Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmicrotubule motor activity

KIF21B KIF4A KIF4B KIF2B

3.08e-0670294GO:0003777
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

PGA4 PGA5 PGA3

2.07e-0537293GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

PGA4 PGA5 PGA3

2.25e-0538293GO:0070001
GeneOntologyMolecularFunctioncytoskeletal motor activity

KIF21B KIF4A KIF4B KIF2B

2.46e-05118294GO:0003774
GeneOntologyMolecularFunctioncullin family protein binding

KLHL9 KLHL13

6.48e-0426292GO:0097602
GeneOntologyMolecularFunctionmicrotubule binding

KIF21B KIF4A KIF4B KIF2B

9.72e-04308294GO:0008017
GeneOntologyBiologicalProcessmitotic spindle midzone assembly

KIF4A KIF4B

9.01e-0511272GO:0051256
GeneOntologyBiologicalProcessmitotic spindle elongation

KIF4A KIF4B

1.08e-0412272GO:0000022
GeneOntologyBiologicalProcesscytokinesis

KIF4A KIF4B KLHL9 KLHL13

1.36e-04204274GO:0000910
GeneOntologyBiologicalProcessspindle midzone assembly

KIF4A KIF4B

1.49e-0414272GO:0051255
GeneOntologyBiologicalProcessspindle elongation

KIF4A KIF4B

1.49e-0414272GO:0051231
GeneOntologyBiologicalProcesscell division

KIF4A KIF4B KLHL9 KIF2B YTHDF2 KLHL13

2.35e-04697276GO:0051301
GeneOntologyCellularComponentmultivesicular body lumen

PGA4 PGA5 PGA3

8.37e-087293GO:0097486
GeneOntologyCellularComponentlate endosome lumen

PGA4 PGA5 PGA3

3.93e-0711293GO:0031906
GeneOntologyCellularComponentCul3-RING ubiquitin ligase complex

KLHL9 LZTR1 KLHL13

2.12e-0539293GO:0031463
GeneOntologyCellularComponentendosome lumen

PGA4 PGA5 PGA3

2.85e-0543293GO:0031904
GeneOntologyCellularComponentmicrotubule associated complex

KIF21B KIF4A KIF4B KIF2B

6.93e-05161294GO:0005875
GeneOntologyCellularComponentmultivesicular body

PGA4 PGA5 PGA3

2.43e-0488293GO:0005771
GeneOntologyCellularComponentendosome

KIF21B PGA4 LZTR1 RIPK1 PGA5 PGA3 AOC3

8.76e-041167297GO:0005768
GeneOntologyCellularComponentkinesin complex

KIF21B KIF2B

2.10e-0349292GO:0005871
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

KLHL9 LZTR1 KLHL13

3.09e-03212293GO:0031461
GeneOntologyCellularComponentmidbody

KIF4A KIF4B KLHL9

3.52e-03222293GO:0030496
MousePhenoincreased dendritic spine number

KIF4A KIF4B

5.83e-063202MP:0021019
MousePhenobehavioral developmental delay

KIF4A KIF4B

5.42e-058202MP:0021165
MousePhenoabnormal hippocampus size

KIF4A KIF4B KCNA1

6.27e-0555203MP:0008281
MousePhenoabnormal dendritic spine number

KIF4A KIF4B

8.69e-0510202MP:0021017
MousePhenoabnormal dendritic spine morphology

KIF21B KIF4A KIF4B

5.58e-04115203MP:0009936
MousePhenoincreased susceptibility to pharmacologically induced seizures

KIF4A KIF4B KCNA1

5.87e-04117203MP:0002906
MousePhenoincreased susceptibility to induction of seizure by inducing agent

KIF4A KIF4B KCNA1

6.02e-04118203MP:0012349
MousePhenoimpaired long-term object recognition memory

KIF4A KIF4B

7.19e-0428202MP:0014367
MousePhenoimpaired learning

KIF21B KIF4A KIF4B

1.12e-03146203MP:0012315
MousePhenoabnormal seizure response to pharmacological agent

KIF4A KIF4B KCNA1

1.14e-03147203MP:0000950
MousePhenoimpaired conditioning behavior

KIF21B KIF4A KIF4B

1.59e-03165203MP:0012317
DomainAspartic_peptidase_N

PGA4 PGA5 PGA3

1.05e-077283IPR012848
DomainA1_Propeptide

PGA4 PGA5 PGA3

1.05e-077283PF07966
DomainAspartic_peptidase_A1

PGA4 PGA5 PGA3

3.60e-0710283IPR001461
DomainPEPTIDASE_A1

PGA4 PGA5 PGA3

3.60e-0710283IPR033121
DomainAsp

PGA4 PGA5 PGA3

3.60e-0710283PF00026
DomainPEPTIDASE_A1

PGA4 PGA5 PGA3

3.60e-0710283PS51767
DomainKinesin_motor_CS

KIF21B KIF4A KIF4B KIF2B

3.94e-0741284IPR019821
DomainKinesin-like_fam

KIF21B KIF4A KIF4B KIF2B

4.79e-0743284IPR027640
DomainKINESIN_MOTOR_1

KIF21B KIF4A KIF4B KIF2B

5.26e-0744284PS00411
Domain-

KIF21B KIF4A KIF4B KIF2B

5.26e-07442843.40.850.10
DomainKinesin_motor_dom

KIF21B KIF4A KIF4B KIF2B

5.26e-0744284IPR001752
DomainKinesin

KIF21B KIF4A KIF4B KIF2B

5.26e-0744284PF00225
DomainKISc

KIF21B KIF4A KIF4B KIF2B

5.26e-0744284SM00129
DomainKINESIN_MOTOR_2

KIF21B KIF4A KIF4B KIF2B

5.26e-0744284PS50067
Domain-

PGA4 PGA5 PGA3

6.58e-07122832.40.70.10
DomainASP_PROTEASE

PGA4 PGA5 PGA3

6.58e-0712283PS00141
DomainAspartic_peptidase_AS

PGA4 PGA5 PGA3

8.54e-0713283IPR001969
DomainPeptidase_aspartic_dom

PGA4 PGA5 PGA3

2.02e-0617283IPR021109
DomainKelch

KLHL9 LZTR1 KLHL13

8.81e-0558283SM00612
DomainGal_Oxase/kelch_b-propeller

KLHL9 LZTR1 KLHL13

9.27e-0559283IPR011043
DomainBTB

KLHL9 LZTR1 KCNA1 KLHL13

1.43e-04180284SM00225
DomainKelch_1

KLHL9 LZTR1 KLHL13

1.54e-0470283PF01344
DomainKelch_1

KLHL9 LZTR1 KLHL13

1.54e-0470283IPR006652
DomainBTB/POZ_dom

KLHL9 LZTR1 KCNA1 KLHL13

1.58e-04185284IPR000210
DomainSKP1/BTB/POZ

KLHL9 LZTR1 KCNA1 KLHL13

1.72e-04189284IPR011333
Domain-

KLHL9 KLHL13

7.43e-04272822.130.10.80
DomainBTB

KLHL9 LZTR1 KLHL13

9.72e-04131283PF00651
DomainGal_Oxidase_b-propeller

KLHL9 KLHL13

1.18e-0334282IPR015916
DomainBTB

KLHL9 LZTR1 KLHL13

1.73e-03160283PS50097
DomainBTB-kelch_protein

KLHL9 KLHL13

1.88e-0343282IPR017096
DomainBACK

KLHL9 KLHL13

3.64e-0360282SM00875
DomainBACK

KLHL9 KLHL13

3.76e-0361282PF07707
DomainBACK

KLHL9 KLHL13

3.76e-0361282IPR011705
DomainPrefoldin

KIF21B KIF4A

5.19e-0372282IPR009053
PathwayWP_GASTRIC_ACID_PRODUCTION

PGA4 PGA5 PGA3

6.21e-0711233M39726
PathwayREACTOME_KINESINS

KIF21B KIF4A KIF4B KIF2B

2.01e-0657234MM15714
PathwayREACTOME_KINESINS

KIF21B KIF4A KIF4B KIF2B

2.64e-0661234M977
PathwayREACTOME_SURFACTANT_METABOLISM

PGA4 PGA5 PGA3

1.50e-0530233M27566
PathwayREACTOME_COPI_DEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC

KIF21B KIF4A KIF4B KIF2B

1.76e-0598234MM15352
PathwayREACTOME_COPI_DEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC

KIF21B KIF4A KIF4B KIF2B

1.90e-05100234M27650
PathwayREACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION

KIF21B KIF4A KIF4B KIF2B

3.42e-05116234MM15715
PathwayREACTOME_GOLGI_TO_ER_RETROGRADE_TRANSPORT

KIF21B KIF4A KIF4B KIF2B

5.50e-05131234MM15497
PathwayREACTOME_GOLGI_TO_ER_RETROGRADE_TRANSPORT

KIF21B KIF4A KIF4B KIF2B

6.01e-05134234M27751
PathwayREACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION

KIF21B KIF4A KIF4B KIF2B

1.51e-04170234M941
PathwayREACTOME_INTRA_GOLGI_AND_RETROGRADE_GOLGI_TO_ER_TRAFFIC

KIF21B KIF4A KIF4B KIF2B

2.27e-04189234MM15356
PathwayREACTOME_INTRA_GOLGI_AND_RETROGRADE_GOLGI_TO_ER_TRAFFIC

KIF21B KIF4A KIF4B KIF2B

2.98e-04203234M27654
PathwayREACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION

KIF4A KIF4B KIF2B

8.53e-04116233MM14855
PathwayREACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION

KIF4A KIF4B KIF2B

1.08e-03126233M705
PathwayREACTOME_RECYCLING_PATHWAY_OF_L1

KIF4A KIF4B

1.64e-0337232MM15102
PathwayPID_AURORA_B_PATHWAY

KLHL9 KLHL13

1.82e-0339232M14
Pubmed

Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.

PGA4 PGA5 PGA3

5.21e-1032932032552
Pubmed

Close linkage of human chromosomal pepsinogen A genes.

PGA4 PGA5 PGA3

5.21e-1032933017318
Pubmed

Serum pepsinogen test for early detection of gastric cancer in a European country.

PGA4 PGA5 PGA3

5.21e-10329321989121
Pubmed

Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.

PGA4 PGA5 PGA3

5.21e-1032938053437
Pubmed

Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.

PGA4 PGA5 PGA3

5.21e-1032939855083
Pubmed

Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.

PGA4 PGA5 PGA3

5.21e-1032939797498
Pubmed

The glomerular sieving of pepsinogen A and C in man.

PGA4 PGA5 PGA3

5.21e-1032932478370
Pubmed

Analysis of the promoter of a human pepsinogen A gene.

PGA4 PGA5 PGA3

5.21e-1032931812762
Pubmed

O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.

PGA4 PGA5 PGA3

5.21e-1032937923573
Pubmed

Family and population studies on the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

5.21e-1032932566575
Pubmed

Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.

PGA4 PGA5 PGA3

5.21e-1032939061458
Pubmed

Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.

PGA4 PGA5 PGA3

5.21e-10329312588289
Pubmed

Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.

PGA4 PGA5 PGA3

5.21e-1032933815274
Pubmed

Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.

PGA4 PGA5 PGA3

5.21e-1032932229438
Pubmed

Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.

PGA4 PGA5 PGA3

5.21e-10329325314140
Pubmed

Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.

PGA4 PGA5 PGA3

5.21e-10329319890696
Pubmed

Pepsinogens: physiology, pharmacology pathophysiology and exercise.

PGA4 PGA5 PGA3

5.21e-10329310675278
Pubmed

Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.

PGA4 PGA5 PGA3

5.21e-10329323897256
Pubmed

An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.

PGA4 PGA5 PGA3

5.21e-10329311566730
Pubmed

The effect of acute and chronic protein loading on urinary pepsinogen A excretion.

PGA4 PGA5 PGA3

5.21e-1032931956484
Pubmed

The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.

PGA4 PGA5 PGA3

5.21e-1032937926498
Pubmed

Transcription regulation of human and porcine pepsinogen A.

PGA4 PGA5 PGA3

5.21e-1032938540382
Pubmed

Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.

PGA4 PGA5 PGA3

5.21e-1032933780036
Pubmed

Crystal structure of human pepsinogen A.

PGA4 PGA5 PGA3

5.21e-1032939561228
Pubmed

Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.

PGA4 PGA5 PGA3

5.21e-1032938244094
Pubmed

The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.

PGA4 PGA5 PGA3

5.21e-10329321455714
Pubmed

Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.

PGA4 PGA5 PGA3

5.21e-10329321407214
Pubmed

Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.

PGA4 PGA5 PGA3

5.21e-10329319800305
Pubmed

Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.

PGA4 PGA5 PGA3

5.21e-1032932901984
Pubmed

Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.

PGA4 PGA5 PGA3

5.21e-10329322992016
Pubmed

The role of serum pepsinogen in the detection of gastric cancer.

PGA4 PGA5 PGA3

5.21e-10329320981206
Pubmed

Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.

PGA4 PGA5 PGA3

5.21e-1032933839486
Pubmed

Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.

PGA4 PGA5 PGA3

5.21e-1032936774973
Pubmed

Gastric chief cell-specific transcription of the pepsinogen A gene.

PGA4 PGA5 PGA3

5.21e-1032938504820
Pubmed

Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.

PGA4 PGA5 PGA3

5.21e-10329321970995
Pubmed

Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.

PGA4 PGA5 PGA3

5.21e-10329324170207
Pubmed

Primary structure of human pepsinogen gene.

PGA4 PGA5 PGA3

5.21e-1032936300126
Pubmed

Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.

PGA4 PGA5 PGA3

5.21e-10329322304859
Pubmed

Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.

PGA4 PGA5 PGA3

5.21e-10329324004680
Pubmed

Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.

PGA4 PGA5 PGA3

5.21e-1032938038355
Pubmed

Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.

PGA4 PGA5 PGA3

5.21e-1032933467902
Pubmed

The pepsinogens of human gastric mucosa.

PGA4 PGA5 PGA3

5.21e-1032934586732
Pubmed

Serum pepsinogens in gastric cancer screening.

PGA4 PGA5 PGA3

5.21e-10329320428942
Pubmed

Relationships between the human pepsinogen DNA and protein polymorphisms.

PGA4 PGA5 PGA3

5.21e-1032933014868
Pubmed

Human pepsinogen A isozymogen patterns in serum and gastric mucosa.

PGA4 PGA5 PGA3

5.21e-1032932227273
Pubmed

Genomic structure and evolution of the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

5.21e-1032932892778
Pubmed

The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.

PGA4 PGA5 PGA3

5.21e-10329324383519
Pubmed

The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.

PGA4 PGA5 PGA3

5.21e-1032939525001
Pubmed

Gene structures of pepsinogens A and C.

PGA4 PGA5 PGA3

5.21e-1032931455184
Pubmed

Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.

PGA4 PGA5 PGA3

5.21e-1032937886402
Pubmed

Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.

PGA4 PGA5 PGA3

5.21e-1032932831884
Pubmed

Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.

PGA4 PGA5 PGA3

5.21e-10329323034090
Pubmed

A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.

PGA4 PGA5 PGA3

5.21e-10329324125879
Pubmed

Serum pepsinogen and gastric cancer screening.

PGA4 PGA5 PGA3

5.21e-10329317379991
Pubmed

Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.

PGA4 PGA5 PGA3

5.21e-1032938751234
Pubmed

Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.

PGA4 PGA5 PGA3

5.21e-1032933554488
Pubmed

The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.

PGA4 PGA5 PGA3

5.21e-1032932799289
Pubmed

CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.

PGA4 PGA5 PGA3

5.21e-10329319872561
Pubmed

Human pepsinogen A (PGA): an informative gene complex located at 11q13.

PGA4 PGA5 PGA3

5.21e-1032931968039
Pubmed

Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.

PGA4 PGA5 PGA3

5.21e-10329321547904
Pubmed

Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.

PGA4 PGA5 PGA3

5.21e-10329323521833
Pubmed

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.

PGA4 PGA5 PGA3

2.08e-09429323047493
Pubmed

Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.

PGA4 PGA5 PGA3

2.08e-0942938322031
Pubmed

Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.

PGA4 PGA5 PGA3

2.08e-09429317136346
Pubmed

Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

PGA4 PGA5 PGA3

2.08e-09429312698190
Pubmed

Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.

PGA4 PGA5 PGA3

2.08e-09429311915945
Pubmed

Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.

PGA4 PGA5 PGA3

5.21e-09529322066020
Pubmed

All kinesin superfamily protein, KIF, genes in mouse and human.

KIF21B KIF4A KIF4B KIF2B

2.53e-083729411416179
Pubmed

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.

DPP4 PGA4 PGA5 PGA3

3.86e-084129423676500
Pubmed

Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.

PGA4 PGA5 PGA3

4.22e-071829336057966
Pubmed

KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.

KIF4A KIF4B

6.71e-07229236482480
Pubmed

KIF4 regulates midzone length during cytokinesis.

KIF4A KIF4B

6.71e-07229221565503
Pubmed

Crystal structure of human pepsin and its complex with pepstatin.

PGA4 PGA5

6.71e-0722927663352
Pubmed

Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.

KIF4A KIF4B

6.71e-07229231486502
Pubmed

Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.

PGA4 PGA5

6.71e-0722922415509
Pubmed

Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.

KIF4A KIF4B

6.71e-07229210773663
Pubmed

A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.

KIF4A KIF4B

6.71e-0722927929562
Pubmed

Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.

PGA4 PGA5

6.71e-0722922714789
Pubmed

The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.

KIF4A KIF4B

6.71e-07229230081192
Pubmed

Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus.

KIF4A KIF4B

6.71e-07229231616463
Pubmed

Structural basis for the ATP-induced isomerization of kinesin.

KIF4A KIF4B

6.71e-07229223500491
Pubmed

Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.

KIF4A KIF4B

6.71e-07229231067151
Pubmed

Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages.

KIF4A KIF4B

6.71e-07229228350061
Pubmed

Activation of human pepsinogens.

PGA4 PGA5

6.71e-0722923197840
Pubmed

Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.

KIF4A KIF4B

6.71e-0722929658142
Pubmed

Cellular motor protein KIF-4 associates with retroviral Gag.

KIF4A KIF4B

6.71e-07229210559369
Pubmed

Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.

KIF4A KIF4B

6.71e-07229224658398
Pubmed

Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.

KIF4A KIF4B

2.01e-06329210978527
Pubmed

IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice.

A1CF IRX2

2.01e-06329237587150
Pubmed

KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.

KIF4A KIF4B

2.01e-06329216630823
Pubmed

Targeting Cul3-scaffold E3 ligase complex via KLHL substrate adaptors for cancer therapy.

KLHL9 KLHL13

2.01e-06329233872809
Pubmed

CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.

KIF4A KIF4B

2.01e-06329235579738
Pubmed

Tumor formation via loss of a molecular motor protein.

KIF4A KIF4B

2.01e-06329216890532
Pubmed

KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.

KIF4A KIF4B

2.01e-06329219158085
Pubmed

A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.

PGA4 PGA5

2.01e-0632922515193
Pubmed

Multiple roles of epithelial heparan sulfate in stomach morphogenesis.

PGA4 PGA5 PGA3

3.35e-063529329700203
Pubmed

An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.

PGA4 PGA5 PGA3

3.97e-063729321362171
Pubmed

Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.

KIF4A KIF4B

4.02e-06429218684836
Pubmed

Kif4 Is Essential for Mouse Oocyte Meiosis.

KIF4A KIF4B

4.02e-06429228125646
Pubmed

DPP-4 inhibition has beneficial effects on the heart after myocardial infarction.

DPP4 A1CF

6.70e-06529226739213
InteractionVIP interactions

DPP4 KLHL9 KLHL13

4.18e-0623283int:VIP
InteractionC1QTNF3 interactions

KLHL9 KLHL13

8.32e-0510282int:C1QTNF3
InteractionIGLV6-57 interactions

KLHL9 KLHL13

1.02e-0411282int:IGLV6-57
InteractionMZB1 interactions

KLHL9 KLHL13

1.22e-0412282int:MZB1
InteractionKIF4B interactions

KIF4A KIF4B

1.68e-0414282int:KIF4B
InteractionTMEM44 interactions

KLHL9 KLHL13

1.93e-0415282int:TMEM44
InteractionKIRREL2 interactions

KLHL9 KLHL13

1.93e-0415282int:KIRREL2
InteractionNEK1 interactions

ATRIP RIPK1 KIF2B

2.12e-0484283int:NEK1
Cytoband11q12.2

PGA4 PGA3

2.81e-043929211q12.2
CytobandEnsembl 112 genes in cytogenetic band chr11q12

PGA4 PGA5 PGA3

1.33e-03345293chr11q12
Cytoband1q32.1

KIF21B IGFN1

2.14e-031082921q32.1
CytobandEnsembl 112 genes in cytogenetic band chr1p35

DNAJC8 YTHDF2

3.40e-03137292chr1p35
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF21B KIF4A KIF4B KIF2B

1.72e-0746204622
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL9 LZTR1 KLHL13

4.14e-04134203861
GeneFamilyKelch like|BTB domain containing

KLHL9 KLHL13

9.75e-0442202617
DrugN-phenylphthalimide

DPP4 TMEM132D

7.00e-0510292CID000068215
DrugCyclobenzaprine hydrochloride [6202-23-9]; Up 200; 12.8uM; HL60; HT_HG-U133A

DPP4 SLC12A8 LZTR1 DNAJC8

9.87e-051922941332_UP
DrugSuprofen [40828-46-4]; Up 200; 15.4uM; PC3; HT_HG-U133A

DPP4 A1CF C8A AOC3

1.07e-041962944005_UP
Drugp-aminobenzamidine

NAT1 PGA5 AOC3

1.48e-0481293CID000001725
DrugTMOF

DPP4 TMEM132D

1.86e-0416292CID005488810
Drugdoyle

DPP4 KCNA1 RFX1

1.90e-0488293CID000002245
Druggliquidone

KCNA1 AOC3

3.24e-0421292CID000091610
DrugSMX-HA

NAT1 TMEM132D

3.56e-0422292CID000114821
Drugpyriproxyfen

RFX1 TMEM132D

3.90e-0423292CID000091753
DrugValboroPro

DPP4 IRX2

5.80e-0428292CID006918572
DrugFIAU

KCNA1 TMEM132D

5.80e-0428292CID000050313
Drugbutter yellow

NAT1 DPP4

6.67e-0430292CID000007340
DrugPCB 47

TMEM132D AOC3

7.12e-0431292CID000017097
Drugtemephos

KCNA1 RFX1

8.07e-0433292CID000005392
DrugAC1O43SR

NAT1 AOC3

8.07e-0433292CID006323539
Drugmuraglitazar

DPP4 IRX2

9.61e-0436292CID000206044
DrugAC1L1DUT

NAT1 AOC3

1.07e-0338292CID000002516
Diseaseepilepsy (implicated_via_orthology)

KIF4A KIF4B KCNA1 RIPK1

1.43e-05163274DOID:1826 (implicated_via_orthology)
Diseasephosphatidylcholine 36:3 measurement

KIF2B TMEM132D

8.40e-0515272EFO_0010381
Diseaselongevity

KIF21B KCNA1 ATRIP

2.17e-03284273EFO_0004300
Diseasesleep measurement

TMEM132D MPPED1

6.77e-03135272EFO_0004870

Protein segments in the cluster

PeptideGeneStartEntry
TIGFETTMLGGYVYS

NAT1

81

P18440
DYGTHYITSGSMGGI

C8A

336

P07357
TGGRGTMLQGEYTYS

A1CF

316

Q9NQ94
TTRYVDGGFGMGKYT

AOC3

381

Q16853
IFYGTGLGVYLSSTM

OR7A2P

251

Q8NGA2
TYGTGSMTGILGYDT

PGA5

136

P0DJD9
TTVGYGDMYPVTIGG

KCNA1

371

Q09470
YGSSMFVFGGYTGDI

LZTR1

126

Q8N653
YGTMTGCGSSSYTVT

GPR137C

381

Q8N3F9
YGQTGAGKTYTMGTG

KIF21B

86

O75037
GTVYGGLMYISGGIT

KLHL9

441

Q9P2J3
YGGYVTSMVLGSGSG

DPP4

631

P27487
GSGYTSMAIIYGVFS

MFSD11

46

O43934
HEGYGVMADGTTTYV

MPPED1

286

O15442
TTGMTGAISYHPYGS

IRX2

91

Q9BZI1
TYGTGSMTGILGYDT

PGA3

136

P0DJD8
YGGVMYISGGITHDT

KLHL13

486

Q9P2N7
GGGGSTEEAFMTFYS

DNAJC8

11

O75937
AYGQTGSGKTYSMGG

KIF4A

86

O95239
GSGKTYSMGGAYTAE

KIF4A

91

O95239
AYGQTGSGKTYSMGG

KIF4B

86

Q2VIQ3
GSGKTYSMGGAYTAE

KIF4B

91

Q2VIQ3
DMGPYSLGTGLYTSS

IGFN1

376

Q86VF2
GMSGLRTTGSYDGSF

ATRIP

356

Q8WXE1
IGSGGVYSMISSVLG

SLC12A8

101

A0AV02
AYGQTGSGKTYTMGG

KIF2B

301

Q8N4N8
TYGTGSMTGILGYDT

PGA4

136

P0DJD7
YYGSSSMGLMEGRGT

TMEM132D

841

Q14C87
GTYVIQGGYMLGSAS

RFX1

411

P22670
IGAYNYMEIGGTSSS

RIPK1

541

Q13546
STGGDTAMPYLTSYG

YTHDF2

76

Q9Y5A9