Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear import signal receptor activity

TNPO1 IPO4

4.08e-0420302GO:0061608
GeneOntologyMolecularFunctionolfactory receptor activity

OR2J1 OR2J2 OR4S1 OR7A10 OR13F1

4.18e-04431305GO:0004984
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR2J1 ERBB2 OR2J2 OR4S1 GPR50 PTPRK OR7A10 OR13F1

6.63e-041353308GO:0004888
GeneOntologyMolecularFunctionnuclear localization sequence binding

TNPO1 IPO4

7.48e-0427302GO:0008139
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

TNPO1 IPO4

1.05e-0332302GO:0140142
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR2J1 OR2J2 OR4S1 GPR50 OR7A10 OR13F1

1.76e-03884306GO:0004930
DomainIMPORTIN_B_NT

TNPO1 IPO4

2.24e-0414302PS50166
DomainIBN_N

TNPO1 IPO4

2.59e-0415302PF03810
DomainIBN_N

TNPO1 IPO4

2.95e-0416302SM00913
DomainImportin-beta_N

TNPO1 IPO4

3.34e-0417302IPR001494
DomainOlfact_rcpt

OR2J1 OR2J2 OR4S1 OR7A10 OR13F1

3.71e-04393305IPR000725
Domain-

TNPO1 IPO4 ARMC3 TRRAP

4.18e-042223041.25.10.10
Domain7tm_1

OR2J1 OR2J2 OR4S1 GPR50 OR7A10 OR13F1

6.26e-04677306PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2J1 OR2J2 OR4S1 GPR50 OR7A10 OR13F1

6.66e-04685306PS00237
DomainG_PROTEIN_RECEP_F1_2

OR2J1 OR2J2 OR4S1 GPR50 OR7A10 OR13F1

6.97e-04691306PS50262
DomainGPCR_Rhodpsn

OR2J1 OR2J2 OR4S1 GPR50 OR7A10 OR13F1

7.02e-04692306IPR000276
DomainARM-like

TNPO1 IPO4 ARMC3 TRRAP

8.71e-04270304IPR011989
DomainARM-type_fold

TNPO1 IPO4 ARMC3 TRRAP

2.01e-03339304IPR016024
DomainHEAT

TNPO1 IPO4

2.69e-0348302PF02985
DomainHEAT

TNPO1 IPO4

3.90e-0358302IPR000357
DomainGPCR_Rhodpsn_7TM

OR2J2 OR4S1 GPR50 OR7A10 OR13F1

3.96e-03670305IPR017452
DomainHEAT_REPEAT

TNPO1 IPO4

5.63e-0370302PS50077
PathwayREACTOME_SENSORY_PERCEPTION

RDH10 OR2J1 OR2J2 OR4S1 OR7A10 OR13F1

2.50e-04636216M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2J1 OR2J2 OR4S1 OR7A10 OR13F1

3.04e-04417215M4072
Pubmed

Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} function.

ERBB2 PTPRK

2.16e-06330215899872
Pubmed

Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.

TNPO1 IPO4

7.18e-06530227528606
Pubmed

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1.

TNPO1 IPO4

1.08e-05630221965294
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

TNPO1 PRKCSH IPO4 TRIM24

1.67e-0517930436261009
Pubmed

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.

TNPO1 IPO4

2.01e-05830227114554
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

RDH10 ERBB2 PRKCSH TRRAP MAP4K3 MADD

2.97e-0571930635337019
Pubmed

Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.

OR2J1 OR2J2

5.58e-051330214506126
Pubmed

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.

TNPO1 DYSF

7.50e-051530226403541
Pubmed

The human olfactory receptor gene family.

OR2J1 OR2J2 OR4S1 OR7A10 OR13F1

9.24e-0554130514983052
Pubmed

The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia.

TNPO1 FBXO38 IPO4

9.39e-0510230337024974
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

FBXO38 TRIM24 TRRAP

1.37e-0411630330804394
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR2J1 OR2J2 OR7A10 OR13F1

2.01e-0434030411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR2J1 OR2J2 OR7A10 OR13F1

2.01e-0434030411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR2J1 OR2J2 OR7A10 OR13F1

2.08e-0434330432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR2J1 OR2J2 OR7A10 OR13F1

2.15e-0434630414611657
Pubmed

Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.

TNPO1 IPO4

2.31e-042630223181366
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

TNPO1 ERBB2 IPO4 TRIM24 MADD

2.84e-0468930536543142
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

RDH10 ERBB2 DYSF PCNX3 TRRAP MADD

3.13e-04110530635748872
Pubmed

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

ERBB2 PTPRK

7.59e-044730219167335
InteractionOR7A10 interactions

RNF123 OR7A10

4.80e-063262int:OR7A10
InteractionH4C3 interactions

RNF123 IPO4 TRIM24

3.59e-0550263int:H4C3
InteractionH4C2 interactions

RNF123 IPO4 TRIM24

4.53e-0554263int:H4C2
InteractionH4C12 interactions

RNF123 IPO4 TRIM24

4.53e-0554263int:H4C12
InteractionH4C13 interactions

RNF123 IPO4 TRIM24

5.61e-0558263int:H4C13
InteractionLRIG1 interactions

ERBB2 PRKCSH PTPRK

7.19e-0563263int:LRIG1
InteractionPLAAT3 interactions

RNF123 PRKCSH

8.74e-0511262int:PLAAT3
InteractionH4C6 interactions

RNF123 IPO4 TRIM24

9.44e-0569263int:H4C6
Cytoband11p11.2

OR4S1 MADD

1.36e-038330211p11.2
CytobandEnsembl 112 genes in cytogenetic band chr11p11

OR4S1 MADD

4.51e-03153302chr11p11
GeneFamilyArmadillo repeat containing|Importins

TNPO1 IPO4

3.24e-0418272596
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RDH10 ERBB2 MAP4K3 APCDD1L

7.17e-06193294d994b2f2707877288f88cab7cd6002ef91962c50
Diseasehepatocellular carcinoma, non-alcoholic steatohepatitis

PNPLA3 DYSF

5.99e-064302EFO_0000182, EFO_1001249
DiseaseAlzheimer disease, fasting blood glucose measurement

OR4S1 MADD

3.58e-059302EFO_0004465, MONDO_0004975
DiseaseOvarian Serous Adenocarcinoma

TRIM24 TRRAP

2.49e-0423302C1335177
DiseaseSquamous cell carcinoma of lung

TRIM24 MAP4K3

4.86e-0432302C0149782
Diseasehepatocellular carcinoma

C2 PNPLA3

7.99e-0441302EFO_0000182
Diseasebody composition measurement

PNPLA3 DYSF PRELP

9.82e-04193303EFO_0005106
Diseasealcohol use disorder (implicated_via_orthology)

ERBB2 MAP4K3 MADD

1.01e-03195303DOID:1574 (implicated_via_orthology)
Diseasebody mass index, fasting blood glucose measurement

OR4S1 MADD

1.24e-0351302EFO_0004340, EFO_0004465
Diseasepeak expiratory flow

TNPO1 ZC3H12B DYSF PTPRK

1.55e-03498304EFO_0009718
Diseasephospholipids:total lipids ratio

PNPLA3 BCL3 MADD

1.56e-03227303EFO_0020946
DiseaseMicrocephaly

TMX2 TRRAP

2.12e-0367302C0025958
DiseaseLupus Erythematosus, Systemic

C2 PCNX3

2.38e-0371302C0024141
Diseaseasparaginase hypersensitivity

PRKCSH ERMARD

2.79e-0377302EFO_0004881
Diseaseserum albumin measurement

TNPO1 DYSF MAP4K3 MADD

2.90e-03592304EFO_0004535
Diseasesusceptibility to shingles measurement

C2 OR2J1

3.08e-0381302EFO_0008401
Diseasefree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

PNPLA3 BCL3 MADD

3.55e-03303303EFO_0004612, EFO_0020945

Protein segments in the cluster

PeptideGeneStartEntry
LPQPPICTIDVYMIM

ERBB2

941

P04626
MPAAMLPYACVLVLL

APCDD1L

1

Q8NCL9
LPAPEMYVIDLMFHP

ARMC3

841

Q5W041
FPIPCPLRMFEMLVV

MAP4K3

716

Q8IVH8
LFFIPVMCMYLQPPS

OR2J1

251

Q9GZK6
AMIYPLEYMFPVIPL

MADD

341

Q8WXG6
LEYMFPVIPLLPTCM

MADD

346

Q8WXG6
EYLMELMTPAACPEP

PRKCSH

501

P14314
MGPLMVLFCLLFLYP

C2

1

P06681
PEYPPALIIFMFCAM

GPR50

21

Q13585
PFLLYMVLPPSLMVA

PCNX3

46

Q9H6A9
LLVLMPPMFMYIRPS

OR4S1

246

Q8NGB4
LPIRIMSYVMLPCTL

PNPLA3

346

Q9NST1
LFFIPVMCMYLQPPS

OR2J2

251

O76002
VPEIPCIPMLRHLYM

FBXO38

201

Q6PIJ6
LSMCYMLTYIPLLLP

FLVCR2

126

Q9UPI3
PEEIPPKYCSMMILL

ERMARD

196

Q5T6L9
FPLVNLPTPLYPMMC

BCL3

101

P20749
FMEVMLPREELYCPP

DYSF

1386

O75923
PKVQPYLPELMECML

IPO4

471

Q8TEX9
FMDMLPPDRCLPFLI

PTPRK

1206

Q15262
LLPMPMLLICISYAF

OR13F1

206

Q8NGS4
LMVLPLPFCTHMEIP

OR7A10

161

O76100
YLKPPIPLDLMMCFR

PRELP

361

P51888
LTDQPMICTPRLMYI

RDH10

281

Q8IZV5
IVFLMTCKPPLYMGP

TMX2

121

Q9Y320
CLPAPQRYLMLPAPM

TRIM24

81

O15164
PMLCPPEYMVCFLHR

RNF123

546

Q5XPI4
CMQGMIPYLPELIPH

TNPO1

436

Q92973
LMQPCYEPVMVRSVP

ZC3H12B

751

Q5HYM0
LPYLPMLMDPLVSAL

TRRAP

821

Q9Y4A5