Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF18 PRAMEF22 PRAMEF19	1.44e-04	55	37	3	GO:0042974
GeneOntologyMolecularFunction	protein tyrosine kinase binding	MST1 SHC2 CPNE3 CEACAM7	1.62e-04	149	37	4	GO:1990782
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF18 PRAMEF22 PRAMEF19	4.69e-04	82	37	3	GO:1990756
GeneOntologyMolecularFunction	receptor tyrosine kinase binding	MST1 SHC2 CPNE3	6.16e-04	90	37	3	GO:0030971
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF18 PRAMEF22 PRAMEF19	7.21e-04	95	37	3	GO:0140767
GeneOntologyMolecularFunction	heme binding	CYBB CYP4Z2P CYP4Z1	2.88e-03	154	37	3	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	CYBB CYP4Z2P CYP4Z1	3.44e-03	164	37	3	GO:0046906
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	CYBB TBXA2R BBS4 ILK PRAMEF18 PAF1 SPHK1 PRAMEF22 PRAMEF19 ERVFC1-1 SKOR2 CEACAM7	4.50e-06	1483	36	12	GO:0048646
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF18 PRAMEF22 PRAMEF19	8.50e-05	47	38	3	GO:0031462
GeneOntologyCellularComponent	secretory vesicle	CYBB TBXA2R AP2M1 PRAMEF18 SPHK1 PRAMEF22 PRAMEF19 GAA CPNE3	3.12e-04	1246	38	9	GO:0099503
GeneOntologyCellularComponent	secretory granule	CYBB TBXA2R AP2M1 PRAMEF18 PRAMEF22 PRAMEF19 GAA CPNE3	3.97e-04	1014	38	8	GO:0030141
GeneOntologyCellularComponent	motile cilium	BBS4 PRAMEF18 DNAH5 PRAMEF22 PRAMEF19	4.35e-04	355	38	5	GO:0031514
GeneOntologyCellularComponent	acrosomal vesicle	TBXA2R PRAMEF18 PRAMEF22 PRAMEF19	5.20e-04	206	38	4	GO:0001669
MousePheno	increased urine nitrite level	CYBB SLC14A2	1.33e-05	3	30	2	MP:0011741
MousePheno	small kidney	ILK PRAMEF18 DNAH5 SLC14A2 SPHK1 PRAMEF22 PRAMEF19	2.54e-05	425	30	7	MP:0002989
MousePheno	abnormal urine nitrite level	CYBB SLC14A2	4.43e-05	5	30	2	MP:0011740
MousePheno	abnormal jejunum morphology	PRAMEF18 PRAMEF22 PRAMEF19	9.00e-05	41	30	3	MP:0004002
MousePheno	abnormal pancreas morphology	TMED6 PRAMEF18 DHTKD1 DNAH5 PRAMEF22 PRAMEF19	1.09e-04	367	30	6	MP:0001944
MousePheno	abnormal spermatogonia proliferation	PRAMEF18 PRAMEF22 PRAMEF19	1.36e-04	47	30	3	MP:0002685
MousePheno	abnormal renal plasma flow rate	CYBB SLC14A2	1.59e-04	9	30	2	MP:0005524
MousePheno	abnormal stomach morphology	CYBB PRAMEF18 DNAH5 PRAMEF22 PRAMEF19	1.67e-04	248	30	5	MP:0000470
MousePheno	increased abdominal adipose tissue amount	BBS4 CYP4Z1	2.90e-04	12	30	2	MP:0020411
MousePheno	abnormal duodenum morphology	PRAMEF18 PRAMEF22 PRAMEF19	3.40e-04	64	30	3	MP:0003271
MousePheno	abnormal kidney morphology	CYBB TNFRSF13B BBS4 ILK PRAMEF18 DNAH5 SLC14A2 SPHK1 PRAMEF22 PRAMEF19	3.64e-04	1363	30	10	MP:0002135
Domain	PRAME_family	PRAMEF18 PRAMEF22 PRAMEF19	6.24e-06	19	36	3	IPR026271
Domain	VWFD	ZAN MUC4	4.26e-04	16	36	2	PS51233
Domain	VWD	ZAN MUC4	4.26e-04	16	36	2	SM00216
Domain	VWF_type-D	ZAN MUC4	4.26e-04	16	36	2	IPR001846
Domain	VWD	ZAN MUC4	4.26e-04	16	36	2	PF00094
Domain	PID	DAB1 SHC2	1.32e-03	28	36	2	PF00640
Domain	PID	DAB1 SHC2	1.73e-03	32	36	2	PS01179
Domain	PTB	DAB1 SHC2	2.69e-03	40	36	2	SM00462
Domain	PTB/PI_dom	DAB1 SHC2	2.83e-03	41	36	2	IPR006020
Pubmed	Duplication and positive selection among hominin-specific PRAME genes.	PRAMEF18 PRAMEF22 PRAMEF19	1.20e-08	5	38	3	16159394
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF18 PRAMEF22 PRAMEF19	8.10e-07	17	38	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF18 PRAMEF22 PRAMEF19	8.10e-07	17	38	3	37781892
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF18 PRAMEF22 PRAMEF19	9.71e-07	18	38	3	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF18 PRAMEF22 PRAMEF19	9.71e-07	18	38	3	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF18 PRAMEF22 PRAMEF19	9.71e-07	18	38	3	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF18 PRAMEF22 PRAMEF19	9.71e-07	18	38	3	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF18 PRAMEF22 PRAMEF19	9.71e-07	18	38	3	39181896
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF18 PRAMEF22 PRAMEF19	1.15e-06	19	38	3	28604677
Pubmed	The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.	CYP4Z2P CYP4Z1	1.16e-06	2	38	2	25701119
Pubmed	The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.	CYP4Z2P CYP4Z1	1.16e-06	2	38	2	28236635
Pubmed	Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.	CYP4Z2P CYP4Z1	1.16e-06	2	38	2	15059886
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF18 PRAMEF22 PRAMEF19	1.35e-06	20	38	3	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF18 PRAMEF22 PRAMEF19	1.35e-06	20	38	3	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF18 PRAMEF22 PRAMEF19	1.35e-06	20	38	3	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF18 PRAMEF22 PRAMEF19	1.83e-06	22	38	3	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF18 PRAMEF22 PRAMEF19	2.10e-06	23	38	3	19480014
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF18 PRAMEF22 PRAMEF19	2.72e-06	25	38	3	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF18 PRAMEF22 PRAMEF19	2.72e-06	25	38	3	12620990
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF18 PRAMEF22 PRAMEF19	3.07e-06	26	38	3	18500982
Pubmed	The expansion of the PRAME gene family in Eutheria.	PRAMEF18 PRAMEF19	3.48e-06	3	38	2	21347312
Pubmed	Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.	CYP4Z2P CYP4Z1	3.48e-06	3	38	2	30832689
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF18 PRAMEF22 PRAMEF19	3.87e-06	28	38	3	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF18 PRAMEF22 PRAMEF19	4.79e-06	30	38	3	38786026
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF18 PRAMEF22 PRAMEF19	5.84e-06	32	38	3	37889087
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF18 PRAMEF22 PRAMEF19	7.69e-06	35	38	3	19389355
Pubmed	Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins.	CYBB SPHK1	1.16e-05	5	38	2	23933064
Pubmed	Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.	SLC14A2 KLHDC8B SKOR2	1.77e-05	46	38	3	21102462
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF18 PRAMEF22 PRAMEF19	1.77e-05	46	38	3	17287250
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF18 PRAMEF22 PRAMEF19	2.28e-05	50	38	3	31806660
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF18 PRAMEF22 PRAMEF19	3.56e-05	58	38	3	31598710
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF18 PRAMEF22 PRAMEF19	3.75e-05	59	38	3	11279525
Pubmed	Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum.	DAB1 SKOR2	5.20e-05	10	38	2	20809939
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	CYBB PRAMEF18 ZAN PRAMEF22 PRAMEF19 CEACAM7	8.43e-05	674	38	6	37196079
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	ZC3HC1 PAF1 DHTKD1 GAA FLAD1	8.97e-05	419	38	5	33001583
Pubmed	Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.	TNFRSF13B DHTKD1 MUC4	1.55e-04	95	38	3	24029230
Pubmed	In vivo validation of late-onset Alzheimer's disease genetic risk factors.	SHC2 CEACAM7	3.43e-04	25	38	2	38687251
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	MST1 ZC3HC1 CSMD1 PRAMEF18 TMC3 PRAMEF22 PRAMEF19	3.48e-04	1242	38	7	30973865
Pubmed	The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells.	DAB1 SKOR2	4.32e-04	28	38	2	24491816
Pubmed	Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints.	TBXA2R SHC2	6.76e-04	35	38	2	10984455
Cytoband	1p36.21	PRAMEF18 PRAMEF22 PRAMEF19	2.01e-05	63	38	3	1p36.21
Cytoband	1p33	CYP4Z2P CYP4Z1	3.90e-04	35	38	2	1p33
Cytoband	Ensembl 112 genes in cytogenetic band chr1p33	CYP4Z2P CYP4Z1	1.18e-03	61	38	2	chr1p33
GeneFamily	PRAME family	PRAMEF18 PRAMEF22 PRAMEF19	4.08e-06	24	24	3	686
GeneFamily	Cytochrome P450 family 4	CYP4Z2P CYP4Z1	1.03e-03	36	24	2	1003
Coexpression	MORI_SMALL_PRE_BII_LYMPHOCYTE_UP	PRAMEF18 POLM PRAMEF22 PRAMEF19	9.87e-06	98	36	4	MM592
Coexpression	KINNEY_DNMT1_METHYLATION_TARGETS	PRAMEF18 PRAMEF22 PRAMEF19	1.38e-05	34	36	3	MM955
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED	PRAMEF18 PRAMEF22 PRAMEF19	6.62e-05	57	36	3	MM1262
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB1 TNFRSF13B TMED6 DNAH5	7.98e-06	154	37	4	1e32969bee810adaf2d560f0824a16227df513d8
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB1 TMED6 CSMD1 DNAH5	1.10e-05	167	37	4	cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB1 TMED6 CSMD1 DNAH5	1.15e-05	169	37	4	30141f76e9bfc2b4586429857c72dbc85ba65cc9
Drug	Ki4032	TBXA2R PAF1	6.88e-06	3	35	2	CID000126397
Drug	DETCA	CYBB TBXA2R PAF1	7.48e-06	25	35	3	CID000151422
Drug	4-hydroxytryptamine	TBXA2R PAF1	2.29e-05	5	35	2	CID000011297
Drug	5-aminotryptamine	TBXA2R PAF1	3.43e-05	6	35	2	CID003083677
Disease	10-undecenoate 11:1n1 measurement	CYP4Z2P CYP4Z1	2.24e-05	7	31	2	EFO_0021099
Disease	monoclonal gammopathy	TNFRSF13B CSMD1 SLC14A2	2.37e-05	53	31	3	EFO_0000203
Disease	Alzheimer disease, visuospatial impairment	CSMD1 SLC14A2	9.64e-05	14	31	2	EFO_0009752, MONDO_0004975
Disease	lateral orbital frontal cortex volume measurement	DAB1 SLC14A2	2.91e-04	24	31	2	EFO_0010312
Disease	age at menarche	ZC3HC1 CSMD1 SLC14A2 KLHDC8B SKOR2	3.58e-04	594	31	5	EFO_0004703
Disease	nicotine withdrawal measurement	CSMD1 SLC14A2	3.69e-04	27	31	2	EFO_0009362
Disease	Strabismus	CSMD1 DNAH5	4.26e-04	29	31	2	HP_0000486
Disease	cerebrospinal fluid clusterin measurement	CSMD1 SLC14A2	6.22e-04	35	31	2	EFO_0007657
Disease	hepatocyte growth factor-like protein measurement	MST1 KLHDC8B	7.33e-04	38	31	2	EFO_0008154
Disease	systemic lupus erythematosus (implicated_via_orthology)	CYBB TNFRSF13B	9.39e-04	43	31	2	DOID:9074 (implicated_via_orthology)
Disease	heart rate variability measurement, response to antipsychotic drug	CSMD1 SLC14A2	1.07e-03	46	31	2	EFO_0008003, GO_0097332
Disease	Ulcerative Colitis	MST1 SPHK1	2.00e-03	63	31	2	C0009324
Disease	susceptibility to hepatitis A infection measurement	DAB1 SHC2	2.33e-03	68	31	2	EFO_0008415

Protein segments in the cluster

Peptide	Gene	Start	Entry
YPCAVPLWVGPFTMF	CYP4Z2P	76	Q8N1L4
VPESPPLWNNIGMCF	BBS4	266	Q96RK4
MPGTVRRWNYPSPLC	CSMD1	1956	Q96PZ7
MFPAFGFGAQIPPQW	CPNE3	341	O75131
PMCTPIFWEPPAASL	ARHGEF15	56	O94989
MGSPSACPYRVCIPW	CEACAM7	1	Q14002
PQNMGPWSFVSPRFE	DHTKD1	866	Q96HY7
GPLSPAWMPAYACQR	POLM	131	Q9NP87
VGCATYRPPQPAWMF	MUC4	4671	Q99102
MLTSTPAPPRGYFWC	ERVFC1-1	346	P60608
VQAWPFPCLPLGSLM	PRAMEF18	56	Q5VWM3
WARPPISMNFEVPFA	AP2M1	381	Q96CW1
PVFPDFKMWINPCAQ	PAF1	206	Q8N7H5
PWPTVAGQFPPAAFM	DAB1	386	O75553
CPGRMYAPAWVAPEA	ILK	346	Q13418
MLRATAPCWFPPGYP	REXO1L1P	1	Q8IX06
SKMLRATAPCWFPPG	REXO1L1P	91	Q8IX06
QMGQPWCFFPPSYPS	GAA	121	P10253
ECPIPQFAGNPPMTW	CYBB	256	P04839
GRAFAWQVFPPMPTC	KLHDC8B	6	Q8IXV7
WQVFPPMPTCRVYGT	KLHDC8B	11	Q8IXV7
PWCFTLRPGMRAAFC	MST1	341	P26927
FSPTDPGWPAFMRIN	FLAD1	501	Q8NFF5
RPHCFWMTGFFNPQG	DNAH5	4476	Q8TE73
MSQSFQFPVPWEKCP	SLC6A16	211	Q9GZN6
IWMGAFFSPCLPAFN	TMC3	571	Q7Z5M5
VQAWPFPCLPLGSLM	PRAMEF19	56	Q5SWL8
VMVQAWPFPCLPLGS	PRAMEF22	56	A3QJZ6
YPCAVPLWVGPFTMF	CYP4Z1	76	Q86W10
LNSPPSFVCWSRGFM	AUP1	116	Q9Y679
CFWPDSPSPDRFGML	ZC3HC1	156	Q86WB0
APTTFCALLPRMPQW	SHC2	21	P98077
MPNPFPNNFARSWPC	TEX52	226	A6NCN8
IMIPPGGTECFWQFA	TMED6	46	Q8WW62
DAFYPPFCMFWPPRT	SKOR2	461	Q2VWA4
FPQGLWTGVAMRSCP	TNFRSF13B	21	O14836
PNYFWMVSGCVEPPP	SPHK1	356	Q9NYA1
MWPNGSSLGPCFRPT	TBXA2R	1	P21731
TWMLGASGFPPRCPS	nan	96	Q6ZVU0
MLSVFGLPPCTWPFC	SLC14A2	851	Q15849
AWRNRTFCPMRCPPG	ZAN	1801	Q9Y493