58e-06	192	61	5	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 ADAMTS3 LRP1 RUNX1T1	6.58e-06	192	61	5	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNMB2 FBN2 TENM3 CNTNAP2 RUNX1T1	6.75e-06	193	61	5	010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ADAMTS3 ATRNL1 LAMA2 RUNX1T1	6.75e-06	193	61	5	09a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell	facs-MAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 FBN1 LRP1 LAMA2 PROS1	6.75e-06	193	61	5	f95b95c58a6edb8a03dd15ae166f47f9f33d8bd6
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 ADAMTS3 LRP1 RUNX1T1	6.75e-06	193	61	5	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	facs-MAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 FBN1 LRP1 LAMA2 PROS1	6.75e-06	193	61	5	85faf6c5ce4769615a4eca036e2ba307e176bb52
ToppCell	facs-MAT-Fat-3m-Mesenchymal\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 FBN1 LRP1 LAMA2 PROS1	6.75e-06	193	61	5	110a7d2ba7d066c2be38be98b643b76c520dd980
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	6.92e-06	194	61	5	81713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCell	droplet-Pancreas-Exocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 FBN1 FBN2 LAMA2 TEK	6.92e-06	194	61	5	775600880bb77781de48085d8744c1030223de1f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ADAMTS3 LRP1 LAMA2 RUNX1T1	6.92e-06	194	61	5	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 ADAMTS3 LRP1 RUNX1T1	6.92e-06	194	61	5	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	droplet-Pancreas-Exocrine-21m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 FBN1 FBN2 LAMA2 TEK	6.92e-06	194	61	5	04ecb609d233a4b12e275c604810937830363e17
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TENM3 ADAMTS3 LRP1 RUNX1T1	6.92e-06	194	61	5	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 ATRNL1 LRP1 LAMA2 RUNX1T1	6.92e-06	194	61	5	627cffe2d448e74fc5df92e74e5b922a73304137
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2	7.10e-06	195	61	5	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2	7.10e-06	195	61	5	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2	7.28e-06	196	61	5	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	PCW_07-8.5-Mesenchymal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FBN1 TENM3 LRP1 LAMA2 RUNX1T1	7.28e-06	196	61	5	8e10802f52e5e1853ea4ad34bf9a32a34e6112b5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 RUNX1T1	7.28e-06	196	61	5	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 LRP1 LAMA2 RUNX1T1	7.28e-06	196	61	5	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 LRP1 LAMA2 RUNX1T1	7.28e-06	196	61	5	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 ADGRE2	7.28e-06	196	61	5	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LRP1 LAMA2	7.28e-06	196	61	5	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 TENM3 ATRNL1 LAMA2 ADGRE2	7.28e-06	196	61	5	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
Drug	Cinchonine [118-10-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A	KCNMB2 NELL2 EXD3 FBN1 ATRNL1 CBFA2T2	1.21e-05	194	60	6	2789_UP
Drug	Gemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A	SLCO1C1 CBFA2T2 DLK2 CUL9 ZNF224 VPS13B	1.28e-05	196	60	6	2277_UP
Drug	Sisomicin sulfate [53179-09-2]; Up 200; 2.8uM; PC3; HT_HG-U133A	EXD3 SLCO1C1 CBFA2T2 CNTNAP2 ZNF224 RUNX1T1	1.32e-05	197	60	6	4014_UP
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	1.18e-05	3	59	2	DOID:65 (implicated_via_orthology)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	2.35e-05	4	59	2	DOID:0060249 (is_implicated_in)
Disease	autosomal recessive limb-girdle muscular dystrophy (is_implicated_in)	JAG2 LAMA2	3.92e-05	5	59	2	DOID:0110274 (is_implicated_in)
Disease	cortical thickness	JAG2 NELL2 FBN1 FBN2 MALRD1 ADAMTS3 LRP1 LAMA2 CUL9 RUNX1T1	6.55e-05	1113	59	10	EFO_0004840
Disease	aortic aneurysm	FBN1 LRP1	1.75e-04	10	59	2	EFO_0001666
Disease	Antimigraine preparation use measurement	LRP1 RUNX1T1	8.05e-04	21	59	2	EFO_0009939
Disease	transforming growth factor beta measurement	CNTNAP2 CUL9	1.34e-03	27	59	2	EFO_0004818
Disease	spontaneous coronary artery dissection	FBN1 LRP1	1.76e-03	31	59	2	EFO_0010820

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVSCGKFSDCWNTEG	ADGRE2	76	Q9UHX3
KQGLLGDCWFLCACA	CAPN10	66	Q9HC96
GDCWFLCACAALQKS	CAPN10	71	Q9HC96
NSCVSGCCCGWLTKT	DCAF16	171	Q9NXF7
LAGLSSSCCKWGCSK	RLN3	121	Q8WXF3
ACKANETCKCNGWKN	KAT2A	111	Q92830
NCSFSCGPDCWKLSQ	KCNMB2	96	Q9Y691
SWIDGCKNCTCLNGT	NELL2	286	Q99435
CSAKEWSCQLPCGQK	NFXL1	301	Q6ZNB6
WNCGRKASETCSGCN	RUNX1T1	516	Q06455
CKTPDCKGWCFFEDD	RBCK1	371	Q9BYM8
GWKGSTCAVAKNSSC	JAG2	741	Q9Y219
CNNTLCKPLAWKCDG	LRP1	3661	Q07954
GWKFLCTSCCGWLIN	ATP9B	91	O43861
NCWNCGRKASETCSG	CBFA2T2	506	O43439
QCKGKGALNCLSCVW	PCSK5	1626	Q92824
LWGVNCSNTCTCKNG	PEAR1	571	Q5VY43
VSWCFVCSKGGSLLC	NSD2	831	O96028
NWKGCDECFCSGVSN	LAMA2	511	P24043
CWNCGRKASETCSGC	CBFA2T3	556	O75081
ECGSSCTFEKGWCGW	MALRD1	1516	Q5VYJ5
CAKMAAACWTCGFLC	OR6N2	141	Q8NGY6
LCTRCCWASKGAAVG	FZD8	616	Q9H461
SKWEIKRCQCCGSSG	G2E3	251	Q7L622
GTECAAGKWCYKGHC	ADAMTS3	526	O15072
GVSKASCCCSLGKAW	FBN1	1556	P35555
WKSCTAIGGRCKNQC	DEFB112	51	Q30KQ8
CTANTNGCQWCDDKK	ATRNL1	676	Q5VV63
NGCQWCDDKKCISAN	ATRNL1	681	Q5VV63
KNIQGCSCKGWCGNK	KIF4A	1081	O95239
SRKNIQGCSCKGWCG	KIF4B	1081	Q2VIQ3
QGCSCKGWCGNKQCG	KIF4B	1086	Q2VIQ3
GCGTTCSKCGWASCF	CUL9	2176	Q8IWT3
CSKCGWASCFNCSFP	CUL9	2181	Q8IWT3
GGKCSQTWDSFKCTC	CNTNAP2	566	Q9UHC6
QCICHSGWAGKFCDK	DLK2	76	Q6UY11
VSRSSCCCSLGKAWG	FBN2	1601	P35556
CGWKGCTCTFKDRSK	HINFP	171	Q9BQA5
RCKNGGTWDGLKCQC	MUC17	4146	Q685J3
LGDSCCFSAKALCVW	RXFP3	206	Q9NSD7
SCCGKFNEKSECTWT	TRIM45	551	Q9H8W5
FTCTCKPGWQGEKCE	PROS1	141	P07225
KGCSVCCKSSWNQLQ	SUV39H1	6	O43463
CCGGSWSCPSTFQKK	C11orf52	6	Q96A22
QSCCYLWCGKGCSGD	VIL1	551	P09327
DQVQCFCCGGKLKNW	XIAP	196	P98170
CLKWGFKRCGSRGSC	SLCO1C1	616	Q9NYB5
CGCICNEGWFGKNCS	TNR	186	Q92752
CEECGKAFNWCSSLT	ZNF682	231	O95780
KGRCLCFSGWKGTEC	TENM3	561	Q9P273
TCKDGKCECSQGWNG	TENM3	721	Q9P273
GCSCATGWKGLQCNE	TEK	286	Q02763
YNCKECGKSFGWASC	ZNF225	456	Q9UK10
DFHCWMCGKNCNSEK	ZC3H7A	856	Q8IWR0
GPCCATANLEAKWCK	VPS13B	2206	Q7Z7G8
ECKECGKAFSWLTCF	ZNF443	561	Q9Y2A4
KCSECGKSFCWNSGL	ZNF26	511	P17031
NCKECGKSFGWASCL	ZNF224	541	Q9NZL3
KACKCDCQGGPNALW	RS1	36	O15537
YKCPDCGKCFSWSSN	ZNF629	206	Q9UEG4
CKQCGKSFSWCHSFQ	ZNF763	286	Q0D2J5
ACSDCGLSFGWKKNL	ZNF467	356	Q7Z7K2
NGDKCNECKECWKAF	ZNF461	241	Q8TAF7
FQCKECGMNFSWSCS	ZKSCAN5	801	Q9Y2L8
CKECGKAFFWGSSLA	ZNF283	321	Q8N7M2
CCTGCGKVFWDGSHL	EXD3	831	Q8N9H8