Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	neuronal action potential	NPR2 P2RX1 MTOR SCN8A CACNA1H	3.54e-06	63	76	5	GO:0019228
GeneOntologyBiologicalProcess	positive regulation of translation	NIBAN1 AGO2 KHDRBS1 MTOR EIF4G2 LIN28A	2.00e-05	151	76	6	GO:0045727
GeneOntologyBiologicalProcess	transmission of nerve impulse	NPR2 P2RX1 MTOR SCN8A CACNA1H	5.87e-05	112	76	5	GO:0019226
GeneOntologyCellularComponent	INO80-type complex	ACTR8 SRCAP TRRAP	1.42e-04	28	76	3	GO:0097346
GeneOntologyCellularComponent	presynaptic active zone membrane	STX2 P2RX1 SCN8A CACNA1H	1.88e-04	78	76	4	GO:0048787
Domain	ARM-type_fold	AP4E1 NF1 DOCK8 MTOR DOCK9 EIF4G2 UTP20 COPG2 XPO1 TRRAP XPOT	1.20e-07	339	76	11	IPR016024
Domain	ARM-like	AP4E1 NF1 DOCK8 MTOR DOCK10 UTP20 COPG2 XPO1 TRRAP XPOT	1.39e-07	270	76	10	IPR011989
Domain	DUF3398	DOCK8 DOCK9 DOCK10	1.28e-06	6	76	3	PF11878
Domain	DOCK_C/D_N	DOCK8 DOCK9 DOCK10	1.28e-06	6	76	3	IPR021816
Domain	-	AP4E1 NF1 MTOR UTP20 COPG2 XPO1 TRRAP XPOT	3.31e-06	222	76	8	1.25.10.10
Domain	DOCK_C	DOCK8 DOCK9 DOCK10	1.04e-05	11	76	3	IPR010703
Domain	DHR-1_domain	DOCK8 DOCK9 DOCK10	1.04e-05	11	76	3	IPR027007
Domain	DHR_2	DOCK8 DOCK9 DOCK10	1.04e-05	11	76	3	PS51651
Domain	DHR_1	DOCK8 DOCK9 DOCK10	1.04e-05	11	76	3	PS51650
Domain	DOCK-C2	DOCK8 DOCK9 DOCK10	1.04e-05	11	76	3	PF14429
Domain	DHR-2	DOCK8 DOCK9 DOCK10	1.04e-05	11	76	3	IPR027357
Domain	DHR-2	DOCK8 DOCK9 DOCK10	1.04e-05	11	76	3	PF06920
Domain	DOCK	DOCK8 DOCK9 DOCK10	1.04e-05	11	76	3	IPR026791
Domain	FIIND_dom	NLRP1 CARD8	1.63e-05	2	76	2	IPR025307
Domain	FIIND	NLRP1 CARD8	1.63e-05	2	76	2	PF13553
Domain	HEAT_REPEAT	MTOR UTP20 COPG2 XPO1	1.89e-04	70	76	4	PS50077
Domain	FAT	MTOR TRRAP	2.43e-04	6	76	2	PS51189
Domain	FATC	MTOR TRRAP	2.43e-04	6	76	2	PS51190
Domain	Xpo1	XPO1 XPOT	2.43e-04	6	76	2	PF08389
Domain	FAT	MTOR TRRAP	2.43e-04	6	76	2	PF02259
Domain	PIK-rel_kinase_FAT	MTOR TRRAP	2.43e-04	6	76	2	IPR003151
Domain	FATC_dom	MTOR TRRAP	2.43e-04	6	76	2	IPR003152
Domain	PIK_FAT	MTOR TRRAP	2.43e-04	6	76	2	IPR014009
Domain	Exportin-1/Importin-b-like	XPO1 XPOT	2.43e-04	6	76	2	IPR013598
Domain	FATC	MTOR TRRAP	2.43e-04	6	76	2	SM01343
Domain	Coatomer/calthrin_app_sub_C	AP4E1 COPG2	4.50e-04	8	76	2	IPR009028
Domain	Clathrin/coatomer_adapt-like_N	AP4E1 COPG2	1.66e-03	15	76	2	IPR002553
Domain	Adaptin_N	AP4E1 COPG2	1.66e-03	15	76	2	PF01602
Domain	IBN_N	XPO1 XPOT	1.66e-03	15	76	2	PF03810
Domain	HEAT	MTOR UTP20 XPO1	1.70e-03	58	76	3	IPR000357
Domain	-	MTOR TRRAP	1.89e-03	16	76	2	1.10.1070.11
Domain	IBN_N	XPO1 XPOT	1.89e-03	16	76	2	SM00913
Domain	PI3Kc	MTOR TRRAP	1.89e-03	16	76	2	SM00146
Domain	Importin-beta_N	XPO1 XPOT	2.14e-03	17	76	2	IPR001494
Domain	RUN	RUFY1 RUFY3	2.40e-03	18	76	2	SM00593
Domain	PI3/4_kinase_cat_dom	MTOR TRRAP	2.40e-03	18	76	2	IPR000403
Domain	PI3_PI4_kinase	MTOR TRRAP	2.40e-03	18	76	2	PF00454
Domain	PI3_4_KINASE_3	MTOR TRRAP	2.40e-03	18	76	2	PS50290
Domain	PI3_4_KINASE_1	MTOR TRRAP	2.40e-03	18	76	2	PS00915
Domain	PI3_4_KINASE_2	MTOR TRRAP	2.40e-03	18	76	2	PS00916
Domain	RUN	RUFY1 RUFY3	2.67e-03	19	76	2	PS50826
Domain	RUN	RUFY1 RUFY3	2.67e-03	19	76	2	PF02759
Domain	Run_dom	RUFY1 RUFY3	2.67e-03	19	76	2	IPR004012
Domain	USP_1	USP53 USP7 USP4	2.91e-03	70	76	3	PS00972
Domain	UCH	USP53 USP7 USP4	3.03e-03	71	76	3	PF00443
Domain	USP_2	USP53 USP7 USP4	3.03e-03	71	76	3	PS00973
Domain	USP_3	USP53 USP7 USP4	3.16e-03	72	76	3	PS50235
Domain	USP_dom	USP53 USP7 USP4	3.16e-03	72	76	3	IPR028889
Domain	Peptidase_C19_UCH	USP53 USP7 USP4	3.16e-03	72	76	3	IPR001394
Domain	TRAF-like	TRAF7 USP7	4.26e-03	24	76	2	IPR008974
Domain	CARD	NLRP1 CARD8	5.77e-03	28	76	2	PF00619
Domain	CARD	NLRP1 CARD8	7.04e-03	31	76	2	IPR001315
Domain	CARD	NLRP1 CARD8	7.95e-03	33	76	2	PS50209
Pubmed	Defining the membrane proteome of NK cells.	TUBGCP6 NIBAN1 AGO2 NF1 KHDRBS1 DOCK8 MTOR GCC2 DOCK9 DHX38 DDX42 EIF4G2 DOCK10 FADS2 APLP2 ABCD1 XPO1 BIRC6 PRPF40A	6.89e-12	1168	77	19	19946888
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NF1 SBF1 MTOR DHX38 DDX42 USP7 UTP20 COPG2 XPO1 TRRAP BIRC6 PRPF40A XPOT	1.96e-09	653	77	13	22586326
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TUBGCP6 NF1 RPS6KA5 ZNF592 EIF4G2 USP7 UNK UTP20 XPO1 PAK1IP1 TRRAP PRPF40A	1.33e-07	774	77	12	15302935
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	NF1 MTOR COPG2 XPOT	3.75e-07	27	77	4	23027611
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	NF1 KHDRBS1 MTOR DHX38 DDX42 EIF4G2 USP7 UTP20 FASTKD5 APLP2 IDE XPO1 PAK1IP1 PRPF40A XPOT	4.62e-07	1425	77	15	30948266
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	TRAF7 GTF2F2 MTOR GCC2 USP7 FADS2 UNK UTP20 FASTKD5 COPG2 IDE	8.42e-07	754	77	11	33060197
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MACC1 GTF2F2 SBF1 ZNF592 RBM33 DHX38 EIF4G2 USP7 LAMB2 UNK UTP20 COPG2 APLP2 PAK1IP1 TRRAP	8.59e-07	1497	77	15	31527615
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRAF7 SBF1 ZNF592 MTOR DOCK9 SCN8A USP7 LAMB2 CACNA1H ABCD1 SRCAP TRRAP BIRC6	8.75e-07	1105	77	13	35748872
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	GTF2F2 ZNF592 RBM33 DOCK9 USP7 XPO1 TRRAP RUFY1 XPOT	1.58e-06	497	77	9	36774506
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	GTF2F2 ACTR8 KHDRBS1 DDX42 CCDC87 XPO1 SRCAP TRRAP	2.49e-06	390	77	8	17643375
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TUBGCP6 USP53 AGO2 SBF1 ZNF592 KLHL42 UNK KCNT1 RUFY3	2.62e-06	529	77	9	14621295
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK8 DOCK9 DOCK10	3.73e-06	14	77	3	12432077
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	TUBGCP6 ACTR8 SBF1 DHX38 SRCAP TRRAP XPOT	4.75e-06	300	77	7	28561026
Pubmed	CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.	NLRP1 CARD8	4.84e-06	2	77	2	22087307
Pubmed	Direct participation of Sam68, the 68-kilodalton Src-associated protein in mitosis, in the CRM1-mediated Rev nuclear export pathway.	KHDRBS1 XPO1	4.84e-06	2	77	2	12134041
Pubmed	Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas.	FADS2 XPO1	4.84e-06	2	77	2	32851475
Pubmed	Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes.	NLRP1 CARD8	4.84e-06	2	77	2	37311351
Pubmed	1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.	XPO1 XPOT	4.84e-06	2	77	2	16707848
Pubmed	The NLRP1 and CARD8 inflammasomes detect reductive stress.	NLRP1 CARD8	4.84e-06	2	77	2	36649710
Pubmed	Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.	NLRP1 CARD8	4.84e-06	2	77	2	36649711
Pubmed	Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development.	SCN8A KCNT1	4.84e-06	2	77	2	38289338
Pubmed	Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.	MTOR XPO1	4.84e-06	2	77	2	27693556
Pubmed	Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis Type 1.	NF1 MTOR	4.84e-06	2	77	2	21748792
Pubmed	Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.	NLRP1 CARD8	4.84e-06	2	77	2	33420028
Pubmed	Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.	NLRP1 CARD8	4.84e-06	2	77	2	33420033
Pubmed	Sam68 functions in nuclear export and translation of HIV-1 RNA.	KHDRBS1 XPO1	4.84e-06	2	77	2	19535902
Pubmed	Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis.	NLRP1 CARD8	4.84e-06	2	77	2	23053059
Pubmed	De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy.	SCN8A CACNA1H	4.84e-06	2	77	2	34399820
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	AGO2 NF1 SBF1 DHX38 EIF4G2 USP7 DOCK10 UTP20 XPO1 SRCAP TRRAP BIRC6 XPOT	7.99e-06	1353	77	13	29467282
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	DDX42 USP7 XPO1 TRRAP PRPF40A XPOT	9.76e-06	220	77	6	35785414
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	GTF2F2 KHDRBS1 RBM33 DDX42 PRPF40A	1.08e-05	130	77	5	35545047
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	AGO2 KHDRBS1 RBM33 DHX38 DDX42 EIF4G2 UNK UTP20 FASTKD5 PRPF40A	1.16e-05	807	77	10	22681889
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	DHX38 EIF4G2 USP7 USP4 XPO1 TRRAP BIRC6	1.16e-05	344	77	7	30333137
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	GTF2F2 KHDRBS1 ZNF592 DHX38 DDX42 EIF4G2 USP7 XPO1 PAK1IP1 TRRAP PRPF40A	1.41e-05	1014	77	11	32416067
Pubmed	circFADS2 protects LPS-treated chondrocytes from apoptosis acting as an interceptor of miR-498/mTOR cross-talking.	MTOR FADS2	1.45e-05	3	77	2	31141496
Pubmed	Roles of the DOCK-D family proteins in a mouse model of neuroinflammation.	DOCK9 DOCK10	1.45e-05	3	77	2	32241915
Pubmed	Genetic variation in the inflammasome and atopic dermatitis susceptibility.	NLRP1 CARD8	1.45e-05	3	77	2	23563199
Pubmed	Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345.	HUS1 XPO1	1.45e-05	3	77	2	12676962
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	NF1 MTOR GCC2 FASTKD5 COPG2 APLP2 XPO1 BIRC6 XPOT	1.49e-05	657	77	9	36180527
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	AGO2 SBF1 DHX38 USP7 COPG2 APLP2 IDE XPO1 BIRC6 PLK4 XPOT	1.93e-05	1049	77	11	27880917
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP53 NF1 MTOR USP7 USP4	1.95e-05	147	77	5	29576527
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	GTF2F2 ACTR8 KHDRBS1 ZNF592 RBM33 DHX38 TRRAP PRPF40A	2.40e-05	533	77	8	30554943
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	KHDRBS1 DHX38 DDX42 USP7 APLP2	2.59e-05	156	77	5	29961565
Pubmed	SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing.	KHDRBS1 MTOR	2.89e-05	4	77	2	30767021
Pubmed	MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1.	NF1 MTOR	2.89e-05	4	77	2	24509877
Pubmed	Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway.	MTOR LIN28A	2.89e-05	4	77	2	25688987
Pubmed	p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression.	NF1 MTOR	2.89e-05	4	77	2	29392777
Pubmed	The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway.	KHDRBS1 XPO1	2.89e-05	4	77	2	21613532
Pubmed	The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency.	AGO2 BIRC6	2.89e-05	4	77	2	29074849
Pubmed	Differential Dynamics of ATR-Mediated Checkpoint Regulators.	ATRIP HUS1	2.89e-05	4	77	2	20847938
Pubmed	CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.	AGO2 XPO1	2.89e-05	4	77	2	19955415
Pubmed	Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.	NPR2 IL1R2	2.89e-05	4	77	2	26888452
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	KHDRBS1 DDX42 XPO1 BIRC6 PRPF40A LIN28A	3.03e-05	269	77	6	29511261
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	AGO2 NF1 KHDRBS1 DHX38 USP7 FASTKD5 APLP2 XPO1 TRRAP RUFY1 BIRC6 LIN28A	3.36e-05	1327	77	12	32694731
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	NF1 ATRIP CCDC87 DOCK10 UTP20 PAK1IP1 TRRAP	3.56e-05	410	77	7	26949251
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	GTF2F2 UTP20 XPO1 RUFY1 RUFY3 XPOT	4.18e-05	285	77	6	32838362
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TRAF7 RBM33 DHX38 USP7 UNK SRCAP RUFY1 RUFY3	4.81e-05	588	77	8	38580884
Pubmed	Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.	RPS6KA5 MTOR	4.82e-05	5	77	2	11777913
Pubmed	Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis.	MTOR UNK	4.82e-05	5	77	2	36509146
Pubmed	The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis.	USP7 USP4	4.82e-05	5	77	2	31748695
Pubmed	Monoubiquitylation promotes mitochondrial p53 translocation.	USP7 XPO1	4.82e-05	5	77	2	17268548
Pubmed	Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.	DOCK9 DOCK10	4.82e-05	5	77	2	15710388
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	NF1 SBF1 ZNF592 DHX38 PAK1IP1 SRCAP TRRAP	5.55e-05	440	77	7	34244565
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	KHDRBS1 ZNF592 DHX38 DDX42 USP7 FADS2 UTP20 XPO1 PAK1IP1 PRPF40A	6.46e-05	989	77	10	36424410
Pubmed	Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?	SCN8A CACNA1H	7.22e-05	6	77	2	17513486
Pubmed	CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways.	NLRP1 CARD8	7.22e-05	6	77	2	12775719
Pubmed	The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.	DOCK9 DOCK10	7.22e-05	6	77	2	25851601
Pubmed	Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection.	NLRP1 CARD8	7.22e-05	6	77	2	22227487
Pubmed	Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.	AP4E1 COPG2	7.22e-05	6	77	2	11409905
Pubmed	Cessation of HIV-1 transcription by inhibiting regulatory protein Rev-mediated RNA transport.	KHDRBS1 XPO1	7.22e-05	6	77	2	19149559
Pubmed	eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.	MTOR EIF4G2	7.22e-05	6	77	2	18426977
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	KHDRBS1 RBM33 MTOR EIF4G2 USP7 COPG2 XPO1 XPOT	8.49e-05	638	77	8	33239621
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	NIBAN1 NF1 KHDRBS1 DDX42 LAMB2 UTP20 XPO1 SRCAP TRRAP PRPF40A	8.62e-05	1024	77	10	24711643
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	NF1 COPG2 TRRAP XPOT	8.63e-05	104	77	4	31240132
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	AP4E1 NF1 IL1R2 MTOR DDX42 UNK USP4 ABCD1 IDE TRRAP MGAT4C	8.89e-05	1242	77	11	30973865
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	TUBGCP6 AGO2 NF1 RPS6KA5 SCN8A UNK KCNT1	8.95e-05	475	77	7	31040226
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	KLHL42 NLRP1 PAK1IP1	9.72e-05	40	77	3	25011449
Pubmed	Exome sequencing supports a de novo mutational paradigm for schizophrenia.	MTOR FASTKD5 TRRAP	9.72e-05	40	77	3	21822266
Pubmed	The rapid activation of protein synthesis by growth hormone requires signaling through mTOR.	CSHL1 MTOR	1.01e-04	7	77	2	17284572
Pubmed	SPAG5-AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway.	AGO2 MTOR	1.01e-04	7	77	2	31957155
Pubmed	microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling.	CSHL1 MTOR	1.01e-04	7	77	2	36976763
Pubmed	Deubiquitylation and stabilization of PTEN by USP13.	USP7 USP4	1.01e-04	7	77	2	24270891
Pubmed	The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice.	NF1 MTOR	1.01e-04	7	77	2	16906226
Pubmed	Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer.	RPS6KA5 MTOR	1.01e-04	7	77	2	20354165
Pubmed	Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.	NF1 MTOR	1.01e-04	7	77	2	21896734
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	KHDRBS1 ZNF592 DHX38 DDX42 UTP20 XPO1 PAK1IP1 TRRAP PRPF40A	1.06e-04	847	77	9	35850772
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	GTF2F2 KHDRBS1 DHX38 DDX42 SRCAP TRRAP	1.12e-04	341	77	6	32971831
Pubmed	ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.	ATRIP HUS1	1.34e-04	8	77	2	18162465
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	KHDRBS1 SBF1 DDX42 USP7 APLP2 XPO1 PAK1IP1 SRCAP TRRAP PRPF40A	1.35e-04	1082	77	10	38697112
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	RBM33 DOCK9 EIF4G2 SRCAP BIRC6 XPOT	1.58e-04	363	77	6	14691545
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	KHDRBS1 MTOR DHX38 UTP20 COPG2 PAK1IP1 TRRAP BIRC6	1.67e-04	704	77	8	29955894
Pubmed	LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-catenin.	AGO2 USP7	1.72e-04	9	77	2	31527801
Pubmed	The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.	USP7 USP4	1.72e-04	9	77	2	22195557
Pubmed	Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.	NF1 MTOR	1.72e-04	9	77	2	27340174
Pubmed	Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons.	RUFY1 RUFY3	1.72e-04	9	77	2	24720729
Pubmed	Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest.	AGO2 LIN28A	1.72e-04	9	77	2	20014101
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TUBGCP6 TRAF7 ACTR8 AGO2 ZNF592 USP7 FASTKD5 SRCAP TRRAP PRPF40A	1.74e-04	1116	77	10	31753913
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	TRAF7 GTF2F2 AGO2 NF1 RPS6KA5 USP7 FASTKD5 TRRAP PLK4	1.82e-04	910	77	9	36736316
Pubmed	Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.	XPO1 XPOT	2.15e-04	10	77	2	10944119
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	MTOR TRRAP	2.15e-04	10	77	2	18160036
Interaction	SIRT7 interactions	NF1 SBF1 MTOR DHX38 DDX42 USP7 UTP20 COPG2 XPO1 TRRAP BIRC6 PRPF40A XPOT	3.80e-06	744	76	13	int:SIRT7
Interaction	POLR1G interactions	GTF2F2 ZNF592 DHX38 USP7 UTP20 FASTKD5 XPO1 SRCAP TRRAP XPOT	1.47e-05	489	76	10	int:POLR1G
Interaction	ITGB3 interactions	DHX38 EIF4G2 USP7 XPO1 TRRAP BIRC6	4.42e-05	170	76	6	int:ITGB3
Interaction	SF3B3 interactions	TRAF7 SBF1 DDX42 USP7 UNK SRCAP TRRAP RUFY1 PRPF40A PLK4	4.52e-05	558	76	10	int:SF3B3
Interaction	YY1 interactions	ACTR8 AGO2 ZNF592 MTOR DDX42 USP7 SRCAP TRRAP PRPF40A	5.17e-05	454	76	9	int:YY1
Interaction	YEATS4 interactions	GTF2F2 MTOR XPO1 SRCAP TRRAP PRPF40A	6.47e-05	182	76	6	int:YEATS4
Interaction	HTR6 interactions	NF1 MTOR COPG2 XPOT	6.79e-05	58	76	4	int:HTR6
Interaction	RTL5 interactions	RTL5 USP7	8.38e-05	4	76	2	int:RTL5
Interaction	DMAC1 interactions	NF1 MTOR XPO1	8.65e-05	23	76	3	int:DMAC1
Interaction	TNFSF13B interactions	NF1 MTOR XPO1 FAM118A XPOT	8.72e-05	119	76	5	int:TNFSF13B
Interaction	TOP3B interactions	TRAF7 AGO2 SBF1 ZNF592 RBM33 MTOR DOCK9 SCN8A USP7 LAMB2 UNK CACNA1H ABCD1 SRCAP TRRAP BIRC6	9.76e-05	1470	76	16	int:TOP3B
Interaction	RUVBL2 interactions	ACTR8 AGO2 KHDRBS1 MTOR DDX42 CCDC87 USP7 XPO1 SRCAP TRRAP	1.03e-04	616	76	10	int:RUVBL2
Interaction	NPY2R interactions	NT5C1A MTOR FASTKD5 XPO1	1.13e-04	66	76	4	int:NPY2R
Interaction	BSG interactions	DOCK8 MTOR GCC2 USP7 UTP20 FASTKD5 ABCD1 TRRAP RUFY1 XPOT	1.25e-04	631	76	10	int:BSG
Interaction	CTDP1 interactions	GTF2F2 NF1 USP7 COPG2 TRRAP XPOT	1.31e-04	207	76	6	int:CTDP1
Interaction	GPR85 interactions	USP7 UNK	1.39e-04	5	76	2	int:GPR85
Interaction	DOCK10 interactions	DOCK9 USP7 DOCK10	1.58e-04	28	76	3	int:DOCK10
Interaction	NPPB interactions	NPR2 APLP2 TRRAP	1.58e-04	28	76	3	int:NPPB
Interaction	TELO2 interactions	ATRIP MTOR XPO1 TRRAP RUFY1	1.58e-04	135	76	5	int:TELO2
Interaction	VSIG1 interactions	NF1 HUS1 UTP20 RUFY1	1.58e-04	72	76	4	int:VSIG1
Interaction	LPIN3 interactions	NF1 USP7 XPO1 BIRC6	1.67e-04	73	76	4	int:LPIN3
Interaction	RNF126 interactions	MTOR EIF4G2 USP7 KLHL42 XPOT	1.75e-04	138	76	5	int:RNF126
Interaction	LGALS7 interactions	DOCK8 USP7 APLP2 USP4 XPO1	1.81e-04	139	76	5	int:LGALS7
Interaction	NUP98 interactions	USP53 USP7 UNK XPO1 RUFY1 XPOT	1.83e-04	220	76	6	int:NUP98
Interaction	SPDL1 interactions	EIF4G2 FADS2 LAMB2 USP4 XPO1 TRRAP KCNAB3	1.85e-04	315	76	7	int:SPDL1
Interaction	FBXO22 interactions	GTF2F2 ZNF592 RBM33 DOCK9 USP7 XPO1 TRRAP RUFY1 XPOT	1.92e-04	540	76	9	int:FBXO22
GeneFamily	Exportins	XPO1 XPOT	1.89e-04	7	55	2	547
GeneFamily	Ubiquitin specific peptidases	USP53 USP7 USP4	6.59e-04	56	55	3	366
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	NPR2 SBF1	2.61e-03	25	55	2	504
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	NLRP1 CARD8	3.74e-03	30	55	2	959
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	RUFY1 RUFY3	3.99e-03	31	55	2	81
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	DOCK8 DOCK10 XPO1 BIRC6 TMEM200A	1.73e-05	185	77	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GBP4 RTL5 SCN8A CACNA1H TMEM200A	1.73e-05	185	77	5	2a8104f610fa5ce618f8105521616722462a0d42
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	DOCK8 DOCK10 XPO1 BIRC6 TMEM200A	1.78e-05	186	77	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TRAF7 LAMB2 UTP20 FASTKD5 XPOT	1.97e-05	190	77	5	2434b8ad2976eab7d9147012c28454ab29670709
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TRAF7 LAMB2 UTP20 FASTKD5 XPOT	2.02e-05	191	77	5	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell	Children_(3_yrs)-Immune-monocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	P2RX1 DOCK8 IL1R2 DOCK10 NLRP1	2.28e-05	196	77	5	cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NIBAN1 DOCK8 IL1R2 DOCK10 NLRP1	2.28e-05	196	77	5	291c59b609985167c98a40d4e2caeea2fad74941
ToppCell	BL\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NIBAN1 GBP4 DOCK8 IL1R2 CARD8	2.34e-05	197	77	5	1acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NIBAN1 DOCK8 IL1R2 DOCK10 NLRP1	2.34e-05	197	77	5	826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
Drug	Argentine	STX2 NIBAN1 LAMB2 NLRP1 PRPF40A	8.55e-08	33	77	5	CID000442941
Drug	Antipyrine [60-80-0]; Down 200; 21.2uM; MCF7; HT_HG-U133A	NPR2 NF1 RPS6KA5 FADS2 ABCD1 SRCAP PLK4	5.03e-06	199	77	7	1489_DN
Drug	Homochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; MCF7; HT_HG-U133A	STX2 NF1 RPS6KA5 EIF4G2 CACNA1H SRCAP	4.66e-05	191	77	6	7417_UP
Drug	3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; MCF7; HT_HG-U133A	STX2 NPR2 HUS1 APLP2 CARD8 RUFY3	4.80e-05	192	77	6	3382_DN
Drug	Reserpinic acid hydrochloride; Up 200; 9.2uM; MCF7; HT_HG-U133A	AP4E1 NF1 SBF1 ZNF592 EIF4G2 SRCAP	5.23e-05	195	77	6	7323_UP
Drug	Aminopurine, 6-benzyl [1214-39-7]; Down 200; 17.8uM; PC3; HT_HG-U133A	NPR2 NF1 KHDRBS1 HUS1 EIF4G2 DOCK10	5.38e-05	196	77	6	3726_DN
Drug	Dizocilpine maleate [77086-22-7]; Down 200; 11.8uM; MCF7; HT_HG-U133A	STX2 NF1 EIF4G2 CACNA1H PLK4 CERS4	5.38e-05	196	77	6	2232_DN
Drug	Timolol maleate salt [26921-17-5]; Down 200; 9.2uM; PC3; HT_HG-U133A	AP4E1 NF1 DOCK9 EIF4G2 SRCAP PLK4	5.38e-05	196	77	6	4685_DN
Drug	Methacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A	STX2 AP4E1 B3GNT4 NF1 SBF1 CACNA1H	5.38e-05	196	77	6	7321_UP
Drug	2-propylpentanoic acid; Down 200; 50uM; PC3; HT_HG-U133A	STX2 ACTR8 SBF1 EIF4G2 USP7 PLK4	5.38e-05	196	77	6	4446_DN
Drug	Heptaminol hydrochloride [543-15-7]; Up 200; 22uM; MCF7; HT_HG-U133A	AP4E1 B3GNT4 ACTR8 NF1 SRCAP KCNAB3	5.53e-05	197	77	6	6015_UP
Drug	Chloroquine diphosphate [50-63-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A	KHDRBS1 IL1R2 SCN8A DOCK10 CACNA1H SRCAP	5.53e-05	197	77	6	2869_UP
Drug	Hydroflumethiazide [135-09-1]; Down 200; 12uM; MCF7; HT_HG-U133A	TGFB3 NF1 RPS6KA5 MTOR CARD8 RUFY3	5.53e-05	197	77	6	7019_DN
Drug	Corynanthine hydrochloride [66634-44-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A	HUS1 ZNF592 IL1R2 SCN8A CACNA1H ABCD1	5.53e-05	197	77	6	2786_UP
Drug	Diflorasone Diacetate [33564-31-7]; Up 200; 8uM; PC3; HT_HG-U133A	NPR2 NF1 NLRP1 FAM118A SRCAP PLK4	5.53e-05	197	77	6	4077_UP
Drug	SC 19220; Down 200; 10uM; PC3; HT_HG-U133A	NPR2 SBF1 HUS1 RPS6KA5 ABCD1 SRCAP	5.69e-05	198	77	6	7095_DN
Drug	Ornidazole [16773-42-5]; Down 200; 18.2uM; MCF7; HT_HG-U133A	AP4E1 FADS2 CACNA1H SRCAP PLK4 RUFY3	5.69e-05	198	77	6	2272_DN
Drug	Triflusal [322-79-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A	TGFB3 B3GNT4 NF1 SBF1 HUS1 USP7	5.69e-05	198	77	6	7451_UP
Drug	Reserpinic acid hydrochloride; Up 200; 9.2uM; PC3; HT_HG-U133A	NF1 CCDC87 NLRP1 PLK4 CERS4 RUFY3	5.69e-05	198	77	6	6603_UP
Drug	Methotrimeprazine maleat salt [7104-38-3]; Down 200; 9uM; PC3; HT_HG-U133A	AP4E1 NF1 SBF1 EIF4G2 NLRP1 SRCAP	5.85e-05	199	77	6	3701_DN
Drug	PHA-00745360 [351320-33-7]; Down 200; 10uM; MCF7; HT_HG-U133A	AP4E1 B3GNT4 NF1 SBF1 SRCAP RUFY3	6.02e-05	200	77	6	3907_DN
Drug	NSC226080	NT5C1A NIBAN1 AGO2 NF1 RPS6KA5 MTOR EIF4G2 USP7 XPO1 PRPF40A XPOT	6.19e-05	782	77	11	CID000005040
Drug	magnesium oxide	RPS6KA5 C2 KIR3DL1	6.27e-05	23	77	3	CID000014792
Drug	nitroglycerin	NPR2 IL1R2 UTP20 NLRP1 ABCD1 BIRC6	7.09e-05	206	77	6	CID000004510
Drug	28 N	STX2 NPR2 NLRP1	7.15e-05	24	77	3	CID000004551
Disease	Microcephaly and chorioretinopathy	TUBGCP6 PLK4	1.86e-05	3	74	2	cv:CN263236
Disease	Autosomal recessive chorioretinopathy-microcephaly syndrome	TUBGCP6 PLK4	1.86e-05	3	74	2	cv:C3502492
Disease	Microcephaly with Chorioretinopathy, Autosomal Recessive	TUBGCP6 PLK4	1.86e-05	3	74	2	C3502492
Disease	sphingomyeline C18:1 measurement	FADS2 CERS4	6.17e-05	5	74	2	EFO_0801320
Disease	Sphingomyelin (d18:1/20:1, d18:2/20:0) measurement	FADS2 CERS4	9.25e-05	6	74	2	EFO_0022110
Disease	Sphingomyelin (d18:1/18:1, d18:2/18:0) measurement	FADS2 CERS4	9.25e-05	6	74	2	EFO_0022108
Disease	level of Sphingomyelin (d36:2) in blood serum	FADS2 CERS4	1.29e-04	7	74	2	OBA_2045177
Disease	asthma, type 2 diabetes mellitus	FADS2 IDE	1.72e-04	8	74	2	MONDO_0004979, MONDO_0005148
Disease	N-acetylputrescine measurement	TUBGCP6 EIF4G2	4.03e-04	12	74	2	EFO_0800127
Disease	level of Phosphatidylinositol (16:0_18:1) in blood serum	USP7 FADS2	4.03e-04	12	74	2	OBA_2045152
Disease	Profound Mental Retardation	AP4E1 NF1 DOCK8 SCN8A	4.20e-04	139	74	4	C0020796
Disease	Mental Retardation, Psychosocial	AP4E1 NF1 DOCK8 SCN8A	4.20e-04	139	74	4	C0025363
Disease	Mental deficiency	AP4E1 NF1 DOCK8 SCN8A	4.20e-04	139	74	4	C0917816
Disease	colon cancer (is_marker_for)	TGFB3 NF1 PLK4	4.45e-04	59	74	3	DOID:219 (is_marker_for)
Disease	Intellectual Disability	AP4E1 NF1 DOCK8 MTOR SCN8A TRRAP	9.08e-04	447	74	6	C3714756
Disease	level of Sphingomyelin (d38:2) in blood serum	FADS2 CERS4	1.03e-03	19	74	2	OBA_2045179
Disease	Seckel syndrome	ATRIP PLK4	1.39e-03	22	74	2	C0265202
Disease	Primary microcephaly	TUBGCP6 PLK4	1.39e-03	22	74	2	C0431350
Disease	Neurodevelopmental Disorders	DOCK8 SCN8A SRCAP	1.67e-03	93	74	3	C1535926
Disease	cholesteryl ester 14:0 measurement	FADS2 CARD8	2.09e-03	27	74	2	EFO_0010340
Disease	Neurotoxicity Syndromes	P2RX1 MTOR	2.41e-03	29	74	2	C0235032
Disease	Encephalopathy, Toxic	P2RX1 MTOR	2.41e-03	29	74	2	C0149504
Disease	Toxic Encephalitis	P2RX1 MTOR	2.41e-03	29	74	2	C0154659
Disease	Child Development Disorders, Specific	DOCK8 KCNT1	2.41e-03	29	74	2	C0085997
Disease	Child Development Deviations	DOCK8 KCNT1	2.41e-03	29	74	2	C0085996

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSFKKQHICSDFEVM	nan	56	Q0VG73
FKEQVIHHFVAVILM	CERS4	206	Q9HA82
VCFNKLFSMLQVHHV	BIRC6	2641	Q9NR09
IRPHIFFDDQMFHVA	NT5C1A	321	Q9BXI3
GLMFHKAQEFLQHRI	ACTR8	541	Q9H981
FKEAMLQAHRAHQLA	CSHL1	36	Q14406
FELKHMRDVQFNHLT	NPR2	566	P20594
TDFLHVIFQMHEEEV	CCDC87	606	Q9NVE4
EHMVQHFKTQIFGDR	AGO2	76	Q9UKV8
MRQHAFELKHLHENV	AP4E1	586	Q9UPM8
ALAFQQKFHRHMIDL	RBM33	1146	Q96EV2
EMFQVFEDVQRCHFK	ABCD1	421	P33897
FFHKERMEVCENHQH	APLP2	151	Q06481
IFHKDPDVNMLHVFV	FADS2	226	O95864
AMVQDITQKFAHHII	MGAT4C	151	Q9UBM8
LMNFKSFVEELNSHH	LEXM	261	Q3ZCV2
DTKALHQVFEHMLDV	C2	441	P06681
AKHALENMINDFHRA	KCNT1	226	Q5JUK3
AHFGFDEQLMHQIRK	DDX42	256	Q86XP3
SDIMFEHFFLHKEGI	KIR3DL1	146	P43629
HVDTSLFQMAHFKEE	NLRP1	1176	Q9C000
HTEMKEESDIVFHFQ	CLC	41	Q05315
QLDLEAEFHFTHLIM	LAMB2	136	P55268
VFMEHSFKDENHEFQ	GBP4	381	Q96PP9
LQLFKHEMQHFVKVI	TUBGCP6	1666	Q96RT7
EVFHDQLHTFLVMEL	RPS6KA5	486	O75582
EHALMLFGKDFHLIQ	MIER3	291	Q7Z3K6
MQKFLHDHVDLQVSA	EIF4G2	816	P78344
VHQVHLQFPMEFEFS	SBF1	1491	O95248
RIFKDFMHVLEHECQ	PRPF40A	791	O75400
ENEDHFFKHQADMLL	FAM118A	266	Q9NWS6
LVNIVKMFRFTHVDH	FASTKD5	356	Q7L8L6
TDFEMHHNINRFVFE	DOCK10	1966	Q96BY6
FFELLVKSMAQHVHN	DOCK8	986	Q8NF50
FHVDLNHFSVRQMLA	DOCK9	416	Q9BZ29
AHFMLKGDDDVFVHV	B3GNT4	211	Q9C0J1
PSHVLFDHDKFVQMA	FRMPD2	646	Q68DX3
EMDAQHIKDEFFHER	GCC2	366	Q8IWJ2
FLVAHFKNEGMVLEH	CARD8	266	Q9Y2G2
RCIKHMFTNHIVFQF	COPG2	646	Q9UBF2
VHQQFLFSLVEHREM	MACC1	466	Q6ZN28
EHREMHLFDFCVQVE	MACC1	476	Q6ZN28
AHLNMDLHVFIEVFG	KHDRBS1	221	Q07666
HVEDIILHMFQYIQK	IDE	386	P14735
LFMMHCVEVLHQFDQ	ATRIP	736	Q8WXE1
ITHKMFDHVVLVFIF	CACNA1H	1291	O95180
DHLTLMQKVEVFEHA	MTOR	2276	P42345
AEHHLFQREKVEMQL	KCNAB3	256	O43448
VEEVNAAHMKTCLFH	P2RX1	206	P51575
FLMQLETFIADHEVH	RTL5	166	Q5HYW3
LQQFFVVMEHCLKHG	RUFY3	101	Q7L099
QHVLDMLFSAFEKHQ	GTF2F2	181	P13984
LEAFHFDHKTLEEQM	UTP20	1681	O75691
VVVRFFEQHLHSDKM	TMEM200A	111	Q86VY9
HMEIPHFFCEINQVV	OR7A10	171	O76100
QQFFVVMEHCLKHGL	RUFY1	146	Q96T51
VNNKMVHFDLLHEDV	HUS1	256	O60921
FLMPHVFQSHREFKE	SRCAP	791	Q6ZRS2
KPFSENEARHFMHQI	PLK4	106	O00444
TREDLHMDFKCVVHN	IL1R2	316	P27930
VVVEKDHFMDDFFHQ	STX2	21	P32856
LHHFIEVFNVMAVRS	LINC02915	166	Q8N8G6
AECFENMLERIHFHI	USP53	121	Q70EK8
VNKLFEFMHETHDGV	XPO1	566	O14980
HRFHKIFQMDEGLNH	USP4	541	Q13107
FIFADHTNMIHVENV	NIBAN1	526	Q9BZQ8
CEMVFNKKRHIQQHF	ZNF592	866	Q92610
DRFHEMHVALAQKDQ	TRAF7	296	Q6Q0C0
EFMTRHQVHEKEEFK	NF1	1571	P21359
HAFMQAHFKQREADE	SCN8A	1016	Q9UQD0
DFEEDNAAKVHLMVH	DHX38	396	Q92620
NRVKDMFSFEIPEHH	PAK1IP1	246	Q9NWT1
FFSERADLFMHQKIH	ZNF664	11	Q8N3J9
HVKFFCFQVLEHQVK	XPOT	51	O43592
RAHLEQVDKAVFHMQ	UNK	751	Q9C0B0
NEMLVTVAHFHKEVF	USP7	986	Q93009
HDRAAFAMVTHVKQE	TRRAP	2531	Q9Y4A5
HKFDMIQGLAEHNEL	TGFB3	106	P10600
QEACLRFMVVHFHEV	KLHL42	146	Q9P2K6
RFMVVHFHEVLCKPQ	KLHL42	151	Q9P2K6
DVFVHQSKLHMEGFR	LIN28A	71	Q9H9Z2