Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

ADRA1A HTR1D GPR18 ADGRG2 OR51I1 OR10AD1 SCN7A MC3R NTSR2 TAAR2 GPR183 GRPR CHRNA2 CHRNA3 CD200R1 CXCR1 OPRD1 CXCR2

1.45e-0813535618GO:0004888
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCC3 ABCA6 ABCC12 ATP13A3 ATP1A2 ATP1A3 ABCA8

2.21e-08109567GO:0042626
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCC3 ABCA6 RNF213 SRPRA ABCC12 ATP13A3 ATP1A2 ATP1A3 DNAH6 ATP8B2 ABCA8

3.28e-084415611GO:0016887
GeneOntologyMolecularFunctionG protein-coupled receptor activity

ADRA1A HTR1D GPR18 ADGRG2 OR51I1 OR10AD1 MC3R NTSR2 TAAR2 GPR183 GRPR CXCR1 OPRD1 CXCR2

1.03e-078845614GO:0004930
GeneOntologyMolecularFunctionATP-dependent activity

ABCC3 ABCA6 SLC27A6 RNF213 SRPRA ABCC12 ATP13A3 ATP1A2 ATP1A3 DNAH6 ATP8B2 ABCA8

1.04e-076145612GO:0140657
GeneOntologyMolecularFunctionABC-type transporter activity

ABCC3 ABCA6 ABCC12 ATP13A3 ABCA8

2.51e-0749565GO:0140359
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ABCC3 ABCA6 ABCC12 ATP13A3 ATP1A2 ATP1A3 ABCA8

6.38e-07178567GO:0015399
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ABCC3 ABCA6 RNF213 SRPRA ABCC12 ATP13A3 GNAT1 ATP1A2 ATP1A3 DNAH6 ATP8B2 ABCA8

1.24e-067755612GO:0017111
GeneOntologyMolecularFunctionpyrophosphatase activity

ABCC3 ABCA6 RNF213 SRPRA ABCC12 ATP13A3 GNAT1 ATP1A2 ATP1A3 DNAH6 ATP8B2 ABCA8

2.84e-068395612GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ABCC3 ABCA6 RNF213 SRPRA ABCC12 ATP13A3 GNAT1 ATP1A2 ATP1A3 DNAH6 ATP8B2 ABCA8

2.87e-068405612GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ABCC3 ABCA6 RNF213 SRPRA ABCC12 ATP13A3 GNAT1 ATP1A2 ATP1A3 DNAH6 ATP8B2 ABCA8

2.87e-068405612GO:0016818
GeneOntologyMolecularFunctioninterleukin-8 receptor activity

CXCR1 CXCR2

7.73e-062562GO:0004918
GeneOntologyMolecularFunctiontransporter activity

ABCC3 ABCA6 SLC27A6 TRPC4 SCN7A TMEM184C ABCC12 ATP13A3 ATP1A2 ATP1A3 ATP8B2 CHRNA2 ABCA8 CHRNA3

9.09e-0612895614GO:0005215
GeneOntologyMolecularFunctioninterleukin-8 binding

CXCR1 CXCR2

2.31e-053562GO:0019959
GeneOntologyMolecularFunctiontransmembrane transporter activity

ABCC3 ABCA6 SLC27A6 TRPC4 SCN7A ABCC12 ATP13A3 ATP1A2 ATP1A3 CHRNA2 ABCA8 CHRNA3

8.49e-0511805612GO:0022857
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP13A3 ATP1A2 ATP1A3

1.40e-0436563GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP13A3 ATP1A2 ATP1A3

1.40e-0436563GO:0015662
GeneOntologyMolecularFunctionneuropeptide binding

MC3R GRPR OPRD1

1.52e-0437563GO:0042923
GeneOntologyMolecularFunctionC-X-C chemokine binding

CXCR1 CXCR2

1.61e-047562GO:0019958
GeneOntologyMolecularFunctionsteroid hormone binding

ATP1A2 ATP1A3

1.61e-047562GO:1990239
GeneOntologyMolecularFunctionG protein-coupled amine receptor activity

ADRA1A HTR1D TAAR2

2.07e-0441563GO:0008227
GeneOntologyMolecularFunctionC-X-C chemokine receptor activity

CXCR1 CXCR2

2.14e-048562GO:0016494
GeneOntologyMolecularFunctionlipid transporter activity

ABCC3 ABCA6 SLC27A6 ATP8B2 ABCA8

2.20e-04196565GO:0005319
GeneOntologyMolecularFunctionP-type sodium transporter activity

ATP1A2 ATP1A3

3.43e-0410562GO:0008554
GeneOntologyMolecularFunctionP-type sodium:potassium-exchanging transporter activity

ATP1A2 ATP1A3

3.43e-0410562GO:0005391
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCC3 ABCA6 ABCC12 ATP13A3 ATP1A2 ATP1A3 ABCA8

3.58e-04477567GO:0022804
GeneOntologyMolecularFunctionP-type potassium transmembrane transporter activity

ATP1A2 ATP1A3

4.18e-0411562GO:0008556
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

MC3R NTSR2 GRPR OPRD1

5.28e-04133564GO:0008528
GeneOntologyMolecularFunctionsteroid binding

SYP GPR183 ATP1A2 ATP1A3

5.28e-04133564GO:0005496
GeneOntologyMolecularFunctionpeptide receptor activity

MC3R NTSR2 GRPR OPRD1

6.41e-04140564GO:0001653
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP13A3 ATP1A2 ATP1A3

7.03e-0462563GO:0019829
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCC3 ABCA8

7.92e-0415562GO:0008559
GeneOntologyMolecularFunctionacetylcholine-gated monoatomic cation-selective channel activity

CHRNA2 CHRNA3

1.02e-0317562GO:0022848
GeneOntologyMolecularFunctionprotein binding involved in heterotypic cell-cell adhesion

CD47 CD200R1

1.15e-0318562GO:0086080
GeneOntologyMolecularFunctionacetylcholine receptor activity

CHRNA2 CHRNA3

1.88e-0323562GO:0015464
GeneOntologyMolecularFunctionC-C chemokine receptor activity

CXCR1 CXCR2

1.88e-0323562GO:0016493
GeneOntologyMolecularFunctionantigen binding

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

1.98e-03190564GO:0003823
GeneOntologyMolecularFunctionC-C chemokine binding

CXCR1 CXCR2

2.05e-0324562GO:0019957
GeneOntologyMolecularFunctionG protein-coupled chemoattractant receptor activity

CXCR1 CXCR2

2.40e-0326562GO:0001637
GeneOntologyMolecularFunctionchemokine receptor activity

CXCR1 CXCR2

2.40e-0326562GO:0004950
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

TRPC4 SCN7A ATP13A3 ATP1A2 ATP1A3 CHRNA2 CHRNA3

2.46e-03664567GO:0008324
GeneOntologyMolecularFunctionmannosyltransferase activity

TMTC4 DPY19L1

2.79e-0328562GO:0000030
GeneOntologyMolecularFunctionneurotransmitter receptor activity

HTR1D CHRNA2 CHRNA3

2.79e-03100563GO:0030594
GeneOntologyMolecularFunctionhormone binding

MC3R ATP1A2 ATP1A3

3.03e-03103563GO:0042562
GeneOntologyMolecularFunctionchemokine binding

CXCR1 CXCR2

3.86e-0333562GO:0019956
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

ABCC3 ABCA8

4.09e-0334562GO:0042910
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

TRPC4 SCN7A ATP13A3 ATP1A2 ATP1A3 CHRNA2 CHRNA3

6.48e-03793567GO:0015075
GeneOntologyMolecularFunctionexcitatory extracellular ligand-gated monoatomic ion channel activity

CHRNA2 CHRNA3

6.48e-0343562GO:0005231
GeneOntologyMolecularFunctionneuropeptide receptor activity

NTSR2 GRPR

9.71e-0353562GO:0008188
GeneOntologyMolecularFunctionimmune receptor activity

CD200R1 CXCR1 CXCR2

1.11e-02165563GO:0140375
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

CHRNA2 CHRNA3

1.12e-0257562GO:1904315
GeneOntologyMolecularFunctionpeptide binding

MC3R ATP1A3 GRPR OPRD1

1.21e-02318564GO:0042277
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN7A ATP1A2 ATP1A3

1.23e-02171563GO:0015081
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

CHRNA2 CHRNA3

1.23e-0260562GO:0099529
GeneOntologyMolecularFunctioncell-cell adhesion mediator activity

CD47 CD200R1

1.27e-0261562GO:0098632
GeneOntologyMolecularFunctiontransmitter-gated channel activity

CHRNA2 CHRNA3

1.44e-0265562GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

CHRNA2 CHRNA3

1.44e-0265562GO:0022824
GeneOntologyBiologicalProcessphospholipase C-activating G protein-coupled receptor signaling pathway

ADRA1A GPR18 MC3R NTSR2 GRPR OPRD1 CXCR2

7.05e-08133567GO:0007200
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

ADRA1A HTR1D GPR18 ADGRG2 OR51I1 OR10AD1 MC3R NTSR2 TAAR2 SYP C5 GPR183 GNAT1 GRPR CXCR1 OPRD1 CXCR2

9.19e-0813955617GO:0007186
GeneOntologyBiologicalProcessinterleukin-8-mediated signaling pathway

CXCR1 CXCR2

7.24e-062562GO:0038112
GeneOntologyBiologicalProcesssodium ion homeostasis

SCN7A MC3R ATP1A2 ATP1A3

1.11e-0551564GO:0055078
GeneOntologyBiologicalProcessregulation of membrane potential

ADRA1A TRPC4 SCN7A NTSR2 ATP1A2 ATP1A3 CHRNA2 CHRNA3 OPRD1

1.80e-05559569GO:0042391
GeneOntologyBiologicalProcessresponse to nicotine

ATP1A2 CHRNA2 CHRNA3 OPRD1

1.85e-0558564GO:0035094
GeneOntologyBiologicalProcesscellular response to interleukin-8

CXCR1 CXCR2

2.17e-053562GO:0098759
GeneOntologyBiologicalProcessresponse to interleukin-8

CXCR1 CXCR2

2.17e-053562GO:0098758
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

HTR1D MC3R GNAT1 OPRD1

2.27e-0561564GO:0007187
GeneOntologyBiologicalProcessleukocyte migration

GPR18 CD47 C5 GPR183 ITGA3 CD200R1 CXCR1 CXCR2

2.69e-05449568GO:0050900
GeneOntologyBiologicalProcessimmunoglobulin mediated immune response

IGHV3-38 IGHV3-16 IGHV3-11 C5 TP53BP1 IGHV3-64

4.14e-05235566GO:0016064
GeneOntologyBiologicalProcessB cell mediated immunity

IGHV3-38 IGHV3-16 IGHV3-11 C5 TP53BP1 IGHV3-64

5.10e-05244566GO:0019724
GeneOntologyBiologicalProcessdendritic cell chemotaxis

GPR183 CXCR1 CXCR2

6.59e-0529563GO:0002407
GeneOntologyBiologicalProcessmononuclear cell migration

CD47 C5 GPR183 CD200R1 CXCR1 CXCR2

6.95e-05258566GO:0071674
GeneOntologyBiologicalProcessresponse to glycoside

ATP1A2 ATP1A3

7.20e-055562GO:1903416
GeneOntologyBiologicalProcessintracellular sodium ion homeostasis

SCN7A ATP1A2 ATP1A3

7.31e-0530563GO:0006883
GeneOntologyBiologicalProcessadenylate cyclase-modulating G protein-coupled receptor signaling pathway

ADRA1A HTR1D ADGRG2 MC3R GNAT1 OPRD1

1.22e-04286566GO:0007188
GeneOntologyBiologicalProcessdendritic cell migration

GPR183 CXCR1 CXCR2

1.27e-0436563GO:0036336
GeneOntologyBiologicalProcessmonoatomic ion transport

ABCC3 ADRA1A TRPC4 SCN7A NDFIP2 ATP13A3 ATP1A2 ATP1A3 ATP8B2 CHRNA2 CHRNA3 OPRD1

2.62e-0413745612GO:0006811
GeneOntologyBiologicalProcessmembrane depolarization

ATP1A2 ATP1A3 CHRNA2 CHRNA3

3.27e-04121564GO:0051899
GeneOntologyBiologicalProcessestablishment or maintenance of transmembrane electrochemical gradient

ATP1A2 ATP1A3

3.92e-0411562GO:0010248
GeneOntologyBiologicalProcesssmooth muscle contraction

ADRA1A HTR1D ATP1A2 CHRNA3

4.68e-04133564GO:0006939
GeneOntologyBiologicalProcessimmune effector process

IGHV3-38 IGHV3-16 IGHV3-11 CD37 CD47 C5 GPR183 TP53BP1 IGHV3-64

4.71e-04859569GO:0002252
GeneOntologyBiologicalProcessnegative regulation of leukocyte migration

GPR18 C5 CD200R1

5.53e-0459563GO:0002686
GeneOntologyBiologicalProcessG protein-coupled opioid receptor signaling pathway

SYP OPRD1

5.54e-0413562GO:0038003
GeneOntologyBiologicalProcessregulation of neurotransmitter transport

HTR1D SYP ATP1A2 CHRNA3

5.83e-04141564GO:0051588
GeneOntologyBiologicalProcessbehavior

HTR1D MC3R ITGA3 GNAT1 ATP1A2 ATP1A3 GRPR CHRNA3 OPRD1

6.14e-04891569GO:0007610
GeneOntologyBiologicalProcessmuscle contraction

ADRA1A HTR1D SCN7A ATP1A2 ATP1A3 CHRNA3

7.34e-04400566GO:0006936
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

ABCC3 ADRA1A TRPC4 SCN7A ATP13A3 ATP1A2 ATP1A3 ATP8B2 CHRNA2 CHRNA3

7.51e-0411155610GO:0034220
GeneOntologyBiologicalProcessfear response

ATP1A2 ATP1A3 GRPR

7.68e-0466563GO:0042596
GeneOntologyBiologicalProcesscirculatory system process

ABCC3 ADRA1A HTR1D SCN7A MC3R ATP1A2 ATP1A3 CXCR2

7.69e-04733568GO:0003013
GeneOntologyBiologicalProcessregulation of leukocyte migration

GPR18 CD47 C5 CD200R1 CXCR2

7.80e-04267565GO:0002685
GeneOntologyBiologicalProcessleukocyte chemotaxis

GPR18 C5 GPR183 CXCR1 CXCR2

7.80e-04267565GO:0030595
GeneOntologyBiologicalProcessL-ascorbic acid metabolic process

ATP1A2 ATP1A3

8.48e-0416562GO:0019852
GeneOntologyBiologicalProcessnegative regulation of macrophage migration

C5 CD200R1

8.48e-0416562GO:1905522
GeneOntologyBiologicalProcessmyeloid leukocyte migration

CD47 C5 CD200R1 CXCR1 CXCR2

9.05e-04276565GO:0097529
GeneOntologyBiologicalProcessintracellular potassium ion homeostasis

ATP1A2 ATP1A3

9.59e-0417562GO:0030007
GeneOntologyBiologicalProcesssodium ion export across plasma membrane

ATP1A2 ATP1A3

9.59e-0417562GO:0036376
GeneOntologyBiologicalProcesslocomotory behavior

MC3R ATP1A2 ATP1A3 CHRNA3 OPRD1

1.03e-03284565GO:0007626
GeneOntologyBiologicalProcesscardiac muscle contraction

ADRA1A SCN7A ATP1A2 ATP1A3

1.10e-03167564GO:0060048
GeneOntologyBiologicalProcessxenobiotic transmembrane transport

ABCC3 ABCA8

1.20e-0319562GO:0006855
GeneOntologyBiologicalProcesslactone metabolic process

ATP1A2 ATP1A3

1.20e-0319562GO:1901334
GeneOntologyBiologicalProcessheart contraction

ADRA1A SCN7A MC3R ATP1A2 ATP1A3

1.27e-03298565GO:0060047
GeneOntologyBiologicalProcessregulation of smooth muscle contraction

ADRA1A ATP1A2 CHRNA3

1.30e-0379563GO:0006940
GeneOntologyBiologicalProcesslymphocyte mediated immunity

IGHV3-38 IGHV3-16 IGHV3-11 C5 TP53BP1 IGHV3-64

1.33e-03449566GO:0002449
GeneOntologyBiologicalProcessinorganic ion homeostasis

TMTC4 TRPC4 SCN7A MC3R ATP13A3 ATP1A2 ATP1A3

1.41e-03622567GO:0098771
GeneOntologyBiologicalProcessresponse to potassium ion

ATP1A2 ATP1A3

1.47e-0321562GO:0035864
GeneOntologyBiologicalProcessheart process

ADRA1A SCN7A MC3R ATP1A2 ATP1A3

1.49e-03309565GO:0003015
GeneOntologyBiologicalProcessadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

IGHV3-38 IGHV3-16 IGHV3-11 C5 TP53BP1 IGHV3-64

1.54e-03462566GO:0002460
GeneOntologyBiologicalProcessregulation of short-term neuronal synaptic plasticity

SYP ATP1A3

1.62e-0322562GO:0048172
GeneOntologyBiologicalProcessvisual behavior

GNAT1 ATP1A2 ATP1A3

1.65e-0386563GO:0007632
GeneOntologyBiologicalProcessnegative regulation of leukocyte chemotaxis

GPR18 C5

1.77e-0323562GO:0002689
GeneOntologyBiologicalProcessblood circulation

ADRA1A HTR1D SCN7A MC3R ATP1A2 ATP1A3 CXCR2

1.78e-03648567GO:0008015
GeneOntologyBiologicalProcessadenylate cyclase-activating G protein-coupled receptor signaling pathway

ADRA1A ADGRG2 MC3R OPRD1

1.80e-03191564GO:0007189
GeneOntologyCellularComponentsynaptic membrane

ADRA1A SYP FLRT3 ITGA3 ATP1A3 CHRNA2 CHRNA3 OPRD1

1.52e-04583568GO:0097060
GeneOntologyCellularComponentdistal axon

GDPD5 SYP FLRT3 ITGA3 NRSN1 ATP1A3 OPRD1

1.55e-04435567GO:0150034
GeneOntologyCellularComponentsodium:potassium-exchanging ATPase complex

ATP1A2 ATP1A3

4.57e-0412562GO:0005890
GeneOntologyCellularComponenttransporter complex

TRPC4 SCN7A ATP1A2 ATP1A3 ATP8B2 CHRNA2 CHRNA3

6.38e-04550567GO:1990351
GeneOntologyCellularComponentplasma membrane raft

ADRA1A TRPC4 ATP1A2 CHRNA3

6.49e-04147564GO:0044853
GeneOntologyCellularComponentcell surface

ADGRG2 TRPC4 CD47 NTSR2 ITGA3 ATP1A2 ATP1A3 CD200R1 CXCR1 CXCR2

6.59e-0411115610GO:0009986
GeneOntologyCellularComponentpostsynaptic membrane

ADRA1A FLRT3 ITGA3 CHRNA2 CHRNA3 OPRD1

7.30e-04405566GO:0045211
GeneOntologyCellularComponentpresynaptic membrane

ADRA1A SYP ITGA3 ATP1A3 OPRD1

8.67e-04277565GO:0042734
GeneOntologyCellularComponentimmunoglobulin complex

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

1.02e-03166564GO:0019814
GeneOntologyCellularComponentacetylcholine-gated channel complex

CHRNA2 CHRNA3

1.05e-0318562GO:0005892
GeneOntologyCellularComponentplasma membrane protein complex

SCN7A C5 ITGA3 GNAT1 ATP1A2 ATP1A3 CHRNA2 CHRNA3

1.10e-03785568GO:0098797
GeneOntologyCellularComponentpostsynapse

ADRA1A SYP FLRT3 ITGA3 ATP1A2 ATP1A3 CHRNA2 CHRNA3 OPRD1

1.43e-031018569GO:0098794
GeneOntologyCellularComponentdopaminergic synapse

ADRA1A CHRNA3

1.57e-0322562GO:0098691
GeneOntologyCellularComponentsarcolemma

ADRA1A SLC27A6 ATP1A2 ATP1A3

1.68e-03190564GO:0042383
GeneOntologyCellularComponentaxon terminus

SYP FLRT3 ATP1A3 OPRD1

2.42e-03210564GO:0043679
GeneOntologyCellularComponenttransmembrane transporter complex

TRPC4 SCN7A ATP1A2 ATP1A3 CHRNA2 CHRNA3

2.68e-03523566GO:1902495
GeneOntologyCellularComponentcaveola

ADRA1A TRPC4 ATP1A2

3.29e-03111563GO:0005901
GeneOntologyCellularComponentneuron projection terminus

SYP FLRT3 ATP1A3 OPRD1

3.51e-03233564GO:0044306
GeneOntologyCellularComponentneuronal dense core vesicle

HTR1D OPRD1

4.19e-0336562GO:0098992
GeneOntologyCellularComponentgrowth cone

GDPD5 FLRT3 ITGA3 NRSN1

4.20e-03245564GO:0030426
GeneOntologyCellularComponentneuron spine

SYP ATP1A2 ATP1A3 OPRD1

4.32e-03247564GO:0044309
GeneOntologyCellularComponentsite of polarized growth

GDPD5 FLRT3 ITGA3 NRSN1

4.70e-03253564GO:0030427
GeneOntologyCellularComponentsomatodendritic compartment

GDPD5 HTR1D NTSR2 GNAT1 ATP1A2 NRSN1 ATP1A3 CHRNA3 OPRD1

5.04e-031228569GO:0036477
HumanPhenoEpisodic quadriplegia

ATP1A2 ATP1A3

8.09e-062152HP:0200072
HumanPhenoEpisodic hemiplegia

ATP1A2 ATP1A3

4.84e-054152HP:0012194
HumanPhenoSkewfoot

ATP1A2 ATP1A3

1.21e-046152HP:0032649
HumanPhenoOcular flutter

ATP1A2 ATP1A3

1.21e-046152HP:0031931
Domain7TM_GPCR_Srsx

ADRA1A HTR1D OR51I1 MC3R TAAR2 GPR183 GRPR OPRD1

7.84e-10112528SM01381
DomainGPCR_Rhodpsn_7TM

ADRA1A HTR1D GPR18 OR51I1 OR10AD1 MC3R NTSR2 TAAR2 GPR183 GRPR CXCR1 OPRD1 CXCR2

2.54e-086705213IPR017452
Domain7tm_1

ADRA1A HTR1D GPR18 OR51I1 OR10AD1 MC3R NTSR2 TAAR2 GPR183 GRPR CXCR1 OPRD1 CXCR2

2.87e-086775213PF00001
DomainG_PROTEIN_RECEP_F1_1

ADRA1A HTR1D GPR18 OR51I1 OR10AD1 MC3R NTSR2 TAAR2 GPR183 GRPR CXCR1 OPRD1 CXCR2

3.29e-086855213PS00237
DomainG_PROTEIN_RECEP_F1_2

ADRA1A HTR1D GPR18 OR51I1 OR10AD1 MC3R NTSR2 TAAR2 GPR183 GRPR CXCR1 OPRD1 CXCR2

3.65e-086915213PS50262
DomainGPCR_Rhodpsn

ADRA1A HTR1D GPR18 OR51I1 OR10AD1 MC3R NTSR2 TAAR2 GPR183 GRPR CXCR1 OPRD1 CXCR2

3.71e-086925213IPR000276
DomainAAA+_ATPase

ABCC3 ABCA6 RNF213 SRPRA ABCC12 DNAH6 ABCA8

1.40e-07144527IPR003593
DomainAAA

ABCC3 ABCA6 RNF213 SRPRA ABCC12 DNAH6 ABCA8

1.40e-07144527SM00382
Domain-

ATP13A3 ATP1A2 ATP1A3 ATP8B2

1.81e-06325242.70.150.10
Domain-

ATP13A3 ATP1A2 ATP1A3 ATP8B2

1.81e-06325243.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP13A3 ATP1A2 ATP1A3 ATP8B2

2.62e-0635524IPR023299
DomainATPase_P-typ_P_site

ATP13A3 ATP1A2 ATP1A3 ATP8B2

2.95e-0636524IPR018303
DomainP_typ_ATPase

ATP13A3 ATP1A2 ATP1A3 ATP8B2

2.95e-0636524IPR001757
DomainATPASE_E1_E2

ATP13A3 ATP1A2 ATP1A3 ATP8B2

2.95e-0636524PS00154
DomainATPase_P-typ_transduc_dom_A

ATP13A3 ATP1A2 ATP1A3 ATP8B2

3.30e-0637524IPR008250
DomainE1-E2_ATPase

ATP13A3 ATP1A2 ATP1A3 ATP8B2

3.30e-0637524PF00122
DomainChemokine_CXCR_1/2

CXCR1 CXCR2

7.60e-062522IPR000174
DomainABC_TRANSPORTER_2

ABCC3 ABCA6 ABCC12 ABCA8

9.49e-0648524PS50893
DomainABC_tran

ABCC3 ABCA6 ABCC12 ABCA8

9.49e-0648524PF00005
DomainABC_TRANSPORTER_1

ABCC3 ABCA6 ABCC12 ABCA8

1.03e-0549524PS00211
DomainABC_transporter-like

ABCC3 ABCA6 ABCC12 ABCA8

1.12e-0550524IPR003439
DomainATPase_P-typ_cation-transptr_C

ATP13A3 ATP1A2 ATP1A3

1.35e-0517523IPR006068
DomainCation_ATPase_C

ATP13A3 ATP1A2 ATP1A3

1.35e-0517523PF00689
DomainCation_ATPase_N

ATP13A3 ATP1A2 ATP1A3

1.61e-0518523PF00690
DomainATPase_P-typ_cation-transptr_N

ATP13A3 ATP1A2 ATP1A3

1.91e-0519523IPR004014
DomainHAD-like_dom

ATP13A3 ATP1A2 ATP1A3 ATP8B2

6.88e-0579524IPR023214
DomainP-type_ATPase_IIC

ATP1A2 ATP1A3

1.13e-046522IPR005775
DomainCXCR4/ACKR2

CXCR1 CXCR2

1.58e-047522IPR001277
DomainABC_A

ABCA6 ABCA8

4.93e-0412522IPR026082
Domain-

ATP1A2 ATP1A3

8.90e-04165221.20.1110.10
DomainNicotinic_acetylcholine_rcpt

CHRNA2 CHRNA3

8.90e-0416522IPR002394
DomainATPase_P-typ_TM_dom

ATP1A2 ATP1A3

8.90e-0416522IPR023298
Domain-

ABCC3 ABCA6 RNF213 SRPRA ABCC12 GNAT1 DNAH6 ABCA8

9.90e-047465283.40.50.300
DomainCation_ATPase_N

ATP1A2 ATP1A3

1.13e-0318522SM00831
DomainAcetylcholine_rcpt_TM

CHRNA2 CHRNA3

1.85e-0323522IPR027361
Domain-

CHRNA2 CHRNA3

1.85e-03235221.20.120.370
DomainABC_membrane

ABCC3 ABCC12

2.02e-0324522PF00664
DomainP-loop_NTPase

ABCC3 ABCA6 RNF213 SRPRA ABCC12 GNAT1 DNAH6 ABCA8

2.23e-03848528IPR027417
DomainABC_TM1F

ABCC3 ABCC12

2.74e-0328522PS50929
DomainABC1_TM_dom

ABCC3 ABCC12

2.74e-0328522IPR011527
DomainABC_transporter_CS

ABCC3 ABCC12

6.10e-0342522IPR017871
DomainNeurotransmitter_ion_chnl_CS

CHRNA2 CHRNA3

6.97e-0345522IPR018000
DomainNeur_chan_memb

CHRNA2 CHRNA3

7.28e-0346522PF02932
DomainNeur_chan_LBD

CHRNA2 CHRNA3

7.59e-0347522PF02931
DomainNeur_channel

CHRNA2 CHRNA3

7.59e-0347522IPR006201
DomainNeur_chan_lig-bd

CHRNA2 CHRNA3

7.59e-0347522IPR006202
DomainNEUROTR_ION_CHANNEL

CHRNA2 CHRNA3

7.59e-0347522PS00236
DomainNeurotrans-gated_channel_TM

CHRNA2 CHRNA3

7.59e-0347522IPR006029
Domain-

CHRNA2 CHRNA3

7.59e-03475222.70.170.10
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

ADRA1A HTR1D GPR18 MC3R NTSR2 TAAR2 C5 GPR183 GRPR CXCR1 OPRD1 CXCR2

2.39e-103304412M18334
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

ADRA1A HTR1D GPR18 MC3R NTSR2 TAAR2 C5 GPR183 GRPR CXCR1 OPRD1 CXCR2

2.65e-103334412MM14963
PathwayREACTOME_GPCR_LIGAND_BINDING

ADRA1A HTR1D GPR18 MC3R NTSR2 TAAR2 C5 GPR183 GRPR CXCR1 OPRD1 CXCR2

4.85e-094304412MM15160
PathwayWP_GPCRS_NONODORANT

ADRA1A HTR1D GPR18 ADGRG2 MC3R NTSR2 GRPR CXCR1 OPRD1 CXCR2

6.82e-092664410MM15843
PathwayREACTOME_GPCR_LIGAND_BINDING

ADRA1A HTR1D GPR18 MC3R NTSR2 TAAR2 C5 GPR183 GRPR CXCR1 OPRD1 CXCR2

1.11e-084634412M507
PathwayREACTOME_SIGNALING_BY_GPCR

ADRA1A HTR1D GPR18 MC3R NTSR2 TAAR2 C5 GPR183 GNAT1 GRPR CXCR1 OPRD1 CXCR2

4.86e-086464413MM14962
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

ADRA1A HTR1D GPR18 MC3R NTSR2 GRPR CXCR1 OPRD1 CXCR2

8.67e-08260449M39397
PathwayWP_PEPTIDE_GPCRS

MC3R NTSR2 GRPR CXCR1 OPRD1 CXCR2

1.11e-0775446M39696
PathwayKEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION

ADRA1A HTR1D MC3R NTSR2 TAAR2 GRPR CHRNA2 CHRNA3 OPRD1

1.28e-07272449M13380
PathwayREACTOME_SIGNALING_BY_GPCR

ADRA1A HTR1D GPR18 MC3R NTSR2 TAAR2 C5 GPR183 GNAT1 GRPR CXCR1 OPRD1 CXCR2

1.28e-077024413M746
PathwayWP_GPCRS_OTHER

GPR18 TAAR2 GPR183 GRPR CXCR1 CXCR2

4.04e-0793446M39629
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

ADRA1A HTR1D MC3R NTSR2 GRPR OPRD1 CXCR2

1.58e-06186447MM15994
PathwayREACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS

MC3R NTSR2 C5 GRPR CXCR1 OPRD1 CXCR2

2.31e-06197447M12289
PathwayREACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS

MC3R NTSR2 C5 GRPR CXCR1 OPRD1 CXCR2

2.31e-06197447MM14970
PathwayWP_GPCRS_PEPTIDE

MC3R NTSR2 GRPR OPRD1 CXCR2

2.44e-0670445MM15959
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

HTR1D GPR18 C5 GPR183 GNAT1 CXCR1 OPRD1 CXCR2

2.64e-06289448MM15057
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

HTR1D GPR18 C5 GPR183 GNAT1 CXCR1 OPRD1 CXCR2

4.89e-06314448M600
PathwayKEGG_ABC_TRANSPORTERS

ABCC3 ABCA6 ABCC12 ABCA8

1.02e-0544444M11911
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

ADRA1A HTR1D TAAR2

2.99e-0442443M5868
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

ADRA1A HTR1D TAAR2

2.99e-0442443MM14971
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA3

3.38e-049442M27597
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA3

3.38e-049442MM15313
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA3

5.14e-0411442M883
PathwayREACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA3

6.16e-0412442M48008
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA3

6.16e-0412442MM15312
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP1A2 ATP1A3 ATP8B2

6.65e-0455443M971
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP1A2 ATP1A3 ATP8B2

7.38e-0457443MM15643
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRNA2 CHRNA3

8.46e-0414442M757
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRNA2 CHRNA3

9.74e-0415442MM14704
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ABCC3 ABCA6 SLC27A6 TRPC4 ATP1A2 ATP1A3 ATP8B2 ABCA8

1.08e-03681448MM14985
PathwayREACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL

IGHV3-11 CD47 ITGA3 IGHV3-64

1.45e-03158444MM14812
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ABCC3 ABCA6 SLC27A6 TRPC4 ATP1A2 ATP1A3 ATP8B2 ABCA8

1.77e-03736448M27287
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPC4 ATP1A2 ATP1A3 ATP8B2

2.16e-03176444MM15718
PathwayREACTOME_COMPLEMENT_CASCADE

IGHV3-11 C5 IGHV3-64

2.27e-0384443MM14653
PathwayKEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION

ATP1A2 ATP1A3

2.31e-0323442M4361
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPC4 ATP1A2 ATP1A3 ATP8B2

2.49e-03183444M997
PathwayREACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT

ABCC3 ABCA6 ABCA8

3.61e-0399443MM14986
PathwayREACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT

ABCC3 ABCA6 ABCA8

4.04e-03103443M758
PathwayWP_MONOAMINE_GPCRS

ADRA1A HTR1D

4.18e-0331442MM15871
PathwayWP_MONOAMINE_GPCRS

ADRA1A HTR1D

4.73e-0333442M39585
Pubmed

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.

ADRA1A HTR1D TAAR2 C5 GNAT1 GRPR CXCR1 OPRD1 CXCR2

3.44e-1120056918240029
Pubmed

The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities.

ADRA1A CXCR1 CXCR2

3.95e-09356315946947
Pubmed

The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.

SYP ATP1A2 ATP1A3

1.58e-08456312458206
Pubmed

Dissociation of heterotrimeric g proteins in cells.

HTR1D GPR18 MC3R CXCR1 OPRD1 CXCR2

4.48e-0717956618577758
Pubmed

Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus.

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

4.75e-07395648490662
Pubmed

Effects of CXCR1 and CXCR2 inhibition on expansion and differentiation of umbilical cord blood CD133(+) cells into megakaryocyte progenitor cells.

CXCR1 CXCR2

2.55e-06256221555225
Pubmed

Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion.

CXCR1 CXCR2

2.55e-06256219585580
Pubmed

CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury.

CXCR1 CXCR2

2.55e-06256221254176
Pubmed

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer.

OPRD1 CXCR2

2.55e-06256218307412
Pubmed

Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor.

CXCR1 CXCR2

2.55e-06256230218547
Pubmed

Collagen-Derived N-Acetylated Proline-Glycine-Proline in Intervertebral Discs Modulates CXCR1/2 Expression and Activation in Cartilage Endplate Stem Cells to Induce Migration and Differentiation Toward a Pro-Inflammatory Phenotype.

CXCR1 CXCR2

2.55e-06256226302999
Pubmed

Elevated expression of the interleukin-8 receptors CXCR1 and CXCR2 in peripheral blood cells in obstructive coronary artery disease.

CXCR1 CXCR2

2.55e-06256221915051
Pubmed

The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature.

CXCR1 CXCR2

2.55e-06256218668539
Pubmed

Expression of CXCR-1 and CXCR-2 chemokine receptors on synovial neutrophils in inflammatory arthritides: does persistent or increasing expression of CXCR-2 contribute to the chronic inflammation or erosive changes?

CXCR1 CXCR2

2.55e-06256216987681
Pubmed

Bronchoepithelial expression of CXCR1 and CXCR2 does not facilitate transepithelial migration of neutrophils.

CXCR1 CXCR2

2.55e-06256222076427
Pubmed

Intracellular trafficking of human CXCR1 and CXCR2: regulation by receptor domains and actin-related kinases.

CXCR1 CXCR2

2.55e-06256212442335
Pubmed

Identification and profiling of novel α1A-adrenoceptor-CXC chemokine receptor 2 heteromer.

ADRA1A CXCR2

2.55e-06256222371491
Pubmed

Roles of mechanical force and CXCR1/CXCR2 in shear-stress-induced endothelial cell migration.

CXCR1 CXCR2

2.55e-06256221989491
Pubmed

Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.

CXCR1 CXCR2

2.55e-06256230341468
Pubmed

Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.

CXCR1 CXCR2

2.55e-0625627929358
Pubmed

CXCR1 and CXCR2 are novel mechano-sensors mediating laminar shear stress-induced endothelial cell migration.

CXCR1 CXCR2

2.55e-06256221036625
Pubmed

ATP1A2- and ATP1A3-associated early profound epileptic encephalopathy and polymicrogyria.

ATP1A2 ATP1A3

2.55e-06256233880529
Pubmed

[Effects of Xiaotan Sanjie Decoction on expressions of interleukin-8 and its receptors in gastric tumor xenografts and gastric tissue adjacent to the tumor in mice].

CXCR1 CXCR2

2.55e-06256220082763
Pubmed

The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist.

CXCR1 CXCR2

2.55e-06256220044480
Pubmed

CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.

CXCR1 CXCR2

2.55e-06256226791948
Pubmed

Interleukin-8 in the human fallopian tube.

CXCR1 CXCR2

2.55e-06256211397869
Pubmed

Expression of interleukin-8 receptors in endometriosis.

CXCR1 CXCR2

2.55e-06256215618253
Pubmed

The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.

ATP1A2 ATP1A3

2.55e-06256218957371
Pubmed

Intracellular cross-talk between the GPCR CXCR1 and CXCR2: role of carboxyl terminus phosphorylation sites.

CXCR1 CXCR2

2.55e-06256217996233
Pubmed

On the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2.

CXCR1 CXCR2

2.55e-06256215028716
Pubmed

Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.

HTR1D OPRD1

2.55e-06256212740597
Pubmed

CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion.

CXCR1 CXCR2

2.55e-06256219401689
Pubmed

Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma.

CXCR1 CXCR2

2.55e-06256215772681
Pubmed

A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients.

CXCR1 CXCR2

2.55e-06256217360650
Pubmed

Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India.

CXCR1 CXCR2

2.55e-06256222171941
Pubmed

Low expression of CXCR1/2 on neutrophils predicts poor survival in patients with hepatitis B virus-related acute-on-chronic liver failure.

CXCR1 CXCR2

2.55e-06256227974825
Pubmed

Association between interleukin 8-receptor gene (CXCR1 and CXCR2) polymorphisms and urinary tract infection: Evidence from 4097 subjects.

CXCR1 CXCR2

2.55e-06256229577511
Pubmed

Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.

CXCR1 CXCR2

2.55e-0625628384312
Pubmed

Association of CXCR1 and 2 expressions with gastric cancer metastasis in ex vivo and tumor cell invasion in vitro.

CXCR1 CXCR2

2.55e-06256225022956
Pubmed

Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump.

ITGA3 ATP1A3

2.55e-06256228472154
Pubmed

Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa.

HTR1D OPRD1

2.55e-06256216806108
Pubmed

Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells.

CXCR1 CXCR2

2.55e-0625627829970
Pubmed

CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.

CXCR1 CXCR2

2.55e-06256226087179
Pubmed

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration.

CXCR1 CXCR2

2.55e-06256222152684
Pubmed

[Diagnostic efficiency of determining CXCR1, CXCR2 and hyaluronic acid blood level in non-small cell lung cancer patients].

CXCR1 CXCR2

2.55e-06256234730557
Pubmed

Phagocytosing neutrophils down-regulate the expression of chemokine receptors CXCR1 and CXCR2.

CXCR1 CXCR2

2.55e-06256212239185
Pubmed

Regulation of CXCR/IL-8 in human airway epithelial cells.

CXCR1 CXCR2

2.55e-06256220016196
Pubmed

Expression of CXC receptor 1 and 2 in esophageal mucosa of patients with reflux esophagitis.

CXCR1 CXCR2

2.55e-06256215793866
Pubmed

Human T lymphocytes and mast cells differentially express and regulate extra- and intracellular CXCR1 and CXCR2.

CXCR1 CXCR2

2.55e-06256215265017
Pubmed

CXCR1 and CXCR2 haplotypes synergistically modulate cystic fibrosis lung disease.

CXCR1 CXCR2

2.55e-06256222088968
Pubmed

Repertaxin, an inhibitor of the chemokine receptors CXCR1 and CXCR2, inhibits malignant behavior of human gastric cancer MKN45 cells in vitro and in vivo and enhances efficacy of 5-fluorouracil.

CXCR1 CXCR2

2.55e-06256226847910
Pubmed

Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease.

ATP1A2 ATP1A3

2.55e-06256224356962
Pubmed

Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8 (CXCL-8)-mediated modulation of metastatic phenotype.

CXCR1 CXCR2

2.55e-06256214713106
Pubmed

C5b-9 glomerular deposition and tubular alpha3beta1-integrin expression are implicated in the development of chronic lesions and predict renal function outcome in immunoglobulin A nephropathy.

C5 ITGA3

2.55e-06256219230171
Pubmed

Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes.

CXCR1 CXCR2

2.55e-06256227551720
Pubmed

[The role of CXCR1/2 in shear stress-induced endothelial cell migration].

CXCR1 CXCR2

2.55e-06256219634663
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

TMTC4 EBP RNF213 NDFIP2 SRPRA ATP13A3 FLRT3 C5 ITGA3 ATP8B2

6.66e-061061561033845483
Pubmed

Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.

ATP1A2 ATP1A3

7.63e-0635622822726
Pubmed

Na+/K+-ATPase α isoform deficiency results in distinct spreading depolarization phenotypes.

ATP1A2 ATP1A3

7.63e-06356230819023
Pubmed

Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2.

CXCR1 CXCR2

7.63e-06356217295203
Pubmed

CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.

CXCR1 CXCR2

7.63e-06356222996693
Pubmed

Interleukin-8 receptors R1 and R2 activate mitogen-activated protein kinases and induce c-fos, independent of Ras and Raf-1 in Chinese hamster ovary cells.

CXCR1 CXCR2

7.63e-0635629843397
Pubmed

CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation.

CXCR1 CXCR2

7.63e-06356221749879
Pubmed

Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.

CXCR1 CXCR2

7.63e-06356211196695
Pubmed

Structure and functional expression of a human interleukin-8 receptor.

CXCR1 CXCR2

7.63e-0635621840701
Pubmed

CXCR1 and CXCR2 activation and regulation. Role of aspartate 199 of the second extracellular loop of CXCR2 in CXCL8-mediated rapid receptor internalization.

CXCR1 CXCR2

7.63e-06356217204468
Pubmed

Molecular evolution of the human interleukin-8 receptor gene cluster.

CXCR1 CXCR2

7.63e-0635621303245
Pubmed

Association of single nucleotide polymorphisms in CXCR1, CXCR2 and CXCL5 with Behçet disease: a study in the Denizli province of Turkey.

CXCR1 CXCR2

7.63e-06356234050991
Pubmed

Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors.

CXCR1 CXCR2

7.63e-06356220630874
Pubmed

Dynamic regulation of CXCR1 and CXCR2 homo- and heterodimers.

CXCR1 CXCR2

7.63e-06356219890050
Pubmed

Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial.

CXCR1 CXCR2

7.63e-06356216679868
Pubmed

The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma.

CXCR1 CXCR2

7.63e-06356222626766
Pubmed

Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B.

CXCR1 CXCR2

7.63e-0635628195702
Pubmed

Differential expression of Na+/K+-ATPase alpha-subunits in mouse hippocampal interneurones and pyramidal cells.

ATP1A2 ATP1A3

7.63e-06356217947306
Pubmed

Neutrophil chemotaxis caused by chronic obstructive pulmonary disease alveolar macrophages: the role of CXCL8 and the receptors CXCR1/CXCR2.

CXCR1 CXCR2

7.63e-06356223912333
Pubmed

Characterization of two high affinity human interleukin-8 receptors.

CXCR1 CXCR2

7.63e-0635621379593
Pubmed

Analysis of the concentration of CXCL8 chemokine and its CXCR1 and CXCR2 receptors in peritoneal fluid of women with endometriosis.

CXCR1 CXCR2

7.63e-06356236086981
Pubmed

IL-8 gene variants are associated with lung function decline and multidimensional BODE index in COPD patients but not with disease susceptibility: a validation study.

CXCR1 CXCR2

7.63e-06356224946112
Pubmed

Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.

ATP1A2 ATP1A3

7.63e-06356219058785
Pubmed

Knockout of sodium pump α3 subunit gene (Atp1a3-/-) results in perinatal seizure and defective respiratory rhythm generation.

ATP1A2 ATP1A3

7.63e-06356228465228
Pubmed

The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases.

CXCR1 CXCR2

7.63e-06356224678812
Pubmed

EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors.

GPR18 GPR183

7.63e-06356221261596
Pubmed

Association between interleukin-8 gene alleles and human susceptibility to tuberculosis disease.

CXCR1 CXCR2

7.63e-06356212870115
Pubmed

Identification of biologically active peptides that inhibit binding of human CXCL8 to its receptors from a random phage-epitope library.

CXCR1 CXCR2

7.63e-06356219118103
Pubmed

Decreased content of ascorbic acid (vitamin C) in the brain of knockout mouse models of Na+,K+-ATPase-related neurologic disorders.

ATP1A2 ATP1A3

7.63e-06356233544780
Pubmed

Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression.

ATP1A2 ATP1A3

7.63e-0635628203495
Pubmed

Interleukin-8 is related to poor chemotherapeutic response and tumourigenicity in hepatocellular carcinoma.

CXCR1 CXCR2

7.63e-06356224161763
Pubmed

Inhibition of interleukin 8/C‑X-C chemokine receptor 1,/2 signaling reduces malignant features in human pancreatic cancer cells.

CXCR1 CXCR2

7.63e-06356229749433
Pubmed

A Preliminary Report of the Relationship Between Gene Polymorphism of IL-8 and Its Receptors and Systemic Inflammatory Response Syndrome Caused by Wasp Stings.

CXCR1 CXCR2

7.63e-06356231613654
Pubmed

Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma.

CXCR1 CXCR2

7.63e-06356215598788
Pubmed

Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny.

CXCR1 CXCR2

7.63e-06356211007922
Pubmed

Na,K-ATPase and the role of alpha isoforms in behavior.

ATP1A2 ATP1A3

7.63e-06356218044013
Pubmed

The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma.

CXCR1 CXCR2

7.63e-06356226267317
Pubmed

[Influence of IFN on expression of chemokine receptor CXCR1, CXCR2 and their ligand IL-8 in the patients with chronic hepatitis B].

CXCR1 CXCR2

7.63e-06356222482416
Pubmed

Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2.

CXCR1 CXCR2

7.63e-06356231666007
Pubmed

CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study.

CXCR1 CXCR2

7.63e-06356220089160
Pubmed

Synergistic interactions between chemokine receptor elements in recognition of interleukin-8 by soluble receptor mimics.

CXCR1 CXCR2

7.63e-06356222242662
Pubmed

Cell migration to the chemokine CXCL8: paxillin is activated and regulates adhesion and cell motility.

CXCR1 CXCR2

7.63e-06356219151925
Pubmed

The CXCL8-CXCR1/2 pathways in cancer.

CXCR1 CXCR2

7.63e-06356227578214
Pubmed

Association of interleukin 8 with myocardial infarction: results from the Stockholm Heart Epidemiology Program.

CXCR1 CXCR2

7.63e-06356224462138
InteractionCXCR2 interactions

ADRA1A EMP1 CXCR1 CXCR2

2.02e-0636514int:CXCR2
InteractionOPALIN interactions

TMTC4 DPY19L1 SLC27A6 RNF213 ATP13A3 ATP1A3

1.41e-05209516int:OPALIN
InteractionGNA14 interactions

GNAT1 CXCR1 CXCR2

1.97e-0521513int:GNA14
InteractionCXCR1 interactions

ADRA1A CXCR1 CXCR2

1.97e-0521513int:CXCR1
InteractionEMP1 interactions

CD37 EBP EMP1 CXCR2

2.20e-0565514int:EMP1
InteractionGNA15 interactions

CXCR1 OPRD1 CXCR2

3.81e-0526513int:GNA15
InteractionARL5B interactions

SYP GNAT1 ATP1A3 GRPR

4.75e-0579514int:ARL5B
InteractionTYROBP interactions

CD47 ATP13A3 ATP1A3 CD200R1

7.25e-0588514int:TYROBP
InteractionF2R interactions

PCSK7 GNAT1 GRPR

9.44e-0535513int:F2R
InteractionADRA1A interactions

ADRA1A CXCR1 CXCR2

1.12e-0437513int:ADRA1A
InteractionKLRD1 interactions

SLC27A6 ATP13A3 ATP1A3 ATP8B2

1.39e-04104514int:KLRD1
InteractionHCST interactions

RNF213 NDFIP2 ATP13A3 ATP1A3 ATP8B2

1.67e-04205515int:HCST
InteractionABCA8 interactions

ABCA6 ABCA8

2.23e-049512int:ABCA8
InteractionCD37 interactions

CD37 EMP1

2.23e-049512int:CD37
InteractionZDHHC9 interactions

GDPD5 NDFIP2 NRSN1

2.59e-0449513int:ZDHHC9
InteractionTPST2 interactions

ATP13A3 NRSN1 ATP1A3 CHRNA3

2.73e-04124514int:TPST2
InteractionABCA6 interactions

ABCA6 ABCA8

2.79e-0410512int:ABCA6
CytobandXp11.23-p11.22

EBP SYP

3.06e-057562Xp11.23-p11.22
Cytoband14q32.33

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

1.78e-0422856414q32.33
CytobandEnsembl 112 genes in cytogenetic band chr13q32

GPR18 TMTC4 GPR183

2.27e-0496563chr13q32
Cytoband13q32.3

TMTC4 GPR183

3.64e-042356213q32.3
Cytoband2q35

CXCR1 CXCR2

4.24e-03795622q35
CytobandEnsembl 112 genes in cytogenetic band chr14q32

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

5.06e-03566564chr14q32
CytobandEnsembl 112 genes in cytogenetic band chr17q24

ABCA6 ABCA8

6.44e-0398562chr17q24
CytobandEnsembl 112 genes in cytogenetic band chr2q35

CXCR1 CXCR2

1.09e-02129562chr2q35
CytobandEnsembl 112 genes in cytogenetic band chr8p21

ADRA1A CHRNA2

1.19e-02135562chr8p21
GeneFamilyCD molecules|C-X-C motif chemokine receptors

CXCR1 CXCR2

8.63e-0564421094
GeneFamilyATPase Na+/K+ transporting subunits

ATP1A2 ATP1A3

1.21e-0474421208
GeneFamilyATP binding cassette subfamily C

ABCC3 ABCC12

4.44e-0413442807
GeneFamilyATP binding cassette subfamily A

ABCA6 ABCA8

5.17e-0414442805
GeneFamilyCholinergic receptors nicotinic subunits

CHRNA2 CHRNA3

6.80e-0416442173
GeneFamilyImmunoglobulin heavy locus at 14q32.33

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

1.09e-03187444349
GeneFamilyADAM metallopeptidase domain containing|CD molecules

CD37 CD47 ITGA3 CXCR1 CXCR2

2.59e-03394445471
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

CXCR1 CXCR2

4.68e-0342442602
GeneFamilyG protein-coupled receptors, Class A orphans

GPR18 GPR183

1.55e-0278442262
CoexpressionAtlasdev lower uro neuro_e14.5_PelvicGanglion_Sox10_k-means-cluster#1_top-relative-expression-ranked_500

SYP NRSN1 CSMD3 CHRNA3

4.22e-0584494gudmap_dev lower uro neuro_e14.5_PelvicGanglion_Sox10_k1_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_500

SLC35F3 CD47 ATP13A3 FLRT3 NRSN1 CSMD3 CHRNA3

5.25e-05427497DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_500
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder detrusor (LCM)_emap-30376_k-means-cluster#4_top-relative-expression-ranked_500

SCN7A CD47 ATP13A3 ATP1A2

5.77e-0591494gudmap_developingLowerUrinaryTract_P2_bladder detrusor (LCM)_500_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder detrusor (LCM)_emap-30376_k-means-cluster#1_top-relative-expression-ranked_200

SCN7A ATP13A3 ATP1A2

7.18e-0535493gudmap_developingLowerUrinaryTract_P2_bladder detrusor (LCM)_200_k1
ToppCellFrontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ABCC3 SLC27A6 CD37 GPR183 CD200R1

9.13e-071405658db98a17a4d4b42dbfc75e9cdaa22275fed4f2f0
ToppCellFrontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia.C1qb.Tmem119-Fos)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ABCC3 SLC27A6 CD37 GPR183 CD200R1

9.13e-0714056522098203361f61b9f0ce9f0f2d1369d8bb1379a8
ToppCellFrontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ABCC3 SLC27A6 CD37 GPR183 CD200R1

9.13e-071405652c04fa782aa076e4be8a2781aa04231180bd69bd
ToppCellFrontal_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia.C1qb.Tmem119-Fos)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ABCC3 SLC27A6 CD37 GPR183 CD200R1

9.13e-07140565a9389a6e55d02d5037868c9ecce48b5e8d7c2902
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ILDR2 ADGRG2 CSMD3 ABCA8 CXCR2

1.24e-06149565c5eedb54ef2e0f131aa6730612c921bc19479632
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ILDR2 ADGRG2 CSMD3 ABCA8 CXCR2

1.24e-06149565a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR18 TRPC4 TAAR2 SYP ATP1A3

1.51e-0615556572a19a9ecfd13f6769c4b447d3ce01a855ec6ec7
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SCN7A TAAR2 CSMD3 GRPR CHRNA3

1.51e-061555653b8def9e8f66511736ea37f259511f7c8b7743af
ToppCell5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC35F3 SYP DNAH6 CHRNA2 OPRD1

1.87e-06162565478cf560ef33c5c324142c76417447d4a571a2c9
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Basophil|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD37 GPR183 ATP1A3 CD200R1 CXCR2

2.59e-061735658ca650542655c27516029e5bace97ff1b9dcc256
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD37 GPR183 ATP1A3 CD200R1 CXCR2

2.59e-061735654282b47b33325472f52a4085986988911a372ed8
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A TRPC4 LHFPL3 SCN7A CHRNA2

2.66e-06174565cc4c7f00a25a7814b52d4599166615daa140cc31
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADRA1A ABCA6 TRPC4 CSMD3 ABCA8

2.66e-06174565f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ILDR2 SYP NRSN1 ATP1A3 CHRNA3

3.14e-061805657d3d5608647b6e684e8e185993d106a38c53e76a
ToppCellsevere-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GDPD5 SCN7A NDFIP2 ATP8B2 CD200R1

3.14e-06180565ac03812b1409435c55d323a7516deeac82bd3509
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TMTC4 DPY19L1 ABCC12 NRSN1 DNAH6

3.40e-061835653ebe334ad570e3525341badb558f369c61daf3d3
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

ADRA1A ABCA6 TRPC4 SCN7A ABCA8

3.78e-0618756592d468dde81125d51daf7abd4703741abe1ab91c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC3 RNF213 ITGA3 EMP1 NRSN1

3.98e-06189565aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC3 RNF213 ITGA3 EMP1 NRSN1

3.98e-061895658977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYP NRSN1 ATP1A3 CHRNA3 OPRD1

4.09e-06190565bdbfaced785db79ff965f332759be258dbf743cf
ToppCellTracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA6 SCN7A ATP1A2 CSMD3 ABCA8

4.41e-06193565549a0b750c860b615aff767ad04c9a9d20f802f0
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYP NRSN1 ATP1A3 CHRNA3 OPRD1

4.41e-061935658851275bcf4ecd6e87a91c8784fc5d76d246ff3b
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

ADRA1A ABCA6 TRPC4 SCN7A ABCA8

4.41e-06193565ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgM_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGHV3-38 IGHV3-16 IGHV3-11 SRPRA IGHV3-64

4.41e-061935657b4b0271e4fbece703876acb053ae236afb7cdba
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell|Adult / Lineage, Cell type, age group and donor

ADRA1A ABCA6 TRPC4 SCN7A ABCA8

4.64e-0619556561c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

ADRA1A ABCA6 TRPC4 SCN7A ABCA8

4.64e-06195565603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYP NRSN1 ATP1A3 CHRNA3 OPRD1

4.64e-06195565b25c534fc6320d4da6437ef1b27e32a5d5256f3e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ABCC3 ABCA6 SCN7A CSMD3 ABCA8

4.87e-061975650034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

ADRA1A ABCA6 TRPC4 SCN7A ABCA8

5.00e-0619856526e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADRA1A ABCA6 TRPC4 SCN7A ABCA8

5.25e-06200565e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADRA1A ABCA6 TRPC4 SCN7A ABCA8

5.25e-06200565cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADRA1A ABCA6 TRPC4 SCN7A ABCA8

5.25e-06200565311fab076f2ceb258e3970eb21e39344b894042a
ToppCellMS-IIF-Lymphocyte-T/NK-dn_T|IIF / Disease, condition lineage and cell class

IGHV3-11 TMTC4 EBP GPR183 TP53BP1

5.25e-06200565c34fff02992cba6bcc2308019cb00b94e1227300
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADRA1A ABCA6 ABCC12 ABCA8

1.86e-05125564b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCellBronchial_Biopsy-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

ABCA6 SCN7A EMP1 ABCA8

2.11e-0512956413cd10ffdd8f1ef7721884e9efd2cf25f170f414
ToppCelldroplet-Skin-nan-18m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC3 GRPR CXCR1 CXCR2

2.18e-051305644c8b931987432e8bcd39029d4fa124dc383ea355
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-7|TCGA-Stomach / Sample_Type by Project: Shred V9

TRPC4 ATP1A2 GRPR CHRNA3

2.52e-05135564451e90c154e26ae4f72269d6765e7ef51d67313a
ToppCell10x5'-blood-Lymphocytic_B_plasma-Plasma_cells|blood / Manually curated celltypes from each tissue

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

3.52e-0514756458089378fac1743ce99dc4f1bd7b5253a927f050
ToppCell10x5'-blood-Lymphocytic_B_plasma|blood / Manually curated celltypes from each tissue

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

3.81e-051505646bab0a8bf78ed7de9e1b67ede7496488f80f4863
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A ADGRG2 TRPC4 FLRT3

4.01e-051525648ff5a178a8f3550d89a003c0858820aab3773386
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ADRA1A SCN7A GRPR CHRNA3

4.33e-05155564105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCellStriatum-Hematopoietic|Striatum / BrainAtlas - Mouse McCarroll V32

ABCC3 CD37 GPR183 CD200R1

4.33e-0515556412301d823338bf829475905c66c5f08f7159d29f
ToppCellGlobus_pallidus-Hematopoietic|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ABCC3 CD37 GPR183 CD200R1

4.44e-0515656467cdaadc3b917f7072adce16c0391472c14a2563
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC3 CD37 GPR183 CD200R1

4.55e-051575647fdc0094dd5729990a91a30c1982a14c74650b52
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC3 CD37 GPR183 CD200R1

4.55e-05157564c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC3 CD37 GPR183 CD200R1

4.55e-051575646b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Lymphocytic-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR18 CD37 TAAR2 GPR183

4.66e-0515856498fd640ef0bd0014b8c38b81bd5160efcf42f23c
ToppCelldroplet-Heart-nan-18m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD37 ATP1A3 CXCR1 CXCR2

4.66e-0515856481a5a73090804d41429d297ba2462a842f39d380
ToppCelldroplet-Heart-nan-18m-Myeloid-cardiac_mast_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD37 ATP1A3 CXCR1 CXCR2

4.66e-051585649596b7b0f6f5157a43d67d2e67fb75a2624a6bb9
ToppCelldroplet-Heart-nan-18m-Myeloid-mast_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD37 ATP1A3 CXCR1 CXCR2

4.66e-051585647ebc8b778c97c0faa79e2d80c98b887fa635f901
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Lymphocytic|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR18 CD37 TAAR2 GPR183

4.66e-051585644d2d69fbb880b5232d7867b4d099d0f047ca9ebe
ToppCellFrontal_cortex-Hematopoietic-MICROGLIA|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ABCC3 CD37 GPR183 CD200R1

4.78e-0515956441d2c1e71f6983156f8cc8ec5f69e025e5700f46
ToppCellFrontal_cortex-Hematopoietic|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ABCC3 CD37 GPR183 CD200R1

4.90e-0516056470ffbe61cfd729519b23569a43d929b117ab8d5e
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SCN7A CSMD3 GRPR CHRNA3

5.02e-051615643b5d7a3dab479c6959a428f3954dedd989900276
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYP NRSN1 ATP1A3 CHRNA3

5.02e-0516156469f5e759c0925daa37e0177a9cc3154842906bf6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA6 ADGRG2 ATP1A2 ABCA8

5.02e-05161564a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYP NRSN1 ATP1A3 CHRNA3

5.52e-051655646d8b5669eee9b0903c9260fea707d186c9d7fefa
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYP NRSN1 ATP1A3 CHRNA3

5.52e-0516556402cd87dfa2ca40e13455a4b9308477e82f76289b
ToppCellThalamus-Hematopoietic|Thalamus / BrainAtlas - Mouse McCarroll V32

ABCC3 CD37 GPR183 CD200R1

5.65e-0516656476d60ac7ac5d1eaf530f0c741d9c48e0bd58396b
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgM_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

5.65e-051665642b7b580bec8d9467b0deaf97098065f72dbf2a4f
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SCN7A CSMD3 GRPR CHRNA3

5.92e-05168564f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCellBronchial_Brush-Immune-B_cells|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

GPR18 IGHV3-11 CD37 GPR183

6.06e-05169564dc388f660f69e37e517bf3243daf071ab138ee6e
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

SCN7A ATP1A2 NRSN1 ABCA8

6.06e-0516956441cb92b0558f0d5a3e511058efd9110258b88ee3
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

SCN7A ATP1A2 NRSN1 ABCA8

6.06e-0516956491f4b6a14708e701b2af22989004282041777491
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

ABCA6 SCN7A EMP1 ABCA8

6.06e-051695646373562ab3b1765060212a6a53d6543e7e942e80
ToppCellTCGA-Brain|World / Sample_Type by Project: Shred V9

LHFPL3 NTSR2 ATP1A2 NRSN1

6.20e-05170564f78e360a6a44d599ec0d207cba4704e50aa314f8
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A LHFPL3 SCN7A CHRNA2

6.20e-05170564667443062882642211ad116043775ef8eda38859
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPR18 IGHV3-11 CD37 IGHV3-64

6.49e-05172564172e3c78f8e97988a4fd8624514e731282ddc16d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TMTC4 DPY19L1 ABCC12 DNAH6

6.49e-0517256492e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPR18 IGHV3-11 CD37 IGHV3-64

6.49e-051725645fb0ea6145892a258696197b3feed9760187e712
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPR18 IGHV3-11 CD37 IGHV3-64

6.49e-051725642214cc37d7c21b868768d3f74ca4631d339d37b3
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPR18 IGHV3-11 CD37 IGHV3-64

6.49e-0517256407620728a6cdeea805e1365e588be096c17a370c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TMTC4 DPY19L1 ABCC12 DNAH6

6.63e-05173564ee972d9cc68755926512fd3bbe1267098c67cd94
ToppCelldroplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LHFPL3 GPR183 CD200R1 CXCR2

6.63e-05173564120dd20e8a71f9169a1596b6171df7aa0b96dd15
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1-3_PAX6_NABP1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A TRPC4 LHFPL3 SCN7A

6.63e-051735640d38206e25434386b1aec2078067efc67b496c10
ToppCelldroplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LHFPL3 GPR183 CD200R1 CXCR2

6.63e-05173564b2c55084ef6dac0e329c2e65c24cfe0045859c30
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Basophil|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD37 GPR183 ATP1A3 CXCR2

6.63e-051735642cba41c3d9d3076f703115d19729073a3ac3feb6
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD37 GPR183 ATP1A3 CXCR2

6.63e-0517356411d69a4ab4a87b8820cd3bd204de8c4124450a90
ToppCell5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCN7A FLRT3 ATP1A2 ABCA8

6.78e-05174564c9d4e375dedd2b099a9ed70ec38ff35bbb0ce48a
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3|TCGA-Breast / Sample_Type by Project: Shred V9

ADRA1A ABCA6 ATP1A2 ABCA8

6.78e-051745647f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCellTCGA-Breast-Solid_Tissue_Normal|TCGA-Breast / Sample_Type by Project: Shred V9

ADRA1A ABCA6 ATP1A2 ABCA8

6.78e-05174564e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCell5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCN7A FLRT3 ATP1A2 ABCA8

6.78e-051745641463c98f8f519dd030587abbdbeb1b4e1bca5dd1
ToppCell5'-GW_trimst-2-LymphNode-Neuronal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCN7A FLRT3 ATP1A2 ABCA8

6.78e-05174564d421c0069d24cb560a3a429929e3cd1eceaeabcf
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SCN7A CSMD3 GRPR CHRNA3

6.78e-05174564a5f2a4e3b25e6084bd7003a53da86a44f6fcf294
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

ADRA1A ABCA6 ATP1A2 ABCA8

6.78e-051745640f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

ADRA1A ABCA6 ATP1A2 ABCA8

6.78e-051745641aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCellfacs-BAT|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR18 CD37 GPR183 CXCR2

6.94e-0517556446d6e319f8ca46592f23257800bcb6d228fffbbe
ToppCell10x3'2.3-week_17-19-Neuro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SCN7A FLRT3 ATP1A2 ABCA8

6.94e-05175564bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A TMTC4 ATP1A3 CHRNA2

6.94e-051755649d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCell10x3'2.3-week_17-19-Neuro-stroma-schwann_cells|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SCN7A FLRT3 ATP1A2 ABCA8

6.94e-051755648b010220cdfb680ec839572f4933adfb85045ea6
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR18 CD37 GPR183 CSMD3

6.94e-05175564887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell10x3'2.3-week_17-19-Neuro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SCN7A FLRT3 ATP1A2 ABCA8

6.94e-051755640b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ABCA6 SCN7A EMP1 ABCA8

7.09e-051765642e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCelldroplet-Bladder-nan-24m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR18 CD37 GPR183 CD200R1

7.09e-051765640089b50d607f4d2f18639fab0f3fc779227baa7a
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

ABCA6 SCN7A EMP1 ABCA8

7.09e-05176564f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGHV3-38 IGHV3-16 IGHV3-11 IGHV3-64

7.25e-051775644c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA6 SLC27A6 ATP1A2 ABCA8

7.25e-051775649ec7f1e64312d26d434b3312b58386715dbad644
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A LHFPL3 SCN7A CHRNA2

7.25e-05177564fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ILDR2 SLC27A6 NDFIP2 FLRT3

7.25e-051775648c6d8a1c469346e66f9095d86b4615f8fc611362
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA6 SLC27A6 ATP1A2 ABCA8

7.25e-05177564016277dfd59b1793fddaaadc2b3f41622d76ce3a
ComputationalGenes in the cancer module 288.

GRPR OPRD1 CXCR2

2.48e-0437363MODULE_288
ComputationalGenes in the cancer module 412.

CD47 ITGA3

8.31e-0413362MODULE_412
ComputationalAcetylCholine receptors.

CHRNA2 CHRNA3

9.68e-0414362MODULE_328
ComputationalGenes in the cancer module 27.

GPR183 ITGA3 GRPR CHRNA2 CHRNA3 CXCR2

1.05e-03355366MODULE_27
ComputationalGenes in the cancer module 267.

CHRNA2 CHRNA3

1.11e-0315362MODULE_267
ComputationalGenes in the cancer module 275.

CD47 ITGA3

1.27e-0316362MODULE_275
ComputationalMembranal receptors.

CD37 SCN7A NTSR2 GPR183 ITGA3 GRPR CHRNA2

1.41e-03517367MODULE_64
Drugverapamil

ABCC3 ADRA1A ABCA6 SCN7A PCSK7 ABCC12 ATP1A2 ATP1A3 CHRNA2 ABCA8 CHRNA3

1.12e-084905211CID000002520
Drugtetradotoxin

ADRA1A HTR1D SCN7A NTSR2 SYP ATP1A2 ATP1A3 CHRNA2 CHRNA3 OPRD1

3.88e-084285210CID000020382
Drugdeltorphin II, Ala(2)-

CXCR1 OPRD1 CXCR2

4.49e-084523ctd:C060209
Drugneostigmine

ADRA1A HTR1D ATP1A2 ATP1A3 CHRNA2 CHRNA3

4.62e-0887526CID000004456
Drugmyo-inositol

ADRA1A GPR18 TRPC4 NTSR2 PCSK7 FLRT3 GPR183 GNAT1 GRPR CHRNA2 CHRNA3 OPRD1

2.14e-078115212CID000000892
Drugphentolamine

ADRA1A HTR1D ATP1A2 ATP1A3 CHRNA2 CHRNA3 OPRD1

3.48e-07200527CID000005775
Drug(+/-)-Epibatidine

HTR1D SYP CHRNA2 CHRNA3

1.20e-0635524CID000001204
Drugacetylcholine

ADRA1A HTR1D SYP ATP1A2 ATP1A3 CHRNA2 CHRNA3 OPRD1

1.51e-06361528CID000000187
DrugNSC7524

HTR1D SCN7A ATP1A2 ATP1A3 CHRNA2 CHRNA3

3.60e-06182526CID000005657
Drug3-isoreserpine

ABCC3 ADRA1A HTR1D ABCA6 ABCC12 ABCA8

4.62e-06190526CID000005052
Drugphenoxybenzamine

ADRA1A HTR1D CHRNA2 CHRNA3 OPRD1

6.48e-06115525CID000004768
DrugSubstance P

HTR1D NTSR2 SYP GRPR CHRNA2 CHRNA3 OPRD1

1.24e-05343527CID000036511
DrugUltracet

HTR1D CHRNA2 CHRNA3 OPRD1

1.39e-0564524CID000005523
Drug4-DAMP

HTR1D TRPC4 CHRNA2 CHRNA3

1.48e-0565524CID000001734
Drugdiaminocyclobut-3-ene-1,2-dione

CXCR1 CXCR2

1.53e-053522CID002781329
Drug5-methoxysalicylaldehyde

CXCR1 CXCR2

1.53e-053522CID000095695
DrugDTTA

CXCR1 CXCR2

1.53e-053522CID000166909
DrugIonophores

CXCR1 CXCR2

1.53e-053522ctd:D007476
Drugdimethylcyclohexane

CXCR1 CXCR2

1.53e-053522CID000011549
Drugbenzilate

ADRA1A CHRNA2 CHRNA3 OPRD1

1.57e-0566524CID000201538
DrugAC1NSKJI

ADRA1A HTR1D CHRNA2 CHRNA3

1.77e-0568524CID005311391
Drughexamethonium

ADRA1A HTR1D CHRNA2 CHRNA3 OPRD1

1.87e-05143525CID000003604
DrugCID6325740

HTR1D CHRNA2 CHRNA3

1.93e-0523523CID006325740
DrugDigocin

ABCC3 ATP1A2 ATP1A3 ABCA8

1.98e-0570524CID000003062
DrugBarium

ADRA1A TRPC4 CHRNA2 OPRD1

2.22e-0572524ctd:D001464
Drugoriens

ADRA1A HTR1D SYP CHRNA2 CHRNA3

2.67e-05154525CID000161645
Drugendomorphin 2

CXCR1 OPRD1

3.06e-054522ctd:C105294
Drugnitroethylene

CXCR1 CXCR2

3.06e-054522CID000077197
DrugAS701

ATP1A2 ATP1A3

3.06e-054522CID000133528
Drugmethylcarbamylcholine

HTR1D CHRNA2 CHRNA3

3.16e-0527523CID000004136
Drugoxymetazoline

ADRA1A HTR1D CHRNA2 CHRNA3

3.20e-0579524CID000004636
Drugserotonin

ADRA1A HTR1D SYP ATP1A2 ATP1A3 CHRNA2 CHRNA3 OPRD1

3.43e-05554528CID000005202
Drugbupropion

ADRA1A SCN7A CHRNA2 CHRNA3

3.53e-0581524CID000000444
Drugtrimethaphan

ATP1A2 ATP1A3 CHRNA2 CHRNA3

3.53e-0581524CID000023576
Drugclozapine

ADRA1A HTR1D NTSR2 CHRNA2 CHRNA3 OPRD1

3.68e-05274526CID000002818
DrugNSC755875

ADRA1A HTR1D CHRNA2 CHRNA3 OPRD1

3.71e-05165525CID000002215
DrugEN-1530

ADRA1A EBP NTSR2 CHRNA2 CHRNA3 OPRD1

3.99e-05278526CID000004425
Drugpseudococaine

ADRA1A HTR1D SCN7A CHRNA2 CHRNA3 CXCR1 OPRD1 CXCR2

4.19e-05570528CID000002826
Drugbrimonidine

ADRA1A HTR1D CHRNA2 CHRNA3

4.47e-0586524CID000002435
DrugGR 127935

ADRA1A HTR1D

5.09e-055522ctd:C090701
Drug22,23-dihydrobufalin

ATP1A2 ATP1A3

5.09e-055522CID000195392
Drug3-acetylstrophanthin

ATP1A2 ATP1A3

5.09e-055522CID003082282
Drugthevetin A

ATP1A2 ATP1A3

5.09e-055522CID000441873
Drugmecamylamine

HTR1D CHRNA2 CHRNA3 OPRD1

5.12e-0589524CID000004032
Drugtropicamide

HTR1D CHRNA2 CHRNA3

5.32e-0532523CID000005593
DrugNorcyclobenzaprine [303-50-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A

GDPD5 TRPC4 GNAT1 EMP1 CHRNA3

5.62e-051805254776_UP
DrugDichloroacetic Acid

ABCC3 ADRA1A ABCC12 C5 GNAT1 ATP1A2 GRPR CHRNA2 CXCR1 CXCR2

5.68e-059675210ctd:D003999
Drugamsonine

ADRA1A HTR1D CHRNA2 CHRNA3 OPRD1

5.77e-05181525CID000002866
Drugcytisine

HTR1D CHRNA2 CHRNA3

5.84e-0533523CID000010235
DrugMonensin sodium salt [22373-78-0]; Up 200; 5.8uM; HL60; HT_HG-U133A

EMP1 ATP1A2 ATP1A3 ABCA8 CHRNA3

7.63e-051925252580_UP
Drugdecamethonium

CHRNA2 CHRNA3

7.63e-056522ctd:C033019
Drugoleandrin

CXCR1 CXCR2

7.63e-056522ctd:C021065
DrugM 129

CXCR1 CXCR2

7.63e-056522CID000192788
Drug2-methoxy-6-methylaminopyridine

CXCR1 CXCR2

7.63e-056522CID007019167
Drugantileukinate

CXCR1 CXCR2

7.63e-056522ctd:C118980
DrugNeurotensin (1-6)

HTR1D NTSR2

7.63e-056522CID000137323
DrugETH157

ATP1A2 ATP1A3

7.63e-056522CID000563154
DrugFenbufen [36330-85-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A

ABCC3 ADRA1A GPR183 ATP1A2 GRPR

7.82e-051935254743_UP
DrugDomperidone maleate; Up 200; 7.4uM; MCF7; HT_HG-U133A

ADRA1A GNAT1 EMP1 GRPR CHRNA3

8.01e-051945255701_UP
DrugGi-2

ADRA1A GNAT1 CXCR1 OPRD1 CXCR2

8.21e-05195525CID011957432
DrugHHSiD

HTR1D CHRNA2 CHRNA3

8.26e-0537523CID000003602
DrugICI 182,780; Up 200; 0.01uM; HL60; HT_HG-U133A

ADRA1A CD37 GNAT1 ATP1A2 CHRNA3

8.61e-051975252698_UP
Drugcholine

HTR1D PCSK7 ATP1A2 ATP1A3 CHRNA2 CHRNA3

8.69e-05320526CID000000305
DrugNicardipine hydrochloride [54527-84-3]; Up 200; 7.8uM; MCF7; HT_HG-U133A

GPR183 EMP1 ATP1A3 ATP8B2 CXCR2

8.82e-051985253215_UP
Drugcobalt(II) chloride hexahydrate; Down 200; 100uM; MCF7; HG-U133A

ADRA1A TAAR2 EMP1 GRPR CHRNA3

8.82e-05198525383_DN
Drugepicholesterol

HTR1D ABCA6 EBP PCSK7 SYP CHRNA2 ABCA8 CHRNA3

9.02e-05636528CID000000304
Drugcyclosarin

ABCC3 ADRA1A EMP1 CXCR1 CXCR2

9.03e-05199525CID000064505
DrugZalcitabine [7481-89-2]; Up 200; 19uM; PC3; HT_HG-U133A

ADRA1A MC3R GNAT1 CHRNA3 CXCR2

9.03e-051995254215_UP
DrugCytochalasin D

GNAT1 CXCR1 CXCR2

9.69e-0539523ctd:D015638
Drugmethylatropine

ADRA1A CHRNA2 CHRNA3

1.05e-0440523CID000005860
Drugtridigitoxoside

ATP1A3 ABCA8 CXCR2

1.05e-0440523CID000003061
Drugdihydropyrone

ATP1A2 ATP1A3

1.07e-047522CID000010760
DrugN-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine

ATP1A2 ATP1A3

1.07e-047522ctd:C481648
Drugdihydrodigitoxigenin

ATP1A2 ATP1A3

1.07e-047522CID000107549
Drug2-(4-isobutylphenyl)propionylmethanesulfonamide

CXCR1 CXCR2

1.07e-047522ctd:C490707
DrugQX-222

PCSK7 CHRNA2 CHRNA3

1.21e-0442523CID000005014
Druggallamin

HTR1D CHRNA2 CHRNA3

1.30e-0443523CID000067425
Drugatropine sulfate

ADRA1A HTR1D GRPR CHRNA2 CHRNA3 OPRD1

1.35e-04347526CID000003661
Drugdihydro-beta-erythroidine

HTR1D CHRNA2 CHRNA3

1.39e-0444523CID000031762
DrugDimethylphenylpiperazinium Iodide

CHRNA2 CHRNA3

1.42e-048522ctd:D004246
Drugglutaconyl-CoA

ATP1A2 ATP1A3

1.42e-048522CID009543049
Drugepibatidine

CHRNA2 CHRNA3

1.42e-048522ctd:C082748
Drugflerobuterol

ADRA1A HTR1D

1.42e-048522CID000071254
DrugAlstonine hydrochloride

GDPD5 GNAT1 CXCR1 CXCR2

1.43e-04116524CID000023039
DrugNSC186061

ADRA1A HTR1D NTSR2 OPRD1

1.53e-04118524CID000004163
Drugpentobarbital

ADRA1A SCN7A CHRNA2 CHRNA3 OPRD1

1.57e-04224525CID000004737
Drugipratropium bromide

HTR1D CHRNA2 CHRNA3

1.59e-0446523CID000003746
Drugpilsicainide

SCN7A CHRNA2 CHRNA3

1.59e-0446523CID000004820
Drugphenidone

C5 ATP1A2 ATP1A3

1.59e-0446523CID000007090
DrugDigoxin

ATP1A2 ATP1A3 ABCA8

1.59e-0446523ctd:D004077
Drugfluoxetine

ADRA1A HTR1D SYP CHRNA2 CHRNA3

1.61e-04225525CID000003386
Drugmelantonin

HTR1D OPRD1

1.82e-049522CID000077899
DrugBRL 41992

ADRA1A HTR1D

1.82e-049522CID000124249
Drugiodide

CD47 NTSR2 GRPR CHRNA2 CHRNA3 CXCR1 CXCR2

2.01e-04534527CID000024841
Drugdopamine

ADRA1A HTR1D NTSR2 SYP ATP1A3 CHRNA2 CHRNA3 OPRD1

2.02e-04715528CID000000681
DrugMcN-A-343

HTR1D CHRNA2 CHRNA3

2.04e-0450523CID000004022
Drugchlorisondamine

ADRA1A CHRNA2 CHRNA3

2.17e-0451523CID000006243
Drugtyramine

ADRA1A HTR1D TAAR2 ATP1A2

2.22e-04130524CID000005610
DrugCM 29-712

ADRA1A HTR1D

2.28e-0410522CID000159842
DrugPT430

ABCC3 EMP1

2.28e-0410522CID003035882
DiseaseALTERNATING HEMIPLEGIA OF CHILDHOOD 1

ATP1A2 ATP1A3

3.17e-062532C3549447
Diseasealternating hemiplegia of childhood (is_implicated_in)

ATP1A2 ATP1A3

3.17e-062532DOID:0050635 (is_implicated_in)
DiseaseAlternating hemiplegia of childhood

ATP1A2 ATP1A3

1.89e-054532C0338488
Diseasealcohol use disorder (implicated_via_orthology)

ADRA1A ATP1A2 ATP1A3 CHRNA2 CHRNA3

2.66e-05195535DOID:1574 (implicated_via_orthology)
Diseasefamilial hemiplegic migraine (implicated_via_orthology)

ATP1A2 ATP1A3

6.61e-057532DOID:0060178 (implicated_via_orthology)
Diseaseapolipoprotein B to apolipoprotein A1 ratio

ABCA6 PCSK7 ABCA8

9.51e-0549533EFO_0021897
Diseasecholesterol to total lipids in medium HDL percentage

PCSK7 ABCA8 TP53BP1

1.74e-0460533EFO_0022237
Diseasenervous system disease (implicated_via_orthology)

ATP1A2 ATP1A3

2.07e-0412532DOID:863 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SCN7A ITGA3 ATP1A2 ATP1A3

2.13e-04163534DOID:1826 (implicated_via_orthology)
Diseasephosphatidylcholine 38:6 measurement

ABCC3 TMTC4

3.74e-0416532EFO_0010388
Diseasecongenital myasthenic syndrome (implicated_via_orthology)

CHRNA2 CHRNA3

3.74e-0416532DOID:3635 (implicated_via_orthology)
DiseaseX-24309 measurement

ADRA1A CHRNA2

5.89e-0420532EFO_0800872
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

ABCA6 PCSK7 ABCA8 TP53BP1

6.61e-04220534EFO_0004529, EFO_0008317
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

ABCA6 PCSK7 ABCA8 TP53BP1

7.19e-04225534EFO_0008317, EFO_0010351
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

ABCA6 PCSK7 ABCA8 TP53BP1

7.19e-04225534EFO_0008317, EFO_0020947
Diseasephospholipids:total lipids ratio

ABCA6 PCSK7 ABCA8 TP53BP1

7.43e-04227534EFO_0020946
Diseasevery low density lipoprotein cholesterol measurement, phospholipid measurement

ABCA6 PCSK7 ABCA8 TP53BP1

7.68e-04229534EFO_0004639, EFO_0008317
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

ABCA6 PCSK7 ABCA8 TP53BP1

9.00e-04239534EFO_0008317, EFO_0020945
Diseaseapolipoprotein A 1 measurement, apolipoprotein B measurement

ABCA6 PCSK7 ABCA8

9.52e-04107533EFO_0004614, EFO_0004615
Diseasecholesteryl ester measurement

ABCA6 PCSK7 ABCA8 TP53BP1

1.18e-03257534EFO_0010351
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

ABCA6 PCSK7 ABCA8 TP53BP1

1.30e-03264534EFO_0008317, EFO_0020944
Diseasetriglycerides:total lipids ratio, intermediate density lipoprotein measurement

ABCA6 PCSK7 TP53BP1

1.56e-03127533EFO_0008595, EFO_0020947
DiseaseBipolar Disorder

ADRA1A CD47 ATP1A2 ATP1A3 CHRNA2

1.64e-03477535C0005586

Protein segments in the cluster

PeptideGeneStartEntry
GKFLCVKLVVFVSFW

TMEM184C

246

Q9NVA4
FWNLVFLLTVSCVKG

CSMD3

46

Q7Z407
WVFTLVCILGTAGLF

CHRNA3

481

P32297
ICIGFQSLGFFWVKQ

ATP13A3

1016

Q9H7F0
AKTLGIVVGCFVLCW

ADRA1A

271

P35348
CIFIIGLFVNITALW

GPR18

31

Q14330
WSIFLIGTKIGLFLQ

FLRT3

6

Q9NZU0
VVFLLTLFWGCLGFT

ABCA6

331

Q8N139
IRKYILKFCIVGWGV

ADGRG2

731

Q8IZP9
WLFIIVCFLGTIGLF

CHRNA2

506

Q15822
VLWIFGFLVCMGVIL

ATP8B2

296

P98198
VQSSGVLIIFWFLCV

ABCC3

131

O15438
LGWICFCFSFIIGVL

EMP1

136

P54849
VCVRLVGTAWFFGLI

OR10AD1

141

Q8NGE0
SWVFLVAIIKGVQCQ

IGHV3-11

6

P01762
LSWVFLVAIFKGVQC

IGHV3-64

6

A0A075B6Q5
GLLSFIVWKKTFIQG

NTSR2

261

O95665
KWIHCFEGVTCIIFI

GNAT1

206

P11488
SWVFLVGILKGVQCE

IGHV3-38

6

A0A0C4DH36
KTLVLVGCFTVFWTV

PCSK7

666

Q16549
LGLIILLLWKCGFFK

ITGA3

1006

P26006
GIQTGLTWVALIFCI

OR51I1

21

Q9H343
GWIFGTFLCKVVSLL

CXCR2

111

P25025
FWKVGLISGTVFVIL

NRSN1

61

Q8IZ57
VIQGCFWLFGTVILK

DPY19L1

341

Q2PZI1
TIVGFIWLLKVNGCR

CD200R1

256

Q8TD46
VSFTLIVGIFVLQKW

GDPD5

506

Q8WTR4
KLINICIWVLASGVG

OPRD1

166

P41143
CGFGLSLIKWILIVR

NDFIP2

266

Q9NV92
EWVKFCRQLFGGFSI

ATP1A2

86

P50993
LGKKWRQIIFGICFF

DNAH6

3681

Q9C0G6
ILCFLIFLGKTWGQE

C5

6

P01031
WLFGRIGCKLIPFIQ

GRPR

106

P30550
NGWIFGTFLCKVVSL

CXCR1

101

P25024
KILGIILGAFIICWL

HTR1D

301

P28221
AVTITILLGVFIFCW

MC3R

241

P41968
KFCRQLFGGFSILLW

ATP1A3

81

P13637
FAILLFWGQFGIKTL

CD47

151

Q08722
VCGFIHLVIEGWFVL

EBP

71

Q15125
SWVFLAGILKGVQCE

IGHV3-16

6

A0A0C4DH30
GSLIFCFGIWILIDK

CD37

26

P11049
LGFVKVLQWVFAIFA

SYP

26

P08247
EHAKGVCIFVWILVF

GPR183

146

P32249
SGKVWVGIGLCIALF

ABCC12

156

Q96J65
AQLKKIFWGVAVVLC

SLC35F3

61

Q8IY50
GLVVFLLTVFWGCLG

ABCA8

331

O94911
SVQTGIWVFLFKLLI

RNF213

2061

Q63HN8
WAKLVVGSVAIVCFA

TMTC4

21

Q5T4D3
VSWIIFLKIGAGCQV

nan

41

Q8N2B8
GVFLFFVLVGICWCQ

ILDR2

196

Q71H61
TIFSKGGLVLWCFQG

SRPRA

6

P08240
AKTLGIVIGVFLLCW

TAAR2

261

Q9P1P5
WVIQCLIVGERIGFK

TP53BP1

1946

Q12888
VENNWFKCFIGLVTL

SCN7A

931

Q01118
VWFGLAKLGCVVAFL

SLC27A6

121

Q9Y2P4
WAVKMVTCFIIGLLF

TRPC4

326

Q9UBN4
IGVLWAIFTICFAIV

LHFPL3

36

Q86UP9