Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

HCN1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.34e-12261238GO:0005248
GeneOntologyMolecularFunctionsodium channel activity

HCN1 GRIK4 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.79e-11521239GO:0005272
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

RHCG CACNA1A CACNA1E ABCC1 HCN1 SLC13A3 GRIK4 SLC15A3 SLC1A1 SLC1A3 SLC1A6 RYR3 SLC41A2 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A SLC26A11 ABCC10

3.36e-1175812324GO:0015318
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

HCN1 SLC13A3 GRIK4 SLC1A1 SLC1A3 SLC1A6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

4.57e-1117112313GO:0015081
GeneOntologyMolecularFunctiontransmembrane transporter activity

RHCG CACNA1A LRRC8C CACNA1E ABCC1 HCN1 SLC13A3 GRIK4 SLC15A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 RYR3 SFXN1 SLC41A2 CLCNKB ANO6 SCN1A SCN2A SLC35D3 SCN3A SCN5A SCN8A SCN9A SCN10A SLC26A11 ABCC10

9.85e-11118012329GO:0022857
GeneOntologyMolecularFunctiontransporter activity

RHCG CACNA1A LRRC8C CACNA1E ABCC1 HCN1 SLC13A3 GRIK4 SLC15A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 RYR3 SFXN1 SLC41A2 TMEM184A CLCNKB ANO6 SCN1A SCN2A SLC35D3 SCN3A SCN5A SCN8A SCN9A SCN10A SLC26A11 ABCC10

1.64e-10128912330GO:0005215
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1A LRRC8C CACNA1E HCN1 SLC13A3 GRIK4 SLC15A3 SLC1A1 SLC1A3 SLC1A6 RYR3 SFXN1 SLC41A2 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A SLC26A11

5.11e-1079312323GO:0015075
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1A LRRC8C CACNA1E HCN1 GRIK4 SLC1A1 RYR3 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A SLC26A11

3.31e-0945912317GO:0005216
GeneOntologyMolecularFunctionchannel activity

RHCG CACNA1A LRRC8C CACNA1E HCN1 GRIK4 SLC1A1 RYR3 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A SLC26A11

3.69e-0952512318GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

RHCG CACNA1A LRRC8C CACNA1E HCN1 GRIK4 SLC1A1 RYR3 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A SLC26A11

3.80e-0952612318GO:0022803
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1A CACNA1E HCN1 SLC13A3 GRIK4 SLC1A1 SLC1A3 SLC1A6 RYR3 SLC41A2 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

4.02e-0946512317GO:0046873
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

RHCG CACNA1A CACNA1E HCN1 SLC13A3 GRIK4 SLC15A3 SLC1A1 SLC1A3 SLC1A6 RYR3 SLC41A2 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

9.72e-0962712319GO:0022890
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A SCN8A SCN9A

1.56e-08141235GO:0031402
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1A CACNA1E HCN1 SLC13A3 GRIK4 SLC15A3 SLC1A1 SLC1A3 SLC1A6 RYR3 SLC41A2 ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.43e-0866412319GO:0008324
GeneOntologyMolecularFunctionacidic amino acid transmembrane transporter activity

SLC13A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6

1.18e-07201235GO:0015172
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1A CACNA1E HCN1 GRIK4 RYR3 ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.03e-0734312313GO:0005261
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A SCN8A SCN9A

4.85e-07261235GO:0031420
GeneOntologyMolecularFunctionL-glutamate transmembrane transporter activity

SLC1A1 SLC7A11 SLC1A3 SLC1A6

1.78e-06151234GO:0005313
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

ABCC1 SLC13A3 GRIK4 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1 SLC35D3 SLC26A11

2.02e-0629312311GO:0008514
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

ABCC1 SLC13A3 SLC1A1 SLC7A11 SLC26A11 ABCC10

2.03e-06611236GO:1901682
GeneOntologyMolecularFunctionhigh-affinity L-glutamate transmembrane transporter activity

SLC1A1 SLC1A3 SLC1A6

2.26e-0651233GO:0005314
GeneOntologyMolecularFunctionglutamate:sodium symporter activity

SLC1A1 SLC1A3 SLC1A6

2.26e-0651233GO:0015501
GeneOntologyMolecularFunctionoligopeptide transmembrane transporter activity

ABCC1 SLC13A3 SLC15A3 SLCO1B1

2.36e-06161234GO:0035673
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC13A3 GRIK4 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

3.91e-061051237GO:0015171
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC13A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

4.99e-06711236GO:0015179
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

ABCC1 SLC13A3 GRIK4 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

5.51e-062071239GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

ABCC1 SLC13A3 GRIK4 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

5.73e-062081239GO:0005342
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1A CACNA1E HCN1 CLCNKB ANO6 SCN1A SCN2A SCN10A

1.72e-051821238GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1A CACNA1E HCN1 CLCNKB ANO6 SCN1A SCN2A SCN10A

1.86e-051841238GO:0022832
GeneOntologyMolecularFunctionL-aspartate transmembrane transporter activity

SLC13A3 SLC1A1 SLC1A6

2.65e-05101233GO:0015183
GeneOntologyMolecularFunctiongated channel activity

CACNA1A CACNA1E HCN1 GRIK4 RYR3 CLCNKB ANO6 SCN1A SCN2A SCN10A

4.23e-0533412310GO:0022836
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC13A3 SLC1A1 SLC1A3 SLC1A6

6.19e-05351234GO:0005343
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5D16 OR10A2 CALCR OR5D14 ADGRB2 MR1 GRIK4 PTCH1 LGR5 AR ADCYAP1R1 PGR TAS2R9 OR10A4 PTPRO PTCH2 OR52E5 OR4C12 CCR7 OR6T1 OR10A5

7.62e-05135312321GO:0004888
GeneOntologyMolecularFunctioncalmodulin binding

CACNA1A MYO5B UBR4 RYR3 IQGAP1 SCN2A SCN3A SCN5A

9.07e-052301238GO:0005516
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC13A3 SLC15A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SLC35D3 SLC26A11

9.20e-052961239GO:0015291
GeneOntologyMolecularFunctionC4-dicarboxylate transmembrane transporter activity

SLC13A3 SLC1A1 SLC1A6

9.83e-05151233GO:0015556
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5D16 OR10A2 CALCR OR5D14 ADGRB2 LGR5 AR ADCYAP1R1 PGR TAS2R9 OR10A4 OR52E5 OR4C12 CCR7 OR6T1 OR10A5

1.06e-0488412316GO:0004930
GeneOntologyMolecularFunctionhedgehog receptor activity

PTCH1 PTCH2

1.12e-0431232GO:0008158
GeneOntologyMolecularFunctionneutral L-amino acid transmembrane transporter activity

SLC1A1 SLC1A3 SLC1A6 SFXN1

1.16e-04411234GO:0015175
GeneOntologyMolecularFunctionamide transmembrane transporter activity

ABCC1 SLC13A3 SLC15A3 SLCO1B1

1.28e-04421234GO:0042887
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A SCN10A

1.46e-04171233GO:0099508
GeneOntologyMolecularFunctionoxidoreductase activity, acting on metal ions

HEPH STEAP1B STEAP1

1.74e-04181233GO:0016722
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCC1 SLC13A3 SLC15A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SLC35D3 SLC26A11 ABCC10

1.79e-0447712311GO:0022804
GeneOntologyMolecularFunctionsmoothened binding

PTCH1 PTCH2

2.24e-0441232GO:0005119
GeneOntologyMolecularFunctionhedgehog family protein binding

PTCH1 PTCH2

2.24e-0441232GO:0097108
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

LRRC8C SLC1A1 SLC1A6 CLCNKB ANO6 SLC26A11

3.48e-041511236GO:0008509
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC1A1 SLC1A3 SLC1A6

3.69e-04231233GO:0005283
GeneOntologyMolecularFunctionferric-chelate reductase (NADPH) activity

STEAP1B STEAP1

3.72e-0451232GO:0052851
GeneOntologyMolecularFunctionferric-chelate reductase activity

STEAP1B STEAP1

3.72e-0451232GO:0000293
GeneOntologyMolecularFunctioncupric reductase (NADH) activity

STEAP1B STEAP1

3.72e-0451232GO:0008823
GeneOntologyMolecularFunctionhormone binding

CALCR AR ADCYAP1R1 PGR SERPINA7

4.42e-041031235GO:0042562
GeneOntologyMolecularFunctionmonoatomic anion channel activity

LRRC8C SLC1A1 CLCNKB ANO6 SLC26A11

4.42e-041031235GO:0005253
GeneOntologyMolecularFunctioncalcium-dependent phospholipid binding

CPNE2 CPNE8 CPNE5 CPNE1

5.12e-04601234GO:0005544
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity involved in cardiac muscle cell action potential

SCN5A SCN10A

5.55e-0461232GO:0086006
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

ABCC1 SLC1A1 CLCNKB ANO6 SLC26A11 ABCC10

6.72e-041711236GO:0015103
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC1A1 SLC1A3 SLC1A6

7.41e-04291233GO:0005416
GeneOntologyMolecularFunctionglutathione transmembrane transporter activity

ABCC1 SLC13A3

7.75e-0471232GO:0034634
GeneOntologyMolecularFunctionoxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

STEAP1B STEAP1

7.75e-0471232GO:0016723
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC13A3 SLC15A3 SLC1A1 SLC1A3 SLC1A6

8.53e-041191235GO:0015294
GeneOntologyMolecularFunctiondicarboxylic acid transmembrane transporter activity

SLC13A3 SLC1A1 SLC1A6

9.04e-04311233GO:0005310
GeneOntologyMolecularFunctionABC-type glutathione S-conjugate transporter activity

ABCC1 ABCC10

1.03e-0381232GO:0015431
GeneOntologyMolecularFunctionmodified amino acid transmembrane transporter activity

ABCC1 SLC13A3 SLC7A11

1.09e-03331233GO:0072349
GeneOntologyMolecularFunctionubiquitin protein ligase binding

MAGEA1 MAGEA2 MAGEA3 SCAMP3 SMG5 GLMN ERLIN2 SCN5A

1.16e-033371238GO:0031625
GeneOntologyMolecularFunctiontripeptide transmembrane transporter activity

ABCC1 SLC13A3

1.32e-0391232GO:0042937
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1E

1.32e-0391232GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1E

1.32e-0391232GO:0099626
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC13A3 SLC1A1 SLC1A3 SLC1A6

1.58e-03811234GO:0015370
GeneOntologyMolecularFunctionATPase-coupled inorganic anion transmembrane transporter activity

ABCC1 ABCC10

1.64e-03101232GO:0043225
GeneOntologyMolecularFunctionubiquitin-like protein ligase binding

MAGEA1 MAGEA2 MAGEA3 SCAMP3 SMG5 GLMN ERLIN2 SCN5A

1.70e-033581238GO:0044389
GeneOntologyMolecularFunctionestrogen response element binding

AR PGR

2.00e-03111232GO:0034056
GeneOntologyMolecularFunctionsulfur amino acid transmembrane transporter activity

SLC1A1 SLC7A11

2.00e-03111232GO:0000099
GeneOntologyMolecularFunctionvoltage-gated chloride channel activity

CLCNKB ANO6

2.00e-03111232GO:0005247
GeneOntologyMolecularFunctionhistone deacetylase binding

MAGEA1 MAGEA2 MAGEA3 SMG5 HDAC2

2.18e-031471235GO:0042826
GeneOntologyMolecularFunctionsymporter activity

SLC13A3 SLC15A3 SLC1A1 SLC1A3 SLC1A6

2.38e-031501235GO:0015293
GeneOntologyMolecularFunctionglutamate binding

SLC1A1 SLC1A3

3.26e-03141232GO:0016595
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1E

3.26e-03141232GO:0008331
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCC1 ABCC10

3.75e-03151232GO:0008559
GeneOntologyMolecularFunctionvoltage-gated monoatomic anion channel activity

CLCNKB ANO6

4.82e-03171232GO:0008308
GeneOntologyMolecularFunctionolfactory receptor activity

OR5D16 OR10A2 OR5D14 OR10A4 OR52E5 OR4C12 OR6T1 OR10A5

5.26e-034311238GO:0004984
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC1A1 CLCNKB ANO6 SLC26A11

7.49e-031251234GO:0015108
GeneOntologyMolecularFunctionlipid binding

CPNE2 SESTD1 CPNE8 HCN1 GBP1 PTCH1 CPNE5 AR PGR IQGAP1 ERLIN2 CADPS CPNE1

7.90e-0398812313GO:0008289
GeneOntologyMolecularFunction3',5'-cyclic-AMP phosphodiesterase activity

PDE6C PDE6B

8.02e-03221232GO:0004115
GeneOntologyMolecularFunctionankyrin binding

RHCG SCN5A

8.75e-03231232GO:0030506
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

CACNA1A LRRC8C CACNA1E ABCC1 SESTD1 HCN1 SLC13A3 GRIK4 SLC15A3 SLC1A1 SLC1A3 ADCYAP1R1 RYR3 SFXN1 SLC41A2 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A CCR7 STEAP1B SLC26A11 ABCC10 STEAP1

1.46e-11111512429GO:0034220
GeneOntologyBiologicalProcessmonoatomic ion transport

CACNA1A LRRC8C CACNA1E ABCC1 SESTD1 HCN1 SLC13A3 GRIK4 SLC15A3 SLCO1B1 SLC1A1 SLC1A3 SLC1A6 HEPH ADCYAP1R1 RYR3 SFXN1 SLC41A2 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A CCR7 STEAP1B SLC26A11 ABCC10 STEAP1

1.84e-11137412432GO:0006811
GeneOntologyBiologicalProcesstransmission of nerve impulse

CACNA1A CACNA1E HCN1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.44e-0911212410GO:0019226
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

RHCG CACNA1A CACNA1E SESTD1 HCN1 SLC13A3 SLC15A3 SLC1A1 SLC1A3 ADCYAP1R1 RYR3 SLC41A2 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A CCR7 STEAP1B SLC26A11 STEAP1

1.52e-09101712425GO:0098660
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.73e-09361247GO:0086010
GeneOntologyBiologicalProcessneuronal action potential

HCN1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

3.99e-09631248GO:0019228
GeneOntologyBiologicalProcessmetal ion transport

CACNA1A CACNA1E SESTD1 HCN1 SLC13A3 SLC1A1 SLC1A3 HEPH ADCYAP1R1 RYR3 SFXN1 SLC41A2 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A CCR7 STEAP1B STEAP1

5.46e-09100012424GO:0030001
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

RHCG CACNA1A CACNA1E SESTD1 HCN1 SLC13A3 SLC15A3 SLC1A1 SLC1A3 ADCYAP1R1 RYR3 SLC41A2 ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A CCR7 STEAP1B STEAP1

5.80e-0992212423GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transport

CACNA1A CACNA1E SESTD1 HCN1 SLC13A3 SLC15A3 SLC1A1 SLC1A3 HEPH ADCYAP1R1 RYR3 SFXN1 SLC41A2 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A CCR7 STEAP1B STEAP1

2.02e-08115712425GO:0006812
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA1A CACNA1E SESTD1 HCN1 SLC13A3 SLC15A3 SLC1A1 SLC1A3 ADCYAP1R1 RYR3 SLC41A2 ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A CCR7 STEAP1B STEAP1

4.22e-0894212422GO:0098655
GeneOntologyBiologicalProcessmembrane depolarization

CACNA1A HCN1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

4.91e-081211249GO:0051899
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

8.95e-08621247GO:0086002
GeneOntologyBiologicalProcessaspartate transmembrane transport

LRRC8C SLC13A3 SLC1A1 SLC1A3 SLC1A6

1.76e-07221245GO:0015810
GeneOntologyBiologicalProcessoligopeptide transport

ABCC1 SLC13A3 SLC15A3 SLCO1B1 SLC7A11

2.23e-07231245GO:0006857
GeneOntologyBiologicalProcesscirculatory system process

TBXAS1 CACNA1E ABCC1 RAP1GDS1 SLC13A3 SLC1A1 SLC1A3 AR PTPRO SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A TJP3 VEGFB

4.01e-0773312418GO:0003013
GeneOntologyBiologicalProcesssodium ion transmembrane transport

HCN1 SLC13A3 ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

5.26e-0720812410GO:0035725
GeneOntologyBiologicalProcessC4-dicarboxylate transport

LRRC8C SLC13A3 SLC1A1 SLC1A3 SLC1A6

7.66e-07291245GO:0015740
GeneOntologyBiologicalProcesssodium ion transport

HCN1 SLC13A3 CLCNKB ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

8.66e-0727512411GO:0006814
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

9.39e-07871247GO:0086001
GeneOntologyBiologicalProcessmulticellular organismal response to stress

CACNA1A CACNA1E HCN1 SLC1A1 ADCYAP1R1 SCN3A SCN9A SCN10A

9.44e-071261248GO:0033555
GeneOntologyBiologicalProcesscellular response to calcium ion

CPNE2 CPNE8 CPNE5 RYR3 IQGAP1 SCN5A CPNE1

1.01e-06881247GO:0071277
GeneOntologyBiologicalProcessbehavioral response to pain

CACNA1A CACNA1E SCN3A SCN9A SCN10A

1.28e-06321245GO:0048266
GeneOntologyBiologicalProcessimport across plasma membrane

CACNA1A LRRC8C CACNA1E ABCC1 SLC15A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SCN5A

1.32e-0623012410GO:0098739
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.48e-06931247GO:0086003
GeneOntologyBiologicalProcesssulfur compound transport

LRRC8C ABCC1 SLC13A3 SLC1A1 SLC7A11 SLC26A11

2.58e-06651246GO:0072348
GeneOntologyBiologicalProcessheart process

CACNA1E RAP1GDS1 SLC1A1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A VEGFB

2.69e-0630912411GO:0003015
GeneOntologyBiologicalProcessoligopeptide transmembrane transport

ABCC1 SLC13A3 SLC15A3 SLC7A11

2.79e-06171244GO:0035672
GeneOntologyBiologicalProcesstransepithelial transport

RHCG ABCC1 SLC1A1 SLC1A3 CLCNKB

3.10e-06381245GO:0070633
GeneOntologyBiologicalProcessactin filament-based movement

MYO5B SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

4.06e-061531248GO:0030048
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

LRRC8C ABCC1 SLC1A1 SLC1A3 CLCNKB ANO6 SLC26A11 ABCC10

4.06e-061531248GO:0098656
GeneOntologyBiologicalProcessL-aspartate import across plasma membrane

SLC1A1 SLC1A3 SLC1A6

4.19e-0661243GO:0140009
GeneOntologyBiologicalProcessL-glutamate import across plasma membrane

SLC1A1 SLC7A11 SLC1A3 SLC1A6

4.50e-06191244GO:0098712
GeneOntologyBiologicalProcessresponse to calcium ion

CPNE2 CPNE8 HCN1 CPNE5 RYR3 IQGAP1 SCN5A CPNE1

5.92e-061611248GO:0051592
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

LRRC8C ABCC1 SLC13A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

6.48e-061631248GO:1905039
GeneOntologyBiologicalProcessstriated muscle contraction

RYR3 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A VEGFB

6.67e-062171249GO:0006941
GeneOntologyBiologicalProcesscarboxylic acid transport

CACNA1A LRRC8C ABCC1 SLC13A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1 SLC26A11 ABCC10

6.95e-0641012412GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

CACNA1A LRRC8C ABCC1 SLC13A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1 SLC26A11 ABCC10

7.30e-0641212412GO:0015849
GeneOntologyBiologicalProcessorganic acid transmembrane transport

LRRC8C ABCC1 SLC13A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

7.75e-061671248GO:1903825
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A VEGFB

7.75e-061671248GO:0060048
GeneOntologyBiologicalProcessamino acid transmembrane transport

LRRC8C SLC13A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

8.12e-061201247GO:0003333
GeneOntologyBiologicalProcessdicarboxylic acid transport

LRRC8C SLC13A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SLC26A11

8.12e-061201247GO:0006835
GeneOntologyBiologicalProcessblood circulation

TBXAS1 CACNA1E RAP1GDS1 SLC1A1 AR PTPRO SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A TJP3 VEGFB

8.21e-0664812415GO:0008015
GeneOntologyBiologicalProcessglutathione transmembrane transport

ABCC1 SLC13A3 SLC7A11

1.16e-0581243GO:0034775
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.18e-051271247GO:0070252
GeneOntologyBiologicalProcessheart contraction

CACNA1E SLC1A1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A VEGFB

1.30e-0529812410GO:0060047
GeneOntologyBiologicalProcessresponse to pain

CACNA1A CACNA1E SCN3A SCN9A SCN10A

1.36e-05511245GO:0048265
GeneOntologyBiologicalProcessorganic anion transport

CACNA1A LRRC8C ABCC1 SLC13A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1 SLC35D3 SLC26A11 ABCC10

1.39e-0551512413GO:0015711
GeneOntologyBiologicalProcessmonoatomic anion transport

LRRC8C ABCC1 SLC1A1 SLC1A3 CLCNKB ANO6 SLC26A11 ABCC10

1.51e-051831248GO:0006820
GeneOntologyBiologicalProcessamino acid transport

CACNA1A LRRC8C SLC13A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

2.39e-051951248GO:0006865
GeneOntologyBiologicalProcesstripeptide transmembrane transport

ABCC1 SLC13A3 SLC7A11

2.47e-05101243GO:0035443
GeneOntologyBiologicalProcessaction potential

HCN1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.97e-052011248GO:0001508
GeneOntologyBiologicalProcessneutral amino acid transport

SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

3.04e-05601245GO:0015804
GeneOntologyBiologicalProcessglutathione transport

ABCC1 SLC13A3 SLC7A11

3.38e-05111243GO:0034635
GeneOntologyBiologicalProcessL-aspartate transmembrane transport

SLC1A1 SLC1A3 SLC1A6

3.38e-05111243GO:0070778
GeneOntologyBiologicalProcessiron ion transport

HEPH SFXN1 SLC41A2 STEAP1B STEAP1

5.19e-05671245GO:0006826
GeneOntologyBiologicalProcesscellular response to metal ion

CPNE2 CPNE8 CPNE5 SLC1A1 RYR3 IQGAP1 SCN5A CPNE1

5.45e-052191248GO:0071248
GeneOntologyBiologicalProcessL-glutamate transmembrane transport

SLC1A1 SLC7A11 SLC1A3 SLC1A6

5.64e-05351244GO:0015813
GeneOntologyBiologicalProcesstripeptide transport

ABCC1 SLC13A3 SLC7A11

5.80e-05131243GO:0042939
GeneOntologyBiologicalProcesstransition metal ion transport

SLC1A1 HEPH SFXN1 SLC41A2 STEAP1B STEAP1

6.25e-051131246GO:0000041
GeneOntologyBiologicalProcesssensory perception

OR5D16 CACNA1E OR10A2 PDE6C PDE6B OR5D14 BTBD9 SLC1A3 TAS2R9 OR10A4 SCN1A SCN8A SCN9A SCN10A OR52E5 OR4C12 OR6T1 OR10A5

7.34e-05107212418GO:0007600
GeneOntologyBiologicalProcessbehavior

CACNA1A CACNA1E HCN1 BTBD9 SLC1A1 SLC7A11 SLC1A3 AR PGR SCN1A SCN2A SCN3A SCN8A SCN9A SCN10A HDAC2

8.84e-0589112416GO:0007610
GeneOntologyBiologicalProcesstertiary branching involved in mammary gland duct morphogenesis

AR PGR

1.07e-0431242GO:0060748
GeneOntologyBiologicalProcessdetection of stimulus

OR5D16 OR10A2 PDE6C PDE6B OR5D14 TAS2R9 OR10A4 SCN1A SCN9A SCN10A OR52E5 OR4C12 OR6T1 OR10A5

1.14e-0472212414GO:0051606
GeneOntologyBiologicalProcessmuscle system process

RAP1GDS1 AR RYR3 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A HDAC2 VEGFB

1.15e-0454712412GO:0003012
GeneOntologyBiologicalProcessnegative regulation of smoothened signaling pathway

SALL3 PTCH1 RFX4 PTCH2

1.17e-04421244GO:0045879
GeneOntologyBiologicalProcessregulation of membrane potential

CACNA1A HCN1 GRIK4 SLC1A6 ANO6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.41e-0455912412GO:0042391
GeneOntologyBiologicalProcessmuscle contraction

RAP1GDS1 RYR3 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A VEGFB

1.54e-0440012410GO:0006936
GeneOntologyBiologicalProcessL-glutamate import

SLC1A1 SLC7A11 SLC1A3 SLC1A6

1.67e-04461244GO:0051938
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5D16 OR10A2 OR5D14 TAS2R9 OR10A4 SCN1A SCN9A SCN10A OR52E5 OR4C12 OR6T1 OR10A5

2.05e-0458212412GO:0050906
GeneOntologyBiologicalProcessregulation of sulfur amino acid metabolic process

CACNA1A SLC7A11

2.13e-0441242GO:0031335
GeneOntologyBiologicalProcesscopper ion transport

HEPH STEAP1B STEAP1

2.24e-04201243GO:0006825
GeneOntologyBiologicalProcessadult behavior

CACNA1A BTBD9 SLC1A1 SLC7A11 SCN1A SCN8A HDAC2

2.30e-042031247GO:0030534
GeneOntologyBiologicalProcessiron ion import across cell outer membrane

STEAP1B STEAP1

3.54e-0451242GO:0098706
GeneOntologyBiologicalProcessoligopeptide import across plasma membrane

SLC15A3 SLC7A11

3.54e-0451242GO:0140205
GeneOntologyBiologicalProcessdipeptide import across plasma membrane

SLC15A3 SLC7A11

3.54e-0451242GO:0140206
GeneOntologyBiologicalProcesscell differentiation involved in kidney development

PTCH1 IQGAP1 LIF PTPRO

3.84e-04571244GO:0061005
GeneOntologyBiologicalProcessamino acid import across plasma membrane

SLC1A1 SLC7A11 SLC1A3 SLC1A6

4.11e-04581244GO:0089718
GeneOntologyBiologicalProcessL-amino acid transport

SLC1A1 SLC7A11 SLC1A3 SLC1A6 SFXN1

4.93e-041081245GO:0015807
GeneOntologyBiologicalProcessresponse to amyloid-beta

CACNA1A ABCC1 CALCR HDAC2

4.98e-04611244GO:1904645
GeneOntologyBiologicalProcessD-aspartate import across plasma membrane

SLC1A1 SLC1A3

5.29e-0461242GO:0070779
GeneOntologyBiologicalProcessD-aspartate transmembrane transport

SLC1A1 SLC1A3

5.29e-0461242GO:0070777
GeneOntologyBiologicalProcessintracellular glutamate homeostasis

SLC1A1 SLC7A11

5.29e-0461242GO:0090461
GeneOntologyBiologicalProcessepidermal cell fate specification

PTCH1 PTCH2

5.29e-0461242GO:0009957
GeneOntologyBiologicalProcesschloride transmembrane transport

SLC1A1 SLC1A3 CLCNKB ANO6 SLC26A11

5.82e-041121245GO:1902476
GeneOntologyBiologicalProcessleukotriene transport

ABCC1 ABCC10

7.38e-0471242GO:0071716
GeneOntologyBiologicalProcessbundle of His cell action potential

SCN5A SCN10A

7.38e-0471242GO:0086043
GeneOntologyBiologicalProcessbundle of His cell to Purkinje myocyte signaling

SCN5A SCN10A

7.38e-0471242GO:0086028
GeneOntologyBiologicalProcessmammary gland branching involved in pregnancy

AR PGR

7.38e-0471242GO:0060745
GeneOntologyBiologicalProcessepithelial cell differentiation

RHCG IPO7 HRNR PTCH1 SPAG6 SLC7A11 AR PGR IQGAP1 LIF PTPRO PTCH2 HDAC2 TJP3

7.47e-0487012414GO:0030855
GeneOntologyBiologicalProcessresponse to cocaine

SLC1A1 SLC1A3 PGR HDAC2

8.86e-04711244GO:0042220
GeneOntologyBiologicalProcessresponse to metal ion

CPNE2 CPNE8 HCN1 CPNE5 SLC1A1 RYR3 IQGAP1 SCN5A CPNE1

9.17e-044151249GO:0010038
GeneOntologyBiologicalProcessregulation of presynaptic membrane potential

GRIK4 SCN1A SCN10A

9.26e-04321243GO:0099505
GeneOntologyBiologicalProcessresponse to alkaloid

SLC1A1 SLC1A3 RYR3 PGR HDAC2

9.56e-041251245GO:0043279
GeneOntologyBiologicalProcessD-amino acid transport

SLC1A1 SLC1A3

9.80e-0481242GO:0042940
GeneOntologyBiologicalProcessdipeptide transport

SLC15A3 SLC7A11

9.80e-0481242GO:0042938
GeneOntologyBiologicalProcessdipeptide transmembrane transport

SLC15A3 SLC7A11

9.80e-0481242GO:0035442
GeneOntologyBiologicalProcesschloride transport

SLC1A1 SLC1A3 CLCNKB ANO6 SLC26A11

1.06e-031281245GO:0006821
GeneOntologyBiologicalProcesscopper ion import

STEAP1B STEAP1

1.26e-0391242GO:0015677
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

SLC1A1 SLC1A3 CLCNKB ANO6 SLC26A11

1.30e-031341245GO:0098661
GeneOntologyBiologicalProcesspositive regulation of epithelial cell differentiation

IPO7 PTCH1 LIF PTCH2

1.52e-03821244GO:0030858
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

4.52e-12171267GO:0001518
GeneOntologyCellularComponentsodium channel complex

GRIK4 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

5.37e-12291268GO:0034706
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1A LRRC8C CACNA1E SESTD1 HCN1 GRIK4 RYR3 CLCNKB ANO6 SCN1A SCN2A SCN3A LRRTM4 SCN5A SCN8A SCN9A SCN10A

1.27e-1037812617GO:0034702
GeneOntologyCellularComponentcation channel complex

CACNA1A CACNA1E SESTD1 HCN1 GRIK4 RYR3 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.83e-0923512613GO:0034703
GeneOntologyCellularComponenttransmembrane transporter complex

CACNA1A LRRC8C CACNA1E SESTD1 HCN1 GRIK4 RYR3 CLCNKB ANO6 SCN1A SCN2A SCN3A LRRTM4 SCN5A SCN8A SCN9A SCN10A

1.70e-0852312617GO:1902495
GeneOntologyCellularComponenttransporter complex

CACNA1A LRRC8C CACNA1E SESTD1 HCN1 GRIK4 RYR3 CLCNKB ANO6 SCN1A SCN2A SCN3A LRRTM4 SCN5A SCN8A SCN9A SCN10A

3.54e-0855012617GO:1990351
GeneOntologyCellularComponentaxon

CALCR AZIN2 HCN1 GRIK4 PTCH1 SLC1A1 AR PGR IQGAP1 PTPRO SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A DYNC1H1

6.64e-0689112618GO:0030424
GeneOntologyCellularComponentpresynaptic membrane

CACNA1A CACNA1E LRFN1 HCN1 GRIK4 SLC1A6 SCN1A SCN2A SCN8A SCN10A

7.08e-0627712610GO:0042734
GeneOntologyCellularComponentsynaptic membrane

CACNA1A CACNA1E LRFN1 HCN1 GRIK4 SLC1A6 PTPRO ANO6 SYDE2 SCN1A SCN2A LRRTM4 SCN8A SCN10A

1.15e-0558312614GO:0097060
GeneOntologyCellularComponentbasolateral plasma membrane

RHCG ABCC1 HCN1 SLC13A3 SLCO1B1 SLC1A3 HEPH IQGAP1 SLC26A11 ABCC10

2.47e-0532012610GO:0016323
GeneOntologyCellularComponentmembrane protein complex

CACNA1A LRRC8C CACNA1E SESTD1 CALCR HCN1 MR1 GRIK4 SLC1A3 SLC1A6 RYR3 CLCNKB AP1G1 ANO6 AP5Z1 SCN1A SCN2A SCN3A LRRTM4 SCN5A SCN8A SCN9A SCN10A

2.83e-05149812623GO:0098796
GeneOntologyCellularComponentbasal plasma membrane

RHCG ABCC1 HCN1 SLC13A3 SLCO1B1 SLC1A3 HEPH IQGAP1 SLC26A11 ABCC10

5.78e-0535412610GO:0009925
GeneOntologyCellularComponentpresynapse

CACNA1A CACNA1E LRFN1 HCN1 SCAMP1 GRIK4 SLC1A1 SLC1A6 PGR AP1G1 CADPS SCN1A SCN2A SLC35D3 SCN8A SCN10A

8.60e-0588612616GO:0098793
GeneOntologyCellularComponentbasal part of cell

RHCG ABCC1 HCN1 SLC13A3 SLCO1B1 SLC1A3 HEPH IQGAP1 SLC26A11 ABCC10

9.95e-0537812610GO:0045178
GeneOntologyCellularComponentneuronal cell body

CACNA1A CACNA1E CALCR MYO5B AZIN2 HCN1 GRIK4 CPNE5 SLC1A1 SLC1A3 PGR SCN1A SCN3A SCN8A DYNC1H1

1.54e-0483512615GO:0043025
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A SCN8A

2.26e-04201263GO:0033268
GeneOntologyCellularComponentplasma membrane protein complex

CACNA1A CACNA1E CALCR HCN1 MR1 GRIK4 SCN1A SCN2A SCN3A LRRTM4 SCN5A SCN8A SCN9A SCN10A

2.78e-0478512614GO:0098797
GeneOntologyCellularComponentsomatodendritic compartment

CACNA1A CACNA1E CALCR MYO5B AZIN2 HCN1 GRIK4 PTCH1 CPNE5 SLC1A1 SLC1A3 AR PGR PTPRO SCN1A SCN3A SCN8A DYNC1H1

4.09e-04122812618GO:0036477
GeneOntologyCellularComponentperikaryon

CACNA1A CACNA1E AZIN2 GRIK4 CPNE5 SLC1A1 PGR

4.13e-042231267GO:0043204
GeneOntologyCellularComponentcell body

CACNA1A CACNA1E CALCR MYO5B AZIN2 HCN1 GRIK4 CPNE5 SLC1A1 SLC1A3 PGR SCN1A SCN3A SCN8A DYNC1H1

4.79e-0492912615GO:0044297
GeneOntologyCellularComponentaxonemal central apparatus

SPAG6 SPAG17

5.32e-0461262GO:1990716
GeneOntologyCellularComponentmanchette

SPAG6 SPAG17 DYNC1H1

6.27e-04281263GO:0002177
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN2A SCN8A

6.97e-04291263GO:0043194
GeneOntologyCellularComponentpostsynaptic membrane

CACNA1A CACNA1E LRFN1 HCN1 GRIK4 SLC1A6 PTPRO LRRTM4 SCN8A

7.89e-044051269GO:0045211
GeneOntologyCellularComponentcytoplasmic vesicle membrane

MYO5B CLEC5A SCAMP1 UBR4 MR1 GBP1 SCAMP3 PTCH1 SLC15A3 SLC1A1 IQGAP1 TMEM184A AP1G1 CADPS ANO6 SLC35D3 CPNE1 STEAP1

8.48e-04130712618GO:0030659
GeneOntologyCellularComponentsecretory granule membrane

CLEC5A SCAMP1 UBR4 IQGAP1 TMEM184A CADPS ANO6 CPNE1

8.70e-043291268GO:0030667
GeneOntologyCellularComponentvesicle membrane

MYO5B CLEC5A SCAMP1 UBR4 MR1 GBP1 SCAMP3 PTCH1 SLC15A3 SLC1A1 IQGAP1 TMEM184A AP1G1 CADPS ANO6 SLC35D3 CPNE1 STEAP1

9.92e-04132512618GO:0012506
GeneOntologyCellularComponentcalcium channel complex

CACNA1A CACNA1E SESTD1 RYR3

9.93e-04731264GO:0034704
GeneOntologyCellularComponentpresynaptic active zone membrane

CACNA1A LRFN1 HCN1 SCN8A

1.27e-03781264GO:0048787
GeneOntologyCellularComponentglutamatergic synapse

CACNA1A MYO5B HCN1 ADGRB2 GRIK4 BTBD9 SLC1A6 PTPRO CADPS SCN2A LRRTM4 SCN8A SCN10A

1.32e-0381712613GO:0098978
GeneOntologyCellularComponentlateral plasma membrane

ABCC1 IQGAP1 PTPRO SCN5A

2.16e-03901264GO:0016328
GeneOntologyCellularComponentspecific granule membrane

CLEC5A SCAMP1 UBR4 ANO6

2.24e-03911264GO:0035579
GeneOntologyCellularComponentpostsynaptic density membrane

LRFN1 GRIK4 PTPRO LRRTM4 SCN8A

2.64e-031571265GO:0098839
GeneOntologyCellularComponentapical part of cell

RHCG ABCC1 MYO5B PTCH1 SLC1A1 SLC7A11 IQGAP1 PTPRO SLC26A11 TJP3

3.14e-0359212610GO:0045177
GeneOntologyCellularComponentsecretory granule

CALCR CLEC5A SCAMP1 UBR4 HRNR SPAG6 IQGAP1 TMEM184A CADPS ANO6 CPNE1 SPAG17 DYNC1H1 VEGFB

3.21e-03101412614GO:0030141
GeneOntologyCellularComponentendosome

MYO5B SCAMP1 UBR4 RNF149 MR1 SCAMP3 SLC15A3 SLC1A1 ADCYAP1R1 TMEM184A AP1G1 AP5Z1 SLC35D3 STEAP1B STEAP1

4.48e-03116712615GO:0005768
GeneOntologyCellularComponenttrans-Golgi network membrane

SCAMP1 SCAMP3 LGR5 AP1G1

4.74e-031121264GO:0032588
HumanPhenoFacial tics

CACNA1A PNPT1 SCN1A SCN2A SCN9A

6.54e-0815405HP:0011468
HumanPhenoComplex febrile seizure

CACNA1A SCN1A SCN2A SCN8A SCN9A

9.46e-0816405HP:0011172
HumanPhenoInfection-related seizure

CACNA1A HCN1 SLC13A3 ERLIN2 SCN1A SCN2A SCN3A SCN8A SCN9A

1.23e-06145409HP:0032892
HumanPhenoSeizure precipitated by febrile infection

CACNA1A HCN1 SLC13A3 ERLIN2 SCN1A SCN2A SCN3A SCN8A SCN9A

1.23e-06145409HP:0032894
HumanPhenoFebrile seizure (within the age range of 3 months to 6 years)

CACNA1A HCN1 SLC13A3 ERLIN2 SCN1A SCN2A SCN3A SCN8A SCN9A

1.23e-06145409HP:0002373
HumanPhenoFocal automatism seizure

CACNA1A SCN1A SCN2A SCN8A

1.54e-0612404HP:0032898
HumanPhenoImpulsivity

CACNA1A HCN1 PTCH1 SLC1A3 SCN1A SCN2A SCN3A SCN8A SCN9A

1.55e-06149409HP:0100710
HumanPhenoGeneralized cerebral atrophy/hypoplasia

HCN1 SCN1A SCN2A SCN9A

2.22e-0613404HP:0007058
HumanPhenoAtypical absence status epilepticus

HCN1 SCN1A SCN2A SCN9A

7.21e-0617404HP:0011151
HumanPhenoLimitation of neck motion

CACNA1A ERLIN2 SCN1A SCN2A SCN9A

7.28e-0636405HP:0005986
HumanPhenoAbnormal neck physiology

CACNA1A ERLIN2 SCN1A SCN2A SCN9A

7.28e-0636405HP:0025669
HumanPhenoDisturbance of facial expression

CACNA1A PNPT1 SCN1A SCN2A SCN9A

7.28e-0636405HP:0005324
HumanPhenoAbnormal T-wave

CACNA1A SLC1A3 CLCNKB SCN5A SCN10A

8.37e-0637405HP:0005135
HumanPhenoGeneralized non-convulsive status epilepticus without coma

HCN1 SCN1A SCN2A SCN9A

9.22e-0618404HP:0032860
HumanPhenoAbnormal ankle morphology

COL6A3 HCN1 PNPT1 ERLIN2 SCN1A SCN2A SCN9A

9.97e-06100407HP:0034673
HumanPhenoNon-convulsive status epilepticus without coma

HCN1 SCN1A SCN2A SCN9A

1.44e-0520404HP:0032671
HumanPhenoTalipes valgus

HCN1 SCN1A SCN2A SCN9A

1.77e-0521404HP:0004684
HumanPhenoStatus epilepticus

CACNA1A CACNA1E HCN1 SLC1A3 SCN1A SCN2A SCN3A SCN8A SCN9A

2.32e-05207409HP:0002133
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A SCN9A

2.45e-058403HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A SCN9A

2.45e-058403HP:0200048
HumanPhenoAtypical absence seizure

CACNA1A HCN1 SCN1A SCN2A SCN9A

2.50e-0546405HP:0007270
HumanPhenoTibial torsion

HCN1 SCN1A SCN2A SCN9A

2.59e-0523404HP:0100694
HumanPhenoEpileptic encephalopathy

CACNA1A CACNA1E HCN1 SCN1A SCN2A SCN3A SCN8A

3.13e-05119407HP:0200134
HumanPhenoClonic seizure

HCN1 SCN1A SCN2A SCN3A SCN8A SCN9A

3.34e-0581406HP:0020221
HumanPhenoFocal hemiclonic seizure

SCN1A SCN2A SCN8A SCN9A

3.66e-0525404HP:0006813
HumanPhenoFocal impaired awareness seizure

CACNA1A HCN1 SCN1A SCN2A SCN3A SCN8A SCN9A

4.53e-05126407HP:0002384
HumanPhenoFocal-onset seizure

CACNA1A HCN1 SLC1A3 POLR3A CLCNKB SCN1A SCN2A SCN3A SCN8A SCN9A DYNC1H1

4.67e-053464011HP:0007359
HumanPhenoLimited knee extension

HCN1 SCN1A SCN2A SCN9A

5.02e-0527404HP:0003066
HumanPhenoStatus epilepticus without prominent motor symptoms

HCN1 SCN1A SCN2A SCN9A

5.02e-0527404HP:0031475
HumanPhenoSimple febrile seizure

SCN1A SCN2A SCN3A SCN8A

5.02e-0527404HP:0011171
HumanPhenoAbnormal autonomic nervous system physiology

CACNA1A SLC1A3 POLR3A SCN3A SCN5A SCN9A SCN10A

5.54e-05130407HP:0012332
HumanPhenoGaze-evoked nystagmus

CACNA1A SLC1A3 POLR3A SCN1A SCN8A

6.02e-0555405HP:0000640
HumanPhenoCortical dysplasia

HCN1 SCN1A SCN2A SCN9A DYNC1H1

6.57e-0556405HP:0002539
HumanPhenoStatus epilepticus with prominent motor symptoms

CACNA1A SCN1A SCN2A SCN9A

6.72e-0529404HP:0032658
HumanPhenoLimited neck range of motion

SCN1A SCN2A SCN9A

7.09e-0511403HP:0000466
HumanPhenoProgressive gait ataxia

CACNA1A SCN1A SCN2A SCN9A

7.71e-0530404HP:0007240
HumanPhenoProgressive ataxia

CACNA1A SCN1A SCN2A SCN9A

7.71e-0530404HP:0001329
HumanPhenoEpilepsia partialis continua

SCN1A SCN2A SCN9A

9.40e-0512403HP:0012847
HumanPhenoObsessive-compulsive trait

HCN1 SCN1A SCN2A SCN9A

1.13e-0433404HP:0008770
HumanPhenoGeneralized tonic seizure

CACNA1A SCN1A SCN2A SCN8A SCN9A

1.25e-0464405HP:0010818
HumanPhenoGeneralized clonic seizure

SCN1A SCN2A SCN8A SCN9A

1.28e-0434404HP:0011169
HumanPhenoCalcaneovalgus deformity

HCN1 SCN1A SCN2A SCN9A

1.28e-0434404HP:0001848
HumanPhenoDeformed tarsal bones

HCN1 SCN1A SCN2A SCN9A

1.43e-0435404HP:0008119
HumanPhenoLimitation of knee mobility

HCN1 SCN1A SCN2A SCN9A

1.43e-0435404HP:0010501
HumanPhenoOdontogenic keratocysts of the jaw

PTCH1 PTCH2

1.79e-043402HP:0010603
HumanPhenoCardiac fibroma

PTCH1 PTCH2

1.79e-043402HP:0010617
HumanPhenoOvarian fibroma

PTCH1 PTCH2

1.79e-043402HP:0010618
HumanPhenoBridged sella turcica

PTCH1 PTCH2

1.79e-043402HP:0005449
HumanPhenoPhotosensitive tonic-clonic seizure

SCN1A SCN2A SCN9A

1.91e-0415403HP:0007207
HumanPhenoRigidity

CACNA1A HCN1 SLC1A3 SCN1A SCN2A SCN3A SCN8A SCN9A

2.05e-04214408HP:0002063
HumanPhenoHemiplegia

CACNA1A SLC1A3 SCN1A SCN5A

2.20e-0439404HP:0002301
HumanPhenoDysgenesis of the hippocampus

SCN1A SCN2A SCN9A

2.34e-0416403HP:0025101
HumanPhenoParoxysmal dyskinesia

CACNA1A SLC1A3 SCN8A

2.34e-0416403HP:0007166
HumanPhenoFocal non-motor seizure

CACNA1A SCN1A SCN2A SCN8A

2.43e-0440404HP:0032679
HumanPhenoFocal motor status epilepticus

SCN1A SCN2A SCN9A

2.83e-0417403HP:0032663
HumanPhenoFocal clonic seizure

SCN1A SCN2A SCN8A SCN9A

2.94e-0442404HP:0002266
HumanPhenoVisually-induced seizure

SCN1A SCN2A SCN9A

3.37e-0418403HP:0020216
HumanPhenoChoreoathetosis

CACNA1A SLC1A3 PNPT1 SCN1A SCN2A SCN8A

3.44e-04123406HP:0001266
HumanPhenoPlantar pits

PTCH1 PTCH2

3.57e-044402HP:0010612
HumanPhenoAlien limb phenomenon

CACNA1A SCN1A

3.57e-044402HP:0032506
HumanPhenoFocal manual automatism seizure

CACNA1A SCN1A

3.57e-044402HP:0032900
HumanPhenoFocal pedal automatism seizure

CACNA1A SCN1A

3.57e-044402HP:0032901
HumanPhenoEpisodic hemiplegia

CACNA1A SLC1A3

3.57e-044402HP:0012194
HumanPhenoDissociated sensory loss

CACNA1A SCN1A

3.57e-044402HP:0010835
HumanPhenoFocal motor seizure

CACNA1A SLC1A3 SCN1A SCN2A SCN8A SCN9A

4.83e-04131406HP:0011153
HumanPhenoHypsarrhythmia

CACNA1A CACNA1E HCN1 SCN1A SCN2A SCN3A SCN8A

5.01e-04185407HP:0002521
HumanPhenoEEG with spike-wave complexes

HCN1 SCN1A SCN2A SCN8A SCN9A

5.61e-0488405HP:0010850
HumanPhenoEEG with abnormally slow frequencies

CACNA1A HCN1 SCN1A SCN3A SCN8A

5.61e-0488405HP:0011203
HumanPhenoNeonatal electro-clinical non-motor seizure

SCN2A SCN8A

5.92e-045402HP:0032812
HumanPhenoNeonatal seizure with electrographic correlate

SCN2A SCN8A

5.92e-045402HP:0032808
HumanPhenoNeonatal electro-clinical seizure

SCN2A SCN8A

5.92e-045402HP:0032809
HumanPhenoNeonatal electro-clinical seizure with behavior arrest

SCN2A SCN8A

5.92e-045402HP:0032823
HumanPhenoSeesaw nystagmus

CACNA1A SCN1A

5.92e-045402HP:0012044
HumanPhenoFocal head nodding automatism seizure

SCN2A SCN8A

5.92e-045402HP:0032906
HumanPhenoSpontaneous pain sensation

CACNA1A SCN1A

5.92e-045402HP:0010833
HumanPhenoAllodynia

SCN9A SCN10A

5.92e-045402HP:0012533
HumanPhenoReflex seizure

SCN1A SCN2A SCN9A

6.23e-0422403HP:0020207
HumanPhenoFocal sensory seizure

CACNA1A SCN1A SCN8A

6.23e-0422403HP:0011157
HumanPhenoAbnormality of the ankle

COL6A3 HCN1 PNPT1 ERLIN2 SCN1A SCN2A SCN9A

6.27e-04192407HP:0003028
HumanPhenoEEG with multifocal slow activity

CACNA1A HCN1 SCN3A SCN8A

6.73e-0452404HP:0010844
HumanPhenoFocal tonic seizure

CACNA1A SCN2A SCN8A

7.13e-0423403HP:0011167
HumanPhenoAtonic seizure

CACNA1A HCN1 SCN1A SCN2A SCN9A

7.59e-0494405HP:0010819
HumanPhenoParesthesia

CACNA1A ERLIN2 CLCNKB SCN1A SCN9A SCN10A

7.98e-04144406HP:0003401
HumanPhenoVertigo

CACNA1A SLC1A3 CLCNKB SCN1A SCN2A SCN5A

8.58e-04146406HP:0002321
HumanPhenoSkewfoot

CACNA1A SLC1A3

8.84e-046402HP:0032649
HumanPhenoOcular flutter

CACNA1A SLC1A3

8.84e-046402HP:0031931
HumanPhenoNormal interictal EEG

SCN2A SCN8A

8.84e-046402HP:0002372
HumanPhenoPes valgus

COL6A3 SCN1A SCN2A SCN9A

8.92e-0456404HP:0008081
HumanPhenoEncephalopathy

CACNA1A CACNA1E HCN1 PNPT1 CLCNKB SCN1A SCN2A SCN3A SCN8A

9.14e-04335409HP:0001298
HumanPhenoEpileptic aura

CACNA1A SCN1A SCN8A

9.15e-0425403HP:0033348
HumanPhenoGeneralized myoclonic seizure

CACNA1A HCN1 SCN1A SCN2A SCN8A SCN9A

9.22e-04148406HP:0002123
HumanPhenoAbnormality of the calcaneus

HCN1 SCN1A SCN2A SCN9A

9.54e-0457404HP:0008364
HumanPhenoEEG with generalized epileptiform discharges

CACNA1A CACNA1E HCN1 SCN1A SCN2A SCN3A SCN8A SCN9A

9.79e-04270408HP:0011198
HumanPhenoHyporeflexia

CACNA1A RAP1GDS1 HCN1 AR PNPT1 CLCNKB SCN3A SCN8A SCN9A DYNC1H1

1.02e-034134010HP:0001265
HumanPhenoAbnormal vestibular function

CACNA1A SLC1A3 PNPT1 CLCNKB SCN1A SCN2A SCN5A

1.13e-03212407HP:0001751
HumanPhenoSpastic dysarthria

POLR3A PNPT1 ERLIN2

1.15e-0327403HP:0002464
HumanPhenoCSF pleocytosis

CACNA1A SLC13A3 SCN1A

1.15e-0327403HP:0012229
HumanPhenoGastrostomy tube feeding in infancy

RALGAPA1 PTCH1 PNPT1 SCN1A SCN3A

1.20e-03104405HP:0011471
HumanPhenoEyelid myoclonia seizure

SCN2A SCN8A

1.23e-037402HP:0032678
HumanPhenoCalcification of falx cerebri

PTCH1 PTCH2

1.23e-037402HP:0005462
MousePhenoabnormal action potential

CACNA1A HCN1 SCN1A SCN2A SCN5A SCN8A SCN9A SCN10A

5.63e-061331028MP:0005402
DomainNa_channel_asu

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

5.66e-14101247IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

5.66e-14101247IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

5.66e-14101247PF06512
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A

7.58e-1461246PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A

7.58e-1461246IPR024583
DomainChannel_four-helix_dom

CACNA1A CACNA1E SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.29e-10571249IPR027359
Domain-

CACNA1A CACNA1E SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.29e-105712491.20.120.350
DomainIon_trans_dom

CACNA1A CACNA1E HCN1 RYR3 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.55e-1011412411IPR005821
DomainIon_trans

CACNA1A CACNA1E HCN1 RYR3 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.55e-1011412411PF00520
DomainIQ_motif_EF-hand-BS

MYO5B IQGAP1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

8.40e-09901249IPR000048
DomainIQ

MYO5B IQGAP1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.13e-08931249PS50096
DomainIQ

MYO5B IQGAP1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A

6.45e-08811248SM00015
DomainCopine

CPNE2 CPNE8 CPNE5 CPNE1

2.27e-0791244PF07002
DomainCopine

CPNE2 CPNE8 CPNE5 CPNE1

2.27e-0791244IPR010734
DomainIQ

MYO5B IQGAP1 SCN1A SCN3A SCN8A SCN9A SCN10A

4.48e-07711247PF00612
DomainNA_DICARBOXYL_SYMP_1

SLC1A1 SLC1A3 SLC1A6

9.80e-0671243PS00713
DomainNA_DICARBOXYL_SYMP_2

SLC1A1 SLC1A3 SLC1A6

9.80e-0671243PS00714
DomainSDF

SLC1A1 SLC1A3 SLC1A6

9.80e-0671243PF00375
Domain-

SLC1A1 SLC1A3 SLC1A6

9.80e-06712431.10.3860.10
DomainNa-dicarboxylate_symporter

SLC1A1 SLC1A3 SLC1A6

9.80e-0671243IPR001991
DomainNa-dicarboxylate_symporter_CS

SLC1A1 SLC1A3 SLC1A6

9.80e-0671243IPR018107
DomainTM_rcpt_patched

PTCH1 PTCH2

4.37e-0521242IPR004766
DomainVWFA

CPNE2 COL6A3 CPNE8 CPNE5 CPNE1

2.16e-04821245PS50234
DomainVWA

CPNE2 COL6A3 CPNE8 CPNE5 CPNE1

2.42e-04841245SM00327
DomainMAGE_N

MAGEA1 MAGEA3 MAGEB16

3.00e-04201243SM01392
DomainMAGE_N

MAGEA1 MAGEA3 MAGEB16

4.01e-04221243PF12440
DomainMAGE_N

MAGEA1 MAGEA3 MAGEB16

4.01e-04221243IPR021072
DomainSCAMP

SCAMP1 SCAMP3

4.32e-0451242PF04144
DomainSCAMP

SCAMP1 SCAMP3

4.32e-0451242IPR007273
DomainVWF_A

CPNE2 COL6A3 CPNE8 CPNE5 CPNE1

5.17e-04991245IPR002035
DomainHormR

CALCR ADGRB2 ADCYAP1R1

5.90e-04251243SM00008
DomainC2_dom

CPNE2 CPNE8 CPNE5 CADPS SYDE2 CPNE1

7.96e-041641246IPR000008
DomainHRM

CALCR ADGRB2 ADCYAP1R1

8.29e-04281243PF02793
DomainCa_chan_IQ

CACNA1A CACNA1E

8.98e-0471242SM01062
DomainCa_chan_IQ

CACNA1A CACNA1E

8.98e-0471242PF08763
DomainVDCC_a1su_IQ

CACNA1A CACNA1E

8.98e-0471242IPR014873
DomainGPHH

CACNA1A CACNA1E

8.98e-0471242PF16905
DomainGPHH_dom

CACNA1A CACNA1E

8.98e-0471242IPR031649
DomainGAF

PDE6C PDE6B

8.98e-0471242PF01590
DomainGAF

PDE6C PDE6B

1.19e-0381242IPR003018
DomainGAF

PDE6C PDE6B

1.19e-0381242SM00065
DomainMAGE

MAGEA1 MAGEA3 MAGEB16

1.47e-03341243SM01373
Domain-

PDE6C PDE6B

1.53e-03912423.30.450.40
DomainGAF_dom-like

PDE6C PDE6B

1.53e-0391242IPR029016
DomainPtc/Disp

PTCH1 PTCH2

1.53e-0391242IPR003392
DomainPatched

PTCH1 PTCH2

1.53e-0391242PF02460
DomainMAGE

MAGEA1 MAGEA3 MAGEB16

1.74e-03361243PS50838
DomainMHD_dom

MAGEA1 MAGEA3 MAGEB16

1.74e-03361243IPR002190
DomainMAGE

MAGEA1 MAGEA3 MAGEB16

1.74e-03361243PF01454
DomainC2

CPNE2 CPNE8 CPNE5 CADPS CPNE1

1.82e-031311245PF00168
DomainVDCCAlpha1

CACNA1A CACNA1E

1.90e-03101242IPR002077
DomainARM-type_fold

RALGAPA1 RAP1GDS1 IPO7 UBR4 SPAG6 RYR3 MROH8 AP1G1

1.93e-033391248IPR016024
DomainC2

CPNE2 CPNE8 CPNE5 CADPS CPNE1

2.21e-031371245SM00239
DomainGPCR_2_extracellular_dom

CALCR ADGRB2 ADCYAP1R1

2.36e-03401243IPR001879
DomainG_PROTEIN_RECEP_F2_1

CALCR ADGRB2 ADCYAP1R1

2.36e-03401243PS00649
DomainG_PROTEIN_RECEP_F2_3

CALCR ADGRB2 ADCYAP1R1

2.36e-03401243PS50227
DomainC2

CPNE2 CPNE8 CPNE5 CADPS CPNE1

2.58e-031421245PS50004
DomainFerric_reduct

STEAP1B STEAP1

2.76e-03121242PF01794
DomainFe3_Rdtase_TM_dom

STEAP1B STEAP1

2.76e-03121242IPR013130
Domain-

CPNE2 CPNE8 CPNE5 SYDE2 CPNE1

3.09e-0314812452.60.40.150
DomainSSD

PTCH1 PTCH2

3.25e-03131242IPR000731
DomainSSD

PTCH1 PTCH2

3.25e-03131242PS50156
Domain7tm_2

CALCR ADGRB2 ADCYAP1R1

4.46e-03501243PF00002
DomainG_PROTEIN_RECEP_F2_2

CALCR ADGRB2 ADCYAP1R1

4.46e-03501243PS00650
DomainOlfact_rcpt

OR5D16 OR10A2 OR5D14 OR10A4 OR52E5 OR4C12 OR6T1 OR10A5

4.74e-033931248IPR000725
DomainG_PROTEIN_RECEP_F1_2

OR5D16 OR10A2 OR5D14 LGR5 TAS2R9 OR10A4 OR52E5 OR4C12 CCR7 OR6T1 OR10A5

6.32e-0369112411PS50262
DomainGPCR_Rhodpsn

OR5D16 OR10A2 OR5D14 LGR5 TAS2R9 OR10A4 OR52E5 OR4C12 CCR7 OR6T1 OR10A5

6.39e-0369212411IPR000276
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.45e-0931987M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.84e-0932987M27455
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

RHCG LRRC8C ABCC1 MYO5B SLC13A3 SLC15A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 HEPH RYR3 SLC41A2 ERLIN2 CLCNKB ANO6 PCSK6 SLC26A11 ABCC10

3.56e-086819820MM14985
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

RHCG LRRC8C ABCC1 MYO5B SLC13A3 SLC15A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 HEPH RYR3 SLC41A2 ERLIN2 CLCNKB ANO6 PCSK6 SLC26A11 ABCC10

1.27e-077369820M27287
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

RHCG SLC13A3 SLC15A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 HEPH SLC41A2 SLC26A11

7.76e-072389811MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

RHCG SLC13A3 SLC15A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 HEPH SLC41A2 SLC26A11

1.21e-062499811M5988
PathwayWP_DRAVET_SYNDROME

HCN1 SCN1A SCN2A SCN3A SCN8A

1.27e-0628985M45519
PathwayREACTOME_CARDIAC_CONDUCTION

RYR3 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

3.31e-06130988M27454
PathwayREACTOME_L1CAM_INTERACTIONS

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.09e-05121987M872
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

GLS2 SLC1A1 SLC1A3 SLC1A6

2.10e-0524984MM14834
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

GLS2 SLC1A1 SLC1A3 SLC1A6

2.10e-0524984M630
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A CACNA1E RYR3

5.16e-0511983M47958
PathwayWP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING

LRRC8C GLS2 GRIK4 SLC1A1 SLC1A3 SLC1A6 LIF

5.34e-05140987M42572
PathwayREACTOME_MUSCLE_CONTRACTION

RYR3 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

8.36e-05203988M5485
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC15A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SLC26A11

1.05e-04108986M823
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC15A3 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SLC26A11

1.10e-04109986MM15074
PathwayREACTOME_NEURONAL_SYSTEM

CACNA1A CACNA1E LRFN1 GLS2 HCN1 GRIK4 SLC1A1 SLC1A3 SLC1A6 LRRTM4

1.10e-043359810MM14503
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

GLS2 SLC1A1 SLC1A3 SLC1A6

4.27e-0451984M4281
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

GLS2 SLC1A1 SLC1A3 SLC1A6

4.27e-0451984MM14499
PathwayREACTOME_NEURONAL_SYSTEM

CACNA1A CACNA1E LRFN1 GLS2 HCN1 GRIK4 SLC1A1 SLC1A3 SLC1A6 LRRTM4

5.66e-044119810M735
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

CACNA1A CACNA1E GLS2 GRIK4 SLC1A1 SLC1A3 SLC1A6

6.66e-04211987MM14502
PathwayREACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION

PTCH1 PTCH2

9.82e-047982M27501
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.48e-169126716382098
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A SCN8A SCN9A SCN10A

2.00e-156126623652591
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.17e-1413126715123669
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A SCN5A SCN8A

7.18e-119126515746173
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1A CACNA1E HCN1 CLCNKB SCN1A SCN3A SCN5A SCN8A SCN9A SCN10A

9.73e-111391261016985003
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A SCN8A

1.64e-104126417537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A SCN8A

1.64e-104126435031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A SCN8A

1.64e-104126429578003
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A SCN5A SCN8A

4.47e-1012126530175250
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A SCN9A

8.19e-10512648812438
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN3A SCN5A SCN8A SCN9A

8.19e-105126422875929
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A SCN5A SCN8A

8.19e-105126417724025
Pubmed

The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.

CPNE2 CPNE8 CPNE5 CPNE1

2.04e-08912649430674
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A SCN9A

4.64e-083126319284629
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A SCN9A

4.64e-083126333895391
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

4.64e-083126323859570
Pubmed

Molecular regulation of antioxidant ability in the hippocampus of EL mice.

SLC1A1 SLC7A11 SLC1A3

4.64e-083126318621028
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

4.64e-083126312610651
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN3A SCN9A SCN10A

4.64e-083126319699781
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

4.64e-083126318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

4.64e-083126317544618
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A SCN8A

4.64e-083126332845893
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A SCN8A

4.64e-083126328518218
Pubmed

Facilitated activation of metabotropic glutamate receptors in cerebellar Purkinje cells in glutamate transporter EAAT4-deficient mice.

SLC1A1 SLC1A3 SLC1A6

4.64e-083126317727989
Pubmed

Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia.

SLC1A1 SLC1A3 SLC1A6

4.64e-083126317221839
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A SCN8A

4.64e-083126317928448
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

4.64e-083126314973256
Pubmed

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

GLS2 MYO5B SLC13A3 GRIK4 SLCO1B1 SLC1A1 SLC7A11 SLC41A2 SLC26A11

8.71e-08212126919521566
Pubmed

Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.

SLC1A1 SLC1A3 SLC1A6

1.85e-074126322424243
Pubmed

Semi-quantitative distribution of excitatory amino acid (glutamate) transporters 1-3 (EAAT1-3) and the cystine-glutamate exchanger (xCT) in the adult murine spinal cord.

SLC1A1 SLC7A11 SLC1A3

1.85e-074126332768484
Pubmed

A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.

MAGEA1 MAGEA2 MAGEA3

1.85e-07412631840703
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN1A SCN9A SCN10A

1.85e-074126322260870
Pubmed

Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter.

SLC1A1 SLC1A3 SLC1A6

1.85e-07412639379843
Pubmed

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

MAGEA1 MAGEA2 MAGEA3

1.85e-07412638113684
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

1.85e-074126335801810
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A SCN8A

1.85e-074126321156207
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

1.85e-07412638974318
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

CACNA1A CACNA1E HCN1 ADGRB2 SLC1A1 SLC1A3 ADCYAP1R1 SFXN1 SCN1A LRRTM4 SCN9A

2.86e-074051261138187761
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

4.62e-07512631679748
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

4.62e-075126324337656
Pubmed

Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells.

SLC1A1 SLC1A3 SLC1A6

4.62e-07512639129177
Pubmed

A contextual model for axonal sorting into glomeruli in the mouse olfactory system.

OR10A2 OR10A4 OR10A5

4.62e-075126315186781
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

RHCG COL6A3 RAP1GDS1 MYO5B SLC13A3 CPNE5 SLC1A1 IQGAP1 FCGBP WIZ PTPRO ANO6 SCN10A SLC26A11 DYNC1H1 SERPINA7

8.86e-0710161261619056867
Pubmed

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.

SCN8A SCN9A SCN10A

9.21e-076126316029194
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN3A SCN8A SCN10A

9.21e-076126323711479
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A SCN8A

1.61e-067126325818041
Pubmed

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.

SCN1A SCN5A SCN8A

1.61e-067126315272007
Pubmed

MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases.

MAGEA1 MAGEA2 MAGEA3

1.61e-067126322134685
Pubmed

Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters.

MAGEA1 MAGEA2 MAGEA3

1.61e-067126317634428
Pubmed

Pain without nociceptors? Nav1.7-independent pain mechanisms.

SCN3A SCN9A SCN10A

1.61e-067126324440715
Pubmed

Expression of melanoma-associated antigens in oral squamous cell carcinoma.

MAGEA1 MAGEA2 MAGEA3

1.61e-067126318197853
Pubmed

Significant determinants of mouse pain behaviour.

SCN3A SCN9A SCN10A

2.57e-068126325101983
Pubmed

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

SCN1A SCN5A SCN8A

3.84e-069126317884088
Pubmed

Genomic analysis of orthologous mouse and human olfactory receptor loci.

OR10A2 OR10A4 OR10A5

3.84e-069126311416212
Pubmed

Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

SCN3A SCN9A SCN10A

3.84e-06912638854872
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

RALGAPA1 CACNA1E SESTD1 ADGRB2 BTBD9 SLC1A3 IQGAP1 DYNC1H1

9.06e-06281126828706196
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1A LRRC8C CACNA1E UBR4 SMG5 UPF1 IQGAP1 CADPS SCN8A SCN9A

9.65e-064751261031040226
Pubmed

A high-density association screen of 155 ion transport genes for involvement with common migraine.

CACNA1E SCN5A SCN9A

9.97e-0612126318676988
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN2A SCN3A

9.97e-061212638169823
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNA1A CACNA1E SESTD1 LRFN1 HCN1 UBR4 ADGRB2 UPF1 BTBD9 SLC1A3 IQGAP1 WIZ DYNC1H1 HDAC2

1.11e-059631261428671696
Pubmed

A common genetic variant within SCN10A modulates cardiac SCN5A expression.

SCN5A SCN10A

1.30e-052126224642470
Pubmed

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells.

SLC1A3 SLC1A6

1.30e-052126229741614
Pubmed

Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice.

SLC1A1 SLC1A3

1.30e-052126215363892
Pubmed

Calcitonin/PAC1 receptor splice variants: a blind spot in migraine research.

CALCR ADCYAP1R1

1.30e-052126237543479
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

1.30e-052126220346423
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

1.30e-052126237901435
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

1.30e-052126226410685
Pubmed

Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.

PDE6C PDE6B

1.30e-052126226085644
Pubmed

VEGF-B is a potent antioxidant.

PDE6B VEGFB

1.30e-052126230249667
Pubmed

The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium.

AR PGR

1.30e-052126218511503
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

1.30e-052126210827969
Pubmed

Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1.

PDE6B HCN1

1.30e-052126235437278
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

1.30e-052126219694741
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

1.30e-052126235348308
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

1.30e-052126211245985
Pubmed

Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16.

SPAG6 SPAG17

1.30e-052126215827353
Pubmed

Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.

SCN5A SCN10A

1.30e-052126215047701
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

1.30e-052126215760941
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

1.30e-05212621317301
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

1.30e-052126223016767
Pubmed

The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains.

PTCH1 PTCH2

1.30e-052126230166346
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

1.30e-052126227153334
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

1.30e-052126224990319
Pubmed

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

SCN3A SCN9A

1.30e-052126225172946
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

1.30e-052126231439038
Pubmed

Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses.

SLC1A3 SLC1A6

1.30e-052126216177048
Pubmed

5' CpG island methylation analysis identifies the MAGE-A1 and MAGE-A3 genes as potential markers of HCC.

MAGEA1 MAGEA3

1.30e-052126216516880
Pubmed

MAGE expressions mediated by demethylation of MAGE promoters induce progression of non-small cell lung cancer.

MAGEA1 MAGEA3

1.30e-052126221273595
Pubmed

Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: an in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4.

SLC1A3 SLC1A6

1.30e-052126216647773
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

1.30e-052126231943325
Pubmed

Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues.

MAGEA1 MAGEA3

1.30e-052126217007017
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

1.30e-052126215249644
Pubmed

The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits.

SLC1A1 SLC1A6

1.30e-052126217360917
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

1.30e-052126227690330
Pubmed

Sodium channel slow inactivation interferes with open channel block.

SCN8A SCN9A

1.30e-052126227174182
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

1.30e-052126218601978
Pubmed

Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome.

SCN5A SCN10A

1.30e-052126224998131
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

1.30e-052126223965409
Pubmed

Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis.

MAGEA1 MAGEA3

1.30e-052126211691819
Pubmed

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

SCN2A SCN8A

1.30e-052126219465131
InteractionSCN11A interactions

CACNA1A SCN1A SCN5A SCN8A SCN9A SCN10A

1.61e-10151176int:SCN11A
InteractionCACNA1D interactions

CACNA1A SCN1A SCN5A SCN9A SCN10A

2.35e-07241175int:CACNA1D
InteractionSCN5A interactions

CACNA1A SCN1A SCN5A SCN8A SCN9A SCN10A

2.98e-07471176int:SCN5A
InteractionSCN10A interactions

CACNA1A SCN1A SCN5A SCN10A

3.45e-07111174int:SCN10A
InteractionSCN1A interactions

CACNA1A SCN1A SCN5A SCN9A SCN10A

6.43e-07291175int:SCN1A
InteractionNALCN interactions

CACNA1A SCN1A SCN5A SCN9A

1.03e-06141174int:NALCN
InteractionSCN9A interactions

CACNA1A SCN1A SCN5A SCN9A

5.98e-06211174int:SCN9A
InteractionSCN4B interactions

SCN1A SCN2A SCN8A

1.05e-0581173int:SCN4B
InteractionNEDD4L interactions

HCN1 PTCH1 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A CPNE1

1.76e-0532011710int:NEDD4L
InteractionSSTR3 interactions

CACNA1A CACNA1E HCN1 ADGRB2 SLC1A1 SLC1A3 ADCYAP1R1 SFXN1 SCN1A LRRTM4 SCN9A

1.84e-0539311711int:SSTR3
InteractionDIRAS3 interactions

RALGAPA1 ABCC1 CPNE8 RAP1GDS1 IPO7 SCAMP1 RNF19B SCAMP3 GLMN

2.25e-052621179int:DIRAS3
InteractionCACNA1B interactions

CACNA1A SCN1A SCN5A SCN9A

6.15e-05371174int:CACNA1B
InteractionCACNA1A interactions

CACNA1A SCN1A PCSK6 SCN5A SCN9A SCN10A

8.23e-051231176int:CACNA1A
Cytoband11p15.4

OR10A2 IPO7 OR10A4 OR52E5 OR10A5

2.38e-04200126511p15.4
Cytoband2q24

SCN3A SCN9A

4.04e-041112622q24
CytobandEnsembl 112 genes in cytogenetic band chr2q24

SCN1A SCN2A SCN3A SCN9A

4.31e-041271264chr2q24
CytobandEnsembl 112 genes in cytogenetic band chr1p22

LRRC8C GBP1 GLMN SYDE2

5.73e-041371264chr1p22
Cytoband2q24.3

SCN1A SCN2A

8.74e-041612622q24.3
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

4.56e-15910071203
GeneFamilyCopines

CPNE2 CPNE8 CPNE5 CPNE1

1.09e-0791004829
GeneFamilySolute carriers

RHCG SLC13A3 SLC15A3 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 SLC41A2 SLC35D3 SLC26A11

1.17e-0539510011752
GeneFamilyMAGE family

MAGEA1 MAGEA2 MAGEA3 MAGEB16

6.91e-054010041136
GeneFamilySecretory carrier membrane proteins

SCAMP1 SCAMP3

3.00e-0451002735
GeneFamilyProteases, serine|STEAP family

STEAP1B STEAP1

3.00e-04510021324
GeneFamilyATP binding cassette subfamily C

ABCC1 ABCC10

2.27e-03131002807
GeneFamilyOlfactory receptors, family 10

OR10A2 OR10A4 OR10A5

5.84e-03661003157
CoexpressionGSE1460_CD4_THYMOCYTE_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_UP

COL6A3 MR1 PTCH1 GLMN FCGBP AP1G1 SCN3A HDAC2

4.41e-061991228M3474
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SLC1A1 PTPRO SCN1A SCN2A SCN3A LRRTM4 SCN9A

1.06e-072001268f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SLC1A1 PTPRO SCN1A SCN2A SCN3A LRRTM4 SCN9A

1.06e-072001268cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SLC1A1 PTPRO SCN1A SCN2A SCN3A LRRTM4 SCN9A

1.06e-072001268c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SLC1A1 PTPRO SCN1A SCN2A SCN3A LRRTM4 SCN9A

1.06e-0720012684fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SLC1A1 PTPRO SCN1A SCN2A SCN3A LRRTM4 SCN9A

1.06e-072001268310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SLC1A1 PTPRO SCN1A SCN2A SCN3A LRRTM4 SCN9A

1.06e-072001268961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

CACNA1A HCN1 CADPS SCN2A SLC35D3 SCN3A SCN8A

8.89e-07182126757bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A CACNA1E ADGRB2 CPNE5 SCN1A SCN2A SCN8A

1.03e-0618612677278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A HCN1 CADPS SCN2A SLC35D3 SCN3A SCN8A

1.03e-061861267b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CACNA1E CPNE5 PGR CADPS SCN2A SCN3A SCN9A

1.10e-061881267b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A HCN1 CADPS SCN2A SLC35D3 SCN3A SCN8A

1.10e-061881267c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A CACNA1E ADGRB2 CPNE5 SCN1A SCN2A SCN8A

1.32e-061931267be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A CACNA1E ADGRB2 CPNE5 SCN1A SCN2A SCN8A

1.32e-0619312670c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A CACNA1E ADGRB2 CPNE5 SCN1A SCN2A SCN8A

1.32e-0619312678689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A HCN1 CADPS SCN1A SCN2A SCN3A SCN8A

1.56e-061981267c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A HCN1 CADPS SCN2A SLC35D3 SCN3A SCN8A

1.56e-0619812678f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A HCN1 CADPS SCN1A SCN2A SCN3A SCN8A

1.56e-0619812676d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A HCN1 CADPS SCN1A SCN2A SCN3A SCN8A

1.56e-0619812674ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A HCN1 CADPS SCN2A SLC35D3 SCN3A SCN8A

1.56e-061981267e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellTCGA-Brain|World / Sample_Type by Project: Shred V9

SALL3 GRIK4 RFX4 SLC1A3 ADCYAP1R1 SCN1A

9.02e-061701266f78e360a6a44d599ec0d207cba4704e50aa314f8
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A HCN1 CADPS SCN2A SCN3A SPAG17

1.10e-0517612662e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCellE16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCAMP1 TMEM184A CADPS SLC35D3 SCN5A SCN9A

1.17e-051781266d3a75a8082e70543b84c35d53fe77625300d19fa
ToppCellE16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCAMP1 TMEM184A CADPS SLC35D3 SCN5A SCN9A

1.17e-051781266b2cda1df801b1a1a41e3dd2808baef37765cd804
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A CALCR HCN1 CADPS SCN3A SPAG17

1.21e-0517912668ce5000088b727783a0619baa16a2cd036d21f54
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

CACNA1A GBP1 CPNE5 PNPT1 PTPRO CCR7

1.37e-051831266dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RHCG SALL3 CPNE5 CLCNKB SCN2A SCN3A

1.37e-0518312662e831a4d99c6f983793df71c0994124c943c6da9
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A MYO5B RYR3 SCN3A SCN5A CCR7

1.46e-051851266bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.46e-0518512667fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCellHealthy_donor-pDC|World / disease group, cell group and cell class (v2)

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.55e-051871266aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A HCN1 SLC1A6 CADPS SCN1A SCN8A

1.60e-0518812661efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Striatum / BrainAtlas - Mouse McCarroll V32

CACNA1E MYO5B ADGRB2 CPNE5 SCN2A SCN3A

1.60e-051881266e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A HCN1 SLC1A6 SCN1A SCN2A SCN8A

1.65e-051891266f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellControl-Myeloid-pDC|Control / Disease group, lineage and cell class

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.65e-05189126646770b99da42f11f10cfc67cea8562342d60b867
ToppCellPBMC-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.70e-051901266adffa93635da10251f28b2089fd96b189775c8b4
ToppCellPBMC-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.70e-0519012669a91bf1ea105029e6412d0d9060bca325299ce26
ToppCellPBMC-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.70e-05190126639c8ddc2639bf3e986dae11fbae61a735614b604
ToppCellPBMC-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.70e-0519012662c1c079fd411c03bc3f383aa927eea9446716960
ToppCellPBMC-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.70e-051901266a95aea3aa707fc4574810706341a5f32b3d00209
ToppCellPBMC-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.70e-05190126618dfa84c62dcf081ce9958a71e76a394ec0968e4
ToppCell15-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

CACNA1A CADPS SCN2A SLC35D3 SCN3A SCN9A

1.75e-05191126676311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SALL3 SLC13A3 RFX4 SLC7A11 SLC1A3 ADCYAP1R1

1.75e-051911266fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCellHealthy-pDC|World / disease group, cell group and cell class

AZIN2 SLC7A11 AR SLC41A2 SCN9A VEGFB

1.75e-0519112666e1d825dc33b915b95f13ccd237a552160a4be98
ToppCell11.5-Airway-Epithelial-Epithelial|Airway / Age, Tissue, Lineage and Cell class

CACNA1E ADCYAP1R1 CADPS SCN2A SCN3A SCN5A

1.80e-051921266a77d3692ff02ef7e066a9bd9e22725055a25c4d4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A HCN1 SLC1A6 SCN1A SCN2A SCN8A

1.85e-0519312665fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

RHCG COL6A3 GRIK4 PTCH1 SLC35D3 PTCH2

1.96e-051951266c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCellMonocytes-NUPR1+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

TBXAS1 CLEC5A SLC15A3 SLC1A3 PTPRO SCN9A

1.96e-0519512665e12201ce7ba912e7faa123ca200e609252ba288
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TBXAS1 CALCR CLEC5A SLC1A3 FCGBP POLQ

2.08e-0519712660a404b4494a2246d5a92299235056f0fda4d2b48
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A3 DCHS2 GRIK4 PTCH1 LGR5 LRRTM4

2.08e-05197126644673c38384453207871d3fd8e8ba9093cc06bc5
ToppCellsevere-pDC|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

HRNR SLC7A11 AR SLC41A2 SCN9A VEGFB

2.14e-05198126622da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-IN_Progenitors|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

CPNE8 SALL3 RFX4 SLC7A11 SLC1A3 VEGFB

2.14e-0519812663811d9e3e54bbe8b208c591697e43b55ab5bbf0e
ToppCellHealthy_Control-Myeloid-Macrophages-FCN1+SPP1+|Healthy_Control / Condition, Lineage, Cell class and cell subclass

SESTD1 CLEC5A RNF19B GBP1 SLC1A3 PNPT1

2.14e-051981266aa90326b82e21de37af5642df6a70a8b21af7f04
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

CACNA1A HCN1 CADPS SCN2A SCN3A SCN8A

2.26e-05200126648d801219bc771d6c7e151dc88ca4c179988de85
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SALL3 SLC1A3 HEPH GLMN

2.64e-051231265a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CALCR FCGBP WIZ SCN5A SPAG17

3.32e-051291265cbeeaa554da971ba2e4c4b82c85a1d070a45abb8
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Meis2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RHCG SALL3 LGR5 PTPRO

4.16e-056812643c5d0d35e4d1c5506a4a490e2f93e8024294207f
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Meis2-Meis2_Adamts19|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RHCG SALL3 LGR5 PTPRO

4.16e-056812643a61ea2b234829632fabede72761aa6664550e56
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SALL3 CALCR SLC1A6 FMO6P LRRTM4

4.90e-0514012657ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SALL3 CALCR SLC1A6 FMO6P LRRTM4

4.90e-0514012651a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RHCG SALL3 CALCR CLCNKB SCN3A

7.47e-05153126598670bbce4a770af244f033cdd2d54db57200ca8
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA1A SLC1A1 SCN1A SCN2A SCN3A

7.94e-05155126577fdae85d36efb776db977eb424b32487ef222e4
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_2|390C / Donor, Lineage, Cell class and subclass (all cells)

CLEC5A UBR4 SLC15A3 SLC1A3 AR

7.94e-05155126515bacd06cc2b02b13c85bb71c5b758e5ff613e80
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 RNF149 SLC15A3 SLC7A11 PTPRO

8.44e-051571265c8f516d3f5622202d3f8514f68614cd86ea3f667
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 RNF149 SLC15A3 SLC7A11 PTPRO

8.44e-0515712654862a11ab8df27d26b4f1c1785e544a2d5b6db6e
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 RNF149 SLC15A3 SLC7A11 PTPRO

8.44e-051571265a0ec1628ce29841889f1d9d4ee9422921af7b0b5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 GRIK4 LGR5 HEPH ZNF333

8.96e-051591265330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1A HCN1 GRIK4 CADPS LRRTM4

8.96e-0515912655335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 GRIK4 LGR5 HEPH ZNF333

8.96e-051591265cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SLC7A11 AR SLC41A2 SCN9A VEGFB

9.22e-05160126561f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SLC7A11 AR SLC41A2 SCN9A VEGFB

9.22e-05160126534b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 SCN1A PCSK6 SCN3A SCN5A

9.50e-051611265133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 SCN1A PCSK6 SCN3A SCN5A

9.50e-0516112659466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 SCN1A PCSK6 SCN3A SCN5A

9.50e-051611265cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCellfacs-Aorta-Heart-18m-Myeloid-professional_antigen_presenting_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF149 SLC15A3 SLC7A11 CPNE1 CCR7

9.78e-051621265a6c6b953156c2e393d6ef5c3228eae90c472dda6
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RHCG SALL3 CPNE5 CLCNKB SCN2A

9.78e-05162126536ddebe3bb172c992739353b7b049b2dde98b559
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_PP_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE8 SPAG6 SLC41A2 LRRTM4 SERPINA7

9.78e-051621265ca1014e32996f777bff021830ce9a7cf4acf58d5
ToppCelldroplet-Lung-21m-Hematologic-myeloid-neutrophil|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPNE2 CLEC5A RNF149 SLC7A11 LDHC

9.78e-051621265f24eb596653180040bfdefad9c246fc42cbfaac8
ToppCelldroplet-Lung-21m-Hematologic-myeloid-neutrophil-neutrophil|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPNE2 CLEC5A RNF149 SLC7A11 LDHC

9.78e-0516212651a953e165b7e469815294728350ec13d27c9bd9d
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 SCN1A PCSK6 SCN3A SCN5A

9.78e-05162126596c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SESTD1 CALCR RYR3 IQGAP1 SCN2A

9.78e-051621265373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1A HCN1 GRIK4 CADPS LRRTM4

1.01e-04163126519c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellfacs-Aorta-Heart-18m-Myeloid|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF149 SLC15A3 SLC7A11 CPNE1 CCR7

1.01e-041631265ae9dd2daf06ad0b78f666617f6b070ec3ecc13d8
ToppCellfacs-Aorta-Heart-18m-Myeloid-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF149 SLC15A3 SLC7A11 CPNE1 CCR7

1.01e-041631265ee94242a048fc62b85be85eca2442e13553cbfb7
ToppCelldroplet-Liver-LIVER-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 CLEC5A SLC15A3 SLC1A3 ANO6

1.04e-041641265939d4e3911fce185b986639c815de0a0389f6cfd
ToppCelldroplet-Liver-LIVER-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 CLEC5A SLC15A3 SLC1A3 ANO6

1.04e-0416412653281f2452cc6b11f3e030a3942002b9457dde6fe
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 SCN1A PCSK6 SCN3A SCN5A

1.07e-041651265347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 SCN1A PCSK6 SCN3A SCN5A

1.07e-041651265507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 SCN1A PCSK6 SCN3A SCN5A

1.07e-04165126539a25be081a5d59c7cf107a997d352793d5025fb
ToppCellBac-SEP-Myeloid-tDC|Bac-SEP / Disease, Lineage and Cell Type

AR LCLAT1 SLC41A2 MROH8 SCN9A

1.07e-0416512658728f927502e56f2768b4224e9111939d3d7815a
ToppCellfacs-Heart-LV-24m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 CLEC5A PGR FCGBP PTPRO

1.07e-04165126541707e66542ea27133043740ef9e58ab89b06607
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPNE2 SCN1A PCSK6 SCN3A SCN5A

1.07e-0416512651890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellfacs-MAT-Fat-18m-Myeloid|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 RNF149 SLC15A3 SLC7A11 PTPRO

1.10e-0416612659116be2805c34881debb999d8417e43832fcf2f2
ToppCellwk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

COL6A3 DCHS2 HRNR ADCYAP1R1 SCN8A

1.10e-04166126565dafed953b01a9830b54309af75c7a561e88336
ToppCellfacs-MAT-Fat-18m-Myeloid-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 RNF149 SLC15A3 SLC7A11 PTPRO

1.10e-0416612655c2667da79935f3d4b1edbfe7a10e7dbc2fa3ad0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1A CACNA1E SLC13A3 CADPS LRRTM4

1.13e-0416712653edb0570e583bb527165bcd8a4c25a042054043b
ToppCellfacs-GAT-Fat-24m-Myeloid-myeloid_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 RNF149 SLC15A3 SLC7A11 PTPRO

1.13e-0416712655d9ffbcb539d9c50cef9dd792ea11aa37dd2c1df
ToppCellfacs-GAT-Fat-24m-Myeloid|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 RNF149 SLC15A3 SLC7A11 PTPRO

1.13e-041671265c31e41fb76ba261ac546fac3cc2b8337e39bfa86
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

HCN1 RNF149 AR PGR SCN1A

1.13e-0416712659efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellfacs-GAT-Fat-24m-Myeloid-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 RNF149 SLC15A3 SLC7A11 PTPRO

1.13e-041671265a04d1f2413fd24ad5e9cc67312220606157fecf3
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

HCN1 RNF149 AR PGR SCN1A

1.13e-041671265904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellfacs-MAT-Fat-24m-Myeloid|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 RNF149 SLC15A3 SLC7A11 PTPRO

1.16e-0416812656514a27a54ea0f07172b3a73270250143a7b14f0
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A SCN8A SCN10A

1.25e-0861244ctd:C475726
Druglamotrigine

CACNA1A CACNA1E PTCH1 RYR3 SCN2A SCN3A SCN5A SCN9A SCN10A

1.47e-081161249CID000003878
DrugZonisamide

SCN1A SCN2A SCN3A SCN5A SCN9A

2.59e-08171245DB00909
Drugphenytoin

CACNA1A CACNA1E COL6A3 PTCH1 RYR3 SCN2A SCN3A SCN5A SCN9A SCN10A VEGFB

3.31e-0821912411CID000001775
Drugriluzole

CACNA1A CACNA1E GRIK4 SLC1A1 SLC1A3 RYR3 SCN3A SCN5A SCN9A SCN10A

4.04e-0817412410CID000005070
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN3A SCN8A SCN10A

5.77e-0881244ctd:C489827
DrugNSC7524

CACNA1A CACNA1E GRIK4 LDHC RYR3 SCN2A SCN3A SCN5A SCN9A SCN10A

6.18e-0818212410CID000005657
DrugSodium

CACNA1E SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

3.83e-07841247ctd:D012964
Drugenzacamene

CACNA1A CACNA1E GRIK4 SLC1A1 SLC1A3 SLC1A6 AR PGR

5.42e-071291248ctd:C038939
Druganthglutin

SLC1A1 SLC7A11 SLC1A3 SLC1A6

5.77e-07131244CID000125748
DrugLidocaine

SCN5A SCN9A SCN10A

6.28e-0741243DB00281
DrugAPETx2 protein, Anthopleura elegantissima

SCN2A SCN8A SCN10A

6.28e-0741243ctd:C501880
Drugsodium

HCN1 SLC13A3 GRIK4 UPF1 SLCO1B1 SLC1A1 SLC7A11 SLC1A3 LDHC SLC1A6 RYR3 PGR CLCNKB SCN2A SCN3A SCN5A SCN9A SCN10A SLC26A11

8.49e-0794412419CID000000923
Drugsipatrigine

CACNA1E SLC1A1 SLC1A3 SCN2A SCN9A

1.67e-06371245CID000060803
DrugL-Glutamic Acid

GLS2 GRIK4 SLC1A1 SLC7A11 SLC1A3 SLC1A6

1.92e-06681246DB00142
Drugbutylparaben

CACNA1A CACNA1E GRIK4 SLC1A1 SLC1A3 SLC1A6 AR PGR

2.39e-061571248ctd:C038091
DrugTetrodotoxin

SCN2A SCN3A SCN5A SCN8A SCN9A

2.50e-06401245ctd:D013779
Drugfenpropathrin

SCN2A SCN3A SCN10A

3.12e-0661243ctd:C044267
Drugtetradotoxin

CACNA1A CACNA1E HCN1 GRIK4 PTCH1 ADCYAP1R1 SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

3.99e-0642812412CID000020382
Druggabapentin

CACNA1A CACNA1E GRIK4 RYR3 SCN3A SCN5A SCN9A SCN10A

4.14e-061691248CID000003446
Drugbepridil

CACNA1A CACNA1E RYR3 SCN3A SCN5A SCN9A SCN10A

5.92e-061261247CID000002351
Drugcarbamazepine

SLC13A3 PTCH1 SLC1A1 SCN2A SCN3A SCN5A SCN9A SCN10A

6.32e-061791248CID000002554
DrugAC1L1BXF

ABCC1 GRIK4 SLC1A1 SLC7A11 SLC1A3 SLC1A6

7.11e-06851246CID000001650
Drugpotassium

RHCG CACNA1A CACNA1E GLS2 HCN1 GRIK4 PTCH1 SLC1A1 SLC7A11 SLC1A3 SLC1A6 RYR3 CLCNKB SCN2A SCN3A SCN5A SCN9A SCN10A

8.94e-06100812418CID000000813
Drugoctylmethoxycinnamate

CACNA1A CACNA1E GRIK4 SLC1A1 SLC1A3 SLC1A6 PGR

1.13e-051391247ctd:C118580
DrugMephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; PC3; HT_HG-U133A

CALCR PDE6B ADGRB2 PTCH1 SLC1A6 WIZ PTPRO SCN5A

1.27e-0519712483685_UP
DrugCGX 0596987; Up 200; 20uM; MCF7; HT_HG-U133A

COL6A3 SLC13A3 PTCH1 SPAG6 SLC7A11 SCN1A SCN5A SCN8A

1.27e-0519712486412_UP
DrugMexiletine

SCN5A SCN9A SCN10A

1.29e-0591243ctd:D008801
DrugAC1L1MOZ

SCN3A SCN5A SCN9A SCN10A

1.33e-05271244CID000031958
Drugcyfluthrin

AR SCN2A SCN3A SCN10A

1.79e-05291244ctd:C052570
Drugisradipine

CACNA1A CACNA1E RYR3 SCN3A SCN9A SCN10A

1.81e-051001246CID000003784
Drugtocainide

SCN3A SCN5A SCN9A SCN10A

2.06e-05301244CID000038945
Drugzonisamide

PTCH1 SLC1A1 SCN3A SCN9A SCN10A

2.23e-05621245CID000005734
DrugAC1L1CQC

LDHC SCN3A SCN5A SCN9A SCN10A

2.81e-05651245CID000002012
DrugHexylcaine

SCN5A SCN10A

2.94e-0521242DB00473
DrugMethyltrienolone

AR PGR

2.94e-0521242DB02998
DrugRanolazine

SCN5A SCN9A

2.94e-0521242DB00243
DrugPhenytoin

SCN1A SCN5A

2.94e-0521242DB00252
DrugAC1L1IKP

AR PGR

2.94e-0521242CID000004620
DrugRiluzole

SLC7A11 SCN5A

2.94e-0521242DB00740
Druglatoconazole

AR PGR

2.94e-0521242ctd:C072774
Drug7alpha,11beta-dimethyl-19-nortestosterone

AR PGR

2.94e-0521242ctd:C501167
Drugetoposide phosphate

AR PGR

2.94e-0521242ctd:C061400
DrugDCG-IV

CACNA1A CACNA1E SLC1A1 SLC1A3 SLC1A6

3.50e-05681245CID000115114
Drugethyldichloroarsine

ADGRB2 SLC1A1 SLC1A3 SLC1A6

3.85e-05351244CID000011711
DrugT2755

GRIK4 PTCH1 SCN3A SCN9A SCN10A

4.32e-05711245CID000005514
Drugflecainide

RYR3 SCN3A SCN5A SCN9A SCN10A

4.32e-05711245CID000003355
Drugbenzocaine

SCN2A SCN3A SCN9A SCN10A

4.82e-05371244CID000002337
Drug1, 3-diallylurea

CACNA1E ABCC1 SCN3A SCN9A SCN10A

5.27e-05741245CID000074537
Drugethosuximide

CACNA1A CACNA1E HCN1 PTCH1 RYR3

5.27e-05741245CID000003291
Drugtetrachlorodian

AR PGR SERPINA7

5.49e-05141243ctd:C041181
Drugcimetidine

ABCC1 SLC13A3 LGR5 SLCO1B1 LDHC AR ABCC10

5.73e-051791247CID000002756
Druggamma-aminobutyric acid

CACNA1A CACNA1E AZIN2 GRIK4 PTCH1 SLC1A1 SLC1A3 SLC1A6 AR RYR3 CLCNKB

5.80e-0547412411CID000000119
Drugprobenecid

ABCC1 CALCR SLC13A3 SLCO1B1 LIF ABCC10

5.84e-051231246CID000004911
DrughilE

PTCH1 SLC1A1 SLC1A3 SLC1A6 PTCH2

5.99e-05761245CID000000791
DrugLSOs

ABCC1 GRIK4 SLC1A1 SLC1A3 PGR PCSK6

6.11e-051241246CID000164701
Drugpseudococaine

SALL3 GLS2 GRIK4 SLC1A1 SLC1A3 SLC1A6 LIF SCN3A SCN5A SCN9A SCN10A CCR7

6.74e-0557012412CID000002826
Drugglutamate

CACNA1A CACNA1E GLS2 AZIN2 HCN1 SLC13A3 GRIK4 SLC1A1 SLC7A11 SLC1A3 LDHC SLC1A6 ADCYAP1R1 RYR3 CLCNKB SCN9A

6.87e-0596212416CID000000611
Drugverapamil

CACNA1A CACNA1E ABCC1 MYO5B SLCO1B1 RYR3 SCN3A SCN5A SCN9A SCN10A ABCC10

7.79e-0549012411CID000002520
Drug17alpha-estradiol

RHCG CACNA1A CACNA1E ABCC1 COL6A3 CALCR SLCO1B1 SLC7A11 LDHC AR PGR IQGAP1 CLCNKB CPNE1 CCR7 POLQ STEAP1 HDAC2 VEGFB

8.02e-05130312419CID000000450
Drugpropofol

HCN1 SLC1A1 LDHC RYR3 SCN3A SCN9A SCN10A

8.62e-051911247CID000004943
DrugDibucaine

SCN5A SCN10A

8.80e-0531242DB00527
DrugDrospirenone

AR PGR

8.80e-0531242DB01395
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN3A SCN9A

8.80e-0531242ctd:C561228
DrugLoteprednol Etabonate

AR PGR

8.80e-0531242ctd:D000069559
Drugmexrenone

AR PGR

8.80e-0531242CID003082529
Drugaramite

SESTD1 LIF

8.80e-0531242CID000008809
Drugversalide

AR PGR

8.80e-0531242ctd:C023054
Drugirilone

AR PGR

8.80e-0531242ctd:C530234
Drugcreatine

CALCR MYO5B SLC1A1 SLC1A3 LDHC SLC1A6 RYR3

9.20e-051931247CID000000586
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

ABCC1 RNF19B SMG5 SLC7A11 SLC1A3 WIZ PCSK6

9.51e-0519412476201_DN
DrugAsiaticoside [16830-15-2]; Up 200; 4.2uM; HL60; HT_HG-U133A

CACNA1A RMND5B UBR4 PTCH1 SLC15A3 LDHC PCSK6

1.01e-0419612472943_UP
DrugClemizole hydrochloride [1163-36-6]; Up 200; 11uM; MCF7; HT_HG-U133A

RALGAPA1 CACNA1A SLC13A3 SLC7A11 PGR LIF CCR7

1.08e-0419812474695_UP
Drugsulfinpyrazone

TBXAS1 ABCC1 SLC13A3 SLCO1B1 ABCC10

1.14e-04871245CID000005342
Drugpilsicainide

SCN3A SCN5A SCN9A SCN10A

1.15e-04461244CID000004820
DrugSulfabenzamide [127-71-9]; Up 200; 14.4uM; MCF7; HT_HG-U133A

RNF19B SLC13A3 PTCH1 WIZ PTPRO AP5Z1 CTSO

1.15e-0420012472814_UP
Drugcyclophorine

CACNA1A CACNA1E ABCC1 COL6A3 SLCO1B1 LDHC RYR3 PGR GLMN ABCC10

1.16e-0442612410CID000002909
Drugtribromodiphenyl ether 28

AR PGR SERPINA7

1.21e-04181243ctd:C533760
Drugsulfosalicylic acid

ABCC1 SLCO1B1 HEPH

1.21e-04181243CID000007322
DrugScorpion Venoms

SCN2A SCN3A SCN9A

1.21e-04181243ctd:D012604
DrugZidovudine

ABCC1 HCN1 MR1 GBP1 SLC13A3 CPNE5 SLC1A1 PGR SFXN1 SLC26A11 ABCC10

1.34e-0452112411ctd:D015215
Drugnorgestimate

AR PGR SERPINA7

1.43e-04191243ctd:C017576
Drugdiprafenone

SCN3A SCN9A SCN10A

1.43e-04191243CID000071249
Drug2-naphthalenesulfonate

SLC13A3 GRIK4 UPF1 PGR HDAC2

1.49e-04921245CID000008420
Drugdecamethrin

AR SCN1A SCN2A SCN3A SCN8A SCN10A

1.50e-041461246ctd:C017180
Drugmalonate

SLC13A3 GRIK4 SLC1A1 SLC1A3 SLC1A6 SCN2A SCN3A

1.51e-042091247CID000000867
DrugAC1N8N2J

GRIK4 PTCH1 SLC1A1

1.68e-04201243CID004346372
Druglaurolactam

AR PGR

1.75e-0441242ctd:C474694
DrugLevonorgestrel

AR PGR

1.75e-0441242DB00367
DrugOseltamivir

AR PGR

1.75e-0441242ctd:D053139
DrugYVN

SLC1A1 SLC1A3

1.75e-0441242CID009547990
DrugAC 110

CACNA1A CACNA1E

1.75e-0441242CID000022860
Drugphantolid

AR PGR

1.75e-0441242ctd:C033117
Drugdiethyltin

CACNA1A PGR

1.75e-0441242CID000115013
DrugSC 38249

TBXAS1 RYR3

1.75e-0441242CID000134834
Drugciclesonide

AR PGR

1.75e-0441242ctd:C120481
Drugfenvalerate

AR PGR SCN2A SCN3A SCN10A

1.91e-04971245ctd:C017690
Drugprocaine

CACNA1A CACNA1E RYR3 SCN3A SCN9A SCN10A

1.94e-041531246CID000004914
DrugTeniposide

ABCC1 AR PGR

1.95e-04211243ctd:D013713
Drugpropafenone

MR1 SCN3A SCN5A SCN9A SCN10A

2.00e-04981245CID000004932
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.18e-15101237DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.18e-15101237DOID:0080422 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

CACNA1A CACNA1E SLC13A3 SLC1A1 SLC1A3 SLC1A6 SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A DYNC1H1

8.02e-1516312314DOID:1826 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.43e-14121237DOID:0060170 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

HCN1 SCN1A SCN2A SCN3A SCN9A HDAC2

3.28e-10221236DOID:2030 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

HCN1 SCN1A SCN2A SCN9A

3.56e-0891234C3502809
DiseaseEpilepsy

HCN1 SLC1A1 SLC1A3 SCN1A SCN2A SCN8A SCN9A

3.86e-071091237C0014544
DiseaseEpilepsy, Cryptogenic

HCN1 SLC1A1 SLC1A3 SCN1A SCN2A SCN8A

1.25e-06821236C0086237
DiseaseAwakening Epilepsy

HCN1 SLC1A1 SLC1A3 SCN1A SCN2A SCN8A

1.25e-06821236C0751111
DiseaseAura

HCN1 SLC1A1 SLC1A3 SCN1A SCN2A SCN8A

1.25e-06821236C0236018
Diseaseepisodic ataxia type 6 (implicated_via_orthology)

SLC1A1 SLC1A3 SLC1A6

1.40e-0661233DOID:0050994 (implicated_via_orthology)
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

1.72e-0521232C4551549
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A SCN9A

1.96e-05131233C0751122
DiseaseDystonia

CACNA1A CACNA1E COL6A3 MR1 PNPT1

3.08e-05861235C0013421
DiseaseP wave duration

HCN1 SCN5A SCN10A

3.10e-05151233EFO_0005094
Diseaseneurodegenerative disease (implicated_via_orthology)

PTCH1 SLC1A1 SLC1A3 SLC1A6 PTCH2 DYNC1H1

3.36e-051451236DOID:1289 (implicated_via_orthology)
DiseaseTremor, Rubral

CACNA1A HCN1 SCN8A

3.80e-05161233C0750940
DiseaseAtaxia, Appendicular

CACNA1A HCN1 SCN8A

3.80e-05161233C0750937
DiseaseAtaxia, Motor

CACNA1A HCN1 SCN8A

3.80e-05161233C0278161
DiseaseAtaxia, Sensory

CACNA1A HCN1 SCN8A

3.80e-05161233C0240991
DiseaseAbnormal coordination

CACNA1A HCN1 SCN8A

3.80e-05161233C0520966
DiseaseAtaxia, Truncal

CACNA1A HCN1 SCN8A

3.80e-05161233C0427190
DiseaseB Virus Infection

SCN8A SCN9A

5.16e-0531232C0037140
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

5.16e-0531232cv:C5575231
DiseasePostherpetic neuralgia

SCN8A SCN9A

5.16e-0531232C0032768
DiseaseHerpesviridae Infections

SCN8A SCN9A

5.16e-0531232C0019372
DiseasePrimary Erythermalgia

SCN9A SCN10A

5.16e-0531232C0014805
Diseasesick sinus syndrome (implicated_via_orthology)

HCN1 SCN5A

5.16e-0531232DOID:13884 (implicated_via_orthology)
DiseaseFamilial or sporadic hemiplegic migraine

CACNA1A SCN1A

5.16e-0531232cv:CN295307
DiseaseFamilial hemiplegic migraine

CACNA1A SCN1A

5.16e-0531232cv:C0338484
DiseasePAROXYSMAL EXTREME PAIN DISORDER

SCN9A SCN10A

5.16e-0531232C1833661
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1E

5.16e-0531232DOID:0111181 (implicated_via_orthology)
DiseaseAlternating hemiplegia of childhood

CACNA1A SLC1A3

1.03e-0441232C0338488
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1E

1.03e-0441232DOID:6364 (implicated_via_orthology)
DiseaseBrugada ECG Pattern

SCN5A SCN10A

1.03e-0441232C1721096
DiseaseBASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1

PTCH1 PTCH2

1.03e-0441232605462
DiseaseBasal cell carcinoma, susceptibility to, 1

PTCH1 PTCH2

1.03e-0441232cv:C2751544
DiseaseOculo-dento-digital syndrome

PTCH1 PTCH2

1.03e-0441232C0812437
DiseaseEpisodic Ataxia

UBR4 SLC1A3

1.03e-0441232C1720189
DiseaseHereditary episodic ataxia

CACNA1A SLC1A3

1.03e-0441232cv:C1720189
DiseaseAtaxia

CACNA1A HCN1 SCN8A

1.52e-04251233C0004134
Diseaselow tension glaucoma (implicated_via_orthology)

SLC1A1 SLC1A3

1.71e-0451232DOID:13544 (implicated_via_orthology)
DiseaseBasal Cell Nevus Syndrome

PTCH1 PTCH2

1.71e-0451232C0004779
DiseaseEPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1

HCN1 SCN1A

2.56e-0461232C3463992
Diseasecongenital muscular dystrophy (implicated_via_orthology)

COL6A3 DYNC1H1

2.56e-0461232DOID:0050557 (implicated_via_orthology)
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

2.56e-0461232C0220669
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

3.57e-0471232C0149886
Diseaseprotocadherin alpha-7 measurement

CPNE2 CPNE1

3.57e-0471232EFO_0801973
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

3.57e-0471232C0751057
Diseaseelectrocardiography, PR interval

SCN5A SCN10A

3.57e-0471232EFO_0004327, EFO_0004462
DiseaseCongenital Pain Insensitivity

SCN9A SCN10A

3.57e-0471232C0002768
DiseaseHereditary Sensory Autonomic Neuropathy, Type 5

SCN9A SCN10A

3.57e-0471232C0020075
DiseaseX-24328 measurement

HCN1 CPNE5

3.57e-0471232EFO_0800873
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1E

3.57e-0471232DOID:0050951 (implicated_via_orthology)
Diseasediabetic nephropathy

TBXAS1 RYR3 PGR PCSK6 STEAP1B

4.24e-041501235EFO_0000401
Diseaseresponse to anticonvulsant

ABCC1 COL6A3 SYDE2 LRRTM4

4.49e-04851234GO_0036277
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

4.75e-0481232C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

4.75e-0481232C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

4.75e-0481232C0338479
DiseaseX-linked infantile spasms

HCN1 SCN1A

4.75e-0481232C4552072
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

4.75e-0481232C0751120
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

4.75e-0481232C0438414
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

4.75e-0481232C0393703
DiseaseIntellectual Disability

RALGAPA1 CACNA1E PNPT1 ERLIN2 SCN1A SCN3A SCN8A DYNC1H1

5.88e-044471238C3714756
DiseaseFebrile Convulsions

SCN1A SCN2A

6.09e-0491232C0009952
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

6.09e-0491232C0014550
Diseasesupraventricular ectopy

SCN5A SCN10A

6.09e-0491232EFO_0009277
Diseaseprotein FAM163B measurement

CPNE2 CPNE1

6.09e-0491232EFO_0802936
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

7.59e-04101232C0917800
DiseaseBipolar Disorder

CACNA1A GRIK4 RFX4 SLC1A1 SLC1A3 SLC1A6 SCN2A SCN8A

8.96e-044771238C0005586
Diseasecell growth regulator with EF hand domain protein 1 measurement

CPNE2 CPNE1

9.25e-04111232EFO_0801461
Disease3-hydroxyanthranilate 3,4-dioxygenase measurement

CPNE2 CPNE1

9.25e-04111232EFO_0021862
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

9.25e-04111232C0393702
Diseasetyrosine measurement

GLS2 SLCO1B1 ADCYAP1R1 AP1G1

9.59e-041041234EFO_0005058
DiseaseGastrointestinal Stromal Sarcoma

SALL3 PTCH1 PTCH2

1.00e-03471233C3179349
Diseasebasal cell carcinoma (is_implicated_in)

PTCH1 PTCH2

1.11e-03121232DOID:2513 (is_implicated_in)
Diseasedecanoylcarnitine measurement

ABCC1 DHX34

1.11e-03121232EFO_0021039
DiseaseGastrointestinal Stromal Tumors

SALL3 PTCH1 PTCH2

1.20e-03501233C0238198
DiseaseBrugada Syndrome 1

SCN5A SCN10A

1.30e-03131232C4551804
DiseaseMalformations of Cortical Development

SLC1A1 DYNC1H1

1.52e-03141232C1955869
DiseaseCortical Dysplasia

SLC1A1 DYNC1H1

1.52e-03141232C0431380
DiseaseT wave morphology measurement

SCN5A SCN10A

1.52e-03141232EFO_0008398
DiseaseMMR-related febrile seizures

SCN1A SCN2A

1.75e-03151232EFO_0006519
Diseaseheart rate response to recovery post exercise

CPNE8 CPNE5 SCN10A

1.76e-03571233EFO_0009185
DiseaseNeuralgia, Supraorbital

SCN9A SCN10A

1.99e-03161232C0038870
DiseaseNeuralgia

SCN9A SCN10A

1.99e-03161232C0027796
DiseaseRomano-Ward Syndrome

SCN5A SCN10A

1.99e-03161232C0035828
DiseaseNeuralgia, Atypical

SCN9A SCN10A

1.99e-03161232C0234247
DiseaseNeuralgia, Stump

SCN9A SCN10A

1.99e-03161232C0234249
Diseaseendometriosis (biomarker_via_orthology)

PGR HDAC2

1.99e-03161232DOID:289 (biomarker_via_orthology)
DiseaseNeuralgia, Iliohypogastric Nerve

SCN9A SCN10A

1.99e-03161232C0423712
DiseaseNeuralgia, Perineal

SCN9A SCN10A

1.99e-03161232C0423711
DiseaseParoxysmal Nerve Pain

SCN9A SCN10A

1.99e-03161232C0751373
DiseaseNerve Pain

SCN9A SCN10A

1.99e-03161232C0751372
DiseaseNeuralgia, Ilioinguinal

SCN9A SCN10A

1.99e-03161232C0751371
DiseaseNeuralgia, Vidian

SCN9A SCN10A

1.99e-03161232C0042656
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

1.99e-03161232C0393706
DiseaseInborn Errors of Metabolism

MYO5B SERPINA7

2.25e-03171232C0025521
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

2.52e-03181232HP_0002373
Diseaseheart rate

CPNE8 CPNE5 RFX4 TMEM244 SCN5A

2.57e-032251235EFO_0004326

Protein segments in the cluster

PeptideGeneStartEntry
VGPAAVIVLVNMLIG

ADGRB2

1081

O60241
VSGIPSLQVVLKSIM

CACNA1A

206

O00555
AVVQASKLPMSIIIV

CPNE2

456

Q96FN4
VSGIPSLQIVLKSIM

CACNA1E

201

Q15878
AVKATMILVPLLGIQ

CALCR

341

P30988
MELVQHIGIPASKII

AZIN2

96

Q96A70
PMKSVLVVALLVIFQ

CCR7

6

P32248
VLQFVPMEVLLKGAL

CMTR2

721

Q8IYT2
VMAKVVVLSPGTLQE

AP5Z1

156

O43299
KMTYVGLQLIVVILP

AGO4

501

Q9HCK5
IQEIVTGNPTVIKMV

IQGAP1

1041

P46940
KAISGVLMPTVLQAL

RFX4

261

Q33E94
VVGNLGMIIIIKINP

OR5D14

41

Q8NGL3
VVGNLGMIVIIKINP

OR5D16

41

Q8NGK9
VPQLVRILKNLIMSG

AP1G1

216

O43747
PIMQGIAILAVVTNA

ANO6

726

Q4KMQ2
EVVIMEVQGLKSLAP

CADPS

401

Q9ULU8
LLLVPVNKVIATRIM

ABCC10

431

Q5T3U5
ILIGLTQNPIMEKVT

OR4C12

11

Q96R67
NQIMPKTGFLIIVLV

MAGEA1

186

P43355
MPKTGLLIIVLAIIA

MAGEA2

196

P43356
MPKAGLLIIVLAIIA

MAGEA3

196

P43357
PKTGLLIIVLGVIFM

MAGEB16

201

A2A368
ITQLKGMSVVLVLLP

LRRTM4

6

Q86VH4
AVQEIMIPASKAGLV

FUBP1

186

Q96AE4
MKVLAAGVVPLLLVL

LIF

1

P15018
MIIAIGGVIVASVLV

LRFN1

536

Q9P244
LPVALLETMFGVKVI

LCLAT1

91

Q6UWP7
VSAPMVAGIIALALE

PCSK6

421

P29122
MPVKVEAAIALQVLI

IPO7

511

O95373
LATPIMNGKDVVAVI

PDE6B

176

P35913
ATPIVVGKEVLAVIM

PDE6C

181

P51160
MPKLLQGVITVIDVF

HRNR

1

Q86YZ3
QRNVAIMKSIIPAIV

LDHC

111

P07864
LSAITQPMVVVAIVG

GBP1

31

P32455
AVSGAILLVVPNVMG

GLS2

416

Q9UI32
MEKPTLAVIGLVQSL

FMO6P

361

O60774
MAEIISVQVPKILSG

AR

896

P10275
IVVIVGISNMDPSKI

PRSS54

91

Q6PEW0
IAILMILAQKTPGGL

DEFB116

11

Q30KQ4
KVPEIMGVICAQLSI

MROH8

381

Q9H579
GIIVILVQKLQSPDM

ADCYAP1R1

326

P41586
LTSMAPGLVIQAVRV

ERLIN2

156

O94905
MNPNVVVISVLAILS

PTPRO

816

Q16827
NLVIVPKMLGTLLAQ

OR10A2

61

Q9H208
LVIVPKMLGTLIIQD

OR10A4

76

Q9H209
KVLEGQPVNMLVTTV

DCHS2

1306

Q6V1P9
EVIAAQLPKILAGMV

PGR

911

P06401
ECMVPVVLGAKQLIL

UPF1

656

Q92900
IMMVGNLVIIPVGIT

HCN1

151

O60741
VTVNGVDMKLPVVLA

FCGBP

3731

Q9Y6R7
AGIPQAGLVTMVIVL

SLC1A3

441

P43003
IVGMSATLPNLELVA

POLQ

261

O75417
LKIVVLMLTGEVPEQ

COL6A3

2736

P12111
LINMGVIPTLVKLLG

RAP1GDS1

176

P52306
AGIPQAGLVTMVIVL

SLC1A6

466

P48664
ILIQSVCETMVPKLV

DYNC1H1

2136

Q14204
ETMCQILPKGVVAVL

GRIK4

81

Q16099
VEVVKTFNLPLLMLG

HDAC2

286

Q92769
LEKGLIVPMENVATI

BTBD9

416

Q96Q07
AQLPVDVVIGKMLIL

DHX34

581

Q14147
RIALKILMLVGVQPA

SLC13A3

111

Q8WWT9
QVLVKILPVMVTLVP

SLC15A3

311

Q8IY34
LVVPKGNTAVSVLML

SCAMP3

266

O14828
GVAAAAVPLILEQLM

SALL3

196

Q9BXA9
IVNASKLPMSIIIVG

CPNE8

456

Q86YQ8
VPQAGLVTMVIVLSA

SLC1A1

411

P43005
VNAAKLPMSIIIVGV

CPNE5

476

Q9HCH3
VRASNLPMSVIIVGV

CPNE1

436

Q99829
PIKLLIGVIAAVNML

LGR5

591

O75473
LVIVPKMLGTLLAQD

OR10A5

76

Q9H207
VMKAVSGSIVLVIVL

MR1

301

Q95460
MILTNKVIAILGIVI

OR52E5

136

Q8NH55
NLGPSVLAGVAVMVL

ABCC1

461

P33527
QGLVKVMTLCPIETL

GLMN

366

Q92990
VVEKENIGLMVPLLI

SYDE2

821

Q5VT97
LPLVTMLIGVLVLKN

SLC35D3

111

Q5M8T2
LAIAMVALIPGTLIK

TMEM41A

226

Q96HV5
IAAVSVGIGVPIMLA

RNF19B

416

Q6ZMZ0
NLAMAVIISKGVPQL

SPAG6

326

O75602
ITQVVVSRILMAAPG

SFXN1

226

Q9H9B4
LQVLMAEGLLPAVKV

SMG5

646

Q9UPR3
LVKPVMAVTTIILQA

TMEM184A

191

Q6ZMB5
IMGFLGIKLSAIPVV

PTCH2

1006

Q9Y6C5
PIKNVEMLASVLVAI

HEPH

1101

Q9BQS7
VPSQPVVELVLMKVL

NEPRO

126

Q6NW34
MGLIGIKLSAVPVVI

PTCH1

1071

Q13635
MNITLGVPRIKEIIN

POLR3A

1061

O14802
RVVVNALVGAIPSIM

SCN5A

1321

Q14524
VNALIGAIPSIMNVL

SCN9A

1311

Q15858
QNIPVGIMMIIIAAL

SCAMP1

256

O15126
LPKESSGIMALQILV

SLC41A2

151

Q96JW4
VVVPKMLVVILTGDH

OR6T1

76

Q8NGN1
IVLVAKLGPQVMAAA

WIZ

636

O95785
MRVVVNALVGAIPSI

SCN3A

1321

Q9NY46
LVVAGAPKSQIVMLE

PNPT1

216

Q8TCS8
IPIKIVMEAIQQASV

PNPT1

566

Q8TCS8
ILNAIAMIGPIIGFT

SLCO1B1

211

Q9Y6L6
IMAELGIPITSVIKI

SPAG17

236

Q6Q759
VVNALLGAIPSIMNV

SCN1A

1336

P35498
VVKTVVVMLQNVVPA

SESTD1

76

Q86VW0
ILVINKVLPMVSITL

STEAP1

111

Q9UHE8
NKVLPMVSITLLALV

STEAP1B

96

Q6NZ63
MAKALLTFGPLVVIV

CTSO

231

P43234
IISGLIVVVLKVVGM

CLEC5A

6

Q9NY25
VTGQIVHALPVLMAV

CLCNKB

491

P51801
MALQVRVAPSKVVLQ

TMEM244

1

Q5VVB8
KLITAVGITVVMVLN

SLC7A11

166

Q9UPY5
AILIIIVPGVMQLIK

SLC7A11

201

Q9UPY5
ILELVQKGIPVTMTI

RNF149

171

Q8NC42
VNGPMVTVALSVALL

TBXAS1

11

P24557
AIVNGKVLPIMVRAT

RALGAPA1

1961

Q6GYQ0
AVVPLMGLLESIAVA

SLC26A11

311

Q86WA9
GCVALPVLMNIKAVI

RMND5B

291

Q96G75
LIPQGKLVLMIGDIV

TAS2R9

256

Q9NYW1
KLVLMIGDIVTVIFP

TAS2R9

261

Q9NYW1
QFVPVLKLIGTLLVM

RYR3

1721

Q15413
VDALVGAIPSIMNVL

SCN10A

1271

Q9Y5Y9
VGLIQDLKPNTIMVL

SERPINA7

186

P05543
VVNALLGAIPSIMNV

SCN2A

1326

Q99250
VVNALVGAIPSIMNV

SCN8A

1316

Q9UQD0
AVLGKVSPIQLLIMT

RHCG

141

Q9UBD6
TGLKAAMQIQRVVIP

ZNF333

141

Q96JL9
LTVELMGTVAKQLVP

VEGFB

56

P49765
VVILGPVADIAMQKL

TJP3

621

O95049
VPLVVMVKPDTFLIQ

UBR4

2186

Q5T4S7
VNIKTPVVVENITLM

UBR4

4001

Q5T4S7
ILSAVVQVNGTPVML

TYSND1

456

Q2T9J0
LEIIKNVMIPATIAQ

LRRC8C

451

Q8TDW0
IKIAEGVLQPMIVSA

MYO5B

1606

Q9ULV0