Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	NCOA3 NCOA6	2.40e-04	21	22	2	GO:0042975
GeneOntologyMolecularFunction	nuclear thyroid hormone receptor binding	NCOA3 NCOA6	6.36e-04	34	22	2	GO:0046966
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-19 ERVK-9	7.54e-04	37	22	2	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-19 ERVK-9	7.95e-04	38	22	2	GO:0070001
GeneOntologyMolecularFunction	chromatin binding	EP400 TRIM24 NCOA3 NCOA6 PBRM1	1.07e-03	739	22	5	GO:0003682
GeneOntologyMolecularFunction	nuclear receptor binding	TRIM24 NCOA3 NCOA6	1.09e-03	187	22	3	GO:0016922
GeneOntologyMolecularFunction	nuclear estrogen receptor binding	NCOA3 NCOA6	1.54e-03	53	22	2	GO:0030331
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	NCOA3 NCOA6	2.04e-03	61	22	2	GO:0030374
GeneOntologyMolecularFunction	transcription coactivator activity	TRIM24 NCOA3 NCOA6	4.30e-03	303	22	3	GO:0003713
GeneOntologyMolecularFunction	N-acyltransferase activity	NMT1 NCOA3	5.58e-03	102	22	2	GO:0016410
GeneOntologyCellularComponent	nuclear protein-containing complex	EP400 SNRPA NCOA3 CASC3 NCOA6 CSTF2T PBRM1	3.75e-04	1377	22	7	GO:0140513
Domain	Bromodomain_CS	TRIM24 PBRM1	3.49e-04	26	20	2	IPR018359
Domain	BROMODOMAIN_1	TRIM24 PBRM1	7.09e-04	37	20	2	PS00633
Domain	Bromodomain	TRIM24 PBRM1	7.48e-04	38	20	2	PF00439
Domain	BROMODOMAIN_2	TRIM24 PBRM1	8.71e-04	41	20	2	PS50014
Domain	BROMO	TRIM24 PBRM1	9.14e-04	42	20	2	SM00297
Domain	Bromodomain	TRIM24 PBRM1	9.14e-04	42	20	2	IPR001487
Domain	-	TRIM24 PBRM1	9.14e-04	42	20	2	1.20.920.10
Domain	Homeodomain-like	EP400 RHOXF2B RHOXF2	5.07e-03	332	20	3	IPR009057
Domain	Homeobox_CS	RHOXF2B RHOXF2	1.67e-02	186	20	2	IPR017970
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	EP400 TRIM24 PBRM1 SALL3	3.03e-04	301	16	4	MM15983
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	EP400 NCOA3 FKBP15 PBRM1 SALL3	5.93e-08	167	22	5	20362541
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	SNRPA NCOA3 CASC3 ZNF207 NCOA6 CSTF2T	2.03e-07	425	22	6	24999758
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	EP400 TRIM24 NCOA3 NCOA6	2.13e-07	83	22	4	28794006
Pubmed	T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.	TRIM24 NCOA3 NCOA6	2.49e-07	20	22	3	11877444
Pubmed	Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer.	NCOA3 NCOA6	3.82e-07	2	22	2	8758910
Pubmed	Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation.	RHOXF2B RHOXF2	3.82e-07	2	22	2	12087094
Pubmed	Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X.	RHOXF2B RHOXF2	3.82e-07	2	22	2	16465597
Pubmed	Rhox homeobox gene cluster: recent duplication of three family members.	RHOXF2B RHOXF2	3.82e-07	2	22	2	16496311
Pubmed	Cloning and characterization of the 5'-flanking region of the Ehox gene.	RHOXF2B RHOXF2	3.82e-07	2	22	2	16414020
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	EP400 TRIM24 NCOA3 NCOA6 PBRM1	6.19e-07	268	22	5	33640491
Pubmed	The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development.	RHOXF2B RHOXF2	1.15e-06	3	22	2	18562707
Pubmed	The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c.	RHOXF2B RHOXF2	1.15e-06	3	22	2	18077458
Pubmed	Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain.	TRIM24 NCOA3	2.29e-06	4	22	2	11851396
Pubmed	Rhox: a new homeobox gene cluster.	RHOXF2B RHOXF2	2.29e-06	4	22	2	15707895
Pubmed	Interaction network of human early embryonic transcription factors.	EP400 TRIM24 NCOA3 NCOA6 PBRM1	2.33e-06	351	22	5	38297188
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EP400 SNRPA TRIM24 NCOA3 ZNF207 NCOA6 CSTF2T	3.56e-06	1103	22	7	34189442
Pubmed	Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm.	RHOXF2B RHOXF2	3.82e-06	5	22	2	14648851
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-19 ERVK-9	5.72e-06	6	22	2	15063128
Pubmed	Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.	DGKB NCOA3	1.37e-05	9	22	2	19176441
Pubmed	Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development.	RHOXF2B RHOXF2	1.71e-05	10	22	2	21972064
Pubmed	The Hippocampal Response to Acute Corticosterone Elevation Is Altered in a Mouse Model for Angelman Syndrome.	NCOA3 NCOA6	2.09e-05	11	22	2	36613751
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EP400 SNRPA TRIM24 ZNF207 NCOA6 SALL3	2.15e-05	954	22	6	36373674
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-19 ERVK-9	2.51e-05	12	22	2	14557543
Pubmed	A major X-linked locus affects kidney function in mice.	RHOXF2B RHOXF2	2.51e-05	12	22	2	23011808
Pubmed	Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice.	RHOXF2B RHOXF2	2.51e-05	12	22	2	29500366
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	EP400 SNRPA NCOA3 FKBP15 CSTF2T PBRM1	3.03e-05	1014	22	6	32416067
Pubmed	Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres.	TRIM24 NCOA3	3.46e-05	14	22	2	11500849
Pubmed	ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis.	RHOXF2B RHOXF2	5.81e-05	18	22	2	33842485
Pubmed	Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.	NCOA3 NCOA6	7.96e-05	21	22	2	19596656
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	EP400 NCOA3	9.59e-05	23	22	2	9225980
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	EP400 TRIM24 PBRM1 SALL3	1.03e-04	396	22	4	26687479
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EP400 NMT1 NCOA3 NCOA6 CSTF2T	1.04e-04	774	22	5	15302935
Pubmed	DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.	RHOXF2B RHOXF2	1.05e-04	24	22	2	17182866
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	EP400 TRIM24 NCOA3 PBRM1	1.05e-04	398	22	4	35016035
Pubmed	A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei.	TRIM24 NCOA3	1.14e-04	25	22	2	21182203
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	TRIM24 NCOA3 ZNF207 PBRM1 SALL3	1.27e-04	808	22	5	20412781
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	EP400 NCOA6 PBRM1	1.30e-04	157	22	3	30186101
Pubmed	Maternal DNA Methylation Regulates Early Trophoblast Development.	RHOXF2B RHOXF2	1.43e-04	28	22	2	26812015
Pubmed	Specification of jaw identity by the Hand2 transcription factor.	RHOXF2B RHOXF2	1.43e-04	28	22	2	27329940
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	TRIM24 NCOA3 ZNF207 NCOA6	1.78e-04	457	22	4	32344865
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	EP400 NCOA3 ZNF207 PBRM1	1.97e-04	469	22	4	27634302
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EP400 NMT1 CASC3 ZNF207 CSTF2T PBRM1	2.59e-04	1497	22	6	31527615
Pubmed	A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.	FKBP15 RHOXF2B RHOXF2	2.86e-04	205	22	3	12040188
Pubmed	Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.	EP400 PBRM1	3.24e-04	42	22	2	35705031
Pubmed	The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.	NCOA3 NCOA6	3.40e-04	43	22	2	26487511
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	TRIM24 NCOA3 PBRM1	3.52e-04	220	22	3	35785414
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	SNRPA NCOA6	4.59e-04	50	22	2	37974198
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	EP400 SNRPA FKBP15 ZNF207 CSTF2T	4.89e-04	1082	22	5	38697112
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	NCOA3 NCOA6 INSRR	5.11e-04	250	22	3	18660489
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	NCOA3 RHOXF2B RHOXF2	5.92e-04	263	22	3	20932939
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TRIM24 NCOA3 NCOA6 PBRM1	6.31e-04	638	22	4	31182584
Interaction	KLF5 interactions	EP400 TRIM24 NCOA3 NCOA6 PBRM1	1.45e-06	195	21	5	int:KLF5
Interaction	FEV interactions	EP400 TRIM24 NCOA3 NCOA6 PBRM1	1.76e-06	203	21	5	int:FEV
Interaction	SOX17 interactions	TRIM24 NCOA3 NCOA6 PBRM1	2.61e-06	95	21	4	int:SOX17
Interaction	SOX9 interactions	EP400 NCOA3 NCOA6 PBRM1	2.83e-06	97	21	4	int:SOX9
Interaction	CRX interactions	EP400 TRIM24 NCOA3 RHOXF2 PBRM1	5.28e-06	254	21	5	int:CRX
Interaction	ETS1 interactions	EP400 TRIM24 NCOA3 PBRM1	6.84e-06	121	21	4	int:ETS1
Interaction	HNF4A interactions	EP400 TRIM24 NCOA3 NCOA6 PBRM1	7.76e-06	275	21	5	int:HNF4A
Interaction	SP7 interactions	EP400 TRIM24 NCOA3 NCOA6 PBRM1	1.26e-05	304	21	5	int:SP7
Interaction	FOS interactions	EP400 TRIM24 NCOA3 NCOA6 PBRM1	1.43e-05	312	21	5	int:FOS
Interaction	EWSR1 interactions	SNRPA NCOA3 CASC3 ZNF207 NCOA6 RHOXF2 CSTF2T	2.42e-05	906	21	7	int:EWSR1
Interaction	EGR2 interactions	EP400 TRIM24 NCOA3 NCOA6	2.68e-05	171	21	4	int:EGR2
Interaction	PAX6 interactions	EP400 TRIM24 NCOA3 NCOA6 PBRM1	3.08e-05	366	21	5	int:PAX6
Interaction	HNF1B interactions	EP400 TRIM24 NCOA3 PBRM1	4.04e-05	190	21	4	int:HNF1B
Interaction	MYOD1 interactions	EP400 TRIM24 NCOA3 PBRM1	4.38e-05	194	21	4	int:MYOD1
Interaction	GATA2 interactions	TRIM24 NCOA3 NCOA6 PBRM1	4.84e-05	199	21	4	int:GATA2
Interaction	SOX7 interactions	TRIM24 NCOA3 PBRM1	8.19e-05	82	21	3	int:SOX7
Interaction	NANOG interactions	EP400 TRIM24 RHOXF2 PBRM1 SALL3	1.12e-04	481	21	5	int:NANOG
Interaction	FOXI1 interactions	TRIM24 NCOA3 CSTF2T	1.15e-04	92	21	3	int:FOXI1
Interaction	KLF6 interactions	EP400 TRIM24 PBRM1	1.27e-04	95	21	3	int:KLF6
Interaction	ESRRB interactions	EP400 NCOA3 FKBP15 PBRM1	1.40e-04	262	21	4	int:ESRRB
Interaction	CEBPA interactions	EP400 SNRPA TRIM24 NCOA3 ZNF207 NCOA6 CSTF2T	1.82e-04	1245	21	7	int:CEBPA
Interaction	THRA interactions	TRIM24 NCOA3 NCOA6	2.01e-04	111	21	3	int:THRA
Interaction	KLF15 interactions	EP400 TRIM24 NCOA3 PBRM1	2.07e-04	290	21	4	int:KLF15
Interaction	TLX3 interactions	TRIM24 NCOA3 NCOA6 PBRM1	2.10e-04	291	21	4	int:TLX3
Interaction	ELF4 interactions	EP400 TRIM24 PBRM1	2.23e-04	115	21	3	int:ELF4
Interaction	TBXT interactions	TRIM24 NCOA3 NCOA6	2.29e-04	116	21	3	int:TBXT
Interaction	PPARG interactions	TRIM24 NCOA3 NCOA6 PBRM1	2.58e-04	307	21	4	int:PPARG
Interaction	ELF1 interactions	EP400 TRIM24 PBRM1	2.92e-04	126	21	3	int:ELF1
Interaction	VDR interactions	TRIM24 NCOA3 NCOA6	2.99e-04	127	21	3	int:VDR
Interaction	PAX9 interactions	NCOA3 NCOA6 PBRM1	3.20e-04	130	21	3	int:PAX9
Interaction	KLF8 interactions	EP400 TRIM24 NCOA3 PBRM1	3.35e-04	329	21	4	int:KLF8
Interaction	SMC5 interactions	EP400 SNRPA TRIM24 ZNF207 NCOA6 SALL3	4.19e-04	1000	21	6	int:SMC5
Interaction	SUZ12 interactions	EP400 SNRPA NCOA3 ZNF207 PBRM1	4.36e-04	644	21	5	int:SUZ12
Interaction	NCOA1 interactions	TRIM24 NCOA3 NCOA6	4.50e-04	146	21	3	int:NCOA1
Interaction	TOP1 interactions	EP400 SNRPA TRIM24 NCOA6 PBRM1	6.22e-04	696	21	5	int:TOP1
Interaction	LHX4 interactions	SNRPA TRIM24 PBRM1	6.55e-04	166	21	3	int:LHX4
Interaction	NUP62CL interactions	TRIM24 FKBP15	6.74e-04	37	21	2	int:NUP62CL
Interaction	RXRA interactions	TRIM24 NCOA3 NCOA6	6.89e-04	169	21	3	int:RXRA
Interaction	SETD1A interactions	ZNF207 NCOA6 INSRR	7.01e-04	170	21	3	int:SETD1A
Interaction	FBF1 interactions	NMT1 FKBP15 RHOXF2	7.13e-04	171	21	3	int:FBF1
Interaction	LHX2 interactions	EP400 TRIM24 PBRM1	8.68e-04	183	21	3	int:LHX2
Interaction	NUP35 interactions	TRIM24 NCOA3 ZNF207 NCOA6	8.70e-04	424	21	4	int:NUP35
Interaction	RNPS1 interactions	SNRPA TRIM24 CASC3 ZNF207	8.78e-04	425	21	4	int:RNPS1
Interaction	RORC interactions	NCOA3 NCOA6	9.97e-04	45	21	2	int:RORC
Interaction	RORB interactions	NCOA3 NCOA6	1.09e-03	47	21	2	int:RORB
Interaction	NR1I3 interactions	TRIM24 NCOA3	1.13e-03	48	21	2	int:NR1I3
Interaction	NR1I2 interactions	NCOA3 NCOA6	1.13e-03	48	21	2	int:NR1I2
Cytoband	Xq24	RHOXF2B RHOXF2	3.95e-04	64	21	2	Xq24
Cytoband	Ensembl 112 genes in cytogenetic band chrXq24	RHOXF2B RHOXF2	6.32e-04	81	21	2	chrXq24
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	NMT1 CASC3	1.95e-02	473	21	2	chr17q21
GeneFamily	Ataxins\|Trinucleotide repeat containing	EP400 NCOA3	2.18e-04	25	16	2	775
GeneFamily	PRD class homeoboxes and pseudogenes	RHOXF2B RHOXF2	2.93e-03	92	16	2	521
GeneFamily	RNA binding motif containing	SNRPA CSTF2T	1.49e-02	213	16	2	725
Drug	Spectinomycin dihydrochloride [21736-83-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A	FKBP15 TNFRSF25 CSTF2T PBRM1	2.32e-05	196	20	4	4773_UP
Drug	Dihydroergotamine tartrate [5989-77-5]; Up 200; 3uM; PC3; HT_HG-U133A	NMT1 NCOA3 TMEM8B FKBP15	2.41e-05	198	20	4	2081_UP
Drug	Prazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; PC3; HT_HG-U133A	NMT1 TMEM8B FKBP15 TNFRSF25	2.41e-05	198	20	4	6315_UP
Drug	Ceftazidime pentahydrate [78439-06-2]; Down 200; 6.2uM; PC3; HT_HG-U133A	TMEM8B FKBP15 TNFRSF25 CSTF2T	2.46e-05	199	20	4	5054_DN
Drug	2-hydroxypalmitic acid	NMT1 NCOA6	2.63e-05	9	20	2	CID000092836
Drug	vinylene	SNRPA TRIM24 ZNF207 SALL3	5.54e-05	245	20	4	CID000006326
Disease	acute lymphoblastic leukemia, response to antineoplastic agent	DGKB NCOA3	5.97e-05	19	18	2	EFO_0000220, GO_0097327
Disease	glucose metabolism disease (implicated_via_orthology)	DGKB INSRR	1.32e-04	28	18	2	DOID:4194 (implicated_via_orthology)
Disease	feeling nervous measurement	NCOA6 PBRM1	1.28e-03	87	18	2	EFO_0009597
Disease	neuroblastoma	DGKB ASAP2	2.25e-03	116	18	2	EFO_0000621
Disease	Malignant neoplasm of breast	NCOA3 CD74 NCOA6 PBRM1	3.55e-03	1074	18	4	C0006142
Disease	Breast Carcinoma	NCOA3 CD74 PBRM1	4.01e-03	538	18	3	C0678222
Disease	Non-Small Cell Lung Carcinoma	NCOA3 CD74	4.02e-03	156	18	2	C0007131
Disease	multiple sclerosis	TMEM8B TNFRSF25 ASAP2	5.29e-03	594	18	3	MONDO_0005301

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLQQLMPTAQGGMPP	EP400	541	Q96L91
VVPPPTPMGMLNQQL	PBRM1	1466	Q86U86
PPAPPLPQMMEGNGN	NMT1	11	P30419
GPLSNAMVLQPPAPM	ASAP2	921	O43150
MGQPMLPILPPQLDS	FKBP15	371	Q5T1M5
LPQNQLMMTGPKPGP	NCOA6	1156	Q14686
PLPPQGMLVQPGMNL	CASC3	566	O15234
NQAPMLMGPPPKTGL	DGKB	776	Q9Y6T7
NPGLPQPALGEMIQM	INSRR	1081	P14616
MQPQLGMPGVGPVPL	CSTF2T	286	Q9H0L4
QALPMGALPQGPMQN	CD74	116	P04233
QTVMGPGLAPMLAPP	SALL3	1091	Q9BXA9
FPMLPKQPMLGGNPR	NCOA3	876	Q9Y6Q9
LPLMLLPPMPPAGQA	RHOXF2B	256	P0C7M4
NAVIQPMGPLQPGLP	ERVK-9	1016	P63128
VGLPNPRMQGPIQQP	TRIM24	491	O15164
MNMPQSLGNQPLPPE	TMEM8B	1	A6NDV4
LPLMLLPPMPPAGQA	RHOXF2	256	Q9BQY4
PAGSPAMMLQPGPQL	TNFRSF25	321	Q93038
PIGGMMPPQPGIPQQ	ZNF207	401	O43670
MPPQPGIPQQQGMRP	ZNF207	406	O43670
GIPQQQGMRPPMPPH	ZNF207	411	O43670
NAVIQPMGPLQPGLP	ERVK-19	96	Q9WJR5
PMGPLQPGLPSLAMI	ERVK-19	101	Q9WJR5
PPGAMPPQQLMPGQM	SNRPA	181	P09012