Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear pore outer ring	SEH1L SEC13	1.84e-04	10	43	2	GO:0031080
GeneOntologyCellularComponent	GATOR2 complex	SEH1L SEC13	2.69e-04	12	43	2	GO:0061700
GeneOntologyCellularComponent	Seh1-associated complex	SEH1L SEC13	4.87e-04	16	43	2	GO:0035859
Domain	WD_REPEATS_1	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 PALB2 SEC13 EML6	2.19e-06	278	41	7	PS00678
Domain	WD_REPEATS_2	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 PALB2 SEC13 EML6	2.24e-06	279	41	7	PS50082
Domain	WD_REPEATS_REGION	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 PALB2 SEC13 EML6	2.24e-06	279	41	7	PS50294
Domain	WD40_repeat_dom	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 PALB2 SEC13 EML6	3.39e-06	297	41	7	IPR017986
Domain	-	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 PALB2 SEC13 EML6	7.18e-06	333	41	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 PALB2 SEC13 EML6	7.47e-06	335	41	7	IPR015943
Domain	WD40	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 SEC13 EML6	2.01e-05	259	41	6	PF00400
Domain	WD40	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 SEC13 EML6	2.43e-05	268	41	6	SM00320
Domain	WD40_repeat	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 SEC13 EML6	2.65e-05	272	41	6	IPR001680
Domain	Glycoside_hydrolase_SF	IDUA GLB1L3 MGAM2	2.13e-04	53	41	3	IPR017853
Domain	-	IDUA GLB1L3	2.67e-03	35	41	2	3.20.20.80
Domain	Glyco_hydro_catalytic_dom	IDUA GLB1L3	3.14e-03	38	41	2	IPR013781
Domain	HEAT_REPEAT	PSME4 MROH2A	1.03e-02	70	41	2	PS50077
Pubmed	Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex.	SEH1L SEC13	4.48e-06	3	43	2	14517296
Pubmed	SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.	NIPSNAP2 AFG3L2	2.23e-05	6	43	2	26387735
Pubmed	High expression of Endogenous Retroviruses from intrauterine life to adulthood in two mouse models of Autism Spectrum Disorders.	TLR3 ITPR3	3.12e-05	7	43	2	29330412
Pubmed	Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex.	SEH1L SEC13	4.16e-05	8	43	2	27194810
Pubmed	Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex.	SEH1L SEC13	5.35e-05	9	43	2	17360435
Pubmed	The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.	SEH1L SEC13	6.68e-05	10	43	2	15146057
Pubmed	The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex.	SEH1L SEC13	6.68e-05	10	43	2	20676042
Pubmed	A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.	SEH1L SEC13	8.15e-05	11	43	2	23723238
Pubmed	Structure of the nutrient-sensing hub GATOR2.	SEH1L SEC13	1.15e-04	13	43	2	35831510
Pubmed	Ring domains are essential for GATOR2-dependent mTORC1 activation.	SEH1L SEC13	1.55e-04	15	43	2	36528027
Pubmed	Common body mass index-associated variants confer risk of extreme obesity.	EML6 ITPR3	1.55e-04	15	43	2	19553259
Pubmed	SZT2 dictates GATOR control of mTORC1 signalling.	SEH1L SEC13	1.77e-04	16	43	2	28199315
Pubmed	Network organization of the human autophagy system.	NIPSNAP2 SEH1L TGM3 STBD1 AFG3L2	1.99e-04	437	43	5	20562859
Pubmed	Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.	CLSTN2 EML6	2.52e-04	19	43	2	25367360
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	PLA2R1 LRP8 ITPR3	2.70e-04	101	43	3	23382219
Pubmed	KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.	SEH1L SEC13	2.80e-04	20	43	2	28199306
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	COL3A1 SEH1L PLA2R1 TGM3 HEG1 FADS3 TARS2 TLR3	3.55e-04	1451	43	8	30550785
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	IDUA MROH2A MGAM2 SEC13 ARID5B	3.56e-04	496	43	5	31343991
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	MON2 SEH1L STBD1 LRP8 ITPR3	3.83e-04	504	43	5	34432599
Pubmed	Integrated structural analysis of the human nuclear pore complex scaffold.	SEH1L SEC13	6.35e-04	30	43	2	24315095
Pubmed	The Structure Inventory of the Nuclear Pore Complex.	SEH1L SEC13	6.35e-04	30	43	2	27016207
Pubmed	The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.	SEH1L SEC13	7.69e-04	33	43	2	33452816
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	MON2 SEH1L MED6 PSME4 TARS2 AFG3L2 SEC13	8.17e-04	1257	43	7	37317656
Pubmed	A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.	DCAF12L1 DCAF12L2	9.67e-04	37	43	2	16949367
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SEH1L MED6 NFIL3 PALB2 AFG3L2 ITPR3 ARID5B	9.68e-04	1294	43	7	30804502
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	SEH1L SEC13	1.02e-03	38	43	2	12791264
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ARMT1 FER1L5 DCAF12L2 ITPR3 ARID5B	1.11e-03	638	43	5	31182584
Interaction	DCAF12L1 interactions	DCAF12L1 DCAF12L2	1.15e-05	3	40	2	int:DCAF12L1
Cytoband	Xq25	DCAF12L1 DCAF12L2	6.87e-04	41	43	2	Xq25
Cytoband	Ensembl 112 genes in cytogenetic band chrXq25	DCAF12L1 DCAF12L2	9.40e-04	48	43	2	chrXq25
Cytoband	2q11.2	C2orf92 FER1L5	2.10e-03	72	43	2	2q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2p16	PSME4 EML6	5.80e-03	121	43	2	chr2p16
GeneFamily	WD repeat domain containing	SEH1L DYNC2I1 DCAF12L1 DCAF12L2 SEC13 EML6	3.14e-06	262	29	6	362
GeneFamily	Nucleoporins	SEH1L SEC13	1.20e-03	32	29	2	1051
CoexpressionAtlas	JC_fibro_top-relative-expression-ranked_1000_k-means-cluster#1	COL3A1 PLA2R1 CLSTN2 HEG1 IDUA GEM ARID5B	2.27e-05	464	40	7	JC_fibro_1000_K1
Disease	Endogenous Hyperinsulinism	COL3A1 CD163	6.29e-04	26	42	2	C1257963
Disease	Exogenous Hyperinsulinism	COL3A1 CD163	6.29e-04	26	42	2	C1257964
Disease	Compensatory Hyperinsulinemia	COL3A1 CD163	6.29e-04	26	42	2	C1257965
Disease	Hyperinsulinism	COL3A1 CD163	7.30e-04	28	42	2	C0020459
Disease	Hyperglycemia, Postprandial	COL3A1 CD163	8.39e-04	30	42	2	C1855520
Disease	Hyperglycemia	COL3A1 CD163	8.39e-04	30	42	2	C0020456
Disease	Tinnitus	MON2 SORCS3 ARID5B	8.46e-04	130	42	3	HP_0000360
Disease	phosphatidylcholine 38:2 measurement	CLSTN2 FADS3	1.14e-03	35	42	2	EFO_0010384
Disease	cognitive inhibition measurement	WSCD2 TGM3	2.32e-03	50	42	2	EFO_0007969

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSNHKWMSKCGADWE	ARMT1	306	Q9H993
KKDDSHWWSRFQKGD	AFG3L2	121	Q9Y4W6
TANSEHFEGEKWKHW	ANKRD60	201	Q9BZ19
HFEGEKWKHWTSQRA	ANKRD60	206	Q9BZ19
EFHWKLDQICDKEWH	CLSTN2	441	Q9H4D0
EDIRNAAWHKHGWEE	NIPSNAP2	246	O75323
DMWENKGENEWLHDH	GEM	131	P55040
EVWLTWTDKNNEHHE	ITPR3	691	Q14573
SHSWEEGLKLVKWHF	PABIR3	106	Q6P4D5
TEWWTDQVAKFHDHL	MGAM2	456	Q2M2H8
WFDRWGDKHHVKDAK	GLB1L3	306	Q8NCI6
HGHKDWIFAVAWLSD	DCAF12L2	191	Q5VW00
HGHEEGSSVWWKLDQ	DYNC2I1	331	Q8WVS4
WSLKSEHWHQKELSG	NFIL3	391	Q16649
DAAWKHWPESNTEAH	HEG1	106	Q9ULI3
HHSRDTAEKQWAETW	MON2	1101	Q7Z3U7
DQHWSFVKWSGTDSH	PALB2	1156	Q86YC2
DGKTWWHNSEEKNFT	C2orf92	236	A0A1B0GVN3
KWRVENSWGEDHGHK	BLMH	391	Q13867
HVSKWNFETWNEPDH	IDUA	171	P35475
FWGWHNDVHIFDTKT	KLHDC1	166	Q8N7A1
HGHKDWIFAVAWLSD	DCAF12L1	191	Q5VU92
WTDSSAEKKHVWFGE	COL3A1	1316	P02461
GLDDFHSIVFWDWKK	EML6	791	Q6ZMW3
NWSGGWHHAKKDEAS	HDAC8	136	Q9BY41
ALWDCKHDGWGKHSN	CD163	126	Q86VB7
QHDLGHASIFKKSWW	FADS3	181	Q9Y5Q0
VKVWDKSESGDWHCT	SEH1L	36	Q96EE3
HGSHEVWIWSKAKFI	KIF28P	586	B7ZC32
WVHKHIYWTDSGNKT	LRP8	506	Q14114
PSKGYWWHFKDHEEQ	MED6	141	O75586
EHTEFTWDQKAWEDK	MROH2A	631	A6NES4
WREENGTWEKSHEHA	SEC13	86	P55735
LFSTKLWEQSGHWEH	TARS2	356	Q9BW92
GWHFKKDWVVELNHA	FER1L5	896	A0AVI2
RHLWVSFDEGHSWDK	SORCS3	631	Q9UPU3
KDPSSWKNWTHAQHF	PLA2R1	976	Q13018
DKGSDSVWNFHVWNE	TGM3	321	Q08188
KWVHSDFSKWRCGFH	ARID5B	111	Q14865
IHAYKDKDWVWEHFS	TLR3	761	O15455
FLETGHEDKVVHAWW	STBD1	341	O95210
KEWESSCFVEKTHWG	PSME4	1261	Q14997
HIGFAAHAHWKGKEW	WSCD2	436	Q2TBF2
KAPGWTEKNSHHSWE	USP54	976	Q70EL1