Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-9 ERVK-24	8.03e-10	37	56	6	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-9 ERVK-24	9.51e-10	38	56	6	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7	3.39e-06	11	56	3	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7	7.44e-06	14	56	3	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7	2.68e-05	21	56	3	GO:0035613
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCB8 NDUFA9 NDUFB5 ABCA7 ABCB4	1.41e-04	178	56	5	GO:0015399
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7	1.52e-04	37	56	3	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7	1.64e-04	38	56	3	GO:0034061
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ERVK-8 RHBDD2 ERVK-19 ERVK-7 ERVK-9 ERVK-24	1.91e-04	430	56	7	GO:0004175
GeneOntologyMolecularFunction	phosphatidylcholine floppase activity	ABCA7 ABCB4	2.14e-04	8	56	2	GO:0090554
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7	2.91e-04	46	56	3	GO:0016893
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCB8 ABCA7 ABCB4	3.51e-04	49	56	3	GO:0140359
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	DHRS4L2 NDUFA9 NDUFB5	6.38e-04	60	56	3	GO:0016655
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 KMT2B ERVK-8 ERVK-19 ERVK-7 ERVK-9 ERVK-24 ALPI PML	7.73e-04	891	56	9	GO:0008270
GeneOntologyMolecularFunction	floppase activity	ABCA7 ABCB4	9.04e-04	16	56	2	GO:0140328
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7	1.42e-03	79	56	3	GO:0004521
GeneOntologyMolecularFunction	phosphatidylcholine transporter activity	ABCA7 ABCB4	1.42e-03	20	56	2	GO:0008525
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 ERVK-8 RHBDD2 ERVK-19 ERVK-7 ERVK-9 ERVK-24	2.25e-03	654	56	7	GO:0008233
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H	DHRS4L2 NDUFA9 NDUFB5	2.41e-03	95	56	3	GO:0016651
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA7 ABCB4	2.79e-03	28	56	2	GO:0140326
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCB8 ABCA7 ABCB4	3.55e-03	109	56	3	GO:0042626
GeneOntologyMolecularFunction	oxidoreductase activity	FASN DHRS4L2 MICAL3 HADHA NDUFA9 EPX NDUFB5	5.38e-03	766	56	7	GO:0016491
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	FASN DHRS4L2 HADHA	5.45e-03	127	56	3	GO:0016616
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 KMT2B ERVK-8 ERVK-19 ERVK-7 ERVK-9 ERVK-24 ALPI PML	5.50e-03	1189	56	9	GO:0046914
GeneOntologyMolecularFunction	NADH dehydrogenase (ubiquinone) activity	NDUFA9 NDUFB5	5.91e-03	41	56	2	GO:0008137
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 ERVK-8 ERVK-7 ARID1A	6.23e-03	262	56	4	GO:0140097
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 ERVK-7	6.58e-03	136	56	3	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-8 ERVK-7	6.58e-03	136	56	3	GO:0004519
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH-OH group of donors	FASN DHRS4L2 HADHA	6.85e-03	138	56	3	GO:0016614
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-8 ERVK-7	8.93e-03	152	56	3	GO:0016779
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ABCA7 ABCB4	9.02e-03	51	56	2	GO:0140303
GeneOntologyMolecularFunction	SH2 domain binding	DLC1 KHDRBS1	9.36e-03	52	56	2	GO:0042169
GeneOntologyMolecularFunction	active transmembrane transporter activity	ABCB8 NDUFA9 NDUFB5 ABCA7 ABCB4	1.07e-02	477	56	5	GO:0022804
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7	5.32e-06	13	56	3	GO:0015074
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 ERVK-7 PML	7.63e-05	83	56	4	GO:0006278
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-9	8.38e-05	85	56	4	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-9	8.38e-05	85	56	4	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-19 ERVK-9	1.00e-04	89	56	4	GO:0006949
Domain	PP-bd_ACP	MRPL50 FASN	1.00e-04	6	49	2	IPR009081
Domain	ABC_transporter_CS	ABCB8 ABCA7 ABCB4	1.81e-04	42	49	3	IPR017871
Domain	ABC_tran	ABCB8 ABCA7 ABCB4	2.70e-04	48	49	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCB8 ABCA7 ABCB4	2.70e-04	48	49	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCB8 ABCA7 ABCB4	2.87e-04	49	49	3	PS00211
Domain	ABC_transporter-like	ABCB8 ABCA7 ABCB4	3.05e-04	50	49	3	IPR003439
Domain	AAA+_ATPase	ABCB8 KATNAL1 ABCA7 ABCB4	5.49e-04	144	49	4	IPR003593
Domain	AAA	ABCB8 KATNAL1 ABCA7 ABCB4	5.49e-04	144	49	4	SM00382
Domain	ABC_membrane	ABCB8 ABCB4	1.79e-03	24	49	2	PF00664
Domain	GroES-like	FASN ABCA7	1.79e-03	24	49	2	IPR011032
Domain	ABC_TM1F	ABCB8 ABCB4	2.44e-03	28	49	2	PS50929
Domain	ABC1_TM_dom	ABCB8 ABCB4	2.44e-03	28	49	2	IPR011527
Pathway	KEGG_ABC_TRANSPORTERS	ABCB8 ABCA7 ABCB4	2.05e-04	44	37	3	M11911
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_LIPOGENESIS	FASN SREBF1	2.39e-04	9	37	2	M29789
Pathway	WP_LIVER_X_RECEPTOR_PATHWAY	FASN SREBF1	2.98e-04	10	37	2	M39557
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-9	2.95e-09	12	56	4	14557543
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-9 ERVK-24	9.65e-09	94	56	6	21542922
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-24	1.58e-08	4	56	3	10469592
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-7	3.94e-08	5	56	3	12629516
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	7.88e-08	6	56	3	15063128
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	DHRS4L2 GLS ABCB8 HADHA NDUFA9 TNNI3 NDUFB5	1.03e-06	331	56	7	29199018
Pubmed	Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.	FASN SREBF1	2.55e-06	2	56	2	12213084
Pubmed	SREBP1/FASN/cholesterol axis facilitates radioresistance in colorectal cancer.	FASN SREBF1	2.55e-06	2	56	2	33665967
Pubmed	Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2.	FASN SREBF1	2.55e-06	2	56	2	18420801
Pubmed	Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals.	FASN SREBF1	2.55e-06	2	56	2	12897158
Pubmed	Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.	FASN SREBF1	2.55e-06	2	56	2	18281474
Pubmed	Reduced expression of FASN through SREBP-1 down-regulation is responsible for hypoxic cell death in HepG2 cells.	FASN SREBF1	2.55e-06	2	56	2	22786746
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	2.55e-06	2	56	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	2.55e-06	2	56	2	9460924
Pubmed	Sterol regulatory element-binding protein-1/fatty acid synthase involvement in proliferation inhibition and apoptosis promotion induced by progesterone in endometrial cancer.	FASN SREBF1	2.55e-06	2	56	2	24105476
Pubmed	Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids.	FASN GLS	7.63e-06	3	56	2	26134042
Pubmed	Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk.	FASN SREBF1	7.63e-06	3	56	2	19252981
Pubmed	FAS/SREBP-1c contributes to colorectal carcinogenesis through calcium signaling pathway and cAMP signaling pathway.	FASN SREBF1	7.63e-06	3	56	2	38143182
Pubmed	Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure.	GLS TNNI3	7.63e-06	3	56	2	33542341
Pubmed	B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.	FASN SREBF1	7.63e-06	3	56	2	27939887
Pubmed	Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c.	FASN SREBF1	7.63e-06	3	56	2	12531699
Pubmed	Histone modifications in FASN modulated by sterol regulatory element-binding protein 1c and carbohydrate responsive-element binding protein under insulin stimulation are related to NAFLD.	FASN SREBF1	7.63e-06	3	56	2	28027934
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	7.63e-06	3	56	2	10516026
Pubmed	Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-1c/FASN axis.	FASN SREBF1	7.63e-06	3	56	2	33649289
Pubmed	The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers.	FASN GLS	7.63e-06	3	56	2	32698888
Pubmed	Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).	FASN SREBF1	7.63e-06	3	56	2	18682402
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	7.63e-06	3	56	2	9971820
Pubmed	Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma.	FASN SREBF1	7.63e-06	3	56	2	30914315
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	FASN MAGED2 HADHA ARID1A	8.28e-06	79	56	4	26446488
Pubmed	Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.	FASN KHDRBS1 HADHA	1.13e-05	27	56	3	36266428
Pubmed	HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the SREBP1c/FASN Pathway.	FASN SREBF1	1.52e-05	4	56	2	25855506
Pubmed	Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter.	FASN SREBF1	1.52e-05	4	56	2	22331133
Pubmed	Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells.	FASN SREBF1	1.52e-05	4	56	2	23184344
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19	1.52e-05	4	56	2	7983737
Pubmed	The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element-binding protein-1 activation in cancer cells.	FASN SREBF1	1.52e-05	4	56	2	20067991
Pubmed	Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver.	FASN SREBF1	1.52e-05	4	56	2	9890958
Pubmed	Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells.	FASN SREBF1	1.52e-05	4	56	2	19621387
Pubmed	γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6.	FASN SREBF1	1.52e-05	4	56	2	23727646
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FASN KHDRBS1 ZBED4 MAGED2 GLS NOL6 UTP14A HADHA EPX ARID1A ABCB4	1.60e-05	1442	56	11	35575683
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	FASN KHDRBS1 MAGED2 NOL6 UTP14A HADHA NSRP1 GOT1	1.81e-05	714	56	8	28302793
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	DHRS4L2 GLS ABCB8 HADHA NDUFA9 NDUFB5	1.89e-05	343	56	6	28130547
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FASN ABCB8 NOL6 SREBF1 RHBDD2 NDUFA9 NDUFB5 NSRP1 EXOC8 PML	1.98e-05	1203	56	10	29180619
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	MRPL50 KHDRBS1 MAGED2 TELO2 GLS UTP14A SCYL1 HADHA HERC1 NDUFA9 NDUFB5	2.25e-05	1496	56	11	32877691
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	2.54e-05	5	56	2	11401426
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FASN KHDRBS1 GLS NOL6 UTP14A HADHA NDUFA9 NSRP1 PML	2.68e-05	989	56	9	36424410
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	FASN KHDRBS1 MAGED2 GLS NOL6 UTP14A ISOC1 HADHA NDUFA9 PML	2.88e-05	1257	56	10	36526897
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	DHRS4L2 GLS ABCB8 HADHA NDUFA9 NDUFB5	3.45e-05	382	56	6	29222160
Pubmed	KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.	FASN SREBF1	3.80e-05	6	56	2	27545894
Pubmed	Identifying strategies to target the metabolic flexibility of tumours.	FASN GLS	3.80e-05	6	56	2	32694609
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	MRPL50 FASN HADHA HERC1	5.54e-05	128	56	4	28027390
Pubmed	In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.	FASN SREBF1 ABCB4	6.10e-05	47	56	3	16498401
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	FASN KHDRBS1 UTP14A SCYL1 HADHA	8.05e-05	274	56	5	34244482
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	FASN KHDRBS1 SYN2 MICAL3 LRRC7 HADHA NDUFA9 ARID1A NDUFB5 GOT1	8.53e-05	1431	56	10	37142655
Pubmed	cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells.	FASN SREBF1	9.10e-05	9	56	2	23637738
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19	1.14e-04	10	56	2	12970426
Pubmed	A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.	KMT2B HADHA ARID1A	1.33e-04	61	56	3	20305087
Pubmed	Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.	FASN SREBF1	1.66e-04	12	56	2	27307439
Pubmed	Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.	FASN SREBF1 NDUFA9	1.76e-04	67	56	3	16806233
Pubmed	FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse.	GLS ALPI	1.96e-04	13	56	2	9107685
Pubmed	Identification and Characterization of USP7 Targets in Cancer Cells.	MAGED2 NSRP1	1.96e-04	13	56	2	30367141
Pubmed	Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.	FASN SREBF1	2.29e-04	14	56	2	25249504
Pubmed	Polymorphisms in mitochondrial genes and prostate cancer risk.	HADHA NDUFA9 NDUFB5	2.36e-04	74	56	3	19064571
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	ABCB8 NDUFB5 ABCA7 ABCB4	2.69e-04	193	56	4	19343046
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MAGED2 TELO2 GLS HADHA NDUFA9 EXOC8	2.78e-04	560	56	6	35241646
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	MAGED2 SCYL1 MICAL3 NSRP1 PML	2.86e-04	360	56	5	33111431
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FASN MAGED2 GLS NOL6 UTP14A ISOC1 HADHA NDUFA9 ARID1A	2.89e-04	1353	56	9	29467282
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	FASN MAGED2 GLS SCYL1 HADHA ARID1A GOT1	2.96e-04	803	56	7	36517590
Pubmed	Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.	FASN SREBF1	3.01e-04	16	56	2	8833906
Pubmed	C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.	FASN SREBF1	3.41e-04	17	56	2	10982846
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FASN KMT2B ZBED4 SREBF1 MICAL3 HERC1 ARID1A ABCA7	3.72e-04	1105	56	8	35748872
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-9 ERVK-24	3.83e-04	18	56	2	18664271
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	KHDRBS1 MAGED2 HADHA NDUFA9	4.06e-04	215	56	4	30462309
Pubmed	Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF.	KHDRBS1 MAGED2 ARID1A	4.21e-04	90	56	3	30459231
Pubmed	SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.	FASN SREBF1	4.28e-04	19	56	2	26685326
Pubmed	FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.	FASN SREBF1	4.28e-04	19	56	2	34348145
Pubmed	Human transcription factor protein interaction networks.	MRPL50 KMT2B KHDRBS1 MAGED2 UTP14A HADHA HERC1 ARID1A PML	4.32e-04	1429	56	9	35140242
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	FASN GLS HADHA NDUFA9 NDUFB5 GOT1 PML	4.43e-04	859	56	7	31536960
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MRPL50 FASN TELO2 NOL6 MICAL3 HADHA NDUFA9 ALPI PML	4.56e-04	1440	56	9	30833792
Pubmed	Adiponectin enhances mouse fetal fat deposition.	FASN SREBF1	4.75e-04	20	56	2	22872236
Pubmed	PPARα-Target Gene Expression Requires TIS21/BTG2 Gene in Liver of the C57BL/6 Mice under Fasting Condition.	FASN SREBF1	4.75e-04	20	56	2	29385670
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	FASN MAN2A1 GLS RHBDD2 CCDC80 HADHA NDUFA9 ARID1A NDUFB5	4.82e-04	1451	56	9	30550785
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	FASN HYPK MAGED2 TELO2 GLS SCYL1 ISOC1 HERC1 GOT1	4.92e-04	1455	56	9	22863883
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	MAGED2 SCYL1 HADHA PML	5.67e-04	235	56	4	28378594
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MRPL50 TELO2 GLS UTP14A HADHA NDUFA9 NDUFB5 NSRP1 PML	5.75e-04	1487	56	9	33957083
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	FASN SREBF1	5.76e-04	22	56	2	20965718
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	MAGED2 NOL6 LCA5L SCYL1 HERC1	5.78e-04	420	56	5	28065597
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	NOL6 UTP14A SREBF1 RHBDD2 MICAL3 EXOC8	6.12e-04	650	56	6	38777146
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCB8 ABCA7	6.30e-04	23	56	2	10708515
Pubmed	Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.	FASN SREBF1	6.30e-04	23	56	2	26508642
Pubmed	Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.	FASN SREBF1	6.30e-04	23	56	2	27974211
Pubmed	Local regulation of fat metabolism in peripheral nerves.	FASN SREBF1	6.30e-04	23	56	2	14522948
Pubmed	ATP-citrate lyase deficiency in the mouse.	FASN SREBF1	6.30e-04	23	56	2	14662765
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	MAGED2 TELO2 MICAL3	6.42e-04	104	56	3	31240132
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	FASN MAGED2 TELO2 NDUFA9 NSRP1 EXOC8	6.47e-04	657	56	6	36180527
Pubmed	Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation.	TNNI3 ARID1A	6.87e-04	24	56	2	37543677
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	MRPL50 FASN GLS ABCB8 HADHA NDUFA9 NDUFB5	6.91e-04	926	56	7	20877624
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	FASN RHBDD2 MICAL3 ARID1A NSRP1 PML	7.16e-04	670	56	6	22990118
Pubmed	CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.	HADHA NDUFA9	7.46e-04	25	56	2	28188211
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	MRPL50 KHDRBS1 NOL6 UTP14A HADHA NDUFA9	7.62e-04	678	56	6	30209976
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	FASN MAGED2 TELO2 SCYL1 HADHA NDUFA9 EXOC8	7.64e-04	942	56	7	31073040
Interaction	ZBTB7A interactions	FASN KHDRBS1 MAGED2 SREBF1 HADHA ARID1A	1.07e-06	131	52	6	int:ZBTB7A
Interaction	ATP5MF interactions	MRPL50 HYPK HADHA NDUFA9 NDUFB5 PML	6.14e-06	177	52	6	int:ATP5MF
Interaction	MYL12A interactions	HYPK GLS HADHA HERC1 NDUFA9 PML	9.78e-06	192	52	6	int:MYL12A
Cytoband	15q22	HERC1 PML	5.60e-04	29	55	2	15q22
GeneFamily	ATP binding cassette subfamily B	ABCB8 ABCB4	1.65e-04	11	32	2	806
GeneFamily	Short chain dehydrogenase/reductase superfamily	FASN DHRS4L2 NDUFA9	3.24e-04	76	32	3	743
GeneFamily	NADH:ubiquinone oxidoreductase supernumerary subunits	NDUFA9 NDUFB5	1.28e-03	30	32	2	1150
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GLS SYN2 CALY LRRC7 HERC1	2.83e-06	198	50	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
Drug	2,4,5-Trichlorophenoxyacetic Acid	SREBF1 ABCA7 GOT1 ACAP3 ALPI ABCB4	1.42e-07	107	51	6	ctd:D015085
Drug	AC1L1B78	FASN MAN2A1 LRRC7 ALPI PML	5.76e-07	72	51	5	CID000001313
Drug	N-piperidinyl-(8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo(6,7)cyclohepta(1,2-c)pyrazole-3-carboxamide)	FASN SREBF1	1.47e-05	3	51	2	ctd:C475771
Disease	aspartate aminotransferase to alanine aminotransferase ratio	SYN2 ARID1A GOT1 TMEM236 ABCB4	4.31e-05	239	48	5	EFO_0010934
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	FASN SREBF1 HADHA	1.64e-04	65	48	3	DOID:0080208 (biomarker_via_orthology)
Disease	eotaxin measurement	TELO2 RHBDD2 MICAL3	3.04e-04	80	48	3	EFO_0008122
Disease	transforming growth factor beta measurement	DLC1 DLEU7	8.86e-04	27	48	2	EFO_0004818
Disease	Malignant Neoplasms	FASN DLC1 ARID1A	1.20e-03	128	48	3	C0006826
Disease	Acute Coronary Syndrome	FASN TNNI3	1.32e-03	33	48	2	C0948089
Disease	Liver carcinoma	FASN KMT2B SREBF1 ARID1A ABCB4	1.37e-03	507	48	5	C2239176

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRRDSDHRERAMMTM	ERVK-19	661	O71037
LRRDSDHRERAMMTM	ERVK-8	661	Q902F8
RRDSDHRERAMMTMA	ERVK-9	661	Q9UKH3
TLLRLARMAEEMREA	ACAP3	786	Q96P50
RLRDTMRAMGLSRAV	ABCA7	576	Q8IZY2
EMIRDEGSSARSRML	CCDC80	116	Q76M96
METLMRSLDARLRAA	OLFM2	96	O95897
TVMSARDRYLARQMA	NSRP1	531	Q9H0G5
VSALRRFALSAMDME	GLS	566	O94925
TSVDMMRRAARALLA	ARID1A	2226	O14497
SVRMASSRMTRRDPL	DHRS4L2	16	Q6PKH6
SMMDRMFALERLART	ISOC1	241	Q96CN7
SQALRDAMARQLSRM	MICAL3	1606	Q7RTP6
SKALMASMARRASRG	MAGED2	206	Q9UNF1
RMDRIMESHLRAAEI	MAN2A1	516	Q16706
TLAQMAMRSALARVV	DLEU7	111	Q6UYE1
ADSLVSATEMAMFRR	LRRC7	1116	Q96NW7
ARRLDMRSLECASMD	KATNIP	1376	O60303
ARTMVMRALSLLSVS	HERC1	3186	Q15751
NERLTSDRGRALMFM	EPX	211	P11678
ARLSMMLLDSRADDG	NOL6	441	Q9H6R4
MIAQRRDAMAHRILS	LCA5L	131	O95447
MDTMRSLRFISAEAL	LRRC14B	1	A6NHZ5
STRRATSLELPMAMR	KMT2B	2551	Q9UMN6
MAMAMSDSGASRLRR	EXOC8	1	Q8IYI6
MAAAAQSRVVRVLSM	NDUFA9	1	Q16795
LRRDSDHRERAMMTM	ERVK-7	1421	P63135
EILTRRLRSMAFKAM	ABCB4	781	P21439
SLMEMTEAALRLLSR	ALPI	306	P09923
RRLPTARMIAFAMAL	CALY	81	Q9NYX4
RRDSDHRERAMMTMA	ERVK-24	551	P61566
LRRDSDHRERAMMTM	ERVK-6	661	Q69384
RRDSDHRERAMMTMA	ERVK-7	551	P61567
TMADRILTMRSELRA	GOT1	326	P17174
AALDMMLTGRSIRAD	HADHA	196	P40939
MQRRDDPAARMSRSS	KHDRBS1	1	Q07666
LRRDSDHRERAMMTM	HERVK_113	661	Q902F9
MGLSLMRLDRFRDSI	FASN	506	P49327
ERMAVDMRRALFSSL	ABCB8	221	Q9NUT2
MFLDRAQRAGSVRMR	RTP2	76	Q5QGT7
MMNFLRRRLSDSSFI	SYN2	1	Q92777
TNVCRDASLMAMRRR	KATNAL1	421	Q9BW62
DASLMAMRRRINGLS	KATNAL1	426	Q9BW62
MAARSVSGITRRVFM	MRPL50	1	Q8N5N7
KMFSSTDRAMRIRLL	SCYL1	356	Q96KG9
RSAMAAVLAMRDLCR	PML	741	P29590
LRDSRDELLASMMAG	TELO2	376	Q9Y4R8
MTEMEISRAAAERSL	HYPK	91	Q9NX55
DRDRARLDSMVLLIM	DLC1	346	Q96QB1
AMRRVFLHEATARLM	SREBF1	1031	P36956
LSANRGDMRRMRSCI	TMEM17	181	Q86X19
DSLMRARAAVRAMGT	ZSCAN20	566	P17040
AMLGVTTVRSRMRRA	RHBDD2	141	Q6NTF9
TTVRSRMRRALVFGM	RHBDD2	146	Q6NTF9
MVRVRAVVMARDDSS	SPRED3	1	Q2MJR0
MAAMSLLRRVSVTAV	NDUFB5	1	O43674
SLRAMSLEEAKMRRA	UTP14A	211	Q9BVJ6
RPTLRRVRISADAMM	TNNI3	141	P19429
DSGILRMMSRRDVRA	TMEM236	221	Q5W0B7
MLRSLKEAMVSRLSA	ZBED4	981	O75132