Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Visual acuity no light perception	DHX38 APC	2.13e-05	2	24	2	HP:0030553
Domain	ARM-type_fold	GBF1 PSME4 MROH7 APC TAF2 ARID1A PPP4R4	3.56e-05	339	51	7	IPR016024
Domain	UBA	VPS13D UBQLN3 RSC1A1	7.39e-05	30	51	3	SM00165
Domain	UBA	VPS13D UBQLN3 RSC1A1	2.35e-04	44	51	3	IPR015940
Domain	UBA	VPS13D UBQLN3 RSC1A1	2.86e-04	47	51	3	PS50030
Domain	-	PSME4 MROH7 APC ARID1A PPP4R4	3.41e-04	222	51	5	1.25.10.10
Domain	ARM-like	PSME4 MROH7 APC ARID1A PPP4R4	8.30e-04	270	51	5	IPR011989
Domain	HEAT_REPEAT	PSME4 MROH7 PPP4R4	9.23e-04	70	51	3	PS50077
Domain	DUF1605	DHX38 DHX35	9.68e-04	17	51	2	IPR011709
Domain	OB_NTP_bind	DHX38 DHX35	9.68e-04	17	51	2	PF07717
Domain	HA2	DHX38 DHX35	1.09e-03	18	51	2	SM00847
Domain	HA2	DHX38 DHX35	1.09e-03	18	51	2	PF04408
Domain	Helicase-assoc_dom	DHX38 DHX35	1.09e-03	18	51	2	IPR007502
Domain	DNA/RNA_helicase_DEAH_CS	DHX38 DHX35	4.11e-03	35	51	2	IPR002464
Domain	UBA	VPS13D UBQLN3	4.34e-03	36	51	2	PF00627
Domain	BROMODOMAIN_1	BRD4 SP110	4.58e-03	37	51	2	PS00633
Domain	DEAH_ATP_HELICASE	DHX38 DHX35	4.83e-03	38	51	2	PS00690
Domain	BROMODOMAIN_2	BRD4 SP110	5.60e-03	41	51	2	PS50014
Domain	BROMO	BRD4 SP110	5.87e-03	42	51	2	SM00297
Domain	Bromodomain	BRD4 SP110	5.87e-03	42	51	2	IPR001487
Domain	-	BRD4 SP110	5.87e-03	42	51	2	1.20.920.10
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TFEB ATXN2L VPS13D GBF1 PRRC2C BRD4 APC MAPK4 CDC25B PPP4R4	5.07e-07	861	52	10	36931259
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ATXN2L GBF1 PRRC2C RBMS2 APC SECISBP2 DHX35 TAF2 PRPF8	1.16e-06	724	52	9	36232890
Pubmed	ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription.	BRD4 ARID1A	2.19e-06	2	52	2	35715442
Pubmed	ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription.	APC ARID1A	2.19e-06	2	52	2	33084574
Pubmed	Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer.	NR4A2 APC	2.19e-06	2	52	2	16293616
Pubmed	MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB.	TFEB MAP4K3	2.19e-06	2	52	2	29507340
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PIKFYVE TFEB ATXN2L PRRC2C DHX38 APC SECISBP2 ARID1A	2.49e-06	588	52	8	38580884
Pubmed	ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response.	BRD4 ARID1A	6.57e-06	3	52	2	31913353
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	GBF1 PRRC2C MROH7 CRYBG1 PRPF8	1.31e-05	202	52	5	33005030
Pubmed	Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia.	TOX NR4A2	1.31e-05	4	52	2	37961948
Pubmed	Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.	MEAF6 BRD4	1.31e-05	4	52	2	35716662
Pubmed	Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.	NR4A2 APC	1.31e-05	4	52	2	19549529
Pubmed	Oncogenic Truncations of ASXL1 Enhance a Motif for BRD4 ET-Domain Binding.	ASXL3 BRD4	1.31e-05	4	52	2	34536441
Pubmed	Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival.	APC ARID1A	1.31e-05	4	52	2	26279473
Pubmed	An MST4-pβ-CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis.	STK26 APC	3.28e-05	6	52	2	34240584
Pubmed	Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children.	ATXN2L ZMIZ1	4.58e-05	7	52	2	20473688
Pubmed	A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer.	RBL1 APC	6.10e-05	8	52	2	25069779
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	GBF1 USHBP1 RBMS2 NR4A2 APC TAF2 NAIF1	7.17e-05	689	52	7	36543142
Pubmed	The protein interaction landscape of the human CMGC kinase group.	TFEB RBL1 RBMS2 STK26 APC MAPK4 PRPF8	7.57e-05	695	52	7	23602568
Pubmed	ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer.	ASXL3 BRD4	9.79e-05	10	52	2	32669118
Pubmed	The regulation and deregulation of Wnt signaling by PARK genes in health and disease.	NR4A2 APC	9.79e-05	10	52	2	24115276
Pubmed	Reprogramming tumour-associated macrophages to outcompete cancer cells.	PIKFYVE TFEB	1.20e-04	11	52	2	37380769
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	BRD4 APC ARID1A	1.29e-04	65	52	3	27453043
Pubmed	Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.	SYNE1 RERE ZMIZ1	1.29e-04	65	52	3	23453885
Pubmed	Common variants at five new loci associated with early-onset inflammatory bowel disease.	ATXN2L ZMIZ1	1.43e-04	12	52	2	19915574
Pubmed	SECISBP2L-Mediated Selenoprotein Synthesis Is Essential for Autonomous Regulation of Oligodendrocyte Differentiation.	APC SECISBP2	1.43e-04	12	52	2	35760530
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	MEAF6 TFEB VPS13D MAP4K3 RERE ARID1A	1.45e-04	536	52	6	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	MEAF6 TFEB VPS13D MAP4K3 RERE ARID1A	1.48e-04	538	52	6	10512203
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	BRD4 APC ARID1A	1.68e-04	71	52	3	28319113
Pubmed	Interaction network of human early embryonic transcription factors.	MEAF6 ASXL3 RERE ZMIZ1 ARID1A	1.79e-04	351	52	5	38297188
Pubmed	The Cdc25 genes map to mouse chromosomes 2, 9, and 18.	APC CDC25B	1.97e-04	14	52	2	8854867
Pubmed	Agrin has a pathological role in the progression of oral cancer.	VPS13D SYNE1 ZMIZ1 PRPF8	2.19e-04	197	52	4	29872149
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MEAF6 RBL1 BRD4 TAF2 RERE LONRF3 ARID1A SP110	2.36e-04	1116	52	8	31753913
Pubmed	Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.	DHX38 DHX35 PRPF8	2.39e-04	80	52	3	11991638
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	SYNE1 STK26 DHX38 APC DHX35 ARID1A CDC25B PRPF8	2.97e-04	1155	52	8	20360068
Pubmed	Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.	SYNE1 ZMIZ1	3.69e-04	19	52	2	18711365
Pubmed	Lost in transcription: molecular mechanisms that control HIV latency.	BRD4 TAF2	3.69e-04	19	52	2	23518577
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PSME4 RBL1 PRRC2C DHX38 APC CDC25B	4.08e-04	650	52	6	38777146
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	SYNE1 APC	4.09e-04	20	52	2	21689717
Pubmed	PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.	DHX38 PPP4R4	4.09e-04	20	52	2	18715871
Pubmed	Affinity purification strategies for proteomic analysis of transcription factor complexes.	TAF2 ARID1A PRPF8	4.21e-04	97	52	3	23937658
Pubmed	Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity.	NR4A2 ARID1A	4.52e-04	21	52	2	34011608
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	ATXN2L TOX PRRC2C BRD4 ARID1A PRPF8	4.61e-04	665	52	6	30457570
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	PRRC2C STK26 DHX38 APC	4.76e-04	242	52	4	34011540
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	GBF1 USHBP1 MROH7 SECISBP2 KLF17 DHX35 LONRF3 SLC5A2	4.81e-04	1242	52	8	30973865
Pubmed	PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA.	PRRC2C APC	4.97e-04	22	52	2	38507412
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ATXN2L DHX38 APC DHX35 ARID1A	5.05e-04	440	52	5	34244565
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	MEAF6 ATXN2L PRRC2C RBMS2 BRD4 ARID1A PRPF8	5.22e-04	954	52	7	36373674
Pubmed	An integrated workflow for charting the human interaction proteome: insights into the PP2A system.	ATXN2L STK26 PPP4R4	5.31e-04	105	52	3	19156129
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	ATXN2L PRRC2C APC PRPF8	5.88e-04	256	52	4	33397691
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	ATXN2L PRRC2C SYNE1 RBMS2	6.06e-04	258	52	4	37794589
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	MEAF6 TFEB BRD4 DHX38 ARID1A PRPF8 SP110 NAIF1	6.31e-04	1294	52	8	30804502
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	PIKFYVE TOX BRD4 NR4A2 KLF17 ARID1A	6.45e-04	709	52	6	22988430
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	PRRC2C BRD4 CRYBG1 TAF2 ARID1A	6.73e-04	469	52	5	27634302
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	MAP4K3 BRD4 APC MAPK4 ARID1A CDC25B	7.50e-04	730	52	6	34857952
Pubmed	Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.	BRD4 ARID1A	7.51e-04	27	52	2	29374058
Pubmed	Novel genes differentially expressed in cortical regions during late neurogenesis.	TOX NR4A2	8.08e-04	28	52	2	17614941
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PIKFYVE VPS13D GBF1 DHX38 PPP4R4	8.42e-04	493	52	5	15368895
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	ATXN2L ARID1A	8.67e-04	29	52	2	36800290
Pubmed	Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis.	TFEB CDC25B	9.29e-04	30	52	2	27179789
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	BRD4 DHX38 DHX35 PRPF8	1.06e-03	300	52	4	28561026
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	MEAF6 BRD4 ARID1A	1.08e-03	134	52	3	25452129
Pubmed	Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.	TFEB ARID1A PRPF8	1.10e-03	135	52	3	31077711
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	GBF1 PSME4 RBL1 PPP4R4	1.11e-03	304	52	4	32235678
Pubmed	Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.	RBL1 EXTL3 ZMIZ1	1.12e-03	136	52	3	25429064
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	BRD4 TAF2	1.12e-03	33	52	2	19336002
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	TFEB NR4A2	1.19e-03	34	52	2	25915474
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ATXN2L DPP6 MAP4K3 PRRC2C SYNE1 STK26 APC ARID1A	1.21e-03	1431	52	8	37142655
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE TFEB GBF1 PSME4 BRD4 EXTL3 ARID1A	1.23e-03	1105	52	7	35748872
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ATXN2L PRRC2C SYNE1 RBMS2 DHX38 PRPF8	1.26e-03	807	52	6	22681889
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ATXN2L PRRC2C BRD4 TAF2 ARID1A	1.36e-03	549	52	5	38280479
Pubmed	Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala.	ASXL3 APC	1.49e-03	38	52	2	38086370
Pubmed	A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex.	APC ARID1A	1.49e-03	38	52	2	32541003
GeneFamily	DEAH-box helicases	DHX38 DHX35	3.15e-04	16	30	2	500
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	MEAF6 PIKFYVE ATXN2L TOX SYNE1 SH2D3C NR4A2 SECISBP2 CRYBG1 ARID1A PRPF8 SP110	2.73e-05	1492	52	12	M40023
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	GBF1 PRRC2C ARID1A CDC25B PRPF8	2.89e-05	180	52	5	M8239
Coexpression	GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_UP	PSME4 RBMS2 CRYBG1 LONRF3 RSC1A1	3.93e-05	192	52	5	M8272
Coexpression	GSE31082_DN_VS_CD4_SP_THYMOCYTE_DN	MAP4K3 NR4A2 RERE EXTL3 SP110	4.78e-05	200	52	5	M5059
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOX PRRC2C STK26 NR4A2	6.03e-05	182	52	4	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	facs-Kidney-nan-24m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOX STK26 NR4A2 SP110	6.03e-05	182	52	4	e5f62ce9b9e0d28627617f7cbc81026f8442e402
ToppCell	facs-Kidney-nan-24m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOX STK26 NR4A2 SP110	6.03e-05	182	52	4	0e16824c721d8b7d527157cb65feec909f6b974c
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOX PRRC2C STK26 NR4A2	6.03e-05	182	52	4	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PIKFYVE TFEB TOX MAP4K3	6.16e-05	183	52	4	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	RBL1 RERE EXTL3 ARID1A	6.56e-05	186	52	4	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	RBL1 RERE EXTL3 ARID1A	6.56e-05	186	52	4	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIKFYVE TOX MAP4K3 RERE	7.12e-05	190	52	4	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	BAL-Control-Lymphocyte-B-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PIKFYVE LINS1 TOX NR4A2	7.12e-05	190	52	4	da7341a8a423e5fe4d8e733d8e50c10a3318ac1c
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PIKFYVE LINS1 TOX NR4A2	7.12e-05	190	52	4	682418a7a2096743112eae3790d40e7e600612c0
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	TOX EXTL3 MAPK4 TENM2	7.12e-05	190	52	4	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PIKFYVE LINS1 TOX NR4A2	7.12e-05	190	52	4	42312f7d79fe889397d32910b625793e2535cc26
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	PRRC2C NR4A2 CRYBG1 SP110	7.56e-05	193	52	4	7256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	DPP6 TOX MAP4K3 RERE	8.03e-05	196	52	4	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	DPP6 TOX MAP4K3 RERE	8.35e-05	198	52	4	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TOX SYNE1 STK26 PPP4R4	8.68e-05	200	52	4	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	MS-IIF\|MS / Disease, condition lineage and cell class	RBL1 NR4A2 DHX35 ALAS2	8.68e-05	200	52	4	221f59edcfc18baece13184c2552d26022228146
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TOX SYNE1 STK26 PPP4R4	8.68e-05	200	52	4	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 MROH7 APC PPP4R4	8.68e-05	200	52	4	d0812817ef99608994193787a62d39adeb2070ca
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 MROH7 APC PPP4R4	8.68e-05	200	52	4	cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCell	(22)_B_cell_memory\|World / shred on Cell_type and subtype	PIKFYVE TFEB NR4A2 SP110	9.19e-05	203	52	4	94ac418c9bfef1ce2e000a9c4117485651dfe85a
Drug	Calycanthine [595-05-1]; Down 200; 11.6uM; PC3; HT_HG-U133A	VPS13D ADGRG2 NR4A2 APC PPP4R4 SLC5A2	5.36e-06	195	52	6	5744_DN
Drug	Atractyloside potassium salt [102130-43-8]; Up 200; 5uM; MCF7; HT_HG-U133A	ATXN2L LINS1 NR4A2 RERE EXTL3 PPP4R4	5.52e-06	196	52	6	3435_UP
Drug	Methantheline bromide [53-46-3]; Down 200; 9.6uM; PC3; HT_HG-U133A	TFEB LINS1 VPS13D GBF1 BRD4 NR4A2	5.68e-06	197	52	6	5780_DN
Drug	Capsaicin [404-86-4]; Down 200; 13uM; MCF7; HT_HG-U133A	ATXN2L NR4A2 APC DHX35 RERE EXTL3	5.68e-06	197	52	6	3372_DN
Drug	2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A_EA	LINS1 EPS8L2 NR4A2 APC SECISBP2 ARID1A	5.85e-06	198	52	6	1020_DN
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Up 200; 11.8uM; HL60; HT_HG-U133A	EPS8L2 APC RERE ARID1A SP110 SLC5A2	5.85e-06	198	52	6	2197_UP
Drug	2-Aminobenzenesulfonamide [3306-62-5]; Down 200; 23.2uM; MCF7; HT_HG-U133A	VPS13D PSME4 APC EXTL3 ARID1A	7.63e-05	192	52	5	3400_DN
Drug	Rilmenidine hemifumarate [54187-04-1]; Down 200; 8.4uM; PC3; HT_HG-U133A	NR4A2 APC RERE EXTL3 SP110	7.82e-05	193	52	5	5107_DN
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; PC3; HT_HG-U133A	TFEB ATXN2L CEP83 APC CRYBG1	8.01e-05	194	52	5	3807_DN
Drug	Racecadotril [81110-73-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	LINS1 VPS13D TOX NR4A2 SLC5A2	8.01e-05	194	52	5	5755_DN
Drug	Dinoprost trometamol [38362-01-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	ATXN2L ADGRG2 NR4A2 APC PPP4R4	8.01e-05	194	52	5	3308_UP
Drug	ICI 182,780; Down 200; 1uM; HL60; HT_HG-U133A	ATXN2L PSME4 BRD4 NR4A2 APC	8.01e-05	194	52	5	6165_DN
Drug	3-Acetamidocoumarin [779-30-6]; Up 200; 19.6uM; MCF7; HT_HG-U133A	ATXN2L VPS13D DHX35 RERE PPP4R4	8.21e-05	195	52	5	7361_UP
Drug	ICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A	TFEB ATXN2L APC EXTL3 SP110	8.41e-05	196	52	5	5926_UP
Drug	Hesperetin [520-33-2]; Down 200; 13.2uM; MCF7; HT_HG-U133A	RBL1 RBMS2 BRD4 DHX35 EXTL3	8.41e-05	196	52	5	1531_DN
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	ATXN2L LINS1 VPS13D RBL1 SP110	8.41e-05	196	52	5	6954_DN
Drug	Chlorpropamide [94-20-2]; Up 200; 14.4uM; MCF7; HT_HG-U133A	ATXN2L ADGRG2 NR4A2 LONRF3 PPP4R4	8.41e-05	196	52	5	3210_UP
Drug	Ribostamycin sulfate salt [53797-35-6]; Down 200; 7.2uM; MCF7; HT_HG-U133A	ATXN2L RBL1 BRD4 NR4A2 ARID1A	8.61e-05	197	52	5	3444_DN
Drug	Ajmalicine hydrochloride [4373-34-6]; Down 200; 10.2uM; PC3; HT_HG-U133A	VPS13D ADGRG2 BRD4 DHX38 SP110	8.61e-05	197	52	5	6360_DN
Drug	Amrinone [60719-84-8]; Down 200; 21.4uM; HL60; HT_HG-U133A	ATXN2L VPS13D RERE SP110 PPP4R4	8.82e-05	198	52	5	2724_DN
Drug	Harmane hydrochloride [21655-84-5]; Down 200; 18.2uM; PC3; HT_HG-U133A	ATXN2L SYNE1 NR4A2 APC DHX35	8.82e-05	198	52	5	4584_DN
Drug	Mebendazole [31431-39-7]; Down 200; 13.6uM; PC3; HT_HG-U133A	TOX SYNE1 APC EXTL3 LONRF3	8.82e-05	198	52	5	7370_DN
Drug	Adrenosterone [382-45-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A	PSME4 RBL1 BRD4 APC SP110	8.82e-05	198	52	5	6486_DN
Drug	SC-560; Down 200; 10uM; PC3; HT_HG-U133A	VPS13D APC SECISBP2 EXTL3 SLC5A2	8.82e-05	198	52	5	6865_DN
Drug	Practolol [6673-35-4]; Down 200; 15uM; MCF7; HT_HG-U133A	ADGRG2 APC EXTL3 LONRF3 SP110	9.03e-05	199	52	5	5664_DN
Drug	rosiglitazone; Down 200; 10uM; HL60; HT_HG-U133A	TFEB ATXN2L APC EXTL3 SLC5A2	9.03e-05	199	52	5	2693_DN
Drug	Merbromin [129-16-8]; Down 200; 5uM; PC3; HT_HG-U133A	LINS1 SYNE1 CEP83 SECISBP2 DHX35	9.03e-05	199	52	5	7398_DN
Drug	Ciprofibrate [52214-84-3]; Down 200; 13.8uM; PC3; HT_HG-U133A	NR4A2 APC ARID1A PPP4R4 SLC5A2	9.03e-05	199	52	5	5740_DN
Drug	Amrinone [60719-84-8]; Down 200; 21.4uM; MCF7; HT_HG-U133A	ATXN2L BRD4 NR4A2 APC SP110	9.25e-05	200	52	5	3465_DN
Drug	1,3,4-thiadiazole	RBL1 SYNE1	1.07e-04	7	52	2	CID000119391
Disease	Intellectual Disability	LINS1 SYNE1 BRD4 NR4A2 APC TAF2 ZMIZ1	1.14e-05	447	51	7	C3714756
Disease	Colorectal Neoplasms	SYNE1 NR4A2 APC ZMIZ1 ARID1A	1.16e-04	277	51	5	C0009404
Disease	unipolar depression, bipolar disorder	SYNE1 ASXL3 RERE TENM2	1.55e-04	156	51	4	EFO_0003761, MONDO_0004985
Disease	T-Cell Lymphoma	ASXL3 ARID1A	3.46e-04	16	51	2	C0079772
Disease	Nasopharyngeal carcinoma	SYNE1 ARID1A	6.62e-04	22	51	2	C2931822
Disease	attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia	SYNE1 RERE ZMIZ1	7.19e-04	101	51	3	EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Disease	forced expiratory volume, response to bronchodilator	PIKFYVE DPP6 SYNE1 MS4A14 PPP4R4	1.01e-03	445	51	5	EFO_0004314, GO_0097366
Disease	response to angiotensin receptor blocker	MAPK4 TENM2	1.24e-03	30	51	2	EFO_0010735
Disease	prostate cancer (implicated_via_orthology)	APC PRPF8	1.49e-03	33	51	2	DOID:10283 (implicated_via_orthology)
Disease	cannabis dependence	GBF1 TOX TENM2	1.66e-03	135	51	3	EFO_0007191
Disease	endometrial cancer (is_marker_for)	APC CDC25B	1.68e-03	35	51	2	DOID:1380 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LPNQPLSPEMHIMEA	USHBP1	281	Q8N6Y0
EAPSPLMIHSPQMSQ	BRD4	1061	O60885
LPSSLMNNLPAHDME	ADGRG2	491	Q8IZP9
PSMELPFPPHMQEEQ	CEP83	656	Q9Y592
PHQLRLANMLSPNMP	ASXL3	1981	Q9C0F0
SDQHQPASAPPMMQA	ATXN2L	756	Q8WWM7
QPHPDMAQVPMLNLL	MROH7	36	Q68CQ1
DHPISLQPASMMGPL	RBMS2	326	Q15434
LHMQNPPFEPTSVDM	ARID1A	2216	O14497
ELAELQPPMFDLHPM	MAP4K3	206	Q8IVH8
PALMPPDHHVAVDML	LINS1	321	Q8NG48
LPPETPVDMMAQHAD	NAIF1	196	Q69YI7
NPMDRLTAEMGLQHP	MAPK4	296	P31152
LSLNPETLNRMHPMA	FAM205A	261	Q6ZU69
KTNAHMPVPMENVPD	KIAA0408	496	Q6ZU52
PSPMDPHMAEQTFEQ	CDC25B	116	P30305
PPSFPGNKDELMQHM	EPS8L2	576	Q9H6S3
LRLAPSPHHSPQMME	ALAS2	516	P22557
EFAMPPTLMQNPSFH	PIKFYVE	876	Q9Y2I7
HFMSPPPAQSMVQAL	DHX35	446	Q9H5Z1
HAMSEPNFMEIPPQV	EXTL3	321	O43909
PSHAMPPQDIPSQDM	MS4A14	391	Q96JA4
MAMHNKAAPPQIPDT	MEAF6	1	Q9HAF1
MPMEPQGQKPLASAH	GBF1	1726	Q92538
PSMAQMLPPQDAHDL	KLF17	206	Q5JT82
PEMSPALHLMQNLDT	CRYBG1	761	Q9Y4K1
LNGPTHDLEMMPPDD	DPP6	361	P42658
HAPTDQSPAMPMQNS	RSC1A1	86	Q92681
QQHSHLPPQSEEMMP	NR4A2	101	P43354
AAQPAASMVMFPHLP	HSFX1	376	Q9UBD0
PEMQMPNTLPLSSSH	TFEB	176	P19484
MHPPPPAAAMDFSQN	PPP4R4	1	Q6NUP7
PPDMAQNLLMDHLAI	SYNE1	4376	Q8NF91
LANQDHMMDAPPLSP	RBL1	951	P28749
ELAKGEPPNSDMHPM	STK26	211	Q9P289
EPPNSDMHPMRVLFL	STK26	216	Q9P289
QAPLEMSMHPAASAP	TAF2	1116	Q6P1X5
MQPHPQHLASMGFDP	PRRC2C	721	Q9Y520
MKTPHNPLDSSAPLM	SECISBP2	501	Q96T21
DSSGMPRHLLMPDNQ	TENM2	1641	Q9NT68
AIPPPMSAAHQLQAM	RERE	1506	Q9P2R6
MPHSPLGSMPEIRDN	SP110	241	Q9HB58
AHEPGMDQDKNPMPA	APC	426	P25054
MDQDKNPMPAPVEHQ	APC	431	P25054
HRASEMAGPPQMPND	PRPF8	1056	Q6P2Q9
ESAMEMNEPQAPAPS	SLC5A2	591	P31639
LLQFHFMDPPPEDNM	DHX38	906	Q92620
MNLSAHLNDPQPIEM	PSME4	1786	Q14997
SMPNLHPPMSPSALN	ZDHHC19	276	Q8WVZ1
SMDQIPDLHSPMSPI	SH2D3C	396	Q8N5H7
MNPHLTAMHPSLPRN	TOX	381	O94900
PLLMHLQAAMANPRA	UBQLN3	506	Q9H347
LSHPPDMPNNMAALE	ZMIZ1	921	Q9ULJ6
DMPNNMAALEKPLSH	ZMIZ1	926	Q9ULJ6
MPRSLPSHMEEAPNV	VPS13D	1721	Q5THJ4
HFGPMPEKDADPQMN	LONRF3	696	Q496Y0