Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR2 ITPR3

5.96e-083793GO:0005220
GeneOntologyMolecularFunctionligand-gated calcium channel activity

GRIN1 RYR1 ITPR1 ITPR2 ITPR3

1.34e-0731795GO:0099604
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 ITPR1 ITPR2 ITPR3

6.66e-0718794GO:0015278
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR1 ITPR1 ITPR2 ITPR3

8.51e-0633794GO:0005217
GeneOntologyMolecularFunctionchromatin-protein adaptor activity

TOPBP1 HTATSF1 PIH1D1 DNAJC2

2.06e-0541794GO:0140463
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR1 ITPR2 ITPR3

2.10e-0514793GO:0070679
GeneOntologyMolecularFunctiongated channel activity

KCNQ4 KCNS3 GRIN1 ANO3 RYR1 ITPR1 ITPR2 ITPR3

5.24e-05334798GO:0022836
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GRIN1 ANO3 RYR1 ITPR1 ITPR2 ITPR3

1.17e-04193796GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

GRIN1 ANO3 RYR1 ITPR1 ITPR2 ITPR3

1.31e-04197796GO:0022834
GeneOntologyMolecularFunctioncalcium channel activity

GRIN1 RYR1 ITPR1 ITPR2 ITPR3

1.60e-04129795GO:0005262
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

GRIN1 RYR1 ITPR1 ITPR2 ITPR3

2.34e-04140795GO:0099094
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

GRIN1 RYR1 ITPR1 ITPR2 ITPR3

3.33e-04151795GO:0015085
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNQ4 KCNS3 GRIN1 RYR1 ITPR1 ITPR2 ITPR3

4.17e-04343797GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNQ4 KCNS3 GRIN1 ANO3 RYR1 ITPR1 ITPR2 ITPR3

4.59e-04459798GO:0005216
GeneOntologyMolecularFunctionthiolester hydrolase activity

ACOT8 HIBCH PNKD

8.53e-0447793GO:0016790
GeneOntologyMolecularFunctionchannel activity

KCNQ4 KCNS3 GRIN1 ANO3 RYR1 ITPR1 ITPR2 ITPR3

1.10e-03525798GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNQ4 KCNS3 GRIN1 ANO3 RYR1 ITPR1 ITPR2 ITPR3

1.11e-03526798GO:0022803
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNQ4 KCNS3 GRIN1 RYR1 ITPR1 ITPR2 ITPR3

2.43e-03465797GO:0046873
GeneOntologyMolecularFunctioncalcium ion binding

LPCAT1 HMCN1 GRIN1 RET EFCAB7 RYR1 ITPR1 ITPR2 ITPR3

2.76e-03749799GO:0005509
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNQ4 KCNS3 GRIN1 RYR1

3.12e-03152794GO:0022843
GeneOntologyBiologicalProcessolfactory behavior

LMX1A LMX1B GRIN1

2.20e-0515773GO:0042048
GeneOntologyBiologicalProcessprotein localization to site of double-strand break

SLF2 TOPBP1 HTATSF1

2.71e-0516773GO:1990166
GeneOntologyBiologicalProcessaldehyde catabolic process

AKR1A1 ALDH3B1 PNKD

2.71e-0516773GO:0046185
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR1 ITPR2 ITPR3

4.46e-069803GO:0031095
GeneOntologyCellularComponentplatelet dense tubular network

ITPR1 ITPR2 ITPR3

8.71e-0611803GO:0031094
GeneOntologyCellularComponentsarcoplasmic reticulum

RYR1 ITPR1 ITPR2 ITPR3

3.63e-0488804GO:0016529
DomainRIH_assoc

RYR1 ITPR1 ITPR2 ITPR3

4.42e-096794PF08454
DomainRIH_assoc-dom

RYR1 ITPR1 ITPR2 ITPR3

4.42e-096794IPR013662
DomainRIH_dom

RYR1 ITPR1 ITPR2 ITPR3

4.42e-096794IPR000699
DomainIns145_P3_rcpt

RYR1 ITPR1 ITPR2 ITPR3

4.42e-096794IPR014821
DomainRyanodine_recept-rel

RYR1 ITPR1 ITPR2 ITPR3

4.42e-096794IPR015925
Domain-

RYR1 ITPR1 ITPR2 ITPR3

4.42e-0967941.25.10.30
DomainRYDR_ITPR

RYR1 ITPR1 ITPR2 ITPR3

4.42e-096794PF01365
DomainIns145_P3_rec

RYR1 ITPR1 ITPR2 ITPR3

4.42e-096794PF08709
DomainMIR

RYR1 ITPR1 ITPR2 ITPR3

6.11e-0810794PS50919
DomainMIR

RYR1 ITPR1 ITPR2 ITPR3

6.11e-0810794PF02815
DomainMIR

RYR1 ITPR1 ITPR2 ITPR3

6.11e-0810794SM00472
DomainMIR_motif

RYR1 ITPR1 ITPR2 ITPR3

6.11e-0810794IPR016093
DomainInsP3_rcpt-bd

ITPR1 ITPR2 ITPR3

7.28e-083793IPR000493
DomainIon_trans_dom

KCNQ4 KCNS3 RYR1 ITPR1 ITPR2 ITPR3

8.76e-06114796IPR005821
DomainIon_trans

KCNQ4 KCNS3 RYR1 ITPR1 ITPR2 ITPR3

8.76e-06114796PF00520
DomainSOXp

SOX1 SOX2

1.75e-045792PF12336
DomainSOX_fam

SOX1 SOX2

1.75e-045792IPR022097
DomainETS_DOMAIN_1

ETV4 SPDEF ELK4

2.21e-0428793PS00345
DomainETS_DOMAIN_2

ETV4 SPDEF ELK4

2.21e-0428793PS00346
DomainETS

ETV4 SPDEF ELK4

2.21e-0428793SM00413
DomainEts_dom

ETV4 SPDEF ELK4

2.21e-0428793IPR000418
DomainETS_DOMAIN_3

ETV4 SPDEF ELK4

2.21e-0428793PS50061
DomainEts

ETV4 SPDEF ELK4

2.21e-0428793PF00178
DomainTPR_2

P4HA1 TMTC2 TTC3

1.24e-0350793PF07719
DomainTPR_2

P4HA1 TMTC2 TTC3

1.24e-0350793IPR013105
Domain-

SOX1 SOX2 CCDC124

1.63e-03557931.10.30.10
DomainTPR_repeat

P4HA1 TTC21B TMTC2 TTC3

2.44e-03133794IPR019734
DomainHMG_box_dom

SOX1 SOX2 CCDC124

2.63e-0365793IPR009071
DomainTPR-contain_dom

P4HA1 TTC21B TMTC2 TTC3

3.77e-03150794IPR013026
DomainQuino_amine_DH_bsu

TEP1 TBL3

3.86e-0322792IPR011044
DomainTPR_REGION

P4HA1 TTC21B TMTC2 TTC3

5.28e-03165794PS50293
DomainTPR

P4HA1 TTC21B TMTC2 TTC3

5.28e-03165794PS50005
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

8.05e-075623M49000
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR1 ITPR1 ITPR2 ITPR3

1.25e-0619624M47760
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.61e-066623M47960
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

6.68e-069623M47852
PathwayWP_DOPAMINERGIC_NEUROGENESIS

SOX2 LMX1A LMX1B RET

8.53e-0630624M39580
PathwayWP_DOPAMINERGIC_NEUROGENESIS

SOX2 LMX1A LMX1B RET

8.53e-0630624MM15831
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

9.51e-0610623M47661
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

KCNS3 ITPR1 ITPR2 ITPR3

1.11e-0532624MM14983
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.30e-0511623M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR1 ITPR2 ITPR3

1.30e-0511623M27466
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

GRIN1 ITPR1 ITPR2 ITPR3

1.80e-0536624M39831
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

2.25e-0513623M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

2.25e-0513623M47751
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

2.25e-0513623M47656
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

2.25e-0513623MM14553
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

KCNS3 ITPR1 ITPR2 ITPR3

3.35e-0542624M791
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

4.36e-0516623M26945
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

ITPR1 ITPR2 ITPR3

7.47e-0519623M27423
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

7.47e-0519623M47733
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

8.76e-0520623M47688
PathwayREACTOME_ION_HOMEOSTASIS

RYR1 ITPR1 ITPR2 ITPR3

9.10e-0554624M27460
PathwayREACTOME_ION_HOMEOSTASIS

RYR1 ITPR1 ITPR2 ITPR3

9.10e-0554624MM15202
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

RET ITPR1 ITPR2 ITPR3

9.78e-0555624M47952
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.02e-0421623M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.18e-0422623M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.18e-0422623M47675
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

GRIN1 RYR1 PLCE1 ITPR1 ITPR2 ITPR3

1.27e-04178626M2890
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.35e-0423623M47676
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

KCNS3 ITPR1 ITPR2 ITPR3

1.47e-0461624MM15071
PathwayREACTOME_CA2_PATHWAY

PDE6B ITPR1 ITPR2 ITPR3

1.56e-0462624M27321
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2 ITPR3

1.74e-0425623MM14511
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2 ITPR3

2.20e-0427623M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

2.20e-0427623MM15053
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

2.45e-0428623M924
PathwayKEGG_LONG_TERM_POTENTIATION

GRIN1 ITPR1 ITPR2 ITPR3

2.50e-0470624M3115
PathwayKEGG_LONG_TERM_DEPRESSION

RYR1 ITPR1 ITPR2 ITPR3

2.50e-0470624M8232
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

KCNS3 ITPR1 ITPR2 ITPR3

2.79e-0472624MM14631
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

RYR1 ITPR1 ITPR2 ITPR3

3.10e-0474624M48080
PathwayWP_ALZHEIMERS_DISEASE

GRIN1 ITPR1 ITPR2 ITPR3

3.10e-0474624MM15962
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

PLCE1 ITPR1 ITPR2 ITPR3

3.43e-0476624M9052
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

KCNS3 ITPR1 ITPR2 ITPR3

3.79e-0478624M1921
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

ITPR1 ITPR2 ITPR3

5.22e-0436623M1315
PathwayREACTOME_DAG_AND_IP3_SIGNALING

ITPR1 ITPR2 ITPR3

7.67e-0441623M512
PathwayREACTOME_FORMATION_OF_THE_POSTERIOR_NEURAL_PLATE

SOX1 SOX2

8.37e-0410622M48036
PathwayWP_GENES_CONTROLLING_NEPHROGENESIS

LMX1B ETV4 RET

9.44e-0444623M39891
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

ITPR1 ITPR2 ITPR3

9.44e-0444623M39845
PathwayWP_NEPHROTIC_SYNDROME

LMX1B TTC21B PLCE1

1.01e-0345623M39864
PathwaySIG_CHEMOTAXIS

ITPR1 ITPR2 ITPR3

1.01e-0345623M5193
PathwayREACTOME_FORMATION_OF_THE_ANTERIOR_NEURAL_PLATE

SOX1 SOX2

1.02e-0311622M48031
PathwaySIG_BCR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.07e-0346623M8626
PathwayREACTOME_CARDIAC_CONDUCTION

RYR1 ITPR1 ITPR2 ITPR3

1.08e-03103624MM15196
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

KCNS3 ITPR1 ITPR2 ITPR3

1.29e-03108624M17034
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.37e-0350623M47951
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR1 ITPR1

1.44e-0313622M39589
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR1 ITPR2 ITPR3

1.62e-0353623MM15716
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

ITPR1 ITPR2 ITPR3

1.71e-0354623M26911
PathwayWP_GPR40_PATHWAY

PLCE1 ITPR3

1.93e-0315622M39526
PathwayWP_AIRWAY_SMOOTH_MUSCLE_CELL_CONTRACTION

RYR1 ITPR3

2.20e-0316622M40060
PathwayREACTOME_CARDIAC_CONDUCTION

RYR1 ITPR1 ITPR2 ITPR3

2.55e-03130624M27454
PathwayWP_SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4_SIGNALING

ELK4 ITPR1

3.44e-0320622M39485
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

PDE6B ITPR1 ITPR2 ITPR3

3.87e-03146624M27288
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

RYR1 ITPR1 ITPR2 ITPR3

3.96e-03147624MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

RYR1 ITPR1 ITPR2 ITPR3

4.36e-03151624M39329
PathwayREACTOME_PLATELET_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

4.53e-0376623MM15051
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR1 ITPR1 ITPR2 ITPR3

3.88e-10680423463619
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR1 ITPR1 ITPR2 ITPR3

3.88e-10680425966694
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR1 ITPR1 ITPR2 ITPR3

3.88e-10680420519450
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR1 ITPR1 ITPR2 ITPR3

3.88e-10680416844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR1 ITPR1 ITPR2 ITPR3

9.03e-10780411860456
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR1 ITPR2 ITPR3

1.17e-08380310874040
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR1 ITPR2 ITPR3

1.17e-08380320395455
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR1 ITPR2 ITPR3

1.17e-08380317437169
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR1 ITPR2 ITPR3

1.17e-08380318547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR1 ITPR2 ITPR3

1.17e-08380336350267
Pubmed

The versatility and universality of calcium signalling.

ITPR1 ITPR2 ITPR3

1.17e-08380311413485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

1.17e-08380326009177
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR1 ITPR2 ITPR3

1.17e-0838031693919
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR1 ITPR2 ITPR3

1.17e-08380323955339
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR1 ITPR2 ITPR3

1.17e-08380331979185
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR1 ITPR2 ITPR3

1.17e-08380324904548
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR1 ITPR2 ITPR3

1.17e-0838039858485
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR1 ITPR2 ITPR3

1.17e-0838039808793
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR1 ITPR2 ITPR3

1.17e-08380318194433
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR1 ITPR2 ITPR3

1.17e-08380327777977
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR1 ITPR2 ITPR3

1.17e-08380317581770
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR1 ITPR2 ITPR3

1.17e-08380318241669
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR1 ITPR2 ITPR3

1.17e-08380319068129
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

1.17e-08380317327232
Pubmed

Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.

RYR1 ITPR1 ITPR2

1.17e-08380323223241
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR1 ITPR2 ITPR3

1.17e-08380316014380
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR1 ITPR2 ITPR3

1.17e-08380317890015
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR1 ITPR2 ITPR3

1.17e-08380323983250
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

1.17e-08380320427533
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR1 ITPR2 ITPR3

4.68e-08480325215520
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

RYR1 ITPR1 ITPR2

4.68e-08480319120137
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

4.68e-08480311163362
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR1 ITPR2 ITPR3

4.68e-08480321424589
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR1 ITPR2 ITPR3

4.68e-08480328615414
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR1 ITPR2 ITPR3

4.68e-08480310828023
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR1 ITPR2 ITPR3

4.68e-08480328419336
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR1 ITPR2 ITPR3

4.68e-08480335494252
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR1 ITPR2 ITPR3

1.17e-07580321568942
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

2.33e-07680321762810
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

PLCE1 ITPR1 ITPR2 ITPR3

2.66e-072480410843712
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR1 ITPR2 ITPR3

4.07e-07780322495310
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR1 ITPR2 ITPR3

6.51e-07880319033399
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR1 ITPR2 ITPR3

9.75e-07980325737585
Pubmed

Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells.

SOX1 SOX2 LMX1B

9.75e-07980318522499
Pubmed

Cell-autonomous FGF signaling regulates anteroposterior patterning and neuronal differentiation in the mesodiencephalic dopaminergic progenitor domain.

SOX2 LMX1A LMX1B ETV4

1.45e-063680422278924
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

RYR1 ITPR1 ITPR2 ITPR3

1.80e-063880430786075
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR1 ITPR2 ITPR3

1.91e-061180327514653
Pubmed

Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.

SOX1 SOX2 LMX1A

2.54e-061280327246266
Pubmed

Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.

ITPR1 ITPR2 ITPR3

4.19e-061480334630045
Pubmed

GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function.

LMX1A LMX1B RET

4.19e-061480328076782
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

5.23e-0628029065779
Pubmed

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.

ITPR1 ITPR3

5.23e-06280215890645
Pubmed

Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.

ITPR1 ITPR2

5.23e-06280215201137
Pubmed

Long-term potentiation and long-term depression in hippocampal CA1 neurons of mice lacking the IP(3) type 1 receptor.

RYR1 ITPR1

5.23e-06280212654335
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

5.23e-0628028081734
Pubmed

Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.

ITPR1 ITPR2

5.23e-06280223582047
Pubmed

Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9.

LMX1A LMX1B

5.23e-0628029441763
Pubmed

SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway.

SOX1 SOX2

5.23e-06280226040764
Pubmed

Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease?

LMX1A LMX1B

5.23e-06280219189040
Pubmed

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

ITPR2 ITPR3

5.23e-06280215632133
Pubmed

Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.

ITPR1 ITPR3

5.23e-0628027559486
Pubmed

Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.

ITPR1 ITPR3

5.23e-06280220843799
Pubmed

Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.

ITPR1 ITPR2

5.23e-06280219120126
Pubmed

Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice.

NDOR1 ZDHHC17

5.23e-06280227927242
Pubmed

Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells.

SOX2 ST6GAL1

5.23e-06280231610800
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

5.23e-06280217496801
Pubmed

Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.

ITPR1 ITPR3

5.23e-0628028663526
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

5.23e-06280224901844
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

5.23e-06280233854148
Pubmed

RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial-mesenchymal transition via MAPK/SOX2 pathway in bladder cancer.

SOX2 RASAL2

5.23e-06280228182001
Pubmed

An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.

ITPR1 ITPR2

5.23e-06280218708078
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

5.23e-06280219528657
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

5.23e-0628028063813
Pubmed

Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy.

NDOR1 USP39

5.23e-06280237923718
Pubmed

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

ITPR1 ITPR3

5.23e-0628021374893
Pubmed

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

ITPR2 ITPR3

5.23e-06280216195467
Pubmed

Case report of adrenocortical carcinoma associated with double germline mutations in MSH2 and RET.

MSH2 RET

5.23e-06280233615670
Pubmed

Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors.

RYR1 ITPR3

5.23e-06280221150295
Pubmed

Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.

LMX1A LMX1B

5.23e-06280228094018
Pubmed

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.

ITPR1 ITPR3

5.23e-06280220813840
Pubmed

Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.

ITPR2 ITPR3

5.23e-06280215713744
Pubmed

Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.

LMX1A LMX1B

5.23e-06280226526610
Pubmed

Expression and reconstitution of the bioluminescent Ca(2+) reporter aequorin in human embryonic stem cells, and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes.

RYR1 ITPR1

5.23e-06280227430888
Pubmed

Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.

ITPR1 ITPR3

5.23e-06280214707143
Pubmed

A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel.

CHGB ITPR1

5.23e-06280214506248
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

ITPR1 ITPR2 ITPR3

5.23e-061580328578927
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

SOX1 SOX2 P4HA1 BCAS2 AKR1A1 TTC3 EFCAB7 TBL3 RYR1 ITPR2

7.01e-06732801034732716
Pubmed

Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons.

SOX2 LMX1A LMX1B

7.79e-061780320610763
Pubmed

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon.

SOX2 LMX1A LMX1B

9.33e-061880318820178
Pubmed

Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect.

SOX2 LMX1A LMX1B

1.51e-052180319842188
Pubmed

Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction.

SOX1 SOX2

1.57e-0538029609835
Pubmed

Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons.

NDOR1 RET

1.57e-05380230018091
Pubmed

Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.

ITPR1 ITPR2

1.57e-05380232320395
Pubmed

Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity.

NDOR1 GRIN1

1.57e-05380216140270
Pubmed

Expression of Sox1, Sox2 and Sox9 is maintained in adult human cerebellar cortex.

SOX1 SOX2

1.57e-05380219061938
Pubmed

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.

ITPR1 ITPR3

1.57e-05380218250332
Pubmed

Sox2-Deficient Müller Glia Disrupt the Structural and Functional Maturation of the Mammalian Retina.

SOX1 SOX2

1.57e-05380227031842
Pubmed

Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity.

LMX1A LMX1B

1.57e-0538029199284
Pubmed

Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.

ITPR2 ITPR3

1.57e-05380221435446
Pubmed

Distinct SoxB1 networks are required for naïve and primed pluripotency.

SOX1 SOX2

1.57e-05380229256862
InteractionCAMK2G interactions

KIF23 ARHGAP25 GRIN1 TRIM37 RYR1 ITPR1 ITPR2 ITPR3

4.53e-06240798int:CAMK2G
InteractionTRPC1 interactions

KIF23 ITPR1 ITPR2 ITPR3

4.82e-0629794int:TRPC1
InteractionIRAG1 interactions

ITPR1 ITPR2 ITPR3

2.05e-0514793int:IRAG1
InteractionTESPA1 interactions

ITPR1 ITPR2 ITPR3

3.13e-0516793int:TESPA1
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR2 ITPR3

4.23e-083643297
GeneFamilyETS transcription factor family

ETV4 SPDEF ELK4

1.30e-0428643534
GeneFamilyLIM class homeoboxes

LMX1A LMX1B

7.96e-0412642522
GeneFamilySRY-boxes

SOX1 SOX2

2.03e-0319642757
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ART3 TMTC2 ALDH3B1 EFCAB7 LDB2 PLCE1

8.58e-07179806c7c74e26bbf86c5326ee38bac7de111d5414f46b
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

HMCN1 HIBCH ST6GAL1 LDB2 ITPR1 ITPR2

1.18e-06189806c81787a8c662db5d7814c583dd64562857629e81
ToppCellfacs-Lung-Endomucin_-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TMTC2 TRIM37 RGS12 HYAL2 LDB2

1.37e-06194806df56e23f1dcf1902d29392fcc947e0e268e1648b
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

VILL LMX1A LMX1B KCNS3 RET

1.24e-051668056a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCelldroplet-Liver-LIVER-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 MR1 KCNS3 ELK4 LDB2

1.64e-051768054d2fb51e71bed0d72f3d7f89d395744860885a5f
ToppCelldroplet-Liver-LIVER-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 MR1 KCNS3 ELK4 LDB2

1.64e-051768054880fa20b50eb10358e08567e08559ef2954f237
ToppCelldroplet-Liver-LIVER-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 MR1 KCNS3 ELK4 LDB2

1.64e-05176805fcdddd949ca05b3ecde240db9e38296a6eab2d6a
ToppCellControl|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN4 DTL TMTC2 RASAL2 LDB2

1.69e-05177805b8ff6940e31b749776e81ae4f5bbd577dba9749c
ToppCell3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL3RA HYAL2 LDB2 ITPR1 NXPE3

1.93e-05182805d996ceb77c83591df4cef144ca72862f31d9777f
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SOX1 SOX2 LMX1B GRIN1 CHGB

2.14e-05186805c7983281a290201567b398e9ea6baddb96c692bb
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TMTC2 ELK4 TRIM37 ITPR2

2.14e-051868050ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

HMCN1 HIBCH ST6GAL1 LDB2 ITPR2

2.31e-0518980575c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HMCN1 RGS12 HYAL2 RASAL2 LDB2

2.43e-0519180538fe60a8570f3c6eb8e8f8646f90d505dfd7d647
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HMCN1 RGS12 HYAL2 RASAL2 LDB2

2.43e-051918050e6cd2628a5cebd35e960e4eb3b52ddc9358031c
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

HMCN1 HIBCH ST6GAL1 LDB2 ITPR2

2.49e-05192805c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMTC2 ST6GAL1 HYAL2 RASAL2 LDB2

2.49e-051928051ee4783051ec94ea94600f040edcb385fc4289f1
ToppCellfacs-Lung-Endomucin_-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMTC2 TRIM37 RGS12 HYAL2 LDB2

2.49e-05192805ba3fe97786564dba1c8185f2802ce1b57f4f3cc9
ToppCellfacs-Lung-Endomucin_|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMTC2 TRIM37 RGS12 HYAL2 LDB2

2.49e-0519280585d4d0df701451daf95e94a87a0096da1e86533b
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HMCN1 TRIM37 RGS12 HYAL2 LDB2

2.55e-051938050f19b6384659a5bcc11b45dc2df8454b96ddf4cd
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMTC2 TRIM37 RGS12 HYAL2 LDB2

2.55e-051938052218833749576ba1a0fc95bd155c781e7e1163c6
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMTC2 TRIM37 RGS12 HYAL2 LDB2

2.55e-051938051b6317b740cad2439f08b9e9895426d861e7a161
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HMCN1 TRIM37 RGS12 HYAL2 LDB2

2.55e-05193805a586727dc23b0777770f54fc8d4fe5f30b68439f
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMTC2 TRIM37 RGS12 HYAL2 LDB2

2.55e-05193805f5861cfa4401b476229a7c61cd64abad79a4bbfc
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HMCN1 TRIM37 RGS12 HYAL2 LDB2

2.55e-05193805ee4b31d9c92f8fd0d3ddb5e723b82300fcb459d1
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HMCN1 TMTC2 ST6GAL1 HYAL2 LDB2

2.55e-051938057261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HMCN1 TRIM37 RGS12 HYAL2 LDB2

2.55e-051938057401e276b644b254c692160d0e7417ec28d50aa4
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TRIM37 RGS12 HYAL2 LDB2

2.62e-05194805e30a3765feae5cd10ddba16a166c31eb5717edd3
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SOX1 SOX2 LMX1B CHGB RET

2.62e-05194805ccff0b5814f5de2d42720018e7f5dc5dcdafb568
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMTC2 ST6GAL1 HYAL2 RASAL2 LDB2

2.62e-05194805fa6d51f36a3dae8763a595c20892987ed454c0f0
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 ART3 HYAL2 RASAL2 LDB2

2.68e-0519580512ba6d95e42d06b1991b011043c0e3370a7b4131
ToppCellLV-09._Endothelium_I|World / Chamber and Cluster_Paper

HMCN1 TMTC2 HYAL2 RASAL2 LDB2

2.68e-0519580519e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCellLA-09._Endothelium_I|LA / Chamber and Cluster_Paper

HMCN1 TMTC2 HYAL2 RASAL2 LDB2

2.82e-05197805ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

HMCN1 TMTC2 HYAL2 RASAL2 LDB2

2.82e-05197805f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellCaecum-(1)_T_cell-(18)_cycling_gd_T|Caecum / shred on region, Cell_type, and subtype

MORC1 KIF23 DTL RYR1 RASAL2

2.89e-0519880564278d8831c81874937e76b561c53928dfc437c5
ToppCellCaecum-T_cell-cycling_gd_T|Caecum / Region, Cell class and subclass

MORC1 KIF23 DTL RYR1 RASAL2

2.89e-051988055b719b67f8384863077070e1eb7e04a320e6dab4
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

HMCN1 TMTC2 HYAL2 LDB2 ITPR2

3.03e-052008057eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Glia_progenitor_cell|GW12 / Sample Type, Dataset, Time_group, and Cell type.

MR1 ALDH3B1 TEP1 RYR1 ITPR2

3.03e-052008054b937b1d0179d1d0e51931f35720e205d460a07e
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MORC1 HMCN1 RET RGS12

7.39e-0512480436dfc702a570e1a1a6dde09f38badf9023ea7287
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Nxph2_Wls|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DTL CHGB ANO3 LDB2

8.88e-0513080405d5a73acf1d7f75a79876b1a06d27c74a89b8a4
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ART3 DTL ARHGAP25 LDB2

9.98e-051348046d97fa07f55ae20c17b9d5262e893957cccc6dba
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NDOR1 GRIN1 TEP1 IL3RA

9.98e-051348040e3f37ef041b751ed45060b5ce39385a2731370b
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KIF23 DTL RET TCEAL9

1.25e-04142804e160f35b3c18e77c4107fe96db5f56227c91785e
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX1 KCNQ4 RET EPHA3

1.35e-04145804590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCelldroplet-Lung-3m-Hematologic-myeloid-intermediate_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VILL ALDH3B1 CCIN RYR1

1.54e-04150804b37f538ca5f976b509efe35dc81115b72b227084
ToppCelldroplet-Lung-3m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VILL ALDH3B1 CCIN RYR1

1.54e-041508042c7518918c40e1bf679a2d4e83b472ee6f2f9df8
ToppCell356C-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PDE6B RET CCDC191 ANO3

1.58e-041518042dc132895609e4efe17954e31f53d9c1ccf256ef
ToppCell356C-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PDE6B RET CCDC191 ANO3

1.58e-0415180422afd8201eff8471da3456be065f2790de5e4bfe
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell-Peri-Peri_Kcnj8|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ART3 CCDC141 PLCE1 ITPR2

1.75e-04155804ced64e26962c5c6e6d539f361fe57ab0b399e999
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ART3 CCDC141 PLCE1 ITPR2

1.75e-041558040f24ef6486aef354f0911c06932cb01d1a0525ac
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SOX1 SOX2 KCNQ4 RGS12

1.75e-04155804105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell-Peri|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ART3 CCDC141 PLCE1 ITPR2

1.75e-04155804d8b5145258f075b15080f8739f537f48dd22225e
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NUDT6 KCNQ4 TTC21B ITPR1

1.84e-04157804f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX1 SOX2 KCNQ4 KCNS3

1.93e-041598040dccc4275b9b4f8554dd556da7218e130bff8fd1
ToppCellfacs-Marrow-T-cells-24m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF605 HIBCH TTC3 CCDC191

1.97e-04160804b3f7ef7e682b48a83ca425f5c439336e96168300
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CCDC124 VILL ARHGAP25 ANO3

2.02e-0416180466554f59eaea4ba55a6c6724f9368e24e99c91e9
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX2 VILL SPDEF ST6GAL1

2.12e-0416380422fa5d017ff796394394d952ec151e2d1beb8248
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

LPCAT1 PDE6B KCNS3 CCDC141

2.17e-0416480485f53d184fa70e3eb1af655807f32b17ddbfb304
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

LPCAT1 PDE6B KCNS3 CCDC141

2.17e-04164804144ba070a1ede71684224cc6d4ead3b7e6a7b4c6
ToppCellNS-control-d_0-4-Myeloid-pDC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAN2B1 CCDC141 IL3RA ITPR1

2.22e-041658048b2d43d7c4ee07bd999bd51bc15117ce1fbb2d86
ToppCellcontrol-Myeloid-pDC|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAN2B1 CCDC141 IL3RA ITPR1

2.22e-04165804243c74adf8d993ff92acbff2768bdc5a1693eca3
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

PTPN4 ZNF605 KCNQ4 CCDC191

2.27e-0416680432d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC124 BCAS2 MSH2 IL3RA

2.43e-041698043e40ae0b23a962e0f15908872dec63f51c5b8b83
ToppCelldroplet-Marrow-BM-1m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN2B1 AKR1A1 TEP1 CTSA

2.43e-041698048066b4c02c97d00034802cff2b39799ef44cc904
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|metastatic_Brain / Location, Cell class and cell subclass

LMX1B TOPBP1 ZDHHC17 IL3RA

2.43e-0416980471f6761b9927f352e0ccc221ca373319915f4184
ToppCellMild-Treg|World / Disease group and Cell class

HMCN1 GRIN1 CHGB CCDC141

2.49e-04170804f3f177534badca34e1ae8671b7f583ee6688e14b
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNQ4 KCNS3 ANO3 ITPR2

2.49e-0417080417bd7fd25a2657cb536ad47e294332920f759e95
ToppCellfacs|World / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LPCAT1 SLF2 ELK4 CTSA

2.60e-04172804a2d0a64ebf09d219a07d6bbad1056bad6d46b9be
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL3RA HYAL2 LDB2 NXPE3

2.66e-04173804b57d14e2c2368304cb903562d06ce8228f53857c
ToppCellfacs-Lung-Endomucin-24m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TRIM37 HYAL2 LDB2

2.72e-04174804ea27868d0373843a5137569ac3f9e3f8c92c7dcc
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

P4HA1 IL3RA HYAL2 EPHA3

2.72e-04174804d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VILL ETV4 TMTC2 EFCAB7

2.72e-04174804c58328c2f262506a4518f49f148e29874faf9171
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL3RA HYAL2 RASAL2 ITPR3

2.72e-0417480442735f6a8e5ec36dd3d35aceea6d37cf3eaa1871
ToppCellfacs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TRIM37 HYAL2 LDB2

2.78e-04175804eedb33e3e350169d1d37f2ac9939dcf704e7b696
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TRIM37 HYAL2 LDB2

2.78e-041758041c7725f917f3d6b9e0a31ede9524690f408a5ea1
ToppCelldroplet-Marrow-nan-24m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN2B1 AKR1A1 TEP1 CTSA

2.84e-04176804eddac2ba68d234e3f56f4ca0e11c19bc0e95b6e1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 ANO3 RASAL2 EPHA3

2.84e-041768049bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 ANO3 RASAL2 EPHA3

2.84e-041768043f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NDOR1 CCDC124 KCNQ4 DNAJC2

2.84e-041768043c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

LMX1B TOPBP1 ZDHHC17 IL3RA

2.90e-0417780443e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCelldroplet-Marrow-nan-21m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN2B1 AKR1A1 TEP1 CTSA

2.90e-04177804b860013f1fd397400a62d66ab521cfc81349ffe2
ToppCellfacs-Lung-Endomucin|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TRIM37 HYAL2 LDB2

2.96e-04178804363e523233b1800a4c8e14c7b1a7814b8da29ccd
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPDEF GRIN1 RYR1 ITPR1

2.96e-04178804a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPDEF GRIN1 RYR1 ITPR1

2.96e-041788041bddbc083c36657bd6910f7466126ab325e88176
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LMX1A ETV4 CHGB ZDHHC17

3.03e-041798048ce5000088b727783a0619baa16a2cd036d21f54
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POM121L2 TMTC2 ST6GAL1 ITPR1

3.03e-04179804d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCellfacs-Heart-RA-24m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TRIM37 HYAL2 LDB2

3.09e-04180804174c643e046646e3b305dd7e5b120d2c9a46690f
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high|PND07-28-samps / Age Group, Lineage, Cell class and subclass

RGS12 HYAL2 RASAL2 LDB2

3.16e-041818049cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KIF23 HMCN1 ETV4 ITPR3

3.22e-04182804a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMCN1 IL3RA HYAL2 LDB2

3.22e-04182804d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TRIM37 HYAL2 LDB2

3.29e-041838041e51aeaa8fc9383b424cce128a890e07cb6025f3
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

TMTC2 HYAL2 RASAL2 LDB2

3.29e-04183804ff95382cfed592190d0636d2b750328471f82e0d
ToppCelldroplet-Large_Intestine-COLON:P+D-30m-Epithelial-large_intestine_goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPDEF ST6GAL1 TCEAL9 ITPR1

3.29e-04183804ee9c88be88221b7ad4ea9f890b17d6156fb3432e
ToppCelldroplet-Large_Intestine-COLON:P+D-30m-Epithelial-Goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPDEF ST6GAL1 TCEAL9 ITPR1

3.29e-04183804c52b84034503d931f7b87312d2ff86daff14152d
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX2 ETV4 RET ITPR3

3.36e-041848047aa245b73e10fd73d292e822de6b72920aa12355
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ART3 ANO3 LDB2 EPHA3

3.36e-04184804ca35a3d2b536c8b2bf5c4d635605e5a3ae94a428
ToppCelldroplet-Heart-4Chambers-21m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 TMTC2 TRIM37 HYAL2

3.36e-04184804f17d713af4a97dff4eeeab24c405677ef2ffcf84
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KCNQ4 KCNS3 EPHA3 PLCE1

3.36e-04184804102b6f621a5b551e622f97b12d787c080b052a72
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL3RA HYAL2 RASAL2 LDB2

3.43e-04185804a987dbf6adf533c5f8a0a8a465a6c8e67e0ffcc8
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

AKR1A1 CTSA TCEAL9 HYAL2

3.43e-041858040e8064bb317f26959d3c59b4f73d0c455161ccd7
ToppCell(5)_Pericytes|World / Cell class and subclass of bone marrow stroma cells in homeostatis

ART3 KCNQ4 CCDC141 PLCE1

3.50e-04186804acbca8cc048d87faf859b3e77bdb38d0a3dad71c
DrugAC1Q7BER

RYR1 ITPR1 ITPR3

7.98e-076793CID000005702
DrugBr2BAPTA

RYR1 ITPR1 ITPR3

1.39e-067793CID003081001
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR1 ITPR1 ITPR3

1.39e-067793CID009547999
DrugClorocruoro Hem

ART3 RET RYR1 PLCE1 ITPR1 ITPR3

4.43e-06123796CID003518809
Drug(+,-)-Synephrine [94-07-5]; Down 200; 24uM; HL60; HT_HG-U133A

HTATSF1 POM121L2 ELK4 RET TEP1 HYAL2 RASAL2

5.05e-061947976156_DN
DrugEtofenamate [30544-47-9]; Up 200; 10.8uM; MCF7; HT_HG-U133A

PDE6B KCNS3 TEP1 RGS12 RASAL2 ITPR2 ITPR3

5.78e-061987977327_UP
DrugR 478

RYR1 ITPR1 ITPR3

6.50e-0611793CID000084223
Drug8-amino-cADPR

RYR1 ITPR1 ITPR3

6.50e-0611793CID003081323
DrugFura-2AM

ACOT8 ART3 RYR1 ITPR1 ITPR3

8.16e-0679795CID000105091
Drugadenophostin A

ITPR2 ITPR3

1.19e-052792ctd:C085029
DrugIsocaffeine

ITPR1 ITPR3

1.19e-052792CID000001326
Drugadenophostin B

ITPR1 ITPR3

1.19e-052792CID000656722
Drugbenzene 1,2,4-trisphosphate

ITPR1 ITPR3

1.19e-052792CID000192376
DrugGvapspat amide

RYR1 ITPR1 ITPR3

1.78e-0515793CID000125015
DrugAC1L1BDQ

LPCAT1 ART3 LMX1A EPHA3 ITPR1 ITPR3

3.10e-05173796CID000001394
Drug5-deoxy-5-fluoro-myo-inositol

ITPR1 ITPR3

3.56e-053792CID000195110
DrugAC1L92T5

PTPN4 MR1 SPDEF MSH2

4.30e-0556794CID000412123
DrugAC1L1CR9

RYR1 ITPR1 ITPR3

5.11e-0521793CID000002023
DrugMetrizamide [31112-62-6]; Up 200; 5uM; HL60; HT_HG-U133A

POM121L2 ELK4 ZDHHC17 TEP1 HYAL2 ITPR2

6.04e-051957961318_UP
DrugBicuculline (+) [485-49-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A

NDOR1 PDE6B TICAM1 ST6GAL1 RYR1 ITPR1

6.04e-051957962796_UP
Drugpioglitazone HCl; Up 200; 10uM; MCF7; HT_HG-U133A

HTATSF1 POM121L2 RGS12 RASAL2 ITPR1 NXPE3

6.40e-051977965972_UP
DrugArticaine hydrochloride [23964-57-0]; Up 200; 12.4uM; HL60; HT_HG-U133A

PDE6B TICAM1 SPDEF ST6GAL1 ELK4 RGS12

6.40e-051977963138_UP
DrugNSC717817

ART3 MR1 PNKD

6.77e-0523793CID005287845
DrugCHEBI:697555

ITPR1 ITPR3

7.10e-054792CID009578246
DrugT0702

RYR1 ITPR1 ITPR3

8.75e-0525793CID000005908
DrugAC1L9ZFX

NDOR1 ART3 PLCE1 ITPR1 ITPR3

1.04e-04134795CID000504578
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR2 ITPR3

3.15e-0612733DOID:1441 (implicated_via_orthology)
DiseaseAnoxic Encephalopathy

ITPR1 ITPR2

6.04e-062732C0003132
DiseaseBrain Hypoxia

ITPR1 ITPR2

6.04e-062732C1527348
DiseaseAnoxia of brain

ITPR1 ITPR2

6.04e-062732C0995195
DiseaseHypoxic Brain Damage

ITPR1 ITPR2

6.04e-062732C1140716
DiseaseSchizophrenia

LMX1A LMX1B KCNS3 AKR1A1 CHGB ALDH3B1 CCDC86 IL3RA RGS12

3.23e-04883739C0036341
Diseasecumulative dose response to bevacizumab

PTPN4 KCNS3

1.00e-0319732EFO_0005944
DiseaseRenal glomerular disease

LMX1B PLCE1

1.48e-0323732C0268731
DiseaseGlomerulopathy Assessment

LMX1B PLCE1

1.48e-0323732C4521256
DiseaseKallmann Syndrome

SOX2 CCDC141

1.89e-0326732C0162809
Diseaseresponse to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema

LMX1A POM121L2

1.89e-0326732EFO_0005325, EFO_0005532, EFO_0010735
Diseaseobesity (implicated_via_orthology)

ETV4 ITPR1 ITPR2 ITPR3

2.01e-03215734DOID:9970 (implicated_via_orthology)
Diseasefunctional brain measurement, language measurement

EPHA3 PLCE1

2.19e-0328732EFO_0007797, EFO_0007849
DiseaseAutosomal dominant nonsyndromic hearing loss

LMX1A KCNQ4

2.35e-0329732cv:C5779548

Protein segments in the cluster

PeptideGeneStartEntry
ARNQLKRIAKMNWNA

TTC21B

1176

Q7Z4L5
SQLQRMEPKQMFWVR

ACOT8

196

O14734
QMLQDKPLRTSWQRK

CCDC86

256

Q9H6F5
QNLNRQRKRKEYWDM

CCIN

16

Q13939
RNLRAWMKDERVPKN

ALDH3B1

76

P43353
SPENKNWLLAMAAKR

DTL

656

Q9NZJ0
NWLLAMAAKRKAENP

DTL

661

Q9NZJ0
RWSNKKNVPKLGDMN

DNAJC2

191

Q99543
FRRIKNWMAQNPMVL

ANO3

251

Q9BYT9
WGIQKNRPAMNYDKL

ETV4

381

P43268
NRVRMNTFPWLKIVK

PTPN4

246

P29074
EMKWQKKIRNNPALF

ITPR2

2206

Q14571
AQMIKNKNLDWFPRM

ITPR3

2591

Q14573
TLNMIRQIYPQLKKW

HIBCH

61

Q6NVY1
FNPWMRIFIQAKRVK

MORC1

246

Q86VD1
NAIRKKNEGVNWLRM

CHMP1A

51

Q9HD42
KRRAQSNGKWPQIMI

LPCAT1

191

Q8NF37
PQNVSLWAHRKMLQK

HYAL2

101

Q12891
EMNWQKKLRAQPVLY

ITPR1

2261

Q14643
WEPKLMKAFQRNRSR

KIAA2026

821

Q5HYC2
EKRRMPAANLIQAAW

KCNQ4

336

P56696
LKTCLFQKWQRMVAP

LDB2

231

O43679
VWFQNQRAKMKKLAR

LMX1A

241

Q8TE12
VQDRNKLKNMWKFPG

NUDT6

161

P53370
MFDRLQNNRKEWKAL

PDE6B

796

P35913
RDKWMENLRRTVQPN

RASAL2

146

Q9UJF2
QLRKKIWIRMENPAY

KCNS3

166

Q9BQ31
MRVNKRAPQMDWNRK

SLC9A3R2

316

Q15599
PPDNMKNFWRFIFRK

NDOR1

66

Q9UHB4
ERRWIKNSAMLLQNP

HMCN1

921

Q96RW7
SMQQKQLDWRPERRA

HTATSF1

241

O43719
PVNAFKLMKRLNTEW

P4HA1

81

P13674
NQKMEVQRRPWLVKY

CTSA

416

P10619
RMKAKAQQLTWDLNR

IL3RA

31

P26951
LDLRQKWNDMKPQFQ

CCDC141

721

Q6ZP82
VARLWGIRKNKPNMN

ELK4

41

P28324
NRNSKLMEPNLIKDW

EFCAB7

256

A8K855
PWKRLRMQSKQNIQV

CCDC191

756

Q8NCU4
LMLDCWQKDRNNRPK

EPHA3

856

P29320
NMWFKNLDKLIRLVN

MAN2B1

326

O00754
NQMDKARRHPQGAWK

CHGB

451

P05060
RAQWEMPQVKESKRQ

RYR1

4201

P21817
LVNQWIKQPLMDKNR

MSH2

341

P43246
KKEWLRSPDNPMNQR

CCDC124

201

Q96CT7
SNERKMIPIWKQQAR

NTAQ1

56

Q96HA8
QLLRGWQQMFKVELK

MR1

86

Q95460
RRVAAKQLEMQNKLW

KIF23

631

Q02241
WSRGQRRKMAQENPK

SOX2

51

P48431
DKDQRKQQAMWRVPS

TRIM37

656

O94972
PENLARERKMQWVQR

PNKD

306

Q8N490
LQLNPEWRMMKNRPF

PIH1D1

156

Q9NWS0
MRKLWNPRNFKAHVS

USP39

281

Q53GS9
WRPRKFKMRQFNDPD

NXPE3

331

Q969Y0
KMRKFPDQRQQWLRK

PLCE1

1011

Q9P212
IPRLQKIWKNYLSMN

ST6GAL1

106

P15907
INLMKNIRDWNTKVP

SLF2

966

Q8IX21
WSRGQRRKMAQENPK

SOX1

61

O00570
LRKHIQDLNWQRKNM

BCAS2

156

O75934
LANEAWRRFPMKKSQ

POM121L2

71

Q96KW2
MKQLNALNKNWRYIV

AKR1A1

286

P14550
NAPKREWSRKAFGMQ

RGS12

596

O14924
QHTLRWLNKPRTMKN

TEP1

1651

Q99973
KINFLMRKNRADPWQ

MRPS21

71

P82921
WGIRKNRPAMNYDKL

SPDEF

291

O95238
NTFKPHRLQARKAMW

TICAM1

526

Q8IUC6
KDQSVRIWRMNKAGQ

TBL3

396

Q12788
MSLKLPRNWDFNLKV

ARHGAP25

1

P42331
QSNLRKLWNIMEKQG

TMTC2

816

Q8N394
MPWKENMIFRNVNLK

TEX43

51

Q6ZNM6
YVVRNKKLWDMNPKQ

TTC3

1091

P53804
WLAMRFRNQKDPRAN

TSPAN31

191

Q12999
KLIVMRWKVNRNHPY

TCEAL9

86

Q9UHQ7
MATWRQRQEKKQLGF

VILL

841

O15195
YRLMLQCWKQEPDKR

RET

981

P07949
ALDLAKQRKNVWMIN

ZDHHC17

261

Q8IUH5
KRMGSKKRNWNLYPA

THUMPD3

411

Q9BV44
KKRNWNLYPACLREM

THUMPD3

416

Q9BV44
IMGPRKKFQWNDEIR

UBN1

506

Q9NPG3
ALAAMRWRKKIQQRQ

TOPBP1

1371

Q92547
NPKMWLRDNQDNLKS

ZNF605

51

Q86T29
INPRNSRWAEMKVKA

VN1R2

191

Q8NFZ6
AKWKRQQRQQMQTRP

LEUTX

61

A8MZ59
WFQNQRAKMKKLARR

LMX1B

266

O60663
KWAARKTQIFLPMNF

ART3

76

Q13508
KQMQLAFAAVNVWRK

GRIN1

846

Q05586