Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintramolecular transferase activity

PGM2 PUS7L

2.41e-0429162GO:0016866
GeneOntologyBiologicalProcessimmunoglobulin production

IGKV1D-33 IGLV3-10 IGKV6D-41 IGLV5-37 IGLV3-25 IGLV3-16

8.08e-08241206GO:0002377
GeneOntologyBiologicalProcessproduction of molecular mediator of immune response

IGKV1D-33 IGLV3-10 IGKV6D-41 IGLV5-37 IGLV3-25 IGLV3-16

1.65e-06403206GO:0002440
GeneOntologyBiologicalProcessadaptive immune response

IGKV1D-33 IGLV3-10 IGKV6D-41 IGLV5-37 IGLV3-25 IGLV3-16

1.05e-04838206GO:0002250
GeneOntologyCellularComponentimmunoglobulin complex

IGKV1D-33 IGLV3-10 IGKV6D-41 IGLV5-37 IGLV3-25 IGLV3-16

8.10e-09166206GO:0019814
PathwayREACTOME_CD22_MEDIATED_BCR_REGULATION

IGKV1D-33 IGKV1-33 IGLV3-25

3.38e-0561153M27581
PathwayREACTOME_FCGR_ACTIVATION

IGKV1D-33 IGKV1-33 IGLV3-25

4.90e-0569153M27108
PathwayREACTOME_SCAVENGING_OF_HEME_FROM_PLASMA

IGKV1D-33 IGKV1-33 IGLV3-25

4.90e-0569153M27150
PathwayREACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

IGKV1D-33 IGKV1-33 IGLV3-25

5.33e-0571153M1078
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

IGKV1D-33 IGKV1-33 IGLV3-25

5.33e-0571153M27203
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

IGKV1D-33 IGKV1-33 IGLV3-25

7.62e-0580153M6121
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

IGKV1D-33 IGKV1-33 IGLV3-25

8.21e-0582153M27110
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

IGKV1D-33 IGKV1-33 IGLV3-25

9.46e-0586153M601
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

IGKV1D-33 IGKV1-33 IGLV3-25

9.46e-0586153M27206
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

IGKV1D-33 IGKV1-33 IGLV3-25

9.79e-0587153M27205
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

IGKV1D-33 IGKV1-33 IGLV3-25

1.27e-0495153M29842
PathwayREACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS

IGKV1D-33 IGKV1-33 IGLV3-25

1.40e-0498153M27152
PathwayREACTOME_COMPLEMENT_CASCADE

IGKV1D-33 IGKV1-33 IGLV3-25

2.24e-04115153M19752
PathwayREACTOME_PARASITE_INFECTION

IGKV1D-33 IGKV1-33 IGLV3-25

2.30e-04116153M29843
PathwayREACTOME_FERTILIZATION

CATSPER3 OVGP1

3.38e-0426152M26922
PathwayREACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION

IGKV1D-33 IGKV1-33 IGLV3-25

3.51e-04134153M29840
PathwayREACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION

IGKV1D-33 IGKV1-33 IGLV3-25

3.67e-04136153M27207
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

IGKV1D-33 IGKV1-33 IGLV3-25

4.25e-04143153M27107
PathwayREACTOME_REPRODUCTION

CATSPER3 OVGP1

4.52e-0430152MM17211
PathwayREACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS

IGKV1D-33 IGKV1-33 IGLV3-25

5.28e-04154153M39007
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

IGKV1D-33 IGKV1-33 IGLV3-25

6.57e-04166153M608
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

IGKV1D-33 IGKV1-33 IGLV3-25

9.15e-04186153M27175
PathwayREACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL

IGKV1D-33 IGKV1-33 IGLV3-25

9.73e-04190153M8240
PathwayREACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL

IGKV1D-33 IGKV1-33 IGLV3-25

1.03e-03194153M16312
PathwayREACTOME_SARS_COV_INFECTIONS

IGKV1D-33 IGKV1-33 ST6GAL1 IGLV3-25

1.25e-03471154M39009
PathwayREACTOME_LEISHMANIA_INFECTION

IGKV1D-33 IGKV1-33 IGLV3-25

1.47e-03219153M29836
PathwayREACTOME_VESICLE_MEDIATED_TRANSPORT

IGKV1D-33 IGKV1-33 COG7 IGLV3-25

6.01e-03725154M27507
Pubmed

Activation of C1r by proteolytic cleavage.

IGKV1D-33 IGLV5-37 IGLV3-25 IGLV3-16

1.19e-08432141249422
Pubmed

Recognition of immunoglobulins by Fcgamma receptors.

IGKV1D-33 IGLV5-37 IGLV3-25 IGLV3-16

1.88e-084821411955599
Pubmed

Sequence and evolution of the human germline V lambda repertoire.

IGLV3-10 IGLV5-37 IGLV3-25 IGLV3-16

2.04e-08492148951372
Pubmed

One-megabase sequence analysis of the human immunoglobulin lambda gene locus.

IGLV3-10 IGLV5-37 IGLV3-25 IGLV3-16

5.24e-071092149074928
Pubmed

Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequently expressed VL are heterogeneous.

IGKV1D-33 IGKV1-33

1.04e-0632121940382
Pubmed

Physicochemical and functional characterization of the C1r subunit of the first complement component.

IGLV5-37 IGLV3-25 IGLV3-16

3.02e-0647213814163
Pubmed

Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes.

IGKV1D-33 IGKV6D-41

2.16e-043621211298326
Cytoband22q11.2

IGLV3-10 IGLV5-37 IGLV3-25 IGLV3-16

2.57e-0712021422q11.2
Cytoband2p12

IGKV1D-33 IGKV1-33 IGKV6D-41

2.07e-051172132p12
CytobandEnsembl 112 genes in cytogenetic band chr22q11

IGLV3-10 IGLV5-37 IGLV3-25 IGLV3-16

3.62e-05419214chr22q11
CytobandEnsembl 112 genes in cytogenetic band chr2p11

IGKV1D-33 IGKV1-33 IGKV6D-41

1.23e-04213213chr2p11
GeneFamilyImmunoglobulin lambda locus at 22q11.2

IGLV3-10 IGLV5-37 IGLV3-25 IGLV3-16

7.18e-0789154353
GeneFamilyImmunoglobulin kappa locus at 2p11.2

IGKV1D-33 IGKV1-33 IGKV6D-41

4.08e-0583153351
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV1D-33 IGKV1-33 ST6GAL1 IGLV3-25 IGLV3-16

1.87e-081802156a777a308fa3160d31eda468db930e71862020b2
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1D-33 IGLV3-10 IGKV1-33 ST6GAL1 IGLV3-25

1.87e-08180215e3877f6ef5f54ff689058b4c996ab1851822f871
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1D-33 IGKV1-33 ST6GAL1 IGLV3-25 IGLV3-16

2.94e-081972159fe1b757f76c2d43d39aa9ac500eaba98723985c
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1D-33 IGKV1-33 IGLV5-37 ST6GAL1 IGLV3-25

3.09e-081992158e02d3a066e79e0f2024a10738e0ea070513ef19
ToppCellTCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-2|TCGA-Stomach / Sample_Type by Project: Shred V9

IGKV1D-33 IGKV1-33 IGKV6D-41 IGLV3-16

3.17e-071242149d62f997a1a389386e8d83652bdf109c2a1c96d8
ToppCelllung-Ciliated_Epithelia|lung / shred on tissue and cell subclass

DNAH7 RPGRIP1L KHSRP DCDC1

1.04e-0616721426cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCellControl-Lymphoid-B_Plasma|Control / Disease state, Lineage and Cell class

IGKV1D-33 ST6GAL1 IGLV3-25 IGLV3-16

1.17e-0617221461e33836b8cb0f347f3e699eb587a37073b6fa4c
ToppCellCOPD-Lymphoid-B_Plasma|World / Disease state, Lineage and Cell class

IGKV1D-33 IGLV3-10 ST6GAL1 IGLV3-25

1.26e-06175214d73ee324479172501481b54967a0f3bd870fcf3a
ToppCellIPF-Lymphoid-B_Plasma|IPF / Disease state, Lineage and Cell class

IGKV1D-33 IGLV3-10 IGKV1-33 ST6GAL1

1.29e-06176214e4f33f6cd140dd4fa3002bcd65ac8005d27865d1
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Pre-B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGLV3-10 IGKV1-33 IGLV3-25 IGLV3-16

1.57e-061852140fa7970709dc957dea95fabbd83263a0335babd5
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1D-33 IGKV1-33 IGLV5-37 ST6GAL1

1.93e-0619521413f4ee21568fd747608412d33559d10561dbb3c8
ToppCellBiopsy_IPF-Immune-Plasma_cells|Biopsy_IPF / Sample group, Lineage and Cell type

IGKV1D-33 IGLV3-10 ST6GAL1 IGLV3-25

1.97e-06196214a1b6a8000b86efcb07843998aa3a49bb1f54bcda
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1D-33 IGLV3-10 IGLV5-37 ST6GAL1

1.97e-06196214b3d5540fe8ab9a9cbb9ab5350f5cb0e1aae93584
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1D-33 IGKV1-33 ST6GAL1 IGLV3-25

2.01e-0619721476465bb2408c7c75f694e8f7cf1a606b796afc3a
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgG_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGKV1D-33 IGKV1-33 IGLV3-25 IGLV3-16

2.01e-06197214b754fad4f3caae6de95df901fd96ea8697fe41b1
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_cell-B_mature|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1D-33 IGLV3-10 IGKV1-33 IGLV3-25

2.01e-06197214da175e66d0a743a1b91d46f224b5ff1d37aa5410
ToppCellCiliated_cells-A-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

DNAH7 KHSRP DCDC1

4.71e-051512139d03ce73af15ef40c592d19b36aff46bebc14c40
ToppCellTransplant_Alveoli_and_parenchyma-Immune-B_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

IGKV1D-33 ST6GAL1 IGLV3-25

4.81e-0515221366f9190de155251a63a7a669374f342a75d22ea0
ToppCell10x5'-Lung-Lymphocytic_B-Memory_B_cells|Lung / Manually curated celltypes from each tissue

IGKV1D-33 IGKV1-33 ST6GAL1

6.94e-051722132cb2dc7cfd6db5a98a393b1a84c23abf3d692a53
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV1D-33 IGKV1-33 IGLV3-25

7.43e-05176213ad05dd934f4ac2e656b3455de091f4c8772de6c8
ToppCell-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

IGLV3-10 ST6GAL1 IGLV3-25

7.56e-05177213ae2d2e138946535596fa30a55207f261cafda461
ToppCell(2)_Plasma_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

IGLV3-10 ST6GAL1 IGLV3-16

7.56e-05177213ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV3-10 IGKV1-33 IGLV3-16

7.81e-05179213494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCellnormal_Lymph_Node-B_lymphocytes-Plasma_cells|normal_Lymph_Node / Location, Cell class and cell subclass

IGLV3-10 IGLV5-37 IGLV3-25

8.07e-05181213949ac3b60e7fb5968da4c4e872965fb4e10f4a35
ToppCell10x5'-Lung-Lymphocytic_B|Lung / Manually curated celltypes from each tissue

IGKV1D-33 IGLV3-10 ST6GAL1

8.21e-05182213310f94437d197eaaaf6e30e68063b33e94befe77
ToppCellcellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IGKV1D-33 ST6GAL1 IGLV3-25

8.34e-051832135ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV1D-33 IGLV3-10 IGLV3-25

8.34e-05183213cf5c98f451a568308c52da5c926543dd4836c6b2
ToppCellwk_20-22-Hematologic_Lymphocytic-B-CD5+_CCL22+_mature_B|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

IGKV1D-33 IGKV1-33 IGLV3-25

8.48e-051842135bb775253a10a14360b06a46aba46d162a9bd1f8
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGLV5-37 ST6GAL1 IGLV3-16

9.62e-051922133dddfc93c3c954c4416c7c1f1f161e4d1dcc1233
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH7 RPGRIP1L DCDC1

9.91e-051942134a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH7 COG7 RPGRIP1L

9.91e-051942135dffa578149104dda33774361e9e77b227b5f1ce
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1D-33 IGKV1-33 IGLV3-16

1.01e-04195213f3f7f1a77a1edd2b50a8211c76fe289738eb04cf
ToppCellCV-Moderate-1|Moderate / Virus stimulation, Condition and Cluster

HERC6 ST6GAL1 TRIM5

1.02e-04196213b50cfcd87c5b67806450cb8b3c6860ab97f6d3b1
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV1D-33 IGKV1-33 ST6GAL1

1.02e-04196213c38e7f533c619afe008de0e99042f7180c2da918
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH7 RPGRIP1L DCDC1

1.04e-0419721374a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellBiopsy_Control_(H.)-Immune-B_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

IGKV1D-33 IGLV5-37 ST6GAL1

1.04e-04197213c78e0cf394b9a4e10ebba61f6392d9b5a23db9d8
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ST6GAL1 IGLV3-25 IGLV3-16

1.04e-041972131e63879633f20646e44873ae6b662f6faf4806fd
ToppCellCOVID_vent-Lymphocytic-Plasma_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

IGKV1D-33 IGLV3-10 ST6GAL1

1.05e-04198213e84c5f712e1dea548d0e2aba6625598f9671d3a0
ToppCellCOVID_vent-Lymphocytic-Plasma_cell-IgG_Plasmablast|COVID_vent / Disease condition, Lineage, Cell class and subclass

IGKV1D-33 IGKV1-33 ST6GAL1

1.08e-04200213fee909730133ec9875e14f7deed2a351dd21dba4
ToppCell(05)_Ciliated-(1)_24hpi|(05)_Ciliated / shred by cell type and Timepoint

OVGP1 KHSRP

7.75e-048821276959e7e3f6fae07c9881a29c28ba847be406694
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CATSPER3 TRIM5

1.78e-0313421222c64b8c405f3752331b81c611d8e62bd58c07f7
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

CATSPER3 TRIM5

1.78e-031342129a9fa63b40d9bf94995d70ef19d2548cb418b138
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Medullary_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

IGLV3-10 IGLV3-16

1.89e-031382127931dda2843d8bfe0e54111cc65aed1a891fe4b2
ToppCellmetastatic_Lymph_Node-B_lymphocytes-Plasma_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

IGLV3-10 IGLV3-25

2.00e-031422125ba3a33c2ee20be8baaed97536ca6e9d1de6752f
ToppCellTransplant_Alveoli_and_parenchyma-Immune-B_cells|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

IGKV1D-33 IGLV3-25

2.08e-0314521234cff6df39ff05995041f0c231c60a50ad1a0c1c
ToppCellmetastatic_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

GATM IGLV3-25

2.20e-0314921204c696f5102b0fff7d80e0f8d12a3119b2b81898
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ST6GAL1 RPGRIP1L

2.22e-0315021253de595376a9fc92491dfd58ff25938b0bf79903
ToppCellTCGA-Lung|World / Sample_Type by Project: Shred V9

IGLV3-10 IGLV3-25

2.22e-031502128c133206786e8f22bb70f2a7de9c0cb7f9ea9313
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ST6GAL1 RPGRIP1L

2.22e-03150212e4b40b3243ed26d0c46bf196ac06e148834e7ed2
ToppCellMS-CD4-CD8_1|MS / Condition, Cell_class and T cell subcluster

DNAH7 CATSPER3

2.22e-031502127dc95c58b98d8c4c6c49fb1a03ec6ac24fb41f54
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

DNAH7 DCDC1

2.25e-031512128216462e723fec2797387929dde095370947e10a
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATM PUS7L

2.28e-0315221287a7116d0064a6051bdf28ce1e48bfc168273e66
ToppCell390C-Lymphocytic-Plasma_cell|390C / Donor, Lineage, Cell class and subclass (all cells)

IGKV1D-33 IGLV3-25

2.40e-031562120de2fc695bd5f8d4633c514f71ea941c88137bac
ToppCell390C-Lymphocytic-Plasma_cell-|390C / Donor, Lineage, Cell class and subclass (all cells)

IGKV1D-33 IGLV3-25

2.40e-031562124f92ca30755430db44402afc603d1ecd8bfc3617
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH7 RPGRIP1L

2.43e-03157212410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell10x5'-blood-Lymphocytic_T_CD4-Trm_Th1/Th17|blood / Manually curated celltypes from each tissue

PGM2 COG7

2.43e-03157212c99cb26d831c25038f2aa1b1c0f7ba52facb2e7a
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GATM NDUFA4

2.46e-03158212c736834269c89e003c61a62b63e4e50dbf0e1538
ToppCellnormal_Lung-B_lymphocytes-MALT_B_cells|normal_Lung / Location, Cell class and cell subclass

IGKV1D-33 IGLV3-25

2.49e-03159212fbd0131b66f4267f7b0d6c3ad874ad097b859074
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-MALT_B_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

IGKV1D-33 IGLV3-25

2.49e-03159212204e5a675f4684c9570c24c8d34bbf632fd8164a
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|World / disease group, cell group and cell class (v2)

IGLV3-10 GATM

2.52e-031602126722934e153b72039c3c4308557d0ef879a30638
ToppCell368C-Lymphocytic-Plasma_cell-|368C / Donor, Lineage, Cell class and subclass (all cells)

IGLV3-10 ST6GAL1

2.59e-03162212c21a54310b239d999bbc9d8fb5e8fda16e0bc336
ToppCell368C-Lymphocytic-Plasma_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

IGLV3-10 ST6GAL1

2.59e-03162212f945688815229c8386cbcbf46deee7df316fa8d3
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GATM PGM2

2.62e-031632127af3d3ae7e0de733a18d0486c7ffbb5a7ef7230a
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

COG7 RPGRIP1L

2.65e-03164212d2218d50e0e2d19f919dcb460b3840687c082810
ToppCell10x5'-blood-Lymphocytic_B-ABC_aged-B_memory|blood / Manually curated celltypes from each tissue

IGLV3-25 IGLV3-16

2.65e-031642120424b23fc540580e7c15c50a7a03dff7c25014fa
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DNAH7 DCDC1

2.68e-031652120c714e852f912b5749de4cb0895406673979b2e6
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DNAH7 DCDC1

2.68e-0316521282530f96aaefe28a13bad0474bbad043f127a86c
ToppCell390C-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGKV1D-33 IGLV3-25

2.71e-031662124ba3711a02d3695b27f7cefd7c60e3be009f5bef
ToppCell390C-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGKV1D-33 IGLV3-25

2.71e-0316621235f6ae2664935dda0d883b32a050ced843204f2d
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GATM NDUFA4

2.71e-0316621237f5264491d75af690dd94eea2cf7763f42b2a2a
ToppCell367C-Lymphocytic-Plasma_cell-|367C / Donor, Lineage, Cell class and subclass (all cells)

ST6GAL1 IGLV3-16

2.75e-03167212f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell367C-Lymphocytic-Plasma_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

ST6GAL1 IGLV3-16

2.75e-031672125e768cf24699893e05d1bcb1c92dba2336943a64
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

DNAH7 DCDC1

2.78e-03168212a086c306be430adf0632ba53e98cd8014d2de330
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV3-10 IGLV3-25

2.81e-03169212307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HERC6 ST6GAL1

2.81e-03169212987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH7 DCDC1

2.81e-03169212fba841664939c771881ba97f14ef1df6635c04ff
ToppCelltumor_Lung-B_lymphocytes-Plasma_cells|tumor_Lung / Location, Cell class and cell subclass

IGLV3-10 IGLV3-16

2.81e-03169212b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH7 DCDC1

2.81e-0316921214aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellNS-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH7 RPGRIP1L

2.84e-03170212f6a0162bb690dbc19ff1cec64cb933744ad3b496
ToppCellControl-Lymphoid-B_Plasma|World / Disease state, Lineage and Cell class

IGKV1D-33 ST6GAL1

2.84e-03170212fb05f49b7113470995b3c16683c54dc1a660b73a
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell-B_activate-7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV3-10 IGLV3-25

2.84e-03170212ee2ee67d90ae4596de8ccd620e37c82cf51651d4
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV3-10 IGLV3-25

2.84e-03170212d7ca0c6ce5d2b7de99346f87e07aa7fe728fa08a
ToppCellwk_08-11-Hematologic_Lymphocytic-B-Late_pro-B|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

IGKV1D-33 IGKV1-33

2.84e-03170212ad69ebfda452e19eedc453e1d07dacb844d64e47
ToppCellBAL-Mild-Lymphocyte-B-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV3-10 IGLV3-25

2.84e-0317021252787f6d529c285d9f0c04cc022710ead5b89b3f
ToppCellmetastatic_Brain-B_lymphocytes-Plasma_cells|metastatic_Brain / Location, Cell class and cell subclass

ST6GAL1 IGLV3-25

2.84e-0317021253634da9e9c72f6400639954c286c6e38ea5a188
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

HERC6 DNAH7

2.84e-031702120f215911b5880eeffeb43230f7eeaf55b612eaf2
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GATM RPGRIP1L

2.84e-03170212070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATM PGM2

2.88e-03171212f15594fd4d709920733de9376a391dedc62b65de
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATM PGM2

2.88e-03171212fea6ef6bbfebea2dd0f0360c7db7a5e858f15958
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GATM ST6GAL1

2.88e-03171212a2938e56cb5749004317798dc7ac0f0c2d4d8ae0
ToppCell3'_v3-Lung-Lymphocytic_B-Memory_B_cells|Lung / Manually curated celltypes from each tissue

IGLV3-10 ST6GAL1

2.88e-031712129ecef653f6916572bf5fbee5aea6c577d04e96ba
ToppCellwk_08-11-Hematologic_Lymphocytic-B|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

IGKV1D-33 IGKV1-33

2.91e-03172212d1ab8f493b70ec995281f9fb0991f1d3aa7b928f
ToppCellCiliated_cells-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

DNAH7 DCDC1

2.91e-03172212187ae91148d293537afc77e10da2b64302322224
ToppCell10x5'v1-week_12-13-Myeloid_macrophage-stroma-monocytoid_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

GATM ST6GAL1

2.91e-031722129befd44bce43eb5dc1fe3d2e44608f442cf74a47
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATM KHSRP

2.94e-031732120672bd8a4a9d18af343d01f09253fb3388896c10
ToppCell5'-Adult-Appendix-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGLV3-10 ST6GAL1

2.94e-0317321268bcc0eee15df9cf3516c641709154301bd7b38f
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATM KHSRP

2.94e-03173212869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATM KHSRP

2.94e-03173212870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCell10x5'-bone_marrow-Lymphocytic_B_plasma-Plasma_cells|bone_marrow / Manually curated celltypes from each tissue

IGKV1D-33 ST6GAL1

2.94e-03173212300904fd35536a69be81d76fe33fe16544523ceb
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH7 DCDC1

2.94e-03173212c3762655caa79ac4879876f470d32578a3c93b01
Drugraloxifene hydrochloride; Down 200; 0.1uM; HL60; HG-U133A

HERC6 COG7 OVGP1 PUS7L

9.30e-06198164388_DN
DrugFenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; PC3; HT_HG-U133A

ST6GAL1 OVGP1 RPGRIP1L KHSRP

9.49e-061991647298_UP
DrugPhenylpropanolamine hydrochloride [154-41-6]; Down 200; 21.4uM; PC3; HT_HG-U133A

HERC6 DNAH7 KHSRP

3.10e-041931636699_DN
DrugFenoterol hydrobromide [1944-12-3]; Down 200; 10.4uM; MCF7; HT_HG-U133A

HERC6 TRIM5 RPGRIP1L

3.10e-041931635432_DN
DrugSuramin sodium salt; Down 200; 10uM; PC3; HT_HG-U133A

HERC6 ST6GAL1 RPGRIP1L

3.14e-041941637529_DN
DrugPiroxicam [36322-90-4]; Down 200; 12uM; HL60; HG-U133A

COG7 OVGP1 PUS7L

3.14e-041941631405_DN
Drug5707885; Up 200; 50uM; MCF7; HT_HG-U133A

GATM DNAH7 OVGP1

3.19e-041951636433_UP
DrugThiethylperazine malate [52239-63-1]; Up 200; 6uM; MCF7; HT_HG-U133A

ST6GAL1 TRIM5 OVGP1

3.24e-041961636232_UP
DrugGuaifenesin [93-14-1]; Up 200; 20.2uM; HL60; HT_HG-U133A

GATM DNAH7 KHSRP

3.24e-041961632569_UP
DrugTiletamine hydrochloride; Up 200; 15.4uM; PC3; HT_HG-U133A

HERC6 DNAH7 RPGRIP1L

3.29e-041971637311_UP
DrugTrolox [53188-07-1]; Up 200; 16uM; PC3; HT_HG-U133A

DNAH7 OVGP1 KHSRP

3.29e-041971637304_UP
DrugN6-methyladenosine [1867-73-8]; Up 200; 14.2uM; MCF7; HT_HG-U133A

HERC6 PUS7L RPGRIP1L

3.29e-041971635332_UP
DrugTTNPB; Up 200; 0.1uM; PC3; HG-U133A

TRIM5 OVGP1 KHSRP

3.29e-04197163451_UP
DrugSulmazole [73384-60-8]; Down 200; 14uM; PC3; HT_HG-U133A

DNAH7 RPGRIP1L KHSRP

3.29e-041971634009_DN
DrugNetilmicin sulfate [56931-57-2]; Up 200; 2.8uM; PC3; HT_HG-U133A

GATM DNAH7 OVGP1

3.34e-041981637302_UP
DrugChrysin [480-40-0]; Up 200; 15.8uM; MCF7; HT_HG-U133A

GATM ST6GAL1 OVGP1

3.34e-041981636485_UP
DrugOxybenzone [131-57-7]; Up 200; 17.6uM; HL60; HT_HG-U133A

ST6GAL1 OVGP1 RPGRIP1L

3.34e-041981633092_UP
DrugSolasodine [126-17-0]; Down 200; 9.6uM; PC3; HT_HG-U133A

DNAH7 ST6GAL1 RPGRIP1L

3.34e-041981633749_DN
DrugGanciclovir [82410-32-0]; Up 200; 15.6uM; MCF7; HT_HG-U133A

GATM TRIM5 RPGRIP1L

3.39e-041991635389_UP
DrugEpitiostanol [2363-58-8]; Up 200; 13uM; PC3; HT_HG-U133A

HERC6 GATM ST6GAL1

3.39e-041991634204_UP
DrugDibucaine [85-79-0]; Up 200; 11.6uM; PC3; HG-U133A

ST6GAL1 OVGP1 PUS7L

3.39e-041991631889_UP
DrugOxolinic acid [14698-29-4]; Up 200; 15.4uM; PC3; HT_HG-U133A

HERC6 ST6GAL1 KHSRP

3.39e-041991635094_UP
DrugFenbendazole [43210-67-9]; Down 200; 13.4uM; PC3; HT_HG-U133A

HERC6 ST6GAL1 OVGP1

3.44e-042001634542_DN
DrugSimvastatin [79902-63-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A

HERC6 TRIM5 PUS7L

3.44e-042001634828_DN
Diseaset-tau:beta-amyloid 1-42 ratio measurement

OVGP1 KHSRP

6.56e-0466172EFO_0007708
DiseaseKidney Diseases

GATM RPGRIP1L

1.16e-0388172C0022658
Diseaseamino acid measurement

DNAH7 COG7 DCDC1

6.46e-03678173EFO_0005134
Diseasechronic kidney disease

GATM DCDC1

7.94e-03235172EFO_0003884
DiseaseDrugs used in diabetes use measurement

DNAH7 ST6GAL1

9.29e-03255172EFO_0009924

Protein segments in the cluster

PeptideGeneStartEntry
PDNLWASKNYYPKQN

C2orf16

1381

Q68DN1
KNPWQEYNYLQKDNP

COG7

526

P83436
KVYVDPINYWKNGYN

CATSPER3

101

Q86XQ3
LPKKYAYWYQQKPGQ

IGLV3-16

46

A0A075B6K0
DINVGSYNIYWYQQK

IGLV5-37

46

A0A075B6J1
LPKQYAYWYQQKPGQ

IGLV3-25

46

P01717
YKPYNNGAANQKWHY

DCDC1

1251

M0R2J8
ISNYLNWYQQKPGKA

IGKV1D-33

51

P01593
PKPKSGQWVYYNYSN

RPGRIP1L

1191

Q68CZ1
LPKKYAYWYQQKSGQ

IGLV3-10

46

A0A075B6K4
KANTYEKYWPFYQKQ

GATM

96

P50440
NYLYWYQQKPDQAPK

IGKV6D-41

51

A0A0C4DH26
YDWKQFEQNSKYEQG

HERC6

906

Q8IVU3
HNPKQDNGYKVYWDN

PGM2

166

Q96G03
WFPEVQNIYYQGNKK

DNAH7

331

Q8WXX0
ISNYLNWYQQKPGKA

IGKV1-33

51

P01594
YQYVPYANKGKEWVG

OVGP1

316

Q12889
AWEEYYKKIGQQPQQ

KHSRP

621

Q92945
YNIQYPKNKVGQWYH

PUS7L

601

Q9H0K6
EPWNKLGPNDQYKFY

NDUFA4

51

O00483
IPKWYQNPDYNFFNN

ST6GAL1

266

P15907
NIEKNENYQPKYGYW

TRIM5

386

Q9C035