Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	PPARGC1A KATNAL2 CYFIP1 SPATA31A1 SPATA31A3 SPATA31A7 CAPN6 TRIOBP SPATA31A6 SPATA31A5 NIN	1.71e-04	1099	55	11	GO:0008092
GeneOntologyMolecularFunction	actin binding	CYFIP1 SPATA31A1 SPATA31A3 SPATA31A7 TRIOBP SPATA31A6 SPATA31A5	3.28e-04	479	55	7	GO:0003779
GeneOntologyMolecularFunction	nuclear estrogen receptor binding	DCAF1 PPARGC1A MED1	4.20e-04	53	55	3	GO:0030331
GeneOntologyMolecularFunction	RNA 7-methylguanosine cap binding	CYFIP1 CYFIP2	6.64e-04	14	55	2	GO:0000340
GeneOntologyCellularComponent	acrosomal vesicle	SPATA31A1 SPATA31A3 SPATA31A7 RCBTB2 SPATA31A6 SPATA31A5	2.03e-05	206	57	6	GO:0001669
GeneOntologyCellularComponent	secretory granule	THBS1 CYFIP1 SPATA31A1 SPATA31A3 PDGFB SPATA31A7 SLC30A8 RCBTB2 ITGAX SPATA31A6 SPATA31A5	7.85e-05	1014	57	11	GO:0030141
GeneOntologyCellularComponent	secretory vesicle	THBS1 CYFIP1 SPATA31A1 SPATA31A3 PDGFB SPATA31A7 APBA1 SLC30A8 RCBTB2 ITGAX SPATA31A6 SPATA31A5	1.11e-04	1246	57	12	GO:0099503
GeneOntologyCellularComponent	SCAR complex	CYFIP1 CYFIP2	4.74e-04	12	57	2	GO:0031209
Domain	DUF4599	SPATA31D1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.18e-10	12	53	5	PF15371
Domain	DUF4599	SPATA31D1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.18e-10	12	53	5	IPR027970
Domain	Cytoplasmic_FMR1-int	CYFIP1 CYFIP2	7.90e-06	2	53	2	IPR008081
Domain	FragX_IP	CYFIP1 CYFIP2	7.90e-06	2	53	2	PF05994
Domain	DUF1394	CYFIP1 CYFIP2	4.72e-05	4	53	2	PF07159
Domain	DUF1394	CYFIP1 CYFIP2	4.72e-05	4	53	2	IPR009828
Domain	TSP_1	THBS1 HMCN1 C7	7.60e-04	63	53	3	PF00090
Domain	-	RASA1 DOCK11 APBA1 APBA2 TRIOBP ARHGAP20	8.10e-04	391	53	6	2.30.29.30
Domain	TSP1	THBS1 HMCN1 C7	8.32e-04	65	53	3	SM00209
Domain	TSP1_rpt	THBS1 HMCN1 C7	8.32e-04	65	53	3	IPR000884
Domain	TSP1	THBS1 HMCN1 C7	8.32e-04	65	53	3	PS50092
Domain	PH_dom-like	RASA1 DOCK11 APBA1 APBA2 TRIOBP ARHGAP20	1.26e-03	426	53	6	IPR011993
Domain	VWFA	HMCN1 ITGAX ITIH2	1.63e-03	82	53	3	PS50234
Domain	VWA	HMCN1 ITGAX ITIH2	1.75e-03	84	53	3	SM00327
Domain	EGF_CA	THBS1 HMCN1 C1R	1.87e-03	86	53	3	PF07645
Domain	C2H2_Znf_fam	ZNF518B ZNF518A	2.10e-03	24	53	2	IPR027775
Domain	VWF_A	HMCN1 ITGAX ITIH2	2.79e-03	99	53	3	IPR002035
Domain	PID	APBA1 APBA2	2.85e-03	28	53	2	PF00640
Domain	LisH	DCAF1 KATNAL2	2.85e-03	28	53	2	SM00667
Domain	LisH	DCAF1 KATNAL2	2.85e-03	28	53	2	IPR006594
Domain	LISH	DCAF1 KATNAL2	2.85e-03	28	53	2	PS50896
Domain	PID	APBA1 APBA2	3.71e-03	32	53	2	PS01179
Domain	EGF_3	THBS1 HMCN1 C1R C7	4.42e-03	235	53	4	PS50026
Domain	EGF_CA	THBS1 HMCN1 C1R	5.02e-03	122	53	3	SM00179
Domain	EGF-like_Ca-bd_dom	THBS1 HMCN1 C1R	5.25e-03	124	53	3	IPR001881
Domain	EGF-like_dom	THBS1 HMCN1 C1R C7	5.41e-03	249	53	4	IPR000742
Domain	PTB	APBA1 APBA2	5.75e-03	40	53	2	SM00462
Domain	EGF_1	THBS1 HMCN1 C1R C7	5.88e-03	255	53	4	PS00022
Domain	PTB/PI_dom	APBA1 APBA2	6.04e-03	41	53	2	IPR006020
Domain	C2	RASA1 CAPN6 WWC1	6.12e-03	131	53	3	PF00168
Domain	EGF-like_CS	THBS1 HMCN1 C1R C7	6.38e-03	261	53	4	IPR013032
Domain	EGF_2	THBS1 HMCN1 C1R C7	6.73e-03	265	53	4	PS01186
Domain	C2	RASA1 CAPN6 WWC1	7.64e-03	142	53	3	PS50004
Domain	PH	RASA1 DOCK11 TRIOBP ARHGAP20	7.94e-03	278	53	4	SM00233
Domain	PH_DOMAIN	RASA1 DOCK11 TRIOBP ARHGAP20	8.04e-03	279	53	4	PS50003
Domain	PH_domain	RASA1 DOCK11 TRIOBP ARHGAP20	8.14e-03	280	53	4	IPR001849
Domain	-	RASA1 CAPN6 WWC1	8.55e-03	148	53	3	2.60.40.150
Domain	Sushi	C1R C7	9.57e-03	52	53	2	PF00084
Domain	CCP	C1R C7	1.03e-02	54	53	2	SM00032
Domain	SUSHI	C1R C7	1.10e-02	56	53	2	PS50923
Domain	VWA	ITGAX ITIH2	1.10e-02	56	53	2	PF00092
Domain	C2_dom	RASA1 CAPN6 WWC1	1.13e-02	164	53	3	IPR000008
Pathway	BIOCARTA_CARM_ER_PATHWAY	PPARGC1A HDAC4 MED1	5.26e-05	26	40	3	M2499
Pathway	BIOCARTA_PPARG_PATHWAY	PPARGC1A MED1	1.63e-04	7	40	2	MM1573
Pathway	BIOCARTA_PPARG_PATHWAY	PPARGC1A MED1	2.17e-04	8	40	2	M22058
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	5.92e-14	6	57	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	5.92e-14	6	57	5	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 CYFIP2	1.94e-12	24	57	6	32212159
Pubmed	Abi1 is essential for the formation and activation of a WAVE2 signalling complex.	CYFIP1 CYFIP2 NIN	4.97e-07	10	57	3	15048123
Pubmed	The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.	APBA1 APBA2	2.64e-06	2	57	2	9614075
Pubmed	Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.	CYFIP1 CYFIP2	2.64e-06	2	57	2	38128786
Pubmed	Expression and localization of X11 family proteins in neurons.	APBA1 APBA2	2.64e-06	2	57	2	27268412
Pubmed	C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.	CYFIP1 CYFIP2	2.64e-06	2	57	2	24357318
Pubmed	A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission.	APBA1 APBA2	2.64e-06	2	57	2	12547917
Pubmed	Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system.	APBA1 APBA2	2.64e-06	2	57	2	7678331
Pubmed	The PTB domain: a new protein module implicated in signal transduction.	APBA1 APBA2	2.64e-06	2	57	2	7545337
Pubmed	Interaction of platelet-derived growth factor with thrombospondin 1.	THBS1 PDGFB	2.64e-06	2	57	2	9334164
Pubmed	Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.	CYFIP1 CYFIP2	2.64e-06	2	57	2	34327661
Pubmed	Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.	CYFIP1 CYFIP2	2.64e-06	2	57	2	29752658
Pubmed	Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.	CYFIP1 CYFIP2	2.64e-06	2	57	2	35567753
Pubmed	Comparison of primary structure of a neuron-specific protein, X11, between human and mouse.	APBA1 APBA2	2.64e-06	2	57	2	7719031
Pubmed	Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.	CYFIP1 CYFIP2	2.64e-06	2	57	2	31324746
Pubmed	X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors.	APBA1 APBA2	2.64e-06	2	57	2	30411795
Pubmed	Meta-analysis of genome-wide association studies for personality.	KATNAL2 RASA1	7.91e-06	3	57	2	21173776
Pubmed	Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein.	APBA1 APBA2	7.91e-06	3	57	2	14970211
Pubmed	Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1α and MED1 complex.	PPARGC1A MED1	7.91e-06	3	57	2	24458359
Pubmed	RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing.	APBA1 APBA2	7.91e-06	3	57	2	15699037
Pubmed	A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function.	APBA1 APBA2	1.58e-05	4	57	2	30988517
Pubmed	Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.	APBA1 APBA2	1.58e-05	4	57	2	17167098
Pubmed	X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains.	APBA1 APBA2	1.58e-05	4	57	2	11083918
Pubmed	Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein.	APBA1 APBA2	1.58e-05	4	57	2	9585438
Pubmed	Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.	APBA1 APBA2	1.58e-05	4	57	2	19118172
Pubmed	Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.	CYFIP1 CYFIP2	1.58e-05	4	57	2	15294869
Pubmed	X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.	APBA1 APBA2	1.58e-05	4	57	2	18845544
Pubmed	Novel mediators of amyloid precursor protein signaling.	APBA1 APBA2	1.58e-05	4	57	2	20016085
Pubmed	Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.	CYFIP1 CYFIP2	1.58e-05	4	57	2	27605705
Pubmed	Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generation.	APBA1 APBA2	1.58e-05	4	57	2	24742670
Pubmed	Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.	CYFIP1 CYFIP2	1.58e-05	4	57	2	20228810
Pubmed	Mints as adaptors. Direct binding to neurexins and recruitment of munc18.	APBA1 APBA2	1.58e-05	4	57	2	11036064
Pubmed	Recurrent activating mutations of PPARγ associated with luminal bladder tumors.	PPARGC1A MED1	1.58e-05	4	57	2	30651555
Pubmed	Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein.	APBA1 APBA2	2.63e-05	5	57	2	12842896
Pubmed	A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes.	PPARGC1A MED1	2.63e-05	5	57	2	15026545
Pubmed	Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting.	APBA1 APBA2	2.63e-05	5	57	2	9822620
Pubmed	Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.	APBA1 APBA2	2.63e-05	5	57	2	15563604
Pubmed	Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance.	PPARGC1A MED1	2.63e-05	5	57	2	17011503
Pubmed	Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.	APBA1 APBA2	2.63e-05	5	57	2	9395480
Pubmed	Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.	PPARGC1A MED1	2.63e-05	5	57	2	22070604
Pubmed	RUNX1 and TGF-β signaling cross talk regulates Ca2+ ion channels expression and activity during megakaryocyte development.	THBS1 PDGFB ACVR1	2.63e-05	35	57	3	32281291
Pubmed	The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.	PPARGC1A MED1	3.94e-05	6	57	2	17468099
Pubmed	Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene.	PPARGC1A MED1	3.94e-05	6	57	2	19782026
Pubmed	A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.	CYFIP1 CYFIP2	3.94e-05	6	57	2	11438699
Pubmed	Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms.	APBA1 APBA2	3.94e-05	6	57	2	12196555
Pubmed	Amino acids important for ligand specificity of the human constitutive androstane receptor.	PPARGC1A MED1	3.94e-05	6	57	2	15572376
Pubmed	Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.	HDAC4 UBA2	3.94e-05	6	57	2	11451954
Pubmed	Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus.	CYFIP1 CYFIP2	3.94e-05	6	57	2	31853374
Pubmed	Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2.	APBA1 APBA2	3.94e-05	6	57	2	38072052
Pubmed	Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null Embryonic Mice.	CYFIP1 CYFIP2	5.51e-05	7	57	2	30687000
Pubmed	S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects.	PPARGC1A MED1	5.51e-05	7	57	2	17704298
Pubmed	Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.	HDAC4 IFI16	7.34e-05	8	57	2	24413532
Pubmed	Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.	PPARGC1A MED1	7.34e-05	8	57	2	23178929
Pubmed	Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.	PPARGC1A MED1	9.43e-05	9	57	2	14636573
Pubmed	Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton.	CYFIP1 CYFIP2	9.43e-05	9	57	2	38981622
Pubmed	Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.	PPARGC1A MED1	1.18e-04	10	57	2	30595551
Pubmed	Ubc9 sumoylation regulates SUMO target discrimination.	HDAC4 UBA2	1.18e-04	10	57	2	18691969
Pubmed	Endothelial Restoration of Receptor Activity-Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated Cardiomyopathy.	PPARGC1A CASR	1.44e-04	11	57	2	27402918
Pubmed	Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.	PPARGC1A MED1	1.44e-04	11	57	2	15681609
Pubmed	Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.	ZNF518B ZNF518A EZHIP	1.55e-04	63	57	3	25680957
Pubmed	Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.	PPARGC1A MED1	1.72e-04	12	57	2	12189208
Pubmed	Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.	APBA1 APBA2	1.72e-04	12	57	2	10846156
Pubmed	Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity.	CYFIP1 CYFIP2	2.03e-04	13	57	2	34508581
Pubmed	Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues.	PPARGC1A MED1	2.03e-04	13	57	2	33888560
Pubmed	Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human.	PDGFB TRIOBP	2.37e-04	14	57	2	10384052
Pubmed	MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.	AFF3 DOT1L	2.37e-04	14	57	2	20854876
Pubmed	Selection system for genes encoding nuclear-targeted proteins.	UBA2 TRIOBP	2.37e-04	14	57	2	9853615
Pubmed	Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".	SPATA22 GOLGA3	3.12e-04	16	57	2	29878059
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DCAF1 THBS1 TTC17 MED1	3.43e-04	202	57	4	33005030
Pubmed	Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.	PPARGC1A MED1	3.53e-04	17	57	2	28291835
Pubmed	In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.	CYFIP1 CYFIP2	3.97e-04	18	57	2	9463375
Pubmed	Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.	PPARGC1A ZNF350 MED1	4.29e-04	89	57	3	18950845
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	RBM33 AFF3 ZNF518B ZNF518A	4.90e-04	222	57	4	37071664
Pubmed	Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.	THBS1 CYFIP1 TRIOBP IFI16	5.41e-04	228	57	4	30471916
Pubmed	Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.	PPARGC1A MED1	5.43e-04	21	57	2	19596656
Pubmed	NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.	CYFIP1 CYFIP2	5.97e-04	22	57	2	21946561
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	HDAC4 DOCK11 WWC1 CYFIP2 NIN	8.21e-04	446	57	5	24255178
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	THBS1 C1R C7 ITIH2	8.46e-04	257	57	4	16335952
Pubmed	Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism.	PPARGC1A SLC30A8	9.02e-04	27	57	2	20384434
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CYFIP1 HDAC4 DOCK11 TRIOBP UNC79 GOLGA3 CYFIP2	9.67e-04	963	57	7	28671696
Pubmed	Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.	PPARGC1A MED1	9.71e-04	28	57	2	28159809
Pubmed	Spermatogonia-dependent expression of testicular genes in mice.	C7 ITIH2	1.04e-03	29	57	2	12051830
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	CYFIP1 RBM33 PREP UBA2 MED1	1.06e-03	472	57	5	38943005
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	DCAF1 TTC17 GOLGA3 NIN	1.24e-03	285	57	4	32838362
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CYFIP1 DOCK11 RBM33 RRP8 SPATA31A6	1.33e-03	497	57	5	36774506
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	CYFIP1 RBM33 TTC17 MED1 CYFIP2	1.44e-03	506	57	5	30890647
Pubmed	DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.	RBM33 DNAH6	1.52e-03	35	57	2	24515614
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	CYFIP1 PREP TTC17 ITIH2	1.57e-03	304	57	4	32235678
Interaction	FXR1 interactions	CYFIP1 HDAC4 TRIOBP RCBTB2 RRP8 DOT1L IFI16 RPA4 GOLGA3 CYFIP2	9.28e-06	679	53	10	int:FXR1
Interaction	TCERG1 interactions	CYFIP1 HDAC4 UBA2 DOT1L RPA4 CYFIP2	1.68e-05	207	53	6	int:TCERG1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	4.22e-05	8	57	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	4.11e-04	24	57	2	9p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	SPATA31D1 SPATA31A3 APBA1	1.98e-03	199	57	3	chr9q21
GeneFamily	Complement system\|Sushi domain containing	C1R C7 ITGAX	5.38e-05	36	37	3	492
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	C1R C7	6.06e-03	57	37	2	1179
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASA1 DOCK11 TRIOBP	8.52e-03	206	37	3	682
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 TFCP2L1 HMCN1 CASR CYFIP2	1.06e-07	184	55	6	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	Kidney-Tubules\|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.	PPARGC1A THBS1 TFCP2L1 CASR WWC1 CYFIP2	1.73e-07	200	55	6	0726456906e078244a9cff35aee8c5bce4566fb1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 TFCP2L1 CASR CYFIP2	3.11e-06	183	55	5	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 TFCP2L1 CASR CYFIP2	3.28e-06	185	55	5	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 TFCP2L1 CASR CYFIP2	3.46e-06	187	55	5	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 TFCP2L1 CASR CYFIP2	3.73e-06	190	55	5	3dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR WWC1 CYFIP2	4.03e-06	193	55	5	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR WWC1 CYFIP2	4.24e-06	195	55	5	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 AFF3 APBA2 IFI16 ITGAX	4.24e-06	195	55	5	7b6c69df943842b566a596e30bb50dbe80dccc83
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	THBS1 HMCN1 C1R C7 ARHGAP20	4.57e-06	198	55	5	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	HMCN1 PDGFB ZNF518B IFI16 NIN	4.79e-06	200	55	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Kidney\|World / Skin and Kidney Cells in Lupus Nephritis Patients.	PPARGC1A THBS1 CASR C7 CYFIP2	4.79e-06	200	55	5	1f99afa1f3c32a2a9cfb4ad33ff4d404e34fac63
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 CASR CYFIP2	4.56e-05	160	55	4	03b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A CAPN6 DNAH6 CYFIP2	4.90e-05	163	55	4	cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 CASR CYFIP2	6.04e-05	172	55	4	1565f38266891c3acf49778838de134c5dee5460
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBS1 CAPN6 C1R C7	6.75e-05	177	55	4	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A HMCN1 CASR CYFIP2	6.90e-05	178	55	4	4df6218b20c2f076c22346d23260964cc0d73e65
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KATNAL2 CASR CYFIP2	7.21e-05	180	55	4	0b653b1b653b40f3b8711d1312029a4a8a4961db
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 HMCN1 CASR DNAH6	7.52e-05	182	55	4	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMCN1 CAPN6 C1R C7	7.52e-05	182	55	4	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 CASR CYFIP2	7.52e-05	182	55	4	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPARGC1A TFCP2L1 CASR WWC1	7.52e-05	182	55	4	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 APBA1 ARHGAP20 ITGAX	7.85e-05	184	55	4	4f4aeef3b821a003e857fe4a195124d44b2d7479
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN6 C1R C7 ARHGAP20	7.85e-05	184	55	4	4d4d8f3f44c67d74c57e7af7b7c158f0157b2f49
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBS1 GPR75 C1R C7	8.01e-05	185	55	4	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 CASR CYFIP2	8.01e-05	185	55	4	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 APBA1 C1R C7	8.01e-05	185	55	4	e1fbec55b71f604189eb2431768fadbaa0453a83
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 APBA1 C1R C7	8.01e-05	185	55	4	9d933cd5ebc8368fd37aa83113d2dfa6938ff72d
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	THBS1 HMCN1 C1R C7	8.18e-05	186	55	4	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 CASR CYFIP2	8.18e-05	186	55	4	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 CASR CYFIP2	8.18e-05	186	55	4	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 CASR CYFIP2	8.35e-05	187	55	4	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPARGC1A TFCP2L1 CASR WWC1	8.35e-05	187	55	4	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 HMCN1 CASR	8.52e-05	188	55	4	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR CYFIP2	8.52e-05	188	55	4	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 HMCN1 CASR	8.52e-05	188	55	4	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 HMCN1 CASR CYFIP2	8.52e-05	188	55	4	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A HMCN1 CASR CYFIP2	8.70e-05	189	55	4	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 C1R C7 ARHGAP20	8.70e-05	189	55	4	e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 HMCN1 CASR	8.70e-05	189	55	4	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 HMCN1 CASR	8.70e-05	189	55	4	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR CYFIP2	8.70e-05	189	55	4	55420853f730b433ef58ac9337ac84ac78a247a0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR CYFIP2	8.88e-05	190	55	4	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 C1R C7 ARHGAP20	8.88e-05	190	55	4	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 CASR CYFIP2	8.88e-05	190	55	4	cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A TFCP2L1 CASR CYFIP2	9.06e-05	191	55	4	5a5b5402a077b3189ca156f2bac5f47ad780aebf
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A TFCP2L1 CASR CYFIP2	9.06e-05	191	55	4	78bcce497920cc5b3bef083eab50deb1cc82cd2e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KATNAL2 TFCP2L1 CASR	9.06e-05	191	55	4	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBS1 C1R C7 ARHGAP20	9.06e-05	191	55	4	4e4488380379ed29d7898bae4e24221e7c67eb9d
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	9.25e-05	192	55	4	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A TFCP2L1 CASR CYFIP2	9.25e-05	192	55	4	e19e3e8edcc08e4a67873bfb6e46489ca6c8756a
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 C1R C7 ARHGAP20	9.25e-05	192	55	4	f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR CYFIP2	9.25e-05	192	55	4	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	LPS-IL1RA-Stromal_mesenchymal\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 C1R C7 ARHGAP20	9.25e-05	192	55	4	4e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A TFCP2L1 CASR CYFIP2	9.25e-05	192	55	4	61c2caf6c838132ed5faa8791c288f2149eba2c8
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR CYFIP2	9.25e-05	192	55	4	32e4a180037e516c5cc798cd9dada9385e0f43ae
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBS1 CAPN6 C1R C7	9.43e-05	193	55	4	7c0d84b92470bfda2db1e5007feee7c1235a0a78
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	9.43e-05	193	55	4	c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 WWC1 CYFIP2	9.43e-05	193	55	4	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A TFCP2L1 CAPN6 CYFIP2	9.43e-05	193	55	4	b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	9.43e-05	193	55	4	5b602b1702283184bd3943c2a6f2290b7c37e407
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A TFCP2L1 CAPN6 CYFIP2	9.43e-05	193	55	4	241a60d1f0d5832638fb3e1e4b7afa7387ea3c75
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 WWC1 CYFIP2	9.62e-05	194	55	4	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	9.62e-05	194	55	4	240d122dcb9dd1ab2867503ad85869853adcacae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR WWC1	9.62e-05	194	55	4	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	9.62e-05	194	55	4	ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 C1R C7 ARHGAP20	9.62e-05	194	55	4	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	9.82e-05	195	55	4	d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	9.82e-05	195	55	4	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	9.82e-05	195	55	4	783bfa8110161cbd6def50ce849cae676c39c458
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	9.82e-05	195	55	4	44d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCell	ASK428-Epithelial-Transformed_epithelium\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	THBS1 DOCK11 C1R IFI16	9.82e-05	195	55	4	c750602c765a51075ba6ede78e3ba80b62374481
ToppCell	ASK452\|World / Donor, Lineage and Cell class of Lung cells from Dropseq	THBS1 C1R C7 IFI16	9.82e-05	195	55	4	7efd9d3a3f5e7dfe9698a4143ce4a0f9bf3a862c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	1.00e-04	196	55	4	ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 WWC1 CYFIP2	1.00e-04	196	55	4	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	1.00e-04	196	55	4	30ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	1.00e-04	196	55	4	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	1.00e-04	196	55	4	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 WWC1 CYFIP2	1.00e-04	196	55	4	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 AFF3 C1R C7	1.02e-04	197	55	4	09946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	THBS1 HMCN1 C1R C7	1.02e-04	197	55	4	94a9603cbd3516fbcce871909693b88f20d41713
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	THBS1 HMCN1 C1R C7	1.02e-04	197	55	4	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	AFF3 SPATA22 C7 ARHGAP20	1.02e-04	197	55	4	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	THBS1 HMCN1 C1R C7	1.02e-04	197	55	4	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR CYFIP2	1.04e-04	198	55	4	688b0eb5534dde40b8630ab8a3252c816711e02e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A TFCP2L1 CASR CYFIP2	1.04e-04	198	55	4	4448d13511485a44fe7b549e4b8b6ad7637db624
ToppCell	background-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	THBS1 HMCN1 C1R C7	1.04e-04	198	55	4	79f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	THBS1 HMCN1 C1R C7	1.04e-04	198	55	4	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN6 C1R C7 ARHGAP20	1.04e-04	198	55	4	d9ffc6589ed510ffa60c591f2a0fe123210f1455
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HMCN1 C1R C7 ARHGAP20	1.06e-04	199	55	4	7f4840ae6a888380feca722543e5e52783f3e35d
ToppCell	proximal-3-mesenchymal-Alveolar_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HMCN1 C1R C7 ARHGAP20	1.06e-04	199	55	4	301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN6 C1R C7 ARHGAP20	1.06e-04	199	55	4	bfc157be6e9f84739848eb19b718de5b17f3fa88
ToppCell	ASK452-Mesenchymal-Fibroblast\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	THBS1 HMCN1 C1R C7	1.06e-04	199	55	4	4d0bf2a4bd97e5a3bfe4570a201cc21bb9c4c1f6
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HMCN1 C1R C7 ARHGAP20	1.06e-04	199	55	4	9a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CYFIP1 PDGFB DOT1L ITGAX	1.06e-04	199	55	4	b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCell	ASK452-Mesenchymal\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	THBS1 HMCN1 C1R C7	1.06e-04	199	55	4	93e85e3731a9ece9aee3eb82c5dfdad331ee62d6
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HMCN1 C1R C7 ARHGAP20	1.06e-04	199	55	4	fb23ecce41e31e2cc01814e3c0add756f489561f
ToppCell	distal-mesenchymal-Alveolar_Fibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HMCN1 C1R C7 ARHGAP20	1.06e-04	199	55	4	655d07cf9a2fd9b945a2ed4f824cba0297de72a8
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuroepithelial\|6m / Sample Type, Dataset, Time_group, and Cell type.	CAPN6 C1R C7 IFI16	1.08e-04	200	55	4	2cc98abf11f5b58707de45a2282f03d47f00f035
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PDGFB AFF3 ZNF518B IFI16	1.08e-04	200	55	4	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
Drug	Dx11	APBA1 APBA2 ITGAX	2.30e-06	12	51	3	CID003009361
Drug	Mycophenolic acid [24280-93-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A	DCAF1 THBS1 HDAC4 PDGFB APBA2 ITIH2	5.06e-06	197	51	6	4137_DN
Drug	5-(3-((3-(5-methoxybenzisoxazol-3-yl)benzimidazol-1-yl)methyl)phenyl)-5-methyloxazolidinedione	PPARGC1A MED1	1.47e-05	3	51	2	ctd:C570539
Disease	chromosome 15q11.2 deletion syndrome (implicated_via_orthology)	CYFIP1 CYFIP2	7.77e-06	3	48	2	DOID:0060393 (implicated_via_orthology)
Disease	asthma	DCAF1 PREP AFF3 SLC30A8 CASR MED1 UNC79 CYFIP2	2.60e-05	751	48	8	MONDO_0004979
Disease	carbonic anhydrase 4 measurement	C7 ITIH2	3.87e-05	6	48	2	EFO_0020230
Disease	myocardial infarction (biomarker_via_orthology)	PPARGC1A THBS1 CASR C7	1.35e-04	160	48	4	DOID:5844 (biomarker_via_orthology)
Disease	complement factor D measurement	PPARGC1A ZNF518B C7	4.73e-04	93	48	3	EFO_0020283
Disease	FEV/FEC ratio	PPARGC1A HDAC4 HMCN1 PDGFB AFF3 ACVR1 ARHGAP20 CYFIP2	7.53e-04	1228	48	8	EFO_0004713
Disease	amyotrophic lateral sclerosis (is_marker_for)	PPARGC1A HDAC4	1.02e-03	29	48	2	DOID:332 (is_marker_for)
Disease	cytotoxicity measurement, response to clozapine	HMCN1 C7	1.02e-03	29	48	2	EFO_0006952, GO_0097338
Disease	Tinnitus	SPATA31A1 APBA1 ITGAX	1.25e-03	130	48	3	HP_0000360
Disease	Complement deficiency disease	C1R C7	1.32e-03	33	48	2	C0272242
Disease	visual epilepsy (implicated_via_orthology)	PDGFB C7	1.41e-03	34	48	2	DOID:11832 (implicated_via_orthology)
Disease	chronic kidney disease, diabetic nephropathy	AFF3 SLC30A8	1.58e-03	36	48	2	EFO_0000401, EFO_0003884

Protein segments in the cluster

Peptide	Gene	Start	Entry
VGRQQPRAKQVCNVE	AFF3	176	P51826
APLREQCQNPLRQKL	SLC4A9	206	Q96Q91
KQQQPVRRTVSQVCP	CFAP77	16	Q6ZQR2
PQQQRSQQQPRCKQK	CASR	951	P41180
KVVCVDQQRPNIPNR	ACVR1	446	Q04771
EQVCNGLEQPRKQQR	APBA2	316	Q99767
QRQQELLQLKSCVPP	DOT1L	651	Q8TEK3
CGKPVNPVEQRQRII	C1R	451	P00736
VRKERNPNPNCPQSD	CECR9	116	P0C854
NQPIPRRVTGCLQNK	RCBTB2	191	O95199
QNLRVVECKPQPCVV	RBM33	1086	Q96EV2
RTNENIQRFKICPTP	RASA1	391	P20936
QRLPVSRQECPRQEQ	ITGAX	136	P20702
RAIPQVKCNEQPNRV	CYFIP1	91	Q7L576
QCPEPKQRRQAPINF	DCAF1	1036	Q9Y4B6
PEKVLQQRPNANAVR	HDAC4	1001	P56524
FKPTVAQQRICPNCR	ITIH2	251	P19823
QQDQKVNIRVAVLPC	WWC1	691	Q8IX03
RRRKQPCRNQAAPAQ	EZHIP	146	Q86X51
NRNVQCRPTQVQLRP	PDGFB	136	P01127
CRPTQVQLRPVQVRK	PDGFB	141	P01127
SCQNLPKINQQRPRS	KATNAL2	116	Q8IYT4
ACQQGIPPTQVVRKA	LHX4	91	Q969G2
RAIPQVKCNEQPNRV	CYFIP2	91	Q96F07
PPDQQDKVQCAEVNR	GOLGA3	36	Q08378
AQTLRKNAQVRKCPP	GPR75	226	O95800
KVQVGQRVDIPCNAQ	HMCN1	1181	Q96RW7
ICQQQKPQRRPCSEL	PPARGC1A	196	Q9UBK2
QNKITVPFLEQCPIR	PREP	46	P48147
EQVQRNRAANPPVNI	ERVK-21	376	P62683
QTRNPQAVQPHLRKC	DNAH6	1206	Q9C0G6
RIPINCEQQINLKPI	DOCK11	1901	Q5JSL3
ARCVQKENPLTQAVP	C7	686	P10643
NQSRVKLNIVRCPPV	APBA1	731	Q02410
CQVTPRRNVLQKRPV	IFI16	191	Q16666
KLNVCRNVNNPIFGR	CAPN6	336	Q9Y6Q1
NPVSCPELVQQLREK	MED1	131	Q15648
NQNTEKVLPPRLNLC	ARHGAP20	916	Q9P2F6
CLPVPLFNQKKRNRQ	SPATA22	16	Q8NHS9
CPMVPREQFLQLQRQ	NIN	1986	Q8N4C6
RSKLVQEEPRNPNCQ	SPATA31A6	1076	Q5VVP1
QGCPNRDRQIRNQQP	SPATA31A7	1276	Q8IWB4
DQCRTIFLNKQPNPR	UBA2	411	Q9UBT2
CQELEQNRVPLQQKR	TFCP2L1	376	Q9NZI6
QQDNPRTCIQQNIPR	TRIOBP	811	Q9H2D6
QGCPNRDRQIRNQQP	SPATA31A3	1276	Q5VYP0
ELQQKPVNKDQCPRE	SLC30A8	26	Q8IWU4
GVQKRSRLCNNPTPQ	THBS1	511	P07996
TQRPKVRIQDVVPCN	RPA4	36	Q13156
QGCPNRDRQIRNQQP	SPATA31A1	1276	Q5TZJ5
QGCPNRDRQIRNQQP	SPATA31A5	1276	Q5VU36
VAQKQEPRVPTCVLQ	SPATA31D1	1266	Q6ZQQ2
RRCKNKFQPPQVPDQ	RRP8	196	O43159
QLVKCPRRNQPVVVL	ZNF518A	1336	Q6AHZ1
PEFVPAKNRIQTIQC	TTC17	1116	Q96AE7
NRNVVLVGQPVVRCA	ZNF350	481	Q9GZX5
QIQPGKRQCNVPTCL	UNC79	1946	Q9P2D8
DQLIKCPRRNQPVIV	ZNF518B	931	Q9C0D4