Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine phosphatase activity	PTPRA PTPRD PTPRF PTPRZ1	2.83e-07	17	68	4	GO:0005001
GeneOntologyMolecularFunction	transmembrane receptor protein phosphatase activity	PTPRA PTPRD PTPRF PTPRZ1	2.83e-07	17	68	4	GO:0019198
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	ENPP7 PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1 PON3 GNAQ NT5DC3	6.95e-07	386	68	10	GO:0042578
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	1.37e-06	103	68	6	GO:0004725
GeneOntologyMolecularFunction	phosphatase activity	ENPP7 PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1 NT5DC3	5.79e-06	287	68	8	GO:0016791
GeneOntologyMolecularFunction	phosphoprotein phosphatase activity	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	4.47e-05	189	68	6	GO:0004721
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	ENPP7 PTPRA ARSB PTPRD PTPRF PTPRS PTPRZ1 DUSP1 PON3 GNAQ NT5DC3	8.19e-05	807	68	11	GO:0016788
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX9 ZNF560 YLPM1 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	8.44e-04	1412	68	13	GO:0000981
GeneOntologyBiologicalProcess	peptidyl-tyrosine dephosphorylation	PTPRF PTPRS PTPRZ1 DUSP1	4.38e-06	34	67	4	GO:0035335
GeneOntologyCellularComponent	postsynaptic density membrane	PTPRF PTPRS PTPRZ1 DLG2 ADCY1	1.49e-04	157	67	5	GO:0098839
GeneOntologyCellularComponent	dendrite	CNNM4 KCNE3 IFT52 PTPRZ1 DYRK1A DLG2 SPG11 TACR1 GNAQ TXNRD2	3.83e-04	858	67	10	GO:0030425
GeneOntologyCellularComponent	dendritic tree	CNNM4 KCNE3 IFT52 PTPRZ1 DYRK1A DLG2 SPG11 TACR1 GNAQ TXNRD2	3.90e-04	860	67	10	GO:0097447
GeneOntologyCellularComponent	postsynaptic specialization membrane	PTPRF PTPRS PTPRZ1 DLG2 ADCY1	4.66e-04	201	67	5	GO:0099634
GeneOntologyCellularComponent	somatodendritic compartment	CNNM4 KCNE3 IFT52 PTPRF PTPRS PTPRZ1 DYRK1A DLG2 SPG11 TACR1 GNAQ TXNRD2	4.75e-04	1228	67	12	GO:0036477
Domain	PTPc_motif	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	6.58e-08	59	67	6	SM00404
Domain	Tyr_Pase_cat	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	6.58e-08	59	67	6	IPR003595
Domain	PTPc	PTPRA PTPRD PTPRF PTPRS PTPRZ1	1.77e-07	36	67	5	SM00194
Domain	Tyr_Pase_AS	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	2.39e-07	73	67	6	IPR016130
Domain	TYR_PHOSPHATASE_PTP	PTPRA PTPRD PTPRF PTPRS PTPRZ1	2.67e-07	39	67	5	PS50055
Domain	PTPase_domain	PTPRA PTPRD PTPRF PTPRS PTPRZ1	3.46e-07	41	67	5	IPR000242
Domain	Y_phosphatase	PTPRA PTPRD PTPRF PTPRS PTPRZ1	3.46e-07	41	67	5	PF00102
Domain	TYR_PHOSPHATASE_1	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	6.37e-07	86	67	6	PS00383
Domain	TYR_PHOSPHATASE_2	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	6.82e-07	87	67	6	PS50056
Domain	TYR_PHOSPHATASE_dom	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	6.82e-07	87	67	6	IPR000387
Domain	-	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	9.49e-07	92	67	6	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1	1.46e-06	99	67	6	IPR029021
Domain	-	ZNF462 ZNF560 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	4.64e-06	679	67	12	3.30.160.60
Domain	zf-C2H2	ZNF462 ZNF560 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	5.71e-06	693	67	12	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF462 ZNF560 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	5.79e-06	694	67	12	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF462 ZNF560 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	1.76e-05	775	67	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF462 ZNF560 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	1.80e-05	777	67	12	PS00028
Domain	Znf_C2H2-like	ZNF462 ZNF560 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	2.29e-05	796	67	12	IPR015880
Domain	Znf_C2H2	ZNF462 ZNF560 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	2.56e-05	805	67	12	IPR007087
Domain	ZnF_C2H2	ZNF462 ZNF560 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	2.65e-05	808	67	12	SM00355
Domain	KRAB	ZNF560 ZNF790 ZNF30 ZNF782 ZNF582 ZNF563 ZNF445	2.90e-04	358	67	7	PS50805
Domain	KRAB	ZNF560 ZNF790 ZNF30 ZNF782 ZNF582 ZNF563 ZNF445	2.90e-04	358	67	7	PF01352
Domain	KRAB	ZNF560 ZNF790 ZNF30 ZNF782 ZNF582 ZNF563 ZNF445	3.49e-04	369	67	7	SM00349
Domain	KRAB	ZNF560 ZNF790 ZNF30 ZNF782 ZNF582 ZNF563 ZNF445	3.54e-04	370	67	7	IPR001909
Domain	zf-C2H2_6	ZNF560 ZNF790 ZNF30 ZNF782 ZNF582 ZNF445	9.08e-04	314	67	6	PF13912
Domain	fn3	PTPRD PTPRF PTPRS PTPRZ1	2.73e-03	162	67	4	PF00041
Domain	FN3	PTPRD PTPRF PTPRS PTPRZ1	4.39e-03	185	67	4	SM00060
Domain	Alkaline_phosphatase_core	ENPP7 ARSB	5.51e-03	31	67	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ENPP7 ARSB	5.51e-03	31	67	2	IPR017849
Domain	-	ENPP7 ARSB	5.51e-03	31	67	2	3.40.720.10
Domain	FN3	PTPRD PTPRF PTPRS PTPRZ1	5.68e-03	199	67	4	PS50853
Domain	FN3_dom	PTPRD PTPRF PTPRS PTPRZ1	6.74e-03	209	67	4	IPR003961
Pathway	REACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES	PTPRD PTPRF PTPRS	4.87e-05	20	51	3	M27290
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	PTPRD PTPRF PTPRS	4.87e-05	20	51	3	MM15485
Pathway	REACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES	PTPRD PTPRF PTPRS	4.87e-05	20	51	3	MM14991
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	PTPRD PTPRF PTPRS	5.67e-05	21	51	3	M27736
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	PTPRD PTPRF PTPRS DLG2	9.84e-05	67	51	4	MM15327
Pathway	WP_T_CELL_RECEPTOR_AND_COSTIMULATORY_SIGNALING	CSNK1A1 DYRK1A ITK	1.37e-04	28	51	3	M39632
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	PTPRD PTPRF PTPRS DLG2	2.71e-04	87	51	4	M27617
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	CAMKK2 GNAQ ADCY1	3.72e-04	39	51	3	MM14496
Pathway	WP_SPINAL_CORD_INJURY	SOX9 PTPRA PTPRZ1 TACR1	6.17e-04	108	51	4	MM15954
Pubmed	Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs.	PTPRA PTPRD PTPRF PTPRS	6.67e-11	5	68	4	10777529
Pubmed	Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.	PTPRA PTPRD PTPRF PTPRS	4.66e-10	7	68	4	12376545
Pubmed	A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.	PTPRA PTPRD PTPRF PTPRS	4.36e-09	11	68	4	7832766
Pubmed	LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.	PTPRD PTPRF PTPRS	7.15e-09	3	68	3	31985401
Pubmed	Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.	PTPRD PTPRF PTPRS	7.15e-09	3	68	3	20139422
Pubmed	Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.	PTPRD PTPRF PTPRS	7.15e-09	3	68	3	9784606
Pubmed	Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.	PTPRD PTPRF PTPRS	7.15e-09	3	68	3	33656439
Pubmed	The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.	PTPRD PTPRF PTPRS	2.86e-08	4	68	3	8524829
Pubmed	Protein tyrosine phosphatases expression during development of mouse superior colliculus.	PTPRA PTPRD PTPRF PTPRS	3.12e-08	17	68	4	19727691
Pubmed	Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.	PTPRD PTPRF PTPRS	7.13e-08	5	68	3	22357843
Pubmed	Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases.	PTPRD PTPRF PTPRS	1.42e-07	6	68	3	19273906
Pubmed	Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.	PTPRA PTPRD PTPRZ1	1.42e-07	6	68	3	2170109
Pubmed	Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.	PTPRA PTPRD PTPRF PTPRS	1.93e-07	26	68	4	36178190
Pubmed	Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.	PTPRD PTPRF PTPRS	2.49e-07	7	68	3	29073098
Pubmed	Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain.	PTPRA PTPRF PTPRS	2.49e-07	7	68	3	1454056
Pubmed	Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.	PTPRD PTPRF PTPRS	3.98e-07	8	68	3	37591863
Pubmed	Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.	PTPRD PTPRF PTPRS	3.98e-07	8	68	3	28637841
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF462 CNNM4 PTPRS CSNK1A1 VPS13C SIPA1L3 HECTD4 LAMA3 GRB10 TTC17 USP3 ADCY1 SNX29 CCNY	9.21e-07	1489	68	14	28611215
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SOX9 PTPRA PTPRD SIPA1L3 YLPM1 HECTD4 DYRK1A SENP6 DLG2 ZNF76 TTC17 ZNFX1 ZNF292	1.07e-06	1285	68	13	35914814
Pubmed	PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.	PTPRD PTPRF PTPRS	1.17e-06	11	68	3	25624497
Pubmed	Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder.	PTPRA PTPRD PTPRS	1.55e-06	12	68	3	31875546
Pubmed	Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.	PTPRD PTPRF PTPRS	1.55e-06	12	68	3	9624153
Pubmed	Tolerance Biomarkers in Liver Transplantation: Independent External Validation of the Predictive Strength of SENP6 and FEM1C Gene Expression.	SENP6 FEM1C	3.77e-06	2	68	2	30720688
Pubmed	LAR tyrosine phosphatase receptor: proximal membrane alternative splicing is coordinated with regional expression and intraneuronal localization.	PTPRA PTPRF	3.77e-06	2	68	2	9748473
Pubmed	Protein tyrosine-phosphatase expression profiling in gastric cancer tissues.	PTPRA PTPRZ1	3.77e-06	2	68	2	16338072
Pubmed	Expression of protein-tyrosine phosphatases in the major insulin target tissues.	PTPRA PTPRS	3.77e-06	2	68	2	9357975
Pubmed	The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization.	PTPRD PTPRF	3.77e-06	2	68	2	7665159
Pubmed	The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma.	PTPRD PTPRS	3.77e-06	2	68	2	9566880
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CNNM4 PTPRA PTPRD PTPRF PTPRS PTPRZ1 DUSP1 SIPA1L3 YLPM1 NOC4L NAA50	5.68e-06	1049	68	11	27880917
Pubmed	Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway.	PTPRD PTPRF	1.13e-05	3	68	2	25703008
Pubmed	Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation.	TACR1 GNAQ	1.13e-05	3	68	2	17895403
Pubmed	Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion.	PTPRD PTPRS	1.13e-05	3	68	2	25394468
Pubmed	Leukocyte antigen-related deficiency enhances insulin-like growth factor-1 signaling in vascular smooth muscle cells and promotes neointima formation in response to vascular injury.	PTPRA PTPRF	1.13e-05	3	68	2	17500057
Pubmed	Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.	CSNK1A1 DYRK1A	1.13e-05	3	68	2	16959772
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	VPS13C BEND7 ISCU ZNFX1 NEB	1.25e-05	152	68	5	34299191
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ZNF462 PTPRD PTPRS CSNK1A1 SIPA1L3 YLPM1 HECTD4 DYRK1A DLG2 ZNFX1	1.72e-05	963	68	10	28671696
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	CNNM4 NCAPD3 PTPRA PTPRD PTPRF PTPRS CSNK1A1 DUSP1 TTC17 ASCC3	1.89e-05	974	68	10	28675297
Pubmed	Dynamic changes in the expression of protein tyrosine phosphatases during preimplantation mouse development: semi-quantification by real-time PCR.	PTPRF PTPRS	2.25e-05	4	68	2	14967925
Pubmed	Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.	PTPRF PTPRS	2.25e-05	4	68	2	26231120
Pubmed	The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74.	PTPRS PTPRZ1	2.25e-05	4	68	2	22140262
Pubmed	Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection.	PTPRS CAPSL USP3	3.40e-05	32	68	3	14613977
Pubmed	Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.	PTPRA PTPRZ1	3.75e-05	5	68	2	2169617
Pubmed	Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons.	PTPRD PTPRS	5.62e-05	6	68	2	38388459
Pubmed	Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta.	PTPRD PTPRS	5.62e-05	6	68	2	16738228
Pubmed	Receptor protein tyrosine phosphatases are novel components of a polycystin complex.	PTPRD PTPRS	5.62e-05	6	68	2	21126580
Pubmed	Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.	PTPRF PTPRZ1	7.86e-05	7	68	2	21976490
Pubmed	Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases.	PTPRD PTPRS	7.86e-05	7	68	2	23345436
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NCAPD3 CAMKK2 VPS13C HECTD4 SENP6 SPG11 FEM1C	7.87e-05	529	68	7	14621295
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	CNNM4 PTPRA PTPRF PTPRS CSNK1G3 DLG2	9.69e-05	377	68	6	38117590
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PTPRA PTPRS PTPRZ1 CSNK1A1 SIPA1L3 DYRK1A DLG2 ZNFX1 GNAQ NT5DC3 DNAH6	9.77e-05	1431	68	11	37142655
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	ZNF462 SOX9 PTPRD PTPRS PTPRZ1	1.35e-04	251	68	5	29031500
Pubmed	Neural conditional ablation of the protein tyrosine phosphatase receptor Delta PTPRD impairs gliogenesis in the developing mouse brain cortex.	SOX9 PTPRD	1.68e-04	10	68	2	38487272
Pubmed	Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.	CSNK1A1 CSNK1G3	1.68e-04	10	68	2	25500533
Pubmed	Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.	CSNK1A1 HECTD4	2.05e-04	11	68	2	21642993
Pubmed	Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex.	CSNK1A1 DYRK1A	2.05e-04	11	68	2	21709260
Pubmed	Proteomic and functional evidence for a P2X7 receptor signalling complex.	PTPRZ1 LAMA3	2.05e-04	11	68	2	11707406
Pubmed	Sulfation of Glycosaminoglycans Modulates the Cell Cycle of Embryonic Mouse Spinal Cord Neural Stem Cells.	PTPRF PTPRZ1	2.45e-04	12	68	2	34169071
Pubmed	Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome.	SOX9 DYRK1A	2.45e-04	12	68	2	36402907
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	PTPRA PTPRD PTPRF PTPRS	2.93e-04	162	68	4	25826454
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	CSNK1A1 YLPM1 DYRK1A NOC4L NAA50	3.18e-04	302	68	5	30561431
Pubmed	Mechanism of GTP hydrolysis by G-protein alpha subunits.	GNAQ ADCY1	3.89e-04	15	68	2	7937899
Pubmed	Association of CPI-17 with protein kinase C and casein kinase I.	CSNK1A1 CSNK1G3	3.89e-04	15	68	2	15003508
Pubmed	Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.	PTPRF PTPRS	3.89e-04	15	68	2	23863482
Pubmed	Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.	PTPRA PTPRF	4.44e-04	16	68	2	8875997
Pubmed	Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina.	PTPRS PTPRZ1	4.44e-04	16	68	2	18308476
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	CSNK1A1 DYRK1A ITK	4.90e-04	78	68	3	17192257
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	PTPRD VPS13C	5.65e-04	18	68	2	27984743
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	NCAPD3 TTC17 ZNFX1 ASCC3	6.73e-04	202	68	4	33005030
Pubmed	A novel common variant in DCST2 is associated with length in early life and height in adulthood.	TTC17 ZNFX1	7.00e-04	20	68	2	25281659
Pubmed	Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.	PTPRF LAMA3	7.72e-04	21	68	2	22959728
Pubmed	Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.	SOX9 ARSB	7.72e-04	21	68	2	26234751
Pubmed	Temporomandibular joint formation requires two distinct hedgehog-dependent steps.	SOX9 ZNF445	7.72e-04	21	68	2	19815519
Pubmed	m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina.	SOX9 ZNF292	8.48e-04	22	68	2	36459087
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ZNF462 NCAPD3 CSNK1A1 SENP6	9.56e-04	222	68	4	37071664
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF462 ZNF790 ZNF322 ZNF76 ZNF623 ZNF292 ZNF445	1.01e-03	808	68	7	20412781
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	SIPA1L3 ISCU DYRK1A	1.07e-03	102	68	3	15778465
Pubmed	The human (PEDB) and mouse (mPEDB) Prostate Expression Databases.	MRPS10 KCNE3 NEB	1.19e-03	106	68	3	11752298
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF462 SPG11 FEM1C	1.23e-03	107	68	3	11347906
Pubmed	Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.	NEB ITK	1.38e-03	28	68	2	18067320
Pubmed	Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome.	SOX9 DYRK1A	1.48e-03	29	68	2	23843306
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	PTPRF PTPRS PTPRZ1 PON3	1.64e-03	257	68	4	16335952
Pubmed	Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.	VPS13C DLG2	1.91e-03	33	68	2	25064009
Interaction	OMG interactions	PTPRD PTPRF PTPRS	9.37e-06	13	66	3	int:OMG
Interaction	PTPRF interactions	KCNE3 PTPRA PTPRD PTPRF PTPRS PTPRZ1 NAA50	1.10e-05	233	66	7	int:PTPRF
Interaction	PTPRA interactions	KCNE3 PTPRA PTPRD PTPRF PTPRS PTPRZ1	1.61e-05	164	66	6	int:PTPRA
Interaction	CSNK1G2 interactions	KCNE3 PTPRF PTPRS CSNK1G3 HECTD4	4.42e-05	119	66	5	int:CSNK1G2
Interaction	DNAJC7 interactions	NUDT19 CAMKK2 KCNE3 VPS13C DYRK1A SPG11 NAA50 ASCC3	7.22e-05	425	66	8	int:DNAJC7
Interaction	PTPRQ interactions	PTPRA PTPRF PTPRS	7.33e-05	25	66	3	int:PTPRQ
Interaction	MARCHF1 interactions	PTPRA PTPRF PTPRS CSNK1G3	8.18e-05	70	66	4	int:MARCHF1
Cytoband	19q13.11	NUDT19 ZNF30	2.05e-03	45	68	2	19q13.11
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRA PTPRD PTPRF PTPRS PTPRZ1	2.87e-09	21	51	5	813
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 ZNF560 ZNF790 ZNF322 ZNF76 ZNF30 ZNF782 ZNF623 ZNF582 ZNF292 ZNF563 ZNF445	5.36e-07	718	51	12	28
GeneFamily	Fibronectin type III domain containing	PTPRD PTPRF PTPRS PTPRZ1	1.07e-03	160	51	4	555
Coexpression	FINETTI_BREAST_CANCERS_KINOME_GRAY	CSNK1A1 CSNK1G3 DYRK1A	7.43e-06	15	68	3	M9693
Coexpression	GSE5589_WT_VS_IL10_KO_LPS_STIM_MACROPHAGE_45MIN_DN	NUDT19 CSNK1A1 SENP6 PON3 TTC17 ZNF623	1.31e-05	199	68	6	M6648
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	FNIP2 PTPRZ1 YLPM1 DYRK1A SENP6 ZNF322 FEM1C CCNY ZNF292 ZNF445	1.86e-05	595	68	10	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
Disease	Attention deficit hyperactivity disorder	PTPRD TACR1 ZNF292	1.91e-05	24	64	3	C1263846
Disease	azoospermia (implicated_via_orthology)	PTPRD PTPRF PTPRS	2.74e-05	27	64	3	DOID:14227 (implicated_via_orthology)
Disease	thyroxine measurement	BEND7 LAMA3 USP3 SNX29	3.25e-05	83	64	4	EFO_0005130
Disease	putamen volume	GRB10 DLG2 ASCC3	4.19e-05	31	64	3	EFO_0006932
Disease	Modic type vertebral endplate changes	PTPRD DLG2	3.56e-04	13	64	2	HP_0030775
Disease	phoneme awareness	DYRK1A ZNFX1	4.14e-04	14	64	2	EFO_0021812
Disease	serum gamma-glutamyl transferase measurement	CAMKK2 CSNK1G3 SIPA1L3 HECTD4 DYRK1A USP3 ITK ZNF292	7.85e-04	914	64	8	EFO_0004532
Disease	health study participation	FNIP2 PTPRF DLG2 ASCC3	8.62e-04	195	64	4	EFO_0010130
Disease	Attention Deficit Disorder	PTPRD TACR1	1.04e-03	22	64	2	C0041671
Disease	Minimal Brain Dysfunction	PTPRD TACR1	1.04e-03	22	64	2	C1321905
Disease	C-reactive protein measurement	CAMKK2 ARSB PTPRF VPS13C DUSP1 CAPSL DYRK1A SPG11 USP3	1.13e-03	1206	64	9	EFO_0004458
Disease	waist-hip ratio	CAMKK2 PTPRD PTPRS DUSP1 HECTD4 GRB10 DLG2 USP3 IQUB	1.26e-03	1226	64	9	EFO_0004343
Disease	osteoarthritis	NUDT19 SENP6 DLG2 ZNF623	1.39e-03	222	64	4	MONDO_0005178
Disease	gastric adenocarcinoma (is_marker_for)	PTPRA PTPRZ1	1.69e-03	28	64	2	DOID:3717 (is_marker_for)
Disease	age at menarche	ZNF462 PTPRD SENP6 DLG2 GNAQ ASCC3	1.81e-03	594	64	6	EFO_0004703
Disease	pulmonary tuberculosis	LAMA3 CCNY	1.81e-03	29	64	2	EFO_1000049
Disease	esophageal carcinoma	CSNK1A1 HECTD4	1.94e-03	30	64	2	EFO_0002916
Disease	Alzheimer disease, educational attainment	FNIP2 PTPRF DLG2 SNX29	2.05e-03	247	64	4	EFO_0011015, MONDO_0004975
Disease	blood viscosity	PTPRD PTPRF	2.07e-03	31	64	2	EFO_0004301

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVHYEGRHIQYAKIS	ADAD1	196	Q96M93
YDKHNPEQKQIYRFV	CCNY	161	Q8ND76
HINEVYYAKKKRRHQ	DYRK1A	106	Q13627
YKYEHNKAHAQLVRE	GNAQ	101	P50148
PARLYHKKVVDHYEN	ISCU	31	Q9H1K1
NHRIYYKGHIPEKLE	FEM1C	596	Q96JP0
VVPAENYDYQILHKK	LAMA3	1206	Q16787
DIHVTVQPKYKHVYP	NUDT19	351	A8MXV4
DKRSDPYHVYIKNRV	KCNE3	86	Q9Y6H6
KNYYKRIEPADAHVL	NAA50	136	Q9GZZ1
KHKNRYINIVAYDHS	PTPRZ1	1751	P23471
HPVRDNYKFKETVHI	HECTD4	641	Q9Y4D8
EYVHSKNLIYRDVKP	CSNK1G3	151	Q9Y6M4
NKPKNRYANVIAYDH	PTPRS	1416	Q13332
VHYDPEKDVHIYEAQ	METTL21A	196	Q8WXB1
KYKHVEREQKYHQLQ	ADCY1	591	Q08828
YQDHKQPEYIHEQNR	DNAH6	81	Q9C0G6
VRNVYHKYFHPKEAL	IFT52	116	Q9Y366
LREVYNAKHHPKYQN	CAPSL	136	Q8WWF8
GHYQYKSIPVEDNHK	DUSP1	216	P28562
SHHAKEQLPKYQYTR	FNIP2	116	Q9P278
RQVSYTPQHHEKQYA	IQUB	86	Q8NA54
YLKPYDFIQDKNRHH	ARSB	251	P15848
EYLHYQKIIHRDIKP	CAMKK2	301	Q96RR4
LHHPYYQDKVEQTPR	GRB10	11	Q13322
KLVSRDYHHEVYKIP	BEND7	16	Q8N7W2
TNVKKYRYQDEDAPH	DLG2	11	Q15700
VYDALKDAHPKLHVY	ENPP7	296	Q6UWV6
TPQKHKRISHYEKEY	SLC17A5	251	Q9NRA2
IHKHNLEYPDFYRKL	NOC4L	316	Q9BVI4
KEKNRYVNILPYDHS	PTPRA	266	P18433
KPKNRYANVIAYDHS	PTPRF	1376	P10586
KPKNRYANVIAYDHS	PTPRD	1381	P23468
KHYHIKETNDNPKRY	ITK	291	Q08881
YYLKLHEKHPEIVFQ	GARIN1A	151	Q6NXP2
LQSVHIYKKHRVQYE	MRPS10	121	P82664
LHHKLQNKYPQVRAY	SNX29	701	Q8TEQ0
KNNIDYEPVHLYKDV	NT5DC3	236	Q86UY8
YVHTKNFIHRDIKPD	CSNK1A1	126	P48729
EHPNKIYEKVYHICV	TACR1	186	P25103
EDHKEHGPQYQYRII	SIPA1L3	536	O60292
LRVQHKKDHPDYKYQ	SOX9	161	P48436
DVEKIHYPHVYDSQA	ASCC3	396	Q8N3C0
HKKNVSVQYREYGLH	NCAPD3	101	P42695
QELKFDEHNKYYARH	CNNM4	586	Q6P4Q7
HNYHPAEVKSLIQYF	SPG11	1381	Q96JI7
HQRLHVGEKPYKYEK	ZNF30	166	P17039
YLVQHQRIHTGEKPY	ZNF30	526	P17039
IVRHAQKHYKDGIYS	ZNF292	556	O60281
LTSHQRIHNYEKPYK	ZNF322	86	Q6U7Q0
HLKKAVRYNDYIQPI	TMPRSS12	176	Q86WS5
YEPNPHYHENAVIQK	SENP6	781	Q9GZR1
ENHIKKLEGETYRYH	VPS13C	3621	Q709C8
DKDNTVYLYVVNHPH	PON3	121	Q15166
ELKEYQKQHDHYLRQ	TTC17	361	Q96AE7
LHSYPHKDQLQEYEK	YLPM1	466	P49750
HIYQDLENHPSVLKY	ZNFX1	1086	Q9P2E3
HQVIHTEKKPYEYKE	ZNF582	441	Q96NG8
RYVNGHAKKHYEDAQ	USP3	51	Q9Y6I4
HEYQEYGEKPHTHKQ	ZNF563	131	Q8TA94
YVLEHQRIHTQEKPY	ZNF445	611	P59923
QEHVEVYHAHYKPLE	TXNRD2	421	Q9NNW7
YLAQHEKIHNERKSY	ZNF790	436	Q6PG37
LVHYQKKHPEEKASY	ZNF462	1046	Q96JM2
KLKIHYEKYHNQPEF	ZNF462	1591	Q96JM2
HQKVHIRAKPYEYNE	ZNF782	356	Q6ZMW2
HYQIHTEVKQYECKE	ZNF623	281	O75123
NYKNHVRIHTGEKPY	ZNF76	301	P36508
LRVHNGEKPYEHKEY	ZNF560	451	Q96MR9
LNYRKHYEDTKANVH	NEB	4531	P20929
QKHLASHIKYREEYE	NEB	4731	P20929