Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tyrosine kinase binding	FRS2 NOX4 FCRL5 TOB1	1.62e-04	149	37	4	GO:1990782
GeneOntologyMolecularFunction	clathrin binding	EPN3 CLINT1 EPN2	2.15e-04	63	37	3	GO:0030276
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	BEST3 BEST4	6.22e-04	20	37	2	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	BEST3 BEST4	6.22e-04	20	37	2	GO:0005229
GeneOntologyCellularComponent	clathrin vesicle coat	EPN3 CLINT1 EPN2	4.13e-05	38	37	3	GO:0030125
GeneOntologyCellularComponent	clathrin coat	EPN3 CLINT1 EPN2	1.33e-04	56	37	3	GO:0030118
GeneOntologyCellularComponent	vesicle coat	EPN3 CLINT1 EPN2	2.26e-04	67	37	3	GO:0030120
GeneOntologyCellularComponent	clathrin-coated vesicle	EPN3 CLINT1 SNX9 EPN2	7.93e-04	237	37	4	GO:0030136
GeneOntologyCellularComponent	membrane coat	EPN3 CLINT1 EPN2	8.69e-04	106	37	3	GO:0030117
GeneOntologyCellularComponent	coated membrane	EPN3 CLINT1 EPN2	8.69e-04	106	37	3	GO:0048475
Domain	ENTH	EPN3 CLINT1 EPN2	1.43e-07	6	37	3	PF01417
Domain	ENTH	EPN3 CLINT1 EPN2	5.96e-07	9	37	3	PS50942
Domain	ENTH	EPN3 CLINT1 EPN2	5.96e-07	9	37	3	SM00273
Domain	ENTH	EPN3 CLINT1 EPN2	8.51e-07	10	37	3	IPR013809
Domain	Tob1/2	TOB2 TOB1	3.82e-06	2	37	2	IPR015676
Domain	-	EPN3 CLINT1 EPN2	1.80e-05	26	37	3	1.25.40.90
Domain	Bestrophin/UPF0187	BEST3 BEST4	2.29e-05	4	37	2	IPR021134
Domain	Bestrophin	BEST3 BEST4	2.29e-05	4	37	2	IPR000615
Domain	Bestrophin	BEST3 BEST4	2.29e-05	4	37	2	PF01062
Domain	ENTH_VHS	EPN3 CLINT1 EPN2	2.52e-05	29	37	3	IPR008942
Domain	Anti_prolifrtn	TOB2 TOB1	5.70e-05	6	37	2	IPR002087
Domain	BTG_2	TOB2 TOB1	5.70e-05	6	37	2	PS01203
Domain	btg1	TOB2 TOB1	5.70e-05	6	37	2	SM00099
Domain	BTG	TOB2 TOB1	5.70e-05	6	37	2	PF07742
Domain	BTG_1	TOB2 TOB1	5.70e-05	6	37	2	PS00960
Domain	UIM	EPN3 EPN2	5.73e-04	18	37	2	PF02809
Domain	UIM	EPN3 EPN2	7.83e-04	21	37	2	SM00726
Domain	UIM	EPN3 EPN2	1.03e-03	24	37	2	PS50330
Domain	UIM_dom	EPN3 EPN2	1.11e-03	25	37	2	IPR003903
Domain	P-loop_NTPase	ASPM WSCD1 DHX32 PSTK ABCA2 DNAH6 DRG1	1.21e-03	848	37	7	IPR027417
Domain	-	WSCD1 DHX32 PSTK ABCA2 DNAH6 DRG1	3.21e-03	746	37	6	3.40.50.300
Domain	-	ZCCHC14 SNX9	4.58e-03	51	37	2	3.30.1520.10
Domain	Phox	ZCCHC14 SNX9	4.76e-03	52	37	2	IPR001683
Pubmed	BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation.	TOB2 TOB1	3.30e-06	3	37	2	25951976
Pubmed	A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob.	TOB2 TOB1	3.30e-06	3	37	2	11260258
Pubmed	Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.	TOB2 TOB1	3.30e-06	3	37	2	22252318
Pubmed	Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family.	BEST3 BEST4	6.60e-06	4	37	2	12032738
Pubmed	Bestrophin expression and function in the human pancreatic duct cell line, CFPAC-1.	BEST3 BEST4	6.60e-06	4	37	2	19237432
Pubmed	Structure-function analysis of the bestrophin family of anion channels.	BEST3 BEST4	6.60e-06	4	37	2	12907679
Pubmed	The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion.	EPN3 EPN2	6.60e-06	4	37	2	20709745
Pubmed	Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.	TOB2 TOB1	6.60e-06	4	37	2	12135500
Pubmed	Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease).	BEST3 BEST4	6.60e-06	4	37	2	9700209
Pubmed	Apoptosis during embryonic tissue remodeling is accompanied by cell senescence.	TOB2 TOB1	1.10e-05	5	37	2	26568417
Pubmed	Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.	EPN3 EPN2	1.65e-05	6	37	2	25122462
Pubmed	TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells.	TOB2 TOB1	1.65e-05	6	37	2	38165569
Pubmed	In search of a function for the TIS21/PC3/BTG1/TOB family.	TOB2 TOB1	1.65e-05	6	37	2	11377414
Pubmed	Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.	TOB2 TOB1	2.30e-05	7	37	2	10602502
Pubmed	Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.	TOB2 TOB1	2.30e-05	7	37	2	11429045
Pubmed	Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing.	TOB2 TOB1	3.95e-05	9	37	2	21726813
Pubmed	Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.	TOB2 TOB1	3.95e-05	9	37	2	17785442
Pubmed	Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1).	IPO7 LMO1	4.93e-05	10	37	2	11528126
Pubmed	Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.	TOB2 TOB1	4.93e-05	10	37	2	16890162
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	CLINT1 CPT1A IPO7 SLC12A9 SNX9 RETREG3 DRG1	5.29e-05	942	37	7	31073040
Pubmed	The aftiphilin/p200/gamma-synergin complex.	CLINT1 SNX9	6.02e-05	11	37	2	15758025
Pubmed	Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7.	IPO7 LMO1	1.31e-04	16	37	2	11528127
Pubmed	T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system.	EPN3 TOB1	1.31e-04	16	37	2	32675240
Pubmed	Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds.	TAF2 IPO7	2.28e-04	21	37	2	12124942
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	EPN3 FRS2 CLINT1 SNX9 EPN2	3.15e-04	565	37	5	25468996
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	ASPM TOB2 CLINT1 LMO1	3.92e-04	326	37	4	17015433
Pubmed	DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.	TAF2 DNAH6	6.41e-04	35	37	2	24515614
Pubmed	Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.	IPO7 TRIM4	9.23e-04	42	37	2	32738194
Cytoband	5q33.3	CLINT1 UBLCP1	3.91e-04	36	37	2	5q33.3
Cytoband	Ensembl 112 genes in cytogenetic band chr12q15	FRS2 BEST3	9.47e-04	56	37	2	chr12q15
Cytoband	Ensembl 112 genes in cytogenetic band chr5q33	CLINT1 UBLCP1	4.11e-03	118	37	2	chr5q33
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	EPN3 TOB1 RETREG3	6.51e-03	473	37	3	chr17q21
Cytoband	Ensembl 112 genes in cytogenetic band chr10q26	DHX32 PSTK	1.21e-02	207	37	2	chr10q26
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	TRIM4 SLC12A9	1.35e-02	219	37	2	chr7q22
GeneFamily	Bestrophins	BEST3 BEST4	8.47e-06	4	22	2	866
GeneFamily	BTG/Tob family	TOB2 TOB1	2.11e-05	6	22	2	1309
GeneFamily	Immunoglobulin like domain containing	FCRL5 ROBO3	2.28e-02	193	22	2	594
ToppCell	droplet-Lung-nan-18m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLINT1 ROBO3 SNX9 DMXL1	1.18e-05	170	37	4	749144a1a869a6bf9acdd227184319083367dc3f
ToppCell	droplet-Lung-nan-18m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLINT1 ROBO3 SNX9 DMXL1	1.18e-05	170	37	4	25d60a62e8f99c31ab64fe6a0c07ccca3df1a7ee
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DHX32 PSTK CPT1A STARD10	1.48e-05	180	37	4	8d9be9cfdf98e5888654a28ab12e5e89f201af00
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GPR137B TOB1 SNX9 CLEC5A	1.98e-05	194	37	4	bde6830a281f7cd7fd1733e40a41ddd2673ba88e
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GPR137B TOB1 SNX9 CLEC5A	2.10e-05	197	37	4	a902aa05e5f711bcfdd9e19749ab636b597eb116
Disease	Mastocytosis	TRABD2B ABCA2	1.04e-03	39	36	2	EFO_0009001
Disease	Kidney Failure, Chronic	NOX4 CPT1A	1.58e-03	48	36	2	C0022661
Disease	Malignant neoplasm of breast	ZCCHC14 DHX32 SLC8A3 FCRL5 CPT1A UBLCP1	1.75e-03	1074	36	6	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLKWRGSIYKLLYRE	BEST3	21	Q8N1M1
LLRWRGSIYKLLYKE	BEST4	21	Q8NFU0
WRHVYKALTLLDYLL	EPN3	71	Q9H201
RYFKVWLYHDGRLLK	CPT1A	341	P50416
RYYKLLKEREDLPIW	DHX32	51	Q7L7V1
RYQLYHWLEKEVIAL	DMXL1	2056	Q9Y485
EKYYVWLQHTLRKKL	CFLAR	461	O15519
IIKIQRWYRAYKTLH	ASPM	1851	Q8IZT6
IKDRYLLKALDKYWH	LMO1	31	P25800
LLEKIWDYLKLVRIY	DRG1	281	Q9Y295
WRRVYKSLLLLAYLI	CLINT1	76	Q14677
VKWRKLGSYEHRIYL	ITIH2	186	P19823
WRHVYKALTLLDYLI	EPN2	71	O95208
WLQDIERHYRKSYLK	C1orf109	141	Q9NX04
KWYHRYLGKEILRET	FCRL5	56	Q96RD9
KKWALHILARLFERY	IPO7	261	O95373
LDDWKPYKLRRLYFI	NOX4	446	Q9NPH5
RWEQEYLYHRELTKI	DNAH6	256	Q9C0G6
ILYTRKRDSVKWHYL	FRS2	46	Q8WU20
KRDSVKWHYLCLRRY	FRS2	51	Q8WU20
YARRAIWDLILKYKP	ABCA2	1156	Q9BZC7
IDLSRFKKLKYLWLH	LRRC72	61	A6NJI9
YVQLWLVLRYRHKRL	GPR137B	61	O60478
RYKHFDWLYERLLVK	SNX9	286	Q9Y5X1
TLYDVLHDIEYRKKW	STARD10	81	Q9Y365
YRHWIKEELDKIVAY	TAF2	391	Q6P1X5
KYFIGLIYHREEKRW	CLEC5A	126	Q9NY25
AVYHRLWDRAYVRLK	RETREG3	206	Q86VR2
ELYWRLKRHLDYVKL	TRABD2B	116	A6NFA1
WKLLRQELLKYLEYF	PSTK	76	Q8IV42
ALYWRRKQRKELSHY	ROBO3	911	Q96MS0
YLLRLDVRKDHVKFW	SLC12A9	516	Q9BXP2
ELERLLKKKYEGHWY	TOB1	31	P50616
ILDWLRKLRLHKYYP	ZCCHC14	301	Q8WYQ9
LDLNHKYWERYLSKK	UBLCP1	301	Q8WVY7
LDWLKYGKRLLVVHY	WSCD1	476	Q658N2
EWKRRLIRLLLYHFK	TRIM4	141	Q9C037
ELERLLKKKYEGHWY	TOB2	31	Q14106
LLAWVADKRLLFYKY	SLC8A3	246	P57103