Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribosomal protein S6 kinase activity	RPS6KA4 RPS6KA1 RPS6KA6	1.04e-05	7	135	3	GO:0004711
GeneOntologyMolecularFunction	histone H3S28 kinase activity	RPS6KA4 RPS6KA5	1.36e-04	3	135	2	GO:0044022
GeneOntologyMolecularFunction	histone H3S10 kinase activity	RPS6KA4 RPS6KA5	2.70e-04	4	135	2	GO:0035175
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	GRIA1 GRM1	2.70e-04	4	135	2	GO:0099583
GeneOntologyCellularComponent	ER to Golgi transport vesicle membrane	CIDEB HLA-DQB1 GRIA1 SEC24B SEC13	5.46e-05	64	133	5	GO:0012507
GeneOntologyCellularComponent	vacuolar membrane	CCZ1B ABCA3 ATP6V0A1 PSAP HLA-DQB1 TLR7 ENTPD4 SLC46A3 MAP1LC3C ABCA5 CCZ1 SEC13	9.80e-05	507	133	12	GO:0005774
GeneOntologyCellularComponent	COPII vesicle coat	CIDEB SEC24B SEC13	1.33e-04	16	133	3	GO:0030127
GeneOntologyCellularComponent	lysosomal membrane	CCZ1B ABCA3 ATP6V0A1 PSAP HLA-DQB1 TLR7 ENTPD4 SLC46A3 ABCA5 CCZ1 SEC13	1.83e-04	462	133	11	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	CCZ1B ABCA3 ATP6V0A1 PSAP HLA-DQB1 TLR7 ENTPD4 SLC46A3 ABCA5 CCZ1 SEC13	1.83e-04	462	133	11	GO:0098852
GeneOntologyCellularComponent	Mon1-Ccz1 complex	CCZ1B CCZ1	3.97e-04	5	133	2	GO:0035658
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	MOXD2P CIDEB ABCA3 ATP6V0A1 STAB2 PSAP HLA-DQB1 ZPBP GNPNAT1 GRIA1 TLR7 MALRD1 SLC15A2 ABCA5 SEC24B RAB15 CADPS2 PICK1 SEC13	6.17e-04	1307	133	19	GO:0030659
GeneOntologyCellularComponent	COPII-coated ER to Golgi transport vesicle	CIDEB HLA-DQB1 GRIA1 SEC24B SEC13	6.94e-04	110	133	5	GO:0030134
GeneOntologyCellularComponent	vesicle membrane	MOXD2P CIDEB ABCA3 ATP6V0A1 STAB2 PSAP HLA-DQB1 ZPBP GNPNAT1 GRIA1 TLR7 MALRD1 SLC15A2 ABCA5 SEC24B RAB15 CADPS2 PICK1 SEC13	7.28e-04	1325	133	19	GO:0012506
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RGPD3	1.10e-03	8	133	2	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RGPD3	1.75e-03	10	133	2	GO:0044614
GeneOntologyCellularComponent	lysosome	CCZ1B ABCA3 ATP6V0A1 PSAP HLA-DQB1 TLR7 ENTPD4 SLC46A3 ABCA5 CCZ1 CTBS CTSB SEC13	2.02e-03	811	133	13	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	CCZ1B ABCA3 ATP6V0A1 PSAP HLA-DQB1 TLR7 ENTPD4 SLC46A3 ABCA5 CCZ1 CTBS CTSB SEC13	2.02e-03	811	133	13	GO:0000323
GeneOntologyCellularComponent	vacuole	CCZ1B ABCA3 ATP6V0A1 PSAP HLA-DQB1 TLR7 ENTPD4 SLC46A3 MAP1LC3C ABCA5 CCZ1 CTBS CTSB SEC13	2.05e-03	913	133	14	GO:0005773
GeneOntologyCellularComponent	zona pellucida receptor complex	ZPBP ZPBP2	2.13e-03	11	133	2	GO:0002199
GeneOntologyCellularComponent	endocytic vesicle membrane	ATP6V0A1 STAB2 HLA-DQB1 GRIA1 SLC15A2 PICK1	2.39e-03	212	133	6	GO:0030666
GeneOntologyCellularComponent	coated vesicle membrane	CIDEB ATP6V0A1 HLA-DQB1 GRIA1 SEC24B SEC13	2.56e-03	215	133	6	GO:0030662
GeneOntologyCellularComponent	inclusion body	RGPD4 PSAP RGPD3 EDEM1	2.62e-03	90	133	4	GO:0016234
HumanPheno	Granular macular appearance	CFH CHM CFI	2.65e-05	9	36	3	HP:0007793
HumanPheno	Reduced circulating complement concentration	CFH TLR7 CFI CR2 MASP2	4.62e-05	58	36	5	HP:0004431
HumanPheno	Abnormality of complement system	CFH TLR7 CFI CR2 MASP2	5.91e-05	61	36	5	HP:0005339
HumanPheno	Hypotension	CFH SLC25A20 ABCA3 PSAP HMGCL CFI	9.66e-05	109	36	6	HP:0002615
HumanPheno	Decreased circulating complement C3 concentration	CFH TLR7 CFI CR2	2.13e-04	43	36	4	HP:0005421
HumanPheno	Chorioretinal atrophy	CFH CHM CFI EYS	2.33e-04	44	36	4	HP:0000533
HumanPheno	Hypoautofluorescent macular lesion	CFH CFI	2.89e-04	4	36	2	HP:0030632
HumanPheno	Reticular pigmentary degeneration	CFH CFI	2.89e-04	4	36	2	HP:0007937
HumanPheno	Decreased circulating complement factor H concentration	CFH CFI	2.89e-04	4	36	2	HP:0005369
HumanPheno	Prolonged prothrombin time	CFH HLA-DQB1 HMGCL CFI	3.28e-04	48	36	4	HP:0008151
HumanPheno	Abnormal prothrombin time	CFH HLA-DQB1 HMGCL CFI	3.84e-04	50	36	4	HP:0032199
HumanPheno	Abnormality of prothrombin	CFH HLA-DQB1 HMGCL CFI	4.47e-04	52	36	4	HP:0012200
HumanPheno	Exudative retinal detachment	CFH CFI	4.79e-04	5	36	2	HP:0012231
HumanPheno	Paroxysmal supraventricular tachycardia	SLC19A2 TNNI3K	4.79e-04	5	36	2	HP:0004763
HumanPheno	Placental abruption	CFH CFI	4.79e-04	5	36	2	HP:0011419
HumanPheno	Peripapillary chorioretinal atrophy	CFH CFI	4.79e-04	5	36	2	HP:0007950
HumanPheno	Decreased circulating complement factor I concentration	CFH CFI	4.79e-04	5	36	2	HP:0005356
HumanPheno	Decreased circulating complement factor B concentration	CFH CFI	4.79e-04	5	36	2	HP:0005416
HumanPheno	Chorioretinal degeneration	CFH CHM CFI EYS	5.17e-04	54	36	4	HP:0200065
HumanPheno	Choroidal neovascularization	CFH CHM CFI	5.21e-04	23	36	3	HP:0011506
HumanPheno	Preeclampsia	CFH SLC25A20 CFI	5.21e-04	23	36	3	HP:0100602
Domain	Ribosomal_S6_kinase_II	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6	3.33e-08	6	130	4	IPR016239
Domain	Pkinase_C	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6 DMPK	1.05e-05	42	130	5	PF00433
Domain	AGC-kinase_C	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6 DMPK	4.35e-05	56	130	5	IPR000961
Domain	AGC_KINASE_CTER	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6 DMPK	4.35e-05	56	130	5	PS51285
Domain	S_TK_X	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6 DMPK	4.35e-05	56	130	5	SM00133
Domain	Sp38-bd	ZPBP ZPBP2	4.81e-05	2	130	2	IPR010857
Domain	DUF1712	CCZ1B CCZ1	4.81e-05	2	130	2	PF08217
Domain	Sp38	ZPBP ZPBP2	4.81e-05	2	130	2	PF07354
Domain	DUF1712_fun	CCZ1B CCZ1	4.81e-05	2	130	2	IPR013176
Domain	Pkinase_C	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6	1.24e-04	37	130	4	IPR017892
Domain	HAD-SF_hydro_IG_5-nucl	NT5DC1 NT5C2	2.86e-04	4	130	2	IPR008380
Domain	5_nucleotid	NT5DC1 NT5C2	2.86e-04	4	130	2	PF05761
Domain	Sushi	CFH CR2 F13B MASP2	4.68e-04	52	130	4	PF00084
Domain	CCP	CFH CR2 F13B MASP2	5.41e-04	54	130	4	SM00032
Domain	SUSHI	CFH CR2 F13B MASP2	6.22e-04	56	130	4	PS50923
Domain	Sushi_SCR_CCP_dom	CFH CR2 F13B MASP2	6.65e-04	57	130	4	IPR000436
Domain	Rab_bind	RGPD4 RGPD3	9.87e-04	7	130	2	PF16704
Domain	GCC2_Rab_bind	RGPD4 RGPD3	9.87e-04	7	130	2	IPR032023
Pathway	WP_COMPLEMENT_AND_COAGULATION_CASCADES	CFH CFI CR2 F13B SERPINC1 MASP2	2.92e-06	58	98	6	M39649
Pathway	WP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES	CFH CFI CR2 F13B SERPINC1 MASP2	3.24e-06	59	98	6	M48343
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	CFH CFI CR2 F13B SERPINC1 MASP2	8.14e-06	69	98	6	M16894
Pubmed	The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation.	RPS6KA4 RPS6KA5 CHUK	2.28e-07	4	135	3	24519526
Pubmed	Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers.	RPS6KA4 RPS6KA5 CLEC7A	5.69e-07	5	135	3	23533666
Pubmed	Proteome-wide characterization of N-glycosylation events by diagonal chromatography.	CFH CFI F13B IL1R2 SERPINC1 MASP2	5.78e-07	77	135	6	16944957
Pubmed	Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function.	RPS6KA4 RPS6KA5 RPS6KA1	3.16e-06	8	135	3	10922375
Pubmed	Integrative predictive model of coronary artery calcification in atherosclerosis.	CFH TLR7 F13B CHUK IL1R2 PRKAG1 DMPK MASP2	3.38e-06	229	135	8	19948975
Pubmed	Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases.	RPS6KA4 RPS6KA5 RPS6KA1	6.73e-06	10	135	3	29229781
Pubmed	The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	21166721
Pubmed	Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia.	HIF1A PPP1R3C	1.50e-05	2	135	2	20888814
Pubmed	PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease.	HIF1A PRMT3	1.50e-05	2	135	2	38200452
Pubmed	Association between vitamin D status and age-related macular degeneration by genetic risk.	CFH CFI	1.50e-05	2	135	2	26312598
Pubmed	Characterization of the cellular action of the MSK inhibitor SB-747651A.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	21970321
Pubmed	p38{alpha} MAP kinase controls IL-17 synthesis in vogt-koyanagi-harada syndrome and experimental autoimmune uveitis.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	20164464
Pubmed	The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-activated kinase signalling pathway.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	18513320
Pubmed	mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination.	GRIA1 GRM1	1.50e-05	2	135	2	10846166
Pubmed	Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus).	CFH CFI	1.50e-05	2	135	2	21936007
Pubmed	A role of mitogen and stress-activated protein kinase 1/2 in survival of lipopolysaccharide-stimulated RAW 264.7 macrophages.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	15681159
Pubmed	Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	15128846
Pubmed	Cloning of novel splice variants of mouse mGluR1.	GRIA1 GRM1	1.50e-05	2	135	2	10581402
Pubmed	Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	36812480
Pubmed	Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	21314333
Pubmed	The Role of a Novel TRMT1 Gene Mutation and Rare GRM1 Gene Defect in Intellectual Disability in Two Azeri Families.	TRMT1 GRM1	1.50e-05	2	135	2	26308914
Pubmed	The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells.	RPS6KA5 RPS6KA1	1.50e-05	2	135	2	12769834
Pubmed	Factor I-mediated processing of complement fragments on HIV immune complexes targets HIV to CR2-expressing B cells and facilitates B cell-mediated transmission of opsonized HIV to T cells.	CFI CR2	1.50e-05	2	135	2	16920989
Pubmed	Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	25451279
Pubmed	Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	23127194
Pubmed	Differential localization of MAPK-activated protein kinases RSK1 and MSK1 in mouse brain.	RPS6KA5 RPS6KA1	1.50e-05	2	135	2	15893597
Pubmed	Comprehensive analysis of the RSK gene family in acute myeloid leukemia determines a prognostic signature for the prediction of clinical prognosis and treatment responses.	RPS6KA4 RPS6KA1	1.50e-05	2	135	2	37462338
Pubmed	The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	27973548
Pubmed	Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.	CUL2 HIF1A	1.50e-05	2	135	2	20078552
Pubmed	Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies.	CFH CFI	1.50e-05	2	135	2	25803806
Pubmed	MSK activation and physiological roles.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	18508628
Pubmed	A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis.	GRM1 PICK1	1.50e-05	2	135	2	37209824
Pubmed	Identification of cathepsin B as a novel target of hypoxia-inducible factor-1-alpha in HepG2 cells.	HIF1A CTSB	1.50e-05	2	135	2	29935187
Pubmed	Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis.	ZPBP ZPBP2	1.50e-05	2	135	2	17664285
Pubmed	Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	23020821
Pubmed	Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	26611568
Pubmed	Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells.	HIF1A STC1	1.50e-05	2	135	2	16109785
Pubmed	Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction.	RPS6KA4 RPS6KA5	1.50e-05	2	135	2	34445361
Pubmed	Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.	RPS6KA4 RPS6KA5 RPS6KA1	2.02e-05	14	135	3	9687510
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD4 LAMA1 RGPD3	2.52e-05	15	135	3	14697343
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	LAMA1 GRIA1 PICK1	4.47e-05	18	135	3	14730302
Pubmed	Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	19933278
Pubmed	MicroRNA-574-3p Regulates HIF-α Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.	CUL2 HIF1A	4.48e-05	3	135	2	34655362
Pubmed	Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree.	CFH CFI	4.48e-05	3	135	2	16386793
Pubmed	Ultrastructures and interactions of complement factors H and I.	CFH CFI	4.48e-05	3	135	2	1401896
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	4.48e-05	3	135	2	32160108
Pubmed	Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses.	CUL2 HIF1A	4.48e-05	3	135	2	25326537
Pubmed	Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.	CFH CFI	4.48e-05	3	135	2	28671664
Pubmed	Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome.	CFH CFI	4.48e-05	3	135	2	17599974
Pubmed	Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.	CFH CR2	4.48e-05	3	135	2	19828624
Pubmed	Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts.	PSAP CTSB	4.48e-05	3	135	2	22949512
Pubmed	Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	23675462
Pubmed	Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	20864036
Pubmed	MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	28593137
Pubmed	Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.	CFH CFI	4.48e-05	3	135	2	18202746
Pubmed	The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response.	HIF1A TLR7	4.48e-05	3	135	2	19381167
Pubmed	Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome.	CFH CFI	4.48e-05	3	135	2	18658028
Pubmed	Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	17495961
Pubmed	Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	26109721
Pubmed	Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.	CFH CFI	4.48e-05	3	135	2	16621965
Pubmed	IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1α/PFKFB3 pathway.	HIF1A IL1R2	4.48e-05	3	135	2	38097102
Pubmed	A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.	CFH CR2	4.48e-05	3	135	2	3782802
Pubmed	RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	23719381
Pubmed	Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	24792438
Pubmed	Differential regulation of the phosphorylation of Trimethyl-lysine27 histone H3 at serine 28 in distinct populations of striatal projection neurons.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	26947946
Pubmed	CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	24438093
Pubmed	A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration.	CFH CFI	4.48e-05	3	135	2	36643920
Pubmed	Genotype-phenotype correlations of low-frequency variants in the complement system in renal disease and age-related macular degeneration.	CFH CFI	4.48e-05	3	135	2	29888403
Pubmed	Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1.	GRIA1 GRM1	4.48e-05	3	135	2	14614461
Pubmed	Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia.	CFH CFI	4.48e-05	3	135	2	22514678
Pubmed	Interactions between human complement components factor H, factor I and C3b.	CFH CFI	4.48e-05	3	135	2	9291131
Pubmed	MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription.	RPS6KA4 RPS6KA5	4.48e-05	3	135	2	17668895
Pubmed	Genetic mapping of the T lymphocyte-specific transcription factor 7 gene on mouse chromosome 11.	TCF7 GRIA1	4.48e-05	3	135	2	7626895
Pubmed	Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration.	CFH CFI	4.48e-05	3	135	2	30253188
Pubmed	Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression.	GRIA1 GRM1	4.48e-05	3	135	2	16421200
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RGPD4 PLXNA3 GGNBP2 GRIA1 KRBA2 HMGCL TKTL1 ATP5MK CXXC1 CHUK OR10G7 OR10G4 RGPD3 OR10G9 CADPS2 PICK1 MYBPC1	4.57e-05	1442	135	17	35575683
Pubmed	Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.	CFH CFI F13B SERPINC1	8.37e-05	59	135	4	17330941
Pubmed	mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors.	GRIA1 GRM1	8.93e-05	4	135	2	30190524
Pubmed	Identification and characterization of human ZPBP-like gene in silico.	ZPBP ZPBP2	8.93e-05	4	135	2	12883658
Pubmed	Genetic disorders in complement (regulating) genes in patients with atypical haemolytic uraemic syndrome (aHUS).	CFH CFI	8.93e-05	4	135	2	20106822
Pubmed	The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation.	RPS6KA4 RPS6KA5	8.93e-05	4	135	2	16517600
Pubmed	Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling.	HIF1A CLEC7A	8.93e-05	4	135	2	31139177
Pubmed	Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions.	CUL2 HIF1A	8.93e-05	4	135	2	16261165
Pubmed	MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.	RPS6KA4 RPS6KA5	8.93e-05	4	135	2	11909979
Pubmed	Dynamic HIF1A regulation during human placental development.	CUL2 HIF1A	8.93e-05	4	135	2	16611863
Pubmed	Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.	RPS6KA4 RPS6KA5	8.93e-05	4	135	2	25233930
Pubmed	The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1 alpha prolyl hydroxylation.	HIF1A TLR7	8.93e-05	4	135	2	19841637
Pubmed	Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.	GRIA1 GRM1	8.93e-05	4	135	2	19657020
Pubmed	Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways.	RPS6KA4 RPS6KA5	8.93e-05	4	135	2	27795299
Pubmed	Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity.	CUL2 HIF1A	8.93e-05	4	135	2	11865071
Pubmed	Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability.	CUL2 SERPINC1	8.93e-05	4	135	2	34324733
Pubmed	New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3.	CFH CFI	8.93e-05	4	135	2	25188723
Pubmed	Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components.	CFH CFI	8.93e-05	4	135	2	24983375
Pubmed	Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.	SEC24B SEC13	8.93e-05	4	135	2	18713835
Pubmed	Rare Genetic Variants Associated With Development of Age-Related Macular Degeneration.	CFH CFI	8.93e-05	4	135	2	26767664
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	8.93e-05	4	135	2	20305638
Pubmed	Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein.	CUL2 HIF1A	8.93e-05	4	135	2	11024059
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	CUL2 RPS6KA5 RPS6KA1 CXXC1 TNNI3K RPS6KA6 ZC3H7B DMPK	1.08e-04	372	135	8	22939624
Pubmed	An anti-interferon activity shared by paramyxovirus C proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon induction.	TLR7 CHUK	1.48e-04	5	135	2	24269682
Pubmed	Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins.	RPS6KA4 RPS6KA5	1.48e-04	5	135	2	20307261
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6	1.46e-07	11	85	4	1156
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH CR2 F13B MASP2	1.49e-04	57	85	4	1179
GeneFamily	Complement system\|Sushi domain containing	CFH CFI CR2	6.40e-04	36	85	3	492
GeneFamily	ATP binding cassette subfamily A	ABCA3 ABCA5	1.92e-03	14	85	2	805
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD4 RGPD3 FKBP8 ZC3H7B	2.12e-03	115	85	4	769
GeneFamily	Olfactory receptors, family 10	OR10G7 OR10G4 OR10G9	3.71e-03	66	85	3	157
Coexpression	HALLMARK_COAGULATION	CFH TFPI2 CFI F13B RGN SERPINC1 CTSB MASP2	5.74e-07	138	134	8	M5946
Coexpression	GSE28408_LY6G_POS_VS_NEG_DC_UP	TIGAR ATP6V0A1 RAPGEF6 RPS6KA5 ENTPD4 SLC46A3 ABCA5 PGAP1	8.20e-06	197	134	8	M9547
ToppCell	droplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH CFI F13B PPP1R3C RGN SERPINC1	6.52e-06	151	134	6	cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRMT10B TFPI2 PPP1R3C PARPBP MASP2 MYBPC1	6.52e-06	151	134	6	f13a117ae26ae525da4f3e837d8f204d00dc6ee3
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue-3\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RPS6KA5 CECR2 GRIA1 IGSF10 ART4 RPS6KA6	7.30e-06	154	134	6	4e9203c220a44c70cd7979796a0b461991422257
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCF7 EYS MALRD1 BCO2 PRPF38A PARPBP	7.57e-06	155	134	6	4559e3011514041b65c17ae4ede29da202bce14c
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1-Excitatory_Neuron.Slc17a7.Fibcd1-Grm5_(CA1_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ERV3-1 DNAH14 TNNI3K ZPBP2	9.31e-06	44	134	4	598044d7c325bc48ac8ab0c0722b4bb263028d71
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8\|TCGA-Liver / Sample_Type by Project: Shred V9	CFH CFI F13B SLC46A3 SERPINC1 EDEM1	1.33e-05	171	134	6	c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIDEB PECR ABCA3 ENTPD4 GGCT CNDP1	1.33e-05	171	134	6	48fc4eca18b102b5ec5050f758281292ee8e10c6
ToppCell	droplet-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIDEB PECR ABCA3 ENTPD4 GGCT CNDP1	1.33e-05	171	134	6	05fcc72df50a380a913821b5781d9621df37d328
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 MFSD4A GRM1 DNAH14 MALRD1 RPS6KA6	1.51e-05	175	134	6	e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 MYCT1 DOCK9 GRIA1 STC1 ST6GALNAC3	1.89e-05	182	134	6	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	Immune_cells-Dendritic_cells\|Immune_cells / Lineage and Cell class	PSAP RPS6KA1 TLR7 SLC46A3 ABCA5 CTSB	1.89e-05	182	134	6	99c7d4f1e7cd745643ba64b59190113bcd4e348e
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 MYCT1 DOCK9 GRIA1 STC1 ST6GALNAC3	2.01e-05	184	134	6	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	CECR2 MFSD4A MALRD1 ST6GALNAC3 PATJ CADPS2	2.07e-05	185	134	6	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	CFH DOCK9 STC1 ART4 ST6GALNAC3 CADPS2	2.33e-05	189	134	6	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STAB2 MYCT1 DOCK9 GRIA1 ART4 ST6GALNAC3	2.40e-05	190	134	6	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	Control-Myeloid-Transitioning_MDM\|Control / group, cell type (main and fine annotations)	HIF1A PSAP HLA-DQB1 CLEC7A IL1R2 CTSB	2.40e-05	190	134	6	d6fd8c23cde4a10cc1517b6899a5a855fdfff2e2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STAB2 MYCT1 DOCK9 GRIA1 ART4 ST6GALNAC3	2.40e-05	190	134	6	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STAB2 MYCT1 DOCK9 GRIA1 ART4 ST6GALNAC3	2.40e-05	190	134	6	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	IPF-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	MYCT1 DOCK9 CFI STC1 ART4 ST6GALNAC3	2.40e-05	190	134	6	ac029e73da5995221c9b9af551d85e4b835e21d6
ToppCell	LAM-Endothelial-LymEndo\|LAM / Condition, Lineage and Cell class	STAB2 MYCT1 PGM2L1 STC1 ART4 ST6GALNAC3	2.62e-05	193	134	6	68eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PSAP HLA-DQB1 CLEC7A TLR7 OLFML3 CTSB	2.62e-05	193	134	6	fc2eb6a7b4f1e687bf37e59e3cd52b14f99ffea4
ToppCell	NS-critical-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFH GNPNAT1 MFSD4A CFI SLC15A2 CADPS2	2.70e-05	194	134	6	2172d951896265243d14996eacce5aab5e14e26e
ToppCell	ASK440-Endothelial-Lymphatic\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	STAB2 MYCT1 CFI STC1 ART4 ST6GALNAC3	2.70e-05	194	134	6	4aa68e39e36094359dfbedf1e9bdf3ea5c32ed1a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PSAP HLA-DQB1 CLEC7A TLR7 OLFML3 CTSB	2.78e-05	195	134	6	b6bf75669f267ecdc96818c7022db852e37a9fe1
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PSAP HLA-DQB1 CLEC7A TLR7 OLFML3 CTSB	2.86e-05	196	134	6	efdc95811e8b17243065ae82d748ea2c5775fdbc
ToppCell	distal-mesenchymal-Lipofibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH TFPI2 SLC19A2 CFI OLFML3 PGAP1	2.94e-05	197	134	6	865010edcd7e3f79f505fcef7b33882095994aa8
ToppCell	distal-3-Endothelial-Lymphatic\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	STAB2 MYCT1 CFI STC1 ART4 ST6GALNAC3	2.94e-05	197	134	6	9ea0e2ed9c3f97591a06e70570640996580417d5
ToppCell	distal-mesenchymal-Lipofibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH TFPI2 SLC19A2 CFI OLFML3 PGAP1	2.94e-05	197	134	6	ceb83bdef16b58ee16193413bfb006f7715728b2
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Lymphatic\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	STAB2 MYCT1 DOCK9 STC1 ART4 ST6GALNAC3	3.11e-05	199	134	6	88f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	STAB2 MYCT1 DOCK9 STC1 ART4 ST6GALNAC3	3.11e-05	199	134	6	64b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HIF1A PSAP HLA-DQB1 CLEC7A OLFML3 CTSB	3.11e-05	199	134	6	550590b1e9c1930cbbe9cf7a141c7aeb07413096
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	STAB2 MYCT1 DOCK9 STC1 ART4 ST6GALNAC3	3.11e-05	199	134	6	2b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCell	ASK454-Immune-B_cell\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	ABCA3 PSAP HLA-DQB1 CLEC7A EDEM1 CTSB	3.11e-05	199	134	6	b9b0ae81b9e7e35023c73d3b936e88167461ba54
ToppCell	Entopeduncular-Macroglia-ASTROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CIDEB STAB2 ERV3-1 AK9 SLC15A2	4.45e-05	129	134	5	c37bdd6c0b2944fbfa064922954ea0e263160e2a
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CIDEB STAB2 ERV3-1 AK9 SLC15A2	4.45e-05	129	134	5	8648ae59f7aca0f5b4983bdb4a65b03b2ca761e1
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 CECR2 ABCA5 PATJ CADPS2	4.62e-05	130	134	5	6434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TFPI2 PPP1R3C PARPBP MASP2 MYBPC1	7.26e-05	143	134	5	57ee1830d96d73d92b5f83b028592a5d952c6013
ToppCell	Cerebellum-Macroglia-ASTROCYTE\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CIDEB ERV3-1 PPP1R3C SLC15A2 MYBPC1	9.39e-05	151	134	5	71841d2001200d1595c85c2b007ee20791a72927
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CIDEB ERV3-1 PPP1R3C SLC15A2 MYBPC1	9.39e-05	151	134	5	60aced0c1cc6b509b73308d03d58a3c44d712ef4
ToppCell	droplet-Heart-nan-3m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCT1 CR2 NT5DC1 BCO2 CTBS	1.13e-04	157	134	5	d85a2f56ae313baa9738e81d2756ce1fe1ba50db
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RPS6KA5 GRIA1 IGSF10 ART4 RPS6KA6	1.16e-04	158	134	5	8e48952af0831a1fc71ad422e8216b5a92a75991
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RPS6KA5 GRIA1 IGSF10 ART4 RPS6KA6	1.16e-04	158	134	5	e5b55c15a8c99c8d7fc94949f0d3c22e0c3fee7b
ToppCell	facs-Liver\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH STAB2 CFI RGN SERPINC1	1.16e-04	158	134	5	ea7db6bd9742153ceb6e444892a6d1df9c7fcc96
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RPS6KA5 GRIA1 IGSF10 ART4 RPS6KA6	1.16e-04	158	134	5	55214d674808584e4d48f8c5e3b8c0e206cb9bb8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PSAP TKTL1 GRM1 IL1R2	1.21e-04	84	134	4	9ffce86c3491a464fbec9b9e5e6e7b7cc28afa88
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFI F13B RGN PCYT2 SERPINC1	1.23e-04	160	134	5	8de1fc75241d9bf2b355afa0e9ef39fea1977177
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STAB2 DOCK9 TMOD4 MFSD4A GGCT	1.31e-04	162	134	5	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	droplet-Lung-nan-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TKTL1 PKD2L2 SLC15A2 ZPBP2 PARPBP	1.34e-04	163	134	5	5efecdd8a069a822bc9d35b407092925a865e629
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TKTL1 PKD2L2 SLC15A2 ZPBP2 PARPBP	1.34e-04	163	134	5	0d94a427f86e62aba12c397c6d7b8cd297f3a0e5
ToppCell	droplet-Liver-Hepatocytes-21m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIDEB PECR PPP1R3C RGN SERPINC1	1.38e-04	164	134	5	c9866a289e120be4066e66275c3beb97ba67cca4
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIDEB TCF7 PPP1R3C BCO2 DMPK	1.38e-04	164	134	5	b895674ed2df87db8fbfb30b7e31620945588491
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_T_naive\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	TCF7 RAPGEF6 GCNT4 SERPINC1 PATJ	1.51e-04	167	134	5	78d264af390bd89942ffbb2991dc94f50756d4c9
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMOD4 CR2 SHISAL2B PARPBP MYBPC1	1.51e-04	167	134	5	d78356bf0c473816dbabaee51984940bd822f84e
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPS6KA4 PSAP SLC19A2 BCO2 IL1R2	1.55e-04	168	134	5	93b7138f17aa14a6398c9b4ea7237781a0e19a66
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPS6KA4 PSAP SLC19A2 BCO2 IL1R2	1.55e-04	168	134	5	e393553208617a023f1646169c892a87c95db3f5
ToppCell	390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|390C / Donor, Lineage, Cell class and subclass (all cells)	HLA-DQB1 CLEC7A TLR7 MAP1LC3C CTSB	1.59e-04	169	134	5	2c851b2703c7b8b656026f996f5fc027e4a79b36
ToppCell	metastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs\|Myeloid_cells / Location, Cell class and cell subclass	HLA-DQB1 L2HGDH CFI BCO2 MYBPC1	1.73e-04	172	134	5	38d17e769fe8eac8b57b820490d4ddd969243ee7
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-stromal_related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH OLFML3 IGSF10 RGN MAP1LC3C	1.87e-04	175	134	5	b8995e7ada85ba959f06264a0295b61e390c4e6c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH OLFML3 IGSF10 RGN MAP1LC3C	1.87e-04	175	134	5	7ae76bd3b4f610b2f98716a4456437cd3696b686
ToppCell	droplet-Liver-LIVER-NPC-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECR TFPI2 GNPNAT1 RGN PCYT2	2.08e-04	179	134	5	10baf575f06f9a15384bcdc751446b4670acf942
ToppCell	wk_08-11-Mesenchymal-Mesothelial-Late_mesothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH PECR ABCA3 TFPI2 SLC15A2	2.25e-04	182	134	5	f8257c884393f168f605d371e0840cfca8d3657e
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TCF7 DOCK9 ATP5MK PGAP1 PATJ	2.25e-04	182	134	5	1aea96ee211f7b9caef7fd385233f51be6021a73
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TCF7 DOCK9 ATP5MK PGAP1 PATJ	2.25e-04	182	134	5	b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCF7 DOCK9 ATP5MK PGAP1 PATJ	2.25e-04	182	134	5	c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA3 STAB2 MYCT1 CR2 ART4	2.25e-04	182	134	5	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZHX3 LAMA1 MFSD4A MALRD1 RPS6KA6	2.25e-04	182	134	5	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCF7 DOCK9 ATP5MK PGAP1 PATJ	2.25e-04	182	134	5	4cb182ef39be2044a6ad7266f332d4177591e550
ToppCell	COVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated\|COVID-19_Mild / Disease group, lineage and cell class	TCF7 DOCK9 ATP5MK PGAP1 PATJ	2.30e-04	183	134	5	7717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCell	COVID-19-Heart-EC_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYCT1 DOCK9 STC1 ST6GALNAC3 CADPS2	2.30e-04	183	134	5	ff95382cfed592190d0636d2b750328471f82e0d
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PSAP HLA-DQB1 LAMA1 APIP CTSB	2.30e-04	183	134	5	02deb595819fb864a934fd0fcaad684f1ca42964
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	HLA-DQB1 CHUK ABCA5 IL1R2 EDEM1	2.30e-04	183	134	5	3cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PSAP HLA-DQB1 CLEC7A IL1R2 CTSB	2.36e-04	184	134	5	ba260f8a2e6e510141a6b9c458eb0040acff0352
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HIF1A PSAP CLEC7A IL1R2 CTSB	2.36e-04	184	134	5	d7f348aa8901d819c68da20728b9238407bcdca9
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CFH MYCT1 DOCK9 MUC19 EYS	2.36e-04	184	134	5	a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCF7 NT5DC1 TRAPPC13 PGAP1 PATJ	2.36e-04	184	134	5	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCF7 RAPGEF6 DOCK9 TRAPPC13 PATJ	2.36e-04	184	134	5	5350b58aa9979631228835d11eb45ddf81d08bff
ToppCell	droplet-Spleen-nan-21m-Lymphocytic-T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIF1A TCF7 B4GALNT4 IL1R2 CTSB	2.42e-04	185	134	5	ea3ff0bd3f312bd2e93227ecf6ed577366aab3e0
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	STAB2 MYCT1 DOCK9 ART4 ST6GALNAC3	2.42e-04	185	134	5	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HIF1A PSAP HLA-DQB1 OLFML3 CTSB	2.42e-04	185	134	5	76fc5bbb71e42c0eb70474efcd3a71a7b2633f24
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	STAB2 MYCT1 DOCK9 ART4 ST6GALNAC3	2.42e-04	185	134	5	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRMT10B MYCT1 MFSD4A OLFML3 ST6GALNAC3	2.48e-04	186	134	5	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PSAP HLA-DQB1 CLEC7A OLFML3 CTSB	2.48e-04	186	134	5	e4de270d38bbed022f545bd0bbaa9599e707ec87
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRMT10B MYCT1 MFSD4A OLFML3 ST6GALNAC3	2.48e-04	186	134	5	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA3 DOCK9 DNAH14 PATJ CADPS2	2.48e-04	186	134	5	acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRMT10B MYCT1 MFSD4A OLFML3 ST6GALNAC3	2.48e-04	186	134	5	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	COPD-Endothelial-VE_Arterial\|World / Disease state, Lineage and Cell class	MYCT1 DOCK9 STC1 ST6GALNAC3 CADPS2	2.54e-04	187	134	5	be42ee71d3412bb1f52593d8814de85c354a0efa
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZHX3 HIF1A LAMA1 DNAH14 PATJ	2.54e-04	187	134	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	CFH ERV3-1 TFPI2 CFI SLC15A2	2.54e-04	187	134	5	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HIF1A RAPGEF6 CLEC7A OLFML3 CTSB	2.54e-04	187	134	5	2a7226adb4d15b92936603bdf05421c50b21f003
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TFPI2 MYCT1 DOCK9 MUC19 EYS	2.61e-04	188	134	5	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|368C / Donor, Lineage, Cell class and subclass (all cells)	CUL2 PECR SLC25A20 CHM PATJ	2.61e-04	188	134	5	ecc2364d946f97ae0212fd6739960c9fc75e4919
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PSAP HLA-DQB1 CLEC7A OLFML3 CTSB	2.61e-04	188	134	5	3f47395db7e6159fc95810545bad4b6e028464c5
ToppCell	LAM-Myeloid-DC\|LAM / Condition, Lineage and Cell class	HLA-DQB1 CLEC7A OLFML3 BCO2 IL1R2	2.61e-04	188	134	5	b4140110c2f7d25fd8a0d2749e33e02003ac4bf2
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECR TFPI2 ATP5MK F13B CHUK	2.61e-04	188	134	5	b483b4629695764568bcbd1d527d614824147783
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECR TFPI2 ATP5MK F13B CHUK	2.61e-04	188	134	5	c1f64311ff05093b2f4f672e33f5f75e3bc8a8db
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TIGAR PSAP HLA-DQB1 CLEC7A CTSB	2.61e-04	188	134	5	f955f2eb92f399958d4d713e31af77d93fb4a6ec
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STAB2 MYCT1 EYS ART4 ST6GALNAC3	2.61e-04	188	134	5	2db80767903703e7e0a1a37c598f7877a909ee94
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CECR2 LAMA1 MFSD4A MALRD1 ABCA5	2.67e-04	189	134	5	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CECR2 LAMA1 MFSD4A ABCA5 SLC20A1	2.67e-04	189	134	5	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYCT1 DOCK9 STC1 ST6GALNAC3 CADPS2	2.67e-04	189	134	5	fe49852ba15f948b384d6b4c258927c70b741357
Drug	Ovta	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6	1.03e-06	14	132	4	CID003081047
Drug	AD 288	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6	1.03e-06	14	132	4	CID000073553
Drug	R165481	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6	1.86e-06	16	132	4	CID005459348
Drug	Antibiotic Ps 6	HIF1A RPS6KA4 RPS6KA5 GRM1 RPS6KA6	3.85e-06	41	132	5	CID000166290
Drug	K00085	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6	1.71e-05	27	132	4	CID009549283
Drug	AC1MS9WM	RPS6KA4 RPS6KA5 RPS6KA1 RPS6KA6	1.71e-05	27	132	4	CID003530978
Disease	Intellectual Disability	PECR LAMA1 TRMT1 L2HGDH GRIA1 HMGCL RABL6 NT5C2 PCYT2 CNDP1	3.04e-05	447	130	10	C3714756
Disease	Profound Mental Retardation	PECR LAMA1 TRMT1 L2HGDH RABL6 CNDP1	3.62e-05	139	130	6	C0020796
Disease	Mental Retardation, Psychosocial	PECR LAMA1 TRMT1 L2HGDH RABL6 CNDP1	3.62e-05	139	130	6	C0025363
Disease	Mental deficiency	PECR LAMA1 TRMT1 L2HGDH RABL6 CNDP1	3.62e-05	139	130	6	C0917816
Disease	Drusen, Radial, Autosomal Dominant	CFH CFI	5.76e-05	3	130	2	C1852021
Disease	Malattia Leventinese	CFH CFI	5.76e-05	3	130	2	C1852020
Disease	nuclear receptor coactivator 2 measurement	CFH IGHV3-43	5.76e-05	3	130	2	EFO_0801852
Disease	DOYNE HONEYCOMB RETINAL DYSTROPHY	CFH CFI	5.76e-05	3	130	2	C1832174
Disease	Coffin-Lowry syndrome (implicated_via_orthology)	RPS6KA1 RPS6KA6	1.15e-04	4	130	2	DOID:3783 (implicated_via_orthology)
Disease	EH domain-binding protein 1 measurement	CFH SLC19A2	1.15e-04	4	130	2	EFO_0801561
Disease	prostate and testis expressed protein 4 measurement	CFH PATE4	1.15e-04	4	130	2	EFO_0803301
Disease	E3 ubiquitin-protein ligase DTX1 measurement	CFH SLC19A2	1.15e-04	4	130	2	EFO_0802503
Disease	HELLP Syndrome	CFH CFI	1.15e-04	4	130	2	C0162739
Disease	brain measurement, hippocampal volume	ZNF326 MALRD1	2.86e-04	6	130	2	EFO_0004464, EFO_0005035
Disease	stromal cell-derived factor 1 measurement	CFH ABCA5	3.99e-04	7	130	2	EFO_0020756
Disease	Complement deficiency disease	CFH CFI MASP2	4.14e-04	33	130	3	C0272242
Disease	PAX-interacting protein 1 measurement	CFH HLA-DQB1	5.30e-04	8	130	2	EFO_0801868
Disease	leukocyte immunoglobulin-like receptor subfamily B member 4 measurement	PSAP CTSB	5.30e-04	8	130	2	EFO_0801768
Disease	gdnf family receptor alpha-1 measurement	CFH HLA-DQB1	5.30e-04	8	130	2	EFO_0020400
Disease	atypical hemolytic-uremic syndrome (is_implicated_in)	CFH CFI	5.30e-04	8	130	2	DOID:0080301 (is_implicated_in)
Disease	body mass index, age at assessment	TNNI3K TMEM18	5.30e-04	8	130	2	EFO_0004340, EFO_0008007
Disease	comparative body size at age 10, self-reported	ZNF536 GGNBP2 HLA-DQB1 TNNI3K TTBK1 PATJ ZC3H7B TMEM18	5.65e-04	420	130	8	EFO_0009819
Disease	risk-taking behaviour	GABRG3 ZNF536 FAM120B HLA-DQB1 GRIA1 TNNI3K TTBK1 CADPS2 PARPBP CTSB TMEM18	5.83e-04	764	130	11	EFO_0008579
Disease	feeling nervous measurement	HLA-DQB1 DNAH14 NT5C2 ZC3H7B	6.03e-04	87	130	4	EFO_0009597
Disease	zinc fingers and homeoboxes protein 3 measurement	CFH HLA-DQB1	6.80e-04	9	130	2	EFO_0803299
Disease	C3 glomerulopathy	CFH CFI	6.80e-04	9	130	2	C4087273
Disease	Atypical hemolytic-uremic syndrome	CFH CFI	6.80e-04	9	130	2	cv:C2931788
Disease	Hemolytic-uremic syndrome	CFH CFI	6.80e-04	9	130	2	cv:C0019061
Disease	HLA class II histocompatibility antigen, DQ alpha 2 chain measurement	CFH HLA-DQB1	6.80e-04	9	130	2	EFO_0801686
Disease	proteinuria (biomarker_via_orthology)	CFH HIF1A	8.47e-04	10	130	2	DOID:576 (biomarker_via_orthology)
Disease	Atypical Hemolytic Uremic Syndrome	CFH CFI	8.47e-04	10	130	2	C2931788
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement	CECR2 GNPNAT1 STC1	9.07e-04	43	130	3	EFO_0007788, EFO_0008343
Disease	psoriasis (is_marker_for)	CFH HIF1A CFI	9.70e-04	44	130	3	DOID:8893 (is_marker_for)
Disease	wet macular degeneration	CFH CFI	1.69e-03	14	130	2	EFO_0004683
Disease	C-C motif chemokine 19 measurement	CFH HLA-DQB1	1.69e-03	14	130	2	EFO_0008047
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	1.69e-03	14	130	2	DOID:3753 (implicated_via_orthology)
Disease	unipolar depression, response to escitalopram, response to citalopram, mood disorder	NT5C2 CSTF3	1.95e-03	15	130	2	EFO_0003761, EFO_0004247, EFO_0006329, EFO_0007871
Disease	hepatic encephalopathy (biomarker_via_orthology)	HIF1A GRIA1	1.95e-03	15	130	2	DOID:13413 (biomarker_via_orthology)
Disease	smoking behavior, body mass index	TNNI3K NT5C2 PATJ TMEM18	2.18e-03	123	130	4	EFO_0004318, EFO_0004340
Disease	sarcoidosis (is_implicated_in)	CFH HLA-DQB1	2.22e-03	16	130	2	DOID:11335 (is_implicated_in)
Disease	mosquito bite reaction size measurement	RAPGEF6 HLA-DQB1 ST6GALNAC3 CSTF3 PARPBP	2.53e-03	212	130	5	EFO_0008378
Disease	systemic lupus erythematosus (is_implicated_in)	CFH HLA-DQB1 CR2	2.61e-03	62	130	3	DOID:9074 (is_implicated_in)
Disease	nephrotic syndrome (is_marker_for)	CFI SERPINC1	2.81e-03	18	130	2	DOID:1184 (is_marker_for)
Disease	C-C motif chemokine 3 measurement	CFH GRIA1	2.81e-03	18	130	2	EFO_0008051
Disease	Age-related macular degeneration	CFH CFI	2.81e-03	18	130	2	cv:C0242383
Disease	Tourette syndrome, schizophrenia	ZNF536 GGNBP2	2.81e-03	18	130	2	EFO_0004895, MONDO_0005090
Disease	systemic lupus erythematosus	CFH TCF7 RPS6KA4 HLA-DQB1 TLR7 OLFML3 APIP NT5C2 ZPBP2 CTSB	2.89e-03	799	130	10	MONDO_0007915
Disease	acute lymphoblastic leukemia	TIGAR OR5AL1 ST6GALNAC3	3.12e-03	66	130	3	EFO_0000220
Disease	polycystic kidney disease (biomarker_via_orthology)	HIF1A CTSB	3.14e-03	19	130	2	DOID:0080322 (biomarker_via_orthology)
Disease	insomnia measurement	ZNF536 SLC25A20 ZPBP GRIA1 TNNI3K NT5C2 SERPINC1	3.56e-03	443	130	7	EFO_0007876
Disease	COVID-19 (is_implicated_in)	CFH TLR7	3.83e-03	21	130	2	DOID:0080600 (is_implicated_in)
Disease	Deep Vein Thrombosis	F13B SERPINC1	3.83e-03	21	130	2	C0149871
Disease	Venous Thrombosis	F13B SERPINC1	3.83e-03	21	130	2	C0042487
Disease	Idiopathic Pulmonary Fibrosis	HIF1A ABCA3	3.83e-03	21	130	2	C1800706
Disease	C-peptide measurement	HLA-DQB1 MUC19	4.20e-03	22	130	2	EFO_0005187
Disease	Henoch-Schoenlein purpura	HLA-DQB1 MALRD1	4.20e-03	22	130	2	EFO_1000965
Disease	serum IgM measurement	ODF1 ZPBP2	4.20e-03	22	130	2	EFO_0004993

Protein segments in the cluster

Peptide	Gene	Start	Entry
IGYRLSMYIDKYCAT	ABCA5	706	Q8WWZ7
IFSSMEYYSSCHKNR	ERV3-1	136	Q14264
NSVYTSFMKSHRCYD	PRKAG1	26	P54619
SKFYGNRFYEKEMEC	CFI	496	P05156
NFYNVDMSYLKRLCG	CTSB	46	P07858
IKCFGFDMDYTLAVY	NT5C2	46	P49902
EFMDYTSSQCGKYYS	AKIP1	91	Q9NQ31
CLGMAVSSFYENYET	ABCA3	1256	Q99758
YLTACMESLFRDIYS	BTBD11	236	A6QL63
GEQVTYTCATYYKMD	CFH	1011	P08603
YTCATYYKMDGASNV	CFH	1016	P08603
YYKMDGASNVTCINS	CFH	1021	P08603
FYKADGESCSASMMY	SERPINC1	271	P01008
VATFGKYDSELMCYA	CTBS	81	Q01459
KGDYYLCTETNFMNK	BCO2	186	Q9BYV7
MFRNCRKYNGESSEY	CECR2	506	Q9BXF3
YFNMRDSSDISRSCY	CHM	551	P24386
KEYGMDFYETSACTN	RAB15	141	P59190
CSTTAYFRGDKHMYS	PATE4	51	P0C8F1
YFRYAESSMKNSFGL	RABL6	206	Q3YEC7
NEKYDMVTDCGYTIS	OLFML3	126	Q9NRN5
LIRSQFACTYKDDYM	PARPBP	426	Q9NWS1
LGSTECFLYTVMSYD	OR10G7	106	Q8NGN6
LGSTECFLYTVMSYD	OR10G4	106	Q8NGN3
FLSDTGMACRSGKYY	NT5DC1	111	Q5TFE4
QRLMISDFSCVRYYG	EYS	1876	Q5T1H1
MLAYTEDSLQYKGCA	MFSD4A	421	Q8N468
RSCMTDAKKLYTLFY	GGNBP2	126	Q9H3C7
SYGVTEMYKACFLGA	L2HGDH	366	Q9H9P8
KFSYCDERITELMGY	HIF1A	251	Q16665
VRGCDSYMVYLFDKS	CHUK	376	O15111
KKYFNSYTLTGRMNC	ATP5MK	16	Q96IX5
QENMRYGCASGYKTT	F13B	111	P05160
MSSEYREYADSFGKC	PCYT2	166	Q99447
KIVRMCAGDSEFYSY	PLXNA3	261	P51805
KYLGFCTAVAMYAEA	MUC19	1506	Q7Z5P9
STQGMYKYLERCFSD	PGM2L1	91	Q6PCE3
NLTGTFYMCKAVYSS	PECR	131	Q9BY49
DRYKFMDLYPCSASE	CSTF3	526	Q12996
MYSGTFDCFRKTLFR	SLC25A20	51	O43772
EGKEITCRSYLMTNY	GGCT	116	O75223
KCYLAYTTFISGSAM	KCNU1	381	A8MYU2
KERTFSFCGTIEYMA	RPS6KA4	191	O75676
ETERAYSFCGTIEYM	RPS6KA5	206	O75582
QEKKAYSFCGTVEYM	RPS6KA6	226	Q9UK32
NRYDCLGSKKYSYMN	ODF1	156	Q14990
STEFFLLASMSYDCY	OR6C76	106	A6NM76
VGYSYSCMALRDSEV	DMPK	401	Q09013
QMNSLRTEDTALYYC	IGHV3-43	101	A0A0B4J1X8
FLGTAECYLLSSMAY	OR8H3	106	Q8N146
KLSCSDTSLYKIFMY	OR2T10	186	Q8NGZ9
TDTKGCTFRFYYHMF	MALRD1	936	Q5VYJ5
TTECFLLAAMAYDRY	OR5T1	121	Q8NG75
MSCSKAYGERYVASV	RGPD3	1	A6NKT7
YQFKAMCYFTNGTER	HLA-DQB1	41	P01920
HMERCYAKYESQTSF	CXXC1	501	Q9P0U4
GETAMVTADSKYCYG	FKBP8	166	Q14318
DYTCYAQNTLGKDEM	IGSF10	2116	Q6WRI0
KDRYTYNDTVIFACM	CR2	366	P20023
YKFPSTFYEGRADMC	DOCK9	1461	Q9BZ29
MTSDCDIYQTLRGYA	GCNT4	106	Q9P109
LMEYATLNYYSSCRK	GABRG3	331	Q99928
SMCTAIAGYFDIYFE	PRMT3	446	O60678
YQYSSYLSSCCKGMV	AXDND1	756	Q5T1B0
DKVYSSVLRQCYSMY	CCZ1	131	P86791
KGADYMDCLYRYLNT	CUL2	96	Q13617
DKVYSSVLRQCYSMY	CCZ1B	131	P86790
NTYGERFCYLLMSAS	DPY19L4	241	Q7Z388
SQYTFAMCSYREKKS	CADPS2	516	Q86UW7
MFYNDCVKSFVSSYS	DNAH14	1021	Q0VDD8
MESFFLSETCKYLYL	EDEM1	546	Q92611
CEETFYTMKVNDGKY	MASP2	396	O00187
KKFGYTVSEENYMCR	GNPNAT1	166	Q96EK6
DSFEMTYRFCSQFSK	GRIA1	66	P42261
GLLIMSCTYYAFKTR	GRM1	761	Q13255
YSDLASLACMSKYSA	SEC24B	871	O95487
VNEFCERFSYYGMKA	SLC15A2	51	Q16348
LGMYQKVTSYCRSAT	SLC19A2	151	O60779
KKRIRMDSYTSYCNA	SLC20A1	456	Q8WUM9
EGMFESFRYKCLSSY	FAM120B	236	Q96EK7
NYLEGSQKDCYRDTM	KRBA2	51	Q6ZNG9
YMTYASQETFGCLES	MAP1LC3C	116	Q9BXW4
LGSTECFLYTVMSYD	OR10G9	106	Q8NGN4
AESFMSYGLCRTEKF	MOXD2P	356	A6NHM9
KCTSGGYYRYDDMLV	APIP	146	Q96GX9
MDYYGTRLATCSSDR	SEC13	21	P55735
YSGKTTLCNMLAENY	AK9	401	Q5TCS8
MSCSKAYGERYVASV	RGPD4	1	Q7Z3J3
ETCYSKYGAMALKSR	TRMT1	271	Q9NXH9
YMRSLFDYFLTDLKC	TIGAR	201	Q9NQ88
GRYYLKNNMETETLC	RAPGEF6	826	Q8TEU7
CVYMKNVYGGTDSDT	PPP1R3C	201	Q9UQK1
MRTQVYEGLCKNYFS	MYCT1	1	Q8N699
MCALKGFLEENFYTY	OR5AL1	1	P0C617
KFYSMGCYEISLGDT	HMGCL	191	P35914
RYYYSIKDISVGGMC	LAMA1	256	P25391
FSEFYYCTEDVLRMG	ENTPD4	431	Q9Y227
TMSCSEGFKNLFYRT	SLC46A3	231	Q7Z3Q1
MSEASRLCSGYYSLN	SHISAL2B	1	A6NKW6
YVTTEKRMSYCDGVF	ST6GALNAC3	186	Q8NDV1
HVALFKMYTSSDCRY	PGAP1	561	Q75T13
GGKNYSEMYVTCARD	RGN	251	Q15493
YVCTTRNASYCDKMS	IL1R2	106	P27930
DTDGMYDICKSFLYS	STC1	66	P52823
YTRLTHMETDNKCFY	B4GALNT4	376	Q76KP1
NVKATFYGLYSMSCD	CIDEB	151	Q9UHD4
IYEKSCYLFSMSLNS	CLEC7A	126	Q9BXN2
YGTRGNSYFMVEVKC	CNDP1	241	Q96KN2
KCYMLDFGLARQYTN	TTBK1	171	Q5TCY1
YTGMLSSRYATDTCE	PATJ	1031	Q8NI35
GNEKRRCIYTSYFMG	STAB2	1301	Q8WWQ8
YMRLTGTAIDCYKYL	PRPF38A	106	Q8NAV1
CKVYSSFQSLMSECY	PKD2L2	141	Q9NZM6
SFQSLMSECYGKYTS	PKD2L2	146	Q9NZM6
MSECYGKYTSANEDL	PKD2L2	151	Q9NZM6
GMADICKNYISQYSE	PSAP	236	P07602
EASFMSVNESCYKYG	TLR7	481	Q9NYK1
MSNKQYYDALCSGEI	TMOD4	141	Q9NZQ9
ECTSGMYKETVYSAF	TCF7	111	P36402
EESMSGIYTCFLEYK	ZPBP	131	Q9BS86
GSLYAEMTENKYVCF	TMEM262	71	E9PQX1
LYSRYLSCLQSGFMT	ZNF536	426	O15090
FSMYTGLIYNDCFSK	ATP6V0A1	456	Q93050
CGKTFYYNSSLTRHM	ZNF80	166	P51504
CEGSTEKYFFNLSSM	TFPI2	106	P48307
LYEECVRMNDGFSSY	TRMT10B	176	Q6PF06
CAVSYTTQAGEKMYF	TRAPPC13	146	A5PLN9
RYRANTYCSKSDVDM	TNNI3K	491	Q59H18
LYSCKYCDFRSHDMT	ZHX3	76	Q9H4I2
RLVSTMSKYYNDCYA	PICK1	336	Q9NRD5
SFTSIMGYLYHVRKC	ZNF512	261	Q96ME7
SKYQYFDSRGMFISI	TMEM18	81	Q96B42
KYFDRASYRVFCLMS	TKTL1	111	P51854
DYSYQMAVRFTTRSC	ZPBP2	141	Q6X784
VNRAACYFTMGLYEK	ZC3H7B	86	Q9UGR2
CYFTMGLYEKALEDS	ZC3H7B	91	Q9UGR2
TSFVGSYYLCKDMIN	ZC3H7B	476	Q9UGR2
SEKYGDGYRMAFTCS	ZNF326	301	Q5BKZ1
EKKAYSFCGTVEYMA	RPS6KA1	216	Q15418
MENGTLCYEVHYRTK	ART4	176	Q93070
YYFRVFSENMCGLSE	MYBPC1	1001	Q00872
LDYTIKCYESFMSGA	NDC80	226	O14777