Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionkinesin binding

KLC4 KLC2 KLC1

1.57e-0555183GO:0019894
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

RGL3 ITSN1 ARHGEF40 ARHGEF28

4.70e-05231184GO:0005085
GeneOntologyMolecularFunctionGTPase regulator activity

RGL3 ITSN1 ARHGEF40 ARHGEF28

9.47e-04507184GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGL3 ITSN1 ARHGEF40 ARHGEF28

9.47e-04507184GO:0060589
GeneOntologyBiologicalProcessdevelopment of secondary male sexual characteristics

STAT5A STAT5B

2.16e-063182GO:0046544
GeneOntologyBiologicalProcesstaurine metabolic process

STAT5A STAT5B

2.58e-059182GO:0019530
GeneOntologyBiologicalProcessalkanesulfonate metabolic process

STAT5A STAT5B

2.58e-059182GO:0019694
GeneOntologyBiologicalProcessgrowth hormone receptor signaling pathway via JAK-STAT

STAT5A STAT5B

3.22e-0510182GO:0060397
GeneOntologyBiologicalProcessdevelopment of secondary female sexual characteristics

STAT5A STAT5B

3.22e-0510182GO:0046543
GeneOntologyBiologicalProcessnegative regulation of erythrocyte differentiation

STAT5A STAT5B

3.94e-0511182GO:0045647
GeneOntologyBiologicalProcessresponse to interleukin-2

STAT5A STAT5B

3.94e-0511182GO:0070669
GeneOntologyBiologicalProcesspositive regulation of natural killer cell differentiation

STAT5A STAT5B

4.72e-0512182GO:0032825
GeneOntologyBiologicalProcessresponse to interleukin-15

STAT5A STAT5B

4.72e-0512182GO:0070672
GeneOntologyBiologicalProcesspositive regulation of gamma-delta T cell differentiation

STAT5A STAT5B

4.72e-0512182GO:0045588
GeneOntologyBiologicalProcessdevelopment of secondary sexual characteristics

STAT5A STAT5B

5.58e-0513182GO:0045136
GeneOntologyBiologicalProcessmucosa-associated lymphoid tissue development

STAT5A STAT5B

5.58e-0513182GO:0048537
GeneOntologyBiologicalProcessPeyer's patch development

STAT5A STAT5B

5.58e-0513182GO:0048541
GeneOntologyBiologicalProcesspositive regulation of gamma-delta T cell activation

STAT5A STAT5B

6.51e-0514182GO:0046645
GeneOntologyBiologicalProcessregulation of gamma-delta T cell differentiation

STAT5A STAT5B

7.50e-0515182GO:0045586
GeneOntologyBiologicalProcessluteinization

STAT5A STAT5B

8.57e-0516182GO:0001553
GeneOntologyBiologicalProcessregulation of gamma-delta T cell activation

STAT5A STAT5B

9.71e-0517182GO:0046643
GeneOntologyBiologicalProcessgamma-delta T cell differentiation

STAT5A STAT5B

1.35e-0420182GO:0042492
GeneOntologyBiologicalProcessregulation of natural killer cell differentiation

STAT5A STAT5B

1.50e-0421182GO:0032823
GeneOntologyBiologicalProcesspositive regulation of B cell differentiation

STAT5A STAT5B

1.50e-0421182GO:0045579
GeneOntologyBiologicalProcesshematopoietic or lymphoid organ development

CD248 STAT5A STAT5B

1.99e-04133183GO:0048534
GeneOntologyBiologicalProcessgrowth hormone receptor signaling pathway

STAT5A STAT5B

2.31e-0426182GO:0060396
GeneOntologyBiologicalProcesscellular response to growth hormone stimulus

STAT5A STAT5B

2.49e-0427182GO:0071378
GeneOntologyBiologicalProcessnegative regulation of myeloid cell apoptotic process

STAT5A STAT5B

2.49e-0427182GO:0033033
GeneOntologyBiologicalProcesspositive regulation of activated T cell proliferation

STAT5A STAT5B

3.51e-0432182GO:0042104
GeneOntologyBiologicalProcessgamma-delta T cell activation

STAT5A STAT5B

3.74e-0433182GO:0046629
GeneOntologyBiologicalProcesspositive regulation of natural killer cell activation

STAT5A STAT5B

4.21e-0435182GO:0032816
GeneOntologyBiologicalProcessnatural killer cell differentiation

STAT5A STAT5B

4.96e-0438182GO:0001779
GeneOntologyBiologicalProcesspositive regulation of natural killer cell mediated cytotoxicity

STAT5A STAT5B

5.50e-0440182GO:0045954
GeneOntologyBiologicalProcessresponse to interleukin-4

STAT5A STAT5B

5.78e-0441182GO:0070670
GeneOntologyBiologicalProcessresponse to growth hormone

STAT5A STAT5B

5.78e-0441182GO:0060416
GeneOntologyBiologicalProcesspositive regulation of interleukin-2 production

STAT5A STAT5B

6.07e-0442182GO:0032743
GeneOntologyBiologicalProcessregulation of myeloid cell apoptotic process

STAT5A STAT5B

6.07e-0442182GO:0033032
GeneOntologyBiologicalProcesspositive regulation of natural killer cell mediated immunity

STAT5A STAT5B

6.66e-0444182GO:0002717
GeneOntologyBiologicalProcessregulation of B cell differentiation

STAT5A STAT5B

7.28e-0446182GO:0045577
GeneOntologyBiologicalProcesspositive regulation of multicellular organism growth

STAT5A STAT5B

7.60e-0447182GO:0040018
GeneOntologyBiologicalProcesslactation

STAT5A STAT5B

7.92e-0448182GO:0007595
GeneOntologyBiologicalProcessregulation of epithelial cell differentiation

STAT5A STAT5B NUMA1

8.34e-04217183GO:0030856
GeneOntologyBiologicalProcessmyeloid cell apoptotic process

STAT5A STAT5B

8.94e-0451182GO:0033028
GeneOntologyBiologicalProcessclathrin-dependent endocytosis

BMP2K ITSN1

9.65e-0453182GO:0072583
GeneOntologyBiologicalProcessregulation of activated T cell proliferation

STAT5A STAT5B

1.00e-0354182GO:0046006
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

RGL3 ITSN1 ARHGEF40 ARHGEF28

1.05e-03538184GO:0007264
GeneOntologyBiologicalProcessT cell homeostasis

STAT5A STAT5B

1.19e-0359182GO:0043029
GeneOntologyBiologicalProcessimmune system development

CD248 STAT5A STAT5B

1.23e-03248183GO:0002520
GeneOntologyBiologicalProcessregulation of erythrocyte differentiation

STAT5A STAT5B

1.24e-0360182GO:0045646
GeneOntologyBiologicalProcessregulation of natural killer cell activation

STAT5A STAT5B

1.28e-0361182GO:0032814
GeneOntologyBiologicalProcessactivated T cell proliferation

STAT5A STAT5B

1.45e-0365182GO:0050798
GeneOntologyBiologicalProcesspositive regulation of defense response

LRCH4 STAT5A STAT5B NPAS2

1.46e-03589184GO:0031349
GeneOntologyBiologicalProcessovulation cycle process

STAT5A STAT5B

1.58e-0368182GO:0022602
GeneOntologyBiologicalProcessregulation of interleukin-2 production

STAT5A STAT5B

1.87e-0374182GO:0032663
GeneOntologyBiologicalProcessregulation of natural killer cell mediated cytotoxicity

STAT5A STAT5B

1.97e-0376182GO:0042269
GeneOntologyBiologicalProcesspositive regulation of leukocyte mediated cytotoxicity

STAT5A STAT5B

2.13e-0379182GO:0001912
GeneOntologyBiologicalProcessregulation of natural killer cell mediated immunity

STAT5A STAT5B

2.18e-0380182GO:0002715
GeneOntologyBiologicalProcessinterleukin-2 production

STAT5A STAT5B

2.29e-0382182GO:0032623
GeneOntologyBiologicalProcesspositive regulation of cell killing

STAT5A STAT5B

2.63e-0388182GO:0031343
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

ITSN1 ARHGEF40 ARHGEF28

2.84e-03333183GO:0051056
GeneOntologyBiologicalProcessregulation of multicellular organism growth

STAT5A STAT5B

2.94e-0393182GO:0040014
GeneOntologyBiologicalProcessovulation cycle

STAT5A STAT5B

3.06e-0395182GO:0042698
GeneOntologyBiologicalProcessaxo-dendritic transport

KLC2 KLC1

3.25e-0398182GO:0008088
GeneOntologyBiologicalProcesspositive regulation of B cell activation

STAT5A STAT5B

3.38e-03100182GO:0050871
GeneOntologyBiologicalProcessrhythmic process

STAT5A STAT5B NPAS2

3.54e-03360183GO:0048511
GeneOntologyBiologicalProcesslymphocyte homeostasis

STAT5A STAT5B

3.65e-03104182GO:0002260
GeneOntologyBiologicalProcesslipid storage

STAT5A STAT5B

3.72e-03105182GO:0019915
GeneOntologyBiologicalProcessnatural killer cell mediated cytotoxicity

STAT5A STAT5B

3.72e-03105182GO:0042267
GeneOntologyBiologicalProcessnatural killer cell mediated immunity

STAT5A STAT5B

4.01e-03109182GO:0002228
GeneOntologyBiologicalProcessT cell differentiation in thymus

STAT5A STAT5B

4.37e-03114182GO:0033077
GeneOntologyBiologicalProcessbody fluid secretion

STAT5A STAT5B

4.91e-03121182GO:0007589
GeneOntologyBiologicalProcesspositive regulation of cell cycle

STAT5A STAT5B NUMA1

4.99e-03407183GO:0045787
GeneOntologyBiologicalProcessregulation of leukocyte mediated cytotoxicity

STAT5A STAT5B

5.15e-03124182GO:0001910
GeneOntologyBiologicalProcessnatural killer cell activation

STAT5A STAT5B

5.15e-03124182GO:0030101
GeneOntologyBiologicalProcesspositive regulation of T cell proliferation

STAT5A STAT5B

5.23e-03125182GO:0042102
GeneOntologyBiologicalProcesspositive regulation of innate immune response

LRCH4 STAT5A STAT5B

5.45e-03420183GO:0045089
GeneOntologyBiologicalProcessnegative regulation of myeloid cell differentiation

STAT5A STAT5B

5.99e-03134182GO:0045638
GeneOntologyBiologicalProcesspositive regulation of myeloid cell differentiation

STAT5A STAT5B

5.99e-03134182GO:0045639
GeneOntologyBiologicalProcessregulation of steroid metabolic process

STAT5A STAT5B

6.07e-03135182GO:0019218
GeneOntologyCellularComponentkinesin complex

KLC4 KLC2 KLC1

9.63e-0649183GO:0005871
GeneOntologyCellularComponentciliary rootlet

KLC2 KLC1

8.34e-0516182GO:0035253
GeneOntologyCellularComponentmicrotubule associated complex

KLC4 KLC2 KLC1

3.36e-04161183GO:0005875
GeneOntologyCellularComponentmicrotubule

KLC4 KLC2 KLC1 NUMA1

9.62e-04533184GO:0005874
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

STAT5A STAT5B NPAS2

1.54e-03272183GO:0090575
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

KLC4 KLC2 KLC1 NUMA1

6.42e-03899184GO:0099513
HumanPhenoMetrorrhagia

STAT5B NUMA1

5.53e-051642HP:0100608
HumanPhenoDiffuse alveolar hemorrhage

STAT5B NUMA1

6.27e-051742HP:0025420
HumanPhenoOral cavity bleeding

STAT5B NUMA1

9.67e-052142HP:0030140
HumanPhenoChronic infection

STAT5B NUMA1

1.16e-042342HP:0031035
HumanPhenoProblematic alcohol consumption

STAT5B NUMA1

1.61e-042742HP:5200329
HumanPhenoAddictive alcohol use

STAT5B NUMA1

1.61e-042742HP:0030955
HumanPhenoAddictive behavior

STAT5B NUMA1

1.61e-042742HP:0030858
HumanPhenoAbnormal alcohol consumption

STAT5B NUMA1

1.61e-042742HP:0430037
HumanPhenoBone marrow hypercellularity

STAT5B NUMA1

1.74e-042842HP:0031020
HumanPhenoDisseminated intravascular coagulation

STAT5B NUMA1

1.86e-042942HP:0005521
HumanPhenoPulmonary hemorrhage

STAT5B NUMA1

2.13e-043142HP:0040223
HumanPhenoHypofibrinogenemia

STAT5B NUMA1

3.94e-044242HP:0011900
HumanPhenoAbnormality of circulating fibrinogen

STAT5B NUMA1

5.15e-044842HP:0011898
HumanPhenoGangrene

STAT5B NUMA1

7.02e-045642HP:0100758
HumanPhenoEcchymosis

STAT5B NUMA1

7.53e-045842HP:0031364
HumanPhenoOral bleeding

STAT5B NUMA1

8.06e-046042HP:0000167
HumanPhenoGingival bleeding

STAT5B NUMA1

8.06e-046042HP:0000225
HumanPhenoPetechiae

STAT5B NUMA1

8.89e-046342HP:0000967
HumanPhenoIrregular menstruation

PHKB STAT5B NUMA1

1.02e-0332943HP:0000858
HumanPhenoAbnormality of the menstrual cycle

PHKB STAT5B NUMA1

1.02e-0332943HP:0000140
HumanPhenoAbnormality of the common coagulation pathway

STAT5B NUMA1

1.04e-036842HP:0010990
HumanPhenoProductive cough

STAT5B NUMA1

1.04e-036842HP:0031245
HumanPhenoStomatitis

STAT5B NUMA1

1.10e-037042HP:0010280
HumanPhenoAbnormal drinking behavior

STAT5B NUMA1

1.47e-038142HP:0030082
HumanPhenoBone pain

STAT5B NUMA1

1.69e-038742HP:0002653
HumanPhenoAbnormal female reproductive system physiology

PHKB STAT5B NUMA1

1.76e-0339643HP:0030012
HumanPhenoMacular purpura

STAT5B NUMA1

1.77e-038942HP:0031365
HumanPhenoEpistaxis

STAT5B NUMA1

2.60e-0310842HP:0000421
HumanPhenoAnorexia

STAT5B NUMA1

3.42e-0312442HP:0002039
HumanPhenoFatigue

PHKB STAT5B NUMA1

3.49e-0350043HP:0012378
HumanPhenoGingival overgrowth

STAT5B NUMA1

3.53e-0312642HP:0000212
HumanPhenoPancytopenia

STAT5B NUMA1

3.69e-0312942HP:0001876
HumanPhenoCellular metachromasia

STAT5B NUMA1

3.81e-0313142HP:0003653
HumanPhenoPurpura

STAT5B NUMA1

3.86e-0313242HP:0000979
HumanPhenoVertigo

STAT5B NUMA1

4.71e-0314642HP:0002321
HumanPhenoExertional dyspnea

STAT5B NUMA1

4.78e-0314742HP:0002875
HumanPhenoAbnormality of glycosaminoglycan metabolism

STAT5B NUMA1

5.10e-0315242HP:0004371
HumanPhenoAbnormality of mucopolysaccharide metabolism

STAT5B NUMA1

5.10e-0315242HP:0011020
HumanPhenoAbnormal circulating polysaccharide concentration

STAT5B NUMA1

5.10e-0315242HP:0011012
HumanPhenoLeukocytosis

STAT5B NUMA1

5.57e-0315942HP:0001974
HumanPhenoCough

STAT5B NUMA1

5.64e-0316042HP:0012735
HumanPhenoAbnormality of the coagulation cascade

STAT5B NUMA1

5.71e-0316142HP:0003256
DomainKinesin_light_repeat

KLC4 KLC2 KLC1

6.26e-103173IPR015792
DomainKINESIN_LIGHT

KLC4 KLC2 KLC1

6.26e-103173PS01160
DomainKinesin_light

KLC4 KLC2 KLC1

2.50e-094173IPR002151
DomainRabaptin_Rab5-bd_dom

KLC4 KLC2 KLC1

1.25e-086173IPR015390
DomainTPR_10

KLC4 KLC2 KLC1

1.25e-086173PF13374
DomainRab5-bind

KLC4 KLC2 KLC1

1.25e-086173PF09311
DomainSTAT_TF_prot_interaction

STAT5A STAT5B

1.63e-057172IPR013799
DomainSTAT_TF_DNA-bd_sub

STAT5A STAT5B

1.63e-057172IPR012345
DomainSTAT

STAT5A STAT5B

1.63e-057172IPR001217
DomainSTAT_TF_coiled-coil

STAT5A STAT5B

1.63e-057172IPR015988
DomainSTAT_int

STAT5A STAT5B

1.63e-057172SM00964
Domain-

STAT5A STAT5B

1.63e-0571722.60.40.630
Domain-

STAT5A STAT5B

1.63e-0571721.10.532.10
DomainSTAT_TF_DNA-bd

STAT5A STAT5B

1.63e-057172IPR013801
DomainSTAT_bind

STAT5A STAT5B

1.63e-057172PF02864
DomainSTAT_alpha

STAT5A STAT5B

1.63e-057172PF01017
DomainSTAT_int

STAT5A STAT5B

1.63e-057172PF02865
Domain-

STAT5A STAT5B

1.63e-0571721.20.1050.20
DomainSTAT_TF_alpha

STAT5A STAT5B

2.18e-058172IPR013800
DomainDH_1

ITSN1 ARHGEF40 ARHGEF28

2.40e-0563173PS00741
DomainDH_2

ITSN1 ARHGEF40 ARHGEF28

3.30e-0570173PS50010
DomainRhoGEF

ITSN1 ARHGEF40 ARHGEF28

3.30e-0570173PF00621
Domain-

ITSN1 ARHGEF40 ARHGEF28

3.45e-05711731.20.900.10
DomainDH-domain

ITSN1 ARHGEF40 ARHGEF28

3.45e-0571173IPR000219
DomainTPR_1

KLC4 KLC2 KLC1

7.01e-0590173PF00515
DomainTPR_1

KLC4 KLC2 KLC1

7.01e-0590173IPR001440
DomainPentatricopeptide_repeat

KLC2 KLC1

1.95e-0423172IPR002885
DomainTPR

KLC4 KLC2 KLC1

2.04e-04129173SM00028
DomainTPR_repeat

KLC4 KLC2 KLC1

2.23e-04133173IPR019734
DomainTPR-contain_dom

KLC4 KLC2 KLC1

3.18e-04150173IPR013026
DomainTPR

KLC4 KLC2 KLC1

4.20e-04165173PS50005
DomainTPR_REGION

KLC4 KLC2 KLC1

4.20e-04165173PS50293
Domain-

KLC4 KLC2 KLC1

8.14e-042071731.25.40.10
Domainp53-like_TF_DNA-bd

STAT5A STAT5B

1.05e-0353172IPR008967
DomainTPR-like_helical_dom

KLC4 KLC2 KLC1

1.15e-03233173IPR011990
Domain-

ITSN1 STAT5A STAT5B

1.59e-032611731.10.238.10
DomainRhoGEF

ITSN1 ARHGEF28

1.71e-0368172SM00325
DomainPH

ITSN1 ARHGEF40 ARHGEF28

1.90e-03278173SM00233
DomainPH_DOMAIN

ITSN1 ARHGEF40 ARHGEF28

1.92e-03279173PS50003
DomainPH_domain

ITSN1 ARHGEF40 ARHGEF28

1.94e-03280173IPR001849
DomainEF-hand-dom_pair

ITSN1 STAT5A STAT5B

2.08e-03287173IPR011992
DomainSH2

STAT5A STAT5B

3.73e-03101172PF00017
DomainSH2

STAT5A STAT5B

4.41e-03110172SM00252
DomainSH2

STAT5A STAT5B

4.49e-03111172PS50001
DomainSH2

STAT5A STAT5B

4.57e-03112172IPR000980
Domain-

STAT5A STAT5B

4.57e-031121723.30.505.10
Domain-

ITSN1 ARHGEF40 ARHGEF28

4.98e-033911732.30.29.30
DomainPH_dom-like

ITSN1 ARHGEF40 ARHGEF28

6.32e-03426173IPR011993
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_ANTEROGRADE_AXONAL_TRANSPORT

KLC4 KLC2 KLC1

8.16e-089153M47699
PathwayREACTOME_RHO_GTPASES_ACTIVATE_KTN1

KLC4 KLC2 KLC1

1.60e-0711153MM15218
PathwayREACTOME_RHO_GTPASES_ACTIVATE_KTN1

KLC4 KLC2 KLC1

1.60e-0711153M27490
PathwayKEGG_MEDICUS_VARIANT_OLIGOMERIC_CONFORMATION_PRPC_TO_ANTEROGRADE_AXONAL_TRANSPORT

KLC4 KLC2 KLC1

2.77e-0713153M47763
PathwayKEGG_MEDICUS_REFERENCE_ANTEROGRADE_AXONAL_TRANSPORT

KLC4 KLC2 KLC1

1.95e-0624153M47671
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT

KLC4 KLC2 KLC1

2.21e-0625153M47775
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_ANTEROGRADE_AXONAL_TRANSPORT

KLC4 KLC2 KLC1

2.21e-0625153M47710
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_ANTEROGRADE_AXONAL_TRANSPORT

KLC4 KLC2 KLC1

2.50e-0626153M47672
PathwayKEGG_MEDICUS_REFERENCE_ARL8_REGULATED_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT

KLC4 KLC2 KLC1

6.25e-0635153M47774
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.05e-055152M48987
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.05e-055152M48986
PathwayKEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.05e-055152M49006
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

1.58e-056152MM15581
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

1.58e-056152MM15621
PathwayKEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

2.21e-057152M47646
PathwayREACTOME_STAT5_ACTIVATION

STAT5A STAT5B

2.21e-057152M27953
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5

STAT5A STAT5B

2.21e-057152M27907
PathwayKEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

2.21e-057152M47430
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

2.21e-057152M47581
PathwayREACTOME_KINESINS

KLC4 KLC2 KLC1

2.76e-0557153MM15714
PathwayREACTOME_KINESINS

KLC4 KLC2 KLC1

3.38e-0561153M977
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

3.79e-059152M27861
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

3.79e-059152MM1419
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

3.79e-059152M8066
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

4.73e-0510152M27898
PathwayREACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS

STAT5A STAT5B

4.73e-0510152M41731
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B

4.73e-0510152MM15618
PathwayREACTOME_SIGNALING_BY_LEPTIN

STAT5A STAT5B

5.78e-0511152M27195
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

STAT5A STAT5B

5.78e-0511152MM15578
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

KLC4 KLC2 ITSN1 ARHGEF40 KLC1 ARHGEF28

5.85e-05720156M41838
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B

6.93e-0512152M27893
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

STAT5A STAT5B

9.55e-0514152M27858
PathwayPID_IL5_PATHWAY

STAT5A STAT5B

9.55e-0514152M135
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

STAT5A STAT5B

1.10e-0415152M552
PathwayBIOCARTA_IL3_PATHWAY

STAT5A STAT5B

1.10e-0415152MM1412
PathwayBIOCARTA_IL3_PATHWAY

STAT5A STAT5B

1.10e-0415152M17681
PathwayWP_FOXP3_IN_COVID19

STAT5A STAT5B

1.10e-0415152M42573
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

STAT5A STAT5B

1.10e-0415152MM14536
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B

1.26e-0416152M1296
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B

1.26e-0416152MM1420
PathwayREACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS

STAT5A STAT5B

1.26e-0416152M41733
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

STAT5A STAT5B

1.26e-0416152MM15710
PathwayREACTOME_COPI_DEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC

KLC4 KLC2 KLC1

1.40e-0498153MM15352
PathwayWP_IL9_SIGNALING

STAT5A STAT5B

1.42e-0417152M39644
PathwayKEGG_MEDICUS_REFERENCE_HORMONE_LIKE_CYTOKINE_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.42e-0417152M47905
PathwayREACTOME_COPI_DEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC

KLC4 KLC2 KLC1

1.48e-04100153M27650
PathwayREACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS

STAT5A STAT5B

1.60e-0418152M673
PathwayBIOCARTA_EPO_PATHWAY

STAT5A STAT5B

1.79e-0419152M12836
PathwayREACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS

STAT5A STAT5B

1.79e-0419152M41732
PathwayREACTOME_INTERLEUKIN_20_FAMILY_SIGNALING

STAT5A STAT5B

1.99e-0420152MM15496
PathwayBIOCARTA_EPO_PATHWAY

STAT5A STAT5B

1.99e-0420152MM1389
PathwayREACTOME_SIGNALING_BY_KIT_IN_DISEASE

STAT5A STAT5B

1.99e-0420152M39002
PathwayREACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION

KLC4 KLC2 KLC1

2.30e-04116153MM14855
PathwayREACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION

KLC4 KLC2 KLC1

2.30e-04116153MM15715
PathwayBIOCARTA_IL2_PATHWAY

STAT5A STAT5B

2.41e-0422152M7747
PathwayBIOCARTA_IL2_PATHWAY

STAT5A STAT5B

2.64e-0423152MM1411
PathwayBIOCARTA_GLEEVEC_PATHWAY

STAT5A STAT5B

2.64e-0423152MM1424
PathwayKEGG_MEDICUS_REFERENCE_IL2_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

2.64e-0423152M47904
PathwayBIOCARTA_GLEEVEC_PATHWAY

STAT5A STAT5B

2.64e-0423152M7897
PathwayBIOCARTA_TPO_PATHWAY

STAT5A STAT5B

2.88e-0424152M11520
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

STAT5A STAT5B

2.88e-0424152M519
PathwayREACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION

KLC4 KLC2 KLC1

2.93e-04126153M705
PathwayREACTOME_SIGNALING_BY_ERYTHROPOIETIN

STAT5A STAT5B

3.13e-0425152M27865
PathwayREACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING

STAT5A STAT5B

3.13e-0425152M41829
PathwayBIOCARTA_TPO_PATHWAY

STAT5A STAT5B

3.13e-0425152MM1519
PathwayWP_IL7_SIGNALING

STAT5A STAT5B

3.13e-0425152M39499
PathwayREACTOME_GOLGI_TO_ER_RETROGRADE_TRANSPORT

KLC4 KLC2 KLC1

3.29e-04131153MM15497
PathwayWP_EPO_RECEPTOR_SIGNALING

STAT5A STAT5B

3.38e-0426152M39687
PathwayREACTOME_INTERLEUKIN_20_FAMILY_SIGNALING

STAT5A STAT5B

3.38e-0426152M27750
PathwayPID_IL3_PATHWAY

STAT5A STAT5B

3.38e-0426152M182
PathwayWP_EPO_RECEPTOR_SIGNALING

STAT5A STAT5B

3.38e-0426152MM15896
PathwayREACTOME_GOLGI_TO_ER_RETROGRADE_TRANSPORT

KLC4 KLC2 KLC1

3.51e-04134153M27751
PathwayREACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION

STAT5A STAT5B

3.65e-0427152MM14712
PathwayBIOCARTA_GH_PATHWAY

STAT5A STAT5B

3.65e-0427152M9043
PathwayREACTOME_FLT3_SIGNALING_IN_DISEASE

STAT5A STAT5B

3.93e-0428152M41724
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

KLC4 KLC2 ITSN1 KLC1 ARHGEF28

4.16e-04649155MM15690
PathwayWP_PDGFRBETA_PATHWAY

STAT5A STAT5B

4.22e-0429152M39616
PathwayREACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION

STAT5A STAT5B

4.22e-0429152M779
PathwayREACTOME_SIGNALING_BY_CSF3_G_CSF

STAT5A STAT5B

4.52e-0430152M41825
PathwayPID_IL2_STAT5_PATHWAY

STAT5A STAT5B

4.52e-0430152M234
PathwayREACTOME_FGFR1_MUTANT_RECEPTOR_ACTIVATION

STAT5A STAT5B

4.83e-0431152M661
PathwayWP_WHITE_FAT_CELL_DIFFERENTIATION

STAT5A STAT5B

5.15e-0432152M39333
PathwayWP_WHITE_FAT_CELL_DIFFERENTIATION

STAT5A STAT5B

5.47e-0433152MM15869
PathwayBIOCARTA_GH_PATHWAY

STAT5A STAT5B

5.47e-0433152MM1404
PathwayPID_EPO_PATHWAY

STAT5A STAT5B

5.47e-0433152M233
PathwayWP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS

STAT5A STAT5B

5.81e-0434152M48081
PathwayREACTOME_INTERLEUKIN_2_FAMILY_SIGNALING

STAT5A STAT5B

6.16e-0435152MM15144
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

STAT5A STAT5B

6.52e-0436152M542
PathwayBIOCARTA_IL2RB_PATHWAY

STAT5A STAT5B

6.52e-0436152MM1418
PathwayPID_GMCSF_PATHWAY

STAT5A STAT5B

6.52e-0436152M22
PathwayREACTOME_SIGNALING_BY_SCF_KIT

STAT5A STAT5B

6.89e-0437152MM14564
PathwayBIOCARTA_IL2RB_PATHWAY

STAT5A STAT5B

6.89e-0437152M8615
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

ITSN1 ARHGEF28

6.89e-0437152MM15022
PathwayREACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION

KLC4 KLC2 KLC1

7.05e-04170153M941
PathwayREACTOME_FLT3_SIGNALING

STAT5A STAT5B

7.27e-0438152M29803
PathwayREACTOME_SIGNALING_BY_FGFR1_IN_DISEASE

STAT5A STAT5B

7.27e-0438152M27536
PathwayPID_ERBB4_PATHWAY

STAT5A STAT5B

7.27e-0438152M13
PathwayWP_IL5_SIGNALING

STAT5A STAT5B

8.05e-0440152M39392
PathwayREACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING

STAT5A STAT5B

8.46e-0441152MM15162
PathwayPID_TCPTP_PATHWAY

STAT5A STAT5B

8.88e-0442152M91
Pubmed

The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos.

KLC4 KLC2 KLC1

2.55e-081218316018997
Pubmed

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.

KLC4 KLC2 PHKB KLC1

1.09e-078718417979178
Pubmed

A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities.

STAT5A STAT5B

2.53e-0721829852045
Pubmed

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

STAT5A STAT5B

2.53e-07218223275557
Pubmed

Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.

STAT5A STAT5B

2.53e-07218231599926
Pubmed

Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.

STAT5A STAT5B

2.53e-07218223151802
Pubmed

Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.

STAT5A STAT5B

2.53e-07218228500076
Pubmed

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

STAT5A STAT5B

2.53e-07218226999798
Pubmed

STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.

STAT5A STAT5B

2.53e-07218221826656
Pubmed

Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.

STAT5A STAT5B

2.53e-07218219966185
Pubmed

Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.

STAT5A STAT5B

2.53e-07218221704724
Pubmed

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

STAT5A STAT5B

2.53e-07218210594041
Pubmed

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.

STAT5A STAT5B

2.53e-07218221036145
Pubmed

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.

STAT5A STAT5B

2.53e-07218211867689
Pubmed

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

STAT5A STAT5B

2.53e-07218210486277
Pubmed

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

STAT5A STAT5B

2.53e-0721827720707
Pubmed

Prognostic significance of signal transducer and activator of transcription 5 and 5b expression in Epstein-Barr virus-positive patients with chronic lymphocytic leukemia.

STAT5A STAT5B

2.53e-07218227367207
Pubmed

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.

STAT5A STAT5B

2.53e-07218215980098
Pubmed

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

STAT5A STAT5B

2.53e-07218220233708
Pubmed

STAT5A and STAT5B have opposite correlations with drug response gene expression.

STAT5A STAT5B

2.53e-07218227264955
Pubmed

Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

STAT5A STAT5B

2.53e-07218216775227
Pubmed

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

STAT5A STAT5B

2.53e-07218216493008
Pubmed

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

STAT5A STAT5B

2.53e-07218231443474
Pubmed

STAT5 isoforms: controversies and clarifications.

STAT5A STAT5B

2.53e-07218217447893
Pubmed

Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

STAT5A STAT5B

2.53e-07218224335105
Pubmed

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.

STAT5A STAT5B

2.53e-07218238618957
Pubmed

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.

STAT5A STAT5B

2.53e-07218215340066
Pubmed

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

STAT5A STAT5B

2.53e-0721828816482
Pubmed

Brain STAT5 signaling modulates learning and memory formation.

STAT5A STAT5B

2.53e-07218229460051
Pubmed

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

STAT5A STAT5B

2.53e-07218212377952
Pubmed

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

STAT5A STAT5B

2.53e-07218216840779
Pubmed

The role of STAT proteins in growth hormone signaling.

STAT5A STAT5B

2.53e-07218210851057
Pubmed

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

STAT5A STAT5B

2.53e-07218228806763
Pubmed

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.

STAT5A STAT5B

2.53e-07218222159083
Pubmed

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.

STAT5A STAT5B

2.53e-07218215128421
Pubmed

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.

STAT5A STAT5B

2.53e-07218229105654
Pubmed

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

STAT5A STAT5B

2.53e-07218230377054
Pubmed

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

STAT5A STAT5B

2.53e-07218223565285
Pubmed

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

STAT5A STAT5B

2.53e-07218232790723
Pubmed

Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.

STAT5A STAT5B

2.53e-0721828732682
Pubmed

In vivo identification of novel STAT5 target genes.

STAT5A STAT5B

2.53e-07218218492722
Pubmed

STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.

STAT5A STAT5B

2.53e-07218217003334
Pubmed

How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5.

STAT5A STAT5B

2.53e-07218226717567
Pubmed

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.

STAT5A STAT5B

2.53e-07218210066807
Pubmed

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

STAT5A STAT5B

2.53e-07218220008792
Pubmed

Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.

STAT5A STAT5B

2.53e-07218210835485
Pubmed

Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context.

STAT5A STAT5B

2.53e-07218217438530
Pubmed

Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.

KLC2 KLC1

2.53e-07218229036226
Pubmed

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.

STAT5A STAT5B

2.53e-07218235464049
Pubmed

Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors.

STAT5A STAT5B

2.53e-07218215677477
Pubmed

A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling.

STAT5A STAT5B

2.53e-07218216757175
Pubmed

Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression.

STAT5A STAT5B

2.53e-07218215677453
Pubmed

STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.

STAT5A STAT5B

2.53e-07218233199496
Pubmed

The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.

STAT5A STAT5B

2.53e-07218232281944
Pubmed

Haploinsufficiency identifies STAT5 as a modifier of IL-7-induced lymphomas.

STAT5A STAT5B

2.53e-07218215870688
Pubmed

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

STAT5A STAT5B

2.53e-07218228606561
Pubmed

Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A.

STAT5A STAT5B

2.53e-07218219833766
Pubmed

Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus.

STAT5A STAT5B

2.53e-07218217317776
Pubmed

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

STAT5A STAT5B

2.53e-07218218286195
Pubmed

STAT5A/B gene locus undergoes amplification during human prostate cancer progression.

STAT5A STAT5B

2.53e-07218223660011
Pubmed

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.

STAT5A STAT5B

2.53e-07218221127177
Pubmed

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.

STAT5A STAT5B

2.53e-07218223773921
Pubmed

Role of Stat5 in type I interferon-signaling and transcriptional regulation.

STAT5A STAT5B

2.53e-07218212901872
Pubmed

The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

STAT5A STAT5B

2.53e-07218216289657
Pubmed

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

STAT5A STAT5B

2.53e-0721828631883
Pubmed

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

STAT5A STAT5B

2.53e-07218211030348
Pubmed

Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.

STAT5A STAT5B

2.53e-07218224878107
Pubmed

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

STAT5A STAT5B

2.53e-07218225552366
Pubmed

Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis.

STAT5A STAT5B

2.53e-07218220415542
Pubmed

Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.

STAT5A STAT5B

2.53e-07218234818373
Pubmed

Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells.

STAT5A STAT5B

2.53e-07218223332799
Pubmed

Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.

KLC2 KLC1

2.53e-07218222470497
Pubmed

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.

STAT5A STAT5B

2.53e-07218212393407
Pubmed

Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.

STAT5A STAT5B

2.53e-07218212847485
Pubmed

Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.

STAT5A STAT5B

2.53e-07218225470773
Pubmed

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.

STAT5A STAT5B

2.53e-07218212835478
Pubmed

[Effect of STAT5 gene silencing on the proliferation of T lymphocytes in a mouse model of asthma].

STAT5A STAT5B

2.53e-07218222455944
Pubmed

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

STAT5A STAT5B

2.53e-0721827568026
Pubmed

Identification of STAT5A and STAT5B target genes in human T cells.

STAT5A STAT5B

2.53e-07218224497979
Pubmed

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.

STAT5A STAT5B

2.53e-07218212039059
Pubmed

The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients.

STAT5A STAT5B

2.53e-07218232041920
Pubmed

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.

STAT5A STAT5B

2.53e-07218228074064
Pubmed

Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting.

STAT5A STAT5B

2.53e-07218223465551
Pubmed

STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells.

STAT5A STAT5B

2.53e-07218211756158
Pubmed

STAT5b: A master regulator of key biological pathways.

STAT5A STAT5B

2.53e-07218236755813
Pubmed

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

STAT5A STAT5B

2.53e-07218217536022
Pubmed

STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line.

STAT5A STAT5B

2.53e-07218217382296
Pubmed

STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output.

STAT5A STAT5B

2.53e-07218217976521
Pubmed

Neuronal STAT5 signaling is required for maintaining lactation but not for postpartum maternal behaviors in mice.

STAT5A STAT5B

2.53e-07218225896118
Pubmed

The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.

STAT5A STAT5B

2.53e-07218216502315
Pubmed

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation.

STAT5A STAT5B

2.53e-07218217911616
Pubmed

Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes.

STAT5A STAT5B

2.53e-07218222319210
Pubmed

STAT5 signaling in sexually dimorphic gene expression and growth patterns.

STAT5A STAT5B

2.53e-07218210486314
Pubmed

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

STAT5A STAT5B

2.53e-07218217599554
Pubmed

Constitutively active Stat5A and Stat5B promote adipogenesis.

STAT5A STAT5B

2.53e-07218221431790
Pubmed

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

STAT5A STAT5B

2.53e-07218224497923
Pubmed

Stat5: an essential regulator of mast cell biology.

STAT5A STAT5B

2.53e-07218212217382
Pubmed

Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.

STAT5A STAT5B

2.53e-07218225333863
Pubmed

Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction.

STAT5A STAT5B

2.53e-07218210428030
Pubmed

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.

STAT5A STAT5B

2.53e-07218216115927
InteractionKIF5C interactions

KLC4 KLC2 ITSN1 KLC1

9.91e-0788184int:KIF5C
InteractionAZIN1 interactions

KLC4 KLC2 KLC1

1.05e-0623183int:AZIN1
InteractionKIF5A interactions

KLC4 KLC2 ITSN1 KLC1

1.53e-0698184int:KIF5A
InteractionFHIP1A interactions

KLC4 KLC2 KLC1

3.21e-0633183int:FHIP1A
InteractionFHIP2B interactions

KLC4 KLC2 KLC1

3.52e-0634183int:FHIP2B
InteractionAPEX1 interactions

KLC4 KLC2 BMP2K ITSN1 KLC1 ARHGEF28 HNRNPUL1 NUMA1

6.06e-061271188int:APEX1
InteractionMYCL interactions

KLC4 KLC2 KLC1

1.01e-0548183int:MYCL
InteractionFHIP2A interactions

KLC4 KLC2 KLC1

1.61e-0556183int:FHIP2A
InteractionKPTN interactions

KLC4 KLC2 KLC1

1.98e-0560183int:KPTN
InteractionTRAK2 interactions

KLC4 KLC2 KLC1

2.19e-0562183int:TRAK2
InteractionRUNDC3A interactions

BMP2K TSGA10IP ITSN1

2.30e-0563183int:RUNDC3A
InteractionKLC1 interactions

KLC4 KLC2 KLC1 NUMA1

6.66e-05255184int:KLC1
InteractionNUP62 interactions

KLC4 KLC2 ITSN1 NUMA1

8.68e-05273184int:NUP62
InteractionSYNE4 interactions

KLC4 KLC2 KLC1

9.44e-05101183int:SYNE4
InteractionLMTK2 interactions

KLC4 KLC2 KLC1

1.09e-04106183int:LMTK2
InteractionKLC3 interactions

KLC4 KLC2 KLC1

1.22e-04110183int:KLC3
InteractionEP300 interactions

KLC2 KLC1 STAT5A STAT5B HNRNPUL1 NUMA1 NPAS2

1.24e-041401187int:EP300
InteractionCLSTN1 interactions

KLC4 KLC2 KLC1

1.35e-04114183int:CLSTN1
InteractionKLC4 interactions

KLC4 KLC2 KLC1

1.78e-04125183int:KLC4
InteractionIL7R interactions

STAT5A STAT5B HNRNPUL1

2.53e-04141183int:IL7R
InteractionARHGEF9 interactions

TSGA10IP ARHGEF28

2.61e-0427182int:ARHGEF9
InteractionPARD6B interactions

EME1 KLC1 NUMA1

2.81e-04146183int:PARD6B
InteractionYWHAQ interactions

KLC4 KLC2 KLC1 ARHGEF28 HNRNPUL1 NUMA1

3.00e-041118186int:YWHAQ
InteractionCLIP2 interactions

KLC4 ITSN1

3.02e-0429182int:CLIP2
InteractionGPSM2 interactions

ARHGEF40 NUMA1

3.45e-0431182int:GPSM2
InteractionPRLR interactions

STAT5A STAT5B

3.45e-0431182int:PRLR
InteractionMCMBP interactions

KLC1 STAT5B NUMA1

3.47e-04157183int:MCMBP
InteractionPTPN23 interactions

KLC2 ITSN1 KLC1

3.81e-04162183int:PTPN23
InteractionSTAP2 interactions

STAT5A STAT5B

3.91e-0433182int:STAP2
InteractionCOG6 interactions

KLC4 KLC2 KLC1

3.95e-04164183int:COG6
InteractionREPS2 interactions

BMP2K ITSN1

4.16e-0434182int:REPS2
InteractionS100A2 interactions

KLC4 KLC2 EME1 KLC1

4.20e-04412184int:S100A2
InteractionNAA10 interactions

TSGA10IP KLC1 NUMA1

4.23e-04168183int:NAA10
InteractionKLC2 interactions

KLC4 KLC2 KLC1

4.54e-04172183int:KLC2
InteractionIL2RB interactions

STAT5A STAT5B

4.66e-0436182int:IL2RB
InteractionRUSC2 interactions

KLC2 KLC1

5.20e-0438182int:RUSC2
InteractionCPAP interactions

KLC2 STAT5A STAT5B

5.35e-04182183int:CPAP
InteractionCEP43 interactions

KLC4 KLC2 KLC1

6.06e-04190183int:CEP43
InteractionRBMX interactions

KLC2 KLC1 STAT5A HNRNPUL1

6.41e-04461184int:RBMX
InteractionARMC5 interactions

KLC4 KLC2 HNRNPUL1

7.14e-04201183int:ARMC5
InteractionLRRC31 interactions

PHKB ARHGEF40 NUMA1

7.56e-04205183int:LRRC31
InteractionCCR5 interactions

STAT5A STAT5B

8.64e-0449182int:CCR5
InteractionEPOR interactions

STAT5A STAT5B

9.00e-0450182int:EPOR
InteractionGHR interactions

STAT5A STAT5B

9.36e-0451182int:GHR
InteractionKIF2B interactions

KLC4 KLC1

9.73e-0452182int:KIF2B
InteractionBFSP1 interactions

KLC2 ITSN1

9.73e-0452182int:BFSP1
InteractionIL2RA interactions

STAT5A STAT5B

1.05e-0354182int:IL2RA
InteractionCD247 interactions

STAT5A STAT5B

1.09e-0355182int:CD247
InteractionANAPC2 interactions

KLC4 KLC2 KLC1

1.11e-03234183int:ANAPC2
InteractionAP1B1 interactions

BMP2K TSGA10IP ITSN1

1.15e-03237183int:AP1B1
InteractionCEBPB interactions

KLC2 KLC1 STAT5A STAT5B HNRNPUL1 NUMA1

1.17e-031443186int:CEBPB
InteractionHOOK1 interactions

KLC4 KLC2 KLC1

1.19e-03240183int:HOOK1
InteractionMAPK8IP1 interactions

KLC1 ARHGEF28

1.21e-0358182int:MAPK8IP1
InteractionSCOC interactions

ITSN1 NUMA1

1.25e-0359182int:SCOC
InteractionCROCC interactions

KLC2 KLC1

1.25e-0359182int:CROCC
InteractionROPN1 interactions

TSGA10IP HNRNPUL1

1.34e-0361182int:ROPN1
InteractionHSPA4L interactions

KLC2 ITSN1 NUMA1

1.34e-03250183int:HSPA4L
InteractionNAA40 interactions

KLC4 KLC2 KLC1 HNRNPUL1 NUMA1

1.34e-03978185int:NAA40
InteractionPRPS2 interactions

KLC4 KLC2 KLC1

1.39e-03253183int:PRPS2
InteractionNECAP2 interactions

BMP2K ITSN1

1.42e-0363182int:NECAP2
InteractionFCHSD2 interactions

TSGA10IP ITSN1

1.52e-0365182int:FCHSD2
InteractionYWHAB interactions

KLC4 KLC2 KLC1 ARHGEF28 HNRNPUL1

1.58e-031014185int:YWHAB
InteractionMAPK8IP3 interactions

KLC2 KLC1

1.76e-0370182int:MAPK8IP3
InteractionS100P interactions

KLC4 KLC2 EME1

1.84e-03279183int:S100P
InteractionPPP4R3B interactions

KLC2 KLC1

1.86e-0372182int:PPP4R3B
CytobandEnsembl 112 genes in cytogenetic band chr11q13

CD248 KLC2 TSGA10IP NUMA1

2.59e-05454184chr11q13
CytobandEnsembl 112 genes in cytogenetic band chr17q21

EME1 STAT5A STAT5B

7.90e-04473183chr17q21
Cytoband17q11.2

STAT5A STAT5B

8.49e-0411018217q11.2
Cytoband11q13

CD248 NUMA1

9.76e-0411818211q13
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

KLC4 KLC2 KLC1

2.05e-0511593769
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ITSN1 ARHGEF40

4.65e-046692722
GeneFamilySH2 domain containing

STAT5A STAT5B

1.08e-0310192741
CoexpressionGSE35685_CD34POS_CD38NEG_VS_CD34POS_CD10NEG_CD62LPOS_BONE_MARROW_DN

BMP2K ITSN1 STAT5A STAT5B

9.26e-06200184M9084
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD248 KLC2 BMP2K

4.52e-05175183427a7ee92fe16a90625946492062d37aa0f7235b
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD248 KLC2 BMP2K

4.52e-051751831d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

RGL3 ARHGEF28 NPAS2

5.25e-05184183fa4915b0498f3069fd5ef497286445528f75187e
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BMP2K ARHGEF40 STAT5A

5.33e-0518518319fa853f6f746ccf232a343b3c9c7a5e55800409
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RGL3 ARHGEF28 NPAS2

5.42e-05186183bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RGL3 ARHGEF28 NPAS2

5.51e-05187183db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RGL3 ARHGEF28 NPAS2

6.14e-05194183c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RGL3 ARHGEF28 NPAS2

6.24e-05195183f08e41706680881ebd0afcd08a02f8ac0089f04e
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RGL3 ARHGEF28 NPAS2

6.43e-051971832f91b3870a7058168093a143110954c07588cfe9
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RGL3 ARHGEF28 NPAS2

6.43e-051971836852a8ec1397811bbdd1fc625c52ed4fa75a931e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

CD248 STAT5A ARHGEF28

6.72e-05200183aafe594c88710f8c53d59667cdac5035e08f5511
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

CD248 STAT5A ARHGEF28

6.72e-05200183a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

CD248 NUMA1

6.60e-04951823d6b97576ce4e7a3e495cbc7246ea8c0b2a386f7
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

BMP2K ARHGEF40

7.17e-0499182a815a887094204de30b299e8907e81ad9a39c016
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like-AT2_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGL3 ARHGEF28

8.06e-041051829ed5482b445eacf16d5769f79438098b0e71123a
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGL3 ARHGEF28

1.23e-031301826434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGEF28 NPAS2

1.32e-031351820e5dfbe79598fc7822a7b3baa8d7dba3c9da1dad
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

EME1 ARHGEF28

1.44e-03141182399380de5ea09e22fd128e3e55fffeffc4874c15
ToppCellMild/Remission-B_naive-5|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ITSN1 NPAS2

1.46e-03142182fc5fc2d2b4b976358b8ce762c1f440b20db84103
ToppCellMild/Remission-B_naive-5|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ITSN1 NPAS2

1.59e-031481828b60f9843505660b3c9d5c7792976f902be4b94c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BMP2K ARHGEF40

1.70e-0315318283942ef63d21725fa15ed5a91481d1f9936e8f11
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

EME1 RGL3

1.78e-0315718243a6b423fd70479822a564ff4225a1e4951ae5ed
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-pDC_progenitor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TSGA10IP ARHGEF40

1.78e-0315718262f029831c420d3e9580822177545eb7fdf4d0a3
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

EME1 RGL3

1.78e-03157182f6210be2362d833c6d869ff921188bfc85dda11d
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma|TCGA-Bladder / Sample_Type by Project: Shred V9

RGL3 NPAS2

1.81e-03158182dc559503bab3ec1b9ea54ef2e896d1be33e5344c
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLC4 BMP2K

1.81e-031581821d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD248 STAT5A

1.85e-0316018214dfa519e68bab4bce890ddb66fa7763f18d9f19
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD248 STAT5A

1.85e-031601825b7789d4668ed7732babedc32d812233b430e0bd
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BMP2K ARHGEF40

1.85e-03160182fe9970c160159b35f6599ed13c89cfb49264d554
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD248 STAT5A

1.85e-03160182bba1486faaad5299e10f4fe17c6d149c28dc2560
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD248 STAT5A

1.85e-03160182839bbdfd4e4c7b48260c8bfb7670378634405e1d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Mast_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BMP2K STAT5A

1.88e-03161182c54010d88f1ecb6e0235bb66084876a4d5bf1ecd
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF28 NPAS2

1.94e-03164182b6beb8548ac0dd07e8a580a938e5ee4bf25a3c1f
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-B_cells-CLP|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSGA10IP STAT5A

1.94e-03164182f5cacd7b2329cb0c7c1696eb4d8f89a4bbd9dda1
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF28 NPAS2

1.94e-03164182fe11fcce4ba7f44ba2989ea3705916b67e75f8e7
ToppCellP28-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STAT5B ARHGEF28

2.04e-031681828c8dbdbc7053f34e4ca0c5067af502fbea109fc1
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

KLC2 EME1

2.06e-03169182a949f547b53126a208819bade74a1ac9b2a36ea7
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

KLC2 EME1

2.06e-03169182195d5cd60d646ac6d40a3321b2f739917e7aef14
ToppCelldroplet-Marrow-nan-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP2K HNRNPUL1

2.06e-031691825f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCelldroplet-Skin-nan-18m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD248 ARHGEF40

2.09e-0317018210e0912dd0beab5d0bbe2bd49e477b5962687925
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CD248 RGL3

2.11e-03171182a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell3'_v3-GI_small-bowel-Mast-Mast_cell_granulo-myelo|GI_small-bowel / Manually curated celltypes from each tissue

BMP2K ARHGEF40

2.14e-031721823df11aefc09762fd1f94441324551178e030b249
ToppCellLV-11._Adipocyte|LV / Chamber and Cluster_Paper

ITSN1 STAT5A

2.16e-03173182c2d3fcb3de71015d03d14c63450853d2b03ffa71
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

ARHGEF28 NPAS2

2.18e-031741827d2f802f493f19a068e097b2909a9000e2160266
ToppCell10x3'2.3-week_17-19-Lymphocytic_T-T_NK-CD8_T_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CD248 NPAS2

2.18e-03174182fee2ee3e888ce71f9f3f05d7dc8aaa9549480205
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP2K ARHGEF40

2.21e-0317518291cb819a1786020713b7e64480de0545380daae9
ToppCellpdx-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

KLC4 ARHGEF28

2.23e-031761821e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD248 EME1

2.23e-0317618266c9c6b59030f67e8d746a9c6930e50923f2ded1
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD248 EME1

2.23e-03176182b4a23d8d1414434adeb237a96f28c825f1aebd77
ToppCellfacs-Lung-nan-3m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHKB ARHGEF28

2.26e-03177182b37d821f4f3204daf7c568ac17a0af0ba97273d6
ToppCellfacs-BAT-Fat-3m-Epithelial-nan|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGL3 NPAS2

2.26e-031771827480e522cfae3f5c6c62720083750f8273725ab5
ToppCellfacs-BAT-Fat-3m-Epithelial|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGL3 NPAS2

2.26e-031771823e42f6236962dd9bb23dc0d09b460ec8347d1056
ToppCellfacs-Lung-nan-3m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHKB ARHGEF28

2.26e-03177182e5070934c674a46e070b0d52b9a374516bf6aea1
ToppCellfacs-BAT-Fat-3m-Epithelial-epithelial_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGL3 NPAS2

2.26e-03177182128186bc996784e670194c07c5352e69af5f6d68
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGL3 ARHGEF28

2.26e-031771829b4c1ca5c6fca9a7a936dad49a04155903ef9c32
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

KLC4 KLC1

2.26e-0317718236b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD248 RGL3

2.28e-03178182e5e4742e35c3d90f82b830d77bdbdc45828c7deb
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_2|390C / Donor, Lineage, Cell class and subclass (all cells)

KLC4 EME1

2.28e-03178182829ea00c022a78d1861aa3ec53503272976775d9
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHKB EME1

2.31e-031791824166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP2K STAT5A

2.31e-031791821b979e0203a2ddfe98bf6c2c80c4af1ba437a80f
ToppCellfacs-Lung-EPCAM-24m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP2K STAT5A

2.31e-0317918251872338e54c5f3e42ca9f1c4cf1e8b0cb84afcc
ToppCellAdult-Epithelial-lung_goblet_cell|Adult / Lineage, Cell type, age group and donor

ARHGEF28 NPAS2

2.31e-031791821fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

RGL3 ITSN1

2.33e-031801827be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell10x5'v1-week_17-19-Myeloid_macrophage-stroma-monocytoid_macrophage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

BMP2K ITSN1

2.33e-03180182ba4c1fb55e8f1095bea6968417fefcf5f700926b
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KLC4 KLC1

2.33e-03180182a682a5d55c612709c9ee9fa4289d6f8bef7fe1af
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF40 NPAS2

2.33e-0318018239ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KLC4 EME1

2.36e-031811829275531e896e118cee043ed94fd31a0070d9581c
ToppCellLeuk-UTI-Lymphocyte-T_NK-CD8_Naive|Leuk-UTI / Disease, Lineage and Cell Type

CD248 NPAS2

2.39e-031821823500a826d86beb98980e2b24e074b02e8e2f957e
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD248 NPAS2

2.39e-0318218274dbb706bcaa0f8c922bf3b0424bce5bb27167fa
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod|TCGA-Mesothelium / Sample_Type by Project: Shred V9

KLC4 PHKB

2.39e-03182182bb1f815718397de96682697fcbd6014a992a28f7
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD248 NPAS2

2.39e-03182182be9c312a44868d4ee266a64d066feb8c5bce5687
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

ARHGEF28 NPAS2

2.39e-03182182a035d45fd512bee8dac38eb387dbf39f5a8a1fed
ToppCellE18.5-samps-Mesenchymal-Myofibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

CD248 ITSN1

2.41e-03183182de08f9ea02b7244d5a8788064631d10f06565337
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

ARHGEF28 NPAS2

2.41e-0318318215d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

RGL3 ARHGEF28

2.41e-03183182c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EME1 RGL3

2.41e-03183182269afec240a756eec3bbae5f30ec784281af3433
ToppCellRA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

RGL3 ARHGEF28

2.41e-03183182cae2ee08f985a6f005b4b8e959e465350315156a
ToppCellControl-Epithelial_cells-Airway_goblet|Control / group, cell type (main and fine annotations)

ARHGEF28 NPAS2

2.44e-03184182d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

BMP2K ITSN1

2.46e-031851828207f9eff113eed429e961748c6b17d672a13b33
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D175|Adult / Lineage, Cell type, age group and donor

BMP2K ITSN1

2.46e-03185182ab5704b96f1d368911308797d10c7c52766ab134
ToppCell343B-Fibroblasts-Fibroblast-E|343B / Donor, Lineage, Cell class and subclass (all cells)

CD248 NPAS2

2.49e-0318618259db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD248 NPAS2

2.49e-031861827c1807fca590cdccf7f5734460bac228d33964ca
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGL3 ARHGEF28

2.49e-031861824e94158db52df41d71e67b02b9895a358eebee0f
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|390C / Donor, Lineage, Cell class and subclass (all cells)

KLC4 LRCH4

2.49e-03186182064b6047215597465bb51a8a1547ef5a226552f9
ToppCell343B-Fibroblasts-Fibroblast-E-|343B / Donor, Lineage, Cell class and subclass (all cells)

CD248 NPAS2

2.49e-031861821bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD248 RGL3

2.49e-031861826568358812f0ca4e0161a1a1b29682fbced35c79
ToppCellControl-Lymphocyte-T_NK-CD8_Naive|Control / Disease, Lineage and Cell Type

CD248 NPAS2

2.52e-03187182cf8bebef36e1ec76a22f229e5c073b3a201d1b93
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGL3 ARHGEF28

2.52e-0318718258d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|lymph-node_spleen / Manually curated celltypes from each tissue

BMP2K ITSN1

2.52e-031871823c10b8501226c69d71bcd99dc1c064a3c2154f87
ToppCellILEUM-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ITSN1 HNRNPUL1

2.52e-031871820099def970fbc828756fbf853eca2ce77b8cd342
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BMP2K ITSN1

2.54e-031881823be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ARHGEF28 NPAS2

2.54e-03188182b9c5d573fc5ab0f7f38c55d006f9576634b05462
ToppCell5'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMP2K ARHGEF40

2.57e-03189182aba941ba6ce7702418b3f470bde573d123c4aade
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RGL3 ARHGEF28

2.57e-031891827659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellnormal_Lung-MAST_cells-MAST|normal_Lung / Location, Cell class and cell subclass

BMP2K ARHGEF40

2.57e-03189182fd053209034fca6eaefe0e5ad024ac4548a100c9
ToppCell390C-Myeloid-Macrophage-FABP4+_Macrophage_2|390C / Donor, Lineage, Cell class and subclass (all cells)

TSGA10IP ARHGEF28

2.57e-031891823b5e1a8d5c1e1fa2124f64f212e9c6b8f1b7d7da
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BMP2K ARHGEF40

2.57e-03189182d26af19fd7e0c7eb78a5a3a245ca5229c4e9e847
ToppCellCOVID-19-Heart-Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

BMP2K ITSN1

2.57e-031891822586f4088721c5debec86c2b211b739fd33713eb
ToppCellnormal_Lung-MAST_cells|normal_Lung / Location, Cell class and cell subclass

BMP2K ARHGEF40

2.57e-03189182f09e387dc0626536050cd537dda212471a7267c4
ToppCellCTRL-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

BMP2K PHKB

2.57e-0318918214f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
DrugDicyclomine hydrochloride [67-92-5]; Up 200; 11.6uM; PC3; HG-U133A

BMP2K PHKB ARHGEF40 HNRNPUL1 NPAS2

3.70e-071981851902_UP
DrugAZD 1480

STAT5A STAT5B

3.54e-064182ctd:C545606
Drug2-hydroxy-1-(2-((9-(4-methylcyclohexyl)-9H-pyrido(4',3'-4,5)pyrrolo(2,3-d)pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone

STAT5A STAT5B

8.84e-066182ctd:C000589290
DrugN'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine

STAT5A STAT5B

2.65e-0510182ctd:C524250
Drug2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide

STAT5A STAT5B

2.65e-0510182ctd:C585912
DrugTrapoxin B

LRCH4 STAT5A STAT5B

3.16e-0579183CID000005532
DrugOrganothiophosphates

STAT5A STAT5B

3.23e-0511182ctd:D063086
DrugAC1L1BB2

RGL3 STAT5A STAT5B

3.66e-0583183CID000001361
Drugboron

RGL3 STAT5A STAT5B NUMA1

4.28e-05257184CID005462311
Drugquizartinib

STAT5A STAT5B

4.58e-0513182ctd:C544967
Drugbenzo(a)pyrene-1,6-quinone

STAT5A STAT5B

7.97e-0517182ctd:C030233
Drugbenzo(a)pyrene-3,6-quinone

STAT5A STAT5B

8.96e-0518182ctd:C018003
Drugtriphenylmethane

STAT5A STAT5B

1.23e-0421182CID000010614
DrugAC1L1DKK

RGL3 STAT5A STAT5B

1.30e-04127183CID000002390
DrugBP-1,6-quinone

STAT5A STAT5B

1.35e-0422182CID000018300
Drugtubulin polymerization inhibitor

STAT5A STAT5B NUMA1

1.81e-04142183CID010125800
DrugA19457

STAT5A STAT5B NUMA1

2.09e-04149183CID000004042
DrugHMBA

RGL3 STAT5A NUMA1

2.43e-04157183CID000003616
DrugPCB 28

STAT5A STAT5B

2.53e-0430182CID000023448
DrugMethylene Chloride

STAT5A STAT5B NPAS2

2.72e-04163183ctd:D008752
Drugnorcantharidin

STAT5A STAT5B

3.07e-0433182ctd:C069741
Drugbrequinar

STAT5A STAT5B

3.26e-0434182CID000057030
Drugguanidinoethylmercaptosuccinic acid

STAT5A STAT5B

3.46e-0435182CID000003464
Drugsauchinone

STAT5A STAT5B

3.46e-0435182ctd:C410958
Drugnitroxyl

CD248 RGL3 HNRNPUL1

3.94e-04185183CID000000945
DrugBenoxinate hydrochloride [5987-82-6]; Down 200; 11.6uM; MCF7; HT_HG-U133A

BMP2K ITSN1 NUMA1

4.26e-041901834115_DN
DrugK-S-L

RGL3 STAT5A

4.30e-0439182CID000484125
DrugN-acetylmethionine

KLC1 NUMA1

4.30e-0439182CID000006180
DrugMethotrexate [59-05-2]; Up 200; 8.8uM; HL60; HG-U133A

BMP2K ITSN1 HNRNPUL1

4.32e-041911832041_UP
DrugBacampicillin hydrochloride [37661-08-8]; Up 200; 8uM; HL60; HT_HG-U133A

ITSN1 STAT5A NUMA1

4.39e-041921831337_UP
DrugAcacetin [480-44-4]; Down 200; 14uM; MCF7; HT_HG-U133A

ITSN1 STAT5B NUMA1

4.39e-041921836044_DN
Drugalpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA

PHKB ITSN1 KLC1

4.46e-041931831048_DN
DrugQuercetine dihydrate [6151-25-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

PHKB ITSN1 STAT5B

4.46e-041931834846_DN
DrugMuramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A

KLC2 HNRNPUL1 NUMA1

4.46e-041931833262_UP
DrugAcetopromazine maleate salt [3598-37-6]; Down 200; 9uM; MCF7; HT_HG-U133A

PHKB STAT5B NUMA1

4.52e-041941836832_DN
DrugW-13, hydrochloride; Up 200; 10uM; MCF7; HG-U133A

ITSN1 STAT5A NUMA1

4.52e-04194183440_UP
DrugIl 10

RGL3 STAT5B

4.52e-0440182CID000146070
DrugNaringenine [480-41-1]; Up 200; 14.6uM; MCF7; HT_HG-U133A

ITSN1 HNRNPUL1 NUMA1

4.59e-041951833278_UP
DrugTrioxsalen [3902-71-4]; Down 200; 17.6uM; PC3; HT_HG-U133A

BMP2K ARHGEF28 NPAS2

4.59e-041951835736_DN
DrugAmoxapine [14028-44-5]; Down 200; 12.8uM; MCF7; HT_HG-U133A

KLC2 STAT5B NUMA1

4.59e-041951834996_DN
DrugCinoxacin [28657-80-9]; Down 200; 15.2uM; PC3; HT_HG-U133A

KLC2 BMP2K NPAS2

4.59e-041951835783_DN
DrugNiacin [59-67-6]; Up 200; 32.4uM; MCF7; HT_HG-U133A

PHKB ITSN1 STAT5B

4.66e-041961835301_UP
Drug6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; HL60; HT_HG-U133A

BMP2K KLC1 STAT5B

4.66e-041961832511_DN
DrugTolazamide [1156-19-0]; Down 200; 12.8uM; HL60; HT_HG-U133A

BMP2K STAT5B NUMA1

4.66e-041961832482_DN
DrugNorethynodrel [68-23-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A

KLC2 BMP2K ITSN1

4.66e-041961831696_DN
DrugSulfamethoxypyridazine [80-35-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A

BMP2K NUMA1 NPAS2

4.66e-041961833409_UP
DrugTrimetazidine dihydrochloride [13171-25-0]; Up 200; 11.8uM; MCF7; HT_HG-U133A

ARHGEF40 ARHGEF28 NUMA1

4.66e-041961832876_UP
DrugButirosin disulfate salt [51022-98-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A

CD248 STAT5B ARHGEF28

4.73e-041971836779_UP
DrugRiboflavine [83-88-5]; Up 200; 10.6uM; HL60; HG-U133A

BMP2K KLC1 HNRNPUL1

4.73e-041971831767_UP
DrugHydrastine hydrochloride [5936-28-7]; Up 200; 9.6uM; MCF7; HT_HG-U133A

CD248 ARHGEF28 NUMA1

4.73e-041971832889_UP
DrugMycophenolic acid [24280-93-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A

BMP2K ITSN1 KLC1

4.73e-041971834137_DN
DrugNoscapine [128-62-1]; Down 200; 9.6uM; PC3; HT_HG-U133A

BMP2K ITSN1 ARHGEF28

4.73e-041971835851_DN
DrugMeclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A

KLC2 BMP2K NUMA1

4.73e-041971835244_DN
DrugEthamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A

ITSN1 STAT5B NUMA1

4.73e-041971837335_DN
DrugCyclacillin [3485-14-1]; Down 200; 11.8uM; PC3; HT_HG-U133A

KLC2 ARHGEF40 ARHGEF28

4.73e-041971833800_DN
DrugCinoxacin [28657-80-9]; Down 200; 15.2uM; MCF7; HT_HG-U133A

KLC2 BMP2K STAT5B

4.73e-041971836257_DN
DrugLymecycline [992-21-2]; Down 200; 6.6uM; MCF7; HT_HG-U133A

BMP2K PHKB STAT5B

4.73e-041971833514_DN
DrugPimozide [2062-78-4]; Down 200; 8.6uM; PC3; HT_HG-U133A

ITSN1 ARHGEF28 NPAS2

4.73e-041971837132_DN
DrugIopromide [73334-07-3]; Up 200; 5uM; MCF7; HT_HG-U133A

BMP2K ITSN1 NUMA1

4.73e-041971836842_UP
DrugBenzthiazide [91-33-8]; Up 200; 9.2uM; MCF7; HT_HG-U133A

CD248 ITSN1 ARHGEF28

4.80e-041981833329_UP
DrugLoracarbef [121961-22-6]; Up 200; 10.8uM; MCF7; HT_HG-U133A

CD248 STAT5B NPAS2

4.80e-041981835492_UP
Drug(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A

BMP2K ITSN1 STAT5B

4.80e-041981834367_DN
DrugTolnaftate [2398-96-1]; Down 200; 13uM; PC3; HG-U133A

KLC2 ARHGEF28 HNRNPUL1

4.80e-041981831919_DN
DrugAltretamine [654-05-6]; Down 200; 19uM; MCF7; HT_HG-U133A

BMP2K STAT5B NUMA1

4.80e-041981835688_DN
DrugTyloxapol [25301-02-4]; Down 200; 4uM; MCF7; HT_HG-U133A

PHKB KLC1 STAT5B

4.80e-041981836452_DN
DrugIsoxicam [34552-84-6]; Down 200; 12uM; MCF7; HT_HG-U133A

ITSN1 STAT5B NUMA1

4.80e-041981837028_DN
DrugZimelidine dihydrochloride monohydrate [61129-30-4]; Down 200; 9.8uM; PC3; HT_HG-U133A

BMP2K NUMA1 NPAS2

4.80e-041981834609_DN
DrugDicumarol [66-76-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A

BMP2K ITSN1 STAT5B

4.80e-041981833423_DN
DrugIsoxsuprine hydrochloride [579-56-6]; Up 200; 11.8uM; HL60; HG-U133A

ITSN1 ARHGEF40 HNRNPUL1

4.80e-041981831985_UP
DrugFlumethasone [2135-17-3]; Down 200; 9.8uM; MCF7; HT_HG-U133A

BMP2K ITSN1 STAT5B

4.87e-041991833410_DN
DrugThioproperazine dimesylate [2347-80-0]; Down 200; 6.2uM; MCF7; HT_HG-U133A

KLC2 BMP2K PHKB

4.87e-041991836265_DN
DrugIopanoic acid [96-83-3]; Up 200; 7uM; MCF7; HT_HG-U133A

BMP2K ARHGEF40 ARHGEF28

4.87e-041991835448_UP
DrugChenodiol [474-25-9]; Down 200; 10.2uM; HL60; HT_HG-U133A

BMP2K ITSN1 KLC1

4.87e-041991832402_DN
Drugchlorpromazine hydrochloride; Down 200; 1uM; HL60; HT_HG-U133A

STAT5A STAT5B NUMA1

4.94e-042001832677_DN
DrugTalampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; HL60; HT_HG-U133A

BMP2K ITSN1 STAT5B

4.94e-042001832954_DN
Drugalpha-estradiol; Down 200; 0.01uM; HL60; HT_HG-U133A

ITSN1 STAT5A STAT5B

4.94e-042001832670_DN
DrugDebrisoquin sulfate [581-88-4]; Down 200; 9uM; PC3; HT_HG-U133A

KLC2 ARHGEF28 NUMA1

4.94e-042001836688_DN
DrugPromazine hydrochloride [53-60-1]; Up 200; 12.4uM; MCF7; HT_HG-U133A

ARHGEF40 STAT5A ARHGEF28

4.94e-042001833927_UP
DrugDimaprit dihydrochloride [23256-33-9]; Up 200; 17uM; MCF7; HT_HG-U133A

BMP2K STAT5B NUMA1

4.94e-042001837480_UP
Drugphosphotyrosine (pY

RGL3 STAT5A STAT5B

5.16e-04203183CID000030819
DrugGp55

RGL3 STAT5A

5.48e-0444182CID003003000
Drug2,4-diacetylphloroglucinol

BMP2K KLC1

5.48e-0444182CID000016547
Drugtheaflavin

RGL3 STAT5A STAT5B

6.87e-04224183CID000114777
DrugMEHP

STAT5A STAT5B

7.07e-0450182CID000020393
DrugHT-2 toxin

RGL3 STAT5A

7.36e-0451182CID000073050
DiseaseAlzheimer's disease 1 (implicated_via_orthology)

KLC4 KLC2 KLC1

5.55e-097173DOID:0080348 (implicated_via_orthology)
Diseasecolon adenocarcinoma (is_implicated_in)

STAT5A STAT5B

1.01e-0426172DOID:234 (is_implicated_in)
Diseasegastric adenocarcinoma (is_marker_for)

STAT5A STAT5B

1.17e-0428172DOID:3717 (is_marker_for)
DiseaseCombined immunodeficiency

STAT5A STAT5B

2.53e-0441172C0494261
DiseaseAcute Promyelocytic Leukemia

STAT5B NUMA1

3.19e-0446172C0023487
DiseaseC-X-C motif chemokine 10 measurement

BMP2K ARHGEF28

1.77e-03109172EFO_0008056
Diseasebreast carcinoma

CD248 TSGA10IP KLC1 ARHGEF28

2.35e-031019174EFO_0000305
Diseaseurinary albumin to creatinine ratio

HNRNPUL1 NUMA1

4.69e-03179172EFO_0007778
Diseaseapolipoprotein A 1 measurement

CD248 ARHGEF28 HNRNPUL1

1.19e-02848173EFO_0004614
Diseasered blood cell density measurement

BMP2K ITSN1 ARHGEF40

1.32e-02880173EFO_0007978
Diseasetelomere length

ARHGEF28 NPAS2

1.37e-02313172EFO_0004505
Diseaseurate measurement

CD248 TSGA10IP KLC1

1.38e-02895173EFO_0004531

Protein segments in the cluster

PeptideGeneStartEntry
EQRQCLRRLQQVLQW

ARHGEF40

781

Q8TER5
RLLWIGLQRQARQCQ

CD248

81

Q9HCU0
RVLQQLQQGDWRLQQ

BMP2K

436

Q9NSY1
DTLQLWQERERRQQQ

LRCH4

406

O75427
QRTRILQANIRWQQE

NPAS2

511

Q99743
QLQQEQRRWLRRCEQ

ARHGEF28

1446

Q8N1W1
RAQVRRLCQENQWLR

KLC4

106

Q9NSK0
WEILARIQQLQRRCQ

RGL3

456

Q3MIN7
RAQVRRLVQENQWLR

KLC2

96

Q9H0B6
QLEWERNRRQELLNQ

ITSN1

446

Q15811
RGLALVWRRQIQQLN

EME1

476

Q96AY2
VWRRQIQQLNRVSLE

EME1

481

Q96AY2
LRAQVRRLCQENQWL

KLC1

106

Q07866
QPQQNGRCWLNRRQI

PHKB

916

Q93100
DWNRIAELQQRNRVC

NUMA1

1916

Q14980
RWDVLIQQATQCLNR

HNRNPUL1

476

Q9BUJ2
LLQAWERQRQEERQQ

TSGA10IP

386

Q3SY00
IWQNRQQIRRAEHLC

STAT5B

286

P51692
IWQNRQQIRRAEHLC

STAT5A

286

P42229