Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein antigen binding

SIRPB1 SIRPA ITGA4 SIRPG

5.35e-0716854GO:1990405
GeneOntologyMolecularFunctioncomplement binding

CR1 CR1L CR2 ITGB2

1.00e-0532854GO:0001848
GeneOntologyMolecularFunctioncomplement component C3b binding

CR1 CR1L ITGB2

1.59e-0512853GO:0001851
GeneOntologyMolecularFunctioncomplement component C3b receptor activity

CR1 CR1L

1.79e-052852GO:0004877
GeneOntologyMolecularFunctioncomplement component C4b receptor activity

CR1 CR1L

1.79e-052852GO:0001861
GeneOntologyMolecularFunctioncomplement receptor activity

CR1 CR1L CR2

2.62e-0514853GO:0004875
GeneOntologyMolecularFunctioncell adhesion molecule binding

FLNA FLNB ITGA11 CCT8 KDR SIRPB1 SIRPA ITGA4 ITGB2 CNGA3 SIRPG

4.61e-055998511GO:0050839
GeneOntologyMolecularFunctioncomplement component C4b binding

CR1 CR1L

5.36e-053852GO:0001855
GeneOntologyMolecularFunctionprotein binding involved in heterotypic cell-cell adhesion

SIRPB1 SIRPA SIRPG

5.80e-0518853GO:0086080
GeneOntologyMolecularFunctionimmunoglobulin receptor binding

FLNA JCHAIN CR2

9.37e-0521853GO:0034987
GeneOntologyMolecularFunctionopsonin binding

CR1 CR1L ITGB2

1.60e-0425853GO:0001846
GeneOntologyMolecularFunctioncell adhesion mediator activity

ITGA11 SIRPB1 SIRPA SIRPG

3.11e-0476854GO:0098631
GeneOntologyMolecularFunctionopsonin receptor activity

CR1 CR1L

4.93e-048852GO:0001847
GeneOntologyMolecularFunctionantigen binding

JCHAIN SIRPB1 SIRPA ITGA4 SIRPG

1.31e-03190855GO:0003823
GeneOntologyMolecularFunctionphosphoprotein binding

IGF2R SIRPB1 SIRPA SIRPG

1.57e-03117854GO:0051219
GeneOntologyMolecularFunction5S rRNA binding

TST RPL5

1.58e-0314852GO:0008097
GeneOntologyMolecularFunctionribonucleoprotein complex binding

CPEB2 STRAP LEMD3 CPEB4 PRMT3

1.87e-03206855GO:0043021
GeneOntologyMolecularFunctionsnRNP binding

STRAP LEMD3

2.07e-0316852GO:0070990
GeneOntologyMolecularFunctioncell-cell adhesion mediator activity

SIRPB1 SIRPA SIRPG

2.24e-0361853GO:0098632
GeneOntologyMolecularFunctionmRNA regulatory element binding translation repressor activity

CPEB2 CPEB4

2.34e-0317852GO:0000900
GeneOntologyMolecularFunctionactin filament binding

FLNA FLNB ABLIM1 CAPZA2 ABLIM3

2.85e-03227855GO:0051015
GeneOntologyMolecularFunctionprotein phosphorylated amino acid binding

SIRPB1 SIRPA SIRPG

3.19e-0369853GO:0045309
GeneOntologyBiologicalProcessnegative regulation of I-kappaB phosphorylation

SIRPB1 SIRPA SIRPG

2.69e-074853GO:1903720
GeneOntologyBiologicalProcessnegative regulation of macrophage inflammatory protein 1 alpha production

SIRPB1 SIRPA SIRPG

6.71e-075853GO:0071641
GeneOntologyBiologicalProcessnegative regulation of humoral immune response

CR1 CR1L CR2 SPINK5

9.93e-0719854GO:0002921
GeneOntologyBiologicalProcessregulation of macrophage inflammatory protein 1 alpha production

SIRPB1 SIRPA SIRPG

3.73e-068853GO:0071640
GeneOntologyBiologicalProcessnegative regulation of complement activation, classical pathway

CR1 CR1L CR2

3.73e-068853GO:0045959
GeneOntologyBiologicalProcesspositive regulation of cell adhesion

FLNA FBLN2 EFNB2 DOCK8 KDR SIRPB1 ACTL6A SIRPA ITGA4 CR1 ITGB2 SIRPG

4.35e-065798512GO:0045785
GeneOntologyBiologicalProcessregulation of complement activation

C6 CR1 CR1L CR2

4.38e-0627854GO:0030449
GeneOntologyBiologicalProcessregulation of humoral immune response

C6 CR1 CR1L CR2 SPINK5

4.82e-0660855GO:0002920
GeneOntologyBiologicalProcessnegative regulation of chemokine (C-C motif) ligand 5 production

SIRPB1 SIRPA SIRPG

5.57e-069853GO:0071650
GeneOntologyBiologicalProcessmacrophage inflammatory protein-1 alpha production

SIRPB1 SIRPA SIRPG

5.57e-069853GO:0071608
GeneOntologyBiologicalProcesspositive regulation of leukocyte cell-cell adhesion

EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA ITGA4 CR1 ITGB2 SIRPG

6.31e-06317859GO:1903039
GeneOntologyBiologicalProcessregulation of I-kappaB phosphorylation

SIRPB1 SIRPA SIRPG

7.94e-0610853GO:1903719
GeneOntologyBiologicalProcessregulation of complement activation, classical pathway

CR1 CR1L CR2

7.94e-0610853GO:0030450
GeneOntologyBiologicalProcessnegative regulation of humoral immune response mediated by circulating immunoglobulin

CR1 CR1L CR2

1.45e-0512853GO:0002924
GeneOntologyBiologicalProcesscellular response to interleukin-12

SIRPB1 SIRPA SIRPG

1.87e-0513853GO:0071349
GeneOntologyBiologicalProcessmonocyte extravasation

SIRPB1 SIRPA SIRPG

1.87e-0513853GO:0035696
GeneOntologyBiologicalProcessnegative regulation of complement activation

CR1 CR1L CR2

2.38e-0514853GO:0045916
GeneOntologyBiologicalProcessregulation of cell adhesion

FLNA FBLN2 EFNB2 DOCK8 KDR SIRPB1 ACTL6A SIRPA ITGA4 CR1 MDGA1 ITGB2 SPINK5 SIRPG

2.41e-059278514GO:0030155
GeneOntologyBiologicalProcesscellular extravasation

SIRPB1 SIRPA ITGA4 ITGB2 SIRPG

2.67e-0585855GO:0045123
GeneOntologyBiologicalProcessregulation of chemokine (C-C motif) ligand 5 production

SIRPB1 SIRPA SIRPG

2.97e-0515853GO:0071649
GeneOntologyBiologicalProcesspositive regulation of cell-cell adhesion

EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA ITGA4 CR1 ITGB2 SIRPG

3.20e-05389859GO:0022409
GeneOntologyBiologicalProcesscomplement activation, classical pathway

C6 CR1 CR1L CR2

3.22e-0544854GO:0006958
GeneOntologyBiologicalProcesschemokine (C-C motif) ligand 5 production

SIRPB1 SIRPA SIRPG

3.64e-0516853GO:0071609
GeneOntologyBiologicalProcessnegative regulation of B cell mediated immunity

CR1 CR1L CR2

3.64e-0516853GO:0002713
GeneOntologyBiologicalProcessnegative regulation of immunoglobulin mediated immune response

CR1 CR1L CR2

3.64e-0516853GO:0002890
GeneOntologyBiologicalProcessresponse to interleukin-12

SIRPB1 SIRPA SIRPG

3.64e-0516853GO:0070671
GeneOntologyBiologicalProcesscell-substrate adhesion

FLNA ITGA11 FBLN2 KDR SIRPB1 SIRPA ITGA4 ITGB2 SIRPG

4.82e-05410859GO:0031589
GeneOntologyBiologicalProcesspositive regulation of activation of membrane attack complex

C6 CR1

5.02e-053852GO:0001970
GeneOntologyBiologicalProcessnegative regulation of interferon-beta production

SIRPB1 SIRPA SIRPG

7.32e-0520853GO:0032688
GeneOntologyBiologicalProcessregulation of leukocyte cell-cell adhesion

EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA ITGA4 CR1 ITGB2 SIRPG

9.33e-05447859GO:1903037
GeneOntologyBiologicalProcessI-kappaB phosphorylation

SIRPB1 SIRPA SIRPG

9.83e-0522853GO:0007252
GeneOntologyBiologicalProcessregulation of humoral immune response mediated by circulating immunoglobulin

CR1 CR1L CR2

9.83e-0522853GO:0002923
GeneOntologyBiologicalProcessregulation of activation of membrane attack complex

C6 CR1

1.00e-044852GO:0001969
GeneOntologyBiologicalProcesscellular response to type II interferon

FLNB PARP9 SIRPB1 SIRPA SIRPG

1.09e-04114855GO:0071346
GeneOntologyBiologicalProcesshumoral immune response mediated by circulating immunoglobulin

C6 CR1 CR1L CR2

1.25e-0462854GO:0002455
GeneOntologyBiologicalProcesscell-matrix adhesion

ITGA11 KDR SIRPB1 SIRPA ITGA4 ITGB2 SIRPG

1.26e-04270857GO:0007160
GeneOntologyBiologicalProcessregulation of cell-cell adhesion

EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA ITGA4 CR1 MDGA1 ITGB2 SIRPG

1.35e-045808510GO:0022407
GeneOntologyBiologicalProcessnegative regulation of nitric oxide biosynthetic process

SIRPB1 SIRPA SIRPG

1.45e-0425853GO:0045019
GeneOntologyBiologicalProcessnegative regulation of nitric oxide metabolic process

SIRPB1 SIRPA SIRPG

1.45e-0425853GO:1904406
GeneOntologyBiologicalProcessintegrin-mediated signaling pathway

FLNA ITGA11 ITGA4 ITGB2 ZNF304

1.62e-04124855GO:0007229
GeneOntologyBiologicalProcessleukocyte cell-cell adhesion

EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA ITGA4 CR1 ITGB2 SIRPG

1.75e-04486859GO:0007159
GeneOntologyBiologicalProcessphagocytosis, engulfment

SIRPB1 SIRPA ITGB2 SIRPG

1.89e-0469854GO:0006911
GeneOntologyBiologicalProcesspositive regulation of T cell activation

EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA CR1 SIRPG

1.96e-04290857GO:0050870
GeneOntologyBiologicalProcesscomplement activation

C6 CR1 CR1L CR2

2.00e-0470854GO:0006956
GeneOntologyBiologicalProcessactivation of membrane attack complex

C6 CR1

2.49e-046852GO:0001905
GeneOntologyBiologicalProcessresponse to type II interferon

FLNB PARP9 SIRPB1 SIRPA SIRPG

2.94e-04141855GO:0034341
GeneOntologyBiologicalProcessplasma membrane invagination

SIRPB1 SIRPA ITGB2 SIRPG

3.04e-0478854GO:0099024
GeneOntologyBiologicalProcessnegative regulation of phagocytosis

SIRPB1 SIRPA SIRPG

3.37e-0433853GO:0050765
GeneOntologyBiologicalProcesscell-cell adhesion

FLNA ITGA11 EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA ITGA4 CR1 MDGA1 ITGB2 ADGRL3 SIRPG

4.45e-0410778513GO:0098609
GeneOntologyBiologicalProcessmembrane invagination

SIRPB1 SIRPA ITGB2 SIRPG

4.61e-0487854GO:0010324
GeneOntologyBiologicalProcessnegative regulation of serine-type peptidase activity

CR1 SPINK5

4.62e-048852GO:1902572
GeneOntologyBiologicalProcessnegative regulation of serine-type endopeptidase activity

CR1 SPINK5

4.62e-048852GO:1900004
GeneOntologyBiologicalProcessnegative regulation of chemokine production

SIRPB1 SIRPA SIRPG

5.13e-0438853GO:0032682
GeneOntologyBiologicalProcesspositive regulation of cell activation

FLNA EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA CR1 SIRPG

5.27e-04449858GO:0050867
GeneOntologyBiologicalProcesspositive regulation of complement activation

C6 CR1

5.93e-049852GO:0045917
GeneOntologyBiologicalProcessregulation of T cell activation

EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA CR1 SPINK5 SIRPG

6.00e-04458858GO:0050863
GeneOntologyBiologicalProcessameboidal-type cell migration

ITGA11 SLC8A1 EFNB2 LEMD3 CAPN7 KDR ITGA4 ITGB2 OVOL2

6.14e-04577859GO:0001667
GeneOntologyBiologicalProcessphagocytosis, recognition

SIRPB1 SIRPA SIRPG

6.90e-0442853GO:0006910
GeneOntologyBiologicalProcessregulation of nitric oxide biosynthetic process

SIRPB1 SIRPA ITGB2 SIRPG

6.95e-0497854GO:0045428
GeneOntologyBiologicalProcessregulation of serine-type peptidase activity

CR1 SPINK5

7.39e-0410852GO:1902571
GeneOntologyBiologicalProcessregulation of serine-type endopeptidase activity

CR1 SPINK5

7.39e-0410852GO:1900003
GeneOntologyBiologicalProcessnegative regulation of cytoplasmic translation

CPEB2 CPEB4

7.39e-0410852GO:2000766
GeneOntologyBiologicalProcessnegative regulation of JNK cascade

SIRPB1 SIRPA SIRPG

7.40e-0443853GO:0046329
GeneOntologyBiologicalProcessnegative regulation of cytokine production involved in inflammatory response

SIRPB1 SIRPA SIRPG

7.40e-0443853GO:1900016
GeneOntologyBiologicalProcessregulation of nitric oxide metabolic process

SIRPB1 SIRPA ITGB2 SIRPG

7.80e-04100854GO:0080164
GeneOntologyBiologicalProcesspositive regulation of lymphocyte activation

EFNB2 DOCK8 SIRPB1 ACTL6A SIRPA CR1 SIRPG

1.06e-03385857GO:0051251
GeneOntologyBiologicalProcesscell morphogenesis

FLNA FLNB ABLIM1 EFNB2 COBL KDR PRMT3 CUL7 ITGA4 BRSK1 ITGB2 DCLK1 BRWD3

1.16e-0311948513GO:0000902
GeneOntologyBiologicalProcessnitric oxide biosynthetic process

SIRPB1 SIRPA ITGB2 SIRPG

1.19e-03112854GO:0006809
GeneOntologyBiologicalProcessendocardium development

KDR OVOL2

1.27e-0313852GO:0003157
GeneOntologyBiologicalProcessregulation of complement-dependent cytotoxicity

CR1 CR1L

1.27e-0313852GO:1903659
GeneOntologyBiologicalProcesshematopoietic progenitor cell differentiation

MLLT3 KDR SIRPB1 SIRPA SIRPG

1.34e-03197855GO:0002244
GeneOntologyBiologicalProcesscell recognition

DOCK8 CCT8 SIRPB1 SIRPA SIRPG

1.37e-03198855GO:0008037
GeneOntologyBiologicalProcessnegative regulation of type I interferon production

SIRPB1 SIRPA SIRPG

1.44e-0354853GO:0032480
GeneOntologyBiologicalProcessnitric oxide metabolic process

SIRPB1 SIRPA ITGB2 SIRPG

1.58e-03121854GO:0046209
GeneOntologyBiologicalProcessnegative regulation of protein metabolic process

CPEB2 FLNA SLC8A1 CPEB4 MLLT1 PRMT3 SIRPB1 SIRPA CR1 RPL5 SPINK5 SIRPG

1.63e-0310888512GO:0051248
GeneOntologyBiologicalProcesspositive regulation of immune system process

EFNB2 DOCK8 PARP9 SIRPB1 ACTL6A SIRPA C6 ITGA4 CR1 CR1L CR2 ITGB2 SIRPG

1.65e-0312428513GO:0002684
GeneOntologyBiologicalProcessreactive nitrogen species metabolic process

SIRPB1 SIRPA ITGB2 SIRPG

1.68e-03123854GO:2001057
GeneOntologyCellularComponentfocal adhesion

FLNA FLNB ITGA11 IGF2R EFNB2 RPS11 ITGA4 ITGB2 RPL5

6.39e-05431859GO:0005925
GeneOntologyCellularComponentcell-substrate junction

FLNA FLNB ITGA11 IGF2R EFNB2 RPS11 ITGA4 ITGB2 RPL5

7.88e-05443859GO:0030055
GeneOntologyCellularComponenttranscription elongation factor complex

ELOC AFF3 MLLT1 MLLT3

7.96e-0556854GO:0008023
GeneOntologyCellularComponentcell surface

FCRL2 ITGA11 IGF2R KDR SIRPB1 SIRPA ITGA4 LY75 CR1 CR1L MDGA1 CR2 ITGB2 SIRPG

1.46e-0411118514GO:0009986
GeneOntologyCellularComponentanchoring junction

FLNA FLNB KLHL24 ITGA11 SLC8A1 IGF2R EFNB2 RPS11 KDR ITGA4 ITGB2 RPL5 ADGRL3

1.51e-049768513GO:0070161
GeneOntologyCellularComponentexternal side of plasma membrane

FCRL2 ITGA11 KDR ITGA4 LY75 CR1 CR1L CR2 ITGB2

2.58e-04519859GO:0009897
GeneOntologyCellularComponentintegrin complex

ITGA11 ITGA4 ITGB2

2.96e-0432853GO:0008305
GeneOntologyCellularComponentaxon

FLNA KLHL24 SLC8A1 CPEB4 COBL ITGA4 BRSK1 MDGA1 CNGA3 DCLK1 ADGRL3

9.49e-048918511GO:0030424
GeneOntologyCellularComponentactin filament bundle

FLNA FLNB ABLIM1 ABLIM3

1.37e-03118854GO:0032432
GeneOntologyCellularComponentprotein complex involved in cell adhesion

ITGA11 ITGA4 ITGB2

1.79e-0359853GO:0098636
GeneOntologyCellularComponentficolin-1-rich granule membrane

SIRPA CR1 ITGB2

1.97e-0361853GO:0101003
GeneOntologyCellularComponentdistal axon

FLNA SLC8A1 CPEB4 COBL ITGA4 BRSK1 DCLK1

1.97e-03435857GO:0150034
HumanPhenoAccessory carpal bones

FLNA FLNB

3.13e-052292HP:0004232
HumanPhenoBipartite calcaneus

FLNA FLNB

3.13e-052292HP:0008127
DomainSushi

PAPPA2 C6 CR1 CR1L CR2

3.81e-0652855PF00084
DomainCCP

PAPPA2 C6 CR1 CR1L CR2

4.60e-0654855SM00032
DomainSUSHI

PAPPA2 C6 CR1 CR1L CR2

5.52e-0656855PS50923
DomainSushi_SCR_CCP_dom

PAPPA2 C6 CR1 CR1L CR2

6.03e-0657855IPR000436
DomainCEBP_ZZ

CPEB2 CPEB4

1.22e-044852IPR032296
DomainAbLIM_anchor

ABLIM1 ABLIM3

1.22e-044852PF16182
DomainYEATS

MLLT1 MLLT3

1.22e-044852IPR005033
DomainYEATS

MLLT1 MLLT3

1.22e-044852PS51037
DomainAbLIM_anchor

ABLIM1 ABLIM3

1.22e-044852IPR032402
DomainCEBP_ZZ

CPEB2 CPEB4

1.22e-044852PF16366
DomainRRM_7

CPEB2 CPEB4

1.22e-044852PF16367
DomainYEATS

MLLT1 MLLT3

1.22e-044852PF03366
DomainIntegrin_dom

ITGA11 ITGA4 ITGB2

1.95e-0425853IPR032695
DomainIg_V-set

IGSF10 FCRL2 KDR SIRPB1 SIRPA SIRPG

2.95e-04199856IPR013106
DomainIGv

IGSF10 SIRPB1 SIRPA SIRPG

3.80e-0475854SM00406
DomainVWFA

ITGA11 CLCA4 CPNE4 ITGB2

5.33e-0482854PS50234
DomainCalx_beta

FREM2 SLC8A1

5.63e-048852SM00237
DomainHP

ABLIM1 ABLIM3

5.63e-048852PS51089
Domain-

ABLIM1 ABLIM3

5.63e-0488521.10.950.10
DomainVHP

ABLIM1 ABLIM3

5.63e-048852PF02209
DomainVillin_headpiece

ABLIM1 ABLIM3

5.63e-048852IPR003128
DomainVHP

ABLIM1 ABLIM3

5.63e-048852SM00153
DomainVWA

ITGA11 CLCA4 CPNE4 ITGB2

5.84e-0484854SM00327
DomainCalx_beta

FREM2 SLC8A1

7.22e-049852IPR003644
DomainCalx-beta

FREM2 SLC8A1

7.22e-049852PF03160
Domain-

PAPPA2 IGSF10 FCRL2 FLNA FLNB KDR SIRPB1 SIRPA MDGA1 SIRPG

8.44e-0466385102.60.40.10
DomainIG_FLMN

FLNA FLNB

9.00e-0410852SM00557
DomainVWF_A

ITGA11 CLCA4 CPNE4 ITGB2

1.08e-0399854IPR002035
DomainFilamin

FLNA FLNB

1.10e-0311852PF00630
DomainFILAMIN_REPEAT

FLNA FLNB

1.10e-0311852PS50194
DomainFilamin/ABP280_rpt

FLNA FLNB

1.10e-0311852IPR001298
DomainFilamin/ABP280_repeat-like

FLNA FLNB

1.10e-0311852IPR017868
DomainIg-like_fold

PAPPA2 IGSF10 FCRL2 FLNA FLNB KDR SIRPB1 SIRPA MDGA1 SIRPG

1.36e-037068510IPR013783
DomainV-set

FCRL2 KDR SIRPB1 SIRPA SIRPG

1.53e-03184855PF07686
DomainFN_type2_col-bd

IGF2R LY75

1.80e-0314852IPR000562
DomainFN2_2

IGF2R LY75

1.80e-0314852PS51092
Domainfn2

IGF2R LY75

1.80e-0314852PF00040
DomainFN2_1

IGF2R LY75

1.80e-0314852PS00023
DomainFN2

IGF2R LY75

1.80e-0314852SM00059
DomainC1-set

SIRPB1 SIRPA SIRPG

1.91e-0354853PF07654
DomainIGc1

SIRPB1 SIRPA SIRPG

2.12e-0356853SM00407
DomainIg_C1-set

SIRPB1 SIRPA SIRPG

2.34e-0358853IPR003597
DomainIntegrin_alpha-2

ITGA11 ITGA4

2.99e-0318852IPR013649
DomainIntegrin_alpha2

ITGA11 ITGA4

2.99e-0318852PF08441
DomainIntegrin_alpha

ITGA11 ITGA4

2.99e-0318852IPR000413
DomainINTEGRIN_ALPHA

ITGA11 ITGA4

2.99e-0318852PS00242
DomainIG

IGSF10 FCRL2 KDR SIRPB1 SIRPA MDGA1 SIRPG

3.07e-03421857SM00409
DomainIg_sub

IGSF10 FCRL2 KDR SIRPB1 SIRPA MDGA1 SIRPG

3.07e-03421857IPR003599
DomainInt_alpha_beta-p

ITGA11 ITGA4

3.33e-0319852IPR013519
DomainInt_alpha

ITGA11 ITGA4

3.33e-0319852SM00191
DomainFG_GAP

ITGA11 ITGA4

4.46e-0322852PS51470
Domain-

CLCA4 CPNE4 ITGB2

4.67e-03748533.40.50.410
DomainActinin_actin-bd_CS

FLNA FLNB

4.87e-0323852IPR001589
DomainACTININ_2

FLNA FLNB

4.87e-0323852PS00020
DomainACTININ_1

FLNA FLNB

4.87e-0323852PS00019
DomainFG-GAP

ITGA11 ITGA4

5.29e-0324852PF01839
DomainFG-GAP

ITGA11 ITGA4

5.29e-0324852IPR013517
DomainEGF_1

BMP1 FBLN2 OIT3 C6 ITGB2

6.17e-03255855PS00022
DomainIG_LIKE

IGSF10 FCRL2 KDR SIRPB1 SIRPA MDGA1 SIRPG

7.04e-03491857PS50835
DomainEGF_2

BMP1 FBLN2 OIT3 C6 ITGB2

7.23e-03265855PS01186
DomainIg-like_dom

IGSF10 FCRL2 KDR SIRPB1 SIRPA MDGA1 SIRPG

7.99e-03503857IPR007110
PathwayBIOCARTA_BLYMPHOCYTE_PATHWAY

CR1 CR2 ITGB2

3.60e-0514673M1473
PathwayREACTOME_SIGNAL_REGULATORY_PROTEIN_FAMILY_INTERACTIONS

SIRPB1 SIRPA SIRPG

3.60e-0514673MM15011
PathwayREACTOME_SIGNAL_REGULATORY_PROTEIN_FAMILY_INTERACTIONS

SIRPB1 SIRPA SIRPG

5.50e-0516673M925
PathwayWP_CELLS_AND_MOLECULES_INVOLVED_IN_LOCAL_ACUTE_INFLAMMATORY_RESPONSE

C6 ITGA4 ITGB2

6.65e-0517673M39733
PathwayBIOCARTA_LAIR_PATHWAY

C6 ITGA4 ITGB2

6.65e-0517673M3952
PathwayREACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL

JCHAIN SIRPB1 SIRPA ITGA4 ITGB2 SIRPG

1.02e-04158676MM14812
PathwayPID_INTEGRIN_CS_PATHWAY

ITGA11 ITGA4 ITGB2

2.47e-0426673M47
PathwayREACTOME_HEMOSTASIS

FLNA SLC8A1 DOCK8 JCHAIN CAPZA2 SIRPB1 SIRPA ITGA4 ITGB2 SIRPG

3.40e-045716710MM14472
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

BMP1 ITGA11 FBLN2 CAPN7 KDR ITGA4 ITGB2

5.38e-04300677M610
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

ITGA11 KDR ITGA4 ITGB2

7.07e-0485674M16441
PathwayBIOCARTA_LYMPHOCYTE_PATHWAY

ITGA4 ITGB2

7.84e-049672MM1534
PathwayBIOCARTA_LYMPHOCYTE_PATHWAY

ITGA4 ITGB2

7.84e-049672M22008
PathwayWP_IL1_SIGNALING_PATHWAY

SIRPB1 SIRPA SIRPG

8.30e-0439673MM15996
PathwayBIOCARTA_BLYMPHOCYTE_PATHWAY

CR2 ITGB2

9.77e-0410672MM1354
PathwayWP_COMPLEMENT_SYSTEM

C6 CR1 CR2 ITGB2

1.11e-0396674M39581
PathwayREACTOME_CELL_CELL_COMMUNICATION

FLNA SIRPB1 SIRPA SIRPG

1.11e-0396674MM14592
PathwayBIOCARTA_MONOCYTE_PATHWAY

ITGA4 ITGB2

1.19e-0311672MM1436
PathwayWP_NPHP1_DELETION_SYNDROME

FLNA FLNB

1.19e-0311672M48099
PathwayBIOCARTA_MONOCYTE_PATHWAY

ITGA4 ITGB2

1.19e-0311672M4956
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

BMP1 ITGA11 FBLN2 CAPN7 ITGA4 ITGB2

1.39e-03258676MM14572
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

ITGA11 CAPN7 ITGA4 ITGB2

1.40e-03102674M39577
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

ITGA11 CAPN7 ITGA4 ITGB2

1.40e-03102674MM15830
PathwayWP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY

C6 CR1 CR2 ITGB2

1.61e-03106674M42535
Pubmed

Interaction between the integrin Mac-1 and signal regulatory protein α (SIRPα) mediates fusion in heterologous cells.

SIRPB1 SIRPA ITGB2 SIRPG

3.48e-11486430910815
Pubmed

SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.

SIRPB1 SIRPA SIRPG

1.46e-08386336202053
Pubmed

Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes.

SIRPB1 SIRPA SIRPG

1.46e-08386315034021
Pubmed

Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen.

SIRPB1 SIRPA SIRPG

1.46e-08386326222253
Pubmed

Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.

SIRPB1 SIRPA SIRPG

1.46e-08386312167615
Pubmed

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.

SIRPB1 SIRPA SIRPG

1.46e-08386331507080
Pubmed

Involvement of signal regulatory protein α, a negative regulator of Toll-like receptor signaling, in impairing the MyD88-independent pathway and intracellular killing of Burkholderia pseudomallei-infected mouse macrophages.

SIRPB1 SIRPA SIRPG

1.46e-08386322988019
Pubmed

Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain.

SIRPB1 SIRPA SIRPG

1.46e-08386322468987
Pubmed

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.

SIRPB1 SIRPA SIRPG

1.46e-08386334917090
Pubmed

Effect of Serum Deprivation Stress on Signal Induction Regulatory Protein-Alpha (SIRP-Alpha)-Mediated Erythrophagocytosis by Macrophages.

SIRPB1 SIRPA SIRPG

1.46e-08386330894504
Pubmed

Inhibitory regulation of osteoclast bone resorption by signal regulatory protein alpha.

SIRPB1 SIRPA SIRPG

1.46e-08386319667119
Pubmed

SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors.

SIRPB1 SIRPA SIRPG

1.46e-08386328669759
Pubmed

SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox).

SIRPB1 SIRPA SIRPG

1.46e-08386323022485
Pubmed

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

SIRPB1 SIRPA SIRPG

1.46e-08386329158380
Pubmed

Lack of non-hematopoietic SIRPα signaling disturbs the splenic marginal zone architecture resulting in accumulation and displacement of marginal zone B cells.

SIRPB1 SIRPA SIRPG

1.46e-08386325817792
Pubmed

Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.

SIRPB1 SIRPA SIRPG

1.46e-08386312134038
Pubmed

Central nervous system antigen P84 can serve as a substrate for neurite outgrowth.

SIRPB1 SIRPA SIRPG

1.46e-0838632303162
Pubmed

SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages.

SIRPB1 SIRPA SIRPG

1.46e-08386316141346
Pubmed

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury.

SIRPB1 SIRPA SIRPG

1.46e-08386331883525
Pubmed

Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression.

SIRPB1 SIRPA SIRPG

1.46e-08386323504854
Pubmed

SIRPα signaling regulates podocyte structure and function.

SIRPB1 SIRPA SIRPG

1.46e-08386323842779
Pubmed

Essential roles of SIRPα in homeostatic regulation of skin dendritic cells.

SIRPB1 SIRPA SIRPG

1.46e-08386320955735
Pubmed

A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9.

SIRPB1 SIRPA SIRPG

1.46e-08386317825046
Pubmed

SIRPα deficiency accelerates the pathologic process in models of Parkinson disease.

SIRPB1 SIRPA SIRPG

1.46e-08386331322787
Pubmed

Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis.

SIRPB1 SIRPA SIRPG

1.46e-08386335634325
Pubmed

The Rho kinase pathway regulates the migration of dendritic cells through SIRP-α.

SIRPB1 SIRPA SIRPG

1.46e-08386322391241
Pubmed

The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family.

SIRPB1 SIRPA SIRPG

1.46e-0838639348339
Pubmed

Targeting SIRP-α protects from type 2-driven allergic airway inflammation.

SIRPB1 SIRPA SIRPG

1.46e-08386321108471
Pubmed

Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages.

SIRPB1 SIRPA SIRPG

1.46e-08386316920950
Pubmed

Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation.

SIRPB1 SIRPA SIRPG

1.46e-08386317109464
Pubmed

Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation.

SIRPB1 SIRPA SIRPG

1.46e-08386323504624
Pubmed

Murine complement receptor gene family. II. Identification and characterization of the murine homolog (Cr2) to human CR2 and its molecular linkage to Crry.

CR1 CR1L CR2

1.46e-0838632528587
Pubmed

Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPα inhibitory signaling in mice.

SIRPB1 SIRPA SIRPG

1.46e-08386323472187
Pubmed

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103(+) CD11b(+) DCs in the intestinal lamina propria.

SIRPB1 SIRPA SIRPG

1.46e-08386325236797
Pubmed

Deficiency in SIRP-α cytoplasmic recruitment confers protection from acute kidney injury.

SIRPB1 SIRPA SIRPG

1.46e-08386331370677
Pubmed

A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.

SIRPB1 SIRPA SIRPG

1.46e-08386330770827
Pubmed

Signal regulatory protein α protects podocytes through promoting autophagic activity.

SIRPB1 SIRPA SIRPG

1.46e-08386330888336
Pubmed

Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.

SIRPB1 SIRPA SIRPG

1.46e-08386338758648
Pubmed

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.

SIRPB1 SIRPA SIRPG

1.46e-08386333795678
Pubmed

Requirement of SIRPα for protective immunity against Leishmania major.

SIRPB1 SIRPA SIRPG

1.46e-08386320854790
Pubmed

Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein.

CR1 CR1L CR2

1.46e-0838637528766
Pubmed

Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice.

SIRPB1 SIRPA SIRPG

1.46e-08386317617577
Pubmed

BIT, an immune antigen receptor-like molecule in the brain.

SIRPB1 SIRPA SIRPG

1.46e-0838639271230
Pubmed

Gene structure of mouse BIT/SHPS-1.

SIRPB1 SIRPA SIRPG

1.46e-08386310585853
Pubmed

Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.

SIRPB1 SIRPA SIRPG

1.46e-08386318635660
Pubmed

Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation.

SIRPB1 SIRPA SIRPG

1.46e-08386329914984
Pubmed

SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility.

SIRPB1 SIRPA SIRPG

1.46e-08386311118207
Pubmed

Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.

SIRPB1 SIRPA SIRPG

1.46e-08386334050181
Pubmed

Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.

SIRPB1 SIRPA SIRPG

1.46e-08386315123722
Pubmed

SIRPα+ dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes.

SIRPB1 SIRPA SIRPG

1.46e-08386331099900
Pubmed

The murine complement receptor gene family. IV. Alternative splicing of Cr2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR2 and CR1.

CR1 CR1L CR2

1.46e-0838632139460
Pubmed

Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.

SIRPB1 SIRPA SIRPG

1.46e-08386333074246
Pubmed

Resistance to collagen-induced arthritis in SHPS-1 mutant mice.

SIRPB1 SIRPA SIRPG

1.46e-08386318455510
Pubmed

Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling.

SIRPB1 SIRPA SIRPG

1.46e-08386326057870
Pubmed

Essential roles of SHPS-1 in induction of contact hypersensitivity of skin.

SIRPB1 SIRPA SIRPG

1.46e-08386318809435
Pubmed

Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function.

SIRPB1 SIRPA SIRPG

1.46e-08386319223164
Pubmed

Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages.

SIRPB1 SIRPA SIRPG

1.46e-08386318233962
Pubmed

Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury.

SIRPB1 SIRPA SIRPG

1.46e-08386323559001
Pubmed

SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress.

SIRPB1 SIRPA SIRPG

1.46e-08386322671569
Pubmed

Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.

SIRPB1 SIRPA SIRPG

1.46e-08386335511221
Pubmed

Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of alpha-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells.

SIRPB1 SIRPA SIRPG

1.46e-08386317475843
Pubmed

Focal cerebral ischemia upregulates SHP-1 in reactive astrocytes in juvenile mice.

SIRPB1 SIRPA SIRPG

1.46e-08386312742627
Pubmed

Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs.

SIRPB1 SIRPA SIRPG

1.46e-08386325818708
Pubmed

SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.

SIRPB1 SIRPA SIRPG

5.83e-08486335722884
Pubmed

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.

SIRPB1 SIRPA SIRPG

5.83e-08486322976304
Pubmed

Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.

SIRPB1 SIRPA SIRPG

5.83e-08486334097709
Pubmed

TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells.

SIRPB1 SIRPA SIRPG

5.83e-08486326907705
Pubmed

Down-regulation of platelet surface CD47 expression in Escherichia coli O157:H7 infection-induced thrombocytopenia.

SIRPB1 SIRPA SIRPG

5.83e-08486319771158
Pubmed

Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.

SIRPB1 SIRPA SIRPG

5.83e-08486333028619
Pubmed

Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPα Facilitate Apoptotic Cell Clearance by Macrophages.

SIRPB1 SIRPA SIRPG

5.83e-08486326085683
Pubmed

Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses.

SIRPB1 SIRPA SIRPG

5.83e-08486310477552
Pubmed

'Clustering' SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47.

SIRPB1 SIRPA SIRPG

5.83e-08486324143245
Pubmed

Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.

SIRPB1 SIRPA SIRPG

5.83e-08486332294445
Pubmed

Polymorphism in the innate immune receptor SIRPα controls CD47 binding and autoimmunity in the nonobese diabetic mouse.

SIRPB1 SIRPA SIRPG

5.83e-08486325305319
Pubmed

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes.

SIRPB1 SIRPA SIRPG

5.83e-08486321401967
Pubmed

Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1.

SIRPB1 SIRPA SIRPG

5.83e-08486314634079
Pubmed

CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.

SIRPB1 SIRPA SIRPG

5.83e-08486322042861
Pubmed

Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling.

SIRPB1 SIRPA SIRPG

5.83e-08486316697668
Pubmed

An essential role for the association of CD47 to SHPS-1 in skeletal remodeling.

SIRPB1 SIRPA SIRPG

5.83e-08486321638321
Pubmed

Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.

SIRPB1 SIRPA SIRPG

5.83e-08486338245585
Pubmed

Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.

SIRPB1 SIRPA SIRPG

5.83e-08486337095207
Pubmed

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.

SIRPB1 SIRPA SIRPG

5.83e-08486330308165
Pubmed

High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages.

SIRPB1 SIRPA SIRPG

5.83e-0848639712903
Pubmed

The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.

SIRPB1 SIRPA SIRPG

5.83e-08486324269920
Pubmed

Target cell CD47 regulates macrophage activation and erythrophagocytosis.

SIRPB1 SIRPA SIRPG

5.83e-08486316564725
Pubmed

Signal regulatory protein alpha1 is involved in the inhibitory effect of glucocorticoid receptor on the proliferation of murine macrophage RAW264.7 cell and mouse peritoneal macrophage.

SIRPB1 SIRPA SIRPG

5.83e-08486318728125
Pubmed

The SIRPα-CD47 immune checkpoint in NK cells.

SIRPB1 SIRPA SIRPG

5.83e-08486333416832
Pubmed

Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration.

SIRPB1 SIRPA SIRPG

5.83e-08486334197341
Pubmed

Suppressed expression of homotypic multinucleation, extracellular domains of CD172α (SIRP-α) and CD47 (IAP) receptors in TAMs upregulated by Hsp70-peptide complex in Dalton's lymphoma.

SIRPB1 SIRPA SIRPG

5.83e-08486324684700
Pubmed

SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.

SIRPB1 SIRPA SIRPG

5.83e-08486337844448
Pubmed

Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice.

SIRPB1 SIRPA SIRPG

5.83e-08486322851710
Pubmed

SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells.

SIRPB1 SIRPA SIRPG

5.83e-08486324145514
Pubmed

HSF1 promotes the viability of islet β-cells via upregulating SIRPα expression.

SIRPB1 SIRPA SIRPG

5.83e-08486332141563
Pubmed

CD47 restricts antiviral function of alveolar macrophages during influenza virus infection.

SIRPB1 SIRPA SIRPG

5.83e-08486336437873
Pubmed

Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.

CR1 CR1L CR2

5.83e-08486316127466
Pubmed

Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.

SIRPB1 SIRPA SIRPG

5.83e-08486323515050
Pubmed

Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRPα in neurons.

SIRPB1 SIRPA SIRPG

5.83e-08486334237430
Pubmed

Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.

SIRPB1 SIRPA SIRPG

5.83e-0848638810330
Pubmed

BIT (Bit) maps to mouse chromosome 2.

SIRPB1 SIRPA SIRPG

5.83e-0848639073522
Pubmed

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.

CR1 CR1L CR2

5.83e-08486330217731
InteractionABCE1 interactions

ELOC FLNA FLNB ABLIM1 IGF2R TIMM21 STRAP GLS RPS11 KDR ITGA4 RPL5

1.68e-074318212int:ABCE1
InteractionUBE2M interactions

ELOC FLNA FLNB KLHL24 IGF2R STRAP RPS11 CCT8 CPNE4 CUL7 ITGA4 TST KHDC4 RPL5

3.39e-076518214int:UBE2M
InteractionCR1 interactions

CR1 CR1L CR2

3.58e-068823int:CR1
InteractionFLNA interactions

TDRD15 FLNA FLNB ABLIM1 STRAP CAPZA2 CCT8 COBL SIRPA CUL7 ITGA4 ITGB2

1.17e-056488212int:FLNA
InteractionASB2 interactions

ELOC FLNA FLNB CUL7

2.53e-0542824int:ASB2
InteractionFLNB interactions

FLNA FLNB STRAP CAPZA2 CCT8 CUL7 ITGA4 ITGB2

3.31e-05304828int:FLNB
InteractionAFF3 interactions

AFF3 MLLT1 MLLT3

3.50e-0516823int:AFF3
InteractionCHMP4B interactions

IGSF10 ELOC FLNA FLNB ABLIM1 IGF2R CAPN7 RPS11 CAPZA2 COBL ITGA4 RPL5

3.63e-057278212int:CHMP4B
InteractionATG9B interactions

FLNA FLNB CAPZA2

8.19e-0521823int:ATG9B
InteractionSIRPG interactions

SIRPA SIRPG

9.76e-054822int:SIRPG
InteractionCDK9 interactions

FLNA FLNB ABLIM1 AFF3 RPS11 CAPZA2 CCT8 MLLT1 MLLT3 ACTL6A OVOL2

1.01e-046858211int:CDK9
InteractionCAPZA1 interactions

ELOC FLNA STRAP CAPZA2 CCT8 PRMT3 CUL7 ITGA4

1.21e-04366828int:CAPZA1
Cytoband13q13

NBEA DCLK1

3.46e-05586213q13
CytobandEnsembl 112 genes in cytogenetic band chr13q13

FREM2 NBEA DCLK1

5.05e-0482863chr13q13
Cytoband20p13

SIRPB1 SIRPA SIRPG

9.53e-0410286320p13
Cytoband6q22.1

SLC22A16 GPRC6A

1.36e-03298626q22.1
CytobandEnsembl 112 genes in cytogenetic band chr20p13

SIRPB1 SIRPA SIRPG

1.63e-03123863chr20p13
Cytoband3q22.1

NPHP3 CPNE4

2.84e-03428623q22.1
Cytoband1q32

CR1 CR2

3.85e-03498621q32
Cytoband5q32

ABLIM3 SPINK5

4.66e-03548625q32
GeneFamilyADAM metallopeptidase domain containing|CD molecules

FCRL2 IGF2R KDR SIRPB1 SIRPA ITGA4 LY75 CR1 CR2 ITGB2 SIRPG

1.43e-073946511471
GeneFamilyComplement system|Sushi domain containing

C6 CR1 CR1L CR2 ITGB2

1.78e-0736655492
GeneFamilyCD molecules|V-set domain containing|C1-set domain containing|Signal regulatory proteins

SIRPB1 SIRPA SIRPG

4.41e-075653747
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

PAPPA2 C6 CR1 CR1L CR2

1.86e-06576551179
GeneFamilyAF4/FMR2 family|Super elongation complex

AFF3 MLLT1 MLLT3

3.67e-0696531280
GeneFamilySuper elongation complex|YEATS domain containing

MLLT1 MLLT3

7.60e-0546521283
GeneFamilyC1-set domain containing

SIRPB1 SIRPA SIRPG

4.61e-0442653591
GeneFamilyCD molecules|Integrin alpha subunits

ITGA11 ITGA4

1.88e-03186521160
GeneFamilyAdenosine receptors|V-set domain containing

KDR SIRPB1 SIRPA SIRPG

2.81e-03163654590
CoexpressionRAMALHO_STEMNESS_DN

BMP1 ABLIM1 SIRPB1 SIRPA ITGB2 SIRPG

2.22e-0778866MM1015
CoexpressionDUTERTRE_ESTRADIOL_RESPONSE_24HR_DN

CPEB2 KLHL24 NPHP3 EFNB2 BAZ2B CPEB4 ENTPD3 NBEA PARP9 ABLIM3 DCLK1

7.95e-075048611M2157
CoexpressionBAKKER_FOXO3_TARGETS_UP

CPEB4 SIRPB1 SIRPA CR2 SIRPG

1.13e-0656865MM903
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBGABA

CPEB2 SLC8A1 EML5 GLS CPEB4 NBEA SIRPA REV3L BRSK1 MDGA1 ABLIM3 DCLK1

3.15e-067038612M39070
CoexpressionSTEARMAN_TUMOR_FIELD_EFFECT_UP

SIRPB1 SIRPA LY75 SIRPG

1.21e-0543864MM1035
CoexpressionGSE4984_UNTREATED_VS_GALECTIN1_TREATED_DC_DN

FCRL2 FLNB ABLIM1 JCHAIN AFF3 CR2

3.90e-05190866M6496
CoexpressionGSE42724_NAIVE_VS_MEMORY_BCELL_DN

IGF2R GLS CPEB4 RPS11 PARP9 ITGA4

5.18e-05200866M9793
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_VASCULAR_SMC_1_CELL

ITGA11 MLLT3 NBEA ITGA4 ADGRL3

5.60e-05124865M45686
CoexpressionSTEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP

ELOC KDR SIRPB1 SIRPA SIRPG

8.10e-05134865MM748
ToppCellfacs-Lung-EPCAM-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 GK DOCK8 SIRPA ITGA4 ITGB2

2.91e-08162867484ea4ac40de672dcbd2583a52cb7f385c918814
ToppCellfacs-Lung-EPCAM-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 GK DOCK8 SIRPA ITGA4 ITGB2

2.91e-08162867bba144ac5332bab9eba2ccf599703c781a7f88f1
ToppCellControl-B_cells-B_cells|Control / group, cell type (main and fine annotations)

FCRL2 DOCK8 AFF3 ITGA4 CR1 ZNF107 CR2

5.15e-08176867d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCellcontrol-Lymphoid-B_cell|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FCRL2 DOCK8 JCHAIN AFF3 CR1 CR2 ITGB2

6.24e-08181867e414303bb90e5fe7b667c2acf9a50f8694b90e54
ToppCellNS-control-d_0-4-Lymphoid-B_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FCRL2 DOCK8 JCHAIN AFF3 CR1 CR2 ITGB2

6.48e-081828674b9b55154a79992112c1c467e8752c3cdbb541d9
ToppCellFetal_29-31_weeks-Immune-B_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FCRL2 DOCK8 JCHAIN AFF3 ITGA4 ZNF107 CR2

6.98e-08184867f4c9272d5cc4a70df051413b5c60ca6d1d80eb84
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FCRL2 DOCK8 JCHAIN AFF3 ITGA4 CR1 CR2

6.98e-08184867f81209e6bc01a0140f4487aa8b22eb02fbf0c39c
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-B_lymphocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FCRL2 JCHAIN AFF3 RPS11 CR1 CR2 RPL5

1.00e-07194867b700381f8337b4c6aa50d09ab5bfcd59f2fb2cf3
ToppCellsevere-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PLBD1 SLC8A1 GK BAZ2B CPEB4 SIRPA CR1

1.15e-07198867d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCellfacs-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA PLBD1 DOCK8 SIRPA ITGA4 ITGB2

6.36e-07158866121d63b8e2e37107467b170e5b2c798a7dbf6325
ToppCellfacs-Lung-18m-Hematologic-myeloid-non-classical_monocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA PLBD1 DOCK8 SIRPA ITGA4 ITGB2

6.84e-07160866bc4a93dc5f37829799c37877e751ff3bc122e4ab
ToppCelldroplet-Kidney-nan-24m-Myeloid-CD45____macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 SIRPA C6 ITGA4 ITGB2

7.91e-07164866d57faa4fce1f1e9a92aaf5cb920af99323252e4b
ToppCellfacs-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA PLBD1 DOCK8 SIRPA ITGA4 ITGB2

7.91e-0716486611dfd84f5fb90de330858e1e852848832734e004
ToppCelldroplet-Kidney-nan-24m-Myeloid-macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 SIRPA C6 ITGA4 ITGB2

7.91e-07164866d0b6c29e61d15f4dbe4c1f6e5ed3e10f41f820ab
ToppCelldroplet-Kidney-nan-24m-Myeloid|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 SIRPA C6 ITGA4 ITGB2

7.91e-07164866718cc64b7ef7d03d095be4b2b54c449154da568c
ToppCellCOVID-19-kidney-Bcells|COVID-19 / Disease (COVID-19 only), tissue and cell type

FCRL2 TDRD15 AFF3 ITGA4 CR1 CR2

1.01e-061718668e8fb79968b1a5c34d1d9cad7f9155fabfdb7cc7
ToppCellLPS-antiTNF-Lymphocytic_B|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 ABLIM1 JCHAIN AFF3 CR1 CR2

1.12e-06174866cc493654ea3517bc6a145c7f787f304929636f86
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 ABLIM1 JCHAIN AFF3 CR1 CR2

1.12e-061748669eb3504f9340517ef5d056503044fbdb9ffeb714
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 ABLIM1 JCHAIN AFF3 CR1 CR2

1.12e-06174866b4c2d1c029fcd0d4926aa79a5b789c713919dcf3
ToppCellControl|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AFF3 MLLT3 KDR C6 ITGA4 ADGRL3

1.23e-06177866b8ff6940e31b749776e81ae4f5bbd577dba9749c
ToppCellLPS_only-Lymphocytic_B-B_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 ABLIM1 JCHAIN AFF3 CR1 CR2

1.23e-06177866c82332c5f656aa26513e4f7525d5d4d733019725
ToppCellLPS_only-Lymphocytic_B|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 ABLIM1 JCHAIN AFF3 CR1 CR2

1.23e-061778665ed65e08d773d157840317c72e0d43c261d438d4
ToppCellLPS_only-Lymphocytic_B-B_cells-B-cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 ABLIM1 JCHAIN AFF3 CR1 CR2

1.23e-061778668a955a7ab84c434f9ad4b467246b8be3cb479406
ToppCellnormal_Lung-B_lymphocytes-Follicular_B_cells|normal_Lung / Location, Cell class and cell subclass

FCRL2 JCHAIN AFF3 RPS11 CR2 RPL5

1.45e-0618286613c39228f76495deca6b948483bbde426b3e8c5b
ToppCellChildren_(3_yrs)-Immune-B_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

FCRL2 JCHAIN AFF3 ITGA4 CR1 CR2

1.65e-06186866aa576748921a318798b911a611f05319b95e8d5e
ToppCellImmune-B_cell|World / Lineage, Cell type, age group and donor

FCRL2 JCHAIN AFF3 ITGA4 ZNF107 CR2

1.70e-06187866795690c6306c366e733279491138d0cd9b469b21
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF10 BMP1 ITGA11 FBLN2 CNGA3 DCLK1

1.81e-06189866f0a2d4ef9896d764971ebbc6952510c128bb76e8
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF10 BMP1 ITGA11 FBLN2 CNGA3 DCLK1

1.81e-06189866378f26f751ab4b470948c35dd8347de72dd12ff7
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

IGSF10 SLC8A1 ENTPD3 CPNE4 ABLIM3 ADGRL3

1.86e-061908666e92c78799f34b31d098854503c796edb0dc7f80
ToppCellILEUM-inflamed-(2)_B_cell|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FCRL2 AFF3 RPS11 CR1 CR2 RPL5

1.92e-061918660aa913678456b7d525bd177588f2463f6ed76cd7
ToppCellILEUM-non-inflamed-(2)_B_cell|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FCRL2 AFF3 RPS11 CR1 CR2 RPL5

1.92e-06191866d4496994dd973eb6d0d8b9101a390af237e12fb2
ToppCellNasal_Brush-Immune-Neutrophils|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

SLC8A1 DOCK8 SIRPB1 SIRPA CPNE4 ITGB2

1.98e-0619286620a7f7beb01df1c4f915ec2f9b5a9dbcab157187
ToppCellB_cells-Memory_B_cells|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

FCRL2 DOCK8 AFF3 RPS11 CR1 CR2

1.98e-06192866eef591095921ede098f41a2b81897b18915bb753
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABLIM1 KLHL24 JCHAIN AFF3 RPS11 RPL5

1.98e-06192866aee6522d25e012231cdb905ce047295cb64d6e82
ToppCell(4)_B_cells|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

FCRL2 AFF3 RPS11 CR1 CR2 RPL5

1.98e-0619286660f348e38d09312136b077f6a298258475cedd0a
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 FLNB EML5 ENTPD3 SIRPA OVOL2

2.04e-06193866471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelltumor_Lung-B_lymphocytes-Follicular_B_cells|tumor_Lung / Location, Cell class and cell subclass

FCRL2 JCHAIN AFF3 RPS11 CR2 RPL5

2.04e-06193866d0cb4bfc11491c903cb4cc0f823dd1ee239cf5c4
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 FLNB EML5 ENTPD3 SIRPA OVOL2

2.04e-06193866fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellmild-Lymphocytic-B_cells_1|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FCRL2 JCHAIN AFF3 RPS11 CR2 RPL5

2.10e-06194866fad1986cba9cd23ac68e639d7335fbcd6ae2a4e7
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-B_lymphocytic-memory_B_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FCRL2 AFF3 RPS11 CR1 CR2 RPL5

2.10e-0619486684aa5ca0356a06fce8799eb1bfa1c362bab34032
ToppCelldroplet-Trachea-nan-3m-Mesenchymal-mesenchymal_progenitor_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 BMP1 ABLIM1 FBLN2 CPNE4 DCLK1

2.10e-061948663d25d6ebec8d1b6001f602257cd15b3ba04cf0c1
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FCRL2 TDRD15 DOCK8 AFF3 CR1 CR2

2.16e-061958663311a1bf4ed94820b45047d44fc14b14ac72e6fb
ToppCellFibroblasts-CD34+_Fibroblasts|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

ABLIM1 ITGA11 FBLN2 RPS11 C6 DCLK1

2.16e-06195866c6b5249ac8714b1b701cde31d00ab53f28355c36
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA ITGA11 SLC8A1 AFF3 DCLK1 ADGRL3

2.23e-061968661522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC8A1 DOCK8 AFF3 ITGA4 CR1 ITGB2

2.23e-061968664370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA ITGA11 SLC8A1 AFF3 DCLK1 ADGRL3

2.23e-061968661c8294014713684b50885e638668f2ce75f357f0
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLBD1 SLC8A1 GK DOCK8 SIRPB1 SIRPA

2.23e-061968665fe6534af65d43eeacd4b031310242b4f706008b
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FCRL2 AFF3 ITGA4 CR1 ZNF107 CR2

2.29e-06197866fd65020089baca78334cecddc96b7a65028c2b7c
ToppCellcontrol-Lymphocytic-B_cells_1|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FCRL2 JCHAIN AFF3 RPS11 CR2 RPL5

2.29e-0619786669dcda785c94f5f15300c73478fa825751c702d5
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-B_lymphocytic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FCRL2 JCHAIN AFF3 RPS11 CR2 RPL5

2.29e-06197866e9327b133dab5f6a187cd8713f07205c948ec600
ToppCellFetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLC8A1 GK DOCK8 SIRPA CR1 ITGB2

2.36e-06198866ab70bf89690410221ec7aa3149bb50ac34433f99
ToppCellImmune|World / Lineage, Cell type, age group and donor

SLC8A1 GK DOCK8 SIRPA ITGA4 ITGB2

2.36e-0619886665681b54d13c6997bd90a1c2a12314a80e964fe3
ToppCell(0)_Myeloid-(01)_Dendritic_cell-(010)_cDC|(01)_Dendritic_cell / immune cells in Peripheral Blood (logTPM normalization)

FLNA PLBD1 SLC8A1 CAPZA2 SIRPA ITGB2

2.36e-061988664abc274edac40f8836255fac2371ffd98a32cccd
ToppCellTracheal-NucSeq-Immune_Lymphocytic-B-B_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FCRL2 DOCK8 AFF3 ITGA4 CR1 CR2

2.36e-06198866824461cf44098440ba8bc0df96735423ac65bda1
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CCL|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SLC8A1 GK SLC22A16 CR1 ITGB2 ZNF304

2.43e-0619986652c06fcc112da21b1d914a896c04bde06fc756fe
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_granulocytic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLC8A1 GK IGF2R SIRPB1 SIRPA CR1

2.43e-06199866119807ea333d1dc7743c6b9f03a2c63e09e19541
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLC8A1 GK IGF2R SIRPB1 SIRPA CR1

2.43e-06199866691e04871cd6cac0ea5fca1b7fd6421df9315db6
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PLBD1 ZNF630 IGF2R SIRPB1 CR1 ITGB2

2.43e-061998664e0b73d88b1345ec63a9e5629762341e75beb47f
ToppCellFetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLC8A1 GK DOCK8 SIRPA CR1 ITGB2

2.43e-0619986622001aa733273e784051b7f750e07d99aaf7a225
ToppCellCOVID-19_Severe-Classical_Monocyte|COVID-19_Severe / Disease condition and Cell class

FLNA PLBD1 RPS11 SIRPA CR1 ITGB2

2.43e-06199866ea1e2ccde3930fab6d04a9bf130837455c742474
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-B_lymphocytic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FCRL2 JCHAIN AFF3 RPS11 CR1 CR2

2.43e-061998661aa963ed5205d6d52262b1597a5d08707a95c3ca
ToppCell10x5'-bone_marrow-Myeloid_Monocytic-Classical_monocytes|bone_marrow / Manually curated celltypes from each tissue

PLBD1 SLC8A1 GK SIRPB1 SIRPA CR1

2.43e-061998662c747e9265594e12d46bd8c8de75c45e83144155
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLNB SLC8A1 CLCA4 FBLN2 EFNB2 SLC22A16

2.50e-06200866ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCell(40)_Monocyte|World / shred on Cell_type and subtype

PLBD1 SLC8A1 GK SIRPB1 SIRPA SIRPG

2.97e-06206866d78a70f951265ef6df8f64404107be4f53e75d28
ToppCellControl-PLT_4|World / Disease Group and Platelet Clusters

KLHL24 LEMD3 CR1L KHDC4 ZNF304

1.23e-05154865a2a03c5e6759c45aeeedf1e68ecb5a0112ef9a20
ToppCellfacs-Lung-Endomucin-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA GK SIRPA ITGA4 ITGB2

1.35e-051578650ad242320ada7bcb9e29548d3050bf4fd3a07115
ToppCellfacs-Lung-Endomucin-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA GK SIRPA ITGA4 ITGB2

1.35e-05157865fe4c9556806203e57522d1986754ebe5a20aa2de
ToppCellBronchial_Brush-Epithelial-Goblet_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CLCA4 FBLN2 SIRPA ABLIM3 ITGB2

1.43e-0515986595834b767cfb4fb8c5aeea89c10f3e14a1fd15c1
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA JCHAIN ITGA4 LY75 ADGRL3

1.47e-05160865e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLBD1 DOCK8 SIRPA ITGA4 ITGB2

1.47e-051608652020b6defbaf5b5db12af37f0103ac028a8ca76e
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLBD1 DOCK8 SIRPA ITGA4 ITGB2

1.47e-05160865af7cf0dc5fe7c02f7d6c436f6dde766c79ff0eae
ToppCellfacs-Lung-nan-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 SIRPA ITGA4 ITGB2

1.57e-051628653fd6aaf0fbaffc7ab38aa25e46c37ef511e1e704
ToppCellfacs-Lung-nan-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 SIRPA ITGA4 ITGB2

1.57e-051628658134f73eb76693f4f1845f643042fdc1e81c274c
ToppCellfacs-Lung-3m-Hematologic-myeloid-non-classical_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA PLBD1 SIRPA ITGA4 ITGB2

1.61e-05163865bbbc3f0ce2616d07136f69ce682ba1d3790711d9
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3|TCGA-Uterus / Sample_Type by Project: Shred V9

CPEB2 EML5 DOCK8 ENTPD3 OVOL2

1.61e-05163865d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCellsevere-Lymphocytic-B_cells_2|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FCRL2 ABLIM1 AFF3 CR2 RPL5

1.66e-05164865a1031e9f945a15186ee14c12be47aa11c3c6583b
ToppCellfacs-Lung-nan-3m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 SIRPA ITGA4 ITGB2

1.71e-05165865720649f330382ea2a68c64a5344160a048afb8f1
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNA PLBD1 SIRPA ITGA4 ITGB2

1.71e-051658659a6abd0e6b11860231ce5e845c87b8d66f3ef697
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 IGF2R AFF3 ITGA4

1.71e-05165865ab6ed7e30096c418e7be2d5eec33feeddd1387d9
ToppCellControl-Lymphocytic_B-B_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 DOCK8 JCHAIN CR1 CR2

1.81e-05167865a15a70d3837b31cc83a2a9e3f1bbfd77a95f2312
ToppCellControl-Lymphocytic_B|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 DOCK8 JCHAIN CR1 CR2

1.81e-05167865956da82394fd6a9f45fc2031796f12cc889542cd
ToppCellControl-Lymphocytic_B-B_cells-B-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 DOCK8 JCHAIN CR1 CR2

1.81e-0516786569ed8a4a507190a1a66c4baf1f3e9be21ada39d8
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 JCHAIN AFF3 CR1 CR2

1.87e-05168865eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 JCHAIN AFF3 CR1 CR2

1.87e-05168865063d0368d656962b335154c230bdcd9236e7c9ad
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 JCHAIN AFF3 CR1 CR2

1.87e-05168865a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA GK SIRPA ITGA4 ITGB2

1.87e-05168865c0aef5947b1d7e2c81a7481c509feda1687fcd7f
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA GK SIRPA ITGA4 ITGB2

1.87e-05168865c861f80aa12caf54a94d93e38539ff41dc5227a6
ToppCelldroplet-Lung-nan-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 GK ITGA4 ITGB2

1.92e-05169865ba023ee7bb165c2bfbefc2d969ff32ca1eeed33b
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 PLBD1 SIRPA C6 ITGB2

1.92e-051698650f5e737b265ba333275a0cd289dab029a1542075
ToppCelldroplet-Lung-nan-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA PLBD1 GK ITGA4 ITGB2

1.92e-05169865c96e0f3241d13926dbee9f91c0c8c5bfa7479a0d
ToppCelldroplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA PLBD1 SIRPA ITGA4 ITGB2

1.92e-05169865b059304543876f514d5c7214f1f0a2da00f10a67
ToppCelldroplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA PLBD1 SIRPA ITGA4 ITGB2

1.92e-05169865945f737984c4de70a4e9c214053b005358053dd5
ToppCellfacs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNA PLBD1 SIRPA ITGA4 ITGB2

1.92e-05169865907e4c7d0df6dd46664d69834251aebca8e1dd1e
ToppCelldroplet-Heart-4Chambers-21m-Hematologic-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLBD1 DOCK8 SIRPA ITGA4 ITGB2

1.97e-051708658ea5ab8c890eb91c5b0aae3996e1d1c61c97f0c7
ToppCellLPS-IL1RA-Lymphocytic_B-B_cells-B-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 JCHAIN AFF3 CR1 CR2

1.97e-0517086592e0873f618b2fa60c4d555b10f234d5cbcf3325
ToppCellLPS-IL1RA-Lymphocytic_B-B_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 JCHAIN AFF3 CR1 CR2

1.97e-05170865c181991f933b779f99afc3782f292306f209e2ac
ToppCellLPS-IL1RA-Lymphocytic_B|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FCRL2 JCHAIN AFF3 CR1 CR2

1.97e-0517086556284fbfd1e53f67c8c0b7fba64505a4002adba2
ToppCellLAM-Lymphoid-B-cell-1|LAM / Condition, Lineage and Cell class

FCRL2 JCHAIN RPS11 CR2 RPL5

1.97e-051708652b822a95a8d7ee193d40231418d6bd4cf9662842
ToppCellfacs-Lung-18m-Hematologic-myeloid|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLBD1 DOCK8 SIRPA ITGA4 ITGB2

2.03e-051718654ad28ecfde3d529a09b80be908c446bd5274518e
ToppCellAdult-Immune-B_cell-D175|Adult / Lineage, Cell type, age group and donor

FCRL2 ZNF560 JCHAIN BRSK1 CR2

2.03e-05171865355a246f3395900342d400f6f7c6640cba0d4d5d
Diseasesignal-regulatory protein beta-1 measurement

SIRPB1 SIRPA SIRPG

1.78e-069833EFO_0802069
Diseasethreonine measurement

ELOC GLS CPEB4 C6

3.58e-0637834EFO_0009775
Diseaselevel of tyrosine-protein phosphatase non-receptor type substrate 1 in blood serum

SIRPB1 SIRPA

7.82e-062832OBA_2040362
Diseaseimmature platelet fraction

DOCK8 CAPZA2 SIRPB1 SIRPA SIRPG

1.80e-05114835EFO_0009187
Diseaseimmature platelet measurement

DOCK8 CAPZA2 SIRPB1 SIRPA SIRPG

2.21e-05119835EFO_0803541
Diseasemyofibrillar myopathy 5 (implicated_via_orthology)

FLNA FLNB

2.34e-053832DOID:0080096 (implicated_via_orthology)
Diseasedistal muscular dystrophy 4 (implicated_via_orthology)

FLNA FLNB

2.34e-053832DOID:0111190 (implicated_via_orthology)
Diseaseblood sedimentation

CR1 CR1L

1.63e-047832EFO_0004304
Diseaseimmature platelet count

CAPZA2 SIRPB1 SIRPA SIRPG

2.32e-04106834EFO_0803544
Diseaseplatelet measurement

DOCK8 CAPZA2 SIRPB1 SIRPA LY75 SIRPG

2.67e-04315836EFO_0005036
Diseasenephritis (implicated_via_orthology)

ITGA4 ITGB2

3.47e-0410832DOID:10952 (implicated_via_orthology)
Diseasepneumonia (implicated_via_orthology)

ITGA4 ITGB2

3.47e-0410832DOID:552 (implicated_via_orthology)
Diseaseguanosine diphosphate measurement

BAZ2B NBEA

4.23e-0411832EFO_0010494
Diseaseurate measurement, spine bone mineral density

PAPPA2 SLC8A1 CPNE4

5.92e-0458833EFO_0004531, EFO_0007701
Diseasecolorectal mucinous adenocarcinoma

SLC22A16 IER5L

9.14e-0416832EFO_0009361
DiseaseSchwartz-Jampel Syndrome, Type 1

FLNA KDR

9.14e-0416832C4551479
DiseaseSpondyloepiphyseal Dysplasia

FLNA KDR

9.14e-0416832C0038015
DiseaseSchwartz-Jampel Syndrome

FLNA KDR

9.14e-0416832C0036391
DiseaseMelnick-Needles Syndrome

FLNA KDR

9.14e-0416832C0025237
DiseaseSpondyloepiphyseal Dysplasia Tarda, X-Linked

FLNA KDR

9.14e-0416832C3541456
DiseaseVan Buchem disease

FLNA KDR

1.03e-0317832C0432272
Diseaseosteochondrodysplasia (is_implicated_in)

FLNA FLNB

1.30e-0319832DOID:2256 (is_implicated_in)
DiseaseDyschondroplasias

FLNA KDR

1.30e-0319832C0013366
DiseaseOsteochondrodysplasias

FLNA KDR

1.30e-0319832C0029422
DiseaseDisproportionate short stature

FLNA FLNB CUL7

1.35e-0377833C0878659
DiseaseMultiple Epiphyseal Dysplasia

FLNA KDR

1.44e-0320832C0026760
Diseasecolorectal carcinoma (is_implicated_in)

EFNB2 STRAP

1.74e-0322832DOID:0080199 (is_implicated_in)
Diseaseglioblastoma (is_implicated_in)

KDR RPL5

2.07e-0324832DOID:3068 (is_implicated_in)
Diseasemean platelet volume

DOCK8 GLS CPEB4 AFF3 CAPZA2 SIRPB1 SIRPA LY75 SIRPG

2.27e-031020839EFO_0004584
Diseasemitochondrial DNA measurement

SIRPB1 SIRPA LY75 OVOL2 SIRPG

2.36e-03328835EFO_0006312
DiseaseHeart valve disease

C6 ITGB2

2.43e-0326832C0018824

Protein segments in the cluster

PeptideGeneStartEntry
YYNPVKEDVQDCGKV

AFF3

496

P51826
TGEYISKDGVPYCES

ABLIM3

186

O94929
TGEYISKDGAPYCEK

ABLIM1

261

O14639
SKDGAPYCEKDYQGL

ABLIM1

266

O14639
LQGEVAYYAPCGKKL

BAZ2B

766

Q9UIF8
CKDPPYKVEESGYAG

MLLT3

66

P42568
YTVRAGYAGEDCPKV

ACTL6A

21

O96019
PPAKCGDAEDVYYKS

ADGRL3

1381

Q9HAR2
GFGCSKYYEKIPDQM

BRWD3

541

Q6RI45
PTNDGTCIEIGYVKY

BTBD11

956

A6QL63
AVEGKIYLTVYCPKD

ADAD1

361

Q96M93
IGRYCGYEKPDDIKS

BMP1

506

P13497
ETCSFDGVYQPKIKG

ENTPD3

351

O75355
TPCDPKYGAGIYFTK

PARP9

726

Q8IXQ6
IGYYLKEKKCFPEGT

GLS

391

O94925
EGCVYVKCLSPEYAG

LEMD3

831

Q9Y2U8
YYCKAENGVGVPAIK

MDGA1

106

Q8NFP4
CPDYYEAVCGTDGKT

SPINK5

111

Q9NQ38
KVFLCTGADGYVPKY

FREM2

2916

Q5SZK8
YGCTVFPDGSKEEGK

JPH1

316

Q9HDC5
GESYVCGSIEPFKKL

DCLK1

126

O15075
ICPKVDSKTVGQYEY

EFNB2

61

P52799
YKALTCEPGYALKDG

FBLN2

746

P98095
DGTYACSYTPVKAIK

FLNB

701

O75369
NTTVEVKACPGGYYV

OIT3

116

Q8WWZ8
NCHVYKKYGPEALAG

CUL7

561

Q14999
GETCYKIYEDEVPFG

LY75

511

O60449
GYQKTGDVYKCPVIH

ITGA11

66

Q9UKX5
VCVYTPVGKAEQGKF

NPEPPSL1

266

A6NEC2
DKLYVCEDCGYTGPT

OVOL2

211

Q9BRP0
PGGCYDTKVADIYLA

PLBD1

486

Q6P4A8
CGYLKIKGLTEEYPT

GID4

156

Q8IVV7
PGVKLGYEIYDTCTE

GPRC6A

91

Q5T6X5
TSDVPGKLIYGQYCE

ITGB2

521

P05107
CKPGYYVAESAEGKV

PAPPA2

1556

Q9BXP8
GIYKCTAKNPLGSDY

IGSF10

2601

Q6WRI0
VAGGLTKAIYCYDPV

KLHL24

506

Q6TFL4
KYSCNPGYVLVGEES

CR2

436

P20023
CAEPYTVIKESDGGK

DOCK8

361

Q8NF50
GVCYAGIDTDPELKY

CPEB2

466

Q7Z5Q1
DGEPEYNPCGKYMVK

CAPN7

321

Q9Y6W3
GTYGENCEKQSPDYK

C6

546

P13671
GDIPYGKEISYACDT

CR1

1791

P17927
YLAKGGSVYPDICTI

PRMT3

351

O60678
KDGSCSVEYIPYEAG

FLNA

1406

P21333
LGDIPYGKEVSYTCD

CR1L

491

Q2VPA4
VVDYYNGKGIKPKCS

CPNE4

531

Q96A23
YAEKGYAGKAPVLAA

COBL

891

O75128
IEKLAKEVGTSYGCY

GK

351

P32189
KTYGGCEGPDAMYVK

ELOC

6

Q15369
YACPEVIKGEKYDGR

BRSK1

196

Q8TDC3
CFSYKGKEVPGYIVL

ITGA4

501

P13612
FNVKEKVEGPGCSYL

KHDC4

246

Q7Z7F0
IYEKKYGQVPMCDAG

CARTPT

71

Q16568
GVCYAGIDTDPELKY

CPEB4

606

Q17RY0
CYTAVVPLVYGGETK

JCHAIN

131

P01591
SGCYKRHVYEVPSGK

EML5

1841

Q05BV3
CKEPPYKVEESGYAG

MLLT1

66

Q03111
EIPAVKESDAGKYYC

FCRL2

261

Q96LA5
SEPGSCYEELLKYVG

CACNA1H

451

O95180
VPYGVGKAACDKLAA

DHRS1

161

Q96LJ7
SAAGCKRKYYPGQEE

IER5L

296

Q5T953
IEGTYIDKKCPFTGN

RPS11

51

P62280
KVVVTYSKGYPCGGN

IGF2R

2071

P11717
TVLEVKCSCYYGPGD

TDRD15

756

B5MCY1
GDPAEGVYKTYICVE

NPHP3

431

Q7Z494
SLGYEYTGSKKEFPC

SLC22A16

111

Q86VW1
YTGSKKEFPCVDGYI

SLC22A16

116

Q86VW1
DKPYLYCFRTSKGVG

NBEA

276

Q8NFP9
AGTYYCVKFRKGSPD

SIRPA

116

P78324
CAAYAHELPKYGVKV

RPL5

76

P46777
PADVGTYYCVKFRKG

SIRPG

111

Q9P1W8
TPYGYFLISACKDGK

STRAP

26

Q9Y3F4
YPNGVCTVYGKKIDG

CAPZA2

136

P47755
PYTKQFTECGEKGEY

CLCA4

116

Q14CN2
TVFSPGDYICKKGDI

CNGA3

501

Q16281
GTYYCVKFRKGSPDD

SIRPB1

116

O00241
TGEKPYKYEECGKVF

ZNF107

211

Q9UII5
KEYRGSFSYKPGACV

REV3L

2911

O60673
YCDAVKKTSPYDSGP

FAM20B

256

O75063
RIHTGEKPYECTKYG

ZNF630

311

Q2M218
TCVKFYIEGSEPGKQ

TIMM21

191

Q9BVV7
VIHTGEKPYKYEECG

ZNF492

441

Q9P255
PKVIGNDTGAYKCFY

KDR

91

P35968
GEKPYVCSECGKAYS

ZNF304

611

Q9HCX3
IIHRGEKPYKYQECG

ZNF355P

176

Q9NSJ1
AYLCGKPDVAVYDGS

TST

261

Q16762
YGETCPGLEQYAIKK

CCT8

426

P50990
KPYEYKDCGKAFVVS

ZNF560

626

Q96MR9
TGECTGSYYCKKGVI

SLC8A1

46

P32418