Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAGI1 TNK1 ERBB2 HDAC4 INPP5E LARP1 CIC RUSC2 SH3PXD2B MAP7D1 FXR1 LATS1 FAM171A2 CASKIN2 STARD9 BRD4 FOXO4 IRS2 GNAS	2.45e-11	861	109	19	36931259
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ERBB2 RIN3 INPP5E BCL9 STK11IP ADGRA2 REXO1 CIC SH3PXD2B SLC38A10 KMT2D PWWP2B ZNF296 TMEM259 KCNH2 BRD4 FURIN ANKRD34A IRS2 MARVELD3 WNK2	3.11e-11	1105	109	21	35748872
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	RBM33 U2SURP CHD3 BCL9 CIC KMT2D EHMT2 BRD4 CDC73	1.82e-07	268	109	9	33640491
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	LARP1 CHD3 REST BCL9 REXO1 CIC KMT2D PWWP2B LATS1 BRD4 RBM6 IRS2 EIF3B	9.77e-07	774	109	13	15302935
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAGI1 HDAC4 GRIA3 BCL9 ATF6B SH3PXD2B MAP7D1 FXR1 FAM171A2 EHMT2 TMEM259 CDC73 DNM1 WNK2	1.98e-06	963	109	14	28671696
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	RTN4 LARP1 ECSIT STK11IP ZFPL1 MAP7D1 FXR1 LATS1 BRD4 IGHMBP2 EIF3B FOXC1	4.54e-06	754	109	12	33060197
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	CHD3 BCL9 CIC KMT2D FOXC1	6.59e-06	83	109	5	28794006
Pubmed	FoxO4 inhibits HBV core promoter activity through ERK-mediated downregulation of HNF4α.	HNF4A FOXO4	9.73e-06	2	109	2	31351930
Pubmed	Nectin-4 cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, enhancing their activation and DNA synthesis.	ERBB2 NECTIN4	9.73e-06	2	109	2	31831814
Pubmed	A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.	CIC FOXO4	9.73e-06	2	109	2	25007147
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	RIN3 RTN4 EHMT2 BRD4 MYO18B DNM1 WNK2 CNTFR	9.77e-06	329	109	8	17474147
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	ERBB2 HDAC4 RTN4 LARP1 EHMT2 ROBO1 IRS2 FOXC1	1.79e-05	358	109	8	32460013
Pubmed	Long non-coding RNA LINC00858 exerts a tumor-promoting role in colon cancer via HNF4α and WNK2 regulation.	HNF4A WNK2	2.91e-05	3	109	2	31884577
Pubmed	Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation.	ERBB2 NECTIN4	2.91e-05	3	109	2	33795719
Pubmed	Immunohistochemical Analysis of HER2, EGFR, and Nectin-4 Expression in Upper Urinary Tract Urothelial Carcinoma.	ERBB2 NECTIN4	2.91e-05	3	109	2	36585180
Pubmed	The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.	CHD3 KMT2D	2.91e-05	3	109	2	26551667
Pubmed	Regulation of USP37 Expression by REST-Associated G9a-Dependent Histone Methylation.	REST EHMT2	2.91e-05	3	109	2	28483947
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	HDAC4 RBM33 U2SURP LARP1 CHD3 BCL9 CIC MAP7D1 KMT2D TRIR PPP4R2 BRD4 CDC73	4.29e-05	1103	109	13	34189442
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	RBM33 U2SURP TACC2 BRD4 CDC73	5.78e-05	130	109	5	35545047
Pubmed	Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes.	HDAC4 HNF4A	5.82e-05	4	109	2	12205093
Pubmed	Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.	HDAC4 GNAS	5.82e-05	4	109	2	30030465
Pubmed	Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.	HDAC4 REST	5.82e-05	4	109	2	17011572
Pubmed	A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer.	ERBB2 GNAS	5.82e-05	4	109	2	34110646
Pubmed	Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.	U2SURP REXO1 CDC73	7.39e-05	26	109	3	33298525
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	RBM33 MCM10 REXO1 BRD4 RBM6 CDC73	7.41e-05	222	109	6	37071664
Pubmed	The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.	MAGI1 NLGN1 DNM1	9.27e-05	28	109	3	24448406
Pubmed	Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.	LATS1 GNAS	9.67e-05	5	109	2	31474569
Pubmed	SPOP mutation induces DNA methylation via stabilizing GLP/G9a.	EHMT2 BRD4	9.67e-05	5	109	2	34588438
Pubmed	Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.	BCL9 CDC73	9.67e-05	5	109	2	16630820
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	ERBB2 LATS1 EHMT2 KCNH2 BRD4 FURIN IRS2 KCTD2 DNM1 WNK2	1.03e-04	730	109	10	34857952
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CHD3 REST KMT2D FXR1 ZSCAN10 TRIR EHMT2 BRD4	1.19e-04	469	109	8	27634302
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	HDAC4 CHD3 REST KMT2D EHMT2	1.41e-04	157	109	5	30186101
Pubmed	BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling.	BCL9 CDC73	1.45e-04	6	109	2	17113272
Pubmed	Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival.	GRIA3 BRD4	1.45e-04	6	109	2	33015071
Pubmed	Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.	BCL9 HNF4A	1.45e-04	6	109	2	15574752
Pubmed	Repulsive axon guidance molecule Slit3 is a novel angiogenic factor.	IGHMBP2 ROBO1	1.45e-04	6	109	2	19741192
Pubmed	Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes.	REST EHMT2	1.45e-04	6	109	2	15200951
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	U2SURP LARP1 BCCIP EMILIN3 FXR1 KCTD2 CDC73	1.55e-04	364	109	7	24778252
Pubmed	RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.	BRD4 CDC73	2.02e-04	7	109	2	26659056
Pubmed	LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity.	KMT2D EHMT2	2.02e-04	7	109	2	37166352
Pubmed	PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.	EHMT2 CDC73	2.02e-04	7	109	2	29774127
Pubmed	Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity.	ERBB2 FOXO4	2.02e-04	7	109	2	15688030
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	RIN3 RTN4 LARP1 BCCIP CHD3 CIC BRD4 ZNF580 CDC73 DNM1 HSF4 CNTFR	2.15e-04	1124	109	12	21900206
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ERBB2 INPP5E RTN4 LARP1 ADGRA2 SHISAL1 CASKIN2 WNK2	2.69e-04	529	109	8	14621295
Pubmed	Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.	CACUL1 CHD3 BRD4	2.72e-04	40	109	3	28805822
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	MAGI1 TNK1 HDAC4 IRS2	3.06e-04	102	109	4	15778465
Pubmed	Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.	RNF185 TMEM259 RBM6	3.14e-04	42	109	3	32738194
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	BDP1 SLC38A10 KMT2D PPP4R2	3.55e-04	106	109	4	31024071
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CHD3 CIC MAP7D1 KMT2D EHMT2 BRD4 IRS2	3.59e-04	418	109	7	34709266
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	RTN4 TACC2 REST HNF4A CIC BRD4 IGHMBP2 FOXO4 ZNF580	4.03e-04	709	109	9	22988430
Pubmed	HiPLA: High-throughput imaging proximity ligation assay.	CHD3 EHMT2 BRD4	4.12e-04	46	109	3	30419336
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	MAGEL2 SPATA31E1 HDAC4 BCL9 CIC LATS1 WNK2	4.25e-04	430	109	7	35044719
Pubmed	CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.	REST EHMT2	4.31e-04	10	109	2	19061646
Pubmed	Esco2 is a novel corepressor that associates with various chromatin modifying enzymes.	HDAC4 EHMT2	4.31e-04	10	109	2	18501190
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	PRR4 ERBB2 RBM33 RTN4 PRSS56 DDI2 TACC2 BCL9 ZSCAN10 EHMT2 MARVELD3 GNAS	4.35e-04	1215	109	12	15146197
Pubmed	REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.	REST EHMT2	5.26e-04	11	109	2	15907476
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BDP1 RBM33 TACC2 CIC BABAM1 PPP4R2 RBM6 GNAS	5.43e-04	588	109	8	38580884
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	HDAC4 RBM33 BCCIP BCL9 CIC KMT2D RBM6	6.09e-04	457	109	7	32344865
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	LARP1 FXR1 CASKIN2 KCNH2 RBM6 IRS2	6.13e-04	329	109	6	34316702
Pubmed	Tagging genes with cassette-exchange sites.	HDAC4 LARP1 REST MCM10 REXO1 CDC73	6.73e-04	335	109	6	15741177
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BCCIP CHD3 MCM10 CIC TRIR EHMT2 BRD4 FOXC1	6.75e-04	608	109	8	36089195
Pubmed	Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).	CHD3 EHMT2 CDC73	6.98e-04	55	109	3	27114453
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	MAGI1 HDAC4 RTN4 LARP1 BCCIP HNF4A MAP7D1 BABAM1 PPP4R2 IRS2 ADI1 GNAS	7.07e-04	1284	109	12	17353931
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ERBB2 PRSS56 EMILIN3 CHD3 MAP7D1 FXR1 PWWP2B EHMT2 BRD4 IRS2 FOXC1	7.73e-04	1116	109	11	31753913
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RBM33 U2SURP LARP1 CHD3 CIC TRIR BRD4 RBM6 CDC73 FOXC1	8.49e-04	954	109	10	36373674
Pubmed	The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53.	U2SURP LARP1 FXR1	8.57e-04	59	109	3	32382008
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PERM1 MAP7D1 STARD9 ANKRD34A WNK2	8.58e-04	233	109	5	37704626
Pubmed	CCG repeats in cDNAs from human brain.	CHD3 MAP7D1	8.64e-04	14	109	2	9921901
Pubmed	A human MAP kinase interactome.	MAGI1 HDAC4 RBM33 CIC LATS1 ROBO1 WNK2	8.72e-04	486	109	7	20936779
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	KMT2D ETAA1 EIF3B GNAS	9.82e-04	139	109	4	25476789
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	LARP1 RUSC2 MAP7D1 BABAM1 STARD9 CDC73	9.91e-04	361	109	6	30344098
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BDP1 RBM33 RTN4 U2SURP MAP7D1 IGHMBP2 IRS2	9.93e-04	497	109	7	36774506
Pubmed	The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.	RTN4 TMEM259	9.95e-04	15	109	2	30704515
Pubmed	Genetic mutations associated with cigarette smoking in pancreatic cancer.	ERBB2 CDC73 GNAS	1.04e-03	63	109	3	19351817
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	RTN4 U2SURP LARP1 BCCIP CHD3 FXR1 EIF3B CDC73	1.07e-03	653	109	8	33742100
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	HNF4A IGHMBP2	1.13e-03	16	109	2	8861101
Pubmed	Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.	REST HNF4A	1.13e-03	16	109	2	22780989
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	RBM33 MCM10 BCL9 CIC	1.37e-03	152	109	4	38360978
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	INPP5E LARP1 CHD3 ATF6B FXR1 PLEKHG6 TMEM259 RBM6 IRS2 HSF4	1.41e-03	1021	109	10	26760575
Pubmed	Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes.	BRD4 FOXO4	1.44e-03	18	109	2	16897342
Pubmed	Wilms Tumor Predisposition	REST CDC73	1.44e-03	18	109	2	20301471
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	ERBB2 KMT2D BRD4	1.47e-03	71	109	3	28319113
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	RTN4 PRSS56 LARP1 STK11IP CLPTM1 GNAS	1.51e-03	392	109	6	33144569
Pubmed	Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges.	KCNH2 FOXC1	1.61e-03	19	109	2	27671872
Pubmed	Human transcription factor protein interaction networks.	RBM33 LARP1 CHD3 BCL9 HNF4A CIC MAP7D1 KMT2D EHMT2 RBM6 EIF3B FOXC1	1.76e-03	1429	109	12	35140242
Pubmed	Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.	REXO1 MAP7D1 CASKIN2	1.78e-03	76	109	3	10574461
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	MAGI1 HDAC4 INPP5E RTN4 U2SURP LARP1 FXR1 LATS1 IGHMBP2 EIF3B GNAS	1.87e-03	1247	109	11	27684187
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	LARP1 CHD3 EHMT2 CDC73 FOXC1	1.99e-03	282	109	5	23667531
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	RBM33 CHD3 TRIR BRD4 CDC73	2.02e-03	283	109	5	30585729
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	MAGI1 ERBB2 RTN4 LARP1 SH3PXD2B CASKIN2 NECTIN4	2.06e-03	565	109	7	25468996
Pubmed	Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.	ZNF296 EHMT2	2.16e-03	22	109	2	28963472
Pubmed	Defining human ERAD networks through an integrative mapping strategy.	RTN4 KMT2D TMEM259 CLPTM1	2.19e-03	173	109	4	22119785
Pubmed	Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.	DNAJC4 ERBB2 RUSC2	2.29e-03	83	109	3	20029029
Pubmed	Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.	SEPTIN4 GRIA3 ROBO1	2.29e-03	83	109	3	19799774
Pubmed	Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.	HNF4A LATS1	2.36e-03	23	109	2	27531557
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	MAGI1 KMT2D	2.36e-03	23	109	2	9225980
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJC4 RTN4 BCCIP ECSIT ATF6B FAM171A2 EHMT2 CASKIN2 CLPTM1 ROBO1 ADI1 GNAS	2.44e-03	1487	109	12	33957083
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	RNF185 MAP7D1 FXR1 TRIR TMEM259	2.45e-03	296	109	5	34186245
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	U2SURP LARP1 CIC MAP7D1 EHMT2 EIF3B FOXC1	2.45e-03	583	109	7	29844126
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	BDP1 MAGI1 ERBB2 HDAC4 MAN1C1 LARP1 CHD3 PWWP2B RBM6 ADI1 GNAS WNK2	2.47e-03	1489	109	12	28611215
Interaction	TOP3B interactions	ERBB2 RIN3 HDAC4 RBM33 INPP5E BCL9 STK11IP ADGRA2 REXO1 CIC SH3PXD2B SLC38A10 KMT2D FXR1 PWWP2B ZNF296 TMEM259 KCNH2 BRD4 FURIN ANKRD34A IRS2 MARVELD3 GNAS WNK2	1.81e-07	1470	108	25	int:TOP3B
Interaction	ZBTB21 interactions	MAGI1 HDAC4 INPP5E LARP1 HNF4A CIC FXR1 BRD4 ANKRD34A	2.11e-07	161	108	9	int:ZBTB21
Interaction	YWHAH interactions	MAGI1 TNK1 RIN3 EVC2 HDAC4 INPP5E LARP1 CIC RUSC2 SH3PXD2B MAP7D1 FXR1 LATS1 FAM171A2 CASKIN2 KCNH2 STARD9 BRD4 FOXO4 IRS2 WNK2	3.35e-07	1102	108	21	int:YWHAH
Interaction	SH3PXD2A interactions	MAGI1 RIN3 HDAC4 INPP5E RTN4 LARP1 SH3PXD2B ANKRD34A	4.39e-07	128	108	8	int:SH3PXD2A
Interaction	YWHAZ interactions	BDP1 TNK1 ERBB2 RIN3 HDAC4 INPP5E LARP1 TACC2 CIC RUSC2 MAP7D1 LATS1 FAM171A2 STARD9 BRD4 ANKRD34A FOXO4 IRS2 CDC73 WNK2	2.08e-05	1319	108	20	int:YWHAZ
Interaction	YWHAB interactions	MAGI1 TNK1 RIN3 HDAC4 INPP5E LARP1 BCCIP CIC RUSC2 MAP7D1 LATS1 FAM171A2 STARD9 ANKRD34A FOXO4 IRS2 CDC73	2.70e-05	1014	108	17	int:YWHAB
Interaction	LRRC47 interactions	RIN3 HDAC4 CIC BABAM1 PPP4R2 BRD4	3.61e-05	115	108	6	int:LRRC47
Interaction	PPM1H interactions	MAGI1 HDAC4 INPP5E LARP1 FXR1 ANKRD34A	5.27e-05	123	108	6	int:PPM1H
Interaction	APOC3 interactions	RNF185 LATS1 TMEM259 BRD4	6.14e-05	40	108	4	int:APOC3
Interaction	DCLK1 interactions	MAGI1 HDAC4 INPP5E LARP1 CIC ANKRD34A	6.30e-05	127	108	6	int:DCLK1
Interaction	UBP1 interactions	HDAC4 CIC FXR1 BRD4 FOXC1	6.62e-05	79	108	5	int:UBP1
Interaction	PAX9 interactions	BCL9 CIC KMT2D EHMT2 ZNF580 FOXC1	7.17e-05	130	108	6	int:PAX9
Interaction	KLF5 interactions	LARP1 BCL9 CIC KMT2D EHMT2 BRD4 RBM6	8.72e-05	195	108	7	int:KLF5
Interaction	SRGAP2 interactions	MAGI1 HDAC4 INPP5E LARP1 ANKRD34A ROBO1 GNAS	9.29e-05	197	108	7	int:SRGAP2
Interaction	NFIB interactions	BCL9 HNF4A CIC KMT2D BRD4 FOXC1	1.17e-04	142	108	6	int:NFIB
Interaction	YWHAE interactions	TNK1 HDAC4 INPP5E LARP1 BCCIP TACC2 MCM10 CIC RUSC2 MAP7D1 LATS1 KCNH2 BRD4 ANKRD34A IRS2 CDC73 WNK2 FOXC1	1.17e-04	1256	108	18	int:YWHAE
GeneFamily	Zinc fingers AN1-type\|UPF1 like RNA helicases	ZFAND2B IGHMBP2	3.20e-04	8	62	2	63
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	RBM33 LARP1 REXO1 CIC KMT2D EHMT2 TMEM259 FURIN FOXO4 ZNF580 EIF3B HSF4	1.78e-08	338	109	12	M17094
Disease	HELLP syndrome (is_marker_for)	ERBB2 ADAMTS13	7.49e-05	4	105	2	DOID:13133 (is_marker_for)
Disease	Brachydactyly	HDAC4 GNAS	7.49e-05	4	105	2	C0221357
Disease	Klippel-Feil syndrome	GDF6 MYO18B	7.49e-05	4	105	2	cv:C0022738
Disease	Intellectual Disability	HDAC4 INPP5E CHD3 ARMC9 PCDH12 CIC BRD4 GNAS	2.02e-04	447	105	8	C3714756
Disease	head and neck squamous cell carcinoma (is_marker_for)	ERBB2 CDC73	3.46e-04	8	105	2	DOID:5520 (is_marker_for)
Disease	idiopathic pulmonary fibrosis (is_implicated_in)	EHMT2 BRD4	4.44e-04	9	105	2	DOID:0050156 (is_implicated_in)
Disease	Childhood Medulloblastoma	ERBB2 BRD4 IRS2	4.87e-04	43	105	3	C0278510
Disease	Melanotic medulloblastoma	ERBB2 BRD4 IRS2	4.87e-04	43	105	3	C1275668
Disease	Medullomyoblastoma	ERBB2 BRD4 IRS2	4.87e-04	43	105	3	C0205833
Disease	Desmoplastic Medulloblastoma	ERBB2 BRD4 IRS2	4.87e-04	43	105	3	C0751291
Disease	Adult Medulloblastoma	ERBB2 BRD4 IRS2	4.87e-04	43	105	3	C0278876
Disease	Head and Neck Carcinoma	ERBB2 CDC73	5.54e-04	10	105	2	C3887461
Disease	Microphthalmos	PRSS56 KMT2D	6.76e-04	11	105	2	C0026010
Disease	Medulloblastoma	ERBB2 BRD4 IRS2	7.60e-04	50	105	3	C0025149
Disease	response to tenofovir	RIN3 SEPTIN4 WNK2	8.05e-04	51	105	3	EFO_0009279
Disease	obsolete_red blood cell distribution width	INPP5E RTN4 U2SURP LARP1 BCCIP REST REXO1 TMEM259 BRD4 CLPTM1 RBM6 IRS2 ATP2B3	9.95e-04	1347	105	13	EFO_0005192
Disease	Schizophrenia	MAGI1 HDAC4 RTN4 GRIA3 NLGN1 REST BCL9 KCNH2 GNAS DNM1	1.22e-03	883	105	10	C0036341
Disease	oral squamous cell carcinoma (is_marker_for)	ERBB2 KMT2D CDC73	1.49e-03	63	105	3	DOID:0050866 (is_marker_for)
Disease	Profound Mental Retardation	HDAC4 INPP5E CIC GNAS	1.56e-03	139	105	4	C0020796
Disease	Mental Retardation, Psychosocial	HDAC4 INPP5E CIC GNAS	1.56e-03	139	105	4	C0025363
Disease	Mental deficiency	HDAC4 INPP5E CIC GNAS	1.56e-03	139	105	4	C0917816
Disease	cortical thickness	MAGI1 RIN3 INPP5E GDF6 TACC2 ADGRA2 C17orf58 SH3PXD2B FURIN ROBO1 WNK2	2.05e-03	1113	105	11	EFO_0004840
Disease	laryngeal squamous cell carcinoma (is_marker_for)	ERBB2 CDC73	2.06e-03	19	105	2	DOID:2876 (is_marker_for)
Disease	left atrial function	GDF6 MYO18B	2.52e-03	21	105	2	EFO_0004294
Disease	Joubert syndrome 1	INPP5E ARMC9	2.52e-03	21	105	2	C4551568
Disease	Antihypertensive use measurement	NLGN1 FURIN RBM6 CNTFR FOXC1	2.62e-03	265	105	5	EFO_0009927
Disease	Intrahepatic Cholangiocarcinoma	ERBB2 GNAS	3.29e-03	24	105	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	ERBB2 GNAS	3.29e-03	24	105	2	C3805278
Disease	alkaline phosphatase measurement	RIN3 CACUL1 INPP5E U2SURP CHD3 ADAMTS13 HNF4A BRD4 CLPTM1 MARVELD3	3.36e-03	1015	105	10	EFO_0004533

Protein segments in the cluster

Peptide	Gene	Start	Entry
PAVTPQPPARPQDDE	BARGIN	11	Q6ZT62
NQPDVRPQPPSPREG	ERBB2	1141	P04626
NPQRGRESPRPPDPA	BDP1	26	A6H8Y1
LRERGPPQPLPAVQP	AKAP2	651	Q9Y2D5
RAEPGQQQPAAEPPP	EIF3B	16	P55884
EGRAPEQRPAPNAAP	CDC73	261	Q6P1J9
MEPGQPREPQEPREP	NT5C1A	1	Q9BXI3
PREPQEPREPGPGAE	NT5C1A	6	Q9BXI3
DVGRPVIRPPEQNAP	BRD4	1156	O60885
PPEPEPPADQQLRFR	ADGRA2	581	Q96PE1
GNGQPPVPEKRPPEI	EHMT2	191	Q96KQ7
ENEERLRAPPPPSPN	ATP2B3	1166	Q16720
PAPQPRRLLPGPQEN	ADAMTS13	1171	Q76LX8
PQPVPPTEGRPGIER	ANKRD34A	256	Q69YU3
EAAVDGFRQPLPPPP	CACUL1	26	Q86Y37
VPSQPRPAVGPQRFP	RBM33	406	Q96EV2
TPEPEAQPVGPPSRV	ITPKC	336	Q96DU7
PEPQPATGQPRSRPL	PCDH12	866	Q9NPG4
GAPRPGDIPENPPER	KASH5	466	Q8N6L0
GVVQKEPAQREPPPP	REST	786	Q13127
PPGPPRFQQVPTDAL	LARP1	736	Q6PKG0
EPPREVEPGQRQPSE	HDAC4	571	P56524
PPSNPEPAREVPLQG	MAGI1	441	Q96QZ7
GPPPVRQAPPLIRQA	MAGEL2	426	Q9UJ55
GFAPLQPQAAEPPPR	NCF2	216	P19878
ENLRPSEPAPQPPEG	INPP5E	6	Q9NRR6
GQRVNPPPPPQVRSV	LATS1	231	O95835
QVPSRPNRAPPGVPS	DNM1	831	Q05193
QVPFNEVRLPPPPDI	FXR1	41	P51114
QEEPRPAPTGTPRQP	ARMC9	726	Q7Z3E5
PAPTGTPRQPREAPQ	ARMC9	731	Q7Z3E5
PGPRAQPLLEAPQRP	C17orf58	46	Q2M2W7
PPGAPELPQEGPTRR	KCNH2	1121	Q12809
ESGVPQPPDPPVQRD	BCCIP	11	Q9P287
PRPRGQAATPETPQP	HNF4A	421	P41235
RDPQSPPDPPNEFGI	GRIA3	591	P42263
RPGEQVPPVPSPQDL	FLT3LG	216	P49771
ERAQPPPPQDPLGRR	FAM157A	241	C9JC47
PRPEIANQPSEPPEV	FOXO4	36	P98177
QERNPEAPGRAAVPP	ABCC11	46	Q96J66
PLGAQPPRDPQVAPR	EVC2	41	Q86UK5
GRRQDSPQPPATPLP	FAM161B	421	Q96MY7
RQPPAQPPRTGSEFP	MCM10	601	Q7L590
AAPPTGERRFQPPEP	NLGN1	86	Q8N2Q7
PPQERNLPEGTERPP	CASKIN2	726	Q8WXE0
GPPGPVRQREQPPTA	ETAA1	51	Q9NY74
GPARAFPQPDPQRPQ	FAM171A2	571	A8MVW0
PDPQAPQRRSAPELP	PLEKHG6	636	Q3KR16
IDVREEPGLPPQPQP	IRS2	1256	Q9Y4H2
PPPAPEVQIRTPRVN	BABAM1	76	Q9NWV8
GNAPGPQPPPVRIQD	FOXC1	211	Q12948
APQQADGNPDVPPPR	CHD3	526	Q12873
DGNPDVPPPRPLQGR	CHD3	531	Q12873
PPQQQPPRLPPEVEA	FURIN	686	P09958
PGNNPIFPRIPVEGP	BCL9	671	O00512
PPENVVARPVPSNPR	CNTFR	206	P26992
RQPPPSEPTQGPEIV	DNAJC4	221	Q9NNZ3
PEGPRNAQQPEPGDP	HSF4	341	Q9ULV5
EAPEPPQPQRKGDPG	MARVELD3	136	Q96A59
REQEPPPNPAPAAPA	MAN1C1	76	Q9NR34
PAPARGPRTPNLNPN	TMEM259	21	Q4ZIN3
PSGQVGPRPAPPQEE	MAP7D1	71	Q3KQU3
EPQIPSGQLDPGPRP	EMILIN3	146	Q9NT22
DPRPPVQFPNLPRID	DDI2	81	Q5TDH0
LPRVVQAQRGPQPPP	C1orf127	286	Q8N9H9
PDNPRETVAAPPGPQ	C4orf54	1536	D6RIA3
PPARGVQPPETTRPE	PWWP2B	86	Q6NUJ5
PGPGLPPEPREQRDV	SLC38A10	661	Q9HBR0
PEPGPRSPVQEDRPG	PERM1	236	Q5SV97
EQSLVPSPPEPRQRP	ECSIT	51	Q9BQ95
RTSAPEPRGPPNPNV	PPP4R2	61	Q9NY27
GRPRPQALLQDPPEP	PRSS56	71	P0CW18
DRQPGGRPQPPTLDP	PCARE	1196	A6NGG8
PPQERGKPAEPPRDR	RIN3	186	Q8TB24
VAQPLEPGPGPPERA	KCTD2	51	Q14681
VGRTPPARPPQDPAE	ODF3L2	186	Q3SX64
GREGQEPQPRPQDEP	GDF6	61	Q6KF10
EARARGPQQPPPPDL	GDF6	246	Q6KF10
PPQAPPPREGVVEGA	RUSC2	1311	Q8N2Y8
RGPLPAAPPVAPERQ	RTN4	91	Q9NQC3
QEVEPPRRGPAVPPA	REXO1	671	Q8N1G1
APRPSPPQEEARGPQ	STK11IP	466	Q8N1F8
PNQPLRPADKEPEPR	RBM6	591	P78332
QRLAQDEEPPPLPPR	SPATA2L	201	Q8IUW3
ASRPQVPEPRPQAPD	SEPTIN4	56	O43236
RDIPPEIGEQPEQPP	GNAS	16	Q5JWF2
NPARAPRPGQRAPQP	SHISAL1	151	Q3SXP7
AAPPPEQEGVQRPPR	SPATA31E1	921	Q6ZUB1
RPIPLPDQRPSANPG	STARD9	2896	Q9P2P6
PPPSGLPFNAQPRER	U2SURP	376	O15042
AVPIQPPGPPERDSV	ATF6B	551	Q99941
GPAPRQPLEPGPVRE	CIC	1201	Q96RK0
QPLEPGPVREPTAPE	CIC	1206	Q96RK0
IGRDPPAETQPQNPP	CLPTM1	31	O96005
REVPRPPVPQHPSGN	LINC01465	101	Q8N7H1
GRPTVPRQPLPGPED	C10orf105	106	Q8TEF2
PPSPTEQEGAVPRRP	ZNF513	251	Q8N8E2
GPSDEPPRPQPRAAQ	ZSCAN10	121	Q96SZ4
PPRPQPRAAQPAEPG	ZSCAN10	126	Q96SZ4
GPQRPAAPERSPQPR	TYMSOS	71	Q8TAI1
EQPPREQRGPDQPDL	IGHMBP2	816	P38935
PLQEAPQQRPVVPPR	SH3PXD2B	746	A1X283
RPQQAKEQPGPERPI	TACC2	1771	O95359
DRPPPVIRQGPVNQT	ROBO1	451	Q9Y6N7
GVPVQPPRPTDPNLI	ROBO1	546	Q9Y6N7
DPREKTPPRPQGQRP	RNF185	101	Q96GF1
TPPRPQGQRPEPENR	RNF185	106	Q96GF1
RSGQESPPPPQPGRD	MYO18B	1211	Q8IUG5
RPDQGPQRPPPEGLL	PRR4	41	Q16378
PEIRQARAVPQGPPG	TNK1	521	Q13470
PPRLPEEGVAPQDPA	TSPYL6	51	Q8N831
EAPGPQPPQPLQRRV	WNK2	61	Q9Y3S1
NVPVPVARGEPPDRA	ZFAND2B	61	Q8WV99
EEPRGPPQREAPPGE	ZNF580	71	Q9UK33
RQAPPGPPAQFQRPI	USP6	386	P35125
SQAPRPPASPGRPEQ	ZFPL1	181	O95159
EQRQRQEEPPPGPQR	TRIR	76	Q9BQ61
QEEPPPGPQRPDQSA	TRIR	81	Q9BQ61
PEPDAQPQQAPRLGP	ZNF296	36	Q8WUU4
ERSAGDPSQPRPNPP	KMT2D	3481	O14686
QPHRPDPGRPVGLEQ	ADI1	16	Q9BV57
GRVEQPPPPRNPLDG	NECTIN4	96	Q96NY8