Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainARM-type_fold

IPO5 THADA NBEAL1 XPO6 ARFGEF2 ARFGEF1 CUL9 PRKDC TANGO6 XPO7

6.56e-063399210IPR016024
DomainARM-like

IPO5 ARID1B XPO6 ARFGEF2 ARFGEF1 CUL9 PRKDC TANGO6 XPO7

7.36e-06270929IPR011989
Domain-

IPO5 ARID1B XPO6 ARFGEF2 ARFGEF1 CUL9 PRKDC TANGO6

1.39e-052229281.25.10.10
DomainTSP_1

CCN6 CCN5 ADAMTS19 ADAMTS6 THSD7B

1.46e-0563925PF00090
DomainTSP1

CCN6 CCN5 ADAMTS19 ADAMTS6 THSD7B

1.70e-0565925SM00209
DomainTSP1_rpt

CCN6 CCN5 ADAMTS19 ADAMTS6 THSD7B

1.70e-0565925IPR000884
DomainTSP1

CCN6 CCN5 ADAMTS19 ADAMTS6 THSD7B

1.70e-0565925PS50092
Domain-

TLN1 TLN2

2.40e-0529221.20.1420.10
DomainVBS

TLN1 TLN2

2.40e-052922PF08913
DomainVinculin-bd_dom

TLN1 TLN2

2.40e-052922IPR015009
DomainTalin_cent

TLN1 TLN2

2.40e-052922IPR015224
DomainTalin_middle

TLN1 TLN2

2.40e-052922PF09141
DomainIMPORTIN_B_NT

IPO5 XPO6 XPO7

4.05e-0514923PS50166
DomainTalin-1

TLN1 TLN2

7.18e-053922IPR015710
DomainImportin-beta_N

IPO5 XPO6 XPO7

7.48e-0517923IPR001494
DomainILWEQ_dom

TLN1 TLN2

1.43e-044922IPR002558
DomainILWEQ

TLN1 TLN2

1.43e-044922SM00307
DomainDCB_dom

ARFGEF2 ARFGEF1

1.43e-044922IPR032629
DomainFERM_f0

TLN1 TLN2

1.43e-044922PF16511
DomainILWEQ

TLN1 TLN2

1.43e-044922PD011820
Domain-

TLN1 TLN2

1.43e-0449221.20.1410.10
DomainSec7_C

ARFGEF2 ARFGEF1

1.43e-044922IPR015403
DomainDUF1981

ARFGEF2 ARFGEF1

1.43e-044922PF09324
DomainI_LWEQ

TLN1 TLN2

1.43e-044922PF01608
DomainI_LWEQ

TLN1 TLN2

1.43e-044922PS50945
DomainSec7_N

ARFGEF2 ARFGEF1

1.43e-044922IPR032691
DomainSec7_N

ARFGEF2 ARFGEF1

1.43e-044922PF12783
DomainFERM_f0

TLN1 TLN2

1.43e-044922IPR032425
DomainDCB

ARFGEF2 ARFGEF1

1.43e-044922PF16213
DomainArfGap

ARFGAP2 AGAP5 AGAP9

3.85e-0429923SM00105
DomainARFGAP

ARFGAP2 AGAP5 AGAP9

3.85e-0429923PS50115
DomainArfGap

ARFGAP2 AGAP5 AGAP9

3.85e-0429923PF01412
DomainArfGAP

ARFGAP2 AGAP5 AGAP9

3.85e-0429923IPR001164
DomainVinculin/catenin

TLN1 TLN2

4.96e-047922IPR006077
DomainInsulin_GF-bd_Cys-rich_CS

CCN6 CCN5

1.28e-0311922IPR017891
DomainIGFBP_N_1

CCN6 CCN5

1.53e-0312922PS00222
DomainIRS

TLN1 TLN2

2.10e-0314922PF02174
DomainIRS_PTB

TLN1 TLN2

2.10e-0314922IPR002404
DomainPLAC

ADAMTS19 ADAMTS6

2.10e-0314922PF08686
Domain-

ARFGEF2 ARFGEF1

2.42e-03159221.10.1000.11
DomainIBN_N

XPO6 XPO7

2.42e-0315922PF03810
DomainSec7

ARFGEF2 ARFGEF1

2.42e-0315922PF01369
DomainSec7_alpha_orthog

ARFGEF2 ARFGEF1

2.42e-0315922IPR023394
DomainChemokine_rcpt

CCR5 CCR6

2.75e-0316922IPR000355
DomainIBN_N

XPO6 XPO7

2.75e-0316922SM00913
DomainSEC7

ARFGEF2 ARFGEF1

2.75e-0316922PS50190
DomainSec7

ARFGEF2 ARFGEF1

2.75e-0316922SM00222
DomainSec7_dom

ARFGEF2 ARFGEF1

2.75e-0316922IPR000904
DomainIB

CCN6 CCN5

3.49e-0318922SM00121
DomainPLAC

ADAMTS19 ADAMTS6

3.89e-0319922PS50900
DomainPLAC

ADAMTS19 ADAMTS6

3.89e-0319922IPR010909
DomainIGFBP

CCN6 CCN5

4.30e-0320922PF00219
DomainIGFBP-like

CCN6 CCN5

4.30e-0320922IPR000867
DomainIGFBP_N_2

CCN6 CCN5

4.30e-0320922PS51323
Pubmed

Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.

NOTCH2NLB NOTCH2NLA NOTCH2NLC NOTCH2

5.45e-11496432330268
Pubmed

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.

NOTCH2NLB NOTCH2NLA NOTCH2NLC NOTCH2

2.72e-10596429856954
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

IPO5 THADA XPO6 FDPS ARFGEF1 RNF213 PRKDC XPO7

4.50e-0818396823956138
Pubmed

Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex.

NOTCH2NLB NOTCH2NLA NOTCH2NLC

8.14e-08496329561261
Pubmed

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.

NOTCH2NLB NOTCH2NLA NOTCH2NLC

2.03e-07596329856955
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

CLCN6 ZNF608 XPO6 SYNE1 TLN1 TLN2 AKAP11 KAT6B

2.20e-0722596812168954
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

ARFGAP2 THADA APBB2 ARFGEF2 ARFGEF1 RNF213 CEP131 GPRC5C PRKDC PCDH10 NOTCH2 XPO7

1.60e-06777961235844135
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

CCN6 CCN5 ADAMTS19 ADAMTS6 THSD7B

2.14e-067596520637190
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

TKT PSMA4 TLN1 RNF213 PRKDC UQCRC1

3.10e-0614496635681168
Pubmed

Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.

TLN1 TLN2 LIMS2

7.26e-061496319652092
Pubmed

Molecular characterization of CCR6: involvement of multiple domains in ligand binding and receptor signaling.

CCR5 CCR6

7.54e-06296215591779
Pubmed

Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.

ARFGEF2 ARFGEF1

7.54e-06296223918382
Pubmed

Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.

ARFGEF2 ARFGEF1

7.54e-06296217360629
Pubmed

Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses.

CCR5 CCR6

7.54e-06296223565250
Pubmed

Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.

ARFGEF2 ARFGEF1

7.54e-06296210716990
Pubmed

Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.

ARFGEF2 ARFGEF1

7.54e-06296218203920
Pubmed

Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes.

CCR5 CCR6

7.54e-06296211751947
Pubmed

Novel CD8 T cell alloreactivities in CCR5-deficient recipients of class II MHC disparate kidney grafts.

IGHM CCR5

7.54e-06296225172484
Pubmed

Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.

ARFGEF2 ARFGEF1

7.54e-06296218417613
Pubmed

Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.

TLN1 TLN2

7.54e-06296226822056
Pubmed

Extracellular rigidity sensing by talin isoform-specific mechanical linkages.

TLN1 TLN2

7.54e-06296226523364
Pubmed

Disruption of the ARID1B and ADAMTS6 loci due to a t(5;6)(q12.3;q25.3) in a patient with developmental delay.

ARID1B ADAMTS6

7.54e-06296225250687
Pubmed

New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.

TLN1 TLN2

7.54e-06296222306379
Pubmed

Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.

ARFGEF2 ARFGEF1

7.54e-06296210212200
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

THADA SYNE1 CECR2 THSD7B TANGO6

9.72e-0610296511214970
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SOX6 IPO5 USP2 SYNE1 APBB2 ARFGEF2 CUL9 TLN2 PRKDC UQCRC1 MERTK ZNF439 IMMT RECK

1.17e-051285961435914814
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

IPO5 ARID1B ARFGEF2 ARFGEF1 ALAS1 XPO7

1.34e-0518696633637726
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IPO5 SF3A1 TLN1 NUMA1 CUL9 PRKDC UQCRC1 IMMT ITPR3 XPO7

1.35e-05653961022586326
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

AGAP5 ARID1B ZNF608 FDPS CECR2 MED12L AKAP11 AGAP9 KAT6B

1.63e-0552996914621295
Pubmed

Transcriptional fates of human-specific segmental duplications in brain.

NOTCH2NLB NOTCH2NLA NOTCH2NLC

1.91e-051996330228200
Pubmed

Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.

TLN1 TLN2

2.26e-05396212422220
Pubmed

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.

ARFGEF2 ARFGEF1

2.26e-05396219332778
Pubmed

Abnormal chemokine receptor profile on circulating T lymphocytes from nonallergic asthma patients.

CCR5 CCR6

2.26e-05396225178112
Pubmed

Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications.

CCN6 CCN5

2.26e-05396220372786
Pubmed

Specific functions of BIG1 and BIG2 in endomembrane organization.

ARFGEF2 ARFGEF1

2.26e-05396220360857
Pubmed

AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.

ARFGEF2 ARFGEF1

2.26e-05396216866877
Pubmed

Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation.

CCR5 CCR6

2.26e-05396217404315
Pubmed

Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer.

CCN6 CCN5

2.26e-05396217406949
Pubmed

Critical role for mouse marginal zone B cells in PF4/heparin antibody production.

IGHM NOTCH2

2.26e-05396223460609
Pubmed

Glycogen formation via the pentose phosphate pathway in mice in vivo.

TKT RBKS

2.26e-05396213405914
Pubmed

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells.

TLN1 TLN2

2.26e-05396218792400
Pubmed

Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion.

TLN1 TLN2

2.26e-05396222665520
Pubmed

Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.

ARFGEF2 ARFGEF1

2.26e-05396231199673
Pubmed

An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.

TLN1 TLN2

2.26e-05396217202407
Pubmed

Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons.

IGHM PRKDC

2.26e-05396211452126
Pubmed

Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.

ARFGEF2 ARFGEF1

2.26e-05396227162341
Pubmed

The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).

ARFGEF2 ARFGEF1

2.26e-05396223386609
Pubmed

Mechanotransduction in talin through the interaction of the R8 domain with DLC1.

TLN1 TLN2

2.26e-05396230028837
Pubmed

Vinculin and talin: focus on the myocardium.

TLN1 TLN2

2.26e-05396219952892
Pubmed

Do DNA repair genes OGG1, XRCC3 and XRCC7 have an impact on susceptibility to bladder cancer in the North Indian population?

PRKDC OGG1

2.26e-05396219815090
Pubmed

Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs.

IGHM PRKDC

2.26e-0539629021175
Pubmed

Talin depletion reveals independence of initial cell spreading from integrin activation and traction.

TLN1 TLN2

2.26e-05396219160486
Pubmed

Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.

TLN1 TLN2

2.26e-05396227816808
Pubmed

WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.

CCN6 CCN5

2.26e-0539629843955
Pubmed

A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.

ARFGEF2 ARFGEF1

2.26e-05396218832381
Pubmed

The effects of RANTES/CCR5 promoter polymorphisms on HIV disease progression in HIV-infected Koreans.

CCR5 CCR6

2.26e-05396218218038
Pubmed

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

TLN1 TLN2

2.26e-05396215494027
Pubmed

Vinculin controls talin engagement with the actomyosin machinery.

TLN1 TLN2

2.26e-05396226634421
Pubmed

Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy.

CCR5 CCR6

2.26e-05396231432181
Pubmed

Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen.

IGHM PRKDC

2.26e-05396237352357
Pubmed

Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy.

TLN1 TLN2

2.26e-05396228698364
Pubmed

Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.

ARFGEF2 ARFGEF1

2.26e-05396218003980
Pubmed

ABCE1 is a highly conserved RNA silencing suppressor.

STARD9 FDPS SF3A1 NUMA1 IMMT SDHB

2.26e-0520496625659154
Pubmed

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

IPO5 TKT PSMA4 PRKDC IMMT NOTCH2 XPO7

3.09e-0532096728685749
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

IPO5 XPO6 SF3A1 TLN1 MED12L ARFGEF2 TLN2 TNFAIP2 PRKDC

3.45e-0558296920467437
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

IPO5 THADA TKT STARD9 SYNE1 SF3A1 PSMA4 TLN1 NUMA1 TLN2 PRKDC UQCRC1 IMMT SDHB

3.65e-051425961430948266
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

IPO5 CLCN6 TKT SF3A1 TLN1 RNF213 ALAS1 UQCRC1 IMMT NOTCH2 SDHB TMPRSS11B TMED3 XPO7

4.43e-051451961430550785
Pubmed

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.

NUMA1 PRKDC

4.51e-0549629586635
Pubmed

Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation.

CCR5 PRKDC

4.51e-05496222392992
Pubmed

Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.

ARFGEF2 ARFGEF1

4.51e-05496211013081
Pubmed

B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection.

IGHM PRKDC

4.51e-05496217114442
Pubmed

Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.

ARFGEF2 ARFGEF1

4.51e-05496212606707
Pubmed

Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).

ARFGEF2 ARFGEF1

4.51e-05496212571360
Pubmed

Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx.

IGHM PRKDC

4.51e-05496223529621
Pubmed

Homeostatic regulation of intestinal villous epithelia by B lymphocytes.

IGHM PRKDC

4.51e-05496211884426
Pubmed

Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.

ARFGEF2 ARFGEF1

4.51e-05496222084092
Pubmed

Vinculin regulates assembly of talin: β3 integrin complexes.

TLN1 TLN2

4.51e-05496224446374
Pubmed

Impaired lung dendritic cell activation in CCR2 knockout mice.

CCR5 CCR6

4.51e-05496215466386
Pubmed

Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.

TLN1 TLN2

4.51e-05496230242097
Pubmed

Structural diversity in integrin/talin interactions.

TLN1 TLN2

4.51e-05496221134644
Pubmed

Endothelial cell talin1 is essential for embryonic angiogenesis.

TLN1 TLN2

4.51e-05496221081121
Pubmed

Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin.

TLN1 TLN2

4.51e-05496215581353
Pubmed

T lymphocyte recruitment into renal cell carcinoma tissue: a role for chemokine receptors CXCR3, CXCR6, CCR5, and CCR6.

CCR5 CCR6

4.51e-05496222079021
Pubmed

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

IPO5 WDR91 SUOX FDPS TLN1 TLN2 UQCRC1

4.62e-0534196729791485
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

IPO5 TKT SF3A1 IGHM TLN1 NUMA1 SCP2 UQCRC1 IMMT

4.77e-0560796939147351
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

THADA SSU72 XPO6 TLN1 ARFGEF2 CUL9 TLN2 CEP131 TNFAIP2 PRKDC NOTCH2 ITPR3

5.35e-051105961235748872
Pubmed

Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells.

CCR5 CCR6 PRKDC

7.07e-052996334678150
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

IPO5 ARID1B TKT SYNE1 TLN1 MED12L TRIM63 NOTCH2

7.26e-0549796823414517
Pubmed

Assignment of Na,K-ATPase beta 2-subunit gene (Atpb-2) to mouse chromosome 11.

ASGR1 ATP1B2

7.50e-0559621971252
Pubmed

Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.

TLN1 TLN2

7.50e-05596221670148
Pubmed

MyD88 is required for the formation of long-term humoral immunity to virus infection.

IGHM PRKDC

7.50e-05596217404295
Pubmed

Assignment of Amog (adhesion molecule on glia) gene to mouse chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17.

ASGR1 ATP1B2

7.50e-0559621699290
Pubmed

A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae.

IGHM PRKDC

7.50e-05596211920579
Pubmed

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.

IGHM PRKDC

7.50e-05596221300912
Pubmed

B cell production of tumor necrosis factor in response to Pneumocystis murina infection in mice.

IGHM PRKDC

7.50e-05596224002064
Pubmed

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.

TLN1 TLN2

7.50e-05596226821125
Pubmed

γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation.

CCR5 CCR6

7.50e-05596227569912
Pubmed

CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells.

CCR5 CCR6

7.50e-05596212960300
Pubmed

The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.

IGHM PRKDC

7.50e-05596212646649
Pubmed

Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction.

TLN1 TLN2

7.50e-05596219805288
InteractionFPR1 interactions

THADA DYM XPO6 ARFGEF2 ARFGEF1 RNF213 PRKDC XPO7

2.84e-07147898int:FPR1
InteractionOPALIN interactions

THADA DYM XPO6 ARFGEF2 ARFGEF1 RNF213 GPRC5C PRKDC XPO7

3.62e-07209899int:OPALIN
InteractionCD244 interactions

ARFGEF2 ARFGEF1 RNF213 TNFAIP2 IMMT

1.26e-0643895int:CD244
InteractionGPR17 interactions

THADA DYM XPO6 ARFGEF2 ARFGEF1 RNF213 TNFAIP2 PRKDC XPO7

4.45e-06283899int:GPR17
InteractionVASN interactions

THADA SF3A1 NOTCH2NLA ARFGEF2 PRKDC NOTCH2 XPO7

6.96e-06160897int:VASN
InteractionSIGLECL1 interactions

THADA DYM XPO6 ARFGEF2 ARFGEF1 RNF213

1.08e-05113896int:SIGLECL1
InteractionVSIG2 interactions

THADA DYM XPO6 XPO7

1.16e-0532894int:VSIG2
InteractionC3orf18 interactions

THADA DYM XPO6 ARFGEF2 PRKDC XPO7

1.20e-05115896int:C3orf18
InteractionFAM234A interactions

THADA XPO6 ARFGEF2 ARFGEF1 PRKDC XPO7

2.02e-05126896int:FAM234A
InteractionCCL3L1 interactions

WNT5A TLN1 TLN2 CCR5

2.10e-0537894int:CCL3L1
InteractionEDNRB interactions

THADA ARFGEF2 ARFGEF1 XPO7

2.60e-0539894int:EDNRB
InteractionNPTN interactions

THADA NBEAL1 XPO6 ARFGEF2 ARFGEF1 RNF213 TNFAIP2 XPO7

3.19e-05278898int:NPTN
InteractionGPR182 interactions

THADA DYM XPO6 ARFGEF2 ARFGEF1 RNF213 GPRC5C TNFAIP2 PRKDC XPO7

3.22e-054558910int:GPR182
InteractionMGARP interactions

THADA ARFGEF2 ARFGEF1 RNF213 TNFAIP2 PRKDC IMMT

5.74e-05222897int:MGARP
InteractionSUMO2 interactions

SOX6 IPO5 TKT SF3A1 TLN1 NUMA1 TRIM63 RNF213 ALAS1 PRKDC MERTK

5.79e-055918911int:SUMO2
InteractionCD40 interactions

THADA DYM XPO6 ARFGEF2 ARFGEF1 RNF213

6.00e-05153896int:CD40
InteractionMFSD4A interactions

THADA ARFGEF2 ARFGEF1 RNF213 TNFAIP2 IMMT XPO7

6.24e-05225897int:MFSD4A
InteractionCCN6 interactions

CCN6 APBB2 NOTCH2

7.66e-0519893int:CCN6
InteractionTMEM9B interactions

ARFGEF2 ARFGEF1 RNF213 TNFAIP2 NOTCH2

1.33e-04111895int:TMEM9B
InteractionLRRC25 interactions

THADA ARFGEF2 ARFGEF1 TNFAIP2 PRKDC XPO7

1.71e-04185896int:LRRC25
GeneFamilyCYR61/CTGF/NOV matricellular proteins

CCN6 CCN5

2.07e-0466821046
GeneFamilyArfGAPs

ARFGAP2 AGAP5 AGAP9

2.56e-0433683395
GeneFamilyExportins

XPO6 XPO7

2.89e-047682547
GeneFamilyCD molecules|C-C motif chemokine receptors

CCR5 CCR6

6.15e-04106821091
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP5 AGAP9

1.83e-03176821291
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS19 ADAMTS6

2.29e-031968250
CoexpressionGSE18281_SUBCAPSULAR_VS_PERIMEDULLARY_CORTICAL_REGION_OF_THYMUS_UP

DYM SUOX SYNE1 SCP2 CCR6 MERTK RECK ITPR3

5.37e-07200928M7235
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANO2 ZNF608 ADAMTS6 THSD7B ATP1B2 PCDH10

3.04e-0618596616e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SOX6 ADAMTS6 TLN2 MERTK PCDH10 LIMS2

3.13e-061869662d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

USP2 ADAMTS6 STARD9 SYNE1 ADGRL3 LIMS2

4.49e-06198966c12e7511628db819a52959bb68580e27c00c2e41
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial|GW09 / Sample Type, Dataset, Time_group, and Cell type.

ADAMTS6 MPDZ GPRC5C NOTCH2

3.14e-05839647893ce9fbf34c6250dca9c265fe9b2d4cb889ade
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP2 FDPS ALAS1 PTPRU TMED3

3.46e-05171965fea6ef6bbfebea2dd0f0360c7db7a5e858f15958
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP2 FDPS ALAS1 PTPRU TMED3

3.46e-05171965f15594fd4d709920733de9376a391dedc62b65de
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX6 AKAP11 SRPX TNFAIP2 XPO7

3.86e-05175965085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCellCOVID-19_Moderate-B_intermediate|COVID-19_Moderate / disease group, cell group and cell class

ZNF608 ADAMTS6 IGHM CCR6 SP140

4.07e-0517796568e3d12a0c048a2d0f1b9680c7338a35855bba30
ToppCell10x5'v1-week_12-13-Lymphocytic_B-B_lineage-naive_B_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS6 IGHM CCR6 SP140 LIMS2

4.07e-05177965325c10674b18727ddd50bf088a9c6f4ef29aa809
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

WDR91 SUOX STARD9 CUL9 ITPR3

4.30e-0517996568511e87b12b8253de7771e5ccfc5869248b8450
ToppCellLeuk-UTI-Lymphocyte-B-B_intermediate|Leuk-UTI / Disease, Lineage and Cell Type

ZNF608 ADAMTS6 IGHM CCR6 SP140

4.30e-0517996501933f6fa94d7032ed403a6cae6985cafa820043
ToppCellCOVID-19_Moderate-B_intermediate|World / disease group, cell group and cell class

ZNF608 ADAMTS6 IGHM CCR6 SP140

4.41e-05180965bd81b87a6dc81e5ab4a6c948eb0c80f14401a6a7
ToppCellRA-07._Pericyte|RA / Chamber and Cluster_Paper

NBEAL1 APBB2 GPRC5C THSD7B ADGRL3

4.53e-051819658dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CECR2 ARFGEF1 MERTK ITPR3

4.53e-0518196522363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCellnormal_Lung-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

USP2 GPRC5C CCR6 ZNF439 PCDH10

4.65e-051829658dd79fef8f8463ad3194f9cc07c6cacf2c886304
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANO2 ADAMTS6 SRPX ADGRL3 LIMS2

4.77e-05183965c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANO2 ADAMTS6 THSD7B ATP1B2 PCDH10

5.16e-05186965fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS6 TLN2 PCDH10 ADGRL3 LIMS2

5.16e-0518696592092f11ecce22c14f244e42c499af0822977e6f
ToppCellwk_20-22-Hematologic_Lymphocytic-B-CD5+_CCL22-_mature_B|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ADAMTS6 IGHM KBTBD8 CCR6 SP140

5.16e-051869653941d4af5f2b209d71f59d7d920f2322131b4a0c
ToppCell10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-naive_B_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS6 IGHM CCR6 SP140 LIMS2

5.43e-0518896531129152386e9aba16f749d78da12a08b916e6f8
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP2 STARD9 TLN1 MERTK ATP1B2

5.56e-05189965d69b7a01dd4d6ad043bb6210e9ab34b49578389c
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SOX6 ADAMTS6 MERTK PCDH10 LIMS2

5.56e-05189965c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP2 STARD9 TLN1 MERTK ATP1B2

5.56e-051899652b5f1b4f173a224342ea4f10b193ee33b7662699
ToppCell3'-Adult-Distal_Rectal-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP2 STARD9 TLN1 MERTK ATP1B2

5.56e-0518996543e131458d8a4b120f7a5fb3d0c5650abded15f6
ToppCellBAL-Control-Lymphocyte-B-B_cell|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

WDR91 ZNF608 IGHM MED12L ITPR3

5.70e-05190965da7341a8a423e5fe4d8e733d8e50c10a3318ac1c
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SOX6 ADAMTS6 MERTK PCDH10 LIMS2

5.70e-05190965aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellBAL-Control-Lymphocyte-B-B_cell-B_cell|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

WDR91 ZNF608 IGHM MED12L ITPR3

5.70e-0519096542312f7d79fe889397d32910b625793e2535cc26
ToppCellBAL-Control-Lymphocyte-B-B_cell-B_cell-B_activate-7|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

WDR91 ZNF608 IGHM MED12L ITPR3

5.70e-05190965682418a7a2096743112eae3790d40e7e600612c0
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SOX6 ADAMTS6 MERTK PCDH10 LIMS2

5.85e-051919654b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell10x5'v1-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS6 IGHM CCR6 SP140 LIMS2

5.99e-051929655d6569b0f879729aa89d4498c9c886ac9050be13
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ZNF608 ADAMTS6 THSD7B ATP1B2

5.99e-05192965bf1943715085c4124b1675888b0615c9500ec888
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-B_cell-B_cell-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ARID1B IGHM CCR6 AGAP9 SP140

6.30e-051949659a99abc65e7509e7ae8fb392f5ee4b2a83128072
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANO2 ZNF608 ADAMTS6 ADGRL3 LIMS2

6.30e-0519496571ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANO2 ADAMTS6 SRPX ADGRL3 LIMS2

6.30e-05194965fc2e0081005c0c496e41197a2d06e4a37708221f
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANO2 ZNF608 ADAMTS6 SYNE1 LIMS2

6.30e-0519496540842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NOTCH2NLB NOTCH2NLA SIRPB1 TNFAIP2 NOTCH2

6.30e-05194965dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_mature|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ZCCHC18 ADAMTS6 IGHM CCR6 SP140

6.61e-051969654b9eb163b9dbbf5eebb160f6554f6f28cb234d31
ToppCellPBMC-Control-cDC_3|Control / Compartment, Disease Groups and Clusters

IPO5 ARFGEF2 AKAP11 NOTCH2 LRRC74B

6.61e-0519696509d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TKT FDPS SCP2 ALAS1 TMED3

6.77e-05197965ad6f047d003c08413264f39a30ba0f7639a257cd
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

SSU72 TKT PSMA4 SCP2 ALAS1

6.77e-0519796507aee25e17dbb71e49f7da9fd9ed2537f4a72d82
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

USP2 ADAMTS6 STARD9 SYNE1 ADGRL3

6.77e-05197965ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial-Astrocyte|GW19 / Sample Type, Dataset, Time_group, and Cell type.

NOTCH2NLB ADAMTS6 RNF213 ATP1B2 NOTCH2

6.93e-05198965bfad1c51cf884ff7ce89f8278820800582541dc7
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

NOTCH2NLB ADAMTS6 RNF213 ATP1B2 NOTCH2

6.93e-051989656372e65242236c497d9b3be147092897c1609d22
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SOX6 CCN6 NBEAL1 GPRC5C PTPRU

6.93e-05198965b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2|LPS_only / Treatment groups by lineage, cell group, cell type

TKT FDPS SCP2 ALAS1 TMED3

6.93e-051989656b6572deeca98ccb015f2aa3c5ce27de44445f74
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TKT FDPS SCP2 ALAS1 TMED3

6.93e-05198965d12f37527399038a8f030b45b176bda5c7c8a7ad
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

USP2 ADAMTS6 STARD9 SYNE1 LIMS2

6.93e-0519896522e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCellLPS_IL1RA-Epithelial_alveolar|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TKT FDPS SCP2 ALAS1 TMED3

7.10e-051999655b140ac88ebc25ce397ae577e48f3e271faf46e7
ToppCellSepsis-Leuk-UTI-Lymphocyte-B-B_intermediate|Leuk-UTI / Disease, condition lineage and cell class

ZNF608 ADAMTS6 IGHM CCR6 SP140

7.10e-05199965e3edf3bcb381dbcf0092bdc2ee93ba852d32af3f
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ZNF608 MPDZ RNF213 ADGRL3 LIMS2

7.27e-05200965dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellNeuronal-Inhibitory|Neuronal / cells hierarchy compared to all cells using T-Statistic

SOX6 ZNF608 ADAMTS6 THSD7B ATP1B2

7.27e-052009659ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

SOX6 ADAMTS6 MERTK PCDH10 LIMS2

7.27e-0520096565b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial-Astrocyte|GW19 / Sample Type, Dataset, Time_group, and Cell type.

NOTCH2NLB ADAMTS6 RNF213 ATP1B2 NOTCH2

7.27e-052009657c66953ff6d8f16f4decd23c85232990d2d8c6c4
ToppCellControl-Control-Lymphocyte-B-B_naive|Control / Disease, condition lineage and cell class

ZNF608 IGHM APBB2 CCR6 SP140

7.27e-0520096515e4b9956b9a0c2e6927a802e86e1cb4bb18b89a
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

ADAMTS6 TLN2 PCDH10 ADGRL3 LIMS2

7.27e-05200965e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SOX6 ADAMTS6 MERTK PCDH10 LIMS2

7.27e-05200965b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellControl-Classical_Monocyte-|Classical_Monocyte / Disease condition and Cell class

AGAP5 MED12L RBKS ATP1B2

1.80e-041309644433b40b099845f113993b6ecf85ec594b4b9219
ToppCellSevere-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ZNF608 IGHM APBB2 LIMS2

2.73e-04145964a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANO2 ADAMTS6 SRPX LIMS2

3.11e-041509644f31867cb85253ff6d22f3b02ef972a42cb41123
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CCN5 ZCCHC18 TLN2 PCDH10

3.35e-041539641524557514668f515ac1bbe847611f564b265b42
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ZCCHC18 IGHM CUL9 SP140

3.43e-04154964e16f200391537aa1002b0079481b94e1fb86b9ad
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SOX6 CCN5 ADAMTS6 TNFAIP2

3.52e-04155964a16e3a72badafa78a3efc4f4ab62396f0ce99d1e
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-12|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZCCHC18 IGHM ZNF439 LIMS2

3.61e-041569647ece590fd8f29382e349dd0e5e016d2926aeb518
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

SYNE1 IGHM RNF213 ITPR3

3.61e-04156964afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellControl-Endothelial-Epi-like|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

WDR91 ACADS RBKS HARBI1

3.69e-041579644d02c50d5d1b892ea241e98724386d8a5a156a46
ToppCellControl-Endothelial-Epi-like-Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

WDR91 ACADS RBKS HARBI1

3.69e-041579642c369660c752c0fb3bd798a561d3359e2f9aa983
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCN5 CLCN6 IGHM CCR6

3.78e-0415896441cf950983f47a9e55d56041b301006b42853b37
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|356C / Donor, Lineage, Cell class and subclass (all cells)

ASGR1 WNT5A SIRPB1 HARBI1

3.87e-0415996424f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SOX6 AGAP5 ASGR1 TMPRSS11B

4.06e-041619648ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCellHealthy_Control-Lymphoid-B-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

ZCCHC18 IGHM MED12L CCR6

4.26e-04163964d84bd41b4494c7d5c7f88d511bfe481fb12f079d
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

STARD9 WNT5A RBKS THSD7B

4.26e-041639641e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCellHealthy_Control-Lymphoid-B|Healthy_Control / Condition, Lineage, Cell class and cell subclass

ZCCHC18 IGHM MED12L CCR6

4.26e-041639640f723ec2503afa1b3ebb0754972438ffb6e6179d
ToppCell10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS6 IGHM SP140 LIMS2

4.36e-0416496469b6566fb88c7449b7ab9056b57508cb6a1aa2af
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-Tregs|bone_marrow / Manually curated celltypes from each tissue

IGLV3-12 CCN6 EVX1 CCR6

4.46e-041659641ae1ad4e1fe19b6eefff0f9a03d58a384f169759
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGHM KBTBD8 CCR6 SP140

4.77e-04168964eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGHM KBTBD8 CCR6 SP140

4.77e-04168964063d0368d656962b335154c230bdcd9236e7c9ad
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

ANO2 SRPX PCDH10 LIMS2

4.77e-041689648c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGHM KBTBD8 CCR6 SP140

4.77e-04168964a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCell3'-Adult-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS6 KBTBD8 MED12L SIRPB1

4.88e-04169964203971cceeba150d0e8891c92662545e84c77837
ToppCellfacs-Tongue-nan-24m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCN5 TKT FDPS TNFAIP2

4.88e-041699640054f9bfd4d377c7fd94873c1308622051c59a8e
ToppCellURO-Lymphocyte-B-B_intermediate|URO / Disease, Lineage and Cell Type

ADAMTS6 IGHM CCR6 SP140

4.99e-04170964e11d1510518cedabeece96d4adbb90999e6326fa
ToppCellLPS-IL1RA-Lymphocytic_B-B_cells-B-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGHM KBTBD8 CCR6 SP140

4.99e-0417096492e0873f618b2fa60c4d555b10f234d5cbcf3325
ToppCellLPS-IL1RA-Lymphocytic_B-B_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGHM KBTBD8 CCR6 SP140

4.99e-04170964c181991f933b779f99afc3782f292306f209e2ac
ToppCellLPS-IL1RA-Lymphocytic_B|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGHM KBTBD8 CCR6 SP140

4.99e-0417096456284fbfd1e53f67c8c0b7fba64505a4002adba2
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF608 ADAMTS6 THSD7B ATP1B2

5.10e-04171964a5634b76476b8b2488a706bbab5141f7bd94631f
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 ALAS1 PTPRU TMED3

5.10e-0417196495e87987a2332fa646849fb0de785f1e0b8a07dd
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 ALAS1 PTPRU TMED3

5.10e-0417196436657e277aad75c4f157c1726c48e09b5836cf37
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SOX6 ATP1B2 NOTCH2 LIMS2

5.10e-041719644ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Immature_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHM KBTBD8 CCR6 SP140

5.21e-041729640bcb960c5ab0d3cbbdf6235b6f28327ea60ba3e3
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF608 ADAMTS6 WNT5A ATP1B2

5.21e-041729648b396d1e9173da104d467e42286379fe07cee257
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STARD9 CUL9 OPLAH TANGO6

5.21e-041729643b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF608 SYNE1 ARFGEF1 XPO7

5.21e-04172964d354424c1f861b6607dfd63b9724f4c237b30275
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMEM175 CCR5 TNFAIP2 SP140

5.32e-0417396420f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCellMild/Remission-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ARID1B IGHM APBB2 LIMS2

5.32e-04173964694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF608 ADAMTS6 THSD7B ATP1B2

5.44e-04174964fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCellInfluenza_Severe-B_intermediate|Influenza_Severe / Disease group and Cell class

IGHM MED12L CCR6 LIMS2

5.44e-041749644276bdaac53aebd3084323a90ecde572d3177446
ToppCellLPS-antiTNF-Lymphocytic_B|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGHM KBTBD8 CCR6 SP140

5.44e-04174964cc493654ea3517bc6a145c7f787f304929636f86
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 ADAMTS6 WNT5A THSD7B

5.44e-04174964cc4c7f00a25a7814b52d4599166615daa140cc31
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGHM KBTBD8 CCR6 SP140

5.44e-041749649eb3504f9340517ef5d056503044fbdb9ffeb714
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGHM KBTBD8 CCR6 SP140

5.44e-04174964b4c2d1c029fcd0d4926aa79a5b789c713919dcf3
ComputationalGenes in the cancer module 8.

IPO5 ASGR1 FDPS PSMA4 SCP2 PRKDC IMMT SDHB ITPR3 TMED3

1.32e-044216210MODULE_8
ComputationalB lymphoma expression clusters.

SOX6 USP2 IGHM MED12L TNFAIP2 SP140

2.08e-04149626MODULE_361
ComputationalGenes in the cancer module 17.

FDPS SF3A1 PSMA4 SCP2 PRKDC IMMT SDHB ITPR3 TMED3

2.29e-04366629MODULE_17
ComputationalNeighborhood of DEAF1

PRKDC IMMT SDHB XPO7

3.15e-0457624MORF_DEAF1
ComputationalNeighborhood of PPP1CC

IPO5 PRKDC UQCRC1 IMMT SDHB XPO7

3.73e-04166626MORF_PPP1CC
ComputationalGenes in the cancer module 145.

SOX6 USP2 IGHM MED12L TNFAIP2

4.35e-04111625MODULE_145
ComputationalNeighborhood of CUL1

XPO6 PSMA4 IMMT XPO7

7.70e-0472624MORF_CUL1
ComputationalNeighborhood of CDC16

PRKDC IMMT SDHB XPO7

8.98e-0475624MORF_CDC16
ComputationalGenes in the cancer module 18.

IPO5 FDPS PSMA4 SRPX PRKDC ATP1B2 OGG1 ITPR3 TMED3

1.04e-03451629MODULE_18
ComputationalGenes in the cancer module 188.

SOX6 USP2 IGHM MED12L TNFAIP2

1.21e-03139625MODULE_188
Diseasebeta-hydroxybutyric acid measurement

THSD7B MERTK

1.37e-046902EFO_0010465
Diseasesystolic blood pressure, alcohol consumption measurement

SOX6 CLCN6 EVX1

4.04e-0447903EFO_0006335, EFO_0007878
Diseasecerebral palsy (implicated_via_orthology)

AGAP5 AGAP9

4.07e-0410902DOID:1969 (implicated_via_orthology)
Diseaseinsulin sensitivity measurement, response to polyunsaturated fatty acid supplementation

TLN2 PTPRU

4.97e-0411902EFO_0004471, EFO_0009131
Diseaseobesity (implicated_via_orthology)

THADA MED12L SCP2 NOTCH2 ITPR3

5.21e-04215905DOID:9970 (implicated_via_orthology)
Diseaseunipolar depression, bipolar disorder

SOX6 ACADS STARD9 SYNE1

1.35e-03156904EFO_0003761, MONDO_0004985
DiseaseHeadache, HbA1c measurement

NBEAL1 TKT

1.86e-0321902EFO_0004541, HP_0002315
DiseaseHereditary Paraganglioma-Pheochromocytoma Syndrome

MERTK SDHB

2.23e-0323902C1708353
DiseaseNeoplasm Invasiveness

TKT TLN1 RECK NOTCH2

2.46e-03184904C0027626

Protein segments in the cluster

PeptideGeneStartEntry
SLSCQMAALQGNGSE

ASGR1

136

P07306
RNGLNCAAVMRVALS

FAM200B

626

P0CF97
ALQSIQNMRGNAHCV

AGAP9

511

Q5VTM2
AGNVSEAVQAACMLR

APBB2

691

Q92870
SRGCASTGVIMSVNN

ACADS

106

P16219
VVRCIAQMVNSQAAN

ARFGEF1

1256

Q9Y6D6
SQGTLACSASDQMRR

EVX1

171

P49640
IMSQRCNNRTQCAVV

ADGRL3

86

Q9HAR2
CIAQMVNSQAANIRS

ARFGEF2

1206

Q9Y6D5
VTAANLGKMNRSCQS

CCR6

276

P51684
GMNITVLRSQCDAAS

AKAP11

206

Q9UKA4
QLRCMQVGGNANATA

ARFGAP2

76

Q8N6H7
AAAVMQAAANSAQSR

ARID1B

1016

Q8NFD5
CSRANNTMGINSLIA

ANO2

291

Q9NQ90
LNNCSSSNRLDQAMQ

CCR5

266

P51681
NAMASLQGCETLNAA

CECR2

1261

Q9BXF3
SAQCGLGQQMRTVQC

ADAMTS6

1031

Q9UKP5
INRQSRTTCVNANMG

NBEAL1

476

Q6ZS30
KNRCQNGGTCVAQAM

NOTCH2NLA

31

Q7Z3S9
NALFSCISRNEMGSV

RECK

136

O95980
MQSRQVACTQQLSNG

ADAMTS19

996

Q8TE59
MLSSGASCAAAAQRN

ITPR3

1551

Q14573
TCSACRVQGRNADNM

KAT6B

271

Q8WYB5
LLNSVMGQRNCDCSV

LRRC9

586

Q6ZRR7
ANQCVQAARLGAMTS

RBKS

56

Q9H477
NRCQNGGTCVAQAML

NOTCH2NLB

71

P0DPK3
NRCQNGGTCVAQAML

NOTCH2

71

Q04721
MSDALANAVCQRCQA

LIMS2

6

Q7Z4I7
CENANTSLGRRMSVN

MED12L

666

Q86YW9
MNVTRNTAFNLTCQA

MERTK

206

Q12866
LAAQMNQRGSSVFCK

ALAS1

111

P13196
LCSSLRMNGDQNSDV

FDPS

61

P14324
GANQSMNVTCAGKRD

ATP1B2

191

P14415
SQASMSRCVANVTEA

HARBI1

96

Q96MB7
QVMSQRAISFAGCTA

OR2T7

76

P0C7T2
ANSIGAMNNSDTRIA

OR52B6

16

Q8NGF0
AMNNSDTRIAGCFLT

OR52B6

21

Q8NGF0
MLRACQLSGVTAAAQ

IMMT

1

Q16891
CSSNNNIARITGMVE

OGG1

146

O15527
VMSQRAISFAGCTAQ

OR2T27

86

Q8NH04
TNRAQSAGMDLFSNC

PCDH10

926

Q9P2E7
CGDTSLNNMQRQLAL

IPO5

266

O00410
KNRCQNGGTCVAQAM

NOTCH2NLC

31

P0DPK4
MAASVVCRAATAGAQ

UQCRC1

1

P31930
VATAQMARITCGGNN

IGLV3-12

31

A0A075B6K2
SNTNGCTQRLGMTAS

KBTBD8

271

Q8NFY9
NAGQNASFQCMAAGR

PTPRU

201

Q92729
ANSQVMGSANSTLRA

GPRC5C

396

Q9NQ84
RTCGMGISNRVTNEN

CCN6

221

O95389
GISNRVTNENSNCEM

CCN6

226

O95389
LGECRQMSSSSQIGN

CLCN6

396

P51797
HRGLTFQQNASSMCV

IGHM

201

P01871
TNCLAALANMSAQFR

DYM

461

Q7RTS9
TTCGLGMATRVSNQN

CCN5

206

O76076
LMLNTEGCSSAARNG

CUL9

856

Q8IWT3
NRSNKGAVGNCVTTM

CEP131

171

Q9UPN4
ATCIGNNSAAAVSML

PSMA4

161

P25789
GAQALCAALTVNQAM

LRRC74B

151

Q6ZQY2
QGRQFCSTQAALQAM

NUMA1

956

Q14980
LGRQQAMAQSLSQCS

OTP

226

Q5XKR4
ISSCMENFNLGRASV

THADA

141

Q6YHU6
VNSRMGCQATQLTSR

SYNE1

3671

Q8NF91
ACAASQGCMNNVTLG

OPLAH

1096

O14841
NDTIISGMNCNGSAA

SLC12A1

446

Q13621
QGLTLSNVARCSSMD

STARD9

3501

Q9P2P6
TCAAMNVNVGVRTAA

SRPX

316

P78539
NNNCATGSTALFMAR

SCP2

91

P22307
SGSMARTQQAAQANI

SF3A1

506

Q15459
LSSINNMGLNSCRNE

SOX6

526

P35712
ALQSIQNMRGNAHCV

AGAP5

466

A6NIR3
NNCISMLVAGNDRVQ

TRIM63

171

Q969Q1
PMRAENQANVTCQVS

SIRPB1

261

O00241
QSAVGMLRDQNESCT

RNF213

3541

Q63HN8
NVIANINNCLSFRMS

TNFAIP2

421

Q03169
AGEGIQCSQRMLSFS

TMEM175

26

Q9BSA9
AGMSSEQVAQVLRQC

MPDZ

311

O75970
AASEMLTNNCCGRQV

TMPRSS11B

161

Q86T26
EQNMVSIAVGCATRN

TKT

366

P29401
RMAAISESNINLCGS

TKT

401

P29401
QFARANQAIQMACQS

TLN1

1466

Q9Y490
GNRVTALTQMESACV

TMED3

131

Q9Y3Q3
MAARQAVGSGAQETC

TANGO6

1

Q9C0B7
NESVSRAMCALLNSG

SLFN12

41

Q8IYM2
VSAAGVVNAMSRACR

WNT5A

141

P41221
MNGILAQDSACSQRA

PRKDC

3771

P78527
MASITACVGNSRQQN

ZCCHC18

1

P0CG32
VASQQVAAQASASGM

ZNF608

1491

Q9ULD9
LGINNQSNLTDMRCR

XPO7

651

Q9UIA9
GSSMAQLLTCAAQGN

TLN2

1101

Q9Y4G6
QACGTMDTVDIANNS

SP140

476

Q13342
TLQCAGNRRSEMTQV

SUOX

261

P51687
TRQVSCTRSDGQNAM

THSD7B

301

Q9C0I4
ARKMASVNGSSQNCV

XPO6

286

Q96QU8
CAMNINGGNTLACTR

SDHB

101

P21912
LAGLRNLGNTCFMNS

USP2

266

O75604
ELAMVCSQRNASLSQ

WDR91

241

A4D1P6
LRVAVVCSSNQNRSM

SSU72

6

Q9NP77
ALRNDSACNPVMATQ

ZP4

216

Q12836
CEVGLGNSSSNMNIR

ZNF439

126

Q8NDP4