Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	MAP kinase kinase kinase kinase activity	MAP4K3 MAP4K2	2.12e-04	6	76	2	GO:0008349
GeneOntologyMolecularFunction	iron-sulfur cluster binding	BRIP1 CISD2 XDH REV3L	2.23e-04	78	76	4	GO:0051536
GeneOntologyMolecularFunction	histone modifying activity	KDM5B KMT5B SETBP1 ASH1L PRKCA JADE1	2.39e-04	229	76	6	GO:0140993
GeneOntologyMolecularFunction	metal cluster binding	BRIP1 CISD2 XDH REV3L	2.84e-04	83	76	4	GO:0051540
GeneOntologyMolecularFunction	chromatin binding	NCOA2 TICRR TNRC18 BRIP1 ERCC6 KMT5B UBTF POLR2A ASH1L TTF1	4.77e-04	739	76	10	GO:0003682
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	IFIH1 BRIP1 ERCC6 POLR2A RPP38 MARF1 REV3L GEN1 DHX8	7.49e-04	645	76	9	GO:0140640
GeneOntologyBiologicalProcess	protein-DNA complex organization	KDM5B ZFP42 ERCC6 KMT5B ANP32B UBTF SETBP1 ASH1L NFRKB PRKCA SRPK1 ZDBF2 JADE1 TTF1	1.07e-05	999	74	14	GO:0071824
GeneOntologyBiologicalProcess	chromatin remodeling	KDM5B ZFP42 ERCC6 KMT5B ANP32B SETBP1 ASH1L NFRKB PRKCA ZDBF2 JADE1 TTF1	1.20e-05	741	74	12	GO:0006338
GeneOntologyBiologicalProcess	chromatin organization	KDM5B ZFP42 ERCC6 KMT5B ANP32B SETBP1 ASH1L NFRKB PRKCA SRPK1 ZDBF2 JADE1 TTF1	1.61e-05	896	74	13	GO:0006325
GeneOntologyBiologicalProcess	DNA repair	CUL4B CUL4A RAD51AP1 TICRR BRIP1 ERCC6 KMT5B NFRKB MARF1 REV3L GEN1	1.87e-05	648	74	11	GO:0006281
GeneOntologyBiologicalProcess	DNA metabolic process	CUL4B CUL4A RAD51AP1 TICRR BRIP1 ERCC6 KMT5B NFRKB MARF1 JADE1 REV3L CDC42 TTF1 GEN1	2.59e-05	1081	74	14	GO:0006259
GeneOntologyBiologicalProcess	cell cycle process	CUL4B CUL4A RAD51AP1 TICRR BRIP1 ERCC6 ANP32B MARF1 PRKCA SRPK1 JADE1 CCDC102B CENATAC CDC42 GEN1 DEUP1	4.16e-05	1441	74	16	GO:0022402
GeneOntologyBiologicalProcess	JNK cascade	ERCC6 MAP4K3 TIRAP PTPN22 CDC42 MAP4K2	7.81e-05	198	74	6	GO:0007254
GeneOntologyBiologicalProcess	DNA replication	TICRR NFRKB JADE1 REV3L CDC42 TTF1 GEN1	1.28e-04	312	74	7	GO:0006260
GeneOntologyBiologicalProcess	double-strand break repair	RAD51AP1 BRIP1 ERCC6 KMT5B MARF1 REV3L GEN1	1.62e-04	324	74	7	GO:0006302
GeneOntologyBiologicalProcess	regulation of DNA metabolic process	CUL4A RAD51AP1 TICRR ERCC6 KMT5B NFRKB JADE1 CDC42 TTF1	1.82e-04	564	74	9	GO:0051052
GeneOntologyBiologicalProcess	regulation of DNA replication	TICRR NFRKB JADE1 CDC42 TTF1	1.86e-04	147	74	5	GO:0006275
GeneOntologyBiologicalProcess	uterus morphogenesis	KDM5B ASH1L	1.89e-04	6	74	2	GO:0061038
GeneOntologyBiologicalProcess	regulation of cell cycle process	CUL4B CUL4A RAD51AP1 TICRR BRIP1 ERCC6 ANP32B JADE1 CENATAC CDC42 GEN1	2.02e-04	845	74	11	GO:0010564
GeneOntologyBiologicalProcess	negative regulation of cell cycle process	CUL4A TICRR BRIP1 ERCC6 JADE1 CENATAC GEN1	3.18e-04	362	74	7	GO:0010948
GeneOntologyBiologicalProcess	DNA recombination	RAD51AP1 BRIP1 ERCC6 KMT5B NFRKB REV3L GEN1	3.51e-04	368	74	7	GO:0006310
GeneOntologyBiologicalProcess	positive regulation of toll-like receptor 3 signaling pathway	TIRAP PTPN22	3.51e-04	8	74	2	GO:0034141
MousePheno	abnormal skin morphology	CUL4B NCOA2 IFIH1 ERCC6 KCNH8 CISD2 UBTF ASH1L PRKCA XDH SLCO1B3 DCN VPS13B PXK DHX8 PLCE1 BRWD1	2.60e-05	1455	55	17	MP:0002060
Domain	MAPKKKK	MAP4K3 MAP4K2	9.00e-05	4	73	2	IPR021160
Domain	Zinc_finger_PHD-type_CS	KDM5B PHF3 ASH1L JADE1	1.21e-04	65	73	4	IPR019786
Domain	PHD	KDM5B PHF3 ASH1L JADE1	2.12e-04	75	73	4	PF00628
Domain	Znf_PHD-finger	KDM5B PHF3 ASH1L JADE1	2.59e-04	79	73	4	IPR019787
Domain	Cullin_CS	CUL4B CUL4A	3.12e-04	7	73	2	IPR016157
Domain	CULLIN	CUL4B CUL4A	3.12e-04	7	73	2	SM00182
Domain	PHD	KDM5B PHF3 ASH1L JADE1	4.08e-04	89	73	4	SM00249
Domain	Cullin_Nedd8	CUL4B CUL4A	4.16e-04	8	73	2	PF10557
Domain	Cullin_Nedd8	CUL4B CUL4A	4.16e-04	8	73	2	SM00884
Domain	Cullin_neddylation_domain	CUL4B CUL4A	4.16e-04	8	73	2	IPR019559
Domain	Znf_PHD	KDM5B PHF3 ASH1L JADE1	4.44e-04	91	73	4	IPR001965
Domain	ZF_PHD_2	KDM5B PHF3 ASH1L JADE1	5.23e-04	95	73	4	PS50016
Domain	Cullin_homology	CUL4B CUL4A	5.33e-04	9	73	2	IPR016158
Domain	ZF_PHD_1	KDM5B PHF3 ASH1L JADE1	5.44e-04	96	73	4	PS01359
Domain	Cullin	CUL4B CUL4A	6.64e-04	10	73	2	PF00888
Domain	CULLIN_2	CUL4B CUL4A	6.64e-04	10	73	2	PS50069
Domain	Cullin_N	CUL4B CUL4A	6.64e-04	10	73	2	IPR001373
Domain	CULLIN_1	CUL4B CUL4A	6.64e-04	10	73	2	PS01256
Domain	PX	SNX14 NISCH PXK	6.76e-04	44	73	3	SM00312
Domain	BAH	TNRC18 ASH1L	8.10e-04	11	73	2	SM00439
Domain	BAH	TNRC18 ASH1L	8.10e-04	11	73	2	PF01426
Domain	BAH	TNRC18 ASH1L	8.10e-04	11	73	2	PS51038
Domain	BAH_dom	TNRC18 ASH1L	8.10e-04	11	73	2	IPR001025
Domain	DEXDc	IFIH1 BRIP1 ERCC6 DHX8	8.77e-04	109	73	4	SM00487
Domain	Helicase_ATP-bd	IFIH1 BRIP1 ERCC6 DHX8	9.07e-04	110	73	4	IPR014001
Domain	PX	SNX14 NISCH PXK	9.28e-04	49	73	3	PF00787
Domain	Cullin_repeat-like_dom	CUL4B CUL4A	9.70e-04	12	73	2	IPR016159
Domain	-	MARF1 GEN1	9.70e-04	12	73	2	3.40.50.1010
Domain	PX	SNX14 NISCH PXK	9.84e-04	50	73	3	PS50195
Domain	-	SNX14 NISCH PXK	1.04e-03	51	73	3	3.30.1520.10
Domain	Phox	SNX14 NISCH PXK	1.10e-03	52	73	3	IPR001683
Domain	PIN_domain-like	MARF1 GEN1	1.33e-03	14	73	2	IPR029060
Domain	CNH	MAP4K3 MAP4K2	1.33e-03	14	73	2	SM00036
Domain	CNH	MAP4K3 MAP4K2	1.53e-03	15	73	2	PF00780
Domain	CNH	MAP4K3 MAP4K2	1.53e-03	15	73	2	PS50219
Domain	CNH_dom	MAP4K3 MAP4K2	1.53e-03	15	73	2	IPR001180
Domain	UDENN	DENND2A DENND4C	1.75e-03	16	73	2	PS50946
Domain	DDENN	DENND2A DENND4C	1.75e-03	16	73	2	PS50947
Domain	DENN	DENND2A DENND4C	1.75e-03	16	73	2	SM00799
Domain	dDENN	DENND2A DENND4C	1.75e-03	16	73	2	SM00801
Domain	DENN	DENND2A DENND4C	1.75e-03	16	73	2	PF02141
Domain	dDENN_dom	DENND2A DENND4C	1.75e-03	16	73	2	IPR005112
Domain	uDENN_dom	DENND2A DENND4C	1.75e-03	16	73	2	IPR005113
Domain	dDENN	DENND2A DENND4C	1.75e-03	16	73	2	PF03455
Domain	DENN	DENND2A DENND4C	1.75e-03	16	73	2	PS50211
Domain	DENN_dom	DENND2A DENND4C	1.75e-03	16	73	2	IPR001194
Domain	Znf_FYVE_PHD	KDM5B PHF3 ASH1L JADE1	2.63e-03	147	73	4	IPR011011
Pathway	REACTOME_DNA_REPAIR	CUL4B CUL4A RAD51AP1 BRIP1 ERCC6 POLR2A NFRKB REV3L GEN1	1.35e-06	301	52	9	MM15433
Pathway	REACTOME_DNA_REPAIR	CUL4B CUL4A RAD51AP1 BRIP1 ERCC6 POLR2A NFRKB REV3L GEN1	3.02e-06	332	52	9	M15434
Pathway	REACTOME_FORMATION_OF_TC_NER_PRE_INCISION_COMPLEX	CUL4B CUL4A ERCC6 POLR2A	3.62e-05	51	52	4	M27599
Pathway	REACTOME_FORMATION_OF_TC_NER_PRE_INCISION_COMPLEX	CUL4B CUL4A ERCC6 POLR2A	3.62e-05	51	52	4	MM15315
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	NCOA2 KDM5B KMT5B ASH1L JADE1 BRWD1	4.26e-05	175	52	6	MM14941
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A ERCC6 POLR2A NFRKB	4.69e-05	108	52	5	M7927
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A ERCC6 POLR2A NFRKB	4.69e-05	108	52	5	MM15304
Pathway	WP_DNA_REPAIR_PATHWAYS_FULL_NETWORK	CUL4B CUL4A BRIP1 ERCC6 REV3L	7.76e-05	120	52	5	M40049
Pathway	REACTOME_DUAL_INCISION_IN_TC_NER	CUL4B CUL4A ERCC6 POLR2A	8.35e-05	63	52	4	MM15317
Pathway	REACTOME_DUAL_INCISION_IN_TC_NER	CUL4B CUL4A ERCC6 POLR2A	8.35e-05	63	52	4	M27601
Pathway	REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER	CUL4B CUL4A ERCC6 POLR2A	1.65e-04	75	52	4	MM15316
Pathway	REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER	CUL4B CUL4A ERCC6 POLR2A	1.74e-04	76	52	4	M27600
Pathway	KEGG_MEDICUS_REFERENCE_TRANSCRIPTION_COUPLED_NER	CUL4A ERCC6 POLR2A	1.98e-04	31	52	3	M47825
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	RAD51AP1 BRIP1 GEN1	2.85e-04	35	52	3	MM15293
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	RAD51AP1 BRIP1 GEN1	3.37e-04	37	52	3	M27583
Pathway	REACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER	CUL4B CUL4A NFRKB	3.65e-04	38	52	3	M27592
Pathway	REACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER	CUL4B CUL4A NFRKB	3.65e-04	38	52	3	MM15301
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	NCOA2 KDM5B KMT5B ASH1L JADE1 BRWD1	4.72e-04	272	52	6	M29619
Pathway	KEGG_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A ERCC6	5.64e-04	44	52	3	M18937
Pathway	WP_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A ERCC6	5.64e-04	44	52	3	M39847
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION	ERCC6 UBTF TTF1	6.85e-04	47	52	3	M1095
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION	ERCC6 UBTF TTF1	6.85e-04	47	52	3	MM15428
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_VPR_TO_CDC25_CELL_CYCLE_G2M	CUL4B CUL4A	7.19e-04	11	52	2	M47573
Pathway	BIOCARTA_MYOSIN_PATHWAY	ARHGAP5 PRKCA	7.19e-04	11	52	2	M7014
Pathway	REACTOME_DNA_DAMAGE_BYPASS	CUL4B CUL4A REV3L	7.28e-04	48	52	3	M27698
Pathway	REACTOME_DNA_DAMAGE_BYPASS	CUL4B CUL4A REV3L	7.28e-04	48	52	3	MM15432
Pathway	WP_MRNA_PROCESSING	POLR2A SRPK1 PRPF8 DHX8	1.18e-03	126	52	4	M39406
Pathway	REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR	RAD51AP1 BRIP1 GEN1	1.33e-03	59	52	3	MM15283
Pubmed	Cockayne syndrome group A and ferrochelatase finely tune ribosomal gene transcription and its response to UV irradiation.	CUL4B CUL4A ERCC6 PRKCA PRPF8	3.48e-08	42	76	5	34581821
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	CUL4A BRIX1 WDR36 UBTF POLR2A SRPK1 CDC42 C8orf33 DHX8	4.80e-08	332	76	9	25693804
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NCOA2 ARHGAP5 TICRR MAP4K3 UBTF ASH1L NFRKB AKNAD1 JADE1 CDC42 GEN1 VPS13B LRRC18 BRWD1	8.54e-08	1084	76	14	11544199
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	BRIX1 TICRR ERCC6 WDR36 PHF3 UBTF RPP38 SRPK1 PRPF8 TTF1 C8orf33 DHX8	9.26e-08	759	76	12	35915203
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CUL4B CUL4A RAD51AP1 BRIP1 WDR36 PHF3 UBTF POLR2A SIMC1 NFRKB MARF1 ZDBF2 PRPF8	1.42e-07	954	76	13	36373674
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CUL4B BRIX1 WDR36 PHF3 UBTF POLR2A SRPK1 IPO4 PRPF8 TTF1 DHX8	1.78e-07	653	76	11	22586326
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	BRIX1 TICRR WDR36 RPP38 SRPK1 PRPF8 CDC42 TTF1 C8orf33	2.86e-07	410	76	9	26949251
Pubmed	Structural basis of human transcription-DNA repair coupling.	CUL4A ERCC6 POLR2A	3.49e-07	7	76	3	34526721
Pubmed	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.	CUL4B CUL4A ERCC6 POLR2A	6.33e-07	31	76	4	32355176
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	CUL4A WDR36 ANP32B UBTF POLR2A NFRKB ZDBF2 PRPF8	7.95e-07	339	76	8	30415952
Pubmed	The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.	CUL4B CUL4A POLR2A	8.34e-07	9	76	3	34233190
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	IFIH1 SNX14 ERCC6 TOPAZ1 UBTF POLR2A PTPN22 PRPF8 C8orf33	1.41e-06	497	76	9	36774506
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	CUL4B CUL4A WDR36 POLR2A BRWD1	2.66e-06	99	76	5	34161765
Pubmed	CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.	CUL4B CUL4A ERCC6	3.59e-06	14	76	3	22032989
Pubmed	Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma.	PRKCA PLCE1	4.71e-06	2	76	2	28402280
Pubmed	Association analysis of PTPN22, CTLA4 and IFIH1 genes with type 1 diabetes in Colombian families.	IFIH1 PTPN22	4.71e-06	2	76	2	25042601
Pubmed	Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.	CUL4B CUL4A	4.71e-06	2	76	2	20064923
Pubmed	Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.	CUL4B CUL4A	4.71e-06	2	76	2	27974468
Pubmed	Recruitment of the putative transcription-repair coupling factor CSB/ERCC6 to RNA polymerase II elongation complexes.	ERCC6 POLR2A	4.71e-06	2	76	2	9372911
Pubmed	CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis.	CUL4B CUL4A ERCC6	5.50e-06	16	76	3	33288900
Pubmed	KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR).	CUL4B CUL4A ERCC6	6.67e-06	17	76	3	22902626
Pubmed	New nomenclature for chromatin-modifying enzymes.	NCOA2 KDM5B KMT5B ASH1L	7.62e-06	57	76	4	18022353
Pubmed	Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.	NCOA2 BRIP1 POLR2A	9.47e-06	19	76	3	14578343
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	BRIX1 ERCC6 WDR36 POLR2A PRKCA PRPF8 CDC42	1.37e-05	358	76	7	32460013
Pubmed	A new PKCα/β/TBX3/E-cadherin pathway is involved in PLCε-regulated invasion and migration in human bladder cancer cells.	PRKCA PLCE1	1.41e-05	3	76	2	24316392
Pubmed	CUL4high Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.	CUL4B CUL4A	1.41e-05	3	76	2	34119472
Pubmed	CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.	CUL4B CUL4A	1.41e-05	3	76	2	32587774
Pubmed	Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.	CUL4B CUL4A	1.41e-05	3	76	2	17954973
Pubmed	The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.	IFIH1 PTPN22	1.41e-05	3	76	2	28553952
Pubmed	E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation.	CUL4B CUL4A	1.41e-05	3	76	2	24452595
Pubmed	Analysis of chosen polymorphisms rs2476601 a/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 a/G - TSHR in pathogenesis of autoimmune thyroid diseases in children.	IFIH1 PTPN22	1.41e-05	3	76	2	29973096
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	CUL4B BRIX1 WDR36 POLR2A PRPF8	1.66e-05	144	76	5	35681168
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	CUL4A BRIX1 PHF3 UBTF POLR2A C8orf33	1.91e-05	251	76	6	28077445
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NCOA2 ARHGAP5 KDM5B NISCH ASH1L DENND6B TLN2 REV3L DCN PRPF8 GEN1 BRWD1	2.15e-05	1285	76	12	35914814
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	BRIX1 WDR36 KMT5B UBTF POLR2A ASH1L NFRKB SRPK1	2.18e-05	533	76	8	30554943
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CUL4A BRIX1 TICRR WDR36 PHF3 UBTF POLR2A RPP38 NFRKB PRPF8 TTF1 DHX8	2.30e-05	1294	76	12	30804502
Pubmed	Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.	ERCC6 POLR2A	2.82e-05	4	76	2	28292928
Pubmed	Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.	IFIH1 PTPN22	2.82e-05	4	76	2	20033399
Pubmed	Inflammation-dependent downregulation of miR-194-5p contributes to human intervertebral disc degeneration by targeting CUL4A and CUL4B.	CUL4B CUL4A	2.82e-05	4	76	2	30945295
Pubmed	GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression.	NCOA2 KMT5B	2.82e-05	4	76	2	19074285
Pubmed	Proximity Labeling, Quantitative Proteomics, and Biochemical Studies Revealed the Molecular Mechanism for the Inhibitory Effect of Indisulam on the Proliferation of Gastric Cancer Cells.	CUL4B CUL4A	2.82e-05	4	76	2	34420308
Pubmed	The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.	ERCC6 POLR2A	2.82e-05	4	76	2	26620705
Pubmed	CRL4s: the CUL4-RING E3 ubiquitin ligases.	CUL4B CUL4A	2.82e-05	4	76	2	19818632
Pubmed	Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.	POLR2A SRPK1	2.82e-05	4	76	2	28076779
Pubmed	Interaction of protein kinase C isozymes with Rho GTPases.	PRKCA CDC42	2.82e-05	4	76	2	11284700
Pubmed	Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.	CUL4B CUL4A	2.82e-05	4	76	2	22453236
Pubmed	Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-α mRNA polysome loading.	CUL4B CUL4A	2.82e-05	4	76	2	22262661
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CUL4B CUL4A RAD51AP1 ERCC6 KMT5B POLR2A RPP38 ASH1L NFRKB REV3L BRWD1	3.00e-05	1116	76	11	31753913
Pubmed	Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.	ERCC6 POLR2A	4.69e-05	5	76	2	16246722
Pubmed	CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy.	CUL4B CUL4A	4.69e-05	5	76	2	32466489
Pubmed	Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.	CUL4B CUL4A	4.69e-05	5	76	2	24719410
Pubmed	Two novel human NUMB isoforms provide a potential link between development and cancer.	PRKCA CDC42	4.69e-05	5	76	2	21122105
Pubmed	The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.	CUL4B CUL4A	4.69e-05	5	76	2	22118460
Pubmed	Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination.	CUL4B CUL4A	4.69e-05	5	76	2	25542213
Pubmed	Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases.	KMT5B ASH1L	4.69e-05	5	76	2	28191889
Pubmed	Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival.	CUL4B CUL4A	4.69e-05	5	76	2	27142104
Pubmed	Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.	CUL4B CUL4A	4.69e-05	5	76	2	26711351
Pubmed	Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly.	CUL4B CUL4A	4.69e-05	5	76	2	34171797
Pubmed	Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation.	CUL4B CUL4A	4.69e-05	5	76	2	36056023
Pubmed	Selective degradation of splicing factor CAPERα by anticancer sulfonamides.	CUL4B CUL4A	4.69e-05	5	76	2	28437394
Pubmed	The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels.	CUL4B CUL4A	4.69e-05	5	76	2	26021757
Pubmed	Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism.	CUL4B CUL4A	4.69e-05	5	76	2	30923324
Pubmed	Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.	CUL4B CUL4A BRWD1	4.75e-05	32	76	3	16964240
Pubmed	An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.	CUL4B NFRKB JADE1 BRWD1	4.87e-05	91	76	4	20362542
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RAD51AP1 BRIP1 ERCC6 PHF3 UBTF NFRKB DHX8 BRWD1	5.53e-05	608	76	8	36089195
Pubmed	Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF).	BRIX1 WDR36 RPP38 SRPK1 C8orf33	6.38e-05	191	76	5	21907836
Pubmed	Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.	CUL4B CUL4A	7.03e-05	6	76	2	14578910
Pubmed	cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.	CUL4B CUL4A	7.03e-05	6	76	2	8681378
Pubmed	PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.	CUL4B CUL4A	7.03e-05	6	76	2	16407252
Pubmed	The BRCT domain is a phospho-protein binding domain.	BRIP1 POLR2A	7.03e-05	6	76	2	14576433
Pubmed	Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.	CUL4B CUL4A	7.03e-05	6	76	2	22606329
Pubmed	The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.	CUL4B CUL4A	7.03e-05	6	76	2	18593899
Pubmed	CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres.	CUL4B CUL4A	7.03e-05	6	76	2	25795299
Pubmed	MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival.	CUL4B CUL4A	7.03e-05	6	76	2	34251884
Pubmed	BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.	TICRR BRIP1	7.03e-05	6	76	2	30295604
Pubmed	Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.	ERCC6 UBTF	7.03e-05	6	76	2	23562818
Pubmed	Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.	KDM5B PRKCA	7.03e-05	6	76	2	20228790
Pubmed	CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.	CUL4B CUL4A	7.03e-05	6	76	2	20932471
Pubmed	XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription.	ERCC6 POLR2A	7.03e-05	6	76	2	10944529
Pubmed	Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin.	CUL4A ERCC6	7.03e-05	6	76	2	26826127
Pubmed	TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.	CUL4B CUL4A ERCC6	7.39e-05	37	76	3	29531219
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	BRIX1 BRIP1 WDR36 PHF3 POLR2A TLN2 DHX8	7.91e-05	472	76	7	38943005
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ERCC6 WDR36 PHF3 POLR2A RPP38 NFRKB SRPK1 IPO4 CDC42 TTF1 C8orf33 DHX8	9.35e-05	1497	76	12	31527615
Pubmed	Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation.	CUL4B CUL4A	9.83e-05	7	76	2	30898011
Pubmed	SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.	CUL4B CUL4A	9.83e-05	7	76	2	35320725
Pubmed	Identification of toposome, a novel multisubunit complex containing topoisomerase IIalpha.	SRPK1 PRPF8	9.83e-05	7	76	2	15034300
Pubmed	Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.	CUL4B CUL4A	9.83e-05	7	76	2	27294876
Pubmed	The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation.	ERCC6 UBTF	9.83e-05	7	76	2	23667505
Pubmed	Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy.	CUL4B CUL4A	9.83e-05	7	76	2	37024504
Pubmed	Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).	CUL4B CUL4A	9.83e-05	7	76	2	21228219
Pubmed	Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.	CUL4B CUL4A	9.83e-05	7	76	2	23297343
Pubmed	Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.	PTPN22 REV3L	9.83e-05	7	76	2	25014791
Pubmed	Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.	CUL4B CUL4A	9.83e-05	7	76	2	23555860
Pubmed	Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation.	CUL4A ERCC6	9.83e-05	7	76	2	29225035
Pubmed	Small molecule NSC1892 targets the CUL4A/4B-DDB1 interactions and causes impairment of CRL4DCAF4 E3 ligases to inhibit colorectal cancer cell growth.	CUL4B CUL4A	9.83e-05	7	76	2	32140073
Pubmed	mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase.	CUL4B CUL4A	1.31e-04	8	76	2	18235224
Pubmed	The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.	CUL4B CUL4A	1.31e-04	8	76	2	31614064
Pubmed	Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.	CUL4B CUL4A	1.31e-04	8	76	2	27580824
Pubmed	Covalent modification of all members of human cullin family proteins by NEDD8.	CUL4B CUL4A	1.31e-04	8	76	2	10597293
Pubmed	CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver.	CUL4B CUL4A	1.31e-04	8	76	2	28178526
Interaction	NUP43 interactions	CUL4A BRIP1 WDR36 UBTF RPP38 ASH1L NFRKB MARF1 ZDBF2 CCDC168 FAM199X TTF1 DHX8	4.69e-07	625	75	13	int:NUP43
Interaction	H3C1 interactions	CUL4B CUL4A BRIX1 TNRC18 BRIP1 ERCC6 ANP32B PHF3 UBTF POLR2A ASH1L PRKCA SRPK1 JADE1 IPO4	9.38e-07	901	75	15	int:H3C1
Interaction	PPIA interactions	CUL4B BRIX1 IFIH1 ZFP42 BRIP1 ERCC6 WDR36 PHF3 POLR2A SRPK1 TLN2 PRPF8 CDC42 DHX8	4.30e-06	888	75	14	int:PPIA
Interaction	CBX3 interactions	CUL4B CUL4A RAD51AP1 BRIP1 WDR36 PHF3 UBTF POLR2A NFRKB SRPK1 CDC42 DHX8	4.38e-06	646	75	12	int:CBX3
Interaction	ERCC8 interactions	CUL4B CUL4A ERCC6 POLR2A PRKCA PRPF8	6.84e-06	124	75	6	int:ERCC8
Interaction	SMC5 interactions	CUL4B CUL4A RAD51AP1 BRIP1 WDR36 PHF3 UBTF POLR2A SIMC1 NFRKB MARF1 ZDBF2 REV3L PRPF8	1.65e-05	1000	75	14	int:SMC5
Interaction	SIRT7 interactions	CUL4B CUL4A BRIX1 WDR36 PHF3 UBTF POLR2A SRPK1 IPO4 PRPF8 TTF1 DHX8	1.81e-05	744	75	12	int:SIRT7
Interaction	SNRNP40 interactions	CUL4B CUL4A BRIP1 WDR36 UBTF RPP38 NFRKB SRPK1 ZDBF2 PRPF8 DHX8	2.25e-05	637	75	11	int:SNRNP40
Interaction	H1-4 interactions	BRIX1 VWA3A TNRC18 PHF3 UBTF PRKCA SRPK1 REV3L TTF1 C8orf33 DHX8	2.95e-05	656	75	11	int:H1-4
Interaction	MAP4K2 interactions	BRIX1 MAP4K3 SRPK1 MAP4K2 C8orf33	3.23e-05	98	75	5	int:MAP4K2
Interaction	MAGEB2 interactions	BRIX1 WDR36 UBTF ASH1L SRPK1 TTF1 C8orf33 DHX8	4.59e-05	349	75	8	int:MAGEB2
Interaction	H2BC21 interactions	CUL4B CUL4A BRIX1 TICRR KDM5B PHF3 POLR2A JADE1 PRPF8 TTF1 C8orf33	5.05e-05	696	75	11	int:H2BC21
Interaction	DDX23 interactions	BRIX1 ERCC6 WDR36 PHF3 UBTF RPP38 SRPK1 PRPF8 DHX8	7.13e-05	480	75	9	int:DDX23
Cytoband	10q11.23	ERCC6 LRRC18	1.42e-03	33	77	2	10q11.23
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND2A DENND6B DENND4C	3.64e-05	25	47	3	504
GeneFamily	Mitogen-activated protein kinase kinase kinase kinases	MAP4K3 MAP4K2	6.58e-05	5	47	2	655
GeneFamily	PHD finger proteins	KDM5B PHF3 ASH1L JADE1	8.69e-05	90	47	4	88
GeneFamily	Cullins	CUL4B CUL4A	1.83e-04	8	47	2	1032
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT5B ASH1L	3.52e-03	34	47	2	487
Coexpression	OUYANG_PROSTATE_CANCER_PROGRESSION_UP	ARHGAP5 TIRAP CDC42 PLCE1	3.76e-07	21	76	4	MM1228
Coexpression	OUYANG_PROSTATE_CANCER_PROGRESSION_UP	ARHGAP5 TIRAP CDC42 PLCE1	3.76e-07	21	76	4	M15626
Coexpression	LAKE_ADULT_KIDNEY_C28_INTERSTITIUM	RERG SETBP1 PRKCA REV3L DCN	5.20e-06	86	76	5	M39247
Coexpression	GSE11386_NAIVE_VS_MEMORY_BCELL_DN	IFIH1 KDM5B KMT5B NISCH ASH1L PRKCA	6.73e-06	158	76	6	M372
Coexpression	GSE32901_TH17_EMRICHED_VS_TH17_NEG_CD4_TCELL_DN	IFIH1 CISD2 NISCH DENND6B PTPN22 DENND4C	1.17e-05	174	76	6	M8931
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL	NCOA2 IFIH1 POLR2A ASH1L ZDBF2 JADE1	2.10e-05	193	76	6	M6813
Coexpression	PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP	ARHGAP5 RAD51AP1 BRIP1 FAM199X GEN1 BRWD1	2.23e-05	195	76	6	M13736
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL	NCOA2 IFIH1 POLR2A ASH1L ZDBF2 JADE1	2.29e-05	196	76	6	MM667
Coexpression	GSE37301_MULTIPOTENT_PROGENITOR_VS_GRAN_MONO_PROGENITOR_DN	IFIH1 MAP4K3 POLR2A XDH C8orf33 PXK	2.57e-05	200	76	6	M8849
Coexpression	NAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_DN	CUL4A KDM5B CISD2 PHF3 NFRKB MARF1 ZDBF2 CDC42 DHX8 BRWD1	2.64e-05	680	76	10	M41089
Coexpression	KIM_WT1_TARGETS_DN	CUL4A NCOA2 RAD51AP1 MAP4K3 PHF3 REV3L DENND4C BRWD1	6.63e-05	471	76	8	M17859
Coexpression	NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN	RERG KDM5B KMT5B PHF3 NISCH MARF1 XDH SLCO1B3 DENND4C	1.06e-04	648	76	9	M14371
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	CUL4B ARHGAP5 RAD51AP1 TICRR CISD2 ANP32B PHF3 SETBP1 RPP38 ZDBF2 REV3L TTF1 GEN1 DHX8 BRWD1	3.30e-05	1257	76	15	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	CUL4B ARHGAP5 RAD51AP1 TICRR CISD2 ANP32B PHF3 SETBP1 RPP38 ZDBF2 REV3L TTF1 GEN1 DEUP1 DHX8 BRWD1	4.81e-05	1459	76	16	facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlas	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4	CUL4B NCOA2 RAD51AP1 DENND2A TICRR PHF3 SETBP1 SRPK1 ZDBF2 REV3L GEN1 DEUP1 DHX8 PLCE1 BRWD1	8.80e-05	1370	76	15	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAD51AP1 CCDC60 TICRR BRIP1 GHRL GEN1	1.24e-07	134	77	6	4d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	DENND2A RERG SETBP1 TLN2 CCDC102B DCN	8.83e-07	187	77	6	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	DENND2A RERG SETBP1 TLN2 CCDC102B DCN	9.11e-07	188	77	6	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	DENND2A RERG SETBP1 TLN2 CCDC102B DCN	1.06e-06	193	77	6	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A RERG SETBP1 TLN2 CCDC102B DCN	1.16e-06	196	77	6	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	368C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SLC37A1 IFIH1 TICRR ERCC6 MARF1	6.27e-06	150	77	5	c3ad5fa41eb636a5d691c0268c0f1c32cd0de658
ToppCell	368C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SLC37A1 IFIH1 TICRR ERCC6 MARF1	6.27e-06	150	77	5	78b8029e71d26f336a46274c8afef3435bf536b9
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CCDC60 ANKEF1 DTHD1 SLC9C2 DEUP1	7.36e-06	155	77	5	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CCDC60 ANKEF1 DTHD1 SLC9C2 DEUP1	7.36e-06	155	77	5	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	10x5'-bone_marrow-Lymphocytic_B-GC_B_(I)\|bone_marrow / Manually curated celltypes from each tissue	DENND2A TICRR BRIP1 CCDC168 DCN	7.83e-06	157	77	5	d4da4057917dda066da0f2aac2621fdaf1fb943b
ToppCell	LPS-antiTNF-Endothelial-Endothelial-FOXM1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAD51AP1 TICRR BRIP1 SLCO1B3 GEN1	9.39e-06	163	77	5	5285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell	Ciliated_cells-B-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	VWA3A DTHD1 SLC9C2 LRRC18 DEUP1	1.03e-05	166	77	5	4b1056aad8a99827835242b8ab0c7f2bb84471f1
ToppCell	Adult-Mesenchymal-pericyte_cell-D175\|Adult / Lineage, Cell type, age group and donor	DENND2A RERG SETBP1 CCDC102B PLCE1	1.25e-05	173	77	5	fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VWA3A RERG SETBP1 CCDC102B DCN	1.56e-05	181	77	5	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	VWA3A CCDC60 DENND6B DTHD1 SLC9C2	1.60e-05	182	77	5	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A RERG PRKCA CCDC102B PLCE1	1.64e-05	183	77	5	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A RERG PRKCA CCDC102B PLCE1	1.69e-05	184	77	5	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	DENND2A RERG SETBP1 CCDC102B PLCE1	1.69e-05	184	77	5	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	DENND2A RERG SETBP1 CCDC102B DCN	1.82e-05	187	77	5	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	NS-critical-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RAD51AP1 SLCO1B3 GEN1 DEUP1 PLCE1	1.97e-05	190	77	5	7be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	DENND2A RERG SETBP1 CCDC102B DCN	1.97e-05	190	77	5	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 KMT5B PHF3 UBTF ASH1L	2.02e-05	191	77	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RERG SETBP1 PRKCA CCDC102B DCN	2.02e-05	191	77	5	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RERG SETBP1 PRKCA CCDC102B DCN	2.02e-05	191	77	5	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 KMT5B PHF3 UBTF ASH1L	2.02e-05	191	77	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A RERG SETBP1 CCDC102B DCN	2.02e-05	191	77	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 KMT5B PHF3 UBTF ASH1L	2.02e-05	191	77	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A RERG SETBP1 CCDC102B DCN	2.07e-05	192	77	5	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	DENND2A SETBP1 TLN2 CCDC102B DCN	2.07e-05	192	77	5	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	RAD51AP1 TICRR BRIP1 PRKCA GEN1	2.12e-05	193	77	5	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	DENND2A RERG SETBP1 CCDC102B DCN	2.12e-05	193	77	5	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A SETBP1 TLN2 CCDC102B DCN	2.12e-05	193	77	5	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	DENND2A RERG SETBP1 CCDC102B DCN	2.23e-05	195	77	5	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	DENND2A RERG SETBP1 CCDC102B DCN	2.23e-05	195	77	5	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D122\|Adult / Lineage, Cell type, age group and donor	DENND2A RERG SETBP1 CCDC102B DCN	2.23e-05	195	77	5	aa0add081881d349099d12efca5cdee098038d4e
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A RERG CCDC102B DCN PLCE1	2.28e-05	196	77	5	c373465e34e2dd581247962d59e0477aae877079
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	RAD51AP1 TICRR BRIP1 CCDC102B DCN	2.28e-05	196	77	5	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	COVID-19-lung-Proliferative_fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RAD51AP1 TICRR BRIP1 CCDC102B DCN	2.28e-05	196	77	5	ca91d5e325875e7444809b80fcbd491d8899ea36
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A RERG CCDC102B DCN PLCE1	2.28e-05	196	77	5	8b5337ccf74de90e8b89a02ac00671af1de2cfff
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A RERG SETBP1 CCDC102B DCN	2.28e-05	196	77	5	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	DENND2A RERG SETBP1 CCDC102B DCN	2.40e-05	198	77	5	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	DENND2A RERG SETBP1 CCDC102B DCN	2.40e-05	198	77	5	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A RERG SETBP1 CCDC102B DCN	2.40e-05	198	77	5	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	DENND2A RERG SETBP1 CCDC102B DCN	2.46e-05	199	77	5	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	distal-mesenchymal-Pericyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DENND2A RERG CCDC102B DCN PLCE1	2.46e-05	199	77	5	000d9b5f5a48e56f0733390adb3d7270c49a4a1a
ToppCell	distal-3-mesenchymal-Pericyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DENND2A RERG CCDC102B DCN PLCE1	2.52e-05	200	77	5	911db29f254bb697610e720ba78816e2c7f57933
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A RERG SETBP1 CCDC102B DCN	2.52e-05	200	77	5	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A RERG SETBP1 CCDC102B DCN	2.52e-05	200	77	5	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CCDC60 ANKEF1 DTHD1 LRRC18 DEUP1	2.52e-05	200	77	5	4992dbf0514d674017315dbd20d91dfec0c608e9
ToppCell	critical-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RAD51AP1 CISD2 REV3L DEUP1 PLCE1	2.52e-05	200	77	5	f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A RERG SETBP1 CCDC102B DCN	2.52e-05	200	77	5	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A RERG SETBP1 CCDC102B DCN	2.52e-05	200	77	5	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Bronchial-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A RERG CCDC102B DCN PLCE1	2.52e-05	200	77	5	362706445edb33b313684efe50b1f44f5f816e67
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A RERG SETBP1 CCDC102B DCN	2.52e-05	200	77	5	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	distal-1-mesenchymal-Pericyte\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DENND2A RERG CCDC102B DCN PLCE1	2.52e-05	200	77	5	ff205afda57b9267016f0c937445da1b0266af9b
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A RERG SETBP1 CCDC102B DCN	2.52e-05	200	77	5	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A SETBP1 TLN2 CCDC102B DCN	2.52e-05	200	77	5	74e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2\|Control_saline / Treatment groups by lineage, cell group, cell type	DENND2A RERG MAP4K3 CCDC102B PLCE1	2.52e-05	200	77	5	bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCell	LPS-antiTNF-Unknown-Endothelial-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAD51AP1 TICRR CCDC102B GEN1	8.11e-05	132	77	4	02491930097b75aaeedab9e8200711b0dc610944
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-valve_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RERG ANKEF1 NHLH2 DTHD1	1.43e-04	153	77	4	1440f2716fea74e2c3eb2924eba3d63ebd08c997
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A RERG CCDC102B PLCE1	1.55e-04	156	77	4	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A RERG CCDC102B PLCE1	1.58e-04	157	77	4	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VWA3A RERG CCDC168 PLCE1	1.62e-04	158	77	4	e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VWA3A RERG CCDC168 PLCE1	1.62e-04	158	77	4	d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CCDC60 RPP38 PRKCA GCSAML	1.92e-04	165	77	4	37615622c736e43260c38016e7c9e565ac97a3e8
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CCDC60 RPP38 PRKCA GCSAML	1.92e-04	165	77	4	640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCell	nucseq-Immune-Hematopoietic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CCDC60 RPP38 PRKCA GCSAML	1.92e-04	165	77	4	f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DENND2A BRIP1 TLN2 FAM199X	1.96e-04	166	77	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DENND2A BRIP1 TLN2 FAM199X	1.96e-04	166	77	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	15-Distal-Epithelial-Multiciliated_cell\|Distal / Age, Tissue, Lineage and Cell class	VWA3A CCDC60 DTHD1 LRRC18	2.10e-04	169	77	4	425d89ab69e9f9eb3df84056676423e390cc6ab1
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	CCDC60 RPP38 PRKCA GCSAML	2.10e-04	169	77	4	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAD51AP1 TICRR BRIP1 GEN1	2.10e-04	169	77	4	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	NS-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CCDC60 SLCO1B3 DEUP1 PLCE1	2.15e-04	170	77	4	f6a0162bb690dbc19ff1cec64cb933744ad3b496
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	CCDC60 RPP38 PRKCA GCSAML	2.15e-04	170	77	4	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	normal-na-Lymphocytic_NK-natural_killer_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	TNRC18 TLN2 DTHD1 DENND4C	2.20e-04	171	77	4	d339840626211a7bf1a9eb8f14d6c9509ab05e1c
ToppCell	facs\|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLR2A MARF1 DCN MAP4K2	2.20e-04	171	77	4	c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SETBP1 PTPN22 GEN1 PXK	2.20e-04	171	77	4	a2938e56cb5749004317798dc7ac0f0c2d4d8ae0
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TICRR ANKEF1 JADE1 BRWD1	2.25e-04	172	77	4	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR BRIP1 PTPN22 GEN1	2.35e-04	174	77	4	6b362b8a934a4fe6a1dd867b7c448cb3fb3ffd6a
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAD51AP1 BRIP1 SLCO1B3 CCDC168	2.40e-04	175	77	4	d43ae33a6256606ce848247cad32d74f21b38988
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RAD51AP1 SNX14 KCNH8 MARF1	2.40e-04	175	77	4	69ed3c7c45df6bef70f5f2ff003531160bf3b32b
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	RAD51AP1 TICRR BRIP1 GEN1	2.40e-04	175	77	4	74800a10f5ff25d5414fbccb0668f92ff077d1cc
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4\|Striatum / BrainAtlas - Mouse McCarroll V32	RAD51AP1 TICRR BRIP1 GEN1	2.45e-04	176	77	4	d70fdc7bc48719776ed1e7c01118385e3a21623f
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5-P5_1\|Striatum / BrainAtlas - Mouse McCarroll V32	RAD51AP1 TICRR BRIP1 GEN1	2.45e-04	176	77	4	a84361308e5e96f3a30246cd29e109c321ee65bf
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A RERG CCDC102B PLCE1	2.56e-04	178	77	4	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERCC6 RPP38 DENND6B PTPN22	2.56e-04	178	77	4	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	VWA3A CCDC60 DTHD1 SLC9C2	2.56e-04	178	77	4	de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCell	LPS-IL1RA-Endothelial-Endothelial-FOXM1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAD51AP1 TICRR BRIP1 GEN1	2.67e-04	180	77	4	334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A RERG CCDC102B PLCE1	2.73e-04	181	77	4	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	COVID-19-Heart-Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DENND2A RERG CCDC102B PLCE1	2.73e-04	181	77	4	33cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Ciliated\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	VWA3A CCDC60 DTHD1 LRRC18	2.73e-04	181	77	4	8eed9d46d924b16f6dd1a025ff612244b02b4391
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	VWA3A CCDC60 DTHD1 SLC9C2	2.73e-04	181	77	4	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A RERG BRIP1 MAP4K3	2.73e-04	181	77	4	709e9c7a60d5f98635b99895ce30bb87a9f7376d
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	VWA3A CCDC60 DTHD1 SLC9C2	2.78e-04	182	77	4	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RERG ZFP42 DCN PLCE1	2.78e-04	182	77	4	cde8fa4f42d25545abaa9ee885b4b1e24a5a8e08
ToppCell	Adult-Mesenchymal-pericyte_cell-D122\|Adult / Lineage, Cell type, age group and donor	DENND2A RERG CCDC102B PLCE1	2.84e-04	183	77	4	fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5\|Striatum / BrainAtlas - Mouse McCarroll V32	RAD51AP1 TICRR BRIP1 ANP32B	2.84e-04	183	77	4	f20b0d71f857ac35868fd80531050ad8b6091716
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP5 NFRKB PRKCA BRWD1	2.90e-04	184	77	4	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A RERG CCDC102B PLCE1	2.90e-04	184	77	4	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VWA3A CCDC60 DTHD1 SLC9C2	2.90e-04	184	77	4	5daff849625f2f41d56615569c0ed59cd733b34c
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A	NCOA2 BRIX1 KDM5B KMT5B PHF3 RPP38 TTF1	2.74e-06	184	76	7	2321_DN
Disease	high grade glioma (is_implicated_in)	KDM5B PRKCA DCN	1.56e-04	42	73	3	DOID:3070 (is_implicated_in)
Disease	QRS complex, QRS duration	SETBP1 NHLH2 PRKCA	1.91e-04	45	73	3	EFO_0005054, EFO_0005055
Disease	Graves Disease	IFIH1 PTPN22	2.15e-04	9	73	2	C0018213
Disease	Malignant neoplasm of breast	NCOA2 BRIP1 ERCC6 NISCH ANKEF1 SETBP1 XDH PKDREJ GEN1 VPS13B	3.04e-04	1074	73	10	C0006142
Disease	JT interval	CUL4A NCOA2 BRIP1 PRKCA BRWD1	3.80e-04	248	73	5	EFO_0007885
Disease	Libman-Sacks Disease	IFIH1 PTPN22 PXK	4.07e-04	58	73	3	C0242380
Disease	Lupus Erythematosus, Systemic	IFIH1 PTPN22 PXK	7.36e-04	71	73	3	C0024141
Disease	exercise test	CCDC60 PRKCA	1.11e-03	20	73	2	EFO_0004328
Disease	urticaria	PTPN22 GCSAML	1.11e-03	20	73	2	EFO_0005531
Disease	colorectal carcinoma (is_implicated_in)	NCOA2 ERCC6	1.35e-03	22	73	2	DOID:0080199 (is_implicated_in)
Disease	serum alanine aminotransferase measurement	BRIP1 MARF1 PRKCA XDH SLCO1B3 CCDC102B PLCE1 BRWD1	1.36e-03	869	73	8	EFO_0004735
Disease	alcohol use disorder (implicated_via_orthology)	KDM5B MAP4K3 PRKCA MAP4K2	1.41e-03	195	73	4	DOID:1574 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	KMT5B SETBP1 ASH1L	1.61e-03	93	73	3	C1535926
Disease	colorectal adenocarcinoma (is_marker_for)	NCOA2 ERCC6	2.04e-03	27	73	2	DOID:0050861 (is_marker_for)
Disease	gamma-glutamyltyrosine measurement	BRIP1 ASH1L	2.04e-03	27	73	2	EFO_0021144
Disease	suicidal ideation	NCOA2 WDR36	2.35e-03	29	73	2	EFO_0004320

Protein segments in the cluster

Peptide	Gene	Start	Entry
LPRKPKTDKFQVLAK	TTF1	136	Q15361
LQAKRTKKPPKNLEN	ASH1L	91	Q9NR48
LELGLKRQKPTPKQK	C8orf33	121	Q9H7E9
PQADPKSRQKKLLKK	FAM47DP	86	A6NHR8
VQKLRKKEPKTLLPH	BRIX1	286	Q8TDN6
KLDNLPKPAENQKLK	ANKEF1	646	Q9NU02
SVSNLPKLPKLKKLE	ANP32B	56	Q92688
PKLPKLKKLELSENR	ANP32B	61	Q92688
KQNKVPRKELPHLKE	DEUP1	116	Q05D60
PKQVKLKKPSRLKTL	DENND6B	361	Q8NEG7
LEKHLRPKQKPKNSK	ERCC6	1196	Q03468
KLPEDLKNFRPAKKI	CCDC60	461	Q8IWA6
PLNKKSRTAPKELKQ	RAD51AP1	31	Q96B01
KPKNIKKNRYKDILP	PTPN22	51	Q9Y2R2
KNPKKRPTAEKLLQH	MAP4K2	256	Q12851
KNPKKRPTAEKLLQH	MAP4K3	256	Q8IVH8
KARKALQQKPKPPSK	NFRKB	671	Q6P4R8
LKKPAKPLLSKIKLR	KMT5B	441	Q4FZB7
LPKKKNKHRNLDELP	FAM199X	166	Q6PEV8
LSKNQLKELPEKMPK	DCN	136	P07585
LPKLKKLNIKRNPFP	LRRC18	166	Q8N456
LKRKQRKLKEPLPNG	KDM5B	1101	Q9UGL1
IEKLAKNKQKPITPE	CDC42	126	P60953
DKNGLLVLPKNKKRS	BRIP1	566	Q9BX63
LSDKKPTPQRVIKLK	KCTD18	366	Q6PI47
QKQILKSEKNKPLDP	SLC37A1	271	P57057
LRKLSCLGENQKKPK	GCSAML	6	Q5JQS6
PQNGRKKRKIPKLVL	DENND2A	471	Q9ULE3
QQRKESKKPPAKLQP	GHRL	36	Q9UBU3
NQLKFPVKPGDLKKR	CUL4A	721	Q13619
LKNNRLKKENKPVIP	IFIH1	466	Q9BYX4
KQLPKKPCKNLLSTL	DENND4C	506	Q5VZ89
PKNKIINKPLAIAKQ	AKNAD1	271	Q5T1N1
LKLPKHKKLINRPQS	DTHD1	651	Q6ZMT9
NLKPKRLKSQTKIIP	BRWD1	1456	Q9NSI6
VESPAKKQPKNRVKL	MARF1	1716	Q9Y4F3
KKQKRIKPKENNLPE	GEN1	466	Q17RS7
KQKLKKLPPDRVGAN	CENATAC	271	Q86UT8
KENKRLKNISPKMLP	CCDC168	611	Q8NDH2
TLKKKQSLPPQKEAL	CCDC102B	136	Q68D86
KVKSKALLKNRLLPP	IPO4	276	Q8TEX9
QLKFPVKPADLKKRI	CUL4B	876	Q13620
PTKLSKQKKQQRLEP	DHX8	1186	Q14562
LQPLKIKKLIPNPNK	RPP38	256	P78345
VKLKLIPDPKNESKQ	PRKCA	196	P17252
PSPDQLRKKVLLKNK	PLCE1	1526	Q9P212
PSQKDLQQLKKKPRI	PKDREJ	1556	Q9NTG1
RKLLPTLPPDKKLSK	NHLH2	101	Q02577
KDLIIKRIKPKPQQG	SIMC1	796	Q8NDZ2
VPKTNVKKLDPNLLK	ARHGAP5	1046	Q13017
NPLEPKNAEKLKVKI	SRPK1	481	Q96SB4
LKRKVNFNKPLITPK	JADE1	456	Q6IE81
LPLKNILDEIKKPKN	RERG	96	Q96A58
VRPFLPKKKQQKDSL	CISD2	56	Q8N5K1
KQEPVSPKKKENALL	NCOA2	731	Q15596
LNALKHRPPKAQKKR	PRPF8	456	Q6P2Q9
LKNLRLPRELKPNKK	TNRC18	1441	O15417
AQKLKDKAIKTPKRP	TICRR	1281	Q7Z2Z1
PRSTKQKEKIPKLLK	REV3L	1586	O60673
KFAEPRNKKPSVLKL	SNX14	321	Q9Y5W7
VPRLKELINISKKPK	POLR2A	1121	P24928
KNPNKPQKERKISLS	SLCO1B3	281	Q9NPD5
IDKNLLPPKKIIGKN	NISCH	66	Q9Y2I1
KPIILQQKPRKASEK	ZDBF2	2196	Q9HCK1
LKLKKPEKNLQPRQR	PHF3	661	Q92576
KPQFKIPTKLKEALR	PXK	406	Q7Z7A4
QTILKRLEPYKKKNP	XDH	1096	P47989
KQLAEFARKKPPINK	ZFP42	166	Q96MM3
RQTLLKKPKKRPNSP	TIRAP	26	P58753
RNKKLKSLENPPLKI	TOPAZ1	171	Q8N9V7
QAKLPKTQKEKRKSP	VPS13B	1516	Q7Z7G8
AKKLEQLKPRAKPKQ	TLN2	2321	Q9Y4G6
LKKLKALNNFPKAIP	SLC9C2	841	Q5TAH2
LIQNAKKSDIPEKPK	UBTF	186	P17480
KIQTTKRAKKPPKNL	SETBP1	106	Q9Y6X0
KEKPKTLQLRSQPKK	VWA3A	736	A6NCI4
LNLDVIKKKNKPKEP	WDR36	766	Q8NI36
IDPPNHNKRKEKNLK	KCNH8	781	Q96L42