Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransition metal ion binding

ADAMTS15 ZNF195 KMT2A CPD TNKS HDAC6 PPEF2 MSMO1 ADAMTS1 TET1

2.52e-0511893510GO:0046914
GeneOntologyMolecularFunctionzinc ion binding

ADAMTS15 ZNF195 KMT2A CPD TNKS HDAC6 ADAMTS1 TET1

1.22e-04891358GO:0008270
GeneOntologyMolecularFunctionmetallopeptidase activity

ADAMTS15 CPD ADAMTS1 ADAMTS6

4.01e-04200354GO:0008237
GeneOntologyMolecularFunctionmisfolded protein binding

HDAC6 CLU

4.49e-0418352GO:0051787
GeneOntologyMolecularFunctiondynein complex binding

GPSM2 HDAC6

1.10e-0328352GO:0070840
GeneOntologyMolecularFunctionNAD+-protein poly-ADP-ribosyltransferase activity

TNKS TNKS2

1.10e-0328352GO:0003950
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS15 ADAMTS1 ADAMTS6

1.20e-03120353GO:0004222
GeneOntologyMolecularFunctionNAD+-protein ADP-ribosyltransferase activity

TNKS TNKS2

1.26e-0330352GO:1990404
GeneOntologyMolecularFunctioncarboxy-lyase activity

GAD1 ME3

1.81e-0336352GO:0016831
GeneOntologyMolecularFunctionnucleotidyltransferase activity

TNKS TNKS2 GMPPB

2.37e-03152353GO:0016779
GeneOntologyMolecularFunctiontau protein binding

HDAC6 CLU

2.94e-0346352GO:0048156
GeneOntologyMolecularFunctioniron ion binding

PPEF2 MSMO1 TET1

3.04e-03166353GO:0005506
GeneOntologyMolecularFunctionHsp90 protein binding

HDAC6 PPEF2

4.18e-0355352GO:0051879
GeneOntologyMolecularFunctionpentosyltransferase activity

TNKS TNKS2

4.33e-0356352GO:0016763
GeneOntologyMolecularFunctioncarbon-carbon lyase activity

GAD1 ME3

4.33e-0356352GO:0016830
GeneOntologyCellularComponentGABA-ergic synapse

CNTNAP4 GAD1 OGT CLSTN1

1.41e-04164344GO:0098982
GeneOntologyCellularComponenthistone deacetylase complex

OGT HDAC6 TET1

3.54e-0485343GO:0000118
GeneOntologyCellularComponentSin3-type complex

OGT TET1

5.81e-0422342GO:0070822
GeneOntologyCellularComponentpericentriolar material

TNKS TNKS2

9.45e-0428342GO:0000242
GeneOntologyCellularComponentaggresome

HDAC6 CLU

1.93e-0340342GO:0016235
GeneOntologyCellularComponentmitotic spindle pole

GPSM2 TNKS

2.22e-0343342GO:0097431
DomainADAM_spacer1

ADAMTS15 ADAMTS1 ADAMTS6

9.52e-0623343IPR010294
DomainADAM_spacer1

ADAMTS15 ADAMTS1 ADAMTS6

9.52e-0623343PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS15 ADAMTS1 ADAMTS6

1.09e-0524343IPR013273
DomainPeptidase_M12B_N

ADAMTS15 ADAMTS1 ADAMTS6

4.82e-0539343IPR002870
DomainPep_M12B_propep

ADAMTS15 ADAMTS1 ADAMTS6

4.82e-0539343PF01562
DomainDISINTEGRIN_1

ADAMTS15 ADAMTS1 ADAMTS6

5.20e-0540343PS00427
DomainADAM_MEPRO

ADAMTS15 ADAMTS1 ADAMTS6

5.20e-0540343PS50215
DomainDISINTEGRIN_2

ADAMTS15 ADAMTS1 ADAMTS6

5.20e-0540343PS50214
DomainReprolysin

ADAMTS15 ADAMTS1 ADAMTS6

5.20e-0540343PF01421
DomainPeptidase_M12B

ADAMTS15 ADAMTS1 ADAMTS6

5.20e-0540343IPR001590
DomainDisintegrin_dom

ADAMTS15 ADAMTS1 ADAMTS6

5.60e-0541343IPR001762
Domainzf-CXXC

KMT2A TET1

1.75e-0411342PF02008
DomainZnf_CXXC

KMT2A TET1

1.75e-0411342IPR002857
DomainZF_CXXC

KMT2A TET1

1.75e-0411342PS51058
DomainTSP_1

ADAMTS15 ADAMTS1 ADAMTS6

2.03e-0463343PF00090
DomainTSP1

ADAMTS15 ADAMTS1 ADAMTS6

2.23e-0465343SM00209
DomainTSP1_rpt

ADAMTS15 ADAMTS1 ADAMTS6

2.23e-0465343IPR000884
DomainTSP1

ADAMTS15 ADAMTS1 ADAMTS6

2.23e-0465343PS50092
DomainMetalloPept_cat_dom

ADAMTS15 ADAMTS1 ADAMTS6

4.27e-0481343IPR024079
Domain-

ADAMTS15 ADAMTS1 ADAMTS6

4.27e-04813433.40.390.10
DomainPoly(ADP-ribose)pol_cat_dom

TNKS TNKS2

4.30e-0417342IPR012317
DomainPARP_CATALYTIC

TNKS TNKS2

4.30e-0417342PS51059
DomainPARP

TNKS TNKS2

4.30e-0417342PF00644
Domain-

TNKS TNKS2

4.30e-04173423.90.228.10
DomainZINC_PROTEASE

ADAMTS15 ADAMTS1 ADAMTS6

7.45e-0498343PS00142
DomainWGR_domain

TNKS TNKS2

8.66e-0424342IPR008893
DomainADAM_Cys-rich

ADAMTS15 ADAMTS1

1.10e-0327342IPR006586
DomainACR

ADAMTS15 ADAMTS1

1.10e-0327342SM00608
DomainSAM_2

TNKS TNKS2

2.77e-0343342PF07647
DomainTPR_8

GPSM2 OGT

4.18e-0353342PF13181
DomainAnk_2

TNKS TNKS2 GLS

6.92e-03215343PF12796
DomainAnk

TNKS TNKS2 GLS

8.13e-03228343PF00023
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS15 ADAMTS1 ADAMTS6

5.47e-0539273M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS15 ADAMTS1 ADAMTS6

5.47e-0539273MM15165
PathwayWP_GABA_METABOLISM_AKA_GHB

GAD1 GLS

1.92e-0411272M42550
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS15 ADAMTS1 ADAMTS6

2.89e-0468273M27303
PathwayWP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL

GAD1 PCDH19 GLS

3.56e-0473273MM16641
PathwayWP_NAD_BIOSYNTHETIC_PATHWAYS

TNKS TNKS2

7.97e-0422272M39704
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS15 ADAMTS1 ADAMTS6

1.15e-03109273MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS15 ADAMTS1 ADAMTS6

1.21e-03111273M27416
PathwayKEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM

GAD1 GLS

1.69e-0332272M17758
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

GPSM2 TNKS OGT HDAC6 TNKS2 ADAMTS1 CLU DROSHA GLS ME3

3.61e-071285351035914814
Pubmed

Genomic breakpoints and clinical features of MLL-TET1 rearrangement in acute leukemias.

KMT2A TET1

9.84e-07235223100278
Pubmed

Tankyrase is necessary for canonical Wnt signaling during kidney development.

TNKS TNKS2

9.84e-07235220549720
Pubmed

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.

TNKS TNKS2

9.84e-07235218612384
Pubmed

Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.

TNKS TNKS2

9.84e-07235215795250
Pubmed

LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).

KMT2A TET1

9.84e-07235212124344
Pubmed

Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy.

TNKS TNKS2

9.84e-07235228723574
Pubmed

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.

TNKS TNKS2

9.84e-07235227494558
Pubmed

Regulation of tankyrase activity by a catalytic domain dimer interface.

TNKS TNKS2

9.84e-07235230055800
Pubmed

Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients.

TNKS TNKS2

9.84e-07235218026951
Pubmed

Structural insights into SAM domain-mediated tankyrase oligomerization.

TNKS TNKS2

9.84e-07235227328430
Pubmed

The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.

KMT2A TET1

9.84e-07235219144982
Pubmed

Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase.

RNF180 ZIC2

9.84e-07235218363970
Pubmed

Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation.

TNKS TNKS2

9.84e-07235229263426
Pubmed

Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells.

OGT TET1

9.84e-07235223729667
Pubmed

Molecular insights on TNKS1/TNKS2 and inhibitor-IWR1 interactions.

TNKS TNKS2

9.84e-07235224291818
Pubmed

Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.

TNKS TNKS2

9.84e-07235224116873
Pubmed

First description of the t(10;11)(q22;q23)/MLL-TET1 translocation in a T-cell lymphoblastic lymphoma, with subsequent lineage switch to acute myelomonocytic myeloid leukemia.

KMT2A TET1

9.84e-07235224323992
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

OGT HDAC6 ADAMTS1 CLU ATXN7L1 DROSHA PCDH19 ZIC2 ARMC6

1.16e-06111635931753913
Pubmed

Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.

TNKS TNKS2

2.95e-06335233361107
Pubmed

Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.

TNKS TNKS2

2.95e-06335232442396
Pubmed

Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.

TNKS TNKS2

2.95e-06335211739745
Pubmed

Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.

TNKS TNKS2

2.95e-06335226246473
Pubmed

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.

TNKS TNKS2

2.95e-06335225939383
Pubmed

TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

KMT2A TET1

2.95e-06335212646957
Pubmed

Tankyrase inhibition aggravates kidney injury in the absence of CD2AP.

TNKS TNKS2

2.95e-06335227441654
Pubmed

Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.

TNKS TNKS2

2.95e-06335233923443
Pubmed

Analysis of Gene Expression Patterns of Epigenetic Enzymes Dnmt3a, Tet1 and Ogt in Murine Chondrogenic Models.

OGT TET1

2.95e-06335234685658
Pubmed

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.

TNKS TNKS2

2.95e-06335211454873
Pubmed

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.

TNKS TNKS2

2.95e-06335221251231
Pubmed

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family.

ADAMTS1 ADAMTS6

2.95e-06335226025392
Pubmed

Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.

TNKS TNKS2

5.90e-06435230260955
Pubmed

PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.

TNKS TNKS2

5.90e-06435238272024
Pubmed

Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).

OGT TET1

5.90e-06435225568311
Pubmed

Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia.

KMT2A TET1

5.90e-06435226791235
Pubmed

E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling.

TNKS TNKS2

5.90e-06435226513298
Pubmed

Expression of prion gene and presence of prion protein during development of mouse molar tooth germ.

CLSTN1 CLU

5.90e-06435221083616
Pubmed

Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).

OGT TET1

5.90e-06435224394411
Pubmed

Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression.

TNKS TNKS2

5.90e-06435236383218
Pubmed

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.

TNKS TNKS2

5.90e-06435211278563
Pubmed

Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.

OGT TET1

5.90e-06435223352454
Pubmed

Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing.

KMT2A DROSHA

5.90e-06435217581865
Pubmed

The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).

TNKS TNKS2

5.90e-06435211854288
Pubmed

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure.

ADAMTS15 ADAMTS6

9.82e-06535229625437
Pubmed

Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).

TNKS TNKS2

9.82e-06535211802774
Pubmed

Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.

TNKS TNKS2

9.82e-06535235362478
Pubmed

The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.

TNKS TNKS2

9.82e-06535222473005
Pubmed

PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands.

OGT TET1

9.82e-06535234667079
Pubmed

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

TNKS TNKS2

1.47e-05635219759537
Pubmed

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.

TNKS TNKS2

1.47e-05635221799911
Pubmed

Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.

TNKS TNKS2

1.47e-05635226845027
Pubmed

TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator.

OGT TET1

1.47e-05635225517638
Pubmed

DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.

GAD1 TET1

1.47e-05635225476119
Pubmed

Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.

TNKS TNKS2

1.47e-05635234128958
Pubmed

Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.

TNKS TNKS2

1.47e-05635210988299
Pubmed

The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.

ADAMTS15 ADAMTS1

2.06e-05735215599946
Pubmed

Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.

TNKS TNKS2

2.06e-05735222153076
Pubmed

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.

TNKS TNKS2

2.06e-05735225547115
Pubmed

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling.

TNKS TNKS2

2.06e-05735231554794
Pubmed

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.

TNKS TNKS2

2.06e-05735221478859
Pubmed

Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion.

ADAMTS15 ADAMTS1

2.74e-05835223233679
Pubmed

Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis.

TNKS TNKS2

3.53e-05935219766477
Pubmed

Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.

TNKS TNKS2

3.53e-05935212080061
Pubmed

Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes.

KMT2A OGT

4.40e-051035224244196
Pubmed

DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

KMT2A TET1

4.40e-051035229276034
Pubmed

Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data.

GAD1 GLS

4.40e-051035220659789
Pubmed

Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.

ADAMTS15 ADAMTS1

5.38e-051135229337306
Pubmed

Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study.

TNKS TNKS2

5.38e-051135220937264
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF462 OGT FAM193A GLS TET1

5.91e-0541835534709266
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS15 ADAMTS1 ADAMTS6

6.00e-057535320637190
Pubmed

Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons.

GLS ZIC2

6.45e-051235224695699
Pubmed

Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.

TNKS TNKS2

8.89e-051435235733260
Pubmed

Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression.

GAD1 ZIC2

8.89e-051435217360405
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

CNTNAP4 CLSTN1 PCDH19

1.07e-049135328558017
Pubmed

High-throughput RNAi screening reveals novel regulators of telomerase.

TNKS TNKS2

1.17e-041635221531765
Pubmed

Family-wide analysis of poly(ADP-ribose) polymerase activity.

TNKS TNKS2

1.17e-041635225043379
Pubmed

USP25 regulates Wnt signaling by controlling the stability of tankyrases.

TNKS TNKS2

1.17e-041635228619731
Pubmed

Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages.

CNTNAP4 GAD1

1.33e-041735226389685
Pubmed

Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice.

GAD1 ZIC2

1.33e-041735222578469
Pubmed

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.

ADAMTS1 ADAMTS6

1.33e-041735210464288
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

HDAC6 CLSTN1 GLS

1.41e-0410035310048485
Pubmed

Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.

OGT TET1

1.66e-041935222984288
Pubmed

Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.

OGT TET1

1.66e-041935228554894
Pubmed

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

ADAMTS15 ADAMTS1

1.85e-042035219922873
Pubmed

A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.

ZNF462 ME3

2.04e-042135224025145
Pubmed

Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.

GAD1 ZIC2

2.24e-042235218448648
Pubmed

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.

TNKS TNKS2

2.24e-042235227521426
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

TNKS TNKS2 CLU

2.42e-0412035331413325
Pubmed

Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors.

GAD1 ZIC2

2.91e-042535217507568
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

CNTNAP4 CLSTN1 ATXN7L1

3.06e-0413035312421765
Pubmed

Onecut1 and Onecut2 play critical roles in the development of the mouse retina.

GAD1 CLU

3.40e-042735225313862
Pubmed

Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.

GAD1 TET1

3.93e-042935232123907
Pubmed

Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.

GAD1 ZIC2

3.93e-042935229874580
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF462 KMT2A OGT TET1

4.17e-0435135438297188
Pubmed

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain.

GAD1 GLS

4.20e-043035229972793
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

KMT2A OGT CLSTN1 CLU DROSHA

4.58e-0465035538777146
Pubmed

Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.

ADAMTS15 ADAMTS1

4.79e-043235231434798
Pubmed

The Trim family of genes and the retina: Expression and functional characterization.

GAD1 CLU

5.09e-043335230208054
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

CPD HDAC6 MSMO1 CLSTN1 ADAMTS1 GLS ME3

5.22e-04145135730550785
Pubmed

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.

CNTNAP4 GAD1 MSMO1 CLU

5.40e-0437635424154525
CytobandEnsembl 112 genes in cytogenetic band chr5q12

RNF180 ADAMTS6

1.17e-0366352chr5q12
CytobandEnsembl 112 genes in cytogenetic band chr8p21

ESCO2 CLU

4.79e-03135352chr8p21
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS15 ADAMTS1 ADAMTS6

1.72e-061923350
GeneFamilyZinc fingers CXXC-type

KMT2A TET1

1.01e-0412232136
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

TNKS TNKS2

2.08e-0417232684
GeneFamilyAnkyrin repeat domain containing

TNKS TNKS2 GLS

3.44e-03242233403
GeneFamilySterile alpha motif domain containing

TNKS TNKS2

5.54e-0388232760
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

GPSM2 OGT

9.30e-03115232769
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF462 ZNF195 ZNF613 ZIC2

1.20e-0271823428
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000

CPD TNKS OGT FAM193A TNKS2

1.94e-05209345gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000

ADAMTS15 CNTNAP4 CPD TNKS FAM193A TNKS2 RNF180 PCDH19

3.14e-05806348DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000

ADAMTS15 CNTNAP4 CPD TNKS OGT FAM193A TNKS2 ATXN7L1

3.14e-05806348gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#3_top-relative-expression-ranked_1000

ESCO2 ADAMTS15 CNTNAP4 TNKS TET1

1.21e-04307345gudmap_developingKidney_e15.5_Peripheral blastema_1000_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000

CPD TNKS OGT FAM193A TNKS2

1.30e-04312345gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000

ZNF462 CPD TNKS OGT FAM193A TNKS2 RNF180

1.82e-04769347gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000

ZNF462 ADAMTS15 CNTNAP4 RNF180

2.48e-04193344gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000

ZNF462 ADAMTS15 CNTNAP4 CPD OGT TNKS2 RNF180

2.66e-04818347DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000

ZNF462 CNTNAP4 CPD TNKS OGT FAM193A TNKS2

2.66e-04818347gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000

CPD TNKS OGT FAM193A TNKS2

3.45e-04385345gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#5

GAD1 OGT GMPPB PCDH19

4.14e-04221344Facebase_RNAseq_e10.5_Lateral Nasal Eminence_1000_K5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500

ADAMTS15 CNTNAP4 TNKS FAM193A TNKS2

4.44e-04407345gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_100

CNTNAP4 GAD1 CLEC4F

4.84e-0496343Facebase_RNAseq_e10.5_Medial Nasal Eminence_100
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS15 CNTNAP4 GAD1 ME3

7.96e-06163354db6b7ce6f7221bb73c5e650ac51cdd5d7ef00675
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS15 CNTNAP4 GAD1 ME3

8.36e-06165354d8df50f5a3b646e8ea13739fdc65ce6f39b4d4d2
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 GPSM2 ADAMTS1 PCDH19

1.52e-05192354a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

ESCO2 GAD1 GPSM2 PCDH19

1.55e-05193354c2673d86f7d7b849788036032a93a6d136a70040
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GAD1 OGT GLS ME3

1.61e-05195354a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2A GAD1 HDAC6 TNKS2

1.61e-051953543e519cffa6144a62b06124642a14c9ff39b76554
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KMT2A RNF180 CLSTN1 CLU

1.75e-05199354174f6013af6eafa577f84205a62927f2b367fda3
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

CNTNAP4 ADAMTS1 ADAMTS6 CLU

1.78e-0520035465b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS15 CNTNAP4 ADAMTS6

1.61e-0413535354b2aaf8d322e01a3ff6099c2422d68ecccf96b4
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-7|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

KMT2A GPSM2 TET1

1.99e-0414535388090a226ddfa6df59976f025bf0fd84ca0f72ef
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF462 OGT ADAMTS6

2.56e-041583536d2709b387945c015faa223c20d22b52a4082140
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CNTNAP4 GAD1 ADAMTS1

2.61e-04159353c64fff8d89f84d1f5a0cc432e31f56f741162505
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS15 CNTNAP4 GAD1

2.96e-0416635359d47c1fca7a8c70f6998f3367a9dbcb9b67966f
ToppCellDividing_Macrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 GPSM2 ADAMTS6

2.96e-04166353c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS15 CNTNAP4 GAD1

2.96e-04166353b4241f8d2a0aa910dbb0d0d5d3631a9b73453fe9
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS15 CNTNAP4 GAD1

3.07e-041683532572a3dd4f3f619bd26a3cd6e60de43821d8bb64
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC4F RNF180 CLSTN1

3.07e-041683534ae9e9d93bcd6f4d5815e57fd5afa7a3398a0ec1
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC4F RNF180 CLSTN1

3.12e-04169353454b92b9b67299a64278c010db033ca5b9d217a0
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF462 CLEC4F CLU

3.12e-04169353780fb0050852626062a729dd1b82b0cf61e7e9ca
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS1 CLU PCDH19

3.17e-041703531a568efcff9c39b3f709b55a05d24710450a2657
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS1 CLU PCDH19

3.17e-0417035366d41d794790e621d72ac37af995510537103c9c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS1 ADAMTS6

3.17e-0417035336dbbdb13f69307afd2122ff051b2980850c1f00
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_ventral_progenitors|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

ESCO2 GAD1 GPSM2

3.17e-0417035373601c873b177d5d134618d8e228c51381119f7d
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GMPPB CLU ARMC6

3.23e-041713533ad4f138d9570500cfb4423a2be16bb7d1cacbf8
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-like-AT2_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GMPPB CLU ARMC6

3.23e-04171353ca2775a17b5c339c480a963953b6fa2b0731f24d
ToppCell10x_5'_v1-Neoplastic|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CNTNAP4 GAD1 CLEC4F

3.45e-04175353379f595be2273f662064c920d195a30491aa88d6
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4|GI_large-bowel / Manually curated celltypes from each tissue

YTHDF1 ZNF195 ADAMTS6

3.57e-04177353eb87ea93e36a8f97442ec8515f658ee61932dc0f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS1 ADAMTS6

3.57e-0417735384116796ca4c7007508c0f1a68a1135c7b922278
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS6 PCDH19

3.57e-04177353d7976eac7e27044f6a859cc0c3398d08576e8c01
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS1 ADAMTS6 TET1

3.63e-041783530fb36679cddc9ed8f4b5b34e174d5133c2ea1c76
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS1 ADAMTS6

3.63e-041783532a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTS1 CLU ME3

3.63e-04178353ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTS1 CLU ME3

3.63e-0417835387b04753650e45f12299c8456fb980d6c0d5961c
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTS1 CLU ME3

3.63e-04178353ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS6 PCDH19

3.69e-04179353cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
ToppCellPND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 GAD1 CLU

3.69e-04179353362c003503190dc272fa89185a83a65e063d7a67
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS6 PCDH19

3.69e-0417935301302505816f272243659e20d751b61a198a2fc0
ToppCellPND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 GAD1 CLU

3.69e-041793537d2e6bde00a9ab4cb21bd48b140ce205e36f9d77
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

3.69e-0417935397ba67a856680f24846244c0b92c886cc0e79537
ToppCellPND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 GAD1 CLU

3.69e-04179353e0eec8d48868c76c3e879f219357c62ceff1bc76
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS6 PCDH19

3.75e-04180353c6030e725e3d86d5d74a1676330c77ffeceb324f
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS1 ADAMTS6

3.81e-04181353062f00736eed96e4f4327615d093558dd7d82b20
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS1 ADAMTS6

3.81e-041813537846c7b33d1b89364c5a704edaa86520db731c89
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

3.87e-041823537dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS1 ADAMTS6

3.87e-04182353d3a037268f026eb2f84428b1821022503cef7756
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

3.87e-04182353420a8fd30543e37a66ba0786215d056d308660d0
ToppCellE18.5-samps-Mesenchymal-Myofibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

ADAMTS15 GAD1 ADAMTS6

3.94e-04183353de08f9ea02b7244d5a8788064631d10f06565337
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF195 FAM193A CLSTN1

3.94e-04183353807d64deaf4e50dccf6f831f88578a6d903c1421
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GAD1 CLU ZIC2

3.94e-04183353a90ffd9c50caa65f537a2e441e37655e1b622327
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GAD1 OGT GLS

3.94e-041833532f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell3'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS1 ADAMTS6 PCDH19

3.94e-04183353f8212bf8a8b8312434ae030261c558c147f61747
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

3.94e-04183353e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3-6_VIP_KCTD13|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS6 PCDH19

3.94e-04183353f06c06c75aab55fa8c803665afaa399446aec5af
ToppCellControl-T/NK-proliferating_T/NK|Control / Disease group,lineage and cell class （2021.01.30）

ESCO2 ZNF462 GPSM2

3.94e-04183353e740f05536d1e4b2512811771928eb65f6696409
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GAD1 CLU ZIC2

3.94e-0418335313ad20ec140ef5b96fdace3369b5befc0f40bb76
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

3.94e-041833535e361be3ae3fe05098968e58427630127bd12675
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS1 ADAMTS6 PCDH19

3.94e-04183353af8d86f15a549064530d94bd47081daf59d58ecd
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS1 ADAMTS6 PCDH19

3.94e-04183353858682df5592c6856487487a7baabd6e60e63a38
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.06e-0418535316e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KMT2A OGT ADAMTS6

4.06e-04185353f1263899a2d41d182022dc4ca62cbae08a463c89
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.06e-04185353027020754dbf71b0034791f9a34ae795e3b85f81
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS1 ADAMTS6

4.06e-041853530b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.06e-041853534c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.06e-041853533189e91fe26df59bd605d2b6223ceb1779daf0b8
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.06e-0418535308fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.06e-04185353cefd81adb480c027545a5c78dcd05669783717f4
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_RCN1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.06e-04185353538db481c82b02e5d3b8e03b166f754cc936901e
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ZNF195 FAM193A CLSTN1

4.13e-0418635376cbc3610aedf8c19c17ad5faf6ef5e8980b6af5
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 GPSM2 CLEC4F

4.13e-04186353ec6d0c29e196e374baa96dd3d506f489c959e77e
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KMT2A OGT ADAMTS6

4.13e-04186353bbcd9062c0f6f65ca6f3cb101b6fa72ddd1e14fe
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNTNAP4 ADAMTS6 CLU

4.13e-041863532d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS6 CLU ME3

4.13e-0418635392092f11ecce22c14f244e42c499af0822977e6f
ToppCell(2)_Fibroblasts-(20)_Fibro-1|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

ADAMTS15 ADAMTS1 PCDH19

4.13e-04186353e93415b59dd89bc8a966dab0e0b65fe215933598
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 GPSM2 CLEC4F

4.13e-041863533993f1ef8a33b8a75dfd3db8d4845b5afbb0bb3d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.13e-04186353fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS15 ADAMTS1 CLU

4.13e-041863533dae539cce15fcf2b1b32e981d7febe94c03c600
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.19e-04187353ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.19e-0418735302105c82a9ba79d2f19e002188377fc3440770c2
ToppCellControl-Fibroblasts-Adventitial_FB|Control / group, cell type (main and fine annotations)

ADAMTS15 ADAMTS1 CLU

4.26e-04188353706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS1 CLU GLS

4.26e-04188353eadcf90b526be8fe567267da83966c8802608030
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS15 ADAMTS1 CLU

4.33e-041893531ecf9911ff82e0ca0f0c101b735d3b1f3b339d57
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNTNAP4 ADAMTS1 ADAMTS6

4.33e-04189353b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellEndothelial-A-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

ADAMTS1 CLU PCDH19

4.33e-0418935304b565855f58ca0f343904d04be657b66e109076
ToppCellwk_20-22-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

GAD1 CLU ZIC2

4.39e-04190353103e78c2233c3ee0c215a9dafe70705477e9ee5e
ToppCellEndothelial-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ADAMTS1 ADAMTS6 CLU

4.46e-04191353f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP4 GAD1 ADAMTS6

4.46e-04191353764c3a8829ae1253a0790744138266e81fc075ec
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ADAMTS6 PCDH19

4.46e-0419135306760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF462 CNTNAP4 GAD1

4.53e-04192353f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF462 CNTNAP4 GAD1

4.53e-04192353690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCellLPS-IL1RA-Endothelial-Endothelial-Vein|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS1 ADAMTS6 ME3

4.53e-04192353717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

KMT2A OGT GLS

4.53e-0419235347646d7e4990be85072987f92bf18d52f8da752e
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSMO1 CLU ME3

4.60e-04193353b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF462 CNTNAP4 GAD1

4.60e-04193353294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF462 CNTNAP4 GAD1

4.60e-041933533d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF462 CNTNAP4 GAD1

4.67e-041943535d0b0d8e96f0e0297a4dba70a05d87081a4eb323
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF462 CNTNAP4 GAD1

4.67e-041943536ac759828c41ffa974ee82842162caa959351dd1
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS1 CLU ME3

4.67e-04194353e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS1 CLU ME3

4.67e-041943534b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Cajal_Retzius-36|World / Primary Cells by Cluster

CLSTN1 CLU ZIC2

4.74e-04195353bc76a0586cc78f013cb96a2444e63e3c5daa3bc7
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTS15 GPSM2 ADAMTS1

4.74e-04195353ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
Diseasechemotherapy-induced alopecia, response to antimicrotubule agent

ZNF462 ME3

7.04e-0511342EFO_0005260, EFO_0005400
Diseasediabetes mellitus (implicated_via_orthology)

GAD1 OGT

4.12e-0426342DOID:9351 (implicated_via_orthology)
Diseaserespiratory failure, COVID-19

CPD CFAP61

5.13e-0429342EFO_0009686, MONDO_0100096
Diseasecorneal resistance factor

ADAMTS15 KMT2A ADAMTS6 TET1

1.74e-03451344EFO_0010067
DiseaseLiver carcinoma

CNTNAP4 KMT2A ADAMTS1 ZIC2

2.66e-03507344C2239176
Diseasechronotype measurement

ZNF462 CFAP61 FAM193A GLS TET1

3.20e-03882345EFO_0008328
DiseaseSchizophrenia

KMT2A GAD1 CLU TET1 ZIC2

3.21e-03883345C0036341
Diseaselate-onset Alzheimers disease

ZNF462 ADAMTS1 CLU

4.57e-03292343EFO_1001870

Protein segments in the cluster

PeptideGeneStartEntry
QREEHGHMHHFALNP

CFAP61

551

Q8NHU2
FDDDIRVPFGHAHNH

ARMC6

251

Q6NXE6
HRHHFHARGEFNLMN

CNTNAP4

291

Q9C0A0
HANHMAAQPQFVHPE

CLSTN1

821

O94985
QHEPLSFFFDIMQHH

FAM193A

1026

P78312
NKEDMHLFGHYPAHD

ATXN7L1

81

Q9ULK2
HELGHVFNMPHDNVK

ADAMTS15

361

Q8TE58
IAHEIGHNFGMNHDG

ADAMTS6

401

Q9UKP5
HELGHVFNMPHDDAK

ADAMTS1

401

Q9UHI8
NTPMDEALHFGHHDV

GLS

621

O94925
AAFSANERPRHHHAM

MSL3P1

146

P0C860
GSRHHDFHHMNFIGN

MSMO1

246

Q15800
MPDHDQNEGFHCREE

PCDH19

946

Q8TAB3
GNHDQAMHFAEKHLE

GPSM2

336

P81274
PFQAMVQFHRHHGQE

GMPPB

116

Q9Y5P6
FHHPHQLLEGMEGFN

GAD1

141

Q99259
IQPKDFHHHHFPDME

CPD

496

O75976
PEDEMQHVQHHHRFL

ESCO2

401

Q56NI9
HLNHEKEMFAQDHPE

ME3

381

Q16798
PDHFIQGHMDADHIS

KMT2A

2991

Q03164
HHGNGTQHMFEDDPS

HDAC6

651

Q9UBN7
PKEFHLNRGNHEDHM

PPEF2

231

O14830
HTFFIGDHANMFPHL

OGT

701

O15294
PHGAHRMDYLHFEDD

RNF180

541

Q86T96
SHHLNFGMNPDHARN

DROSHA

901

Q9NRR4
GFHNPRMFEQHHPRS

TEX53

21

A0A1B0GU33
DFCAHPHRDIHNMNN

TET1

1666

Q8NFU7
FEPNNHHHFGREAEM

CLEC4F

86

Q8N1N0
QAMDIHFHSPAFQHP

CLU

256

P10909
EENHNHHNERMLFHG

TNKS

1171

O95271
HHNERMLFHGSPFIN

TNKS

1176

O95271
HNHANERMLFHGSPF

TNKS2

1021

Q9H2K2
HAKHEQFHNEMNFPE

ZNF613

166

Q6PF04
GEHHPEAMNVLNFDH

ZNF462

906

Q96JM2
ADGHPEMGFHHATQA

ZNF195

71

O14628
QLSNGDHHFMHDAVF

YTHDF1

91

Q9BYJ9
DHHFMHDAVFGQPGG

YTHDF1

96

Q9BYJ9
HHHHPGAFFRYMRQQ

ZIC2

236

O95409