Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	5'-3' DNA helicase activity	BRIP1 IGHMBP2 DNA2	5.84e-06	11	67	3	GO:0043139
GeneOntologyMolecularFunction	helicase activity	BRIP1 IGHMBP2 HELZ2 CHD8 SMARCAD1 DNA2	1.50e-05	158	67	6	GO:0004386
GeneOntologyMolecularFunction	DNA helicase activity	BRIP1 IGHMBP2 CHD8 DNA2	5.58e-05	62	67	4	GO:0003678
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	BRIP1 IGHMBP2 CHD8 SMARCAD1 DNA2	6.77e-05	127	67	5	GO:0008094
GeneOntologyMolecularFunction	ATP-dependent activity	BRIP1 VWA8 IGHMBP2 HELZ2 TCIRG1 CHD8 SMARCAD1 DNA2 ATP6V0A2	2.02e-04	614	67	9	GO:0140657
GeneOntologyMolecularFunction	unmethylated CpG binding	KMT2A KDM2A	4.91e-04	10	67	2	GO:0045322
GeneOntologyMolecularFunction	ATP hydrolysis activity	BRIP1 VWA8 IGHMBP2 HELZ2 CHD8 SMARCAD1 DNA2	6.78e-04	441	67	7	GO:0016887
Domain	Leu-rich_rpt	LRRC3 NLRP12 LINGO1 SLITRK4 KDM2A NLRP2 RABGGTA PHLPP2 NLRP8 NLRP13	2.66e-08	271	64	10	IPR001611
Domain	-	LRRC3 NLRP12 LINGO1 SLITRK4 KDM2A NLRP2 RABGGTA PHLPP2 NLRP8 NLRP13	1.30e-07	321	64	10	3.80.10.10
Domain	L_dom-like	LRRC3 NLRP12 LINGO1 SLITRK4 KDM2A NLRP2 RABGGTA PHLPP2 NLRP8 NLRP13	1.59e-07	328	64	10	IPR032675
Domain	DAPIN	NLRP12 NLRP2 NLRP8 NLRP13	8.76e-07	22	64	4	PS50824
Domain	PYRIN	NLRP12 NLRP2 NLRP8 NLRP13	8.76e-07	22	64	4	PF02758
Domain	DAPIN	NLRP12 NLRP2 NLRP8 NLRP13	8.76e-07	22	64	4	IPR004020
Domain	PYRIN	NLRP12 NLRP2 NLRP8 NLRP13	8.76e-07	22	64	4	SM01289
Domain	NACHT	NLRP12 NLRP2 NLRP8 NLRP13	1.06e-06	23	64	4	PS50837
Domain	NACHT_NTPase	NLRP12 NLRP2 NLRP8 NLRP13	1.06e-06	23	64	4	IPR007111
Domain	-	NLRP12 BRIP1 VWA8 IGHMBP2 HELZ2 CHD8 SMARCAD1 DSEL DNA2 NLRP2 NLRP8 NLRP13	7.34e-06	746	64	12	3.40.50.300
Domain	P-loop_NTPase	NLRP12 BRIP1 VWA8 IGHMBP2 HELZ2 CHD8 SMARCAD1 DSEL DNA2 NLRP2 NLRP8 NLRP13	2.64e-05	848	64	12	IPR027417
Domain	LRR_6	NLRP12 NLRP2 NLRP8 NLRP13	3.75e-05	55	64	4	PF13516
Domain	SCAN	ZNF165 SCAND2P ZKSCAN8 ZNF232	4.03e-05	56	64	4	SM00431
Domain	SCAN_BOX	ZNF165 SCAND2P ZKSCAN8 ZNF232	4.63e-05	58	64	4	PS50804
Domain	SCAN	ZNF165 SCAND2P ZKSCAN8 ZNF232	4.63e-05	58	64	4	PF02023
Domain	SCAN_dom	ZNF165 SCAND2P ZKSCAN8 ZNF232	4.63e-05	58	64	4	IPR003309
Domain	LRR	LRRC3 NLRP12 LINGO1 SLITRK4 RABGGTA PHLPP2	6.43e-05	201	64	6	PS51450
Domain	V-type_ATPase_116kDa_su_euka	TCIRG1 ATP6V0A2	6.90e-05	4	64	2	IPR026028
Domain	V_ATPase_I	TCIRG1 ATP6V0A2	6.90e-05	4	64	2	PF01496
Domain	V-ATPase_116kDa_su	TCIRG1 ATP6V0A2	6.90e-05	4	64	2	IPR002490
Domain	LRR_1	LRRC3 LINGO1 SLITRK4 KDM2A RABGGTA PHLPP2	1.03e-04	219	64	6	PF00560
Domain	-	RNF220 RPH3AL RNFT2 RNF146 KMT2A KDM2A LNX1 TRIM74	1.43e-04	449	64	8	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF220 RPH3AL RNFT2 RNF146 KMT2A KDM2A LNX1 TRIM74	1.66e-04	459	64	8	IPR013083
Domain	-	NLRP12 NLRP2 NLRP8 NLRP13	2.91e-04	93	64	4	1.10.533.10
Domain	DEATH-like_dom	NLRP12 NLRP2 NLRP8 NLRP13	3.70e-04	99	64	4	IPR011029
Domain	DEXDc	BRIP1 IGHMBP2 CHD8 SMARCAD1	5.33e-04	109	64	4	SM00487
Domain	Helicase_ATP-bd	BRIP1 IGHMBP2 CHD8 SMARCAD1	5.51e-04	110	64	4	IPR014001
Domain	Znf_CXXC	KMT2A KDM2A	6.23e-04	11	64	2	IPR002857
Domain	ZF_CXXC	KMT2A KDM2A	6.23e-04	11	64	2	PS51058
Domain	zf-CXXC	KMT2A KDM2A	6.23e-04	11	64	2	PF02008
Domain	Retrov_capsid_C	ZNF165 ZKSCAN8 ZNF232	1.09e-03	59	64	3	IPR008916
Domain	Znf_RING_CS	RNFT2 RNF146 LNX1 TRIM74	2.36e-03	163	64	4	IPR017907
Domain	LRR_8	LRRC3 LINGO1 SLITRK4 PHLPP2	2.81e-03	171	64	4	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRRC3 LINGO1 SLITRK4 PHLPP2	3.18e-03	177	64	4	IPR003591
Domain	LRR_TYP	LRRC3 LINGO1 SLITRK4 PHLPP2	3.18e-03	177	64	4	SM00369
Domain	ZF_RING_1	RNF220 RNFT2 RNF146 LNX1 TRIM74	3.20e-03	291	64	5	PS00518
Domain	ZF_RING_2	RNF220 RNFT2 RNF146 LNX1 TRIM74	3.54e-03	298	64	5	PS50089
Domain	RING	RNF220 RNFT2 RNF146 LNX1 TRIM74	3.90e-03	305	64	5	SM00184
Domain	LRRNT	LRRC3 LINGO1 SLITRK4	4.63e-03	98	64	3	IPR000372
Domain	LRRNT	LRRC3 LINGO1 SLITRK4	4.63e-03	98	64	3	SM00013
Domain	Znf_RING	RNF220 RNFT2 RNF146 LNX1 TRIM74	5.17e-03	326	64	5	IPR001841
Domain	SNF2_N	CHD8 SMARCAD1	5.37e-03	32	64	2	IPR000330
Domain	SNF2_N	CHD8 SMARCAD1	5.37e-03	32	64	2	PF00176
Domain	DNA/RNA_helicase_DEAH_CS	BRIP1 CHD8	6.39e-03	35	64	2	IPR002464
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP12 NLRP2 NLRP8 NLRP13	1.24e-08	14	67	4	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP12 NLRP2 NLRP8 NLRP13	1.24e-08	14	67	4	12563287
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	VPS39 HELZ2 ADGRB3 KDM2A CHD8 MED13L GCN1	2.70e-07	225	67	7	12168954
Pubmed	The zinc finger-associated SCAN box is a conserved oligomerization domain.	ZNF165 SCAND2P ZKSCAN8	5.69e-07	9	67	3	10567577
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	MICALL1 MED16 MIOS KMT2A TSC2 EIF3I PEX11B	1.20e-06	281	67	7	24163370
Pubmed	Microglial ASD-related genes are involved in oligodendrocyte differentiation.	CHD8 TSC2	3.66e-06	2	67	2	34497307
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	RBM10 NCAPD2 KMT2A KDM2A CHD8 TSC2 SMARCAD1	4.30e-06	341	67	7	32971831
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MICALL1 VWA8 VPS39 HPS6 NCAPD2 MYOM3 HELZ2 CHD8 TSC2 MED13L GCN1	7.99e-06	1105	67	11	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MICALL1 VWA8 VPS39 NAT10 NCAPD2 ADGRB3 CHD8 DNA2	8.07e-06	529	67	8	14621295
Pubmed	Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation.	TCIRG1 ATP6V0A2	1.10e-05	3	67	2	10722719
Pubmed	From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiation.	TCIRG1 ATP6V0A2	1.10e-05	3	67	2	12672822
Pubmed	Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase.	TCIRG1 ATP6V0A2	1.10e-05	3	67	2	10702241
Pubmed	The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.	TCIRG1 ATP6V0A2	1.10e-05	3	67	2	23288846
Pubmed	A strategy for cloning the hereditary hemochromatosis gene.	ZNF165 ZKSCAN8	1.10e-05	3	67	2	8673473
Pubmed	Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain.	ZNF165 ZKSCAN8	2.19e-05	4	67	2	9244436
Pubmed	The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants.	IGHMBP2 TCIRG1	2.19e-05	4	67	2	10709991
Pubmed	Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron.	TCIRG1 ATP6V0A2	2.19e-05	4	67	2	17595521
Pubmed	Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues.	TCIRG1 ATP6V0A2	2.19e-05	4	67	2	17497178
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RNF220 BRIP1 NAT10 ZKSCAN8 KMT2A KDM2A CHD8 SMARCAD1	2.19e-05	608	67	8	36089195
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MED16 VPS39 RBM10 NAT10 TBC1D12 MIOS CHD8	2.24e-05	440	67	7	34244565
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ANKRD13A VPS39 MIOS TSC2 GCN1 ATP6V0A2	3.19e-05	313	67	6	38270169
Pubmed	The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.	VPS39 MIOS TSC2	3.58e-05	33	67	3	33452816
Pubmed	Osteosclerosis, a recessive skeletal mutation on chromosome 19 in the mouse.	HPS6 TCIRG1	3.64e-05	5	67	2	3998439
Pubmed	Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.	NLRP12 NLRP2	3.64e-05	5	67	2	17046979
Pubmed	The a subunit isoforms of vacuolar-type proton ATPase exhibit differential distribution in mouse perigastrulation embryos.	TCIRG1 ATP6V0A2	3.64e-05	5	67	2	35948619
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	NAT10 NCAPD2 KMT2A CHD8 GCN1	3.83e-05	195	67	5	19454010
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	HPS6 NAT10 NCAPD2 CHD8 SMARCAD1 GCN1	4.42e-05	332	67	6	32786267
Pubmed	Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.	TCIRG1 ATP6V0A2	5.46e-05	6	67	2	21307348
Pubmed	Optic nerve compression and retinal degeneration in Tcirg1 mutant mice lacking the vacuolar-type H-ATPase a3 subunit.	TCIRG1 ATP6V0A2	7.63e-05	7	67	2	20711468
Pubmed	The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.	MED16 MED13L	7.63e-05	7	67	2	12093747
Pubmed	Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification.	TCIRG1 ATP6V0A2	7.63e-05	7	67	2	19549681
Pubmed	Defining the membrane proteome of NK cells.	MED16 ANO6 IGHMBP2 HPS6 NAT10 NCAPD2 HELZ2 CD320 PEX11B GCN1	7.65e-05	1168	67	10	19946888
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RBM10 NAT10 NCAPD2 KMT2A KDM2A CHD8 GCN1	9.02e-05	549	67	7	38280479
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	TMEM130 VPS39 RBM10 RNF146 NAT10 CD320 PMFBP1 PHLPP2	9.57e-05	750	67	8	11230166
Pubmed	PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.	NLRP12 NLRP2	1.02e-04	8	67	2	12019269
Pubmed	Integral and associated lysosomal membrane proteins.	VPS39 MIOS TCIRG1 ATP6V0A2	1.05e-04	126	67	4	17897319
Pubmed	Survival and lung pathology of mouse models of Hermansky-Pudlak syndrome and Chediak-Higashi syndrome.	HPS6 RABGGTA	1.30e-04	9	67	2	10193444
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	RBM10 NAT10 KMT2A CHD8	1.34e-04	134	67	4	25452129
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	MED16 NAT10 NCAPD2 KMT2A KDM2A CHD8 SMARCAD1 EIF3I MED13L	1.38e-04	1014	67	9	32416067
Pubmed	DNA cloning using in vitro site-specific recombination.	TMEM130 VPS39 RBM10 RNF146 NAT10 ADCY8 PMFBP1 PHLPP2	1.42e-04	794	67	8	11076863
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KMT2A KDM2A	1.63e-04	10	67	2	29276034
Pubmed	Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development.	HPS6 RABGGTA	1.63e-04	10	67	2	12445206
Pubmed	Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.	VPS39 HPS6	1.63e-04	10	67	2	19010779
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	MED16 RBM10 KMT2A CHD8 MED13L	1.71e-04	268	67	5	33640491
Pubmed	The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.	MIOS TSC2	2.38e-04	12	67	2	25263562
Pubmed	NODs: intracellular proteins involved in inflammation and apoptosis.	NLRP8 NLRP13	2.38e-04	12	67	2	12766759
Pubmed	AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.	TSC2 GABBR2	2.38e-04	12	67	2	21436046
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NAT10 NCAPD2 HELZ2 KMT2A CHD8 EIF3I GCN1	2.61e-04	653	67	7	22586326
Pubmed	mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.	VPS39 TSC2	2.81e-04	13	67	2	25533187
Pubmed	Structure and Roles of V-type ATPases.	TCIRG1 ATP6V0A2	2.81e-04	13	67	2	32001091
Pubmed	SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.	FBXO9 KDM2A	3.28e-04	14	67	2	17463251
Pubmed	MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.	BRIP1 DNA2	3.78e-04	15	67	2	22678361
Pubmed	The LIFEdb database in 2006.	TMEM130 VPS39 RBM10 RNF146 NAT10 PMFBP1 PHLPP2	4.69e-04	720	67	7	16381901
Pubmed	From ORFeome to biology: a functional genomics pipeline.	TMEM130 VPS39 RBM10 RNF146 NAT10 PMFBP1 PHLPP2	4.77e-04	722	67	7	15489336
Pubmed	Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.	TCIRG1 ATP6V0A2	4.88e-04	17	67	2	33065002
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	VWA8 VPS39 ANO6 IGHMBP2 EIF3I DNA2 GCN1	6.16e-04	754	67	7	33060197
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	MED16 IGHMBP2 NAT10 ZKSCAN8 MIOS EIF3I GCN1	6.41e-04	759	67	7	35915203
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	KMT2A KDM2A PMFBP1	7.12e-04	90	67	3	15033168
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2A KDM2A	7.50e-04	21	67	2	27626377
Pubmed	Proton translocation driven by ATP hydrolysis in V-ATPases.	TCIRG1 ATP6V0A2	8.24e-04	22	67	2	12788495
Pubmed	Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes.	TCIRG1 ATP6V0A2	8.24e-04	22	67	2	14580332
Pubmed	Neurotransmitter release: the dark side of the vacuolar-H+ATPase.	TCIRG1 ATP6V0A2	8.24e-04	22	67	2	14597263
Pubmed	The vacuolar (H+)-ATPases--nature's most versatile proton pumps.	TCIRG1 ATP6V0A2	8.24e-04	22	67	2	11836511
Pubmed	Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.	TCIRG1 ATP6V0A2	8.24e-04	22	67	2	17662945
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	RBM10 NAT10 NCAPD2 CHD8 SMARCAD1 GCN1	9.00e-04	582	67	6	20467437
Pubmed	Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor.	TCIRG1 ATP6V0A2	1.07e-03	25	67	2	2874839
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	VWA8 MED16 RBM10 NAT10 HELZ2 ZKSCAN8 MIOS GCN1	1.10e-03	1082	67	8	38697112
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	VWA8 TBC1D12 ADGRB3	1.11e-03	105	67	3	9628581
Pubmed	The AP-3 complex: a coat of many colours.	HPS6 RABGGTA	1.34e-03	28	67	2	9714600
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	NLRP12 NLRP2	1.34e-03	28	67	2	25089626
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	RBM10 HELZ2 KDM2A DNA2	1.40e-03	250	67	4	33536335
Pubmed	Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.	KMT2A CHD8	1.64e-03	31	67	2	15960975
Pubmed	The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.	MED16 MED13L	1.64e-03	31	67	2	23322298
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	ANKRD13A MMS22L NCAPD2 EIF3I GCN1 ATP6V0A2	1.67e-03	657	67	6	36180527
Pubmed	A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.	BRIP1 RBM10 CHD8	1.67e-03	121	67	3	22412018
Pubmed	Characterization of long cDNA clones from human adult spleen.	KDM2A ZSWIM4	1.86e-03	33	67	2	11214971
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	RBM10 NAT10 CHD8 GCN1	1.88e-03	271	67	4	32433965
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	RBM10 NAT10 MED13L GCN1	1.91e-03	272	67	4	31010829
Cytoband	Ensembl 112 genes in cytogenetic band chr12q24	ANKRD13A RNFT2 MED13L GCN1 ATP6V0A2	3.85e-04	415	68	5	chr12q24
Cytoband	16q22.2	PMFBP1 PHLPP2	4.90e-04	22	68	2	16q22.2
Cytoband	11q13.2	TCIRG1 KDM2A	2.24e-03	47	68	2	11q13.2
Cytoband	1p34.1	RNF220 EIF3I	3.27e-03	57	68	2	1p34.1
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP12 NLRP2 NLRP8 NLRP13	4.87e-07	25	47	4	994
GeneFamily	NLR family	NLRP12 NLRP2 NLRP8 NLRP13	4.87e-07	25	47	4	666
GeneFamily	UPF1 like RNA helicases	IGHMBP2 HELZ2 DNA2	2.68e-06	11	47	3	1169
GeneFamily	Zinc fingers CXXC-type	KMT2A KDM2A	4.29e-04	12	47	2	136
GeneFamily	Ring finger proteins	RNF220 RNFT2 RNF146 LNX1 TRIM74	7.14e-04	275	47	5	58
GeneFamily	V-type ATPases	TCIRG1 ATP6V0A2	1.62e-03	23	47	2	415
GeneFamily	Cyclins\|Mediator complex	MED16 MED13L	3.32e-03	33	47	2	1061
Coexpression	GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN	ANKRD13A RNF220 KMT2A KDM2A CHD8 PEX11B	1.14e-05	197	67	6	M5877
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5	LRRC3 FBXO9 LINGO1 VWA8 ANO6 SLITRK4 ADGRB3 CHD8 MON1B GPR108 PHLPP2	1.23e-05	743	64	11	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#4	LRRC3 BRIP1 FBXO9 LINGO1 VWA8 ANO6 SLITRK4 ADGRB3 CHD8 PHLPP2	5.53e-05	721	64	10	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K4
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#2	LRRC3 BRIP1 FBXO9 LINGO1 VWA8 ANO6 SLITRK4 ADGRB3 CHD8 PHLPP2	7.43e-05	747	64	10	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K2
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A LRRC3 TMEM130 LINGO1 GABBR2	2.02e-06	137	67	5	4dcb15de821439011df1bb0bbd7682d674bd725d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A LRRC3 TMEM130 LINGO1 GABBR2	2.02e-06	137	67	5	c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	MMS22L BRIP1 RNFT2 NCAPD2 DNA2	9.95e-06	190	67	5	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	MMS22L BRIP1 RNFT2 NCAPD2 DNA2	1.07e-05	193	67	5	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
Disease	Wrinkly skin syndrome	KMT2A ATP6V0A2	5.23e-06	2	68	2	C0406587
Disease	sperm-associated antigen 11A measurement	NLRP12 MED16	1.57e-05	3	68	2	EFO_0802082
Disease	autosomal recessive osteopetrosis 1 (implicated_via_orthology)	TCIRG1 ATP6V0A2	5.21e-05	5	68	2	DOID:0110942 (implicated_via_orthology)
Disease	heparin cofactor 2 measurement	PMFBP1 PHLPP2	1.09e-04	7	68	2	EFO_0008150
Disease	renal tubular acidosis (implicated_via_orthology)	TCIRG1 ATP6V0A2	1.45e-04	8	68	2	DOID:14219 (implicated_via_orthology)
Disease	heterogeneous nuclear ribonucleoprotein q measurement	NLRP12 MED16	1.86e-04	9	68	2	EFO_0020443
Disease	ocular hypertension, response to triamcinolone acetonide	BRIP1 VWA8 OTOGL	2.00e-04	49	68	3	EFO_0006954, EFO_1001069
Disease	haptoglobin measurement	PMFBP1 PHLPP2	1.07e-03	21	68	2	EFO_0004640
Disease	Acute monocytic leukemia	BRIP1 KMT2A	1.64e-03	26	68	2	C0023465
Disease	corpus callosum central volume measurement	SLC9A4 LNX1	1.90e-03	28	68	2	EFO_0010296

Protein segments in the cluster

Peptide	Gene	Start	Entry
LPLDLACRVWDVFCR	TBC1D12	676	O60347
CLPLILRKTCCWINE	ADCY8	766	P40145
LSDCPELREIEWRCV	CHD8	931	Q9HCK8
LELRPAEWEKCLNLP	ADGRB3	1496	O60242
WCRPPQILRCDKIVE	CD300C	56	Q08708
EKLTDWQKLACLLCR	RBM10	751	P98175
LQLKELWIAECCIEK	LRRC9	76	Q6ZRR7
LWIAECCIEKIEGLQ	LRRC9	81	Q6ZRR7
ECRLDPADLQLLLDW	MON1B	296	Q7L1V2
LVSRICPNDVCRIWK	ANKRD13A	136	Q8IZ07
CDRLCPFWKLNITCE	ANO6	351	Q4KMQ2
ANLLCVWRRDVKPDC	MED13L	66	Q71F56
QCLRLEDCLATPRIW	NLRP8	791	Q86W28
DQCPCLCIKELWVLL	MMS22L	286	Q6ZRQ5
CALQEALWELKLDPD	LRRC3	151	Q9BY71
LCVPLTWRCDRDLDC	CD320	66	Q9NPF0
WLELPRCLYNCKDIV	LNX1	626	Q8TBB1
LDSNPLACDCRLLWV	LINGO1	366	Q96FE5
ELRCLLNKPEKDWTE	MICALL1	761	Q8N3F8
RLLKPECVLDKSWCQ	GCN1	926	Q92616
CEALRKPLCNLRCLW	NLRP2	946	Q9NX02
AVEKWLNDLLCLDCL	NAT10	476	Q9H0A0
RLLTKLWICCRDEGP	MED16	691	Q9Y2X0
EPLRAVCCSLINWLE	BRIP1	436	Q9BX63
CECTLGWLEPLLARI	GALNT13	211	Q8IUC8
LLNEELPNCWECPKC	KDM2A	661	Q9Y2K7
CARDPEIWRLACLKV	FBXO9	226	Q9UK97
LTELWKLKERCGDPC	B3GALNT2	481	Q8NCR0
CRLWDCETGKQLALL	EIF3I	76	Q13347
LIDLCILICWQAVDP	GABBR2	606	O75899
PLEDQLENWCCRRCK	KMT2A	1466	Q03164
SEQALWLLLPARCCL	HELZ2	441	Q9BYK8
ELLCQCLCQLEPRWL	HPS6	566	Q86YV9
NKELCILRNDWCSVP	DNA2	76	P51530
CDLFIPLDKLGLWRC	PEX11B	216	O96011
LPRDEIKLIENICWT	DSEL	1186	Q8IZU8
LCNKFDICIQWRTPD	OTOGL	1786	Q3ZCN5
QKRPLWLCKICSEQR	RPH3AL	131	Q9UNE2
NLLEDDKEPCCLPQW	PMFBP1	856	Q8TBY8
ECLCLWLDRERTCPL	RNFT2	406	Q96EX2
NCSCDLLPLKAWLEN	SLITRK4	216	Q8IW52
LREVNLWCPTLKVLC	SMARCAD1	561	Q9H4L7
CKELQELEPENKWCL	RABGGTA	371	Q92696
VLWKEILFLVDLICC	GPR108	396	Q9NPR9
PWNCLLLLVALECSE	SLC9A4	11	Q6AI14
WLGKRCALCRQEIPE	RNF146	66	Q9NTX7
EECWLRTLGAKKLCP	RNF220	536	Q5VTB9
KNCLRCWPELSALID	TEX51	16	A0A1B0GUA7
LWERATEKVACCPLE	NCAPD2	756	Q15021
SLLELEDWLQCPICL	TRIM74	6	Q86UV6
EDWLQCPICLEVFKE	TRIM74	11	Q86UV6
SLEEWKCLEPAQRDL	ZNF565	56	Q8N9K5
ACLSLCWLPRDQKLL	MIOS	186	Q9NXC5
RNLLECVPDWACEAK	PHLPP2	511	Q6ZVD8
LEASCWIPLLKARKC	IGHMBP2	381	P38935
CQWLRPEKCTKEQIL	SCAND2P	71	Q9GZW5
ALSRLRELCCQWLKP	ZNF165	66	P49910
PREALSQLRVLCCEW	ZNF232	66	Q9UNY5
SQLRVLCCEWLRPEK	ZNF232	71	Q9UNY5
LTVCWRLKPECLPLE	TMEM130	271	Q8N3G9
CASWRIPLDEINIIC	VWA8	1101	A3KMH1
LVLLIWEQLRKCCDS	VWA3A	981	A6NCI4
KCLIAEAWCSVRDLP	TCIRG1	316	Q13488
REEWLLDPSQKDLCR	ZKSCAN8	231	Q15776
ELCEPCWKLMRNLLG	TSC2	251	P49815
NKCLIAEVWCPEADL	ATP6V0A2	321	Q9Y487
LEKLPLQIDCLAAWE	VPS39	11	Q96JC1
LPDDCEILCGWRSLL	nan	56	Q8TCH9
LLSRWDKLDVCPLEE	ZSWIM4	361	Q9H7M6
CLCWEEKRPTELLLN	NLRP12	311	P59046
KCALERLELWFCQLA	NLRP13	866	Q86W25
CLDVNRDCLILTWAP	MYOM3	381	Q5VTT5