Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside diphosphate phosphatase activity	GBP1 GBP3 ALPL	1.19e-04	20	97	3	GO:0017110
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF7 KDM4C NR4A2 PRAMEF8 BRD8 MED12	3.04e-04	187	97	6	GO:0016922
GeneOntologyMolecularFunction	neuregulin binding	ERBB3 ITGAV	3.46e-04	6	97	2	GO:0038132
GeneOntologyMolecularFunction	GTPase activator activity	DOCK4 ARHGAP24 RAP1GAP2 ARHGAP4 TBCK ARHGAP27 SIPA1L2	4.24e-04	279	97	7	GO:0005096
GeneOntologyMolecularFunction	Fc-gamma receptor I complex binding	FLNA FGR	4.83e-04	7	97	2	GO:0034988
GeneOntologyMolecularFunction	phospholipase D activity	PLD3 PLD2	6.42e-04	8	97	2	GO:0004630
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK4 ARHGAP24 RAP1GAP2 GBP1 GBP3 ARHGAP4 TBCK ARHGAP27 SIPA1L2	8.07e-04	507	97	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK4 ARHGAP24 RAP1GAP2 GBP1 GBP3 ARHGAP4 TBCK ARHGAP27 SIPA1L2	8.07e-04	507	97	9	GO:0030695
GeneOntologyBiologicalProcess	epiboly involved in wound healing	FLNA ARHGAP24 ITGAV MTOR	6.71e-05	46	98	4	GO:0090505
GeneOntologyBiologicalProcess	wound healing, spreading of cells	FLNA ARHGAP24 ITGAV MTOR	6.71e-05	46	98	4	GO:0044319
GeneOntologyBiologicalProcess	blood coagulation, fibrin clot formation	FLNA F8 FGA	6.74e-05	17	98	3	GO:0072378
GeneOntologyBiologicalProcess	epiboly	FLNA ARHGAP24 ITGAV MTOR	7.31e-05	47	98	4	GO:0090504
GeneOntologyCellularComponent	host cell part	GBP6 GBP1 GBP3	1.98e-06	6	98	3	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP6 GBP1 GBP3	1.98e-06	6	98	3	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP6 GBP1 GBP3	1.98e-06	6	98	3	GO:0033655
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP6 GBP1 GBP3	1.98e-06	6	98	3	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP6 GBP1 GBP3	1.98e-06	6	98	3	GO:0020005
GeneOntologyCellularComponent	host intracellular region	GBP6 GBP1 GBP3	1.98e-06	6	98	3	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP6 GBP1 GBP3	1.98e-06	6	98	3	GO:0030430
GeneOntologyCellularComponent	host cellular component	GBP6 GBP1 GBP3	4.36e-05	15	98	3	GO:0018995
GeneOntologyCellularComponent	cell projection membrane	GABRG3 TSPEAR CUBN ITGAV PTPRJ SYNE2 KIRREL1 PLD2 FGR	1.93e-04	431	98	9	GO:0031253
GeneOntologyCellularComponent	symbiont cell surface	GBP1 GBP3	5.98e-04	8	98	2	GO:0106139
GeneOntologyCellularComponent	other organism part	GBP1 GBP3	7.67e-04	9	98	2	GO:0044217
GeneOntologyCellularComponent	COPI vesicle coat	COPG1 COPG2	1.64e-03	13	98	2	GO:0030126
GeneOntologyCellularComponent	cell-cell junction	FLNA ARHGAP24 ABCB1 FAT2 NDRG1 PDLIM3 PTPRJ PTPRM KIRREL1	1.83e-03	591	98	9	GO:0005911
Domain	GBP_C	GBP6 GBP1 GBP3	1.49e-05	10	95	3	PF02841
Domain	G_GB1_RHD3_dom	GBP6 GBP1 GBP3	2.04e-05	11	95	3	IPR030386
Domain	Guanylate-bd_N	GBP6 GBP1 GBP3	2.04e-05	11	95	3	IPR015894
Domain	Guanylate-bd_C	GBP6 GBP1 GBP3	2.04e-05	11	95	3	IPR003191
Domain	GBP	GBP6 GBP1 GBP3	2.04e-05	11	95	3	PF02263
Domain	G_GB1_RHD3	GBP6 GBP1 GBP3	2.04e-05	11	95	3	PS51715
Domain	Coatomer_g_Cpla	COPG1 COPG2	2.56e-05	2	95	2	IPR032154
Domain	-	COPG1 COPG2	2.56e-05	2	95	2	2.60.40.1480
Domain	COP-gamma_platf	COPG1 COPG2	2.56e-05	2	95	2	PF08752
Domain	Coatomer_g_Cpla	COPG1 COPG2	2.56e-05	2	95	2	PF16381
Domain	Coatomer_gsu_app_Ig-like-sub	COPG1 COPG2	2.56e-05	2	95	2	IPR013040
Domain	Coatomer_gsu	COPG1 COPG2	2.56e-05	2	95	2	IPR017106
Domain	PLDc	PLD3 PLD2	1.53e-04	4	95	2	PF00614
Domain	Clathrin_a/coatomer_app_sub_C	COPG1 COPG2	1.53e-04	4	95	2	IPR015873
Domain	-	COPG1 COPG2	1.53e-04	4	95	2	3.30.310.30
Domain	PLDc	PLD3 PLD2	3.79e-04	6	95	2	SM00155
Domain	HEAT_REPEAT	COPG1 COPG2 MTOR MROH2B	4.45e-04	70	95	4	PS50077
Domain	PLipase_D/transphosphatidylase	PLD3 PLD2	5.29e-04	7	95	2	IPR001736
Domain	PLD	PLD3 PLD2	5.29e-04	7	95	2	PS50035
Domain	Coatomer/calthrin_app_sub_C	COPG1 COPG2	7.03e-04	8	95	2	IPR009028
Domain	SH3	DOCK4 GAS7 NEB ARHGAP4 ARHGAP27 FGR	8.25e-04	216	95	6	SM00326
Domain	SH3	DOCK4 GAS7 NEB ARHGAP4 ARHGAP27 FGR	8.25e-04	216	95	6	PS50002
Domain	SH3_domain	DOCK4 GAS7 NEB ARHGAP4 ARHGAP27 FGR	9.07e-04	220	95	6	IPR001452
Domain	-	COPG1 CUL9 COPG2 MTOR MROH2B MED12	9.50e-04	222	95	6	1.25.10.10
Domain	Rap_GAP	RAP1GAP2 SIPA1L2	1.12e-03	10	95	2	PF02145
Domain	Galactose-bd-like	EPHA6 CUL9 F8 PTPRM	1.35e-03	94	95	4	IPR008979
Domain	Rap_GAP_dom	RAP1GAP2 SIPA1L2	1.37e-03	11	95	2	IPR000331
Domain	RAPGAP	RAP1GAP2 SIPA1L2	1.37e-03	11	95	2	PS50085
Domain	LamG	FAT3 TSPEAR FAT2	1.45e-03	44	95	3	SM00282
Domain	Coatomer/clathrin_app_Ig-like	COPG1 COPG2	1.63e-03	12	95	2	IPR013041
Domain	Cadherin_CS	PCDHGB2 PCDHGA10 FAT3 FAT2	2.32e-03	109	95	4	IPR020894
Domain	ARM-like	COPG1 CUL9 COPG2 MTOR MROH2B MED12	2.56e-03	270	95	6	IPR011989
Domain	Clathrin/coatomer_adapt-like_N	COPG1 COPG2	2.57e-03	15	95	2	IPR002553
Domain	Adaptin_N	COPG1 COPG2	2.57e-03	15	95	2	PF01602
Domain	CADHERIN_1	PCDHGB2 PCDHGA10 FAT3 FAT2	2.65e-03	113	95	4	PS00232
Domain	Cadherin	PCDHGB2 PCDHGA10 FAT3 FAT2	2.65e-03	113	95	4	PF00028
Domain	CADHERIN_2	PCDHGB2 PCDHGA10 FAT3 FAT2	2.74e-03	114	95	4	PS50268
Domain	-	PCDHGB2 PCDHGA10 FAT3 FAT2	2.74e-03	114	95	4	2.60.40.60
Domain	CA	PCDHGB2 PCDHGA10 FAT3 FAT2	2.82e-03	115	95	4	SM00112
Domain	Cadherin-like	PCDHGB2 PCDHGA10 FAT3 FAT2	2.91e-03	116	95	4	IPR015919
Domain	-	TRPS1 NR4A2 NR1D2	3.06e-03	57	95	3	3.30.50.10
Domain	Cadherin	PCDHGB2 PCDHGA10 FAT3 FAT2	3.10e-03	118	95	4	IPR002126
Domain	Znf_NHR/GATA	TRPS1 NR4A2 NR1D2	3.21e-03	58	95	3	IPR013088
Domain	Laminin_G	FAT3 TSPEAR FAT2	3.21e-03	58	95	3	IPR001791
Domain	RhoGAP	ARHGAP24 ARHGAP4 ARHGAP27	3.88e-03	62	95	3	SM00324
Domain	RhoGAP	ARHGAP24 ARHGAP4 ARHGAP27	4.06e-03	63	95	3	PF00620
Domain	PRAME_family	PRAMEF7 PRAMEF8	4.14e-03	19	95	2	IPR026271
Domain	RhoGAP_dom	ARHGAP24 ARHGAP4 ARHGAP27	4.24e-03	64	95	3	IPR000198
Domain	RHOGAP	ARHGAP24 ARHGAP4 ARHGAP27	4.24e-03	64	95	3	PS50238
Domain	-	ARHGAP24 ARHGAP4 ARHGAP27	4.24e-03	64	95	3	1.10.555.10
Domain	Pkinase_Tyr	ERBB3 EPHA6 ARAF FGR	4.26e-03	129	95	4	PF07714
Domain	ConA-like_dom	FAT3 RANBP9 TSPEAR FAT2 PTPRM	5.22e-03	219	95	5	IPR013320
Domain	Ser-Thr/Tyr_kinase_cat_dom	ERBB3 EPHA6 ARAF FGR	5.41e-03	138	95	4	IPR001245
Domain	CH	CFAP47 FLNA SYNE2	5.46e-03	70	95	3	PF00307
Domain	FCH	GAS7 ARHGAP4	5.53e-03	22	95	2	PF00611
Domain	FCH	GAS7 ARHGAP4	5.53e-03	22	95	2	SM00055
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ERBB3 KDM4C TRPS1 RANBP9 NR4A2 ANKS1B RAP1GAP2 CUL9 GAS7 CS NDRG1 SULF1 MAST1 EIF3D RSBN1L NR1D2 ALPL	1.09e-07	1285	98	17	35914814
Pubmed	Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.	GBP6 GBP1 GBP3	2.16e-07	5	98	3	12396730
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNA ACACA COPG1 NOL11 CUL9 COPG2 YTHDC2 MTOR ATAD2B SYNE2 EIF3D MED12	3.24e-07	653	98	12	22586326
Pubmed	In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.	GBP6 GBP1 GBP3	1.20e-06	8	98	3	16689661
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ACACA EXPH5 YTHDC2 NEB ARAF DNAI1 VPS35 FGA MED12 RSBN1L	1.48e-06	497	98	10	36774506
Pubmed	Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.	GBP6 GBP1 GBP3	3.52e-06	11	98	3	18025219
Pubmed	ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers.	ERBB3 ARAF	7.86e-06	2	98	2	35302851
Pubmed	PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models.	ABCB1 MTOR	7.86e-06	2	98	2	27553832
Pubmed	mTOR Regulation of N-Myc Downstream Regulated 1 (NDRG1) Phosphorylation in Clear Cell Renal Cell Carcinoma.	NDRG1 MTOR	7.86e-06	2	98	2	37298315
Pubmed	BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication.	RAD51 HEXIM1	7.86e-06	2	98	2	30463005
Pubmed	A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines.	ABCB1 MTOR	7.86e-06	2	98	2	32061787
Pubmed	The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1.	GBP1 GBP3	7.86e-06	2	98	2	7518790
Pubmed	The role of FilGAP-filamin A interactions in mechanoprotection.	FLNA ARHGAP24	7.86e-06	2	98	2	19144823
Pubmed	Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell-cell adhesion.	ITGAV PTPRM	7.86e-06	2	98	2	17965016
Pubmed	Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration.	MTOR PLD2	7.86e-06	2	98	2	27280401
Pubmed	Trps1 is associated with the multidrug resistance of osteosarcoma by regulating MDR1 gene expression.	TRPS1 ABCB1	7.86e-06	2	98	2	24491996
Pubmed	Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.	FLNA ARHGAP24	7.86e-06	2	98	2	19293932
Pubmed	Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.	NR4A2 CUBN LRRC55 FZD8 SIPA1L2 ENOX2	7.91e-06	166	98	6	19906978
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF148 FAT3 TRPS1 RANBP9 CUL9 GAS7 YTHDC2 ARAF ARHGAP4 BRD8 SIPA1L2 RSBN1L ALPL	1.54e-05	1116	98	13	31753913
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	PMS1 ERBB3 ARHGAP24 EPHA6 KDM4C ANKS1B CUL9 ATAD2B KIRREL1 TRAPPC9 RSBN1L	1.90e-05	814	98	11	23251661
Pubmed	A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.	GBP6 GBP1 GBP3	2.03e-05	19	98	3	21551061
Pubmed	GTPase properties of the interferon-induced human guanylate-binding protein 2.	GBP1 GBP3	2.35e-05	3	98	2	8706832
Pubmed	Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.	FAT3 FAT2	2.35e-05	3	98	2	15744052
Pubmed	Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.	GBP1 GBP3	2.35e-05	3	98	2	32620042
Pubmed	[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].	GBP1 GBP3	2.35e-05	3	98	2	29089068
Pubmed	Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients.	ERBB3 MTOR	2.35e-05	3	98	2	29233126
Pubmed	mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles.	COPG1 TRAPPC9	2.35e-05	3	98	2	19656848
Pubmed	Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.	GBP1 GBP3	2.35e-05	3	98	2	1715024
Pubmed	Two families of GTPases dominate the complex cellular response to IFN-gamma.	GBP1 GBP3	2.35e-05	3	98	2	9862701
Pubmed	Vitronectin-αvβ3 integrin engagement directs hypoxia-resistant mTOR activity and sustained protein synthesis linked to invasion by breast cancer cells.	ITGAV MTOR	2.35e-05	3	98	2	23722547
Pubmed	The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.	GBP1 GBP3	2.35e-05	3	98	2	11726669
Pubmed	IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.	IQCJ IQCJ-SCHIP1	2.35e-05	3	98	2	17045569
Pubmed	GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.	GBP1 GBP3	2.35e-05	3	98	2	38636926
Pubmed	GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.	MTOR VPS35	2.35e-05	3	98	2	19553991
Pubmed	FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.	FLNA ARHGAP24	2.35e-05	3	98	2	16862148
Pubmed	Cardiac malformations and midline skeletal defects in mice lacking filamin A.	FLNA ERBB3	2.35e-05	3	98	2	16825286
Pubmed	The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.	ERBB3 NDRG1	2.35e-05	3	98	2	26534963
Pubmed	Phospholipase D confers rapamycin resistance in human breast cancer cells.	MTOR PLD2	2.35e-05	3	98	2	12813467
Pubmed	Significance of integrin αvβ5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin.	ERBB3 ITGAV	2.35e-05	3	98	2	20626753
Pubmed	Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.	FLNA ARHGAP24	2.35e-05	3	98	2	21926999
Pubmed	Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain.	GBP1 GBP3	2.35e-05	3	98	2	15717119
Pubmed	Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.	GBP1 GBP3	2.35e-05	3	98	2	35383115
Pubmed	Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.	COPG1 COPG2	2.35e-05	3	98	2	11893085
Pubmed	Role of GTP binding, isoprenylation, and the C-terminal α-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2.	GBP1 GBP3	2.35e-05	3	98	2	20950129
Pubmed	Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.	GBP1 GBP3	2.35e-05	3	98	2	30062052
Pubmed	Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.	GBP1 GBP3	2.35e-05	3	98	2	26416908
Pubmed	Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.	GBP1 GBP3	2.35e-05	3	98	2	32354743
Pubmed	Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.	GBP1 GBP3	2.35e-05	3	98	2	23248289
Pubmed	SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.	RAD51 FLNA	2.35e-05	3	98	2	27391408
Pubmed	Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2.	GBP1 GBP3	2.35e-05	3	98	2	36639389
Pubmed	The Influence of MDR1 Expression Regulated by miR-138 through TRPS1 Signaling Pathway on Multidrug Resistance of Osteosarcoma and Formation of Bacterial Infection Biofilm.	TRPS1 ABCB1	2.35e-05	3	98	2	37571901
Pubmed	The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation.	GBP1 GBP3	2.35e-05	3	98	2	16914101
Pubmed	The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.	GBP1 GBP3	2.35e-05	3	98	2	22730319
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RAD51 FLNA ZNF148 ACACA TRPS1 COPG2 ARAF MED12	2.50e-05	418	98	8	34709266
Pubmed	An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.	GBP6 GBP1 GBP3	2.78e-05	21	98	3	19158679
Pubmed	Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.	CUL9 BPIFB6 PLD3 SYNE2	3.74e-05	66	98	4	15790807
Pubmed	Aberrant mTOR/autophagy/Nurr1 signaling is critical for TSC-associated tumor development.	NR4A2 MTOR	4.70e-05	4	98	2	34463540
Pubmed	MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR.	FLNA MTOR	4.70e-05	4	98	2	25277454
Pubmed	Integrin alphavbeta6 mediates HT29-D4 cell adhesion to MMP-processed fibrinogen in the presence of Mn2+.	ITGAV FGA	4.70e-05	4	98	2	17275949
Pubmed	The bovine B and C blood group systems are not likely to be the orthologues of human RH: an interesting twist in the comparative map.	FGR ALPL	4.70e-05	4	98	2	7943979
Pubmed	Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise.	ACACA MTOR	4.70e-05	4	98	2	23000302
Pubmed	Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway.	MTOR PLD2	4.70e-05	4	98	2	22024166
Pubmed	cDNA for the beta 1 subunit of guanyl nucleotide-binding regulatory proteins from mouse adrenal glands.	GBP1 GBP3	4.70e-05	4	98	2	8917111
Pubmed	Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells.	ABCB1 MTOR	4.70e-05	4	98	2	26460589
Pubmed	mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition.	ERBB3 MTOR	4.70e-05	4	98	2	33273014
Pubmed	Anti-angiogenic effects of thioridazine involving the FAK-mTOR pathway.	ITGAV MTOR	4.70e-05	4	98	2	23022044
Pubmed	The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.	GBP1 GBP3	4.70e-05	4	98	2	39337476
Pubmed	A TORC2-Akt Feed-Forward Topology Underlies HER3 Resiliency in HER2-Amplified Cancers.	ERBB3 MTOR	4.70e-05	4	98	2	26438156
Pubmed	Interaction of CCN1 with αvβ3 integrin induces P-glycoprotein and confers vinblastine resistance in renal cell carcinoma cells.	ITGAV ABCB1	4.70e-05	4	98	2	23744557
Pubmed	Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function.	MTOR PLD2	4.70e-05	4	98	2	20410302
Pubmed	KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.	MTOR KIRREL1	4.70e-05	4	98	2	37909722
Pubmed	Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon.	GBP1 GBP3	4.70e-05	4	98	2	7823961
Pubmed	The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction.	ITGAV MTOR	4.70e-05	4	98	2	26621838
Pubmed	Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.	GBP1 GBP3	4.70e-05	4	98	2	36609599
Pubmed	Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family.	GBP1 GBP3	4.70e-05	4	98	2	10386861
Pubmed	Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair.	RAD51 FLNA	4.70e-05	4	98	2	20305393
Pubmed	Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection.	GBP1 GBP3	4.70e-05	4	98	2	38404575
Pubmed	Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.	ACACA MTOR	4.70e-05	4	98	2	17631500
Pubmed	Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo.	FLNA NEB	4.70e-05	4	98	2	16902413
Pubmed	The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.	YTHDC2 FZD8 SULF1	4.77e-05	25	98	3	35874829
Pubmed	Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.	GBP6 GBP1 GBP3	4.77e-05	25	98	3	35139355
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PMS1 FLNA ZNF148 ACACA COPG2 YTHDC2 NDRG1 PDLIM3 EIF3D SIPA1L2 RSBN1L	6.60e-05	934	98	11	33916271
Pubmed	Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.	ERBB3 NDRG1 MTOR	7.52e-05	29	98	3	26633882
Pubmed	Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments.	IQCJ IQCJ-SCHIP1	7.82e-05	5	98	2	18550753
Pubmed	PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals.	MTOR PLD2	7.82e-05	5	98	2	16837165
Pubmed	Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages.	GBP1 GBP3	7.82e-05	5	98	2	9858320
Pubmed	TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.	GBP1 GBP3	7.82e-05	5	98	2	30858199
Pubmed	Unique features of different members of the human guanylate-binding protein family.	GBP1 GBP3	7.82e-05	5	98	2	17266443
Pubmed	Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.	GBP1 GBP3	7.82e-05	5	98	2	21151871
Pubmed	Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection.	GBP1 GBP3	7.82e-05	5	98	2	31964735
Pubmed	Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.	ERBB3 NDRG1	7.82e-05	5	98	2	27793840
Pubmed	Identification of mRNAs that continue to associate with polysomes during hypoxia.	NDRG1 MTOR	7.82e-05	5	98	2	17488873
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	RAD51 FLNA ERBB3 F8 ARAF MTOR FGA	8.94e-05	371	98	7	25241761
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	ERBB3 GAS7 ITGAV NDRG1 PTPRJ PTPRM KIRREL1	9.88e-05	377	98	7	38117590
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	PMS1 COPG1 RANBP9 COPG2	1.10e-04	87	98	4	17148452
Pubmed	The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways.	SHOC2 MTOR	1.17e-04	6	98	2	30865892
Pubmed	Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum.	COPG1 COPG2	1.17e-04	6	98	2	11884415
Pubmed	Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.	GAS7 ARHGAP4	1.17e-04	6	98	2	26702831
Pubmed	Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.	GBP1 GBP3	1.17e-04	6	98	2	21757726
Pubmed	Identification and characterization of novel isoforms of COP I subunits.	COPG1 COPG2	1.17e-04	6	98	2	11056392
Interaction	DRD1 interactions	FLNA COPG1 RANBP9 COPG2 VPS35	7.31e-08	23	97	5	int:DRD1
Interaction	RPS6KA1 interactions	DOCK4 GBP6 ACACA COPG1 NR4A2 ARAF MTOR MAST1	1.44e-05	228	97	8	int:RPS6KA1
Interaction	CCDC107 interactions	COPG1 EXPH5 HEXIM1 ALG8 PLD2	1.91e-05	68	97	5	int:CCDC107
Cytoband	1p22.2	GBP6 GBP1 GBP3	2.88e-05	28	97	3	1p22.2
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP24 ARHGAP4 ARHGAP27	6.40e-04	50	61	3	721
GeneFamily	Dyneins, axonemal	DNAH2 DNAI1	1.47e-03	17	61	2	536
GeneFamily	Cadherin related	FAT3 FAT2	1.47e-03	17	61	2	24
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRJ PTPRM	2.26e-03	21	61	2	813
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	GAS7 ARHGAP4	2.71e-03	23	61	2	1288
GeneFamily	PRAME family	PRAMEF7 PRAMEF8	2.95e-03	24	61	2	686
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	PMS1 DOCK4 ERBB3 ZNF148 EXPH5 SHOC2 FAT2 BRD8 METTL18	1.77e-06	300	97	9	M8702
Coexpression	HE_LIM_SUN_FETAL_LUNG_C3_OMD_POS_ENDOTHELIAL_CELL	NR4A2 GBP1 CUBN PI15 FZD8 ARHGAP4 PDLIM3 PTPRJ SULF1	6.95e-06	355	97	9	M45758
Coexpression	GSE25123_WT_VS_PPARG_KO_MACROPHAGE_IL4_STIM_DN	ERBB3 EXPH5 NR4A2 RAP1GAP2 NEB ITGAV STX11	9.75e-06	200	97	7	M7958
Coexpression	SEKI_INFLAMMATORY_RESPONSE_LPS_UP	GBP6 GBP1 GBP3 ABCB1 STX11	1.82e-05	87	97	5	MM1253
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK4 ARHGAP24 ACACA KDM4C ANKS1B PTPRJ PTPRM TRAPPC9	1.17e-08	196	97	8	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA TRPM2 RAP1GAP2 ARHGAP4 PTPRJ FGR	1.25e-06	157	97	6	0ad242320ada7bcb9e29548d3050bf4fd3a07115
ToppCell	facs-Lung-Endomucin-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA TRPM2 RAP1GAP2 ARHGAP4 PTPRJ FGR	1.25e-06	157	97	6	fe4c9556806203e57522d1986754ebe5a20aa2de
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGSL1 EPHA6 FAT3 ANKS1B GBP1 NEB	1.50e-06	162	97	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR ITGAV SULF1 KIRREL1 IQCJ-SCHIP1	1.85e-06	168	97	6	fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR ITGAV SULF1 KIRREL1 IQCJ-SCHIP1	1.85e-06	168	97	6	e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CFAP47 EPHA6 EXPH5 TSPEAR RAP1GAP2 ALPL	3.03e-06	183	97	6	c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	SIDT1 F8 ARHGAP4 PTPRM SYNE2 SIPA1L2	3.43e-06	187	97	6	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 ITGAV PTPRJ SYNE2 KIRREL1 NRSN1	3.65e-06	189	97	6	8c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 ITGAV PTPRJ SYNE2 KIRREL1 NRSN1	3.65e-06	189	97	6	5d902a4660a27548764bf04c6de152b565da835c
ToppCell	15\|World / Age, Tissue, Lineage and Cell class	ERBB3 EXPH5 DNAH2 PI15 HEXIM1 PDLIM3	4.12e-06	193	97	6	a8ad0de955494d6f5929dc44ba46627d06d95453
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK4 F8 PTPRM SULF1 SYNE2 ALPL	4.63e-06	197	97	6	e8e879b7634a29569061d3515d180784094a31e7
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK4 ARHGAP24 ACACA KDM4C PTPRM TRAPPC9	4.77e-06	198	97	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Children_(3_yrs)-Immune-monocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPS1 RAP1GAP2 GAS7 PTPRJ ARHGAP27 FGR	5.05e-06	200	97	6	881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GABRG3 RAP1GAP2 FAT2 FGR STX11	1.70e-05	146	97	5	b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCell	E16.5-samps-Myeloid-Macrophage\|E16.5-samps / Age Group, Lineage, Cell class and subclass	TRPM2 DNAH2 ANKS1B GBP3 ARHGAP4	1.82e-05	148	97	5	cd5f697d8c2f272be1f3f52a05446749278431c5
ToppCell	E16.5-samps-Myeloid-Macrophage-CD163+_Macrophage\|E16.5-samps / Age Group, Lineage, Cell class and subclass	TRPM2 DNAH2 ANKS1B GBP3 ARHGAP4	1.82e-05	148	97	5	56e146980a71b5ca655118ae13310c5949220d4a
ToppCell	Striatum-Neuronal-Inhibitory\|Striatum / BrainAtlas - Mouse McCarroll V32	SIDT1 LRRC55 MAST1 NRSN1 CCDC136	2.41e-05	157	97	5	c41ff3fe9de7187575114febfe9bd8733366fb8a
ToppCell	FLU-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	SIDT1 GBP1 GBP3 F8 SYNE2	2.57e-05	159	97	5	97c8e16a7ac10ebba96daee97f9fb1d4a404f23b
ToppCell	FLU-Healthy-1\|FLU / Virus stimulation, Condition and Cluster	SIDT1 GBP1 GBP3 F8 SYNE2	2.57e-05	159	97	5	fe2a9f79b058e89214256e736f6e266830cdfa28
ToppCell	Control-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NR4A2 GAS7 NT5C3B NEB FGR	2.81e-05	162	97	5	aa80452b972bb8ad3670ffaba4ce26fadb33b185
ToppCell	facs-Lung-EPCAM-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA RAP1GAP2 ITGAV PTPRJ FGR	2.81e-05	162	97	5	484ea4ac40de672dcbd2583a52cb7f385c918814
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA RAP1GAP2 ITGAV PTPRJ FGR	2.81e-05	162	97	5	bba144ac5332bab9eba2ccf599703c781a7f88f1
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 ACACA TRPM2 MTOR SIPA1L2	3.25e-05	167	97	5	528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 ACACA TRPM2 MTOR SIPA1L2	3.25e-05	167	97	5	a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	3.34e-05	168	97	5	315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAS7 PI15 PDLIM3 SULF1 KCNT1	3.63e-05	171	97	5	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GBP6 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	3.74e-05	172	97	5	381ae1c3c07d0a424f43455ec571653b192a946a
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FAT3 ANKS1B PI15 PDLIM3 IQCJ	3.84e-05	173	97	5	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GBP6 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	3.95e-05	174	97	5	dbdcdec08f1fc69fcdb5d8a6d78df8ef9c374d89
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	4.28e-05	177	97	5	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CUBN NDRG1 PDLIM3 PTPRM SULF1	4.28e-05	177	97	5	d68132e145bd413404fdbe215b5dbe520e756e50
ToppCell	LPS-antiTNF-Myeloid-Neutrophils-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK4 TRPM2 PTPRJ FGR STX11	4.40e-05	178	97	5	afcc92e8fe313c85eaf617cf4dbc3058da6c99d6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	4.40e-05	178	97	5	edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell	LPS-antiTNF-Myeloid-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK4 TRPM2 PTPRJ FGR STX11	4.40e-05	178	97	5	bd689205bc92cda5f71df64c2332ff76adcd84b4
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG3 TRPM2 KIRREL1 NRSN1 CCDC136	4.40e-05	178	97	5	30ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK4 F8 PTPRM SYNE2 SIPA1L2	4.64e-05	180	97	5	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	FLNA FAT3 PI15 PDLIM3 SULF1	4.64e-05	180	97	5	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	LPS_only-Myeloid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRPM2 GAS7 PTPRJ FGR STX11	4.89e-05	182	97	5	666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	FAT3 ANKS1B PI15 PDLIM3 SULF1	4.89e-05	182	97	5	ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	5.02e-05	183	97	5	612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	5.02e-05	183	97	5	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	5.02e-05	183	97	5	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	FLNA FAT3 ANKS1B PI15 PDLIM3	5.02e-05	183	97	5	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCB1 SYNE2 FGR STX11 ALPL	5.28e-05	185	97	5	03df43e9c2ce4ec24ffed8e4e2993f94ba951c8b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial-Endo_L2-5_CLDN5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCB1 SYNE2 FGR STX11 ALPL	5.28e-05	185	97	5	dbdbd6593cd98550238519746bb45fbf0617550b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	5.28e-05	185	97	5	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	5.28e-05	185	97	5	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	COVID-19-Endothelial_cells-Systemic_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	F8 ABCB1 NDRG1 PTPRM SYNE2	5.28e-05	185	97	5	f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 TSPEAR SULF1 KIRREL1 IQCJ-SCHIP1	5.28e-05	185	97	5	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Endo\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCB1 SYNE2 FGR STX11 ALPL	5.28e-05	185	97	5	de2c24719946d5a37a982d816776cea7f3984c49
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial-Endo_L2-5_CLDN5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GBP1 ABCB1 SYNE2 FGR ALPL	5.42e-05	186	97	5	422d24e3e1a9397bb7d5c7ef75de2fd7ae8e136d
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined\|Fibroblasts / Location, Cell class and cell subclass	ACACA GBP1 GBP3 NT5C3B ENOX2	5.42e-05	186	97	5	403ac98f72a42721f84fbd7826f251a88ae534a2
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Endo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GBP1 ABCB1 SYNE2 FGR ALPL	5.42e-05	186	97	5	65da0666a10a59f8cc379589860a2e98fe487754
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GBP1 ABCB1 SYNE2 FGR ALPL	5.42e-05	186	97	5	dc84fef1ca2f5d5d818b76a3321559e87d1c4a4d
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 ANKS1B ITGAV SULF1 KIRREL1	5.56e-05	187	97	5	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	LPS-IL1RA+antiTNF-Myeloid\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRPM2 GAS7 PTPRJ FGR STX11	5.56e-05	187	97	5	4e0bbef6ba0d1b3e1f8d900d4a9dbd41f09a7bc5
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGAP24 TRPS1 ANKS1B GAS7 SULF1	5.70e-05	188	97	5	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 ANKS1B ITGAV SULF1 KIRREL1	5.70e-05	188	97	5	047c4e0b03fc8334e38c48977e41d26dbe229d47
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 ERBB3 EPHA6 EXPH5 RAP1GAP2	5.85e-05	189	97	5	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHA6 CUBN ABCB1 SYNE2 IQCJ-SCHIP1	5.85e-05	189	97	5	28b502611829e4a24caff2562545c7db97686099
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ANKS1B PI15 PDLIM3 SULF1	5.99e-05	190	97	5	2e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SIDT1 ARHGAP4 ARHGAP27 FGR ALPL	5.99e-05	190	97	5	1307688255a1250fa300edf2c41f1affe31dcc98
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ANKS1B PI15 PDLIM3 SULF1	5.99e-05	190	97	5	0028f886c789ba238c031eae5d96acaed4af8c25
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 PI15 SLC39A12 PDLIM3 SULF1	5.99e-05	190	97	5	1803b1e7c36285f9eaabc3c6e9a9752c5908db3d
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	DOCK4 ARHGAP24 FAT3 GBP1 PTPRM	5.99e-05	190	97	5	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FASTKD1 CS METTL18 TBCK HERC3	5.99e-05	190	97	5	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	TRPM2 TRPS1 ARHGAP4 PTPRJ FGR	6.15e-05	191	97	5	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	TRPM2 TRPS1 GAS7 FGR STX11	6.15e-05	191	97	5	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 ERBB3 EPHA6 EXPH5 RAP1GAP2	6.15e-05	191	97	5	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	Adult-Immune-monocyte-D175\|Adult / Lineage, Cell type, age group and donor	TRPM2 RAP1GAP2 GAS7 PTPRJ FGR	6.15e-05	191	97	5	cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GABRG3 TRPS1 GAS7 PDLIM3 SULF1	6.15e-05	191	97	5	1caf726bd07fdca389e678fc16304a6ef1790423
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GABRG3 TRPS1 GAS7 PDLIM3 SULF1	6.15e-05	191	97	5	3d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 ANKS1B ITGAV SULF1 KIRREL1	6.30e-05	192	97	5	ef0aba777072429a6ab7dcfcc305673975946580
ToppCell	Control-B_intermediate-10\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NR4A2 GAS7 NT5C3B NEB FGR	6.30e-05	192	97	5	224bd958369ba8fa0d7be2126f7dc61c9f6ac19d
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GABRG3 TRPS1 GAS7 PDLIM3 SULF1	6.30e-05	192	97	5	9333aba0d04203ccccad78d82bf6359922f810a7
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	CUBN PTPRJ PTPRM SYNE2 TRAPPC9	6.30e-05	192	97	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FASTKD1 CS METTL18 TBCK HERC3	6.30e-05	192	97	5	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DOCK4 KDM4C PTPRJ PTPRM TRAPPC9	6.46e-05	193	97	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 ANKS1B ITGAV SULF1 KIRREL1	6.46e-05	193	97	5	3eaa0461618582a1754400624350d269d24e750a
ToppCell	Children_(3_yrs)-Immune-monocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPM2 TRPS1 RAP1GAP2 GAS7 PTPRJ	6.46e-05	193	97	5	58e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK4 GABRG3 FAT3 ANKS1B GAS7	6.61e-05	194	97	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	nucseq-Immune-Immune_Myeloid-pMON-pMON\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RAP1GAP2 GAS7 PTPRJ ARHGAP27 FGR	6.61e-05	194	97	5	e237384b02be460d44eeada3026a5691c66f6fc1
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CUBN F8 ARHGAP4 PTPRJ SULF1	6.61e-05	194	97	5	582db7f7fa9aa08027ae18ed607945b5d1dc908a
ToppCell	nucseq-Immune-Immune_Myeloid-pMON\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RAP1GAP2 GAS7 PTPRJ ARHGAP27 FGR	6.61e-05	194	97	5	0bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 ERBB3 EXPH5 RAP1GAP2 IQCJ-SCHIP1	6.61e-05	194	97	5	6b286992d4bb56013c0ea5a7601d3476d806175a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP47 ERBB3 EPHA6 EXPH5 RAP1GAP2	6.61e-05	194	97	5	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM3 SULF1 FGA KIRREL1 SIPA1L2	6.61e-05	194	97	5	1374600957c7d7f0b05fd2c1186f521b9096d4ef
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CUBN F8 ARHGAP4 PTPRJ SULF1	6.61e-05	194	97	5	bda89111386398a072b70e8153b2a762298a047a
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPS1 ITGAV PTPRJ FGR SIPA1L2	6.78e-05	195	97	5	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	ARHGAP24 TRPS1 ANKS1B GAS7 SULF1	6.78e-05	195	97	5	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	metastatic_Brain-T/NK_cells-NK\|T/NK_cells / Location, Cell class and cell subclass	FLNA NR4A2 RAP1GAP2 GAS7 FGR	6.78e-05	195	97	5	184471f71b8bbffec12ebb8dd6a0af589e021c02
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	TRPM2 TRPS1 GAS7 FGR STX11	6.78e-05	195	97	5	ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCell	Children_(3_yrs)-Immune-monocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPS1 RAP1GAP2 GAS7 PTPRJ FGR	6.94e-05	196	97	5	cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 TRPM2 TRPS1 GAS7 FGR	7.11e-05	197	97	5	8af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ARHGAP24 SIDT1 NR4A2 HEXIM1 ALPL	7.11e-05	197	97	5	fd5fdc5289d681d59ff22d72e4de6e74c6c7aac6
ToppCell	T_cells-CTLs\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	FLNA RAP1GAP2 GBP1 SYNE2 FGR	7.11e-05	197	97	5	28117cf300e169182571fbad0de1681a484a435a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 TRPM2 GAS7 FGR STX11	7.11e-05	197	97	5	1eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	DOCK4 F8 ABCB1 PTPRM SYNE2	7.11e-05	197	97	5	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	remission-NK\|World / disease stage, cell group and cell class	FLNA RAP1GAP2 ABCB1 SYNE2 FGR	7.28e-05	198	97	5	383ed78164ad37826100d3de6c3cc14f62e01813
Drug	chicoric acid	ACACA CS MTOR	1.44e-06	6	96	3	ctd:C100435
Drug	methylcyclohexane	FLNA NDRG1 ALPL	5.99e-06	9	96	3	CID000007962
Drug	beta-propiolactone	ACACA PI15 F8 FGA	9.75e-06	32	96	4	CID000002365
Drug	1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one	ERBB3 ABCB1 MTOR FGR	1.25e-05	34	96	4	ctd:C569670
Drug	AC1ND2OB	RAD51 ARAF ABCB1 BRD8 CS MTOR FGR MED12	1.66e-05	265	96	8	CID004568637
Disease	childhood trauma measurement, alcohol consumption measurement	GABRG3 PCDHGB2 PCDHGA10 CS HERC3	3.08e-06	71	93	5	EFO_0007878, EFO_0007979
Disease	FG syndrome (is_implicated_in)	FLNA MED12	2.94e-05	3	93	2	DOID:14711 (is_implicated_in)
Disease	FG SYNDROME 4 (disorder)	FLNA MED12	2.94e-05	3	93	2	C1845546
Disease	FG SYNDROME 2	FLNA MED12	2.94e-05	3	93	2	C1845902
Disease	FG SYNDROME 3	FLNA MED12	2.94e-05	3	93	2	C1845567
Disease	FG syndrome	FLNA MED12	2.94e-05	3	93	2	C0220769
Disease	FG syndrome	FLNA MED12	5.87e-05	4	93	2	cv:C0220769
Disease	nucleotide measurement	ANKS1B SULF1 SYNE2 SIPA1L2	8.52e-05	73	93	4	EFO_0010513
Disease	Malignant Cystosarcoma Phyllodes	FLNA MED12	9.77e-05	5	93	2	C0600066
Disease	Phyllodes Tumor	FLNA MED12	9.77e-05	5	93	2	C0010701
Disease	Malignant neoplasm of breast	RAD51 FLNA ERBB3 CUBN ARAF ABCB1 SLC39A12 NDRG1 MTOR SYNE2 PLD2 MED12	1.40e-04	1074	93	12	C0006142
Disease	PR interval	DOCK4 ARHGAP24 UBE3B RAP1GAP2 CUL9 FZD8 SYNE2 SIPA1L2	1.73e-04	495	93	8	EFO_0004462
Disease	thrombocytopenia (implicated_via_orthology)	PTPRJ FGA	2.04e-04	7	93	2	DOID:1588 (implicated_via_orthology)
Disease	corpus callosum anterior volume measurement	TRPS1 IQCJ IQCJ-SCHIP1	2.55e-04	39	93	3	EFO_0010295
Disease	Mammary Carcinoma, Human	RAD51 FLNA ERBB3 ARAF ABCB1 NDRG1 MTOR MED12	2.58e-04	525	93	8	C4704874
Disease	Mammary Neoplasms, Human	RAD51 FLNA ERBB3 ARAF ABCB1 NDRG1 MTOR MED12	2.58e-04	525	93	8	C1257931
Disease	Mammary Neoplasms	RAD51 FLNA ERBB3 ARAF ABCB1 NDRG1 MTOR MED12	2.65e-04	527	93	8	C1458155
Disease	triglyceride change measurement, response to long-chain n-3 PUFA dietary supplementation	IQCJ IQCJ-SCHIP1	2.72e-04	8	93	2	EFO_0007681, EFO_0009308
Disease	kidney disease (implicated_via_orthology)	CUBN KIRREL1 FGR	2.96e-04	41	93	3	DOID:557 (implicated_via_orthology)
Disease	Breast Carcinoma	RAD51 FLNA ERBB3 ARAF ABCB1 NDRG1 MTOR MED12	3.04e-04	538	93	8	C0678222
Disease	temporal lobe epilepsy (implicated_via_orthology)	ABCB1 MTOR	3.49e-04	9	93	2	DOID:3328 (implicated_via_orthology)
Disease	Colon Carcinoma	ERBB3 PTPRJ	3.49e-04	9	93	2	C0699790
Disease	Thrombophilia	F8 FGA	3.49e-04	9	93	2	C0398623
Disease	Squamous cell carcinoma of the head and neck	ABCB1 NDRG1 TBCK	5.99e-04	52	93	3	C1168401
Disease	Malignant Neoplasms	ERBB3 ABCB1 MTOR ENOX2	7.32e-04	128	93	4	C0006826
Disease	hair colour measurement	GABRG3 ARHGAP24 TRPS1 TSPEAR BPIFB6 SHOC2 SYNE2 SIPA1L2	7.33e-04	615	93	8	EFO_0007822
Disease	information processing speed, response to cranial radiation therapy	RGSL1 CUL9 BRD8	8.25e-04	58	93	3	EFO_0004363, EFO_0010950
Disease	congenital heart disease	YTHDC2 IQCJ IQCJ-SCHIP1	8.67e-04	59	93	3	EFO_0005207
Disease	unipolar depression, mood disorder	NR4A2 PTPRJ ATAD2B ARHGAP27	8.69e-04	134	93	4	EFO_0003761, EFO_0004247
Disease	Neoplasm of uncertain or unknown behavior of bladder	ERBB3 MTOR	1.00e-03	15	93	2	C0496930
Disease	phosphoenolpyruvic acid measurement	KDM4C ALPL	1.00e-03	15	93	2	EFO_0010522
Disease	Benign neoplasm of bladder	ERBB3 MTOR	1.00e-03	15	93	2	C0154017
Disease	Carcinoma in situ of bladder	ERBB3 MTOR	1.00e-03	15	93	2	C0154091
Disease	Major Depressive Disorder	ERBB3 NR4A2 ABCB1 MTOR MED12	1.05e-03	243	93	5	C1269683
Disease	susceptibility to vaginal yeast infection measurement	RANBP9 ANKS1B SULF1	1.15e-03	65	93	3	EFO_0008412
Disease	Unipolar Depression	ERBB3 NR4A2 ABCB1 MTOR MED12	1.39e-03	259	93	5	C0041696
Disease	Adrenocortical carcinoma	ABCB1 MED12	1.45e-03	18	93	2	C0206686
Disease	Carcinoma of bladder	ERBB3 MTOR	1.45e-03	18	93	2	C0699885
Disease	age at onset, Parkinson disease	GABRG3 TRPS1	1.45e-03	18	93	2	EFO_0004847, MONDO_0005180
Disease	cardiomyopathy (implicated_via_orthology)	RAD51 ERBB3 ARAF	1.48e-03	71	93	3	DOID:0050700 (implicated_via_orthology)
Disease	osteochondrodysplasia (is_implicated_in)	FLNA TRPS1	1.62e-03	19	93	2	DOID:2256 (is_implicated_in)
Disease	psoriasis	ERBB3 RAP1GAP2 CS SYNE2 FGR	1.75e-03	273	93	5	EFO_0000676
Disease	urinary microalbumin measurement	YTHDC2 CUBN	1.80e-03	20	93	2	EFO_0010967
Disease	end stage renal disease (implicated_via_orthology)	ABCB1 MTOR	1.80e-03	20	93	2	DOID:783 (implicated_via_orthology)
Disease	Hematochezia, response to radiation	GABRG3 LRRC55	1.80e-03	20	93	2	GO_0009314, HP_0002573
Disease	alcohol consumption measurement	ACACA KDM4C UBE3B TRPS1 DNAH2 ANKS1B SLC39A12 PTPRJ MTOR ARHGAP27 NR1D2	1.82e-03	1242	93	11	EFO_0007878
Disease	Disproportionate short stature	FLNA TRPS1 SULF1	1.87e-03	77	93	3	C0878659
Disease	epilepsy (biomarker_via_orthology)	NR4A2 ABCB1	1.98e-03	21	93	2	DOID:1826 (biomarker_via_orthology)
Disease	neuroimaging measurement, brain volume measurement	FAT3 TRPS1 SLC39A12 IQCJ IQCJ-SCHIP1	2.14e-03	286	93	5	EFO_0004346, EFO_0006930
Disease	Parkinson disease	NR4A2 VPS35	2.18e-03	22	93	2	cv:C0030567
Disease	depressive symptom measurement	UBE3B NR4A2 HEXIM1 ATAD2B SYNE2 MED12	2.32e-03	426	93	6	EFO_0007006
Disease	Sarcosine measurement	PCDHGB2 SHOC2	2.38e-03	23	93	2	EFO_0021668
Disease	Parkinson Disease	TRPM2 ABCB1 VPS35	2.48e-03	85	93	3	C0030567
Disease	mental or behavioural disorder	KDM4C TRPS1 SLC39A12 PTPRM	2.51e-03	179	93	4	EFO_0000677
Disease	stomach carcinoma (is_marker_for)	ERBB3 KDM4C	2.59e-03	24	93	2	DOID:5517 (is_marker_for)
Disease	mental development measurement	PCDHGB2 PCDHGA10	2.81e-03	25	93	2	EFO_0008230
Disease	Acute kidney injury	GBP1 GBP3	2.81e-03	25	93	2	HP_0001919
Disease	serum metabolite measurement	GABRG3 RGSL1 EPHA6 KDM4C RAP1GAP2 GBP1 SLC39A12 SYNE2 ALPL	2.97e-03	945	93	9	EFO_0005653
Disease	Antiglaucoma preparations and miotics use measurement	GAS7 PTPRJ	3.04e-03	26	93	2	EFO_0009944

Protein segments in the cluster

Peptide	Gene	Start	Entry
AIFVMLNYNTNSSHA	ERBB3	116	P21860
NIHIVSNYMDFNEDG	NT5C3B	176	Q969T7
QNAVMYNSSDHDVYH	BRD8	781	Q9H0E9
MNTVLNYIFSHAQVT	ACACA	1021	Q13085
QFLDTYDAHNMSVDT	DNAI1	531	Q9UI46
FTSNDVDMETDHYSN	RANBP9	556	Q96S59
NTDHQTQLLYQASAM	RAD51	196	Q06609
YSFENHQLAMDAENN	IQCJ	21	Q1A5X6
TQEQKFEHMYAQSLQ	ABCB1	911	P08183
VNMESVFDYSINSVH	NOL11	521	Q9H8H0
MNHNQEYFEINTSTG	ANKS1B	541	Q7Z6G8
HSNDQTALMFPNYVS	MMP27	226	Q9H306
VVDQTHFYLGSANMD	PLD3	206	Q8IV08
HRSTELTNFYQMVQQ	FAM166C	106	A6NJV1
VQTHSTDDYINANYM	PTPRJ	1086	Q12913
SYNNFSHVPADMFQE	LRRC55	121	Q6ZSA7
FNSVQELVQHYMEVN	FGR	216	P09769
RTMNQAHYTSLINDE	HERC3	391	Q15034
IVLSAQDFYHAMQNI	ATAD2B	646	Q9ULI0
ANNFYSMIQSANSHV	ENOX2	286	Q16206
LQDEMNDHQNTLSYV	KCNT1	1161	Q5JUK3
APYNTTQFLMDDHDQ	HEXIM1	201	O94992
MSTVQELDYEAQQHF	FAT2	2331	Q9NYQ8
YEQFHELQMQVTASD	PCDHGA10	526	Q9Y5H3
NDNAPVFQQTSYMVH	PCDHGB2	446	Q9Y5G2
VFQQTSYMVHVAENN	PCDHGB2	451	Q9Y5G2
LFNYEDMQEITQHFA	NDRG1	76	Q92597
VDTHAVQFNSALDMY	NRSN1	101	Q8IZ57
NIAHMYQVEFEDGSQ	KDM4C	961	Q9H3R0
TFENSENMPFYHQSN	EXPH5	441	Q8NEV8
QHVQFIFDLMEYSLS	MED12	871	Q93074
MTFQFNFTIEDHLEN	METTL18	1	O95568
QQAMDQLYYVTELTH	GBP1	136	P32455
QQAMDQLYYVTELTH	GBP3	136	Q9H0R5
FVYNSMSTINHQALE	GBP6	126	Q6ZN66
EFQASNIMHSINGYV	F8	626	P00451
FSKVYSSMEQLSQHE	MAST1	711	Q9Y2H9
VSMVDYAHNNYQAQS	ALPL	431	P05186
TYDNVHQQFSMMNLD	ARHGAP24	531	Q8N264
TSDNQMFVQFISDHS	CUBN	2186	O60494
TYMPNQFNHDTQDEA	FZD8	51	Q9H461
DMSTNRQQFYHSVQD	ARAF	146	P10398
MTDRHYQQLLDSFNT	DOCK4	926	Q8N1I0
SSINMEYQIDIFFAQ	GABRG3	86	Q99928
NVDEHSVMTYLSQFP	FLNA	251	P21333
TNMLGYTDHQFTELT	CS	241	O75390
NLAMEATYINHNFSQ	EIF3D	311	O15371
ETFMNKENQNHSYSL	ITGAV	936	P06756
MVHYQIVQDTYNSTD	FAT3	2321	Q8TDW7
IATLQHFMDDINYIN	FASTKD1	521	Q53R41
MANTQLDHLHYTTEF	C6orf50	1	Q9HD87
AQEAASSDNIMVQYH	COPG2	181	Q9UBF2
YSVHENQLQMATSLD	BPIFB6	366	Q8NFQ5
VEEGAEYTSHNNMQF	FGA	771	P02671
EYTSHNNMQFSTFDR	FGA	776	P02671
LTINNVMEADFQTHY	KIRREL1	456	Q96J84
QQSFLTAAHMSEQFA	CUL9	1536	Q8IWT3
AQEAASSDNIMVQYH	COPG1	181	Q9Y678
HQDVVTIMTNSYEVF	DNAH2	796	Q9P225
DYFQNLSMHSVSFLE	PRAMEF8	266	Q5VWM4
IITHDQDYSNFSSSM	SLC39A12	281	Q504Y0
LAFAAQQQMSSIEYE	CFAP47	2181	Q6ZTR5
TAVMNNMESFQYHSE	PMS1	216	P54277
NMESFQYHSEESQIY	PMS1	221	P54277
NMVQTEEQYVFIHDA	PTPRM	1136	P28827
VSHVNYTFEIEAMNG	EPHA6	406	Q9UF33
AFTDTQYLQDTMNHV	MTOR	406	P42345
HKDTFMYNQEQQENS	NR1D2	261	Q14995
NFHQNYVATTHMIEQ	NR4A2	151	P43354
ENENSAAFYVMGIVH	RSBN1L	391	Q6PCB5
YLHQEMQNSKENFTT	RGSL1	821	A5PLK6
QMIVSYDEHEVNNTF	RAP1GAP2	246	Q684P5
ILNNYSAQFSLEHMS	SYNE2	4011	Q8WXH0
YTQLRHETDMFNQST	GAS7	426	O60861
SQDKQMLYTNHFTQE	ARHGAP27	401	Q6ZUM4
HYDVQSILFNINEAM	SIPA1L2	331	Q9P2F8
PSQFSTIYSLNMEHN	SHOC2	351	Q9UQ13
VHAQFNTPMQLYSDD	PDLIM3	186	Q53GG5
YSFENHQLAMDAENN	IQCJ-SCHIP1	21	B3KU38
HDFNSVMYEVQSNFR	MROH2B	86	Q7Z745
FTFLNHLAQYSDENM	ARHGAP4	636	P98171
DQEMLNVHNLNYSSS	ALG8	86	Q9BVK2
QAVQAMYQISQEEHS	CCDC136	861	Q96JN2
DYFQNLSMHSVSFLE	PRAMEF7	266	Q5VXH5
FSHNEVLMQYQKTET	ZNF567	191	Q8N184
TYMGNSSTELEQHFL	TRPS1	341	Q9UHF7
QQFSDYHSELNMSSL	TRBV13	96	A0A0A6YYD4
EMGYTSSHLEQNSQL	LINC00643	31	Q86TS7
FENHETVAYEFMSQA	VPS35	596	Q96QK1
TLTFQRAMHDYNQAE	STX11	136	O75558
AMFNYTFQQVQEHTD	TRPM2	1046	O94759
DLDHNVEFNGVYQSM	SIDT1	226	Q9NXL6
NSHVIQEYLTVFSQM	TBCK	586	Q8TEA7
QEYLTVFSQMIAFHD	TBCK	591	Q8TEA7
FSQSVDYGLNESMHL	UBE3B	366	Q7Z3V4
YQVFMLHSNMQTSDQ	YTHDC2	656	Q9H6S0
SMEASEFLQNAVYIN	TRAPPC9	361	Q96Q05
FMYTSHLDLNQDNIQ	ZBTB49	81	Q6ZSB9
AVANSHSYDVEMQVQ	TSPEAR	541	Q8WU66
HSYDVEMQVQNDSYV	TSPEAR	546	Q8WU66
YISQNDMIAILDYHN	PI15	61	O43692
QTSTPFHYLEMQIEN	ERVK-19	236	Q9WJR5
EAQPVHQAYQMSSFE	ZNF148	716	Q9UQR1
FDMNTDPYQLTNTVH	SULF1	801	Q8IWU6
NYHAMTEFLEVSQLS	PLD2	181	O14939
IMNHVLNTSQLASSY	NEB	5851	P20929