Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainRibosomal_L3

RPL3 RPL3L

1.22e-0431202IPR000597
DomainRIBOSOMAL_L3

RPL3 RPL3L

1.22e-0431202PS00474
DomainRibosomal_L3

RPL3 RPL3L

1.22e-0431202PF00297
DomainRibosomal_L3_CS

RPL3 RPL3L

1.22e-0431202IPR019926
DomainTransl_B-barrel

GTPBP1 RPL3 RPL3L

6.76e-04271203IPR009000
DomainSpectrin_repeat

EVPL ACTN1 MCF2L

8.37e-04291203IPR002017
DomainHis_Pase_clade-2

MINPP1 PPIP5K1

1.12e-0381202IPR000560
DomainHis_Phos_2

MINPP1 PPIP5K1

1.12e-0381202PF00328
DomainSPEC

EVPL ACTN1 MCF2L

1.12e-03321203SM00150
DomainSpectrin/alpha-actinin

EVPL ACTN1 MCF2L

1.12e-03321203IPR018159
DomainAnk_2

ANKRD31 ANK2 CASKIN1 EHMT1 ANKRD34C ZDHHC13

2.67e-032151206PF12796
DomainPROTEIN_KINASE_ATP

CDC42BPA STYK1 SNRK MELK NEK3 MAP4K1 PRKCE FGFR1 MAP2K5

2.85e-034591209PS00107
DomainProtein_kinase_ATP_BS

CDC42BPA SNRK MELK NEK3 MAP4K1 PRKCE FGFR1 MAP2K5

3.12e-033791208IPR017441
DomainCNH

CDC42BPA MAP4K1

3.54e-03141202SM00036
DomainCNH

CDC42BPA MAP4K1

4.07e-03151202PF00780
DomainCNH

CDC42BPA MAP4K1

4.07e-03151202PS50219
DomainCNH_dom

CDC42BPA MAP4K1

4.07e-03151202IPR001180
DomainProt_kinase_dom

CDC42BPA STYK1 SNRK MELK NEK3 MAP4K1 PRKCE FGFR1 MAP2K5

4.32e-034891209IPR000719
DomainPROTEIN_KINASE_DOM

CDC42BPA STYK1 SNRK MELK NEK3 MAP4K1 PRKCE FGFR1 MAP2K5

4.56e-034931209PS50011
DomainATPase_P-typ_TM_dom

ATP2C1 ATP12A

4.63e-03161202IPR023298
Domain-

ATP2C1 ATP12A

4.63e-031612021.20.1110.10
DomainHelicase_C

DHX40 RAD54L2 ERCC6L2 DDX60L

5.03e-031071204PF00271
DomainHELICc

DHX40 RAD54L2 ERCC6L2 DDX60L

5.03e-031071204SM00490
DomainHelicase_C

DHX40 RAD54L2 ERCC6L2 DDX60L

5.20e-031081204IPR001650
DomainATPase_P-typ_cation-transptr_C

ATP2C1 ATP12A

5.23e-03171202IPR006068
DomainCation_ATPase_C

ATP2C1 ATP12A

5.23e-03171202PF00689
Domain-

ANKRD31 ANK2 CASKIN1 EHMT1 ANKRD34C ZDHHC13

5.36e-0324812061.25.40.20
DomainHELICASE_CTER

DHX40 RAD54L2 ERCC6L2 DDX60L

5.37e-031091204PS51194
DomainHELICASE_ATP_BIND_1

DHX40 RAD54L2 ERCC6L2 DDX60L

5.37e-031091204PS51192
DomainDEXDc

DHX40 RAD54L2 ERCC6L2 DDX60L

5.37e-031091204SM00487
DomainHelicase_ATP-bd

DHX40 RAD54L2 ERCC6L2 DDX60L

5.54e-031101204IPR014001
DomainANK

ANKRD31 ANK2 CASKIN1 EHMT1 ANKRD34C ZDHHC13

5.67e-032511206SM00248
DomainCation_ATPase_N

ATP2C1 ATP12A

5.86e-03181202PF00690
DomainCation_ATPase_N

ATP2C1 ATP12A

5.86e-03181202SM00831
DomainC1_1

CDC42BPA DGKQ PRKCE

5.88e-03571203PF00130
DomainANK_REPEAT

ANKRD31 ANK2 CASKIN1 EHMT1 ANKRD34C ZDHHC13

5.89e-032531206PS50088
DomainAnkyrin_rpt-contain_dom

ANKRD31 ANK2 CASKIN1 EHMT1 ANKRD34C ZDHHC13

6.00e-032541206IPR020683
DomainANK_REP_REGION

ANKRD31 ANK2 CASKIN1 EHMT1 ANKRD34C ZDHHC13

6.00e-032541206PS50297
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

HIVEP2 CDC42BPA CARMIL1 HDAC8 GRIK2 FRYL MSH5 ZSWIM6 ZNF236 ME2 UBLCP1 HIVEP3 DFFB ATP2C1 PRPF3 NAT10 EHMT1 AUTS2 PRKCE MCF2L ZDHHC13 EPB41 KDM4B

3.82e-0914891262328611215
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FLII HIVEP2 CDC42BPA INTS1 DGKQ FRYL ZNF236 PLEKHG5 HIVEP3 GRAMD2A CASKIN1 PAXIP1 EHMT1 FLCN AP1G2 FGFR1 HERC2 MCF2L

1.05e-0711051261835748872
Pubmed

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.

DYNC2I2 SORBS1 GTPBP1 ME2 LENG8 FBXO38 FGFR1 ZDHHC13

3.32e-06245126819521500
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CDC42BPA SNRK MELK PLEKHG5 ZNF512B CASKIN1 NAT10 EHMT1 PAN2 AUTS2 KDM4B

3.83e-065291261114621295
Pubmed

Human transcription factor protein interaction networks.

MRE11 RPL34 CDC42BPA DHX40 RPS5 BCL11A RAD54L2 GTPBP1 ZNF512B RHOA LENG8 NAT10 PAXIP1 EHMT1 AUTS2 HERC2 TAF1L SNTB2

4.16e-0614291261835140242
Pubmed

Interaction network of human early embryonic transcription factors.

HIVEP2 NAB1 BCL11A RAD54L2 ME2 ZNF512B PAXIP1 EHMT1 AUTS2

5.73e-06351126938297188
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

FLII DYNC2I2 RPS5 INTS1 ACTN1 RAD54L2 GTPBP1 PAXIP1 EHMT1 EPB41 SNTB2

9.55e-065831261129844126
Pubmed

A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region.

RPL3 RPL3L

1.30e-05212628921388
Pubmed

RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms.

PLEKHG5 RHOA

1.30e-052126227460990
Pubmed

RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.

RPL3 RPL3L

1.30e-052126237080962
Pubmed

Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.

HIVEP2 HIVEP3

1.30e-052126220404140
Pubmed

PTIP associates with Artemis to dictate DNA repair pathway choice.

DCLRE1C PAXIP1

1.30e-052126225512557
Pubmed

Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA.

DGKQ RHOA

1.30e-052126210066731
Pubmed

Expression of Muscle-Specific Ribosomal Protein L3-Like Impairs Myotube Growth.

RPL3 RPL3L

1.30e-052126226684695
Pubmed

Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes.

FERMT1 RHOA

1.30e-052126219762715
Pubmed

Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.

HIVEP2 HIVEP3

1.30e-05212622247438
Pubmed

Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest.

LRRTM3 CTNNA3

1.30e-052126221598020
Pubmed

Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.

RPL3 RPL3L

1.30e-052126236882085
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

HIVEP2 SKIDA1 BCL11A ZNF512B FBXO38 KLHL15 PAXIP1 EHMT1 AUTS2 ZNF292

1.38e-054951261027705803
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

MRE11 HIVEP2 DHX40 TAF1A NDUFA10 MELK FBXO38 PRPF3 KLHL15 PAN2 UMPS HERC2 RPL3L SNTB2

1.78e-0510051261419615732
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RPL34 ANK2 RPS5 SKIDA1 ACTN1 RAD54L2 PFKM UBLCP1 CEBPZ CFAP74 CEP295 FGFR1 ATP12A MCF2L RPL3 RPL3L ZNF292

1.85e-0514421261735575683
Pubmed

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.

RPL34 RPS5 INTS1 ACTN1 RHOA CEBPZ RPL3 RPL3L SNTB2

2.01e-05411126936652389
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

CDC42BPA DHX40 TEX15 FBXO38 NAT10 UMPS PPIP5K1

2.44e-05234126736243803
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MRE11 FLII RPL34 DHX40 RPS5 FERMT1 ACTN1 PFKM MELK PRPF3 CEBPZ NAT10 AP1G2 DDX60L HERC2 RPL3

3.21e-0513531261629467282
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

FLII TAF1A MSH5 ACTN1 ZNF236 PLEKHG5 ATP2C1 DENND10 CEBPZ AP1G2 FGFR1 MCF2L RPL3

3.29e-059251261328986522
Pubmed

A novel protein kinase C (PKCepsilon) is required for fMet-Leu-Phe-induced activation of NF-kappaB in human peripheral blood monocytes.

RHOA PRKCE

3.90e-053126215809302
Pubmed

Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2.

BBS2 BBS7

3.90e-053126212567324
Pubmed

Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder.

BBS2 BBS7

3.90e-053126211567139
Pubmed

Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma.

RHOA PRKCE

3.90e-053126217018591
Pubmed

Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database.

HIVEP3 ZNF292

3.90e-053126225849321
Pubmed

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.

RHOA MCF2L

3.90e-053126211889037
Pubmed

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.

PRKCE FGFR1

3.90e-053126223564461
Pubmed

Dental Anomalies in Ciliopathies: Lessons from Patients with BBS2, BBS7, and EVC2 Mutations.

BBS2 BBS7

3.90e-053126236672825
Pubmed

Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

MRE11 DCLRE1C

3.90e-053126215723659
Pubmed

Cross-link regulation of precursor N-cadherin and FGFR1 by GDNF increases U251MG cell viability.

GDNF FGFR1

3.90e-053126229750313
Pubmed

Dampening of death pathways by schnurri-2 is essential for T-cell development.

HIVEP2 HIVEP3

3.90e-053126221475200
Pubmed

Urokinase plasminogen activator inhibits HIV virion release from macrophage-differentiated chronically infected cells via activation of RhoA and PKCε.

RHOA PRKCE

3.90e-053126221858203
Pubmed

Molecular architecture of the Bardet-Biedl syndrome protein 2-7-9 subcomplex.

BBS2 BBS7

3.90e-053126231530639
Pubmed

Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production.

GDNF FGFR1

3.90e-053126221515689
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

DMXL2 CARMIL1 HDAC8 SKIDA1 FRYL MELK NEK3 LACC1 CRACDL SLC22A5 NAT10 MCF2L PRAMEF11 KDM4B DOP1B

4.55e-0512421261530973865
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

MRE11 NAB1 BCL11A ACTN1 RAD54L2 PFKM GTPBP1 RHOA LENG8 PRPF3 NFIL3 PAXIP1 EHMT1 ZNF292

4.89e-0511031261434189442
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

MRE11 ANK2 INTS1 PRPF3 CEBPZ NAT10 RPL3

6.19e-05271126732433965
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

FLII DMXL2 RPL34 ANK2 RPS5 CARMIL1 SORBS1 BCL11A ACTN1 PFKM GTPBP1 PLEKHG5 CRACDL CASKIN1 PRKCE RPL3

6.25e-0514311261637142655
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

STYK1 FBXO38 AREL1 MAP4K1 KLHL15 PRKCE FGFR1 MAP2K5

6.67e-05372126822939624
Pubmed

A human MAP kinase interactome.

HIVEP2 CDC42BPA EVPL SORBS1 ACTN1 LENG8 PRKCE HERC2 MAP2K5

7.33e-05486126920936779
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

DMXL2 CDC42BPA ADAM21 ATP2C1 MAP4K1 EHMT1 PRKCE MAP2K5 TAF1L RPL3 RPL3L

7.39e-057301261134857952
Pubmed

Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.

PLEKHG5 RHOA

7.78e-054126221543326
Pubmed

Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy.

BBS2 BBS7

7.78e-054126231690665
Pubmed

A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype.

PLEKHG5 RHOA

7.78e-054126216467373
Pubmed

The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.

PLEKHG5 RHOA

7.78e-054126220811643
Pubmed

Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility.

LRRC66 PAXIP1

7.78e-054126235768906
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

DHX40 RHOA GUCY1B2 BBS7 PAXIP1 EHMT1 FLCN CEP295 MCF2L SNTB2

1.15e-046381261031182584
Pubmed

Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.

DMXL2 RPL34 ANK2 ACTN1 PFKM NDUFA10 RHOA RPL3

1.16e-04403126830562941
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CDC42BPA INTS1 DFFB NEK3 MAP4K1 AUTS2 FLCN FGFR1 DDX60L MAP2K5 TAF1L SNTB2

1.22e-049101261236736316
Pubmed

The absence of BBSome function decreases synaptogenesis and causes ectopic synapse formation in the retina.

BBS2 BBS7

1.29e-045126232433491
Pubmed

MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.

MRE11 DCLRE1C

1.29e-045126228819025
Pubmed

DNA double strand break repair enzymes function at multiple steps in retroviral infection.

MRE11 DCLRE1C

1.29e-045126220003485
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MRE11 RPS5 INTS1 FRYL ACTN1 ME2 CEBPZ NAT10 HERC2 RPL3

1.39e-046531261022586326
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

MRE11 RPL34 ANK2 CARMIL1 PFKM ME2 ZNF512B LENG8 PRPF3 NAT10 RPL3 EPB41

1.55e-049341261233916271
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

MRE11 DHX40 RAD54L2 ZNF512B PRPF3 PAXIP1

1.65e-04222126637071664
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DMXL2 SNRK EHMT1 AUTS2 KDM4B DOP1B

1.77e-04225126612168954
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

DMXL2 HIVEP2 INTS1 ACTN1 GUCY1B2 PAXIP1 RPL3

1.80e-04322126726514267
Pubmed

Genome-wide association study of suicide attempts in mood disorder patients.

SORBS1 PRKCE

1.93e-046126221041247
Pubmed

Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.

DGKQ PRKCE

1.93e-046126222732145
Pubmed

Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.

DGKQ PRKCE

1.93e-046126215632189
Pubmed

BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes.

BBS2 BBS7

1.93e-046126222228099
Pubmed

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

RHOA MCF2L

1.93e-046126212006984
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

MRE11 FLII RPL34 RPS5 PFKM GTPBP1 PRDM7 NDUFA10 ME2 RHOA GUCY1B2 CEBPZ NAT10 EHMT1 RPL3

2.07e-0414251261530948266
Pubmed

Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.

MSH5 TEX15 SYCP2

2.13e-0432126327739607
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

MRE11 RAD54L2 PFKM FBXO38 NAT10 EHMT1 UMPS

2.17e-04332126732786267
Pubmed

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

MRE11 RPL34 PRPF3 NAT10 RPL3

2.17e-04149126525184681
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

DMXL2 RPS5 ACTN1 HIVEP3 EHMT1 ANKRD34C RPL3

2.21e-04333126732665550
Pubmed

A male germ-cell-specific ribosome controls male fertility.

RPL34 RPS5 RPL3 RPL3L

2.65e-0485126436517592
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

MRE11 RPL34 CDC42BPA RPS5 EVPL ZNF512B PRPF3 CEBPZ NAT10 EHMT1 RPL3

2.69e-048471261135850772
Pubmed

Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3.

ANK2 EPB41

2.70e-04712622968981
Pubmed

New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo.

MELK ZNF292

2.70e-04712629136115
Pubmed

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

MRE11 DCLRE1C

2.70e-047126219221393
Pubmed

Role of fibroblast growth factor receptor 2 in kidney mesenchyme.

GDNF FGFR1

2.70e-047126218670373
Pubmed

Protein interaction perturbation profiling at amino-acid resolution.

BBS2 BBS7

2.70e-047126229039417
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

MRE11 FERMT1 INTS1 PFKM GTPBP1 MELK PRPF3 NAT10 UMPS

2.81e-04582126920467437
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

DMXL2 ANK2 SORBS1 GTPBP1 CASKIN1 PRKCE SNTB2

2.83e-04347126717114649
Pubmed

Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.

BBS2 PRPF3 BBS7 C2

2.90e-0487126420801516
Pubmed

The molecular mechanics of eukaryotic translation.

RPL34 RPS5 RPL3 RPL3L

2.90e-0487126415189156
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

DMXL2 ANK2 GRIK2 SORBS1 CASKIN1 PRKCE

3.18e-04251126627507650
Pubmed

Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.

RPL34 RPS5 PFKM GTPBP1 NDUFA10 ME2 LENG8 PRPF3 UMPS RPL3

3.21e-047251261027025967
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DMXL2 RPL34 CDC42BPA ANK2 BBS2 PFKM ME2 ZNF512B CEBPZ BBS7 NAT10 EHMT1 HERC2 RPL3 SNTB2

3.26e-0414871261533957083
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

MRE11 CDC42BPA DHX40 INTS1 ACTN1 NDUFA10 RHOA LENG8 CEBPZ CRACDL EHMT1 HERC2 TAF1L EPB41 SNTB2

3.50e-0414971261531527615
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MRE11 FLII RPS5 INTS1 ACTN1 ZNF512B PRPF3 CEBPZ BBS7 NAT10 HERC2 RPL3

3.58e-0410241261224711643
Pubmed

Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

MRE11 DCLRE1C

3.59e-048126215456891
Pubmed

Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development.

GDNF FGFR1

3.59e-048126221128305
Pubmed

Dissection of epistasis in oligogenic Bardet-Biedl syndrome.

BBS2 BBS7

3.59e-048126216327777
Pubmed

RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity.

ACTN1 RHOA

3.59e-048126214581471
Pubmed

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PLEKHG5 RHOA ATP2C1 ZDHHC13

3.89e-0494126412761501
Pubmed

Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.

MSH5 TEX15 SYCP2

4.16e-0440126320378615
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

ANK2 DHX40 RHOA NAT10 AP1G2 HERC2 KDM4B

4.23e-04371126715747579
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

FLII BBS2 CASP10 ZNF512B RHOA ATP2C1 PRPF3 NAT10 EHMT1 SNTB2

4.36e-047541261035906200
Pubmed

SPARC is expressed by macroglia and microglia in the developing and mature nervous system.

MPZ ADAM21

4.61e-049126218366138
Pubmed

The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.

BBS2 BBS7

4.61e-049126220603001
Pubmed

Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation.

BBS2 BBS7

4.61e-049126222302990
Pubmed

Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.

BBS2 BBS7

4.61e-049126218762586
GeneFamilyBardet-Biedl syndrome associated|BBSome

BBS2 BBS7

5.45e-0488121122
GeneFamilyAnkyrin repeat domain containing

ANKRD31 ANK2 CASKIN1 EHMT1 ANKRD34C ZDHHC13

7.59e-04242816403
GeneFamilyL ribosomal proteins

RPL34 RPL3 RPL3L

1.55e-0351813729
CoexpressionGSE26156_DOUBLE_POSITIVE_VS_CD4_SINGLE_POSITIVE_THYMOCYTE_UP

RPL34 CDC42BPA SNRK BCL11A RGS1 PAN2 AUTS2 FGFR1 MCF2L

5.01e-071991259M8298
CoexpressionGSE22886_NAIVE_CD4_TCELL_VS_12H_ACT_TH2_UP

INTS1 SNRK PARP6 PAN2 AP1G2 MCF2L MAP2K5 RPL3

5.28e-061991258M4526
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

HIVEP2 CARMIL1 FERMT1 BCL11A GDNF AUTS2 FGFR1 HS3ST4

4.25e-08179125814fc8ccb6b215063d747643f47d780d2b237eb67
ToppCellpdx-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

HIVEP2 CARMIL1 FERMT1 BCL11A ZSWIM6 GDNF FGFR1 HS3ST4

4.83e-0818212587b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn|World / Primary Cells by Cluster

RPL34 ANK2 RPS5 SORBS1 BCL11A ZSWIM6 AUTS2 DOP1B

8.55e-0819612589401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells-ectodermal/neuroectodermal-like_cells|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

RPL34 ADAM21 RPS5 FERMT1 STYK1 EVPL RPL3

4.54e-071661257d7e49416426a62801ea1062d7aaf55ea622ae118
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DGKQ FRYL ACTN1 PAN2 HERC2 MCF2L

6.31e-0616112565fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

ANK2 SORBS1 LRRTM3 BCL11A CTNNA3 ANKRD34C

1.39e-0518512566baccb26f999145e51b91d94315bf8d4655bef31
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

ANK2 SORBS1 LRRTM3 BCL11A CTNNA3 RPL3L

1.57e-0518912565e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellHSPCs-Ery_prog.|HSPCs / Lineage and Cell class

RPS5 BCL11A MINPP1 NAT10 C2 RPL3

1.57e-05189125637d2c45debed1564a40a1085b8b310c50923b9e7
ToppCell15-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

RPL34 RPS5 FNDC1 CILP2 AUTS2 RPL3

1.88e-051951256414f60bc0f0d0ecb5137bcd617fae91f0c15038a
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SORBS1 LRRTM3 ACTN1 NFIL3 CTNNA3 CCDC144A

1.99e-051971256cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCellCOVID_vent-Lymphocytic-T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

MDFIC RPL34 HIVEP2 RPS5 RPL3 EPB41

1.99e-051971256ad702e440a74d54cfdcb8bb1c66bd8e0e71ab04e
ToppCellBrain_organoid-organoid_Velasco_nature-3_mon-Neuronal-Immature_CPNs|3_mon / Sample Type, Dataset, Time_group, and Cell type.

RPL34 RPS5 BCL11A AUTS2 RPL3 DOP1B

2.04e-05198125632d58379a89be19b6b1a494bf033416546771c19
ToppCellCOVID_vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

MDFIC RPL34 HIVEP2 RPS5 RPL3 EPB41

2.04e-05198125658f208b76cb0adcecdf632d92f92833a06f9bf71
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

RPL34 HIVEP2 BCL11A ZSWIM6 HIVEP3 DOP1B

2.16e-05200125684e4565d28a02700bf7f6730d1b3a58744ca0aea
DiseaseRNA polymerase II subunit A C-terminal domain phosphatase SSU72 measurement

NLRP12 DGKQ

1.70e-0521222EFO_0802029
Diseaseragulator complex protein LAMTOR3 measurement

NLRP12 RHOA

1.01e-0441222EFO_0801986
Diseasemental or behavioural disorder, attempted suicide

SORBS1 PRKCE

1.68e-0451222EFO_0000677, EFO_0004321
DiseaseEctodermal Dysplasia

DHX40 RHOA

2.52e-0461222C0013575
Diseaseubiquitin-like protein ISG15 measurement

NLRP12 C2

2.52e-0461222EFO_0021875
Disease1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 measurement

NLRP12 C2

3.51e-0471222EFO_0020108
DiseaseBurkitt Lymphoma

SALL3 RHOA AUTS2

4.46e-04361223C0006413
DiseaseAbnormality of the skeletal system

INTS1 ZNF292

4.67e-0481222C4021790
Diseasesialic acid-binding Ig-like lectin 12 measurement

NLRP12 UMPS

4.67e-0481222EFO_0802066
Diseaseacoustic neuroma (is_marker_for)

GDNF FGFR1

5.99e-0491222DOID:12689 (is_marker_for)
Diseasepulse pressure measurement

ANK2 CARMIL1 NAB1 FRYL MSH5 PFKM HIVEP3 FBXO38 AREL1 FNDC1 CILP2 CTNNA3 PRKCE MCF2L KDM4B

6.38e-04139212215EFO_0005763
Diseasesunburn

PRDM7 PRKCE FGFR1 HERC2

6.89e-04961224EFO_0003958
Diseasebody weight

MPZ LRRC66 MDFIC HIVEP2 BBS2 GRIK2 ZSWIM6 NFIL3 CTNNA3 AUTS2 PRKCE MAP2K5 RPL3 KDM4B

7.31e-04126112214EFO_0004338
Disease1,7-dimethylurate measurement

MDFIC GRIK2

7.47e-04101222EFO_0021512
DiseaseBardet-Biedl syndrome (implicated_via_orthology)

BBS2 BBS7

9.10e-04111222DOID:1935 (implicated_via_orthology)
Diseasesmoking status measurement

CDC42BPA SAMD8 SNRK GRIK2 PFKM ATP2C1 CRACDL CTNNA3 AUTS2 CEP295 FGFR1 MAP2K5 KDM4B

1.05e-03116012213EFO_0006527
Diseasemean arterial pressure

NAB1 BBS2 GDNF HIVEP3 AUTS2 PRKCE ATP12A KDM4B

1.13e-034991228EFO_0006340
DiseaseGlioblastoma Multiforme

STYK1 GRIK2 GDNF TAF1L

1.18e-031111224C1621958
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

HIVEP2 HIVEP3

1.28e-03131222DOID:0050787 (implicated_via_orthology)
Diseasehomostachydrine measurement

SLC22A5 HS3ST4

1.28e-03131222EFO_0021164
Diseasemonokine induced by gamma interferon measurement

BCL11A CTNNA3 ERCC6L2

1.31e-03521223EFO_0008236
DiseaseBardet-Biedl syndrome (is_implicated_in)

BBS2 BBS7

1.49e-03141222DOID:1935 (is_implicated_in)
DiseaseAlzheimer's disease (implicated_via_orthology)

HIVEP2 ANK2 HIVEP3

1.71e-03571223DOID:10652 (implicated_via_orthology)
DiseaseAlopecia, Male Pattern

RHOA ZDHHC13

1.72e-03151222C4083212
Diseasegamma-glutamylphenylalanine measurement

LRRTM3 CTNNA3

1.72e-03151222EFO_0021142
DiseaseAndrogenetic Alopecia

RHOA ZDHHC13

1.72e-03151222C0162311
DiseaseFemale pattern alopecia (disorder)

RHOA ZDHHC13

1.72e-03151222C0263477
Diseasepursuit maintenance gain measurement

CARMIL1 GRIK2 MINPP1 DDX60L

1.73e-031231224EFO_0008433
Diseasesystemic lupus erythematosus

CARMIL1 NAB1 DGKQ MSH5 UBLCP1 RGS1 CTNNA3 C2 RPL3 KDM4B

1.81e-0379912210MONDO_0007915
Diseasemosquito bite reaction size measurement

ACTN1 ZNF236 SLC22A5 AUTS2 C2

1.92e-032121225EFO_0008378
Diseasemethadone dose measurement

MPZ BCL11A TEX15

2.18e-03621223EFO_0007907
DiseaseBardet-Biedl syndrome 1 (disorder)

BBS2 BBS7

2.21e-03171222C2936862
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

KDM4B ZNF292

2.21e-03171222DOID:0060307 (is_implicated_in)
DiseaseBardet-Biedl syndrome

BBS2 BBS7

2.48e-03181222cv:C0752166
DiseasePseudopelade

RHOA ZDHHC13

2.77e-03191222C0086873
DiseaseAlopecia

RHOA ZDHHC13

2.77e-03191222C0002170
Diseasesynophrys measurement

ERCC6L2 AUTS2 HERC2

2.84e-03681223EFO_0007906
Diseasepolymyositis

NAB1 DGKQ

3.07e-03201222EFO_0003063
DiseaseHeadache, HbA1c measurement

PFKM FLACC1

3.38e-03211222EFO_0004541, HP_0002315
Diseasemean platelet volume

LRRC66 HIVEP2 CARMIL1 NAB1 FRYL SORBS1 ACTN1 ZNF512B SLC22A5 UMPS MCF2L

3.42e-03102012211EFO_0004584
Diseasenucleotide measurement

CARMIL1 UMPS PRKCE

3.47e-03731223EFO_0010513
Diseasecognitive function measurement, self reported educational attainment

DMXL2 CARMIL1 BCL11A MSH5 RHOA AUTS2

3.65e-033551226EFO_0004784, EFO_0008354
DiseaseAmphetamine-Related Disorders

GDNF HS3ST4 MAP2K5

3.75e-03751223C0236733
DiseaseAmphetamine Abuse

GDNF HS3ST4 MAP2K5

3.75e-03751223C0236807
DiseaseAmphetamine Addiction

GDNF HS3ST4 MAP2K5

3.75e-03751223C0236804
Diseasecoronary artery disease

ANKRD31 HIVEP2 CARMIL1 NAB1 RHOA FNDC1 PAN2 UMPS PRKCE C2 MCF2L KDM4B

3.97e-03119412212EFO_0001645
Diseasesphingomyelin 24:1 measurement

ME2 CCDC70

4.05e-03231222EFO_0010398
Diseasespermatogenic failure (is_implicated_in)

MSH5 KCNU1

4.05e-03231222DOID:0111910 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
ELKASQKPIRKHRNM

EPB41

196

P11171
ALMLKKRIVVYHPKI

DENND10P1

176

Q6NSW5
TSQKTMKLIPASRHR

BBS7

16

Q8IWZ6
MKLIPASRHRATQKV

BBS7

21

Q8IWZ6
RLAKPERGKMRVHKI

ACTN1

76

P12814
DLRSKKKLLRRHSMQ

ANKRD34C

506

P0C6C1
MRVKKLLVSRHLPVF

ADAM21

76

Q9UKJ8
AVKSIHRKRMPVKEV

GTPBP1

441

O00178
AKLLFTPQHKMLRLR

FERMT1

86

Q9BQL6
KKAILTAVHMIRKVP

AP1G2

156

O75843
HMLRKAKQKPRRAGT

DGKQ

911

P52824
ASSPSIRQKKLMHKL

CCDC70

31

Q6NSX1
RKHIPRKKRSALKDM

CCDC144CP

1156

Q8IYA2
MLQKPKSVKLRALRS

DFFB

1

O76075
RLMDPVKHIKGSSKQ

DMXL2

691

Q8TDJ6
KRAQKPSHMRRNIRK

RAD54L2

101

Q9Y4B4
SPRHKMKIIKSLQKN

ATP2C1

621

P98194
HSLLDDKMQKRRPKT

RGS1

31

Q08116
VDPKKRISMKNLLNH

MELK

246

Q14680
PLHIACKKNRIKVME

ANK2

401

Q01484
KMKVNKISLHSINRR

ANKRD31

471

Q8N7Z5
KVLSKQPSFRKLMEH

PAXIP1

1001

Q6ZW49
RKQRKTHTTFIPLML

PAN2

951

Q504Q3
ITKLGHQKKLMLAVR

CASKIN1

586

Q8WXD9
KLSVEHKQRPKVELM

FLII

746

Q13045
MSDKLKERKRTPVSH

HELT

1

A6NFD8
RKLSAPVSQKMHRKI

MDFIC

121

Q9P1T7
RKLPVFKSLRHMRQV

FLCN

341

Q8NFG4
KPVVSPKMKIHSARQ

FLACC1

56

Q96Q35
KIRLKPKVLLNHFML

INTS1

411

Q8N201
VGMASKPLHVRRLQK

NAB1

56

Q13506
KPKMVKVLLGHRVIQ

HERC2

3141

O95714
SILKAFMTKNPHKRL

PRKCE

636

Q02156
IMNRKPRHKNKDRLV

ATP12A

846

P54707
KLAQKVKMSTHARPI

C2

566

P06681
SRKKAQRHSKMKIIP

DOP1B

1696

Q9Y3R5
KRHDLAPTKRSRKKM

LENG8

481

Q96PV6
MSRRKQGKPQHLSKR

BCL11A

1

Q9H165
MQQLPRSTKLKKHPR

DYNC2I2

316

Q96EX3
VNMKKEHQLPLSRIK

DDX60L

1531

Q5H9U9
KQTRHRKLKVLEMPS

HMGN2P46

146

Q86SG4
SLKILHRDVKPSNML

MAP2K5

276

Q13163
HLVQKMKTTVKRGLV

PFKM

611

P08237
SALPHKLRIKAKAMQ

NFIL3

321

Q16649
KRKTMQPHLLTKEVT

EVPL

1006

Q92817
LSHLKNKDPKMSRVA

FRYL

341

O94915
HLGKRKKMPKALRQL

AUTS2

161

Q8WXX7
SKLKMEIKKSRRHPL

KDM4B

601

O94953
SSIKVIVPRHRKTLM

LACC1

101

Q8IV20
TIKRLKRSPDKQMAV

GDNF

71

P39905
RQHITVPSVKRMKKC

KCNU1

626

A8MYU2
HKLQVKPRNQRSSKM

CRACDL

226

Q6NV74
SSHRKKRMRQLQKKI

NAT10

66

Q9H0A0
HRMKSLIRSKAERPQ

LRRC66

311

Q68CR7
NSRKEAVLLAKMKHP

NEK3

46

P51956
RRIQKKGDPHEMKIT

NDUFA10

216

O95299
VAKTKPRHAMKRKRT

FBXO38

886

Q6PIJ6
AKKKIHPLQVMSEFR

CTNNA3

876

Q9UI47
HSMVNSKILLLKKPR

KLHL15

291

Q96M94
FTLKLRHKISPRMVA

BBS2

6

Q9BXC9
KDHMKGLRAPTLKRR

DCLRE1C

36

Q96SD1
QMAVHKLAKSIPLRR

FGFR1

411

P11362
LKPRHVKLLSTKMGL

FNDC1

41

Q4ZHG4
RQVHMKRPHSKVTLK

AREL1

451

O15033
HTKVKELARFKPMQR

MCF2L

846

O15068
LRFHRNLKKMTSPLE

ME2

66

P23368
SLCNHLKKLVPRMLK

CASP10

461

Q92851
TPKSKRKSIHSRMLR

CARMIL1

916

Q5VZK9
HRIKNPKARVTEVMK

ERCC6L2

286

Q5T890
LAKIPKRASMVHSLI

HDAC8

31

Q9BY41
RKHIPRKKRSALKDM

CCDC144A

1346

A2RUR9
RMSLKCQRRLKHKPQ

GRIK2

866

Q13002
SVQMIKKHKMARLLP

GRAMD2A

131

Q8IUY3
MKRKVVNTHKLRLSP

CEP295

1

Q9C0D2
KSPNRKEHLKVVVMS

DHX40

196

Q8IX18
ALMLKKRIVVYHPKI

DENND10

176

Q8TCE6
RVKGMKHRKTPSHTR

SLC22A5

526

O76082
MSRRKQAKPQHLKSD

SALL3

1

Q9BXA9
ADVKVHRARKTMPKS

EHMT1

196

Q9H9B1
KLFKVSVPHVLEMRK

CFAP74

1156

Q9C0B2
PKRIHSMAKDIKLIV

HS3ST4

271

Q9Y661
VVMQPKRKHFIKDIR

CEBPZ

776

Q03701
HRMPTLKANIRAVKR

PRPF3

276

O43395
RTILKIPSMSQRKKA

OR6C75

221

A6NL08
RSHIVKLPLSRLKFM

PARP6

426

Q2NL67
PKVLMRLSKTKKHVS

RPL34

61

P49207
VPLILKRMKLSHTKV

MSH5

316

O43196
SPHRLLARKNMVSTK

MAP4K1

586

Q92918
RNNGKKLMTVRIVKH

RPS5

81

P46782
HTRRELAKMKQEPVK

RHOA

126

P61586
KRLMLSVRKLQKIHI

SAMD8

66

Q96LT4
HRKKKRQSLKQMTPS

LRRTM3

461

Q86VH5
TQMRLLPLRQKKAHL

RPL3

166

P39023
TQMKLLPFRQKKAHI

RPL3L

166

Q92901
HQILGKKIKRMKRSV

TAF1A

426

Q15573
KLRKTQHEPVIKSRM

TAF1L

386

Q8IZX4
VKKRVKIHPNTVMVK

SLC35G2

11

Q8TBE7
HRKMRKTKPKRLQDS

GUCY1B2

111

O75343
ILIHAAVMTKPKVKR

PRDM7

471

Q9NQW5
LLKNIPRTTVHKRMD

SKIDA1

36

Q1XH10
LLRIKGRKMNMHKIP

MRE11

286

P49959
KPFTSKVKQMRLHRE

CDC42BPA

61

Q5VT25
KKPMSLSTQVVLRRK

SNRK

456

Q9NRH2
KTISPQMKTLKKRNH

CCDC54

211

Q8NEL0
VKAMRKKAPVILHTS

CILP2

551

Q8IUL8
LEHLQRRKIMKRPSS

STYK1

336

Q6J9G0
KLSDMLAKPHQRLTK

PLEKHG5

476

O94827
MAGIIKKQILKHLSR

UHRF1BP1L

1

A0JNW5
RNGHEAPMTKIKKLT

ZNF761

106

Q86XN6
QSKHMKQTLSLRKTP

ZDHHC13

561

Q8IUH4
KKQMHRKFRSGLIVP

MINPP1

396

Q9UNW1
MKLKRKRASSVLPEH

SPDYE4

91

A6NLX3
EENIHSRMKTVKLPK

SYCP2

1051

Q9BX26
KTMFKQIHKLNRDTP

SORBS1

396

Q9BX66
HVKQSSKERLAAMKP

ZNF292

591

O60281
IRCKKPSMLKKHIRT

HIVEP3

1761

Q5T1R4
IHPVASKLLRLMQKK

UMPS

236

P11172
MKKVRHLRHPKRILF

PRAMEF11

441

O60813
NVVTRKTLVGLKKHM

ZNF512B

516

Q96KM6
MFRTQKKELPHKNIT

ZSWIM6

606

Q9HCJ5
LKIRPFMKAHLNRDK

UBLCP1

266

Q8WVY7
HTELRKMRHQRKPAK

ZNF236

591

Q9UL36
KMRHQRKPAKVRVGK

ZNF236

596

Q9UL36
LANEAMKPSKLKRHL

ZBED9

766

Q6R2W3
DSLKRNHLTPKKVEM

TEX15

2376

Q9BXT5
IRCKKPSMLKKHIRT

HIVEP2

1806

P31629
HQNSTKDRKIIPLKM

SNTB2

236

Q13425
MAGIIKKQILKHLSR

UHRF1BP1

1

Q6BDS2
MVRPHLLKKKILGRV

PRO2829

1

Q9P1C3
AIIRHGDRTPKQKMK

PPIP5K1

396

Q6PFW1
KMTHSRLAALRVTKP

NLRP12

1041

P59046
QRRLSAMEKGKLHKP

MPZ

191

P25189