Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXNA3 PLXND1 PLXNA1 PLXNA2

8.93e-07121334GO:0017154
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH3 DNAH7 DNAH12 DYNC1H1

5.35e-06181334GO:0008569
GeneOntologyMolecularFunctionhistone H3K14 acetyltransferase activity

KAT6A JADE1 KAT6B

2.36e-0591333GO:0036408
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH3 DNAH7 DNAH12 DYNC1H1

3.40e-05281334GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH3 DNAH7 DNAH12 DYNC1H1

1.05e-04371334GO:0045505
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

KAT6A JADE1 KAT6B

1.24e-04151333GO:0010484
GeneOntologyBiologicalProcesspositive regulation of apoptotic cell clearance

C2 C4A C4B

1.43e-0581333GO:2000427
GeneOntologyBiologicalProcessregulation of apoptotic cell clearance

C2 C4A C4B

3.04e-05101333GO:2000425
GeneOntologyBiologicalProcessolfactory nerve formation

PLXNA3 PLXNA1

4.13e-0521332GO:0021628
GeneOntologyBiologicalProcesspeptidyl-tyrosine dephosphorylation

PTPN6 PTPN12 PTPRJ DUSP10

6.59e-05341334GO:0035335
GeneOntologyBiologicalProcessnegative regulation of platelet-derived growth factor receptor signaling pathway

PTPN12 PTPRJ LRP1

9.06e-05141333GO:0010642
GeneOntologyBiologicalProcesspositive regulation of axonogenesis

PLXNA3 DSCAM PLXND1 LRP1 PLXNA1 PLXNA2

9.68e-051141336GO:0050772
GeneOntologyCellularComponentsemaphorin receptor complex

PLXNA3 PLXND1 PLXNA1 PLXNA2

9.78e-07131304GO:0002116
GeneOntologyCellularComponentmicrotubule associated complex

DNAH3 FNTA DNAH7 KIFAP3 DNAH12 RP1 DYNC1H1 KLC3

7.62e-061611308GO:0005875
GeneOntologyCellularComponentinner dynein arm

DNAH3 DNAH7 DNAH12

2.73e-05101303GO:0036156
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

DNAH3 ARFGEF2 EVPL ACTN3 DNAH7 PPL EFHC2 KIFAP3 DNAH12 INF2 EHHADH RP1 PLS3 DYNC1H1 KLC3 DMTN

1.48e-0489913016GO:0099513
GeneOntologyCellularComponentaxoneme

DNAH3 ARFGEF2 DNAH7 EFHC2 KIFAP3 DNAH12 RP1

3.19e-042071307GO:0005930
GeneOntologyCellularComponentciliary plasm

DNAH3 ARFGEF2 DNAH7 EFHC2 KIFAP3 DNAH12 RP1

3.28e-042081307GO:0097014
GeneOntologyCellularComponentdynein complex

DNAH3 DNAH7 DNAH12 DYNC1H1

3.55e-04541304GO:0030286
GeneOntologyCellularComponentaxonemal dynein complex

DNAH3 DNAH7 DNAH12

4.89e-04251303GO:0005858
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

KAT6A KAT6B

7.90e-0471302GO:0070776
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

DNAH3 ARFGEF2 DNAH7 EFHC2 KIFAP3 DNAH12 RP1 DYNC1H1

8.40e-043171308GO:0032838
GeneOntologyCellularComponentsupramolecular fiber

DNAH3 ARFGEF2 EVPL ACTN3 DNAH7 PPL EFHC2 KIFAP3 DNAH12 INF2 EHHADH SCN5A RP1 PLS3 DYNC1H1 KLC3 DMTN

1.03e-03117913017GO:0099512
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

1.05e-0381302GO:0106139
GeneOntologyCellularComponentH3 histone acetyltransferase complex

KAT6A KAT6B

1.05e-0381302GO:0070775
GeneOntologyCellularComponentsupramolecular polymer

DNAH3 ARFGEF2 EVPL ACTN3 DNAH7 PPL EFHC2 KIFAP3 DNAH12 INF2 EHHADH SCN5A RP1 PLS3 DYNC1H1 KLC3 DMTN

1.11e-03118713017GO:0099081
GeneOntologyCellularComponentother organism part

C4A C4B

1.34e-0391302GO:0044217
GeneOntologyCellularComponentnuclear body

NRIP1 VRK1 HDAC5 RAPH1 POLE2 KAT6A BARD1 ZMYM2 JADE1 SMC5 TENM2 SERPINB13 HACE1 PLCB1

1.49e-0390313014GO:0016604
GeneOntologyCellularComponentmicrotubule

DNAH3 ARFGEF2 DNAH7 EFHC2 KIFAP3 DNAH12 EHHADH RP1 DYNC1H1 KLC3

1.85e-0353313010GO:0005874
GeneOntologyCellularComponentcytoplasmic region

DNAH3 ARFGEF2 DNAH7 EFHC2 KIFAP3 DNAH12 RP1 DYNC1H1

1.88e-033601308GO:0099568
GeneOntologyCellularComponentdendrite

DIP2B DSCAM FAT3 ARFGEF2 TENM2 PTPN6 ATP6AP2 LRP1 CNTNAP4 PPP1R2P1 C4A C4B SYNCRIP

2.69e-0385813013GO:0030425
GeneOntologyCellularComponentdendritic tree

DIP2B DSCAM FAT3 ARFGEF2 TENM2 PTPN6 ATP6AP2 LRP1 CNTNAP4 PPP1R2P1 C4A C4B SYNCRIP

2.74e-0386013013GO:0097447
GeneOntologyCellularComponenthistone acetyltransferase complex

KANSL1L KAT6A JADE1 KAT6B

2.83e-03941304GO:0000123
DomainPlexin_cytopl

PLXNA3 PLXND1 PLXNA1 PLXNA2

2.83e-0791314PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXND1 PLXNA1 PLXNA2

2.83e-0791314IPR013548
DomainPlexin

PLXNA3 PLXND1 PLXNA1 PLXNA2

2.83e-0791314IPR031148
DomainDynein_heavy_chain_D4_dom

DNAH3 DNAH7 DNAH12 DYNC1H1

2.19e-06141314IPR024317
DomainDynein_heavy_dom-2

DNAH3 DNAH7 DNAH12 DYNC1H1

2.19e-06141314IPR013602
DomainDHC_N2

DNAH3 DNAH7 DNAH12 DYNC1H1

2.19e-06141314PF08393
DomainAAA_8

DNAH3 DNAH7 DNAH12 DYNC1H1

2.19e-06141314PF12780
DomainDHC_fam

DNAH3 DNAH7 DNAH12 DYNC1H1

2.97e-06151314IPR026983
DomainDynein_heavy

DNAH3 DNAH7 DNAH12 DYNC1H1

2.97e-06151314PF03028
DomainDynein_heavy_dom

DNAH3 DNAH7 DNAH12 DYNC1H1

2.97e-06151314IPR004273
DomainIPT

PLXNA3 PLXND1 PLXNA1 PLXNA2

3.58e-05271314SM00429
DomainSemap_dom

PLXNA3 PLXND1 PLXNA1 PLXNA2

6.28e-05311314IPR001627
DomainSEMA

PLXNA3 PLXND1 PLXNA1 PLXNA2

6.28e-05311314PS51004
DomainTIG

PLXNA3 PLXND1 PLXNA1 PLXNA2

6.28e-05311314PF01833
DomainSema

PLXNA3 PLXND1 PLXNA1 PLXNA2

6.28e-05311314SM00630
DomainSema

PLXNA3 PLXND1 PLXNA1 PLXNA2

6.28e-05311314PF01403
DomainIPT

PLXNA3 PLXND1 PLXNA1 PLXNA2

7.14e-05321314IPR002909
DomainPlexin_repeat

PLXNA3 PLXND1 PLXNA1 PLXNA2

7.14e-05321314IPR002165
DomainPSI

PLXNA3 PLXND1 PLXNA1 PLXNA2

7.14e-05321314PF01437
DomainDynein_HC_stalk

DNAH3 DNAH7 DYNC1H1

1.16e-04141313IPR024743
DomainATPase_dyneun-rel_AAA

DNAH3 DNAH12 DYNC1H1

1.16e-04141313IPR011704
DomainMT

DNAH3 DNAH7 DYNC1H1

1.16e-04141313PF12777
DomainAAA_5

DNAH3 DNAH12 DYNC1H1

1.16e-04141313PF07728
DomainOST-HTH/LOTUS_dom

TDRD7 MARF1

1.46e-0431312IPR025605
DomainOST-HTH

TDRD7 MARF1

1.46e-0431312PF12872
DomainHTH_OST

TDRD7 MARF1

1.46e-0431312PS51644
DomainPSI

PLXNA3 PLXND1 PLXNA1 PLXNA2

2.52e-04441314IPR016201
DomainPSI

PLXNA3 PLXND1 PLXNA1 PLXNA2

3.00e-04461314SM00423
DomainRho_GTPase_activation_prot

STARD13 PLXNA3 PLXND1 PLXNA1 PLXNA2

3.87e-04881315IPR008936
DomainAnaphylatoxin_comp_syst

C4A C4B

4.82e-0451312IPR018081
DomainHAT_MYST-type

KAT6A KAT6B

4.82e-0451312IPR002717
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

4.82e-0451312IPR001840
DomainMOZ_SAS

KAT6A KAT6B

4.82e-0451312PF01853
DomainMYST_HAT

KAT6A KAT6B

4.82e-0451312PS51726
DomainANATO

C4A C4B

1.00e-0371312SM00104
DomainPlectin

EVPL PPL

1.00e-0371312PF00681
DomainANAPHYLATOXIN_2

C4A C4B

1.00e-0371312PS01178
DomainANAPHYLATOXIN_1

C4A C4B

1.00e-0371312PS01177
DomainPlectin_repeat

EVPL PPL

1.00e-0371312IPR001101
DomainANATO

C4A C4B

1.00e-0371312PF01821
DomainAnaphylatoxin/fibulin

C4A C4B

1.00e-0371312IPR000020
DomainPLEC

EVPL PPL

1.00e-0371312SM00250
DomainSpectrin_repeat

EVPL ACTN3 PPL

1.08e-03291313IPR002017
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

1.33e-0381312IPR019565
DomainThiol-ester_cl

C4A C4B

1.33e-0381312PF10569
DomainMacrogloblnA2_CS

C4A C4B

1.33e-0381312IPR019742
DomainSPEC

EVPL ACTN3 PPL

1.44e-03321313SM00150
DomainSpectrin/alpha-actinin

EVPL ACTN3 PPL

1.44e-03321313IPR018159
DomainEGF_CA

FAT3 TENM2 ADGRL4 EGF LRP1

1.69e-031221315SM00179
DomainTyr_Pase_AS

PTPN6 PTPN12 PTPRJ DUSP10

1.73e-03731314IPR016130
DomainEGF-like_Ca-bd_dom

FAT3 TENM2 ADGRL4 EGF LRP1

1.82e-031241315IPR001881
DomainPTPc

PTPN6 PTPN12 PTPRJ

2.03e-03361313SM00194
DomainA2M

C4A C4B

2.12e-03101312PF00207
DomainA2M_N_2

C4A C4B

2.12e-03101312IPR011625
DomainA2M_comp

C4A C4B

2.12e-03101312IPR011626
DomainA2M_recep

C4A C4B

2.12e-03101312PF07677
DomainA2M_comp

C4A C4B

2.12e-03101312PF07678
DomainA2M_N

C4A C4B

2.12e-03101312PF01835
DomainA2M_N

C4A C4B

2.12e-03101312IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

2.12e-03101312IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

2.12e-03101312PS00477
DomainA2M_N_2

C4A C4B

2.12e-03101312PF07703
DomainMacroglobln_a2

C4A C4B

2.12e-03101312IPR001599
DomainTYR_PHOSPHATASE_PTP

PTPN6 PTPN12 PTPRJ

2.56e-03391313PS50055
Domain-

TENM2 EGF LRP1

2.56e-033913132.120.10.30
DomainGFP-like

ADGRL4 EGF

2.58e-03111312IPR023413
Domain-

ADGRL4 EGF

2.58e-031113122.40.155.10
DomainPTPase_domain

PTPN6 PTPN12 PTPRJ

2.96e-03411313IPR000242
DomainY_phosphatase

PTPN6 PTPN12 PTPRJ

2.96e-03411313PF00102
DomainEGF_CA

FAT3 ADGRL4 EGF LRP1

3.15e-03861314PF07645
DomainTYR_PHOSPHATASE_1

PTPN6 PTPN12 PTPRJ DUSP10

3.15e-03861314PS00383
DomainTYR_PHOSPHATASE_dom

PTPN6 PTPN12 PTPRJ DUSP10

3.28e-03871314IPR000387
DomainTYR_PHOSPHATASE_2

PTPN6 PTPN12 PTPRJ DUSP10

3.28e-03871314PS50056
DomainH15

KAT6A KAT6B

3.62e-03131312SM00526
DomainH15

KAT6A KAT6B

3.62e-03131312PS51504
Domain-

PTPN6 PTPN12 PTPRJ DUSP10

4.01e-039213143.90.190.10
Domain6-blade_b-propeller_TolB-like

TENM2 EGF LRP1

4.11e-03461313IPR011042
DomainHistone_H1/H5_H15

KAT6A KAT6B

4.20e-03141312IPR005818
DomainLdl_recept_b

EGF LRP1

4.20e-03141312PF00058
DomainLDLRB

EGF LRP1

4.20e-03141312PS51120
DomainLY

EGF LRP1

4.83e-03151312SM00135
DomainLDLR_classB_rpt

EGF LRP1

4.83e-03151312IPR000033
DomainEGF_Ca-bd_CS

FAT3 ADGRL4 EGF LRP1

4.84e-03971314IPR018097
DomainEGF_CA

FAT3 ADGRL4 EGF LRP1

5.21e-03991314PS01187
DomainProt-tyrosine_phosphatase-like

PTPN6 PTPN12 PTPRJ DUSP10

5.21e-03991314IPR029021
DomainASX_HYDROXYL

FAT3 ADGRL4 EGF LRP1

5.39e-031001314PS00010
DomainEF_hand_dom

DGKB ACTN3 DNAH7 ADGRL4 EFHC2 PLS3

5.94e-032321316IPR002048
DomainIg_E-set

PLXNA3 PLXND1 PLXNA1 PLXNA2

6.19e-031041314IPR014756
DomainC345C

C4A C4B

6.20e-03171312SM00643
DomainEGF

FAT3 TENM2 ADGRL4 EGF LRP1 CNTNAP4

6.31e-032351316SM00181
DomainEGF_3

FAT3 TENM2 ADGRL4 EGF LRP1 CNTNAP4

6.31e-032351316PS50026
DomainEGF-type_Asp/Asn_hydroxyl_site

FAT3 ADGRL4 EGF LRP1

6.62e-031061314IPR000152
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

6.94e-03181312IPR008930
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C2 C4A C4B

1.34e-0571043MM14685
PathwayKEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C2 C4A C4B

2.13e-0581043M47872
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C2 C4A C4B

2.13e-0581043M27031
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA3 PLXNA1 PLXNA2

3.17e-0591043MM15030
PathwayKEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C2 C4A C4B

6.17e-05111043M47874
PathwayBIOCARTA_LECTIN_PATHWAY

C2 C4A C4B

6.17e-05111043MM1430
PathwayBIOCARTA_CLASSIC_PATHWAY

C2 C4A C4B

8.18e-05121043MM1368
PathwayBIOCARTA_LECTIN_PATHWAY

C2 C4A C4B

1.06e-04131043M4732
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PLXNA1 PLXNA2

1.34e-04141043MM15029
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA3 PLXNA1 PLXNA2

1.34e-04141043M7578
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA3 PLXNA1 PLXNA2

1.66e-04151043MM15031
PathwayBIOCARTA_CLASSIC_PATHWAY

C2 C4A C4B

1.66e-04151043M7146
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PLXNA1 PLXNA2

2.04e-04161043M16498
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA3 PLXNA1 PLXNA2

2.04e-04161043M8245
PathwayWP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY

C2 C4A C4B

2.46e-04171043MM15944
PathwayBIOCARTA_COMP_PATHWAY

C2 C4A C4B

2.46e-04171043MM1369
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

PLXND1 PLXNA1 PLXNA2

3.47e-04191043M10959
PathwayBIOCARTA_COMP_PATHWAY

C2 C4A C4B

4.06e-04201043M917
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

PLXNA3 PLXND1 PLXNA1 PLXNA2

5.35e-04511044MM14967
PathwayWP_COMPLEMENT_ACTIVATION

C2 C4A C4B

5.42e-04221043M39502
PathwayWP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER

CHD2 EGF PLXNA1 PLXNA2

6.66e-04541044M42568
Pubmed

Duplications of complement and non-complement genes of the H-2S region: evolutionary aspects of the C4 isotypes and molecular analysis of their expression variants.

C2 C4A C4B

5.72e-08313533902621
Pubmed

Identification of plexin family molecules in mice.

PLXNA3 PLXNA1 PLXNA2

5.72e-08313538806646
Pubmed

Paths reunited: Initiation of the classical and lectin pathways of complement activation.

C2 C4A C4B

5.72e-083135319783065
Pubmed

Differential expression of plexin-A subfamily members in the mouse nervous system.

PLXNA3 PLXNA1 PLXNA2

5.72e-083135311241833
Pubmed

Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.

PLXNA3 PLXND1 PLXNA1 PLXNA2

1.05e-0712135425839327
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

PLXNA3 PLXND1 PLXNA1 PLXNA2

1.05e-0712135421270798
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXNA3 PLXND1 PLXNA1 PLXNA2

1.51e-0713135410520995
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH3 DNAH7 DNAH12 DYNC1H1

2.11e-071413549373155
Pubmed

H-2 S region determined polymorphic variants of the C4, Slp, C2, and B complement proteins: a compilation.

C2 C4A C4B

2.28e-07413536190740
Pubmed

Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.

PLXNA3 PLXNA1 PLXNA2

2.28e-074135311306810
Pubmed

PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.

PLXNA3 PLXNA1 PLXNA2

2.28e-074135325518740
Pubmed

Subdivision of the S region of the mouse major histocompatibility complex by identification of genomic polymorphisms of the class III genes.

C2 C4A C4B

2.28e-07413536088393
Pubmed

Determination of cell adhesion sites of neuropilin-1.

PLXNA3 PLXNA1 PLXNA2

2.28e-074135310725340
Pubmed

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

PLXNA3 PLXNA1 PLXNA2

2.28e-07413538570614
Pubmed

The human complement system: assembly of the classical pathway C3 convertase.

C2 C4A C4B

2.28e-07413536906228
Pubmed

Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells.

C2 C4A C4B

2.28e-074135319302245
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

ASNSD1 DIP2B FNTA POLE2 SMCHD1 SHMT2 EVPL PPL PTPN6 PTPN12 ATP6AP2 LRP1 PGLS IRS2 DUSP10 PLS3 SYNCRIP

2.55e-079741351728675297
Pubmed

Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.

PLXNA3 PLXND1 PLXNA1 PLXNA2

3.81e-0716135418489001
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

PLXNA3 PLXND1 PLXNA1 PLXNA2

4.97e-0717135411683995
Pubmed

Semaphorin signaling facilitates cleft formation in the developing salivary gland.

PLXNA3 PLXND1 PLXNA1 PLXNA2

4.97e-0717135417626059
Pubmed

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

PLXNA3 PLXNA1 PLXNA2

5.69e-075135325313870
Pubmed

The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria.

C2 C4A C4B

5.69e-075135322689574
Pubmed

Formation of high affinity C5 convertase of the classical pathway of complement.

C2 C4A C4B

5.69e-075135312878586
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

FLII NRIP1 CHD2 SMC5 DNAH12 CAPN7 NCAPD2 C4A RAI14 C4B IRS2 RP1

6.00e-074971351236774506
Pubmed

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.

PLXNA3 PLXNA1 PLXNA2

1.13e-066135319480842
Pubmed

Identification of host proteins required for HIV infection through a functional genomic screen.

FLII FNTA COG3 TRAPPC8 EFHC2 USP26 EGF KMT5B SCFD1

1.27e-06272135918187620
Pubmed

An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.

PLXNA3 DSCAM PLXND1 PLXNA1 PLXNA2

1.84e-0652135526633812
Pubmed

Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.

PLXNA3 PLXNA1 PLXNA2

1.98e-067135319063725
Pubmed

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.

PLXNA3 PLXNA1 PLXNA2

1.98e-067135319655386
Pubmed

Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.

PLXNA3 PLXNA1 PLXNA2

1.98e-067135310520994
Pubmed

Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification.

PTPN6 PTPN12 PTPRJ

1.98e-06713531932742
Pubmed

The expression of plexins during mouse embryogenesis.

PLXNA3 PLXNA1 PLXNA2

3.16e-068135315661641
Pubmed

Molecular genetics of the human MHC complement gene cluster.

C2 C4A C4B

3.16e-068135310072631
Pubmed

Integration of opposing semaphorin guidance cues in cortical axons.

PLXNA3 PLXNA1 PLXNA2

3.16e-068135322368082
Pubmed

The role of neuropilins in cell signalling.

PLXNA3 PLXNA1 PLXNA2

4.72e-069135319909241
Pubmed

PlexinA2 and semaphorin signaling during cardiac neural crest development.

PLXNA3 PLXNA1 PLXNA2

4.72e-069135311688557
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

VRK2 ARFGEF2 COG3 INF2 WASHC5 ATP6AP2 RAI14 SCFD1 PCDH7 FAM135A PLXNA1

4.73e-065041351134432599
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PLXNA3 FLII KAT6A ARFGEF2 PLXND1 JADE1 RALGAPA2 AHDC1 PPP1R26 INF2 SCN5A NCAPD2 IRS2 PLXNA1 DYNC1H1 RBM38

6.48e-0611051351635748872
Pubmed

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.

PLXNA3 PLXNA1 PLXNA2

6.73e-0610135318804103
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PLXND1 ADGRL4 FAP PTPRJ VNN2 LRP1 C2 C4A

7.87e-06257135816335952
Pubmed

Organizations and gene duplications of the human and mouse MHC complement gene clusters.

C2 C4A C4B

9.22e-0611135310686478
Pubmed

On and off retinal circuit assembly by divergent molecular mechanisms.

PLXNA3 PLXNA1 PLXNA2

1.23e-0512135324179230
Pubmed

Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.

PLXNA3 PLXNA1 PLXNA2

1.23e-0512135323991118
Pubmed

PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.

PLXNA3 PLXNA1 PLXNA2

1.23e-0512135331690636
Pubmed

Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.

PLXNA3 PLXNA1 PLXNA2

1.23e-0512135328407732
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

THSD7A PLXND1 PPP1R26 HACE1 CNTNAP4 PLXNA2

1.23e-05130135612421765
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

DIP2B EPB41L4B ARFGEF2 RALGAPA2 ACE2 PTPRJ PLCB1 PCDH7 FAM135A PLXNA1 PLXNA2

1.47e-055691351130639242
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

1.50e-052135222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

1.50e-052135216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

1.50e-052135215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

1.50e-052135219062096
Pubmed

Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A.

PLXNA1 PLXNA2

1.50e-052135210781943
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

1.50e-052135219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

1.50e-05213522459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

1.50e-052135217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

1.50e-052135212207352
Pubmed

Predictive value of vrk 1 and 2 for rectal adenocarcinoma response to neoadjuvant chemoradiation therapy: a retrospective observational cohort study.

VRK1 VRK2

1.50e-052135227456229
Pubmed

Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope.

EVPL PPL

1.50e-052135211062259
Pubmed

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.

VRK1 VRK2

1.50e-052135228790404
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

1.50e-052135227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

1.50e-052135222387014
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

1.50e-052135223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

1.50e-052135223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

1.50e-05213523037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

1.50e-052135211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

1.50e-05213524216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

1.50e-05213526950384
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

1.50e-05213528660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

1.50e-05213528428773
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

1.50e-052135224638111
Pubmed

Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement.

C2 C4A

1.50e-05213526019133
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

1.50e-052135221345967
Pubmed

Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase.

VRK1 VRK2

1.50e-05213529344656
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

1.50e-05213522572548
Pubmed

The complement component C4 of mammals.

C4A C4B

1.50e-05213522302180
Pubmed

Two clusters of acidic amino acids near the NH2 terminus of complement component C4 alpha'-chain are important for C2 binding.

C2 C4B

1.50e-052135210946278
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

1.50e-052135222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

1.50e-052135218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

1.50e-052135229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

1.50e-05213526589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

1.50e-052135225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

1.50e-052135217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

1.50e-05213526149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

1.50e-05213526149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

1.50e-052135212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

1.50e-05213523542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

1.50e-05213522387317
Pubmed

Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity.

KAT6A CD8A

1.50e-052135227653692
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

1.50e-052135216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

1.50e-05213527365238
Pubmed

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes.

EGF SYNCRIP

1.50e-052135229884818
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

1.50e-05213527391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

1.50e-052135217971360
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

1.50e-052135229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

1.50e-052135217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

1.50e-05213526881182
Pubmed

ERα status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B.

KAT6A KAT6B

1.50e-052135239505971
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

1.50e-052135217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

1.50e-052135221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

1.50e-05213526978711
Cytoband8p11

FNTA KAT6A

5.13e-05413528p11
GeneFamilyPlexins

PLXNA3 PLXND1 PLXNA1 PLXNA2

8.10e-089934683
GeneFamilyDyneins, axonemal

DNAH3 DNAH7 DNAH12

8.50e-0517933536
GeneFamilyEF-hand domain containing|Plakins

EVPL PPL

7.18e-048932939
GeneFamilyComplement system|Sushi domain containing

C2 C4A C4B

8.32e-0436933492
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

9.20e-0499321234
GeneFamilyZinc fingers C2HC-type|PHD finger proteins|Lysine acetyltransferases

KAT6A KAT6B

3.00e-031693266
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT6A KAT6B

3.39e-0317932486
GeneFamilyProtein tyrosine phosphatases, non-receptor type

PTPN6 PTPN12

3.80e-0318932812
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

STARD13 NRIP1 SMCHD1 KAT6A BARD1 ZMYM2 TRAPPC8 SMC5 TDRD7 PTPN12 MARF1 KAT6B

5.15e-0646613412M13522
CoexpressionPARENT_MTOR_SIGNALING_UP

FLII PDK2 KAT6A SHMT2 DYRK4 DENND2B PTPN6 ATP6AP2 CAPN7 IRAK4 LRP1 PLCB1 KAT6B

7.20e-0656713413M16909
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

STARD13 NRIP1 VRK1 SMCHD1 KAT6A BARD1 ZMYM2 MED1 TRAPPC8 SMC5 DENND2B AHDC1 TDRD7 KIFAP3 PTPN12 KAT6B

8.14e-0685613416M4500
CoexpressionWANG_SMARCE1_TARGETS_UP

DIP2B NRIP1 PLXND1 DENND2B IFIT3 FAP PLCB1 DIO2 PCDH7

2.13e-052941349M1804
CoexpressionCASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP

ZMYM2 SMC5 BCL11B CD8A PLCB1 IRS2 KAT6B

3.26e-051741347M2038
CoexpressionHUANG_DASATINIB_SENSITIVITY_UP

DENND2B IFIT3 RAI14 DUSP10 PCDH7

5.73e-05801345M3015
CoexpressionGSE13485_PRE_VS_POST_YF17D_VACCINATION_PBMC_UP

NRIP1 THSD7A FAT3 JADE1 TENM2 RP1 UGT2B28

5.88e-051911347M3310
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

FNTA SMCHD1 KAT6A TRPS1 CHD2 JADE1 MED1 TRAPPC8 SMC5 PRDM1 PTPN6 BCL11B CD8A PTPRJ ATP6AP2 IRAK4 GPCPD1 KAT6B DYNC1H1 RBM38

7.19e-05149213420M40023
CoexpressionGSE360_HIGH_VS_LOW_DOSE_B_MALAYI_DC_UP

STARD13 GRIN2C MED1 DNAH7 SCG2 MARF1 SCFD1

7.38e-051981347M5222
CoexpressionGSE24142_ADULT_VS_FETAL_DN3_THYMOCYTE_UP

NRIP1 EPB41L4B JADE1 MED1 LRP1 DIO2 SYNCRIP

7.86e-052001347M4584
CoexpressionGSE40666_WT_VS_STAT1_KO_CD8_TCELL_UP

NRIP1 PLXND1 BCL11B INF2 DUSP10 KLC3 RBM38

7.86e-052001347M9205
CoexpressionBRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A

DNAJB12 DSCAM EVPL ACTN3 MED1 TENM2 ANKRD18B ADGRL4 ACE2 BCL11B CNTNAP4 C2 MOBP PLXNA2 DMTN

8.53e-0593013415MM893
CoexpressionDELYS_THYROID_CANCER_UP

FLII NRIP1 EVPL PLXND1 PPL PRDM1 FAP C2 C4A PCDH7

1.01e-0444513410M3645
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#4_top-relative-expression-ranked_500

NRIP1 FAT3 TRPS1 CHD2 ACE2 FAP LRP1 PLXNA2

9.40e-061751258gudmap_developingGonad_e14.5_ epididymis_500_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_1000

THSD7A EPB41L4B FAT3 TRPS1 COG3 TENM2 RBM20 PRDM1 FAP PTPN12 BCL11B CNTNAP4 RXFP1 KAT6B FAM135A SYNCRIP

3.26e-0583612516gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_500

NRIP1 RAPH1 ARFGEF2 GPCPD1 PARPBP PCDH7 SYNCRIP

5.15e-051631257gudmap_developingKidney_e15.5_cortic collect duct_500_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#3_top-relative-expression-ranked_1000

TRPS1 PRDM1 BCL11B RXFP1 KAT6B SYNCRIP

7.10e-051181256gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_500

TRPS1 ARFGEF2 TENM2 PRDM1 BCL11B DIO2 RXFP1 KAT6B PCDH7 SYNCRIP

1.06e-0439012510gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_500
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_1000

FAT3 TRPS1 NUF2 DNAH7 DENND2B KIFAP3 ACE2 FAP NCAPD2 LRP1 CYB5D1 KAT6B PCDH7 PLS3 PLXNA2

1.12e-0483112515gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_1000
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPS1 RBM20 OR1L8 BCL11B CNTNAP4 RAI14 RXFP1 PLXNA2

8.29e-08182134872e65a23cd36085bc880087d3cae92395de918a1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPS1 RBM20 OR1L8 BCL11B CNTNAP4 RAI14 RXFP1 PLXNA2

8.29e-08182134805c167158815bf25d509df59ab386e1990712765
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A TRPS1 GRIN2C BCL11B SCG2 SCN5A DUSP10

1.07e-0617613474843af68f013732c28a8b8edad30d5fa0f2b084b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A TRPS1 GRIN2C BCL11B SCG2 SCN5A DUSP10

1.20e-0617913473b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A TRPS1 GRIN2C BCL11B SCG2 SCN5A DUSP10

1.30e-061811347153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCellPBMC-Severe-Hematopoietic-RBC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IFIT3 MARF1 C4A C4B KLC3 DMTN RBM38

1.50e-061851347d685a5a2e525db2eba449cfa1e5cd54eb36162a8
ToppCellPBMC-Severe-Hematopoietic-RBC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

IFIT3 MARF1 C4A C4B KLC3 DMTN RBM38

1.50e-0618513475d8d6fd7800f76ee3aa5cef95241d8e6d7e8db04
ToppCellPBMC-Severe-Hematopoietic-RBC-RBC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IFIT3 MARF1 C4A C4B KLC3 DMTN RBM38

1.50e-061851347100b5afdf3c6ab07ffc493f7883f5a7b31c59184
ToppCellCOVID-19_Severe-Hematopoietic_R|COVID-19_Severe / Disease group, lineage and cell class

IFIT3 MARF1 C4A C4B KLC3 DMTN RBM38

1.50e-06185134730f064ab7c3890e6f419a845276b145112e78f52
ToppCellPBMC-Severe-Hematopoietic-RBC-RBC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IFIT3 MARF1 C4A C4B KLC3 DMTN RBM38

1.50e-061851347f3b1907c3b6f930bc161f46efce5e143babab507
ToppCellPBMC-Severe-Hematopoietic-RBC-RBC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IFIT3 MARF1 C4A C4B KLC3 DMTN RBM38

1.50e-06185134744ce50cb99df8ffc50eba311adcf688477618659
ToppCellPBMC-Severe-Hematopoietic-RBC-RBC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IFIT3 MARF1 C4A C4B KLC3 DMTN RBM38

1.50e-06185134717542ccd52a821c9e99b1a7469e80502e764b3fd
ToppCellCOVID-19_Severe-Hematopoietic_R-RBC|COVID-19_Severe / Disease group, lineage and cell class

IFIT3 MARF1 C4A C4B KLC3 DMTN RBM38

1.50e-0618513473ed6090b822c6d1d400a421236cddc7511743932
ToppCellControl-Endothelial_cells-Arterial_endothelial_cells|Control / group, cell type (main and fine annotations)

THSD7A RALGAPA2 ADGRL4 OTC PLCB1 RXFP1 PLXNA2

1.61e-06187134781affaab3fe3e1daea45ada6445e906ddd33950e
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 FAT3 ASCL3 DNAH7 DNAH12 SCG2 RP1

1.73e-061891347cd4746ea6ae48a7dd14a2960d38d9445a738cf2c
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

THSD7A RALGAPA2 PTPN12 ZNF804B RAI14 PCDH7 PLXNA2

1.73e-06189134775c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

THSD7A RALGAPA2 ADGRL4 OTC PLCB1 RXFP1 PLXNA2

1.85e-06191134750601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 DNAH7 DENND2B ANKRD18B RP1 PCDH7 PLXNA2

1.99e-061931347ea345d34440b25f65358a53dc72831998d1c3620
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

VRK1 POLE2 BARD1 NUF2 BCL11B NCAPD2 PARPBP

2.13e-061951347764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 TENM2 AHDC1 FAP DIO2 C4A C4B

2.35e-0619813477a0c4dbc8c99968d42af00a718f4fedc544599ec
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NUF2 BCL11B CD8A NCAPD2 PARPBP RBM38

7.30e-061541346f78b01c19afcbab6319f61e4d6023ecb3d510d24
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

DNAH3 DSCAM FAT3 DGKB TENM2 RXFP1

8.76e-0615913465335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPB41L4B NUF2 C4A C4B MOBP

1.02e-05951345a09443e527d37adb637a66ca857525dab1c39a9b
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GJB4 EVPL PPL C2 C4B MOBP

1.16e-051671346c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GJB4 EVPL PPL C2 C4B MOBP

1.16e-051671346351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-2|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

DNAJB12 HDAC5 FAM117B DENND2B KIFAP3 KLC3

1.20e-051681346c70bf73bb800e4722cedc35bbc17ea3113d1012d
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POLE2 ARFGEF2 EVPL DYRK4 C4A PLXNA1

1.20e-051681346b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCell10x_5'_v1-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IFIT3 FAP DIO2 RAI14 PLS3 PLXNA2

1.28e-051701346dfef8f79960979335b86b4730f224239b40735d5
ToppCell10x_5'_v1-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IFIT3 FAP DIO2 RAI14 PLS3 PLXNA2

1.28e-051701346fb6098137d010175978596bc382e9ecba9c3891e
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

SMCHD1 KAT6A CHD2 BCL11B KAT6B CCDC144A

1.33e-0517113462e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLXND1 TENM2 ADGRL4 PLCB1 RAI14 KLC3

1.33e-051711346b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A TRPS1 GRIN2C BCL11B SCG2 DUSP10

1.42e-051731346d17e50dc400098374af626803dec1241ec566769
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A TRPS1 GRIN2C SCG2 SCN5A DUSP10

1.56e-05176134695d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT3 PLXND1 DNAH7 ANKRD18B ZNF804B RXFP1

1.66e-0517813460e1bedf991189d0ef9b40dac9281bdf4739333a1
ToppCellLPS-IL1RA-Endothelial-Endothelial-FOXM1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

POLE2 BARD1 NUF2 NCAPD2 PARPBP RPE65

1.77e-051801346334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DNAH3 THSD7A BCL11B SCG2 SCN5A CNTNAP4

1.77e-051801346b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPS1 RBM20 BCL11B CNTNAP4 RXFP1 PLXNA2

1.77e-051801346e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A TRPS1 GRIN2C BCL11B SCN5A DUSP10

1.83e-0518113467704f236831cffe4f2a75d4c461eb88b4177e206
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD30B ADGRL4 FAP ZNF804B RXFP1 PLXNA2

1.89e-051821346205d9ad1ea4b7adee8054496cdde46c9c401a19a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADGRL4 OR1L8 SCG2 ZNF804B RXFP1 PLXNA2

2.01e-051841346ca35a3d2b536c8b2bf5c4d635605e5a3ae94a428
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD7A ADGRL4 PTPRJ CNTNAP4 RP1 FAM135A

2.13e-0518613462d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KANSL1L HARBI1 EFHC2 SCG2 IRS2 CYB5D1

2.13e-051861346f5468e03321ea2083e223eb0d92c3a9307039569
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_EGR3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADGRL4 OR1L8 SCG2 ZNF804B RXFP1 PLXNA2

2.13e-05186134677b09af860183606a1775eba921e2071e4a7dd4e
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

BARD1 SHMT2 PRDM1 PTPN12 NCAPD2 PARPBP

2.26e-05188134634873972dff9284dfcd26bb698c9d1df007f1cbb
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

THSD7A RALGAPA2 ADGRL4 PTPN12 PCDH7 PLXNA2

2.33e-051891346c81787a8c662db5d7814c583dd64562857629e81
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD7A PLXND1 ADGRL4 CNTNAP4 PLCB1 RP1

2.40e-051901346aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellCOVID-19-Endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

THSD7A RALGAPA2 ADGRL4 PLCB1 RXFP1 PLXNA2

2.40e-0519013469fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

VRK1 FAT3 BARD1 PARPBP RPE65 PLXNA2

2.40e-051901346e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BARD1 NUF2 BCL11B CD8A NCAPD2 PARPBP

2.47e-051911346239300ff76f2c855b2b04d3002461158be90a01b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KANSL1L DNAH7 PPL PTPRJ PLCB1 RP1

2.62e-051931346f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

VRK1 POLE2 BARD1 NUF2 NCAPD2 PARPBP

2.62e-0519313464b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tregs|blood / Manually curated celltypes from each tissue

SMCHD1 SHMT2 PRDM1 BCL11B DUSP10 RBM38

2.62e-0519313462ffe44edf2b02d11a7c10513692eb697a10f911e
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KANSL1L NRIP1 PLXND1 BCL11B CD8A KMT5B

2.62e-051931346a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

THSD7A RAPH1 RALGAPA2 PTPN12 PCDH7 PLXNA2

2.62e-0519313462531266bc57339d4e2b22a88817008e32b8c1598
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KANSL1L DNAH7 PPL PTPRJ PLCB1 RP1

2.62e-05193134642df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellIPF-Endothelial-VE_Peribronchial|IPF / Disease state, Lineage and Cell class

THSD7A RALGAPA2 ADGRL4 PLCB1 RAI14 PLS3

2.78e-0519513462c3ad3cb79f11119ac69c413a938d21199145040
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLXND1 ADGRL4 PLCB1 RAI14 RXFP1 PLS3

2.86e-051961346c5fe470f11ee4962bcfb30cddfd8c078af5b1222
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THSD7A PLXND1 ADGRL4 FAP PLCB1 RXFP1

2.86e-051961346a0ba408b802fa6d6e42e6d234b6879fdb1583f81
ToppCell3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THSD7A PLXND1 ADGRL4 PLCB1 RAI14 PLS3

3.03e-05198134699be7a7a84199dac598e993a5a0144d9030f13ce
ToppCell3'-Child04-06-SmallIntestine-Endothelial|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THSD7A PLXND1 ADGRL4 PLCB1 RAI14 PLS3

3.03e-051981346bf4e086c3fc924e999b6eaca87d2beee9b9526c2
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

VRK1 POLE2 BARD1 NUF2 NCAPD2 PARPBP

3.03e-0519813466981cd5b1585c8ae6febdf0c4fb83067127f106c
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 EPB41L4B DNAH7 EFHC2 DNAH12 RP1

3.03e-051981346d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCellCOVID-19_Mild-Classical_Monocyte|COVID-19_Mild / Disease condition and Cell class

PLXND1 VNN2 LRP1 PLCB1 GPCPD1 IRS2

3.03e-05198134630ada3de865b6fb2b14196a1cbfd4740c6a57ce3
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A TRPS1 GRIN2C BCL11B SCG2 DUSP10

3.20e-0520013462441a36d363b799a4692aa697f969cda056c2d60
ToppCelldistal-3-Hematologic-Platelet/Megakaryocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH3 EPB41L4B DNAH7 RBM20 ANKRD18B DNAH12

3.20e-052001346f5f5a8b0e4d802d95dc42646dd5e7d7daaad72b4
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

THSD7A ADGRL4 CNTNAP4 PLCB1 RP1 FAM135A

3.20e-05200134665b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3-|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A TRPS1 GRIN2C BCL11B SCG2 DUSP10

3.20e-052001346c7bca638229bd4fd2414171e73fa949e36a10a92
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GJB4 SMCHD1 RBM20 PRDM1 BCL11B CD8A

3.20e-052001346510d84bf7a4621b079e5a7330d25e04508c84a49
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3--L2-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A TRPS1 GRIN2C BCL11B SCG2 DUSP10

3.20e-052001346d841dbe2297c3bf62f49bae5921662cd6a47e5c2
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA3 NUF2 IFIT3 C4A C4B

3.54e-051231345a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Nr2f2_Necab1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

STARD13 THSD7A IFIT3 CNTNAP4 DUSP10

3.68e-051241345298ff8bd8f0459f44ce8a8aea889c6f1cf84ac5f
ToppCellSevere-CD8+_T|World / Disease group and Cell class

RBM20 FCRL3 CD8A PLCB1

4.16e-056413443e7ede6ec5d8b9c4fc6f3aa8fda91fd9b763ef18
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

VRK1 MED1 CD8A FAM135A PLXNA2

6.57e-051401345276b3fa924176426efb31112ed4d355407f0b218
ToppCellCOVID-19-kidney-Mito-rich_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD7A ADGRL4 USP26 PLCB1 RPE65

7.76e-051451345afed661aef990edb8e7012ab67ace56443520c9f
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

SMCHD1 CHD2 PRDM1 BCL11B CD8A

9.39e-051511345999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCellLPS-antiTNF-Stromal_mesenchymal-Fibroblasts-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NRIP1 PRDM1 TMX2 CNTNAP4 PARPBP

9.39e-051511345f13a117ae26ae525da4f3e837d8f204d00dc6ee3
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

ADGRL4 FAP DIO2 RAI14 UGT2B28

1.03e-041541345511923b27469ea20f8bd82a9ec27119a6e884644
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

DIP2B NRIP1 PRDM1 SERPINB13 LRP1

1.09e-041561345ffb9249a115ce31f50b99a7a3d40bf48b9d7f2b0
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANKRD30B RBM20 EGF CNTNAP4 RP1

1.20e-041591345c186bf05c61fac348cf41973827cced83fafd58a
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM117B HARBI1 EGF CYB5D1 DEPDC7

1.27e-041611345ed93cb6c133855a5c244821e1a260aae8ab4df9a
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM117B HARBI1 EGF CYB5D1 DEPDC7

1.27e-0416113450089d7bb305c592392791862a3341fc92af8f3e2
ToppCellBasal_cells-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

TENM2 AHDC1 ANKRD18B SERPINB13 PCDH7

1.34e-041631345679e25e5548d157d49a73057a3b5617dccda260f
ToppCellCiliated_cells-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

DNAH3 ANKRD18B EFHC2 DNAH12 RP1

1.38e-0416413450e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCellBAL-Severe-cDC_8|Severe / Compartment, Disease Groups and Clusters

POLE2 IFIT3 PRDM1 IRS2 DEPDC7

1.38e-041641345e8cbe7e01eca32886eb44e02d5333056b6bebc50
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BARD1 NUF2 BCL11B NCAPD2 PARPBP

1.42e-04165134526c750f10f6401752e2e63d91dc844c81b29d735
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPN6 INF2 NCAPD2 PARPBP PLXNA1

1.42e-0416513451dcd6b8aa192baeaa1f7bb334843edab6049b96f
ToppCell15-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

THSD7A FAT3 USP26 DIO2 RPE65

1.42e-041651345531804467601e1ee1f771cffa21501f6d464ae10
ToppCelldroplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POLE2 BARD1 NUF2 NCAPD2 DEPDC7

1.42e-04165134596f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D122|Adult / Lineage, Cell type, age group and donor

STARD13 TRPS1 PLXND1 LRP1 DEPDC7

1.46e-041661345be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSCAM FAP SCG2 ZNF804B C4A

1.46e-04166134566026988509e39e41274fa0de738383219e8ff30
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 DNAH7 DNAH12 RP1 WDR17

1.59e-041691345fba841664939c771881ba97f14ef1df6635c04ff
ToppCellfacs-SCAT-Fat-18m-Lymphocytic-T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUF2 BCL11B CD8A DUSP10 PARPBP

1.59e-041691345700a3a36c379872585204caa6a6cc269b036ae22
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPH1 TRPS1 PLXND1 LRP1 PLCB1

1.64e-041701345a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DYRK4 ASCL3 BCL11B CD8A SCG2

1.64e-04170134567e78e3c1d4cd3c6eaa5d0a9785b6cd8a3b08039
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPH1 TRPS1 PLXND1 LRP1 PLCB1

1.64e-041701345ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPH1 PLXND1 LRP1 PLCB1 DEPDC7

1.77e-041731345807183fc23478da9451906dacd88de4e73112e0d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A TRPS1 GRIN2C SCN5A DUSP10

1.77e-04173134561907116a1460bc157ba73b5edd108db7dd5de4b
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SMCHD1 RALGAPA2 IFIT3 FAP VNN2

1.77e-0417313455b76d9cc56bbb29017e64a2d0a3c76c0be003d96
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SMCHD1 RALGAPA2 IFIT3 FAP VNN2

1.77e-041731345bf685025961e79b379f2c35464b6c8ce3e31ace0
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SMCHD1 RALGAPA2 IFIT3 FAP VNN2

1.77e-041731345a6e73a40b0d5356564a594053e772f9d061a5919
Diseaseneuroblastoma

KANSL1L VRK1 VRK2 BARD1 DGKB NUF2 TENM2 HACE1

5.17e-081161318EFO_0000621
Diseaseserum IgG glycosylation measurement

THSD7A DSCAM TRPS1 CHD2 RALGAPA2 ADGRL4 BCL11B EGF KMT5B EHHADH ZNF804B HACE1 RPE65 MOBP

9.36e-0852313114EFO_0005193
DiseaseLupus Erythematosus, Systemic

PRDM1 IRAK4 C2 C4A C4B

1.64e-05711315C0024141
Diseasephosphatidylcholine 36:4 measurement

VRK1 UGT2B28 UGT2B11

6.65e-05181313EFO_0010382
Diseaseurate measurement, bone density

DSCAM SLC26A5 GRIN2C TENM2 PPL BCL11B PLCB1 C2 SCFD1 KAT6B FAM135A

1.04e-0461913111EFO_0003923, EFO_0004531
Diseaseglucose metabolism disease (implicated_via_orthology)

DGKB DIO2 IRS2

2.58e-04281313DOID:4194 (implicated_via_orthology)
DiseaseComplement deficiency disease

C2 C4A C4B

4.23e-04331313C0272242
Diseasehematocrit

ASNSD1 STARD13 NRIP1 RAPH1 TRPS1 DENND2B ADGRL4 BCL11B PTPRJ PLCB1 RAI14 IRS2 RBM38

5.80e-04101113113EFO_0004348
DiseaseColon Carcinoma

PTPN12 PTPRJ

6.90e-0491312C0699790
Diseasesystemic lupus erythematosus (implicated_via_orthology)

PRDM1 C4A C4B

9.27e-04431313DOID:9074 (implicated_via_orthology)
DiseaseEpithelioid Cell Uveal Melanoma

VRK2 OR1L8

1.05e-03111312EFO_1000244
Diseaseextrapulmonary tuberculosis

THSD7A DGKB

1.25e-03121312MONDO_0000368
Diseasealcohol consumption measurement

VRK1 VRK2 THSD7A RAPH1 TRPS1 JADE1 MED1 TENM2 BCL11B PTPRJ HACE1 PLCB1 DIO2 PLXNA2

1.27e-03124213114EFO_0007878
Diseaselung adenocarcinoma (is_implicated_in)

PRDM1 EGF PTPRJ

1.36e-03491313DOID:3910 (is_implicated_in)
Diseasecortical thickness

DIP2B FLII VRK2 FAT3 TRPS1 ARFGEF2 PLXND1 TENM2 BCL11B LRP1 PCDH7 MOBP PLXNA2

1.39e-03111313113EFO_0004840
Diseasefatty acid measurement, fetal genotype effect measurement, breast milk measurement

COG3 ZNF804B

1.48e-03131312EFO_0005110, EFO_0007959, EFO_0009092
Diseaseage at first sexual intercourse measurement

VRK2 TRPS1 SMC5 TENM2 HARBI1 HACE1 C2

1.66e-033831317EFO_0009749
Diseasefatty acid measurement, breast milk measurement, parental genotype effect measurement

COG3 ZNF804B

1.72e-03141312EFO_0005110, EFO_0005939, EFO_0009092
Diseasefasting blood glucose measurement

DSCAM FAT3 TRPS1 DGKB CNTNAP4 PLCB1

1.82e-032871316EFO_0004465
Diseaseneuropsychological test

NRIP1 BCL11B EHHADH PLCB1 MOBP

1.90e-031971315EFO_0003926
Diseaselung disease severity measurement

VRK2 DGKB BCL11B KMT5B

1.93e-031181314EFO_0007744
Diseasecoronary thrombosis, GM11992

DSCAM EPB41L4B

2.25e-03161312EFO_0001124, EFO_1000883
Diseasereticulocyte count

TRPS1 FAM117B DENND2B TMX2 CD8A EGF PTPRJ PLCB1 RAI14 C4B IRS2 RBM38

2.44e-03104513112EFO_0007986
Diseasehypertrophic cardiomyopathy (is_marker_for)

ADGRL4 ACE2

2.55e-03171312DOID:11984 (is_marker_for)
Diseaseresponse to paliperidone, schizophrenia symptom severity measurement

SMC5 TENM2 FAP PTPN6 PLCB1

2.83e-032161315EFO_0007925, EFO_0007927
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

BARD1 PTPRJ

3.18e-03191312C1333991
DiseaseDiGeorge syndrome (implicated_via_orthology)

KAT6A PLXND1

3.18e-03191312DOID:11198 (implicated_via_orthology)
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

BARD1 PTPRJ

3.18e-03191312C2936783
DiseaseAlzheimer disease, gastroesophageal reflux disease

NRIP1 THSD7A RBM20 DNAH12 KLC3

3.57e-032281315EFO_0003948, MONDO_0004975
Diseasebiological sex

FAT3 TENM2 BCL11B PTPRJ PCDH7

3.70e-032301315PATO_0000047
Diseaseanorexia nervosa

THSD7A ADGRL4 ZNF804B

3.77e-03701313MONDO_0005351

Protein segments in the cluster

PeptideGeneStartEntry
QKYLGKNSKPNELES

USP26

626

Q9BXU7
IFPKRKAAYDSNGNV

ADGRL4

281

Q9HBW9
KSPKINLNYAGDDLR

ANKRD30B

1241

Q9BXX2
NYLTSKKSLPLENNG

BARD1

306

Q99728
AINEKLGQYASPTAK

C4B

686

P0C0L5
YAKKLRQAFQGDSIP

PGLS

126

O95336
KGRPYANQKLFASLL

ARFGEF2

1536

Q9Y6D5
LKRGANPNIKDIYGN

ANKRD18B

121

A2A2Z9
LFLSDGKLKSNLYQP

CNTNAP4

421

Q9C0A0
SSAPYGKNQVQALKD

POLE2

326

P56282
GSTNNYKSLKPKLEN

CCDC144CP

411

Q8IYA2
LYLSQNKPKAAEGLD

CD8A

71

P01732
DSQLGKENKLYSPAR

DEPDC7

141

Q96QD5
KQKLASPQPSYAADA

AHDC1

591

Q5TGY3
QNKKSDVYGNDSLIP

C7orf31

116

Q8N865
YEADKNPKSKPSNGL

DENND2B

396

P78524
TSLAQEYKGNLLLKP

CYB5D1

46

Q6P9G0
KKGADLNLVDSLGYN

RAI14

206

Q9P0K7
AKSDKYLKQQQDAPG

RBM20

766

Q5T481
GRKANVNLAYLGAKP

RBM38

101

Q9H0Z9
KNPQNYLLGKKETAE

RAPH1

361

Q70E73
LNPFIYSLRNKDIKG

OR7A2P

286

Q8NGA2
IPKKSNDSQNRLYGK

PARPBP

536

Q9NWS1
KLNPKTGLIDYNQLA

SHMT2

196

P34897
PNGSSLKNIEKYLRS

KAT6B

121

Q8WYB5
NPYLLQSNKTKGDPL

PTPRJ

271

Q12913
AYKQVKLGEDAPNSS

DIO2

71

Q92813
LGEPSCNKLKNILYN

KANSL1L

101

A0AUZ9
KLYLNSNKLDFDGLP

FLII

296

Q13045
LYDLVSKLKLPNNGR

MAGEB5

106

Q9BZ81
AKNLAAAEGLEPKYQ

PPP1R2P1

101

Q96PQ5
KLNLDGSNYTLLKQG

LRP1

3041

Q07954
LYNPCLGSADKNSRK

C2

701

P06681
ASDIKLEPNTLNGYK

KMT5B

551

Q4FZB7
DGDKPKILLYSLNLQ

KIAA1109

3146

Q2LD37
GLFNYKRLPATDSNK

DUSP10

366

Q9Y6W6
QLEPSDYLKKLASQG

EHHADH

691

Q08426
KADGYNQPDSKRRQT

SYNCRIP

566

O60506
QNTDKYPFSNLKLAL

EFHC2

536

Q5JST6
KAPNAEDLSYVNRKG

HARBI1

156

Q96MB7
DPRQTFLYKLSNKAG

FAM135A

1396

Q9P2D6
ANLFNKYPALTKPEN

PLS3

371

P13797
LGKDSPSNKLLYAKD

PLXNA1

1791

Q9UIW2
QAAYLAKPGDSLAQA

PLXNA2

311

O75051
LGKDSPSNKLLYAKD

PLXNA3

1766

P51805
LQLGKDSPTNKLLYA

PLXND1

1811

Q9Y4D7
ADGKNLTKNDLYPNP

NUF2

26

Q9BZD4
ASKPNGQRYDSVNEK

PCDH7

956

O60245
YAKENGTKLLLTNDP

OTC

236

P00480
LRKVDSDLNQKYGPD

PPL

336

O60437
KLNSNLDAKYSPAPG

EVPL

351

Q92817
LVLLLKKGANPNYQD

HACE1

81

Q8IYU2
LAYTLLNKLGTKNEP

DIP2B

381

Q9P265
AAGNLKLKYPNENED

DNAH12

1436

Q6ZR08
SPKNAGYKNSLERNN

NRIP1

356

P48552
DPNVAKTKNNLASAY

KLC3

371

Q6P597
NPFIYSLRNKDIKGA

OR1J1

286

Q8NGS3
AATLPNEYKEGKLQA

RALGAPA2

1001

Q2PPJ7
GDAQALKPLKFSSNQ

INF2

1106

Q27J81
ALLKNASLAGAPKYI

PDK2

6

Q15119
NPFIYSLRNKDVKGA

OR7D4

286

Q8NG98
ADGKLLPNGDYLNVS

IRS2

756

Q9Y4H2
LKVSNKGLNSYKDPD

KAT6A

61

Q92794
LKDGPLYRLNTKATN

KAT6A

161

Q92794
LEAKQAKNPASPYNL

ATP6AP2

281

O75787
ALKLFKNQLSPYEQS

DYRK4

41

Q9NR20
LRNPSYIQEAKAKGL

GPCPD1

566

Q9NPB8
ALPQYGELLADKQKR

BCL11B

606

Q9C0K0
KQGPVKDAYSLANNP

CAPN7

556

Q9Y6W3
TAAGNLKLKYPEENE

DNAH3

1611

Q8TD57
KGNNSHILLSALKYP

EGF

146

P01133
KKQPAYLGGENLELR

CHD2

471

O14647
AQPAKVNDLAATAYK

COG3

741

Q96JB2
RDKENGNNSPLPKYA

FAM117B

441

Q6P1L5
LSNPEKRKQYDQFGD

DNAJB12

161

Q9NXW2
AAGNLKLKYPNENEE

DNAH7

1511

Q8WXX0
YNLTLQAKDKGSPQK

FAT3

341

Q8TDW7
DYSNKALEKGLNPLN

IFIT3

316

O14879
PNAPSLYDNLSKKRG

GJB4

111

Q9NTQ9
GSTNNYKSLKPKLEN

CCDC144B

461

Q3MJ40
VLAKYNPEGKQDILN

DGKB

41

Q9Y6T7
KNKARSGENPYASID

ACE2

771

Q9BYF1
SLLYPDKAETKNNPG

ASCL3

146

Q9NQ33
DGKQLPNSYNLEKIT

FCRL3

136

Q96P31
VYNLPANKDGKSVSN

MARF1

516

Q9Y4F3
EDLLYNLKQRGPNSS

ASNSD1

21

Q9NWL6
GPNSSKQLLKSDVNY

ASNSD1

31

Q9NWL6
GYAGRSNLPDNLKKL

DYNC1H1

2021

Q14204
AVAIKKPSGDDRYNQ

IRAK4

36

Q9NWZ3
LYGTSPLNRQKLDSK

HDAC5

751

Q9UQL6
GSTNNYKSLKPKLEN

CCDC144A

461

A2RUR9
NQVLGYKDLAAIPKD

DMTN

36

Q08495
RGKSPAQAELSYLNK

EPB41L4B

251

Q9H329
AINEKLGQYASPTAK

C4A

686

P0C0L4
LLPKLTALLGNDNYK

KIFAP3

386

Q92845
GLVNLYNLPGDNKLK

MED1

156

Q15648
KLSSGLDIYRNPLKN

OR5T3

21

Q8NGG3
PEKYLALEKNDSQNL

RP1

296

P56715
NPFIYSLRNKDLKQG

OR1L8

286

Q8NGR8
NPLLYSLRNKDVKGA

OR10Q1

291

Q8NGQ4
YAKNRIGKSEPSNEL

DSCAM

961

O60469
GQKPAYLLILNAKDL

RPE65

496

Q16518
KYATGKPDQKDLNEN

STARD13

836

Q9Y3M8
NYNLKVTLPGLKEDS

SMCHD1

901

A6NHR9
NNRLKPLTLAYDGDA

THSD7A

1641

Q9UPZ6
LYSNALKRKTGVNPA

SLC26A5

551

P58743
KGILQDRGLSKYPNL

FNTA

281

P49354
NRNYSKSTELPGKNE

PTPN12

406

Q05209
QSAPKENKPYALNSE

SCG2

126

P13521
LDLQASKKLPDLYGN

SCN5A

56

Q14524
KSNNPLSSELDLKNY

TENM2

2461

Q9NT68
AKEGPRLSKNQKYSE

MOBP

6

Q13875
NPFIYSLRNKDVKGA

OR7D2

286

Q96RA2
AIQEYLKAKSGAAQP

PPP1R26

136

Q5T8A7
LDSNPSKGKDLYRSN

PRDM1

256

O75626
KGQDDSLLPQNYCKG

WDR17

766

Q8IZU2
SGGQDLLLYPAKRKQ

TDRD7

291

Q8NHU6
KSKLKSDNENDGYVP

JADE1

791

Q6IE81
DISDYPKLLANKQSN

SPATA9

221

Q9BWV2
DYAKLRKDDPIGNLN

ACTN3

206

Q08043
YLNPKGDSARAKAQA

NCAPD2

701

Q15021
GLPTKDDNLEHYKNS

FAP

666

Q12884
DNSIYVLANLGDKKP

VNN2

131

O95498
YQRAKKLSKAGDNIP

TMX2

261

Q9Y320
LPQQYPASGENKSKD

TRPS1

866

Q9UHF7
PLYLNTSLKDCAGKN

ZNF804B

581

A4D1E1
PYKAAKTALNNTLDL

WASHC5

306

Q12768
EDLQAKILGIPYKNN

SERPINB13

226

Q9UIV8
KDLKELSQLNLSYNP

RXFP1

316

Q9HBX9
YKKALTDAGCNLNPL

SCFD1

476

Q8WVM8
GNKPDALGLNTRLYK

UGT2B11

341

O75310
EKYEPNNSLARKGQI

PLCB1

276

Q9NQ66
GDIKASNLLLNYKNP

VRK1

176

Q99986
YIKNQLLGPDENAKT

PTPN6

306

P29350
LSLYEDKQNPTKGAL

ZMYM2

406

Q9UBW7
KSINDLKNTSGLLYP

TRAPPC8

401

Q9Y2L5
NAKDDLPGVYQKLLD

TTC37

91

Q6PGP7
GNKPDALGLNTRLYK

UGT2B28

341

Q9BY64
ADKAPSRSLNELKQY

SMC5

546

Q8IY18
DIKAANLLLGYKNPD

VRK2

166

Q86Y07
SGLSDKKFQRPQDQY

GRIN2C

661

Q14957