Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncell adhesion molecule binding

FGA KIF5B DMD ABCF3 NRXN2 SPTAN1 EIF4G2

8.26e-05599367GO:0050839
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

TCHH KRT24 NDEL1 KRT19

2.61e-0599364GO:0045104
GeneOntologyBiologicalProcessintermediate filament-based process

TCHH KRT24 NDEL1 KRT19

2.72e-05100364GO:0045103
GeneOntologyCellularComponentdystrophin-associated glycoprotein complex

DMD KRT19

5.37e-0420362GO:0016010
GeneOntologyCellularComponentcostamere

DMD KRT19

6.52e-0422362GO:0043034
GeneOntologyCellularComponentaxon

TAOK2 TSC1 KIF5B DMD NDEL1 SPTAN1 EIF4G2

7.05e-04891367GO:0030424
GeneOntologyCellularComponentgrowth cone

TAOK2 TSC1 KIF5B NDEL1

8.08e-04245364GO:0030426
GeneOntologyCellularComponentnuclear speck

SRRM1 PSME4 CWC22 NSRP1 CHD5

8.10e-04431365GO:0016607
GeneOntologyCellularComponentglycoprotein complex

DMD KRT19

8.44e-0425362GO:0090665
GeneOntologyCellularComponentsite of polarized growth

TAOK2 TSC1 KIF5B NDEL1

9.10e-04253364GO:0030427
GeneOntologyCellularComponentintermediate filament cytoskeleton

KRT24 DMD NDEL1 KRT19

1.05e-03263364GO:0045111
DomainSTAG

STAG3L4 STAG3

2.29e-054372PF08514
DomainSTAG

STAG3L4 STAG3

2.29e-054372IPR013721
DomainARM-type_fold

RANBP6 PSME4 CWC22 DOCK8 STAG3 EIF4G2

4.95e-05339376IPR016024
DomainMI

CWC22 EIF4G2

5.70e-056372PS51366
DomainMA3

CWC22 EIF4G2

5.70e-056372SM00544
DomainMA3

CWC22 EIF4G2

5.70e-056372PF02847
DomainInitiation_fac_eIF4g_MI

CWC22 EIF4G2

5.70e-056372IPR003891
DomainMIF4G

CWC22 EIF4G2

1.70e-0410372SM00543
DomainMIF4G

CWC22 EIF4G2

1.70e-0410372PF02854
DomainMIF4G-like_typ-3

CWC22 EIF4G2

1.70e-0410372IPR003890
DomainPrefoldin

KRT24 TANK KRT19

3.88e-0472373IPR009053
DomainMIF4-like

CWC22 EIF4G2

3.95e-0415372IPR016021
Domain-

CWC22 EIF4G2

3.95e-04153721.25.40.180
DomainSpectrin

DMD SPTAN1

9.41e-0423372PF00435
DomainSpectrin_repeat

DMD SPTAN1

1.50e-0329372IPR002017
DomainSpectrin/alpha-actinin

DMD SPTAN1

1.82e-0332372IPR018159
DomainSPEC

DMD SPTAN1

1.82e-0332372SM00150
DomainARM-like

RANBP6 PSME4 DOCK8 STAG3

1.94e-03270374IPR011989
DomainKeratin_I

KRT24 KRT19

3.43e-0344372IPR002957
DomainWW

DMD PLEKHA7

3.90e-0347372PF00397
DomainWW

DMD PLEKHA7

4.07e-0348372SM00456
DomainWW_DOMAIN_2

DMD PLEKHA7

4.58e-0351372PS50020
DomainWW_DOMAIN_1

DMD PLEKHA7

4.58e-0351372PS01159
DomainWW_dom

DMD PLEKHA7

4.76e-0352372IPR001202
DomainIntermediate_filament_CS

KRT24 KRT19

6.91e-0363372IPR018039
DomainHEAT_REPEAT

RANBP6 PSME4

8.47e-0370372PS50077
DomainFilament

KRT24 KRT19

8.71e-0371372SM01391
DomainIF

KRT24 KRT19

8.95e-0372372PS00226
DomainFilament

KRT24 KRT19

9.19e-0373372PF00038
Domain-

RANBP6 PSME4 STAG3

9.56e-032223731.25.10.10
DomainIF

KRT24 KRT19

9.93e-0376372IPR001664
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

FGA TSC1 ATP6V1G2 KIF5B DMD NDEL1 NRXN2 PLEKHA7 KRT19 DOCK8 SPTAN1 EIF4G2

1.60e-081431371237142655
Pubmed

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

DMD KRT19

3.30e-06337216000376
Pubmed

Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex.

KRT19 SPTAN1

3.30e-06337215247274
Pubmed

Structural and functional evaluation of branched myofibers lacking intermediate filaments.

DMD KRT19

3.30e-06337222592402
Pubmed

Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway.

FGA DMD

6.60e-06437218593877
Pubmed

Beta-dystrobrevin interacts directly with kinesin heavy chain in brain.

KIF5B DMD

6.60e-06437214600269
Pubmed

STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion.

STAG3L4 STAG3

1.10e-05537210698974
Pubmed

Identification of 14-3-3epsilon substrates from embryonic murine brain.

TSC1 KIF5B NDEL1 DOCK8

1.19e-0513237416944949
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SLTM MRPS27 SRRM1 NRXN2 CWC22 NSRP1 SPTAN1 SCAF4

1.48e-05108237838697112
Pubmed

Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.

SLTM KIF5B KRT19 SPTAN1 EIF4G2

1.48e-0529537526209609
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

KIF5B DMD NDEL1 SPTAN1

2.02e-0515137417043677
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

MRPS27 SRRM1 CWC22 SPTAN1

2.29e-0515637422952844
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

TSC1 KIF5B TANK CEP120 PLEKHA7 KRT19 EIF4G2

2.82e-0585337728718761
Pubmed

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.

SRRM1 CWC22 KRT19 SPTAN1

3.14e-0516937423084401
Pubmed

Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages.

TAOK2 RIOK2

3.95e-05937231471107
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

SLTM SRRM1 KIF5B RIOK2 NSRP1 SPTAN1 CHD5

5.55e-0594937736574265
Pubmed

Gene expression analysis of myeloid and lymphoid lineage markers during mouse haematopoiesis.

CSF1R CEBPG

6.02e-051137216925795
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SLTM TSC1 KIF5B ABCF3 PSME4 RIOK2 SPTAN1 EIF4G2

7.24e-05135337829467282
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

MRPS27 SRRM1 TSC1 KIF5B ABCF3 RIOK2 SPTAN1 EIF4G2

9.90e-05141537828515276
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SRRM1 TSC1 ATP6V1G2 KIF5B DMD KRT19 SPTAN1 CHD5

1.13e-04144237835575683
Pubmed

Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.

TCHH KRT19

1.15e-041537223178882
Pubmed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

FGA SRRM1 DMD ABCF3 KRT19 DOCK8

1.22e-0474237626871637
Pubmed

In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.

RANBP6 TSC1 EIF4G2

1.35e-049337325211037
Pubmed

A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18.

KIF5B CSF1R

1.48e-04173721354644
Pubmed

A human MAP kinase interactome.

KIF5B DMD NDEL1 KRT19 SPTAN1

1.57e-0448637520936779
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

SRRM1 CWC22 CHD5

1.82e-0410337332744500
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TAOK2 PSME4 NRXN2 CWC22 CHD5

2.33e-0452937514621295
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

RANBP6 KIF5B TANK NDEL1

2.36e-0428537432838362
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

SLTM KRT24 DMD SPTAN1 EIF4G2

2.52e-0453837528524877
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

DMD NDEL1 SPTAN1

2.86e-0412037331413325
Pubmed

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

SRRM1 TSC1 DCAF8 CWC22

2.86e-0430037428561026
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

KIF5B ABCF3 PLEKHA7 SPTAN1 EIF4G2

3.15e-0456537525468996
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

TAOK2 ATP6V1G2 KIF5B NDEL1 DCAF8 KRT19 SPTAN1

3.74e-04129337715342556
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

SRRM1 DMD PLEKHA7 DOCK8 NSRP1 EIF4G2

3.80e-0491637632203420
Pubmed

Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium.

DMD KRT19

3.80e-042737227173853
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

SRRM1 TANK KRT19 BBC3 SPTAN1 SCAF4

3.93e-0492237627609421
Pubmed

Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.

DMD KRT19

4.09e-042837225179606
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

FGA SRRM1 KIF5B SPTAN1 EIF4G2

4.38e-0460737539147351
Pubmed

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.

PSME4 CHD5

4.39e-042937227649575
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SLTM SRRM1 CWC22 NSRP1 SCAF4 EIF4G2

4.71e-0495437636373674
Pubmed

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

KIF5B NDEL1 SPTAN1

5.17e-0414737316959763
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

TAOK2 MRPS27 SRRM1 KIF5B RIOK2 SPTAN1 SCAF4

5.31e-04137137736244648
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

KIF5B NSRP1 SPTAN1 SCAF4

5.69e-0436037433111431
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

SLTM MRPS27 KIF5B PLEKHA7 CWC22 SPTAN1 EIF4G2

6.68e-04142537730948266
Pubmed

An investigation into the human serum "interactome".

FGA DMD BBC3

6.86e-0416237315174051
Pubmed

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

FGA KIF5B DMD DOCK8

7.11e-0438237437249651
Pubmed

Identification and applications of repetitive probes for gene mapping in the mouse.

CSF1R SPTAN1

7.56e-04383721673105
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

MRPS27 FGA KIF5B SPTAN1

7.68e-0439037417643375
Pubmed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

TAOK2 TSC1 NDEL1 DOCK8

8.59e-0440237424722188
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

MRPS27 KIF5B PARP14 KRT19 SPTAN1

8.93e-0471137533022573
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

SLTM MRPS27 SRRM1 SPTAN1 SCAF4

9.04e-0471337529802200
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

SLTM ABCF3 CEBPG PSME4 PLEKHA7 EIF4G2

9.19e-04108437611544199
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

SLTM TSC1 CEP120 NDEL1

9.33e-0441137435182466
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

DCAF8 PSME4 RIOK2

9.76e-0418337331932471
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

SRRM1 CSF1R PLEKHA7 EIF4G2

1.01e-0342037428065597
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

DMD PARP14 SPTAN1

1.04e-0318737326460568
InteractionKCTD13 interactions

FGA TSC1 ATP6V1G2 KIF5B DMD NDEL1 NRXN2 PLEKHA7 KRT19 DOCK8 SPTAN1 EIF4G2

4.17e-0613943712int:KCTD13
InteractionKIF5A interactions

TSC1 KIF5B NDEL1 CEBPG

3.07e-0598374int:KIF5A
InteractionCPSF6 interactions

TAOK2 SLTM SRRM1 KIF5B CWC22 NSRP1 SCAF4

4.14e-05526377int:CPSF6
InteractionPIP4K2A interactions

TAOK2 SLTM RIOK2 CWC22 NSRP1

4.45e-05216375int:PIP4K2A
InteractionSOS1 interactions

SRRM1 DMD CSF1R SPTAN1

6.15e-05117374int:SOS1
InteractionKLC4 interactions

TSC1 KIF5B NDEL1 KRT19

7.95e-05125374int:KLC4
InteractionRIOK2 interactions

MRPS27 ABCF3 RIOK2 NSRP1

8.20e-05126374int:RIOK2
InteractionGAGE5 interactions

SLTM NSRP1 SCAF4

1.18e-0452373int:GAGE5
InteractionCFAP141 interactions

SLTM NSRP1 SCAF4

1.40e-0455373int:CFAP141
InteractionTBC1D31 interactions

TANK CEP120 KRT19

1.48e-0456373int:TBC1D31
InteractionKRT79 interactions

KRT24 TANK KRT19

1.73e-0459373int:KRT79
InteractionCDK9 interactions

SLTM MRPS27 KIF5B KRT19 NSRP1 SPTAN1 EIF4G2

2.15e-04685377int:CDK9
InteractionCCDC77 interactions

TANK CEP120 KRT19

2.20e-0464373int:CCDC77
InteractionKRT80 interactions

KRT24 TANK KRT19

2.20e-0464373int:KRT80
InteractionSNRPA interactions

SLTM SRRM1 RIOK2 CWC22 NSRP1 SCAF4

2.25e-04482376int:SNRPA
Cytoband17q21.2

KRT24 KRT19

1.47e-037037217q21.2
GeneFamilyKeratins, type I

KRT24 KRT19

5.73e-0428232608
CoexpressionMARTINEZ_TP53_TARGETS_DN

SRRM1 TCHH DMD CSF1R NDEL1 CEBPG RIOK2

2.11e-05615377M8673
CoexpressionMARTINEZ_TP53_TARGETS_DN

SRRM1 TCHH DMD CSF1R NDEL1 CEBPG RIOK2

3.28e-05659377MM1040
ToppCelldroplet-Tongue-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLTM SRRM1 KIF5B NDEL1

1.75e-05188374d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

RHCG CCDC81 KRT24 KRT19

2.14e-05198374e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

RHCG CCDC81 KRT24 KRT19

2.14e-05198374e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

TAOK2 MRPS27 KIF5B SPTAN1

2.23e-052003741fa8422fd820d21e285a7e7c4c6fbd8b7277d2af
DiseaseWest Syndrome

TSC1 SPTAN1

4.15e-0424372C0037769
Diseaseupper respiratory tract disorder

RANBP6 KRT19

5.67e-0428372MONDO_0004867
Diseaseintellectual disability (is_implicated_in)

TSC1 DMD

6.51e-0430372DOID:1059 (is_implicated_in)
Diseaseautism spectrum disorder (implicated_via_orthology)

TAOK2 TSC1 NRXN2

9.16e-04152373DOID:0060041 (implicated_via_orthology)
DiseaseNeuroblastoma

DOCK8 CHD5

1.60e-0347372C0027819
Diseasewaist circumference

TAOK2 CEP120 DMD CWC22

1.99e-03429374EFO_0004342
DiseaseMouth Neoplasms

FGA TSC1

2.10e-0354372C0026640
DiseaseMalignant neoplasm of mouth

FGA TSC1

2.10e-0354372C0153381
Diseaseneurofilament light chain measurement

STAG3L4 EIF4G2

2.34e-0357372EFO_0009178

Protein segments in the cluster

PeptideGeneStartEntry
QYRREREHEFQSKQQ

ATP6V1G2

46

O95670
DDLNAQYERRRQEEQ

BBC3

146

Q9BXH1
RKQVNYNDASQEDQE

CHD5

1346

Q8TDI0
KQERLLNQQREYEAQ

ABCF3

416

Q9NUQ8
ENRNLQAEYDRLKQQ

DMD

3516

P11532
KYSQREQERDRQQND

NSRP1

386

Q9H0G5
ENASRDRKRYQQEVD

KIF5B

886

P33176
DVRADSERQNQEYQR

KRT19

351

P08727
NQQTNDRKQKERRQE

CWC22

736

Q9HCG8
VRIYDQRKIDENENN

DCAF8

356

Q5TAQ9
RNRDEGSYQVDQSRN

NRXN2

1661

Q9P2S2
EQNRREAEERFNKQS

KRT24

326

Q2M2I5
ENRTRNVDVYDKREN

EIF4G2

176

P78344
ERECSQQAQQRKNDY

PARP14

1271

Q460N5
QEQAQEDRRERDYTN

CSF1R

911

P07333
DFEKQNEEARRTNRQ

DOCK8

221

Q8NF50
MDNRQENEIKQRQYR

CCDC81

436

Q6ZN84
ELNRLRQQEQKQYQD

CEP120

906

Q8N960
NNRDNTYNRVSEDLR

FGA

121

P02671
NDRERYGNRNDDRDN

SCAF4

1011

O95104
YGNRNDDRDNSNRDR

SCAF4

1016

O95104
NSDEYRQRRERNNMA

CEBPG

61

P53567
QREQQQREQAKQEYQ

MRPS27

391

Q92552
ERQEQEGEQYRSQRD

PLEKHA7

336

Q6IQ23
RQQQQLRYEQEKRNS

SLTM

711

Q9NWH9
QQKTENYEQRIREQQ

TANK

31

Q92844
NQLEYNKRREQELRQ

TAOK2

716

Q9UL54
QELRQVKRQEENYDQ

RANBP6

816

O60518
KEQARYNQLQEQRDT

TSC1

756

Q92574
HQDNNQRQYEAERNK

STAG3

256

Q9UJ98
QRRQDLEDSLQAQQY

SPTAN1

881

Q13813
ADSVQQRRQYRRQNQ

SRRM1

476

Q8IYB3
QRRQYRRQNQQSSSD

SRRM1

481

Q8IYB3
EDINQRQYEAERNKG

STAG3L4

116

Q8TBR4
RQQEKNADALRNYEN

PSME4

1131

Q14997
NRTENYNRQDGQRVQ

RIOK2

421

Q9BVS4
RRNLEQSKERQNSVY

RHCG

201

Q9UBD6
QERQYREEEQLQQEE

TCHH

926

Q07283
EEQEQRLRQERDRQY

TCHH

1831

Q07283
RNRDLQADNQRLKYE

NDEL1

61

Q9GZM8