Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondiacylglycerol binding

UNC13A UNC13B UNC13C

3.54e-081693GO:0019992
GeneOntologyMolecularFunctionsyntaxin-1 binding

UNC13A UNC13B UNC13C

1.28e-072493GO:0017075
GeneOntologyMolecularFunctionphorbol ester receptor activity

UNC13B UNC13C

1.81e-07292GO:0001565
GeneOntologyMolecularFunctionnon-kinase phorbol ester receptor activity

UNC13B UNC13C

1.81e-07292GO:0001566
GeneOntologyMolecularFunctionsyntaxin binding

UNC13A UNC13B UNC13C

6.58e-068793GO:0019905
GeneOntologyMolecularFunctionSNARE binding

UNC13A UNC13B UNC13C

2.52e-0513693GO:0000149
GeneOntologyMolecularFunctioncalmodulin binding

UNC13A UNC13B UNC13C

1.20e-0423093GO:0005516
GeneOntologyMolecularFunctionphospholipid binding

UNC13A UNC13B UNC13C

1.53e-0354893GO:0005543
GeneOntologyMolecularFunctioncalcium ion binding

UNC13A UNC13B UNC13C

3.73e-0374993GO:0005509
GeneOntologyMolecularFunctionlipid binding

UNC13A UNC13B UNC13C

8.10e-0398893GO:0008289
GeneOntologyBiologicalProcessdense core granule priming

UNC13A UNC13B UNC13C

2.30e-10493GO:0061789
GeneOntologyBiologicalProcesspresynaptic dense core vesicle exocytosis

UNC13A UNC13B UNC13C

6.88e-091093GO:0099525
GeneOntologyBiologicalProcessneuronal dense core vesicle exocytosis

UNC13A UNC13B UNC13C

1.26e-081293GO:0099011
GeneOntologyBiologicalProcessdense core granule exocytosis

UNC13A UNC13B UNC13C

2.61e-081593GO:1990504
GeneOntologyBiologicalProcesssynaptic vesicle docking

UNC13A UNC13B UNC13C

3.89e-081793GO:0016081
GeneOntologyBiologicalProcesscalcium ion-regulated exocytosis of neurotransmitter

UNC13A UNC13B UNC13C

1.31e-072593GO:0048791
GeneOntologyBiologicalProcessdense core granule docking

UNC13A UNC13B

1.69e-07292GO:0061790
GeneOntologyBiologicalProcessdense core granule localization

UNC13A UNC13B UNC13C

1.87e-072893GO:0032253
GeneOntologyBiologicalProcesssynaptic vesicle priming

UNC13A UNC13B UNC13C

2.57e-073193GO:0016082
GeneOntologyBiologicalProcesssecretory granule localization

UNC13A UNC13B UNC13C

3.41e-073493GO:0032252
GeneOntologyBiologicalProcessvesicle docking involved in exocytosis

UNC13A UNC13B UNC13C

7.54e-074493GO:0006904
GeneOntologyBiologicalProcessvesicle docking

UNC13A UNC13B UNC13C

2.48e-066593GO:0048278
GeneOntologyBiologicalProcessnegative regulation of synaptic plasticity

UNC13B UNC13C

2.54e-06692GO:0031914
GeneOntologyBiologicalProcesscalcium-ion regulated exocytosis

UNC13A UNC13B UNC13C

5.00e-068293GO:0017156
GeneOntologyBiologicalProcessorganelle localization by membrane tethering

UNC13A UNC13B UNC13C

5.57e-068593GO:0140056
GeneOntologyBiologicalProcessmembrane docking

UNC13A UNC13B UNC13C

6.85e-069193GO:0022406
GeneOntologyBiologicalProcessexocytic process

UNC13A UNC13B UNC13C

1.11e-0510793GO:0140029
GeneOntologyBiologicalProcessregulation of synaptic vesicle priming

UNC13A UNC13B

1.54e-051492GO:0010807
GeneOntologyBiologicalProcesssynaptic vesicle exocytosis

UNC13A UNC13B UNC13C

1.78e-0512593GO:0016079
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

UNC13A UNC13B UNC13C

2.09e-0513293GO:0035249
GeneOntologyBiologicalProcessregulation of short-term neuronal synaptic plasticity

UNC13A UNC13B

3.89e-052292GO:0048172
GeneOntologyBiologicalProcessneurotransmitter secretion

UNC13A UNC13B UNC13C

6.70e-0519593GO:0007269
GeneOntologyBiologicalProcesssignal release from synapse

UNC13A UNC13B UNC13C

6.70e-0519593GO:0099643
GeneOntologyBiologicalProcessinnervation

UNC13A UNC13B

9.43e-053492GO:0060384
GeneOntologyBiologicalProcessestablishment of vesicle localization

UNC13A UNC13B UNC13C

1.01e-0422493GO:0051650
GeneOntologyBiologicalProcessvesicle localization

UNC13A UNC13B UNC13C

1.35e-0424793GO:0051648
GeneOntologyBiologicalProcessneurotransmitter transport

UNC13A UNC13B UNC13C

1.55e-0425993GO:0006836
GeneOntologyBiologicalProcesssynaptic vesicle cycle

UNC13A UNC13B UNC13C

1.64e-0426493GO:0099504
GeneOntologyBiologicalProcessregulated exocytosis

UNC13A UNC13B UNC13C

2.19e-0429193GO:0045055
GeneOntologyBiologicalProcessregulation of synaptic plasticity

UNC13A UNC13B UNC13C

2.24e-0429393GO:0048167
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

UNC13A UNC13B UNC13C

2.93e-0432193GO:0099003
GeneOntologyBiologicalProcessneuromuscular junction development

UNC13A UNC13B

3.80e-046892GO:0007528
GeneOntologyBiologicalProcessregulation of neuronal synaptic plasticity

UNC13A UNC13B

5.65e-048392GO:0048168
GeneOntologyBiologicalProcessexocytosis

UNC13A UNC13B UNC13C

7.07e-0443493GO:0006887
GeneOntologyBiologicalProcessnerve development

UNC13A UNC13B

9.72e-0410992GO:0021675
GeneOntologyBiologicalProcessregulation of neurotransmitter secretion

UNC13A UNC13B

1.14e-0311892GO:0046928
GeneOntologyBiologicalProcessestablishment of organelle localization

UNC13A UNC13B UNC13C

1.38e-0354693GO:0051656
GeneOntologyBiologicalProcessregulation of neurotransmitter transport

UNC13A UNC13B

1.62e-0314192GO:0051588
GeneOntologyBiologicalProcesssignal release

UNC13A UNC13B UNC13C

2.30e-0365393GO:0023061
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

UNC13A UNC13B UNC13C

2.40e-0366393GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

UNC13A UNC13B UNC13C

2.41e-0366493GO:0099177
GeneOntologyBiologicalProcessorganelle localization

UNC13A UNC13B UNC13C

2.84e-0370393GO:0051640
GeneOntologyBiologicalProcesschemical synaptic transmission

UNC13A UNC13B UNC13C

6.27e-0393193GO:0007268
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

UNC13A UNC13B UNC13C

6.27e-0393193GO:0098916
GeneOntologyBiologicalProcesstrans-synaptic signaling

UNC13A UNC13B UNC13C

6.43e-0393993GO:0099537
GeneOntologyBiologicalProcesssynaptic signaling

UNC13A UNC13B UNC13C

7.16e-0397693GO:0099536
GeneOntologyBiologicalProcesssecretion by cell

UNC13A UNC13B UNC13C

9.10e-03106493GO:0032940
GeneOntologyBiologicalProcessexport from cell

UNC13A UNC13B UNC13C

1.13e-02115393GO:0140352
GeneOntologyBiologicalProcesspositive regulation of secretion by cell

UNC13A UNC13B

1.26e-0240492GO:1903532
GeneOntologyBiologicalProcesssecretion

UNC13A UNC13B UNC13C

1.33e-02122193GO:0046903
GeneOntologyCellularComponentpresynaptic active zone cytoplasmic component

UNC13A UNC13B UNC13C

9.73e-082393GO:0098831
GeneOntologyCellularComponentcalyx of Held

UNC13A UNC13B UNC13C

3.91e-073693GO:0044305
GeneOntologyCellularComponentcell cortex region

UNC13A UNC13B UNC13C

7.76e-074593GO:0099738
GeneOntologyCellularComponentterminal bouton

UNC13A UNC13B UNC13C

7.73e-069693GO:0043195
GeneOntologyCellularComponentneuromuscular junction

UNC13A UNC13B UNC13C

1.23e-0511293GO:0031594
GeneOntologyCellularComponentpresynaptic active zone

UNC13A UNC13B UNC13C

2.45e-0514193GO:0048786
GeneOntologyCellularComponentexocytic vesicle membrane

UNC13A UNC13B UNC13C

4.99e-0517993GO:0099501
GeneOntologyCellularComponentsynaptic vesicle membrane

UNC13A UNC13B UNC13C

4.99e-0517993GO:0030672
GeneOntologyCellularComponentaxon terminus

UNC13A UNC13B UNC13C

8.03e-0521093GO:0043679
GeneOntologyCellularComponentneuron projection terminus

UNC13A UNC13B UNC13C

1.09e-0423393GO:0044306
GeneOntologyCellularComponentpresynaptic membrane

UNC13A UNC13B UNC13C

1.82e-0427793GO:0042734
GeneOntologyCellularComponenttransport vesicle membrane

UNC13A UNC13B UNC13C

2.15e-0429393GO:0030658
GeneOntologyCellularComponentsynaptic vesicle

UNC13A UNC13B UNC13C

2.31e-0430093GO:0008021
GeneOntologyCellularComponentexocytic vesicle

UNC13A UNC13B UNC13C

2.79e-0432093GO:0070382
GeneOntologyCellularComponentcytoplasmic region

UNC13A UNC13B UNC13C

3.94e-0436093GO:0099568
GeneOntologyCellularComponentcell cortex

UNC13A UNC13B UNC13C

4.30e-0437193GO:0005938
GeneOntologyCellularComponentdistal axon

UNC13A UNC13B UNC13C

6.85e-0443593GO:0150034
GeneOntologyCellularComponentexcitatory synapse

UNC13A UNC13C

9.13e-0410792GO:0060076
GeneOntologyCellularComponenttransport vesicle

UNC13A UNC13B UNC13C

1.14e-0351993GO:0030133
GeneOntologyCellularComponentsynaptic membrane

UNC13A UNC13B UNC13C

1.60e-0358393GO:0097060
GeneOntologyCellularComponentpresynapse

UNC13A UNC13B UNC13C

5.26e-0388693GO:0098793
GeneOntologyCellularComponentaxon

UNC13A UNC13B UNC13C

5.34e-0389193GO:0030424
GeneOntologyCellularComponentsecretory vesicle

UNC13A UNC13B UNC13C

1.35e-02124693GO:0099503
GeneOntologyCellularComponentcytoplasmic vesicle membrane

UNC13A UNC13B UNC13C

1.54e-02130793GO:0030659
GeneOntologyCellularComponentvesicle membrane

UNC13A UNC13B UNC13C

1.60e-02132593GO:0012506
DomainUnc-13

UNC13A UNC13B UNC13C

7.74e-11393IPR027080
DomainMHD2

UNC13A UNC13B UNC13C

7.73e-10593PS51259
DomainMunc13_dom-2

UNC13A UNC13B UNC13C

7.73e-10593IPR014772
DomainMunc13_subgr_dom-2

UNC13A UNC13B UNC13C

7.73e-10593IPR019558
DomainDUF1041

UNC13A UNC13B UNC13C

7.73e-10593SM01145
DomainMembr_traf_MHD

UNC13A UNC13B UNC13C

7.73e-10593PF10540
DomainDUF1041

UNC13A UNC13B UNC13C

2.71e-09793PF06292
DomainMHD1

UNC13A UNC13B UNC13C

2.71e-09793PS51258
DomainMunc13_1

UNC13A UNC13B UNC13C

2.71e-09793IPR014770
DomainCAPS_dom

UNC13A UNC13B UNC13C

2.71e-09793IPR010439
DomainC1_1

UNC13A UNC13B UNC13C

2.23e-065793PF00130
DomainZF_DAG_PE_2

UNC13A UNC13B UNC13C

3.18e-066493PS50081
DomainZF_DAG_PE_1

UNC13A UNC13B UNC13C

3.18e-066493PS00479
DomainC1

UNC13A UNC13B UNC13C

3.33e-066593SM00109
DomainPE/DAG-bd

UNC13A UNC13B UNC13C

3.49e-066693IPR002219
DomainC2

UNC13A UNC13B UNC13C

2.75e-0513193PF00168
DomainC2

UNC13A UNC13B UNC13C

3.14e-0513793SM00239
DomainC2

UNC13A UNC13B UNC13C

3.50e-0514293PS50004
Domain-

UNC13A UNC13B UNC13C

3.96e-05148932.60.40.150
DomainC2_dom

UNC13A UNC13B UNC13C

5.37e-0516493IPR000008
PathwayWP_SYNAPTIC_VESICLE_PATHWAY

UNC13A UNC13B UNC13C

2.47e-065183M39457
PathwayWP_16P112_PROXIMAL_DELETION_SYNDROME

UNC13A UNC13B

7.86e-047682M40057
Pubmed

Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.

UNC13A UNC13B UNC13C

1.20e-1139322966208
Pubmed

Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.

UNC13A UNC13B UNC13C

1.20e-1139333105896
Pubmed

Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.

UNC13A UNC13B UNC13C

1.20e-1139315988013
Pubmed

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.

UNC13A UNC13B UNC13C

1.20e-1139323658173
Pubmed

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.

UNC13A UNC13B UNC13C

1.20e-1059326575293
Pubmed

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.

UNC13A UNC13B UNC13C

1.20e-1059334706221
Pubmed

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.

UNC13A UNC13B UNC13C

4.19e-1079336398873
Pubmed

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.

UNC13A UNC13B UNC13C

6.71e-1089325609709
Pubmed

Molecular and functional architecture of striatal dopamine release sites.

UNC13A UNC13B UNC13C

1.97e-09119334767769
Pubmed

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

UNC13A UNC13B UNC13C

3.11e-08269317124501
Pubmed

The synaptic vesicle cycle.

UNC13A UNC13B UNC13C

5.37e-08319315217342
Pubmed

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.

UNC13A UNC13B

5.95e-0829228489077
Pubmed

Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.

UNC13A UNC13B

5.95e-0829231851910
Pubmed

A common molecular basis for membrane docking and functional priming of synaptic vesicles.

UNC13A UNC13B

5.95e-0829219558619
Pubmed

Regulation of insulin exocytosis by Munc13-1.

UNC13A UNC13B

5.95e-0829212871971
Pubmed

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.

UNC13A UNC13B

5.95e-0829218701688
Pubmed

Munc13 controls the location and efficiency of dense-core vesicle release in neurons.

UNC13A UNC13B

5.95e-0829223229896
Pubmed

Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.

UNC13A UNC13B

5.95e-0829232187536
Pubmed

Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.

UNC13A UNC13B

5.95e-0829217267576
Pubmed

A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.

UNC13A UNC13B

5.95e-0829235613050
Pubmed

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.

UNC13A UNC13B

5.95e-0829212070347
Pubmed

Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.

UNC13A UNC13B

5.95e-0829217561838
Pubmed

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.

UNC13A UNC13B

5.95e-0829211792326
Pubmed

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.

UNC13A UNC13B

5.95e-0829211832228
Pubmed

Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.

UNC13A UNC13B

5.95e-0829222814762
Pubmed

Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.

UNC13A UNC13B

5.95e-0829223770256
Pubmed

Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses.

UNC13B UNC13C

5.95e-0829222674279
Pubmed

Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.

UNC13A UNC13B

5.95e-0829223070049
Pubmed

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

UNC13A UNC13B

5.95e-0829228772123
Pubmed

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.

UNC13A UNC13B

5.95e-0829228426965
Pubmed

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.

UNC13A UNC13B

5.95e-0829210440375
Pubmed

Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.

UNC13A UNC13B

5.95e-0829222066784
Pubmed

Membrane bridging by Munc13-1 is crucial for neurotransmitter release.

UNC13A UNC13B

5.95e-0829230816091
Pubmed

Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.

UNC13A UNC13B

1.79e-0739217639022
Pubmed

Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.

UNC13A UNC13B

1.79e-0739237343100
Pubmed

Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo.

UNC13A UNC13B

3.57e-0749210488064
Pubmed

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.

UNC13A UNC13B

3.57e-0749219996097
Pubmed

Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.

UNC13A UNC13B

3.57e-0749215123597
Pubmed

ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

UNC13A UNC13B

3.57e-0749228264913
Pubmed

RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.

UNC13A UNC13B

5.95e-0759222248876
Pubmed

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.

UNC13A UNC13B

5.95e-0759232755572
Pubmed

Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.

UNC13A UNC13B

5.95e-0759233139401
Pubmed

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.

UNC13A UNC13B

8.92e-0769228635948
Pubmed

SNAREs and traffic.

UNC13A UNC13B

1.25e-0679215893389
Pubmed

SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming.

UNC13A UNC13B

2.68e-06109221040848
Pubmed

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.

UNC13A UNC13B

3.27e-06119225374362
InteractionUNC13C interactions

UNC13B UNC13C

1.17e-051292int:UNC13C
InteractionDIRAS1 interactions

UNC13A UNC13B

7.66e-053092int:DIRAS1
InteractionUBXN10 interactions

UNC13A UNC13B

1.51e-044292int:UBXN10
InteractionUNC13B interactions

UNC13B UNC13C

2.32e-045292int:UNC13B
GeneFamilyUNC13 homologs

UNC13A UNC13B UNC13C

1.42e-10473836
CoexpressionDESCARTES_MAIN_FETAL_GRANULE_NEURONS

UNC13C THSD7B

2.41e-052292M40087
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

UNC13A UNC13C THSD7B

3.01e-06150930205318a870e091add66ee4305747dda9f51510d
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma-2|TCGA-Cervix / Sample_Type by Project: Shred V9

THSD7B PTDSS1

1.89e-041049257d2a707aacaa90f92895b87f4ecf87b7451d667
ToppCellCOVID-19-kidney-Mito-rich_Int|COVID-19 / Disease (COVID-19 only), tissue and cell type

UNC13C THSD7B

2.59e-0412292a4220adb4e6055a599bd9bbf65d460fc4e68b543
ToppCellVE-CD4-CD8_1|VE / Condition, Cell_class and T cell subcluster

UNC13A ABHD1

2.64e-0412392bc0f509716bb71d6e3fa343f4920ecb80eb62794
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell|343B / Donor, Lineage, Cell class and subclass (all cells)

UNC13A KLRB1

3.22e-0413692b4a934feea46eeb10d407d1545bd225173078792
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|343B / Donor, Lineage, Cell class and subclass (all cells)

UNC13A KLRB1

3.27e-0413792885e4cfc237eca1fa2eb1f2fd8d84f151e21ecfa
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABHD1 KLRB1

3.36e-0413992ecc2a6ecc27748c50885cd4f0ad8a8cd1252aee6
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-innate_lymphocytic-immature_natural_killer_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

UNC13C KLRB1

3.71e-041469240fac8a298152ec7f7eeeed5a2d28541aea3b338
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

UNC13C THSD7B

3.81e-0414892d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_ALM_Trhr_Nefl|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

UNC13B UNC13C

3.86e-0414992558a441804dbcd5b5f39a3b1933b48976711ff15
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D175|Adult / Lineage, Cell type, age group and donor

UNC13A UNC13C

3.91e-0415092b0b6ba3686d3eb8a9b249d30be14111de3b893be
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-NP|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

UNC13B UNC13C

3.91e-04150922ba55e51877e2e749cccdae7df5d885dc55b2587
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD8-Trm_gut_CD8|bone_marrow / Manually curated celltypes from each tissue

UNC13A KLRB1

3.97e-04151925eebdc7ad6af3cc0263e4d8c3516818305ac38f2
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-AT1_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD7B PTDSS1

4.29e-0415792a93866f051472506f1468f379c0d5313e02c9731
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B UNC13C

4.34e-0415892f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B UNC13C

4.34e-04158928c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCelldroplet-Fat-SCAT-30m-Hematologic-erythroblast|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13C THSD7B

4.45e-0416092fc76337ad766c859db390ef8b6fb9caeaace3a56
ToppCelldroplet-Fat-SCAT-30m-Hematologic|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13C THSD7B

4.45e-0416092759749f708c3a2b36692d42499f19aff937e592f
ToppCelldroplet-Fat-SCAT-30m-Hematologic-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13C THSD7B

4.45e-041609267ee7a314d7d4d3ea206e0158083f36f6dd7e80b
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

UNC13A THSD7B

4.62e-041639219c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KLRB1 APOO

4.68e-041649284a1808bc6f501218ac2a5a05eb188a07ccd3890
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC13A KLRB1

4.73e-0416592cdc05f4a3c2c301f537ae641314875e5ecc16510
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC13A KLRB1

4.73e-0416592567c9f8fe29b5d34c2e39d9a17db54eba51ee559
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC13A KLRB1

4.73e-04165922ebabe6fdbcf8765bcf9d98faf20da783c9d113d
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KLRB1 APOO

4.85e-0416792e242827999caad08b0894d88ab97bc1df41b7650
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

UNC13C KLRB1

5.02e-04170926c65ddb496030bb479ef346cc37a9d4dfa6b824f
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

UNC13A UNC13C

5.08e-0417192b2e753e811a7639956994609f73efcdb62d04f82
ToppCell3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UNC13C KLRB1

5.32e-0417592f2c3e0f728a43d6988e793c8a50c964f7447db82
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 KLRB1

5.32e-041759206eace2e681980456299167b48bd49bcfea5e940
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

UNC13B KLRB1

5.38e-04176925914e7635474e7cf24d446bdb1423bc0807ee9c6
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UNC13A ABHD1

5.38e-0417692da5933eb253f13e70296a50a2bb00ad5c19a2d99
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

UNC13A THSD7B

5.44e-04177928abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 KLRB1

5.50e-0417892f94e306b9550f3d1b5de0bb806790c17823d439e
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

KLRB1 APOO

5.63e-0418092310a311c3ed924c912a800cf287a825de44b8775
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13A UNC13B

5.69e-04181927af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3|lymph-node_spleen / Manually curated celltypes from each tissue

UNC13C KLRB1

5.88e-0418492479e60f76c191253e23699c9dd7ef7efc08c59ad
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

UNC13B UNC13C

5.94e-0418592673f0c688ae6984bc8027df2da335787924f4137
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 KLRB1

5.94e-0418592f1263899a2d41d182022dc4ca62cbae08a463c89
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B UHRF2

6.00e-0418692f5468e03321ea2083e223eb0d92c3a9307039569
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13C THSD7B

6.13e-04188928268574584e5fb869a6cb8bbd7135cd7454a6a25
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 KLRB1

6.20e-0418992d05e043d0874b8563b9f5514f6c884b35c603e3a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13C THSD7B

6.26e-0419092be2b184a3559da41ba387ae0fdbeb9ae532868a5
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 KLRB1

6.26e-041909291ba66d4b56c59523485b17738e93f14bb00afa4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13C THSD7B

6.26e-041909259720dfe9de1b980807644536c919d2a02ba69dd
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13C THSD7B

6.39e-0419292342842378c20267c5044bdd622515e8b9f895623
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13A UNC13C

6.53e-0419492d024cd75a97f048257e49cee9190fb2e79202ee2
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 PTDSS1

6.59e-0419592a4d36654b968acb1aea252ac203683939461f1d1
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 KLRB1

6.59e-04195924b9663509cc5e3f409f6d0d37640cb301a827d98
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 PTDSS1

6.59e-0419592cd811abd949ef201aef1c8515da5575ab1b1cfea
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 KLRB1

6.59e-0419592e06ff785c5542c86c335d956799e03f7ae8345a4
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

UNC13C KLRB1

6.59e-0419592d70b49f6b9c6c4422adb2936c837a1af7569fb0a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13A UNC13B

6.59e-04195922e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 KLRB1

6.59e-041959236c784709ee32174e05b457500339c3b8eee3244
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-ILC|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13C KLRB1

6.66e-04196921cc2b11764584129703ec61965e8ec4e051464e7
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 KLRB1

6.66e-0419692c9fb81a0578db6d278b8582d7b3add6c407e6dcf
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 PTDSS1

6.66e-04196920175b097ad1338a07afebe3b5c7fd0bb0bb950f7
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UHRF2 PTDSS1

6.66e-0419692fd756b247b2d8a291e8e71bec6f1e463d6557536
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-gd_T|ICU-SEP / Disease, condition lineage and cell class

KLRB1 APOO

6.80e-0419892b40899f8f5f32420fb4574069dd7afd9e7e70d91
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13A THSD7B

6.87e-0419992fbec5c034576cb1adaf05f6f97cc5525d19e0c1b
Diseaseepilepsy (implicated_via_orthology)

UNC13A UNC13B UNC13C

1.36e-0516393DOID:1826 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

UNC13A UNC13B UNC13C

2.32e-0519593DOID:1574 (implicated_via_orthology)
Diseasehuman papilloma virus infection, oropharynx cancer

UNC13C THSD7B

1.13e-045392EFO_0001668, EFO_1001931
Diseaseurinary albumin to creatinine ratio

UNC13C THSD7B

1.28e-0317992EFO_0007778
Diseaseneuropsychological test

UNC13C THSD7B

1.55e-0319792EFO_0003926
Diseaseobsolete aging

UHRF2 THSD7B

3.07e-0327992GO_0007568
Diseaseexecutive function measurement

UNC13C THSD7B

5.50e-0337692EFO_0009332
Diseasememory performance

UNC13B UNC13C

6.47e-0340992EFO_0004874
Diseaseage at menarche

UNC13C THSD7B

1.33e-0259492EFO_0004703
Diseaseamino acid measurement

UNC13C PTDSS1

1.71e-0267892EFO_0005134
DiseaseColorectal Carcinoma

UNC13B UHRF2

1.82e-0270292C0009402
Diseaseasthma

UNC13C UHRF2

2.07e-0275192MONDO_0004979

Protein segments in the cluster

PeptideGeneStartEntry
FEVWTATTPTYCYEC

UNC13A

556

Q9UPW8
ATTPTYCYECEGLLW

UNC13A

561

Q9UPW8
CEPYTTWCQETYSQT

APOO

71

Q9BUR5
CSITTETFYPTLWCF

ABHD1

56

Q96SE0
YWYCPSCKTDSSEVV

UHRF2

386

Q96PU4
EVWTATTPTYCYECE

UNC13C

1101

Q8NB66
EVWTATTPTYCYECE

UNC13B

481

O14795
VPCYSECNQYSWVVE

THSD7B

1051

Q9C0I4
YSECEDGTYSPEISW

PTDSS1

416

P48651
SVYSEYCSTEIRWIC

KLRB1

196

Q12918